Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	phosphoric ester hydrolase activity	PDE1A PDE1C NT5DC4 MTMR8 PTPN22 DNAJC6 PTPRT INPP4B PPP1R3A PDP1 PLCB4 G6PC1	7.20e-05	386	161	12	GO:0042578
GeneOntologyMolecularFunction	hydrolase activity, acting on ester bonds	PDE1A PDE1C NT5DC4 MTMR8 ABHD3 TSN PTPN22 DNAJC6 PTPRT INPP4B PPP1R3A PDP1 LPL ENDOU PLCB4 DDHD2 MBD4 G6PC1	9.31e-05	807	161	18	GO:0016788
GeneOntologyMolecularFunction	calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity	PDE1A PDE1C	1.93e-04	3	161	2	GO:0048101
GeneOntologyMolecularFunction	calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity	PDE1A PDE1C	1.93e-04	3	161	2	GO:0004117
Domain	MacrogloblnA2_thiol-ester-bond	CD109 C4A C4B	3.05e-05	8	155	3	IPR019565
Domain	Thiol-ester_cl	CD109 C4A C4B	3.05e-05	8	155	3	PF10569
Domain	MacrogloblnA2_CS	CD109 C4A C4B	3.05e-05	8	155	3	IPR019742
Domain	A2M	CD109 C4A C4B	6.45e-05	10	155	3	PF00207
Domain	A2M_N_2	CD109 C4A C4B	6.45e-05	10	155	3	IPR011625
Domain	A2M_comp	CD109 C4A C4B	6.45e-05	10	155	3	IPR011626
Domain	A2M_recep	CD109 C4A C4B	6.45e-05	10	155	3	PF07677
Domain	A2M_comp	CD109 C4A C4B	6.45e-05	10	155	3	PF07678
Domain	A2M_N	CD109 C4A C4B	6.45e-05	10	155	3	PF01835
Domain	A2M_N	CD109 C4A C4B	6.45e-05	10	155	3	IPR002890
Domain	A-macroglobulin_rcpt-bd	CD109 C4A C4B	6.45e-05	10	155	3	IPR009048
Domain	ALPHA_2_MACROGLOBULIN	CD109 C4A C4B	6.45e-05	10	155	3	PS00477
Domain	A2M_N_2	CD109 C4A C4B	6.45e-05	10	155	3	PF07703
Domain	Macroglobln_a2	CD109 C4A C4B	6.45e-05	10	155	3	IPR001599
Domain	Cadherin_2	PCDHGB7 PCDHGB6 PCDH20 PCDH10 PCDH7	2.04e-04	65	155	5	PF08266
Domain	Cadherin_N	PCDHGB7 PCDHGB6 PCDH20 PCDH10 PCDH7	2.04e-04	65	155	5	IPR013164
Domain	PDEase_N	PDE1A PDE1C	2.04e-04	3	155	2	IPR013706
Domain	PDEase_I_N	PDE1A PDE1C	2.04e-04	3	155	2	PF08499
Domain	-	ITGB3 ITGB6	4.06e-04	4	155	2	1.20.5.630
Domain	Terpenoid_cyclase/PrenylTrfase	CD109 C4A C4B	4.17e-04	18	155	3	IPR008930
Domain	Anaphylatoxin_comp_syst	C4A C4B	6.73e-04	5	155	2	IPR018081
Domain	Anaphylatoxn_comp_syst_dom	C4A C4B	6.73e-04	5	155	2	IPR001840
Domain	NTR	TIMP4 C4A C4B	8.79e-04	23	155	3	PS50189
Domain	Netrin_domain	TIMP4 C4A C4B	8.79e-04	23	155	3	IPR001134
Domain	Integrin_b_cyt	ITGB3 ITGB6	1.00e-03	6	155	2	SM01241
Domain	Integrin_b_cyt	ITGB3 ITGB6	1.00e-03	6	155	2	PF08725
Domain	DUF3398	DOCK11 DOCK7	1.00e-03	6	155	2	PF11878
Domain	Integrin_bsu_cyt_dom	ITGB3 ITGB6	1.00e-03	6	155	2	IPR014836
Domain	DOCK_C/D_N	DOCK11 DOCK7	1.00e-03	6	155	2	IPR021816
Domain	Galactose-bd-like	PCSK5 F8 ANAPC10 NDUFAF1 CNTNAP4	1.12e-03	94	155	5	IPR008979
Domain	TIMP-like_OB-fold	TIMP4 C4A C4B	1.27e-03	26	155	3	IPR008993
Domain	ANATO	C4A C4B	1.40e-03	7	155	2	SM00104
Domain	ANAPHYLATOXIN_2	C4A C4B	1.40e-03	7	155	2	PS01178
Domain	ANAPHYLATOXIN_1	C4A C4B	1.40e-03	7	155	2	PS01177
Domain	Integrin_B_tail	ITGB3 ITGB6	1.40e-03	7	155	2	SM01242
Domain	ANATO	C4A C4B	1.40e-03	7	155	2	PF01821
Domain	Integrin_bsu_tail	ITGB3 ITGB6	1.40e-03	7	155	2	IPR012896
Domain	Anaphylatoxin/fibulin	C4A C4B	1.40e-03	7	155	2	IPR000020
Domain	Integrin_B_tail	ITGB3 ITGB6	1.40e-03	7	155	2	PF07965
Domain	TPR-contain_dom	TTC21A PRPF6 ZFC3H1 CABIN1 ANAPC5 NAA16	1.59e-03	150	155	6	IPR013026
Domain	INB	ITGB3 ITGB6	1.85e-03	8	155	2	SM00187
Domain	Integrin_bsu_VWA	ITGB3 ITGB6	1.85e-03	8	155	2	IPR002369
Domain	Integrin_beta	ITGB3 ITGB6	1.85e-03	8	155	2	PF00362
Domain	A2M_N_2	CD109 C4A	1.85e-03	8	155	2	SM01359
Domain	-	CD109 C4A	1.85e-03	8	155	2	2.60.40.690
Domain	A2M_recep	CD109 C4A	1.85e-03	8	155	2	SM01361
Domain	A2M	CD109 C4A	1.85e-03	8	155	2	SM01360
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	PCSK5 PKP4 NSUN2 ITGB3 ESF1 PACS1 PARP4 DST CLCN3 PRRC2C LPL DOCK7 KMT2A C4A C4B NMT1 ANAPC5 RIC1	1.58e-09	650	161	18	38777146
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	PDE1C MYO6 RPS2 TTC21A PKP4 DGKB DNAJC6 SLC4A1 PACS1 MLIP DST AMOT PRRC2C DOCK7 KMT2A SYT1 DLG4 ARPC5L C4A C4B DNAH6 ARMC8 DNAH11	2.08e-07	1431	161	23	37142655
Pubmed	Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.	MYO6 PKP4 ITGB3 INPP4B C2CD5 IFNGR1 SLC38A2 PACS1 DST DOCK7 SPRED1 ELMOD3	2.16e-07	377	161	12	38117590
Pubmed	Macrophage-derived complement component C4 can restore humoral immunity in C4-deficient mice.	IFNGR1 C4A C4B	3.88e-07	4	161	3	12421924
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	PKP4 ARFGEF1 GAL3ST4 ITGB6 PLIN2 IFNGR1 PACS1 DOCK7 ELMOD3 OCLN CAMSAP1 FGD6 PCDH7 VPS13B	4.70e-07	569	161	14	30639242
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PRUNE2 MYO6 COBLL1 ZFC3H1 CASZ1 C2CD5 CEP350 PARP4 CNTNAP4 DDHD2 FGD6 RIC1 KIF1C	5.67e-07	493	161	13	15368895
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	DOCK11 COBLL1 HJURP RFX7 CEP350 SLC38A2 BMX DST NKD2 AMOT PRRC2C DOCK7 KMT2A CAMSAP1 FGD6 PCDH7 KIF1C	5.82e-07	861	161	17	36931259
Pubmed	Genetic loci associated with circulating levels of very long-chain saturated fatty acids.	LVRN ATP8B1 ITGB3 DOCK7 PCDH7	1.48e-06	42	161	5	25378659
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	USP36 MYO6 RPS2 ARFGEF1 ESF1 CEP350 SLC38A2 DST AMOT DOCK7 OCLN CAMSAP1 SPEN PCDH10 PCDH7	3.65e-06	777	161	15	35844135
Pubmed	The DNA sequence and analysis of human chromosome 6.	MAK IMPG1 MYO6 MTRES1 CD109 NOX3 IFNGR1 MLIP DST C4A C4B RWDD2A TMEM181	7.21e-06	622	161	13	14574404
Pubmed	Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.	C4A C4B	2.13e-05	2	161	2	22737222
Pubmed	Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.	C4A C4B	2.13e-05	2	161	2	16565498
Pubmed	Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.	C4A C4B	2.13e-05	2	161	2	15998580
Pubmed	High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.	C4A C4B	2.13e-05	2	161	2	19062096
Pubmed	Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.	C4A C4B	2.13e-05	2	161	2	19933335
Pubmed	Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.	C4A C4B	2.13e-05	2	161	2	2459207
Pubmed	Antigen-induced B cell apoptosis is independent of complement C4.	C4A C4B	2.13e-05	2	161	2	17645767
Pubmed	Anti-DNA autoreactivity in C4-deficient mice.	C4A C4B	2.13e-05	2	161	2	12207352
Pubmed	Distinct Responses to Menin Inhibition and Synergy with DOT1L Inhibition in KMT2A-Rearranged Acute Lymphoblastic and Myeloid Leukemia.	KMT2A DOT1L	2.13e-05	2	161	2	38892207
Pubmed	Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.	C4A C4B	2.13e-05	2	161	2	27758680
