Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionstructural constituent of tooth enamel

AMELX AMELY

5.55e-056392GO:0030345
GeneOntologyMolecularFunctionhydroxyapatite binding

AMELX AMELY

1.03e-048392GO:0046848
GeneOntologyMolecularFunctionsodium ion binding

AMELX AMELY

3.33e-0414392GO:0031402
GeneOntologyMolecularFunctionextracellular matrix structural constituent conferring compression resistance

AMELX AMELY

9.16e-0423392GO:0030021
GeneOntologyMolecularFunctionalkali metal ion binding

AMELX AMELY

1.17e-0326392GO:0031420
GeneOntologyMolecularFunctiontRNA methyltransferase activity

TRMT1 LCMT2

2.00e-0334392GO:0008175
MousePhenoshort Tomes' process

AMELX AMELY

5.08e-062322MP:0030513
MousePhenoabnormal Tomes' process morphology

AMELX AMELY

1.52e-053322MP:0030512
MousePhenolarge mandible

AMELX AMELY

3.04e-054322MP:0030050
MousePhenoenamel pits

AMELX AMELY

5.06e-055322MP:0030460
MousePhenoshort upper incisors

AMELX AMELY

7.57e-056322MP:0030090
MousePhenosmall upper incisors

AMELX AMELY

1.06e-047322MP:0030081
MousePhenoshort lower incisors

AMELX AMELY

1.06e-047322MP:0030089
MousePhenoabnormal enamel rod pattern

AMELX AMELY

1.41e-048322MP:0002649
MousePhenoabnormal tooth wear

AMELX AMELY

2.26e-0410322MP:0030458
MousePhenosmall lower incisors

AMELX AMELY

2.76e-0411322MP:0030080
MousePhenobrittle teeth

AMELX AMELY

3.30e-0412322MP:0000126
MousePhenoreduced enamel thickness

AMELX AMELY

3.30e-0412322MP:0002577
MousePhenoincreased lung tissue damping

AMELX AMELY

3.90e-0413322MP:0011047
MousePhenoabnormal enamel mineralization

AMELX AMELY

3.90e-0413322MP:0030450
MousePhenoshort incisors

AMELX AMELY

4.54e-0414322MP:0004830
MousePhenoabnormal lung tissue damping

AMELX AMELY

5.97e-0416322MP:0011046
MousePhenoabnormal molar cusp morphology

AMELX AMELY

5.97e-0416322MP:0030457
MousePhenoabnormal incisor color

AMELX AMELY

5.97e-0416322MP:0010096
MousePhenoabnormal upper incisor morphology

AMELX AMELY

8.47e-0419322MP:0030137
MousePhenoabsent teeth

AMELX AMELY

9.40e-0420322MP:0030610
MousePhenodecreased cornea thickness

B3GNT7 CCDC180

1.04e-0321322MP:0005543
MousePhenosmall incisors

AMELX AMELY

1.14e-0322322MP:0030079
MousePhenoabnormal molar crown morphology

AMELX AMELY

1.14e-0322322MP:0003932
MousePhenoabnormal ameloblast morphology

AMELX AMELY

1.14e-0322322MP:0002650
DomainAmelogenin

AMELX AMELY

4.25e-062392IPR004116
DomainAmelogenin

AMELX AMELY

4.25e-062392SM00818
DomainAmelogenin

AMELX AMELY

4.25e-062392PF02948
DomainCyt_P450_E_grp-I

CYP1A1 CYP4F22

3.97e-0345392IPR002401
DomainCyt_P450_CS

CYP1A1 CYP4F22

5.47e-0353392IPR017972
DomainCYTOCHROME_P450

CYP1A1 CYP4F22

6.31e-0357392PS00086
Domain-

CYP1A1 CYP4F22

6.52e-03583921.10.630.10
Domainp450

CYP1A1 CYP4F22

6.52e-0358392PF00067
DomainCyt_P450

CYP1A1 CYP4F22

6.97e-0360392IPR001128
Pubmed

Amelogenin-deficient mice display an amelogenesis imperfecta phenotype.

AMELX AMELY

1.36e-06241211406633
Pubmed

Analysis of self-assembly and apatite binding properties of amelogenin proteins lacking the hydrophilic C-terminal.

