Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontelomeric repeat-containing RNA binding

HNRNPA1L2 HNRNPA1

6.70e-053952GO:0061752
GeneOntologyMolecularFunctionRNA strand annealing activity

HNRNPA1L2 HNRNPA1

2.22e-045952GO:0033592
GeneOntologyMolecularFunctionspectrin binding

GBP1 GBP3 CAMSAP2

5.61e-0434953GO:0030507
GeneOntologyMolecularFunctionchromatin binding

ZC3H12A ACTN4 SUV39H2 CTCFL EHMT2 CHD5 ATAD2B KMT2A ATOH1 UTY DNMT1

7.66e-047399511GO:0003682
GeneOntologyMolecularFunctionhistone H3K9me2 methyltransferase activity

SUV39H2 EHMT2

9.83e-0410952GO:0140947
GeneOntologyMolecularFunctionG-rich strand telomeric DNA binding

HNRNPA1L2 HNRNPA1

1.20e-0311952GO:0098505
GeneOntologyMolecularFunctioninositol phosphate kinase activity

ITPKC PPIP5K2

1.20e-0311952GO:0180030
GeneOntologyMolecularFunctionDNA/DNA annealing activity

HNRNPA1L2 HNRNPA1

1.20e-0311952GO:1990814
GeneOntologyMolecularFunctionhistone H3 methyltransferase activity

SUV39H2 EHMT2 KMT2A

1.20e-0344953GO:0140938
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

SOX6 LHX4 ETV7 ACTN4 RELB LHX3 ZNF442 SUV39H2 ZNF440 HIVEP3 CTCFL EHMT2 NFKB2 ATOH1 ZNF564 UTY

1.37e-0314599516GO:0000977
GeneOntologyMolecularFunctionS-adenosylmethionine-dependent methyltransferase activity

SUV39H2 EHMT2 KMT2A TRMT5 DNMT1

1.39e-03172955GO:0008757
GeneOntologyMolecularFunctionGDP phosphatase activity

GBP1 GBP3

1.43e-0312952GO:0004382
GeneOntologyMolecularFunctionmiRNA binding

ZC3H12A HNRNPA1L2 HNRNPA1

1.55e-0348953GO:0035198
GeneOntologyMolecularFunctionhistone H3K9 methyltransferase activity

SUV39H2 EHMT2

1.69e-0313952GO:0046974
GeneOntologyMolecularFunctionsingle-stranded telomeric DNA binding

HNRNPA1L2 HNRNPA1

1.69e-0313952GO:0043047
GeneOntologyMolecularFunctionannealing activity

HNRNPA1L2 HNRNPA1

1.96e-0314952GO:0140666
GeneOntologyMolecularFunctionsequence-specific single stranded DNA binding

HNRNPA1L2 HNRNPA1

2.26e-0315952GO:0098847
GeneOntologyMolecularFunctionmicrotubule minus-end binding

NUMA1 CAMSAP2

2.26e-0315952GO:0051011
GeneOntologyBiologicalProcessepigenetic regulation of gene expression

RBM15 SUV39H2 CTCFL EHMT2 ATAD2B RBM15B KMT2A UTY DNMT1

1.67e-05330929GO:0040029
GeneOntologyBiologicalProcessmedial motor column neuron differentiation

LHX4 LHX3

1.97e-052922GO:0021526
GeneOntologyBiologicalProcessnegative regulation of gene expression, epigenetic

RBM15 SUV39H2 EHMT2 RBM15B KMT2A UTY DNMT1

3.48e-05203927GO:0045814
GeneOntologyBiologicalProcessneuron fate specification

LHX3 EHMT2 ATOH1 SUFU

3.64e-0542924GO:0048665
GeneOntologyBiologicalProcessmethylation

RBM15 SUV39H2 EHMT2 RBM15B KMT2A TRMT5 DNMT1

8.55e-05234927GO:0032259
GeneOntologyBiologicalProcessheterochromatin formation

RBM15 EHMT2 RBM15B KMT2A UTY DNMT1

9.04e-05163926GO:0031507
GeneOntologyBiologicalProcessresponse to potassium ion

HNRNPA1L2 HNRNPA1 KMT2A

1.08e-0421923GO:0035864
GeneOntologyBiologicalProcesspositive regulation of AIM2 inflammasome complex assembly

GBP1 GBP3

1.17e-044922GO:0140973
GeneOntologyBiologicalProcesscell differentiation in spinal cord

SOX6 LHX4 LHX3 SUFU

1.81e-0463924GO:0021515
GeneOntologyBiologicalProcesssomatic motor neuron differentiation