Pubmed	Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.	C4A C4B	2.13e-05	2	161	2	22387014
Pubmed	Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.	C4A C4B	2.13e-05	2	161	2	23749435
Pubmed	Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.	C4A C4B	2.13e-05	2	161	2	23918728
Pubmed	Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.	C4A C4B	2.13e-05	2	161	2	3037333
Pubmed	Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.	C4A C4B	2.13e-05	2	161	2	11726230
Pubmed	Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.	C4A C4B	2.13e-05	2	161	2	4216347
Pubmed	Sequence determination of the thiolester site of the fourth component of human complement.	C4A C4B	2.13e-05	2	161	2	6950384
Pubmed	Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.	C4A C4B	2.13e-05	2	161	2	8660986
Pubmed	Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.	C4A C4B	2.13e-05	2	161	2	8428773
Pubmed	Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.	C4A C4B	2.13e-05	2	161	2	24638111
Pubmed	Transcriptional repression of C4 complement by hepatitis C virus proteins.	C4A C4B	2.13e-05	2	161	2	21345967
Pubmed	MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.	KMT2A DOT1L	2.13e-05	2	161	2	21741597
Pubmed	Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.	C4A C4B	2.13e-05	2	161	2	2572548
Pubmed	The complement component C4 of mammals.	C4A C4B	2.13e-05	2	161	2	2302180
Pubmed	Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.	C4A C4B	2.13e-05	2	161	2	22151770
Pubmed	C4d-positive chronic rejection: a frequent entity with a poor outcome.	C4A C4B	2.13e-05	2	161	2	18091514
Pubmed	Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.	C4A C4B	2.13e-05	2	161	2	29080553
Pubmed	Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.	C4A C4B	2.13e-05	2	161	2	6589636
Pubmed	DOT1L inhibition sensitizes MLL-rearranged AML to chemotherapy.	KMT2A DOT1L	2.13e-05	2	161	2	24858818
Pubmed	C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.	C4A C4B	2.13e-05	2	161	2	25339671
Pubmed	A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.	C4A C4B	2.13e-05	2	161	2	17728371
Pubmed	Structure and organization of the C4 genes.	C4A C4B	2.13e-05	2	161	2	6149580
Pubmed	Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.	C4A C4B	2.13e-05	2	161	2	6149581
Pubmed	The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.	C4A C4B	2.13e-05	2	161	2	12115608
Pubmed	Biochemistry and biology of anaphylatoxins.	C4A C4B	2.13e-05	2	161	2	3542363
Pubmed	C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.	C4A C4B	2.13e-05	2	161	2	2387317
Pubmed	Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.	C4A C4B	2.13e-05	2	161	2	16908004
Pubmed	Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.	C4A C4B	2.13e-05	2	161	2	7365238
Pubmed	Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.	C4A C4B	2.13e-05	2	161	2	7391573
Pubmed	Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.	C4A C4B	2.13e-05	2	161	2	17971360
Pubmed	Clinical features of patients with homozygous complement C4A or C4B deficiency.	C4A C4B	2.13e-05	2	161	2	29928053
Pubmed	Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.	C4A C4B	2.13e-05	2	161	2	17971229
Pubmed	Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.	C4A C4B	2.13e-05	2	161	2	6881182
Pubmed	Identification of IFN-gamma receptor binding sites for JAK2 and enhancement of binding by IFN-gamma and its C-terminal peptide IFN-gamma(95-133).	IFNGR1 JAK2	2.13e-05	2	161	2	7499845
Pubmed	The role of DOT1L in the maintenance of leukemia gene expression.	KMT2A DOT1L	2.13e-05	2	161	2	27151433
Pubmed	Partial C4 deficiency in juvenile idiopathic arthritis patients.	C4A C4B	2.13e-05	2	161	2	17921792
Pubmed	Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.	C4A C4B	2.13e-05	2	161	2	21880985
Pubmed	Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.	C4A C4B	2.13e-05	2	161	2	6978711
Pubmed	Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.	C4A C4B	2.13e-05	2	161	2	35898513
Pubmed	Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.	C4A C4B	2.13e-05	2	161	2	28873507
Pubmed	Stage and cell-specific expression of calmodulin-dependent phosphodiesterases in mouse testis.	PDE1A PDE1C	2.13e-05	2	161	2	11369604
Pubmed	Interaction of myosin VI and its binding partner DOCK7 plays an important role in NGF-stimulated protrusion formation in PC12 cells.	MYO6 DOCK7	2.13e-05	2	161	2	27018747
Pubmed	Studies on the murine Ss protein: demonstration that the Ss protein is functionally the fourth component of complement.	C4A C4B	2.13e-05	2	161	2	276882
Pubmed	Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.	C4A C4B	2.13e-05	2	161	2	6832377
Pubmed	Recombination of two homologous MHC class III genes of the mouse (C4 and Slp) that accounts for the loss of testosterone dependence of sex-limited protein expression.	C4A C4B	2.13e-05	2	161	2	3794341
Pubmed	Fine-tuned characterization of RCCX copy number variants and their relationship with extended MHC haplotypes.	C4A C4B	2.13e-05	2	161	2	22785613
Pubmed	Association between complement 4 copy number variation and systemic lupus erythematosus: a meta-analysis.	C4A C4B	2.13e-05	2	161	2	32691186
Pubmed	Hepatotoxicity from anabolic androgenic steroids marketed as dietary supplements: contribution from ATP8B1/ABCB11 mutations?	ATP8B1 ABCB11	2.13e-05	2	161	2	23750872
Pubmed	The androgen-dependent C4-Slp gene is driven by a constitutively competent promoter.	C4A C4B	2.13e-05	2	161	2	8390682
Pubmed	Structure and expression of murine fourth complement component (C4) and sex-limited protein (Slp).	C4A C4B	2.13e-05	2	161	2	3902619
Pubmed	Structural polymorphism of murine C4 and its linkage to H-2.	C4A C4B	2.13e-05	2	161	2	7373044
Pubmed	The chemical structure of the C4d fragment of the human complement component C4.	C4A C4B	2.13e-05	2	161	2	3696167
Pubmed	Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.	C4A C4B	2.13e-05	2	161	2	1357031
Pubmed	Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.	C4A C4B	2.13e-05	2	161	2	16098595
Pubmed	Differences in presentation and progression between severe FIC1 and BSEP deficiencies.	ATP8B1 ABCB11	2.13e-05	2	161	2	20447715
Pubmed	Receptor-binding domain of SARS-CoV-2 is a functional αv-integrin agonist.	ITGB3 ITGB6	2.13e-05	2	161	2	36669646
Pubmed	Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.	C4A C4B	2.13e-05	2	161	2	15787745