AMELX AMELY

1.36e-06241211852235
Pubmed

The receptor activator of nuclear factor-kappa B ligand-mediated osteoclastogenic pathway is elevated in amelogenin-null mice.

AMELX AMELY

1.36e-06241212851394
Pubmed

Amelogenin, the major protein of tooth enamel: a new phylogenetic marker for ordinal mammal relationships.

AMELX AMELY

1.36e-06241218346915
Pubmed

Amelogenin genes and sexual dimorphism of teeth in humans and mice.

AMELX AMELY

1.36e-0624121463023
Pubmed

Amelogenin X impacts age-dependent increase of frequency and number in labial incisor grooves in C57BL/6.

AMELX AMELY

1.36e-06241229337060
Pubmed

Translocation of enamel proteins from inner enamel epithelia to odontoblasts during mouse tooth development.

AMELX AMELY

1.36e-0624128179220
Pubmed

Molecular cloning and DNA sequence of rat amelogenin and a comparative analysis of mammalian amelogenin protein sequence divergence.

AMELX AMELY

1.36e-0624128297387
Pubmed

Thermal denaturation of a recombinant mouse amelogenin: circular dichroism and differential scanning calorimetric studies.

AMELX AMELY

1.36e-06241216284958
Pubmed

Phosphorylation and ionic strength alter the LRAP-HAP interface in the N-terminus.

AMELX AMELY

1.36e-06241223477367
Pubmed

Protein interactions during assembly of the enamel organic extracellular matrix.

AMELX AMELY

1.36e-0624129041053
Pubmed

Highly acidic pH facilitates enamel protein self-assembly, apatite crystal growth and enamel protein interactions in the early enamel matrix.

AMELX AMELY

1.36e-06241236569763
Pubmed

Exon4 amelogenin transcripts in enamel biomineralization.

AMELX AMELY

1.36e-06241225792521
Pubmed

The leucine-rich amelogenin peptide alters the amelogenin null enamel phenotype.

AMELX AMELY

1.36e-06241218701811
Pubmed

Expression of amelogenin in odontoblasts.

AMELX AMELY

1.36e-06241212667550
Pubmed

Human and mouse amelogenin gene loci are on the sex chromosomes.

AMELX AMELY

1.36e-0624122737677
Pubmed

Spatial- and temporal-restricted pattern for amelogenin gene expression during mouse molar tooth organogenesis.

AMELX AMELY

1.36e-0624123253061
Pubmed

A solution NMR investigation into the early events of amelogenin nanosphere self-assembly initiated with sodium chloride or calcium chloride.

AMELX AMELY

1.36e-06241219086270
Pubmed

Molecular structure of the mouse amelogenin genomic DNA.

AMELX AMELY

1.36e-0624128988368
Pubmed

Hierarchical self-assembly of amelogenin and the regulation of biomineralization at the nanoscale.

AMELX AMELY

1.36e-06241221825148
Pubmed

Putative signaling action of amelogenin utilizes the Wnt/beta-catenin pathway.

AMELX AMELY

1.36e-06241219462488
Pubmed

Polypeptides translated from alternatively spliced transcripts of the amelogenin gene, devoid of the exon 6a, b, c region, have specific effects on tooth germ development in culture.

AMELX AMELY

1.36e-06241212489164
Pubmed

Isolation and characterization of a pseudoautosomal region-specific genetic marker in C57BL/6 mice using genomic representational difference analysis.

AMELX AMELY

1.36e-0624128618899
Pubmed

Amelogenin: a potential regulator of cementum-associated genes.

AMELX AMELY

1.36e-06241214653387
Pubmed

A synthetic, chemically modified ribozyme eliminates amelogenin, the major translation product in developing mouse enamel in vivo.

AMELX AMELY

1.36e-0624127489712
Pubmed

The leucine-rich amelogenin protein (LRAP) is primarily monomeric and unstructured in physiological solution.

AMELX AMELY

1.36e-06241225449314
Pubmed

High-yield recombinant bacterial expression of 13 C-, 15 N-labeled, serine-16 phosphorylated, murine amelogenin using a modified third generation genetic code expansion protocol.

AMELX AMELY

1.36e-06241236585836
Pubmed

Isolation and characterization of a mouse amelogenin expressed in Escherichia coli.