LHX4 LHX3

1.95e-045922GO:0021523
GeneOntologyBiologicalProcesscell fate specification

SOX6 LHX3 EHMT2 ATOH1 SUFU

2.26e-04123925GO:0001708
GeneOntologyBiologicalProcessregulation of AIM2 inflammasome complex assembly

GBP1 GBP3

2.92e-046922GO:0140971
GeneOntologyBiologicalProcesscellular response to sodium arsenite

ZC3H12A HNRNPA1

2.92e-046922GO:1903936
GeneOntologyBiologicalProcessalternative mRNA splicing, via spliceosome

RBM15 HNRNPA1L2 HNRNPA1 RBM15B

4.31e-0479924GO:0000380
GeneOntologyBiologicalProcesschromatin remodeling

RBM15 CHD9 SUV39H2 CTCFL EHMT2 CHD5 ATAD2B RBM15B KMT2A UTY DNMT1

4.55e-047419211GO:0006338
GeneOntologyBiologicalProcessmacromolecule methylation

RBM15 EHMT2 RBM15B KMT2A TRMT5

4.82e-04145925GO:0043414
GeneOntologyBiologicalProcesscell fate specification involved in pattern specification

LHX3 SUFU

5.41e-048922GO:0060573
GeneOntologyBiologicalProcesscellular response to salt

ZC3H12A HNRNPA1

5.41e-048922GO:1902075
GeneOntologyBiologicalProcessventral spinal cord interneuron specification

LHX3 SUFU

5.41e-048922GO:0021521
GeneOntologyBiologicalProcessAIM2 inflammasome complex assembly

GBP1 GBP3

5.41e-048922GO:0140970
GeneOntologyBiologicalProcessresponse to sodium arsenite

ZC3H12A HNRNPA1

5.41e-048922GO:1903935
GeneOntologyCellularComponenthost cell part

GBP1 GBP3

3.09e-046962GO:0033643
GeneOntologyCellularComponenthost intracellular part

GBP1 GBP3

3.09e-046962GO:0033646
GeneOntologyCellularComponenthost cell cytoplasm part

GBP1 GBP3

3.09e-046962GO:0033655
GeneOntologyCellularComponentsymbiont-containing vacuole

GBP1 GBP3

3.09e-046962GO:0020003
GeneOntologyCellularComponentsymbiont-containing vacuole membrane

GBP1 GBP3

3.09e-046962GO:0020005
GeneOntologyCellularComponenthost intracellular region

GBP1 GBP3

3.09e-046962GO:0043656
GeneOntologyCellularComponentnucleoplasmic periphery of the nuclear pore complex

HNRNPA1L2 HNRNPA1

3.09e-046962GO:1990826
GeneOntologyCellularComponenthost cell cytoplasm

GBP1 GBP3

3.09e-046962GO:0030430
GeneOntologyCellularComponentmicrotubule bundle

NUMA1 MARK2

3.09e-046962GO:0097427
GeneOntologyCellularComponentmicrotubule minus-end

NUMA1 CAMSAP2

4.32e-047962GO:0036449
GeneOntologyCellularComponentsymbiont cell surface

GBP1 GBP3

5.74e-048962GO:0106139
GeneOntologyCellularComponentother organism part

GBP1 GBP3

7.36e-049962GO:0044217
GeneOntologyCellularComponentRNA N6-methyladenosine methyltransferase complex

RBM15 RBM15B

7.36e-049962GO:0036396
GeneOntologyCellularComponentcell cortex region

NUMA1 MARK2 RIMS2

1.16e-0345963GO:0099738
GeneOntologyCellularComponentmethyltransferase complex

RBM15 RBM15B KMT2A UTY

1.55e-03108964GO:0034708
GeneOntologyCellularComponenthost cellular component

GBP1 GBP3

2.11e-0315962GO:0018995
HumanPhenoDecreased response to growth hormone stimulation test

LHX4 OCA2 LHX3 PREPL NFKB2 KMT2A SUFU

1.01e-05136307HP:0000824
HumanPhenoAbnormal response to endocrine stimulation test

LHX4 OCA2 LHX3 PREPL NFKB2 KMT2A SUFU

2.19e-05153307HP:0031073
HumanPhenoAbnormal growth hormone level

LHX4 OCA2 LHX3 PREPL NFKB2 KMT2A SUFU

2.28e-05154307HP:0032367
HumanPhenoDecreased circulating ACTH concentration

LHX4 LHX3 NFKB2 SUFU

2.41e-0530304HP:0002920
HumanPhenoAbnormal endocrine physiology

LHX4 OCA2 LHX3 PREPL NFKB2 KMT2A SUFU

2.48e-05156307HP:0031072
HumanPhenoDecreased circulating gonadotropin concentration