Pubmed	The Features of GGT in Patients with ATP8B1 or ABCB11 Deficiency Improve the Diagnostic Efficiency.	ATP8B1 ABCB11	2.13e-05	2	161	2	27050426
Pubmed	Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.	C4A C4B	2.13e-05	2	161	2	30026462
Pubmed	A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.	C4A C4B	2.13e-05	2	161	2	6559257
Pubmed	Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.	C4A C4B	2.13e-05	2	161	2	34299197
Pubmed	Assessment of complement C4 gene copy number using the paralog ratio test.	C4A C4B	2.13e-05	2	161	2	20506482
Pubmed	Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.	C4A C4B	2.13e-05	2	161	2	12480675
Pubmed	Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.	C4A C4B	2.13e-05	2	161	2	26800705
Pubmed	Murine complement C4 is not required for experimental autoimmune encephalomyelitis.	C4A C4B	2.13e-05	2	161	2	15390104
Pubmed	Integrin β3 mediates cerebrovascular remodelling through Src/ClC-3 volume-regulated Cl(-) channel signalling pathway.	ITGB3 CLCN3	2.13e-05	2	161	2	24611720
Pubmed	Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.	C4A C4B	2.13e-05	2	161	2	1699796
Pubmed	Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.	C4A C4B	2.13e-05	2	161	2	2997024
Pubmed	Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.	C4A C4B	2.13e-05	2	161	2	3624865
Pubmed	Recurrent PTPRT/JAK2 mutations in lung adenocarcinoma among African Americans.	PTPRT JAK2	2.13e-05	2	161	2	31844068
Pubmed	Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.	C4A C4B	2.13e-05	2	161	2	21857912
Pubmed	Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.	C4A C4B	2.13e-05	2	161	2	6208559
Pubmed	The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.	C4A C4B	2.13e-05	2	161	2	4514997
Pubmed	The inheritance of susceptibility to the Gross leukemia virus in mice.	C4A C4B	2.13e-05	2	161	2	5919331
Pubmed	An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene.	C4A C4B	2.13e-05	2	161	2	3167981
Pubmed	The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates.	C4A C4B	2.13e-05	2	161	2	7545960
Pubmed	Insights on the relationship between complement component C4 serum concentrations and C4 gene copy numbers in a Western Australian systemic lupus erythematosus cohort.	C4A C4B	2.13e-05	2	161	2	30041577
Pubmed	Complete cDNA sequence of the fourth component of murine complement.	C4A C4B	2.13e-05	2	161	2	3862104
Pubmed	The BS variant of C4 protects against age-related loss of white matter microstructural integrity.	C4A C4B	2.13e-05	2	161	2	34358307
Pubmed	Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d.	C4A C4B	2.13e-05	2	161	2	18360261
Cytoband	Ensembl 112 genes in cytogenetic band chr2q24	KCNH7 COBLL1 PKP4 ITGB6 CCDC148 LY75	6.17e-06	127	161	6	chr2q24
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	CD109 C4A C4B	1.79e-05	9	110	3	1234
GeneFamily	Non-clustered protocadherins	PCDH20 PCDH10 PCDH7	4.63e-05	12	110	3	21
GeneFamily	CD molecules\|Integrin beta subunits	ITGB3 ITGB6	1.28e-03	9	110	2	1159
GeneFamily	Glycosyltransferase family 6\|Blood group antigens	SLC4A1 C4A C4B	1.46e-03	37	110	3	454
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 DOCK11 SLC35F5 FANCC SLC6A12 PARP4 DNAH6 SDC2 HYDIN DNAH11	1.89e-09	189	161	10	904b8337e2cabac2f0bf5dad5598fc429581ed81
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 DOCK11 ASIC5 SLC35F5 FANCC PARP4 SDC2 HYDIN DNAH11	2.24e-08	182	161	9	5e1b316599436740f1b30875f0ebd33c3edfb2b6
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 DOCK11 CLDN4 ITGB6 SLC35F5 SLC6A12 PARP4 SDC2 HYDIN	2.35e-08	183	161	9	92fbd83a9d13ee91065cbd479fb298f1fd564568
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 DOCK11 ITGB6 PTPRT SLC35F5 PARP4 SDC2 HYDIN DNAH11	2.96e-08	188	161	9	63a4b25a0a6e05f80f1a6dd91b817f3cf49e6b68
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 DOCK11 COBLL1 SLC35F5 PARP4 AMOT SDC2 HYDIN DNAH11	3.71e-08	193	161	9	ffa1932da2979d7b63dbac32eb5788346a3f5b2a
ToppCell	COVID-19-Heart-CM_2\|Heart / Disease (COVID-19 only), tissue and cell type	PDE1C TMEM71 CASZ1 INPP4B MLIP DST LPL PCDH7 FYB2	4.06e-08	195	161	9	75fc81bddb246dca3b437fb60827b1d4fe416405
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 DOCK11 ASIC5 PTPRT PARP4 SDC2 HYDIN DNAH11	2.64e-07	176	161	8	327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PDE1A COBLL1 IGDCC3 ASIC5 PTPRT ADGRL4 CNTNAP4 PCDH10	3.26e-07	181	161	8	6e8c5460021d3999daec58e3d6661a6fa998fd16
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 DMGDH DOCK11 COBLL1 CLDN4 CCDC148 SLC6A12 PLCB4	3.26e-07	181	161	8	9d782ba5cf5a172cb4f447763fc50e5b13ef7dd9
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAK TTC21A CCDC148 NKD2 DNAH6 BBS12 HYDIN DNAH11	3.70e-07	184	161	8	264e14aa1859cfc0ed5fb40e97ea189aed9ef4a5
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAK TTC21A CCDC148 NKD2 DNAH6 BBS12 HYDIN DNAH11	3.70e-07	184	161	8	d7eccbd21c480d907fdc8eff2bf5ae22ae452221
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Epithelial-neuroepithelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAK TTC21A CCDC148 NKD2 DNAH6 BBS12 HYDIN DNAH11	3.70e-07	184	161	8	22010cfe0428ebfa40952cc1a1a12ad3d25b35c9
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 DOCK11 SLC35F5 FANCC DNAH6 SDC2 HYDIN DNAH11	4.02e-07	186	161	8	5c4ffe4e4d5536ae9f8794277fe032c693e7dd56
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH7 COBLL1 DGKB ITGB6 CASZ1 DST DOT1L OCLN	4.18e-07	187	161	8	f124d2c699b717b7c02a1a70493f515b83dc2f4c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDE1C MYO6 COBLL1 ABHD3 CASZ1 SLC4A1 DST FYB2	4.36e-07	188	161	8	e751cff2ac8fbc1487766c1871fcc5d1005286b0
ToppCell	LPS_only-Endothelial-Endothelial-Artery\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PCSK5 CD109 ADGRL4 BMX LPL CNTNAP4 PLCB4 PCDH10	4.53e-07	189	161	8	b028466fcd36fdeceec752e55a24286a1cd62ae4
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK11 COBLL1 ITGB6 SLC35F5 SLC6A12 PARP4 SDC2 HYDIN	4.91e-07	191	161	8	d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE1A CYSLTR2 MYO6 CLDN4 ATP8B1 INPP4B PCDH7 FYB2	5.74e-07	195	161	8	3d6d3de8ada6dce3dc789c15b50cc066e7100496
ToppCell	COVID-19-Heart-CM_1\|Heart / Disease (COVID-19 only), tissue and cell type	PDE1C TMEM71 CASZ1 INPP4B MLIP LPL PCDH7 FYB2	5.74e-07	195	161	8	f1ef50331eda8f1239dba6ea970df4eaccf032f1