AMELX AMELY

1.36e-0624128062146
Pubmed

A mutation in the mouse Amelx tri-tyrosyl domain results in impaired secretion of amelogenin and phenocopies human X-linked amelogenesis imperfecta.

AMELX AMELY

1.36e-06241220067920
Pubmed

Transgenic mice that express normal and mutated amelogenins.

AMELX AMELY

1.36e-06241217384027
Pubmed

Novel LRAP-binding partner revealing the plasminogen activation system as a regulator of cementoblast differentiation and mineral nodule formation in vitro.

AMELX AMELY

1.36e-06241231621902
Pubmed

Reuptake of extracellular amelogenin by dental epithelial cells results in increased levels of amelogenin mRNA through enhanced mRNA stabilization.

AMELX AMELY

1.36e-06241216293627
Pubmed

Alternative splicing of the mouse amelogenin primary RNA transcript.

AMELX AMELY

1.36e-0624127820782
Pubmed

Controlled Osteogenic Differentiation of Mouse Mesenchymal Stem Cells by Tetracycline-Controlled Transcriptional Activation of Amelogenin.

AMELX AMELY

1.36e-06241226709694
Pubmed

Leucine rich amelogenin peptide alters ameloblast differentiation in vivo.

AMELX AMELY

1.36e-06241223747796
Pubmed

Evolution in tooth developmental biology: of morphology and molecules.

AMELX AMELY

1.36e-0624128769659
Pubmed

Amelogenin promotes odontoblast-like MDPC-23 cell differentiation via activation of ERK1/2 and p38 MAPK.

AMELX AMELY

1.36e-06241221547453
Pubmed

Amelogenin signal peptide mutation: correlation between mutations in the amelogenin gene (AMGX) and manifestations of X-linked amelogenesis imperfecta.

AMELX AMELY

1.36e-0624127782077
Pubmed

Alternative splicing of the mouse amelogenin primary RNA transcript contributes to amelogenin heterogeneity.

AMELX AMELY

1.36e-0624121445358
Pubmed

Altered amelogenin self-assembly based on mutations observed in human X-linked amelogenesis imperfecta (AIH1).

AMELX AMELY

1.36e-06241211877393
Pubmed

Comparison of body weight and gene expression in amelogenin null and wild-type mice.

AMELX AMELY

1.36e-06241216674684
Pubmed

Enamel ribbons, surface nodules, and octacalcium phosphate in C57BL/6 Amelx-/- mice and Amelx+/- lyonization.

AMELX AMELY

1.36e-06241227896287
Pubmed

Amelogenin-collagen interactions regulate calcium phosphate mineralization in vitro.

AMELX AMELY

1.36e-06241220404336
Pubmed

Maintenance of amelogenin gene expression by transformed epithelial cells of mouse enamel organ.

AMELX AMELY

1.36e-0624121444889
Pubmed

Partial rescue of the amelogenin null dental enamel phenotype.

AMELX AMELY

1.36e-06241218390542
Pubmed

Folding, assembly, and aggregation of recombinant murine amelogenins with T21I and P41T point mutations.

AMELX AMELY

1.36e-06241221540557
Pubmed

The energetic basis for hydroxyapatite mineralization by amelogenin variants provides insights into the origin of amelogenesis imperfecta.

AMELX AMELY

1.36e-06241231239344
Pubmed

Amelogenin in cranio-facial development: the tooth as a model to study the role of amelogenin during embryogenesis.

AMELX AMELY

1.36e-06241219097165
Pubmed

Identification of the functional activity of the [A-4] amelogenin gene splice product in newborn mouse ameloblasts.

AMELX AMELY

1.36e-06241218394981
Pubmed

A solution NMR investigation into the murine amelogenin splice-variant LRAP (Leucine-Rich Amelogenin Protein).

AMELX AMELY

1.36e-06241220304108
Pubmed

Endoplasmic reticulum stress in amelogenesis imperfecta and phenotypic rescue using 4-phenylbutyrate.

AMELX AMELY

1.36e-06241224362885
Pubmed

A solution NMR investigation into the impaired self-assembly properties of two murine amelogenins containing the point mutations T21→I or P41→T.