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP47 TTC21A PTPRT KCNB1 DNAH6 HYDIN FYB2 DNAH11	6.20e-07	197	161	8	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PCSK5 CD109 GLYATL2 ATP8B1 ADGRL4 BMX DST BST2	6.70e-07	199	161	8	9b02acae6325b0ac9642438a4431285ff396e5fe
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Artery\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PCSK5 CD109 ADGRL4 BMX DST LPL PLCB4 PCDH10	6.95e-07	200	161	8	ac9ead34afa14067171833f5c277eaf06db7b02e
ToppCell	LPS_only-Endothelial-Endothelial-Artery\|LPS_only / Treatment groups by lineage, cell group, cell type	PCSK5 CD109 ADGRL4 BMX DST LPL PLCB4 PCDH10	6.95e-07	200	161	8	b17eb1587ca86c3d40515128a00a8d8fd787fccf
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Artery\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	PCSK5 CD109 ADGRL4 BMX DST CNTNAP4 PLCB4 PCDH10	6.95e-07	200	161	8	b1ff8d61b567f85006d6d20093f9c803b6d34674
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Artery\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	PCSK5 CD109 ADGRL4 BMX DST LPL PLCB4 PCDH10	6.95e-07	200	161	8	77ae679c35d3b9e2b620f34129f3a8d47e922c65
ToppCell	facs-Liver-Hepatocytes\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DMGDH ABHD3 SLC6A12 ABCB11 C4B G6PC1 SDC2	1.64e-06	156	161	7	e2cda3ad4e5f44a80133864c5a38b766afb952ce
ToppCell	PCW_07-8.5-Epithelial-Epithelial_ciliated-epi_ciliated_(14)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CFAP47 KCNH7 CLDN4 PCDH20 OCLN DNAH6 HYDIN	2.38e-06	165	161	7	0c714e852f912b5749de4cb0895406673979b2e6
ToppCell	PCW_07-8.5-Epithelial-Epithelial_ciliated\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CFAP47 KCNH7 CLDN4 PCDH20 OCLN DNAH6 HYDIN	2.38e-06	165	161	7	82530f96aaefe28a13bad0474bbad043f127a86c
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP47 MAK TTC21A DNAH6 HYDIN FYB2 DNAH11	2.79e-06	169	161	7	fba841664939c771881ba97f14ef1df6635c04ff
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MAK TTC21A PTPRT CCDC148 DNAH6 HYDIN DNAH11	2.79e-06	169	161	7	14aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PRUNE2 PDE1A PDE1C KCNH7 ASIC5 PTPRT DNAH6	3.52e-06	175	161	7	06af6629766e2054e6995e8cdb3907658fec49d3
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L5-6_RORB_LINC00320\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PCSK5 COBLL1 IGDCC3 ASIC5 ADGRL4 CNTNAP4 PCDH10	3.79e-06	177	161	7	01df8ab3285fa66b4805c555cfbfc4b3b16db919
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK11 ASIC5 PTPRT PARP4 SDC2 HYDIN DNAH11	3.79e-06	177	161	7	da8802a6351d3e510822f82e2fde8a4314a2216e
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK11 PTPRT FANCC PARP4 SDC2 HYDIN DNAH11	3.94e-06	178	161	7	c20f050344a2e120e685e2a7fe36c6dfc1dc37b6
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PRUNE2 PDE1A PDE1C ASIC5 PTPRT DNAH6 PCDH7	4.08e-06	179	161	7	b35a7f8115c997c390201da01d7cb10b10769aec
ToppCell	LV\|World / Chamber and Cluster_Paper	PDE1C TMEM71 INPP4B MLIP PLCB4 PCDH7 FYB2	4.24e-06	180	161	7	5ac6f485a58bb29462fec02dfbe8eb70864eafe3
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_HNRNPA1P46\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PDE1A PDE1C KCNH7 PTPRT PARP4 DNAH6 FGD6	4.24e-06	180	161	7	8923a42a6db9c6e9f3ce2ca9530e620dfea700ba
ToppCell	facs-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PRUNE2 PCSK5 IGDCC3 F8 BMX DST MBD4	4.24e-06	180	161	7	67c5068b660cd5e727a665cefe3bd5f8ae887221
ToppCell	facs-GAT-Fat-3m-Epithelial\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFAP47 MAK DNAJC6 CCDC148 OCLN HYDIN DNAH11	4.39e-06	181	161	7	11cb84528f7ca084f0a92eda4f2e18e63a428fe9
ToppCell	facs-GAT-Fat-3m-Epithelial-epithelial_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFAP47 MAK DNAJC6 CCDC148 OCLN HYDIN DNAH11	4.39e-06	181	161	7	e97cbaafb93fdbee8e3cf4a06e6bcf121d941403
ToppCell	COVID-19-Heart-CM_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PDE1C TMEM71 INPP4B PPP1R3A MLIP LPL PCDH7	4.39e-06	181	161	7	719eb532453ab7cd7893726885bc75d74a10b21e
ToppCell	facs-GAT-Fat-3m-Epithelial-nan\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFAP47 MAK DNAJC6 CCDC148 OCLN HYDIN DNAH11	4.39e-06	181	161	7	5ffeca29e4d31a20c110d27af128ed024a79ad56
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c4-CD14-CD16\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	CYSLTR2 PCDHGB6 NAIP SNUPN JAK2 LPL	4.53e-06	118	161	6	7e6cb77fa9154f2da985c455bb6a24d6029cc8d6
ToppCell	Control-Epithelial_cells-Airway_ciliated\|Control / group, cell type (main and fine annotations)	CFAP47 PTPRT CCDC148 DNAH6 HYDIN FYB2 DNAH11	4.56e-06	182	161	7	fb725d10d9ed25dfc6d5bb69cfef78513f7d3e8f
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 DMGDH DOCK11 COBLL1 CLDN4 SLC6A12 PLCB4	4.56e-06	182	161	7	eb138aa1dca9373f1586600f258df06dcf56d81f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 DOCK11 SLC35F5 SLC6A12 PARP4 SDC2 HYDIN	4.72e-06	183	161	7	738e94b50c4c08c727d4eed0708dda08aa6891b4
ToppCell	Pericytes-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	PRUNE2 PDE1A CCDC168 INPP4B KCNB1 PLCB4 PCDH7	4.72e-06	183	161	7	d04deef7cd4e1738227a6593b84874ce0168c773
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|LV / Chamber and Cluster_Paper	TMEM71 INPP4B MLIP DST LPL PCDH7 FYB2	4.90e-06	184	161	7	ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCell	TCGA-Uvea-Primary_Tumor-Uveal_Melanoma-Epithelioid_Cell-4\|TCGA-Uvea / Sample_Type by Project: Shred V9	MAN2A1 DOCK11 ABHD3 ARFGEF1 PDP1 SDC2 VPS13B	4.90e-06	184	161	7	9c56753e5e668be888662e4713cf4ce44e6c58fb
ToppCell	COVID-19-Heart-CM_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PDE1C TMEM71 PPP1R3A MLIP LPL PCDH7 FYB2	4.90e-06	184	161	7	e737f0f14c49b07bbb04a165083ac32210bc5690
ToppCell	COVID-19-Heart-CM_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PDE1C TMEM71 INPP4B PPP1R3A MLIP LPL PCDH7	5.07e-06	185	161	7	549eeb521c3985bff396ea0f202db21822efa51f
ToppCell	COVID-19-Epithelial_cells-Airway_ciliated\|COVID-19 / group, cell type (main and fine annotations)	CFAP47 PTPRT CCDC148 DNAH6 HYDIN FYB2 DNAH11	5.07e-06	185	161	7	18a40f0a338aa398d81384b5159fb80ce8a2020c
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PRUNE2 PDE1A PDE1C ASIC5 PTPRT DNAH6 PCDH7	5.07e-06	185	161	7	a1b2525da018abe458908cab7268bd403ee98d92
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDE1C MYO6 ABHD3 CASZ1 SLC4A1 DST FYB2	5.26e-06	186	161	7	a6ef5d5944af5689b5f27bef89cd05645eedbe50
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK11 ATP5MK LPL SELENOI TENT5D SDC2 DNAH11	5.26e-06	186	161	7	4bb54043f944a979db91bde9a86dd66f498c7658
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 DMGDH DOCK11 COBLL1 CLDN4 SLC6A12 PLCB4	5.44e-06	187	161	7	c41a2c81dd2ceef303f39f699032aa7d6ea67cf0
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH7 MYO6 COBLL1 ITGB6 CCDC148 DST OCLN	5.44e-06	187	161	7	77886f99c229610abd28c4c370d2c7d1536c9782
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE1C COBLL1 ATP8B1 SLC4A1 DOCK7 PCDH7 FYB2	5.44e-06	187	161	7	2d17408b3b5f09d135084fd7ccce98e6b5ca632b
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDE1C COBLL1 CASZ1 SLC4A1 DOCK7 PCDH7 FYB2	5.64e-06	188	161	7	58ccb31cdf43167872ef0fc737e6f9c51ee2e060
ToppCell	droplet-Lung-30m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PRUNE2 MAK PLIN2 DST LPL LY75 DNAH11	5.84e-06	189	161	7	98f517af255ef234eefc3ed7e6c1d63331ab8af0
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH7 COBLL1 DGKB ITGB6 CASZ1 DST OCLN	5.84e-06	189	161	7	e32172ad09e93f6ac6ea2b92145b2b73003f7970
ToppCell	COVID-19-lung-Ciliated\|lung / Disease (COVID-19 only), tissue and cell type	CFAP47 PTPRT CCDC148 DNAH6 HYDIN FYB2 DNAH11	5.84e-06	189	161	7	27329c4661aebabd19fac7fe5dca263fe99d76f3
ToppCell	droplet-Lung-30m-Hematologic-myeloid-alveolar_macrophage\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PRUNE2 MAK PLIN2 DST LPL LY75 DNAH11	5.84e-06	189	161	7	f7e9b6e6a4de297b660a5b6c9a62f860c147185e
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE1C MYO6 CASZ1 SLC4A1 DOCK7 PCDH7 FYB2	5.84e-06	189	161	7	532aaf02b364c5c4f58a2021c7c21d86df3875c9
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF366 CD109 ATP8B1 F8 ADGRL4 BST2 PLCB4	6.04e-06	190	161	7	bf9bc57a605c7e3979bc4f7260e6fb92c3eb8690
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE1A COBLL1 PKP4 ITGB6 CCDC148 SLC35F5 HYDIN	6.04e-06	190	161	7	3fc9e18c7441c0ae8cda65753cc42d0520f4e116
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Artery\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PCSK5 CD109 ADGRL4 BMX CNTNAP4 PLCB4 PCDH10	6.04e-06	190	161	7	aed65d584ca0c25f6a8313c66b421a6618af82ea
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Artery\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PCSK5 CD109 ADGRL4 BMX CNTNAP4 PLCB4 PCDH10	6.25e-06	191	161	7	4b3d5157344dbfbf4fab518611cd9fa37fac7bd9
ToppCell	nucseq-Epithelial-Epithelial_Airway\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CFAP47 PTPRT CCDC148 DNAH6 HYDIN FYB2 DNAH11	6.25e-06	191	161	7	1c528f72c9ef3ef3a850b05e4a9715190832270c
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PCSK5 ZNF366 CD109 ADGRL4 BST2 CNTNAP4 PLCB4	6.47e-06	192	161	7	56b021c297a21dff357531f21e2464f85186106d
ToppCell	IPF-Epithelial-Ciliated\|IPF / Disease state, Lineage and Cell class	CFAP47 PTPRT CCDC148 DNAH6 HYDIN FYB2 DNAH11	6.47e-06	192	161	7	354adc1354bf596fbc60dd45c0169688e6f45165
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDE1C MYO6 COBLL1 ABHD3 ITGB6 PCDH7 FYB2	6.47e-06	192	161	7	f7e7491426bbd6ed29a465b58bf67acb93dbb90a
ToppCell	NS-moderate-d_0-4\|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CFAP47 TTC21A DNAH6 PCDH7 HYDIN FYB2 DNAH11	6.69e-06	193	161	7	ea345d34440b25f65358a53dc72831998d1c3620
ToppCell	COVID-19-Heart-CM_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	PDE1C TMEM71 INPP4B MLIP LPL PCDH7 FYB2	6.69e-06	193	161	7	dd5378a1ef8eb0eda9a3aae62f3c2f3a1402bda0
ToppCell	LPS-antiTNF-Endothelial-Endothelial\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDE1C MYO6 ZNF366 PKP4 CD109 ADGRL4 PLCB4	6.69e-06	193	161	7	02f633b016ab19bfa65bfd0cf32f000549a62148
ToppCell	LPS-antiTNF-Endothelial\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDE1C MYO6 ZNF366 PKP4 CD109 ADGRL4 PLCB4	6.69e-06	193	161	7	5122b1ffba42de190061be34ecdc6176f84e56a3
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDE1A COBLL1 ITGB6 SLC35F5 PARP4 OCLN HYDIN	6.92e-06	194	161	7	e577d9e88390b36b5a09b97fe1026089892275a3
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DMGDH PDE1A COBLL1 PKP4 CASZ1 CCDC148 HYDIN	6.92e-06	194	161	7	93c68c31e39fa44c1d05d7d4997f4f086da4e738
ToppCell	LPS-IL1RA-Endothelial\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDE1C MYO6 PKP4 CD109 ADGRL4 DST PLCB4	6.92e-06	194	161	7	43f92b0533e26633dc94cce554045d641ef8fd76
ToppCell	LPS-IL1RA-Endothelial-Endothelial\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDE1C MYO6 PKP4 CD109 ADGRL4 DST PLCB4	6.92e-06	194	161	7	1d39d968730a7e85b6161c1c8a6bd38afe9bcad7
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE1A CYSLTR2 MYO6 ATP8B1 INPP4B PCDH7 FYB2	6.92e-06	194	161	7	4579b4a44f7c731553a284843c296866027d7c0e
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 DOCK11 SLC35F5 PARP4 KCNB1 AMOT SDC2	6.92e-06	194	161	7	8ddcaaf24cee6e30d5be52c0cbf778cfba309c53
ToppCell	IPF-Multiplet-Multiplet\|IPF / Disease state, Lineage and Cell class	CFAP47 PTPRT PLCB4 DNAH6 HYDIN FYB2 DNAH11	7.16e-06	195	161	7	fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell	IPF-Multiplet\|IPF / Disease state, Lineage and Cell class	CFAP47 PTPRT PLCB4 DNAH6 HYDIN FYB2 DNAH11	7.16e-06	195	161	7	eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell	IPF-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	CFAP47 PTPRT PLCB4 DNAH6 HYDIN FYB2 DNAH11	7.16e-06	195	161	7	21dbdc803c6947024dc2416e9e21c2ef0af9bc31
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDE1A MYO6 COBLL1 PKP4 ITGB6 CASZ1 CCDC148	7.16e-06	195	161	7	6477e6e7be5bd8eb99119a12ae16334ccddecd43
ToppCell	IPF-Epithelial\|IPF / Disease state, Lineage and Cell class	CFAP47 CLDN4 PTPRT DNAH6 HYDIN FYB2 DNAH11	7.40e-06	196	161	7	87d9881cfec461a5d89b688a83749b618c519485
ToppCell	Control_saline-Endothelial-Endothelial-Artery\|Control_saline / Treatment groups by lineage, cell group, cell type	PCSK5 ADGRL4 BMX DST CNTNAP4 PLCB4 PCDH10	8.45e-06	200	161	7	65b71f1e8da5c3750fcd0a2e66d9ef3125a3f78a
ToppCell	Neuronal-Excitatory-eB(RORB)-SEMA3E-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	PRUNE2 PDE1A PDE1C PTPRT PARP4 DNAH6 PCDH7	8.45e-06	200	161	7	1a3d29a580d1b405a74869a1da3e818c581fc559