AMELX AMELY

1.36e-06241223896516
Pubmed

Two related low molecular mass polypeptide isoforms of amelogenin have distinct activities in mouse tooth germ differentiation in vitro.

AMELX AMELY

1.36e-06241215647828
Pubmed

DNA sequence for cloned cDNA for murine amelogenin reveal the amino acid sequence for enamel-specific protein.

AMELX AMELY

1.36e-0624124015654
Pubmed

Stage-Specific Role of Amelx Activation in Stepwise Ameloblast Induction from Mouse Induced Pluripotent Stem Cells.

AMELX AMELY

1.36e-06241234281250
Pubmed

The X-Y homologous gene amelogenin maps to the short arms of both the X and Y chromosomes and is highly conserved in primates.

AMELX AMELY

1.36e-0624121427830
Pubmed

Weaker dental enamel explains dental decay.

AMELX AMELY

1.36e-06241225885796
Pubmed

Transgene animal model for protein expression and accumulation into forming enamel.

AMELX AMELY

1.36e-06241211063035
Pubmed

Regulation of amelogenin gene expression.

AMELX AMELY

1.36e-06241210200911
Pubmed

Structural variation of the pseudoautosomal region between and within inbred mouse strains.

AMELX AMELY

1.36e-0624128552598
Pubmed

Truncated amelogenin and LRAP transgenes improve Amelx null mouse enamel.

AMELX AMELY

1.36e-06241226607574
Pubmed

A human X-Y homologous region encodes "amelogenin".

AMELX AMELY

1.36e-0624122004775
Pubmed

Loss of biological control of enamel mineralization in amelogenin-phosphorylation-deficient mice.

AMELX AMELY

1.36e-06241235219810
Pubmed

Of mice and men: anatomy of the amelogenin gene.

AMELX AMELY

1.36e-0624122689082
Pubmed

Altering biomineralization by protein design.

AMELX AMELY

1.36e-06241216707492
Pubmed

The amelogenin C-terminus is required for enamel development.

AMELX AMELY

1.36e-06241220042744
Pubmed

Amelogenin supramolecular assembly in nanospheres defined by a complex helix-coil-PPII helix 3D-structure.

AMELX AMELY

1.36e-06241221984897
Pubmed

Leucine rich amelogenin peptide prevents ovariectomy-induced bone loss in mice.

AMELX AMELY

1.36e-06241234780561
Pubmed

The murine amelogenin promoter: developmentally regulated expression in transgenic animals.

AMELX AMELY

1.36e-0624129084642
Pubmed

Comparison of upstream regions of X- and Y-chromosomal amelogenin genes.

AMELX AMELY

1.36e-0624129714776
Pubmed

Cryogenic transmission electron microscopy study of amelogenin self-assembly at different pH.

AMELX AMELY

1.36e-06241221597263
Pubmed

Characterization of copy number variation in genomic regions containing STR loci using array comparative genomic hybridization.

AMELX AMELY

1.36e-06241223948316
Pubmed

Antisense inhibition of AMEL translation demonstrates supramolecular controls for enamel HAP crystal growth during embryonic mouse molar development.

AMELX AMELY

1.36e-0624128392462
Pubmed

Amelogenin phosphorylation regulates tooth enamel formation by stabilizing a transient amorphous mineral precursor.

AMELX AMELY

1.36e-06241231919099
Pubmed

The small bovine amelogenin LRAP fails to rescue the amelogenin null phenotype.

AMELX AMELY

1.36e-06241212958690
Pubmed

[Types and frequencies of variants in Amelogenin gene in Chinese population].

AMELX AMELY

1.36e-06241218067069
Pubmed

Amelogenins as potential buffers during secretory-stage amelogenesis.

AMELX AMELY

1.36e-06241225535204
Pubmed

The circadian clock modulates enamel development.

AMELX AMELY

1.36e-06241222653892
Pubmed

An amelogenin mutation leads to disruption of the odontogenic apparatus and aberrant expression of Notch1.

AMELX AMELY

1.36e-06241220923441
Pubmed

Cloning, characterization, and heterologous expression of exon-4-containing amelogenin mRNAs.

AMELX AMELY

1.36e-0624129062557
Pubmed

Model system for evaluation of alternative splicing: exon skipping.