ToppCell	Neuronal-Excitatory-eB(RORB)-SEMA3E---L4-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	PRUNE2 PDE1A PDE1C PTPRT PARP4 DNAH6 PCDH7	8.45e-06	200	161	7	6f9ed8fe9cda91185c3a1a675353e11b8fec6ef1
ToppCell	Neuronal-Excitatory-eB(RORB)-SEMA3E--\|Neuronal / cells hierarchy compared to all cells using T-Statistic	PRUNE2 PDE1A PDE1C PTPRT PARP4 DNAH6 PCDH7	8.45e-06	200	161	7	86705dfc05b3e1576543b93883c88fb55b742855
ToppCell	Neuronal-Excitatory-eB(RORB)-SEMA3E\|Neuronal / cells hierarchy compared to all cells using T-Statistic	PRUNE2 PDE1A PDE1C PTPRT PARP4 DNAH6 PCDH7	8.45e-06	200	161	7	db194b4f524fd008b3c5b4b6014b436190a1b87a
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	ZNF366 ADGRL4 BMX OCLN LY75 G6PC1	9.01e-06	133	161	6	bc29a2faa151b0e48c1c7e3f016cccc49f9a15eb
ToppCell	TCGA-Bladder-Solid_Tissue_Normal-Urothelial_normal_tissue-Urothelial_normal_tissue-2\|TCGA-Bladder / Sample_Type by Project: Shred V9	PRUNE2 DMGDH PDE1C DGKB GLP2R KCNB1	1.26e-05	141	161	6	1baa054c2ae3b446d1954244b7fbf8af824ef345
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_STALK\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	ZNF366 ADGRL4 BMX OCLN LY75 G6PC1	1.36e-05	143	161	6	35d3652680c4dddd293301595d813161c66e5673
ToppCell	COVID-19-kidney-Technical/muscle_(Imm)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	KCNH7 TOPAZ1 PTPRT CNTNAP4 ABCB11 MPPED1	1.79e-05	150	161	6	0205318a870e091add66ee4305747dda9f51510d
ToppCell	COVID-19-Epithelial_cells-Airway_mucous\|COVID-19 / group, cell type (main and fine annotations)	CFAP47 PTPRT CCDC148 DNAH6 HYDIN DNAH11	1.86e-05	151	161	6	8216462e723fec2797387929dde095370947e10a
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE1A PDE1C COBLL1 CASZ1 SLC4A1 FYB2	3.06e-05	165	161	6	9bd332e5ede759a00a47728ea5558c215efdd77a
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PCSK5 PDE1C ATP8B1 BMX DST MBD4	3.16e-05	166	161	6	7a45785a40b7425f97be67bab1c5ceb69b2bd85a
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PCSK5 PDE1C ATP8B1 BMX DST MBD4	3.16e-05	166	161	6	bbd382812f8a84a5d99888de2d7cca3a8b5e4695
Drug	Neostigmine bromide [114-80-7]; Down 200; 13.2uM; PC3; HT_HG-U133A	PDE1C ZNF148 MYO6 RBL2 PKP4 CEP350 PRRC2C PDP1 KMT2A SPEN ANAPC5	9.67e-08	188	160	11	6735_DN
Drug	Etifenin [63245-28-3]; Down 200; 12.4uM; PC3; HT_HG-U133A	ZNF148 MYO6 RBL2 PKP4 ESF1 CEP350 PRRC2C PDP1 KMT2A SPEN	5.48e-07	178	160	10	3998_DN
Drug	testosterone enanthate	PRUNE2 PDE1C ZNF148 RBL2 ATP8B1 ESF1 FANCC PPP1R3A JAK2 CLCN3 AMOT PRRC2C PDP1 KMT2A MBD4 SPEN ANAPC5	6.67e-07	575	160	17	ctd:C004648
Drug	Cloperastine hydrochloride [14984-68-0]; Down 200; 11uM; PC3; HT_HG-U133A	RBL2 PKP4 PRPF6 CEP350 JAK2 PACS1 CLCN3 KMT2A SPEN ANAPC5	9.49e-07	189	160	10	4271_DN
Disease	low density lipoprotein cholesterol measurement, alcohol consumption measurement	PCSK5 COBLL1 BUD13 DOCK7 ABCB11 DNAH11	1.71e-05	99	160	6	EFO_0004611, EFO_0007878
Disease	X-23636 measurement	DMGDH SLC6A12	2.92e-05	2	160	2	EFO_0800852
Disease	Autoimmune Diseases	PTPN22 F8 ITGB6 C4B	7.94e-05	42	160	4	C0004364
Disease	Progressive intrahepatic cholestasis (disorder)	ATP8B1 ABCB11	8.73e-05	3	160	2	C0268312
Disease	Progressive familial intrahepatic cholestasis type 3	ATP8B1 ABCB11	8.73e-05	3	160	2	cv:C1865643
Disease	Cholestasis, benign recurrent intrahepatic 1	ATP8B1 ABCB11	8.73e-05	3	160	2	C4551899
Disease	acute lymphoblastic leukemia, response to antineoplastic agent	DGKB NOX3 INPP4B	1.42e-04	19	160	3	EFO_0000220, GO_0097327
Disease	intrahepatic cholestasis (is_implicated_in)	ATP8B1 ABCB11	1.74e-04	4	160	2	DOID:1852 (is_implicated_in)
Disease	Cholestasis, progressive familial intrahepatic 1	ATP8B1 ABCB11	1.74e-04	4	160	2	C4551898
Disease	cholesterol to total lipids in large HDL percentage	DMGDH COBLL1 LPL DOCK7	2.29e-04	55	160	4	EFO_0022234
Disease	low density lipoprotein cholesterol measurement, alcohol drinking	PCSK5 BUD13 DOCK7 ABCB11 DNAH11	2.40e-04	102	160	5	EFO_0004329, EFO_0004611
Disease	insulin sensitivity measurement	DMGDH SLC6A12 ARMC8	2.56e-04	23	160	3	EFO_0004471
Disease	triglycerides to total lipids in small LDL percentage	DMGDH COBLL1 LPL DOCK7	3.00e-04	59	160	4	EFO_0022337
Disease	triglycerides in small VLDL measurement	DMGDH COBLL1 LPL DOCK7	3.42e-04	61	160	4	EFO_0022145
Disease	triglycerides in small HDL measurement	DMGDH COBLL1 LPL DOCK7	3.64e-04	62	160	4	EFO_0022158
Disease	triglycerides to total lipids in IDL percentage	DMGDH COBLL1 LPL DOCK7	3.87e-04	63	160	4	EFO_0022329
Disease	triglycerides to total lipids in medium VLDL percentage	DMGDH COBLL1 LPL DOCK7	3.87e-04	63	160	4	EFO_0022335
Disease	cholesterol to total lipids in medium VLDL percentage	DMGDH COBLL1 LPL DOCK7	3.87e-04	63	160	4	EFO_0022239
Disease	free cholesterol to total lipids in medium LDL percentage	DMGDH COBLL1 LPL DOCK7	3.87e-04	63	160	4	EFO_0022283
Disease	cholesteryl esters to total lipids in medium VLDL percentage	DMGDH COBLL1 LPL DOCK7	4.11e-04	64	160	4	EFO_0022253
Disease	Neonatal Alloimmune Thrombocytopenia	CD109 ITGB3	4.32e-04	6	160	2	C3853779
Disease	FNAITP	CD109 ITGB3	4.32e-04	6	160	2	C3854603
Disease	diacylglycerol 36:1 measurement	BUD13 LPL	4.32e-04	6	160	2	EFO_0010354
Disease	cholesterol to total lipids in very small VLDL percentage	DMGDH COBLL1 LPL DOCK7	4.89e-04	67	160	4	EFO_0022245
Disease	triglycerides to total lipids in very small VLDL percentage	DMGDH COBLL1 LPL DOCK7	5.47e-04	69	160	4	EFO_0022341
Disease	Crohn's disease (is_implicated_in)	PTPN22 JAK2 OCLN	5.70e-04	30	160	3	DOID:8778 (is_implicated_in)
Disease	diacylglycerol 34:0 measurement	BUD13 LPL	6.03e-04	7	160	2	EFO_0020058
Disease	Intrahepatic Cholestasis	ATP8B1 ABCB11	6.03e-04	7	160	2	C0008372
Disease	cholesteryl esters to total lipids in very small VLDL percentage	DMGDH COBLL1 LPL DOCK7	6.10e-04	71	160	4	EFO_0022259
Disease	free cholesterol to total lipids in large LDL percentage	DMGDH COBLL1 LPL DOCK7	7.13e-04	74	160	4	EFO_0022280
Disease	free cholesterol to total lipids in small VLDL percentage	DMGDH COBLL1 LPL DOCK7	7.50e-04	75	160	4	EFO_0022287
Disease	Cholestasis of pregnancy	ATP8B1 ABCB11	8.01e-04	8	160	2	C0268318
Disease	myelofibrosis (is_implicated_in)	JAK2 KMT2A	8.01e-04	8	160	2	DOID:4971 (is_implicated_in)
Disease	level of Triacylglycerol (53:4) in blood serum	BUD13 LPL	8.01e-04	8	160	2	OBA_2045166
Disease	Uveal melanoma	CYSLTR2 PLCB4	8.01e-04	8	160	2	C0220633