AMELX AMELY

1.36e-06241211879574
Pubmed

Patchy fur, a mouse coat mutation associated with X-Y nondisjunction, maps to the pseudoautosomal boundary region.

AMELX AMELY

1.36e-0624129878259
Pubmed

Mouse amelogenin exons 8 and 9: sequence analysis and protein distribution.

AMELX AMELY

1.36e-06241215972588
Pubmed

Early evolution of enamel matrix proteins is reflected by pleiotropy of physiological functions.

AMELX AMELY

4.06e-06341236702824
Pubmed

Origin, splicing, and expression of rodent amelogenin exon 8.

AMELX AMELY

4.06e-06341216998127
Pubmed

Early determination and permissive expression of amelogenin transcription during mouse mandibular first molar development.

AMELX AMELY

4.06e-0634128026631
Pubmed

Amelogenin binds to both heparan sulfate and bone morphogenetic protein 2 and pharmacologically suppresses the effect of noggin.

AMELX AMELY

4.06e-06341218515207
Pubmed

Expression and function of enamel-related gene products in calvarial development.

AMELX AMELY

4.06e-06341223625374
Pubmed

Alternative splicing of amelogenins.

AMELX AMELY

4.06e-0634127554909
Pubmed

Amyloid structure of high-order assembly of Leucine-rich amelogenin revealed by solid-state NMR.

AMELX AMELY

4.06e-06341229604451
Pubmed

Synergistic roles of amelogenin and ameloblastin.

AMELX AMELY

4.06e-06341219407150
Pubmed

The human enamel protein gene amelogenin is expressed from both the X and the Y chromosomes.

AMELX AMELY

4.06e-0634121734713
Pubmed

Tracking endogenous amelogenin and ameloblastin in vivo.

AMELX AMELY

4.06e-06341224933156
Pubmed

MMP20-generated amelogenin cleavage products prevent formation of fan-shaped enamel malformations.

AMELX AMELY

4.06e-06341234012043
Pubmed

GD3 synthase gene found expressed in dental epithelium and shown to regulate cell proliferation.

AMELX AMELY

4.06e-06341215748692
Pubmed

Binding of amelogenin to MMP-9 and their co-expression in developing mouse teeth.

AMELX AMELY

4.06e-06341222648084
Pubmed

Phenotype-genotype correlations in mouse models of amelogenesis imperfecta caused by Amelx and Enam mutations.

AMELX AMELY

4.06e-06341222759786
Pubmed

A developmental comparison of matrix metalloproteinase-20 and amelogenin null mouse enamel.

AMELX AMELY

4.06e-06341216674657
Pubmed

Amelogenin, a major structural protein in mineralizing enamel, is also expressed in soft tissues: brain and cells of the hematopoietic system.

AMELX AMELY

4.06e-06341216674683
Pubmed

Immunohistochemical similarities and differences between amelogenin and tuftelin gene products during tooth development.

AMELX AMELY

4.06e-0634129199671
Cytoband3q12.1

OR5AC2 OR5H6

1.62e-04214123q12.1
CytobandEnsembl 112 genes in cytogenetic band chr3q11

OR5AC2 OR5H6

1.08e-0354412chr3q11
CytobandEnsembl 112 genes in cytogenetic band chr15q24

CYP1A1 SEMA7A

5.37e-03122412chr15q24
Diseaseamelogenesis imperfecta type 1E (implicated_via_orthology)

AMELX AMELY

1.70e-062392DOID:0110058 (implicated_via_orthology)
Diseaseautosomal dominant hypocalcemia (biomarker_via_orthology)

AMELX AMELY

1.02e-054392DOID:0090109 (biomarker_via_orthology)
DiseaseOptic Atrophy

PIGQ TBCD

7.61e-0510392C0029124
Diseasestomach cancer (is_implicated_in)

CYP1A1 PIK3CA GPX3

1.20e-0472393DOID:10534 (is_implicated_in)
Diseaseesophageal cancer (is_implicated_in)

CYP1A1 GPX3

1.32e-0413392DOID:5041 (is_implicated_in)
DiseaseMalformations of Cortical Development

PIK3CA TBCD

1.53e-0414392C1955869
DiseaseCortical Dysplasia

PIK3CA TBCD

1.53e-0414392C0431380
DiseaseSitus ambiguus

SHROOM3 PKD1L1

1.77e-0415392C0266642
DiseaseMental Retardation, Psychosocial

TRMT1 SNX14 TBCD

8.26e-04139393C0025363
DiseaseProfound Mental Retardation

TRMT1 SNX14 TBCD

8.26e-04139393C0020796
DiseaseMental deficiency

TRMT1 SNX14 TBCD

8.26e-04139393C0917816
DiseaseDegenerative Diseases, Central Nervous System

TBCD GPX3

1.22e-0339392C0270715
Diseasedentate gyrus volume measurement

ITPRID1 PKD1L1

1.22e-0339392EFO_0010083
DiseaseDegenerative Diseases, Spinal Cord

TBCD GPX3

1.22e-0339392C0751733
DiseaseNeurodegenerative Disorders

TBCD GPX3

1.22e-0339392C0524851

Protein segments in the cluster

PeptideGeneStartEntry
PMGGWLHHQIIPVLS

AMELX

56

Q99217
PMGGWLHHQIIPVVS

AMELY

71

Q99218
FLVGPDGIPIMRWHH

GPX3

186

P22352
LRHSAWPPTLLQMVH

GIT1

51

Q9Y2X7
WIMIGDHHQLPPVIK

AQR

1091

O60306
NCHLMPHWPKELLQL

DNHD1

4156

Q96M86
HSLPNDWIMENPVLH

CCDC180

116

Q9P1Z9
LLHFWQGMPDHLLPL

RFX6

291

Q8HWS3
WPLIGHMLTLGKNPH

CYP1A1

46

P04798
KDSHLWQLLPMPHAE

ITPRID1

536

Q6ZRS4
GRHMWLAPILPGLVN

KATNIP

1471

O60303
LPGWPQDLLHMLLAR

LRRC17

76

Q8N6Y2
WVRHNGIVLLLPHGM

OGDHL

756

Q9ULD0
PGMEKAHHWIFIPLL

OR51B6

16

Q9H340
VHLHVLGGRQMHWPP

HINT1

111

P49773
WAEALGHLEHMLLKP

PARP4

271

Q9UKK3
MALNLWPVPHGLEDL

PIK3CA

441

P42336
LIVLIWKDPHLHIPM

OR5H6

61

Q8NGV6
GLIVLIWNDPHLHMP

OR5AC2

46

Q9NZP5
LLPPELLAMWGLVHS

B3GNT7

376

Q8NFL0
HLHRFLLSMWVLPPG

PKD1L1

2666

Q8TDX9
NMHHVLLVWMGPVLP

CYP4F22

91

Q6NT55
LLEWMEALHISGPQP

POM121L1P

391

Q3SYA9
QGQHLIPWMGDHKIL

SFSWAP

56

Q12872
HQLGGPMWAEPIHDL

TRMT1

391

Q9NXH9
LMSPFVEHILWHVGL

PIGQ

361

Q9BRB3
VQHFMWHPLPLVDRH

SH2D6

146

Q7Z4S9
EEMLPLFHHLTPRWG

SHROOM3

1286

Q8TF72
HWAIRQGHLPMVILL

ZDHHC13

121

Q8IUH4
NPIILPLWHVGMNDV

TAFAZZIN

176

Q16635
VFQVPDWLHHLLMGT

SNX14

801

Q9Y5W7
HLMTQHWGLDVPNLL

TRPM2

156

O94759
ATGILLHPWLRQDPM

TRIB3

306

Q96RU7
FLWLQEPMPALEGHI

XYLB

306

O75191
PLCQHMPRLHWLDLE

RXFP1

241

Q9HBX9
HWQLLPEDGIMAEHL

SEMA7A

626

O75326
WYHGVMGLLHPQPIE

SLC30A9

326

Q6PML9
MGLLHPQPIESLLWA

SLC30A9

331

Q6PML9
PHLLDPHLEWMMNLL

TBCD

71

Q9BTW9
HPVLVWHVTIPGSML

TMEM72

106

A0PK05
WPLMLHNHTSILLPE

LCMT2

636

O60294
PHWHLLLADILMAQG

TTC34

306

A8MYJ7