Disease	plasma betaine measurement	DMGDH SLC6A12 LY75	8.28e-04	34	160	3	EFO_0007787
Disease	non-alcoholic fatty liver disease (implicated_via_orthology)	PLIN2 JAK2 LPL	9.80e-04	36	160	3	DOID:0080208 (implicated_via_orthology)
Disease	phospholipid measurement	KCNH7 ABHD3 LPL DOCK7 ABCB11	1.02e-03	140	160	5	EFO_0004639
Disease	triglyceride measurement, blood pressure	BUD13 LPL	1.03e-03	9	160	2	EFO_0004325, EFO_0004530
Disease	diacylglycerol 36:4 measurement	BUD13 LPL	1.03e-03	9	160	2	EFO_0020063
Disease	cholesteryl esters to total lipids in medium LDL percentage	COBLL1 LPL DOCK7	1.06e-03	37	160	3	EFO_0022252
Disease	creatinine measurement	DMGDH NACA2 PDE1A GATM SNUPN CASZ1 PPP1R3A MLIP PRRC2C LPL DOCK7 SYT1 MBD4 SHISA8	1.09e-03	995	160	14	EFO_0004518
Disease	acute myeloid leukemia (is_implicated_in)	ITGB3 FANCC JAK2 KMT2A	1.15e-03	84	160	4	DOID:9119 (is_implicated_in)
Disease	Graves' disease (is_implicated_in)	PTPN22 C4A C4B	1.24e-03	39	160	3	DOID:12361 (is_implicated_in)
Disease	diacylglycerol 32.2 measurement	BUD13 LPL	1.28e-03	10	160	2	EFO_0020055
Disease	oleoyl-linoleoyl-glycerol (18:1/18:2) [2] measurement	LPL DOCK7	1.28e-03	10	160	2	EFO_0800333
Disease	cholesteryl esters to total lipids in small LDL percentage	COBLL1 LPL DOCK7	1.54e-03	42	160	3	EFO_0022255
Disease	Peptic ulcer and gastro-oesophageal reflux disease (GORD) drug use measurement	TERF1 DNAH11	1.56e-03	11	160	2	EFO_0009923
Disease	aspirin-induced respiratory disease (is_implicated_in)	CYSLTR2 FANCC	1.56e-03	11	160	2	DOID:0080822 (is_implicated_in)
Disease	diacylglycerol 34:3 measurement	BUD13 LPL	1.56e-03	11	160	2	EFO_0020059
Disease	oleoyl-linoleoyl-glycerol (18:1/18:2) [1] measurement	BUD13 LPL	1.56e-03	11	160	2	EFO_0800332
Disease	systemic lupus erythematosus (implicated_via_orthology)	MAN2A1 C4A C4B	1.65e-03	43	160	3	DOID:9074 (implicated_via_orthology)
Disease	triglycerides in large LDL measurement	COBLL1 LPL DOCK7	1.65e-03	43	160	3	EFO_0022319
Disease	very long-chain saturated fatty acid measurement	LVRN ATP8B1 DOCK7	1.76e-03	44	160	3	EFO_0006796
Disease	integral membrane protein 2B measurement	BUD13 LPL	1.86e-03	12	160	2	EFO_0802634
Disease	level of Diacylglycerol (18:1_18:2) in blood serum	BUD13 LPL	1.86e-03	12	160	2	OBA_2045171
Disease	esophagus squamous cell carcinoma (is_implicated_in)	PTPRT MBD4 SPEN	1.88e-03	45	160	3	DOID:3748 (is_implicated_in)
Disease	aspartate aminotransferase to alanine aminotransferase ratio	PRUNE2 COBLL1 PTPN22 ATP8B1 MLIP ABCB11	1.99e-03	239	160	6	EFO_0010934
Disease	triglyceride measurement, alcohol drinking	COBLL1 BUD13 LPL DOCK7	2.10e-03	99	160	4	EFO_0004329, EFO_0004530
Disease	level of Phosphatidylinositol (18:1_18:1) in blood serum	BUD13 DOCK7	2.19e-03	13	160	2	OBA_2045159
Disease	1-stearoyl-2-linoleoyl-GPI (18:0/18:2) measurement	BUD13 DOCK7	2.19e-03	13	160	2	EFO_0800413
Disease	apolipoprotein E measurement	BUD13 DOCK7	2.19e-03	13	160	2	EFO_0008029
Disease	Malignant neoplasm of breast	PCDHGB6 ZNF366 MTMR8 CD109 CLDN4 ATP8B1 PCDH20 INPP4B PPP1R3A OCLN SPEN ANAPC5 G6PC1 VPS13B	2.21e-03	1074	160	14	C0006142
Disease	triglyceride measurement, alcohol consumption measurement	COBLL1 BUD13 LPL DOCK7	2.26e-03	101	160	4	EFO_0004530, EFO_0007878
Disease	cholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement	COBLL1 LPL DLG4 SELENOI	2.43e-03	103	160	4	EFO_0008595, EFO_0020944
Disease	sleep duration, triglyceride measurement	COBLL1 BUD13 LPL DOCK7	2.51e-03	104	160	4	EFO_0004530, EFO_0005271
Disease	polyunsaturated fatty acids to total fatty acids percentage	COBLL1 LPL DOCK7	2.54e-03	50	160	3	EFO_0022303
Disease	Leukemia, Myelocytic, Acute	PTPRT INPP4B FANCC JAK2 KMT2A	2.58e-03	173	160	5	C0023467
Disease	polyunsaturated fatty acids to monounsaturated fatty acids ratio	COBLL1 LPL DOCK7	2.69e-03	51	160	3	EFO_0022302
Disease	cholesterol to total lipids in small HDL percentage	COBLL1 LPL DOCK7	2.69e-03	51	160	3	EFO_0022240
Disease	autoimmune thrombocytopenic purpura (is_implicated_in)	PTPN22 ITGB3	2.93e-03	15	160	2	DOID:8924 (is_implicated_in)
Disease	triglycerides in HDL measurement	COBLL1 LPL DOCK7	3.00e-03	53	160	3	EFO_0022317
Disease	free cholesterol to total lipids in small LDL percentage	COBLL1 LPL DOCK7	3.00e-03	53	160	3	EFO_0022286
Disease	cholesteryl esters to total lipids in very large VLDL percentage	COBLL1 LPL DOCK7	3.00e-03	53	160	3	EFO_0022258
Disease	total lipids in medium VLDL	COBLL1 LPL DOCK7	3.17e-03	54	160	3	EFO_0022153
Disease	triglycerides in medium HDL measurement	COBLL1 LPL DOCK7	3.17e-03	54	160	3	EFO_0022321
Disease	cholesterol to total lipids in very large VLDL percentage	COBLL1 LPL DOCK7	3.17e-03	54	160	3	EFO_0022244
Disease	1-stearoyl-2-arachidonoyl-GPI (18:0/20:4) measurement	BUD13 DOCK7	3.34e-03	16	160	2	EFO_0800184
Disease	diacylglycerol 36:2 measurement	BUD13 LPL	3.34e-03	16	160	2	EFO_0010355
Disease	response to methotrexate	ZNF148 INPP4B	3.34e-03	16	160	2	GO_0031427
Disease	diacylglycerol 44:7 measurement	BUD13 LPL	3.34e-03	16	160	2	EFO_0020069
Disease	triglycerides in medium VLDL measurement	COBLL1 LPL DOCK7	3.34e-03	55	160	3	EFO_0022155
Disease	leukemia	FANCC JAK2 KMT2A	3.34e-03	55	160	3	C0023418
Disease	free cholesterol to total lipids in very large HDL percentage	COBLL1 BUD13 LPL	3.34e-03	55	160	3	EFO_0022288
Disease	apolipoprotein B measurement	PCSK5 COBLL1 BUD13 CASZ1 LPL DOCK7 ABCB11 DLG4 HYDIN DNAH11	3.44e-03	663	160	10	EFO_0004615
Disease	insulin measurement	RBL2 COBLL1 CASZ1 ABCB11 SYT1 MPPED1	3.45e-03	267	160	6	EFO_0004467
Disease	triglycerides in large VLDL measurement	COBLL1 LPL DOCK7	3.51e-03	56	160	3	EFO_0022178
Disease	triglycerides in LDL measurement	COBLL1 LPL DOCK7	3.51e-03	56	160	3	EFO_0022320
Disease	triglycerides in very large VLDL measurement	COBLL1 LPL DOCK7	3.51e-03	56	160	3	EFO_0022325
Disease	triglycerides to total lipids in medium HDL percentage	COBLL1 LPL DOCK7	3.51e-03	56	160	3	EFO_0022333
Disease	triglycerides in chylomicrons and extremely large VLDL measurement	COBLL1 LPL DOCK7	3.51e-03	56	160	3	EFO_0022316
Disease	cholesteryl esters to total lipids in medium HDL percentage	COBLL1 LPL DOCK7	3.51e-03	56	160	3	EFO_0022251
Disease	Drug habituation	PDE1C MYO6 ZNF366 PACS1	3.61e-03	115	160	4	C0013170
Disease	Drug abuse	PDE1C MYO6 ZNF366 PACS1	3.61e-03	115	160	4	C0013146
Disease	Prescription Drug Abuse	PDE1C MYO6 ZNF366 PACS1	3.61e-03	115	160	4	C4316881
Disease	Substance-Related Disorders	PDE1C MYO6 ZNF366 PACS1	3.61e-03	115	160	4	C0236969
Disease	Drug Use Disorders	PDE1C MYO6 ZNF366 PACS1	3.61e-03	115	160	4	C0013222
Disease	Drug Dependence	PDE1C MYO6 ZNF366 PACS1	3.61e-03	115	160	4	C1510472
Disease	Substance Dependence	PDE1C MYO6 ZNF366 PACS1	3.61e-03	115	160	4	C0038580
Disease	Substance Use Disorders	PDE1C MYO6 ZNF366 PACS1	3.61e-03	115	160	4	C0038586

Protein segments in the cluster

Peptide	Gene	Start	Entry
GLKSTTNYVDFYSTK	PKP4	1161	Q99569
AKRLKTFVTYEPYSS	NAIP	61	Q13075
VRIADKKYYPSSQDS	BST2	146	Q10589
KKYYPSSQDSSSAAA	BST2	151	Q10589
YYKSIGPLLSSSDNF	ADGRL4	301	Q9HBW9
SFPKNSKYEYDPDIS	BUD13	311	Q9BRD0
DLYKNPTSSSEFYKA	AMOT	206	Q4VCS5
YSPSYDKDKSVLAFR	ELMOD3	26	Q96FG2
YPDLKSSILSEFYKF	CCDC148	221	Q8NFR7
YFVSSPFSLDLSKTK	C4B	361	P0C0L5
RYQSSPAKPDSSFYK	SLC4A1	346	P02730
SFNTPEYLKSTFSKT	CASZ1	421	Q86V15
SDSLYYPDSLFSVKQ	CREBRF	151	Q8IUR6
PEVFHYFKYSSKSDV	BMX	581	P51813
AKYVSDRPQAFKEYT	ARFGEF1	1351	Q9Y6D6
TPSLLLFVSSFYKEY	CNTNAP4	1051	Q9C0A0
VPFNYYTTSTALQKI	DNAH11	2536	Q96DT5
FYYLSSIAKKPQLVT	ABHD3	46	Q8WU67
SYTPSYAKAKISAAR	ABCB11	1036	O95342
LQFLAYTKTPQYKAS	DOT1L	496	Q8TEK3
LFVSALKSYLKTFSY	LVRN	521	Q6Q4G3
SPSSYILNEYSKLNS	BBS12	631	Q6ZW61
YKYSSDRKQFNLIPA	CAMSAP1	1556	Q5T5Y3
RIDKNSTASYLKNYP	COBLL1	691	Q53SF7
YYAEKDTPAKARTTT	ATP8B1	426	O43520
ERKVTPSKYSSLIYF	HJURP	376	Q8NCD3
YKTKSSYKAFAAIPT	MLIP	206	Q5VWP3
DSTDYAFLNKTYSIP	RBM44	101	Q6ZP01
AFLNKTYSIPYSESK	RBM44	106	Q6ZP01
TYSIPYSESKLKKES	RBM44	111	Q6ZP01
YKEPAKSSTQFGSYK	RIC1	56	Q4ADV7
TPLAIYNSISYKTFL	JAK2	196	O60674
VNDKRFYPESSYKST	OCLN	331	Q16625
TKYKADKTYPTTVAE	PTPN22	36	Q9Y2R2
SIKDYKINSNPYFSL	PCDHGB6	166	Q9Y5F9
PFKIYSSSNNYYKLV	PCDHGB6	391	Q9Y5F9
SLSKYQLSPNEYFSL	PCDHGB7	166	Q9Y5F8
PFKIHSSSNNYYKLV	PCDHGB7	391	Q9Y5F8
PFFRKLSSETYSQAK	NSUN2	636	Q08J23
EKIFYYFSNSPSKRL	RBL2	1071	Q08999
SVQAAGTQSSYPYKK	RBKS	301	Q9H477
LYPYTSQKDNELSFS	ABI3	316	Q9P2A4
LAYSKLSFSQVFKLY	ANAPC5	141	Q9UJX4
YIYKGFEKPTENSSA	ARPC5L	111	Q9BPX5
TYSYSQKVPQASKDL	PCDH20	356	Q8N6Y1
ASYSAKDTYSKPDSN	PARP15	596	Q460N3
SDLEPSTAYSFYIKA	IGDCC3	486	Q8IVU1
KKFSTFTEAPYSTRY	LEXM	46	Q3ZCV2
PTHKSLKAAYSFYNV	NMT1	411	P30419
KYKINKFLSSSLYTA	MAN2A1	541	Q16706
LKYKTPDFESTGLYS	GATM	151	P50440
PEDLYAFSYNPKSSK	MTMR8	106	Q96EF0
KFKAELADSQSPYYQ	IMPG1	246	Q17R60
KDKYVTALYFTFSSL	KCNH7	611	Q9NS40
KSVITYVSSLYDAFP	DST	241	Q03001
QFTGIKKYFNSYTLT	ATP5MK	11	Q96IX5
YYSPENTAKAKEVLS	INPP4B	401	O15327
EVNLTAYKPKYFTSA	ESF1	486	Q9H501
KLADPNKSYSSYKSS	PCSK5	1781	Q92824
LYRGSTSTFKNVTYK	ITGB6	761	P18564
PEVSTNKTYSFLIYT	LPL	381	P06858
NKKKYFLHTSTPLDY	PCDH7	481	O60245
YSPDYSLAAVDLKSF	PDE1A	486	P54750
AYASSSYAPSVSKKT	PDE1C	666	Q14123
FTTLKSLYYNTEKVS	NAA16	326	Q6N069
FTYVNEKLFSKPTYA	ENDOU	186	P21128
KDNKYVPYSESFSQV	DDHD2	121	O94830
KQSKDAPKSFTFDYS	KIF1C	41	O43896
EKYNVSSLEKYSPDS	LY75	931	O60449
SFPFNTSVVYKKTLF	F8	56	P00451
FYQPDLKYLSFTLTK	NLRP4	691	Q96MN2
YATLITYAINSSPAK	FOXJ2	71	Q9P0K8
YKELFSYPKHITSNT	PARP4	921	Q9UKK3
KSSFKNYYTIVTEAP	PCDH10	406	Q9P2E7
DLIKQDFYYFPSVSK	MPPED1	161	O15442
YYKSTSSAFRKSPSL	GAL3ST4	171	Q96RP7
SSKSGKAFSYYLPAV	NKD2	346	Q969F2
SKEASKLYFNSLRTY	PDP1	201	Q9P0J1
KATLQPEYSDKSLYT	POLA1	1376	P09884
KYLGSVDSKYSSSFL	PACS1	671	Q6VY07
SPLKSYSIYFQALSK	PTPRT	696	O14522
SLFSKYTNSKIPYFL	PPP1R3A	1066	Q16821
TLAAYKSPAYEALTF	NT5DC4	26	Q86YG4
ADYKSDESYTPSKIS	ANAPC10	81	Q9UM13
YFKYPSSVSAITDIK	ARMC8	331	Q8IUR7
VTLFSDFKPYKTSLN	CD109	151	Q6YHK3
SFYQAVKTYVLNPKS	DNAH6	1781	Q9C0G6
PIKFSANAVYSKYNI	HYDIN	3156	Q4G0P3
KDVVFYNSYSKRPDN	GLP2R	231	O95838
LPYYVTIFLTESNKS	KCNB1	271	Q14721
YSFPSKKSKARYLEE	CABIN1	951	Q9Y6J0
IDLQYSLAKSYASTP	DOCK11	1601	Q5JSL3
SCYKQVSSKLYSLPN	DOCK7	1096	Q96N67
SLTPLYKFSYSNLKE	CENPL	76	Q8N0S6
TAKKISTPSFSSYYK	DNAJC15	71	Q9Y5T4
TDYYSNTSVPLIKQF	G6PC1	91	P35575
TYFLRKFSKPTSALY	NDUFAF1	11	Q9Y375
KQLRFALKTYFPYTS	FANCC	331	Q00597
YTVYNLSPKSYRTAK	DNAJC6	106	O75061
YTDALLKPSASQYKS	CEP350	806	Q5VT06
SPSEFSQLQKYAEYS	DGKB	11	Q9Y6T7
YTNVYRVFSKDPQKS	GLYATL1B	71	A0A0U1RQE8
ISYSSFPSQKALKYL	ASIC5	386	Q9NY37
LKVAKPSNAYLSDSY	DLG4	241	P78352
STAPTSKQYYLKQSR	MAK	471	P20794
LYFSSKYNKEALSPP	MBD4	416	O95243
SYSIQKSLAFAYVPV	DMGDH	806	Q9UI17
PLYKEATSTFTNITY	ITGB3	771	P05106
DKYKYSAVDTNPLSL	SELENOI	16	Q9C0D9
RSEPQYFSSAKYAKE	KMT2A	626	Q03164
APSSSLQSIFKYFKK	FAM172BP	321	A6NC97
PVKYKTETLTAFLSY	CCDC168	5686	Q8NDH2
PSSAAYQKAPTKEFY	SDC2	186	P34741
INFFESSKLYTKYLS	CFAP47	1151	Q6ZTR5
SSKLYTKYLSSSPSN	CFAP47	1156	Q6ZTR5
PLKNQTYSFSPSKSY	C2CD5	286	Q86YS7
YFVSSPFSLDLSKTK	C4A	361	P0C0L4
ESKYVSLITSYQPFS	IFNGR1	301	P15260
PVVYSSFSSFYNTKK	AGPAT2	201	O15120
IKKNTLNPYYNESFS	SYT1	331	P21579
KHQFYPTVVYLTKSS	SYVN1	26	Q86TM6
AYVKSLFLSLASYFK	TMEM71	271	Q6P5X7
PTAFSYEKFYELTQK	PLCB4	201	Q15147
ISTFTYAYFLDKVSP	PRUNE2	36	Q8WUY3
SSELTSYVFTQYNKP	SLC35F5	86	Q8WV83
AIYAYALQVFPSKKS	PRPF6	561	O94906
YSRKEVPKLNYSSSL	FYB2	496	Q5VWT5
AKSLANVEYDTYKPT	MORC4	296	Q8TE76
ATFLFSLSKYTPLKY	SLC6A12	511	P48065
SLSKYTPLKYNNVYV	SLC6A12	516	P48065
FYSDKNAKLTKESYP	TENT5D	186	Q8NEK8
KYATLSLFNTYKGKS	PRRC2C	16	Q9Y520
TLQPDYAKYATFKAA	SHISA8	251	B8ZZ34
SSTKLRAPNYKTLFY	MTRES1	46	Q9P0P8
KQSSLASASFLPKYF	WDR45B	266	Q5MNZ6
PRLSQYKSKYSSLEQ	SNUPN	26	O95149
SEAQTPLKLSKVYFY	NOX3	426	Q9HBY0
SASYFLNRKLVYEPS	RWDD2A	131	Q9UIY3
VLKQYQLKYSETPFS	SIX6OS1	121	Q8N1H7
KPYSAKYSAARSAAA	CLDN4	191	O14493
YVFLQPYKKSTSVNV	CYSLTR2	61	Q9NS75
FSYLFPKYSTNEAKK	CLCN3	296	P51790
KVKGYRSLSTSQTFY	TLR8	866	Q9NR97
PKLKAFSMSSAYNAY	TAS1R1	376	Q7RTX1
FYSFALDKTITPDTK	SPEN	1431	Q96T58
TSLFYYIPKSALAAV	SLC26A11	396	Q86WA9
TLAFVYSPSKNALYE	TMEM181	551	Q9P2C4
YSPSKNALYESQLKD	TMEM181	556	Q9P2C4
FNYSYPTKQAALKSH	SLC38A2	26	Q96QD8
SDSYRAPTSIKEVYK	SMRP1	16	Q8NCR6
QFSKPDSKKSDYLYS	SPRED1	281	Q7Z699
KPIKAYSTENYSLES	FGD6	686	Q6ZV73
KVKDVQYIYTPFDSS	TIMP4	86	Q99727
TEKDPSYFVFLYLTK	PREPL	246	Q4J6C6
KSYVNYVLSEKSSTF	TERF1	241	P54274
VYEFQTPSYLTKSNS	RFX7	1211	Q2KHR2
YFTTTYNVVKPFLKS	RLBP1	246	P12271
DKAVQSYKDVFSYLP	TTC21A	906	Q8NDW8
SYKDVFSYLPTDNKV	TTC21A	911	Q8NDW8
YTIFKELFSSSSPSK	TIMM21	126	Q9BVV7
FYNKKSYSISPSFTK	TOPAZ1	761	Q8N9V7
PTCEKSYTSKYNLVT	ZNF366	256	Q8N895
YQASEYASSPVKTKT	VPS13B	1011	Q7Z7G8
SAYLSTKDQYPYLKS	PLIN2	31	Q99541
CLYSYVSKTPVQKFT	TESPA1	236	A2RU30
PASSKYKLKDSVYIF	GTF3C5	381	Q9Y5Q8
DKNDYLPLYSSSTKV	ZNF148	341	Q9UQR1
FDAISKTYSYLTPDL	RPS2	241	P15880
YYRTKEKLPLSSVSY	ZFC3H1	1161	O60293
SKSFSYQLEALKSKY	USP36	46	Q9P275
HLTSLKTKFPAEQYY	TSN	71	Q15631
YTNTYHIFTKAPDKL	GLYATL2	71	Q8WU03
ITKLDVYKSPASDAY	NACA2	106	Q9H009
FDIPKIYSSEAIKSY	MYO6	101	Q9UM54