LHX4 OCA2 LHX3 SUFU

6.28e-0538304HP:0030339
HumanPhenoAnterior hypopituitarism

LHX4 OCA2 LHX3 PREPL NFKB2 KMT2A SUFU

6.71e-05182307HP:0000830
HumanPhenoHypopituitarism

LHX4 OCA2 LHX3 PREPL NFKB2 KMT2A SUFU

9.12e-05191307HP:0040075
HumanPhenoAbnormal circulating adrenocorticotropin concentration

LHX4 LHX3 NFKB2 SUFU

1.13e-0444304HP:0011043
HumanPhenoReduced circulating prolactin concentration

LHX4 LHX3 SUFU

2.63e-0422303HP:0008202
MousePhenotongue muscle hypoplasia

HNRNPA1L2 HNRNPA1

2.33e-052682MP:0030421
DomainPost-SET_dom

SUV39H2 EHMT2 KMT2A

6.18e-0516923IPR003616
DomainPostSET

SUV39H2 EHMT2 KMT2A

6.18e-0516923SM00508
DomainPOST_SET

SUV39H2 EHMT2 KMT2A

6.18e-0516923PS50868
DomainHnRNPA1

HNRNPA1L2 HNRNPA1

7.18e-053922PF11627
DomainHnRNPA1

HNRNPA1L2 HNRNPA1

7.18e-053922IPR021662
DomainSPOC_met

RBM15 RBM15B

7.18e-053922IPR010912
DomainSPOC

RBM15 RBM15B

1.43e-044922PS50917
DomainChromo_domain

CHD9 SUV39H2 CHD5

2.17e-0424923IPR023780
Domain-

RBM15 RBM15B

2.38e-0459222.40.290.10
DomainRHD_CS

RELB NFKB2

2.38e-045922IPR030492
DomainSPOC-like_C_dom

RBM15 RBM15B

2.38e-045922IPR016194
DomainIPT_NFkappaB

RELB NFKB2

2.38e-045922IPR033926
DomainChromo

CHD9 SUV39H2 CHD5

2.77e-0426923PF00385
DomainCHROMO_1

CHD9 SUV39H2 CHD5

3.47e-0428923PS00598
DomainCHROMO_2

CHD9 SUV39H2 CHD5

3.47e-0428923PS50013
DomainSPOC_C

RBM15 RBM15B

3.55e-046922IPR012921
DomainSPOC

RBM15 RBM15B

3.55e-046922PF07744
DomainPreSET

SUV39H2 EHMT2

4.96e-047922SM00468
DomainPre-SET

SUV39H2 EHMT2

4.96e-047922PF05033
DomainPre-SET_dom

SUV39H2 EHMT2

4.96e-047922IPR007728
DomainPRE_SET

SUV39H2 EHMT2

4.96e-047922PS50867
DomainChromodomain-like

CHD9 SUV39H2 CHD5

5.17e-0432923IPR016197
DomainChromo/shadow_dom

CHD9 SUV39H2 CHD5

5.67e-0433923IPR000953
DomainCHROMO

CHD9 SUV39H2 CHD5

5.67e-0433923SM00298
DomainZnf_FYVE-rel

FGD4 MTMR3 RIMS2

6.20e-0434923IPR017455
DomainZnf_FYVE_PHD

FGD4 CHD5 MTMR3 KMT2A RIMS2

8.01e-04147925IPR011011
DomainZnf_FYVE

FGD4 MTMR3 RIMS2

8.61e-0438923IPR000306
DomainZF_FYVE

FGD4 MTMR3 RIMS2

1.00e-0340923PS50178
DomainRHD_dimer

RELB NFKB2

1.05e-0310922IPR032397
DomainRHD_dimer

RELB NFKB2

1.05e-0310922PF16179
DomainNFkB/Dor

RELB NFKB2

1.05e-0310922IPR000451
DomainREL_1

RELB NFKB2

1.05e-0310922PS01204
DomainRHD_DNA_bind_dom

RELB NFKB2

1.05e-0310922IPR011539
DomainRHD_DNA_bind

RELB NFKB2

1.05e-0310922PF00554
DomainGBP_C

GBP1 GBP3

1.05e-0310922PF02841
DomainREL_2

RELB NFKB2

1.05e-0310922PS50254
Domain-

RELB NFKB2

1.05e-03109222.60.40.340
DomainSET

SUV39H2 EHMT2 KMT2A

1.08e-0341923PF00856
DomainZnf_CXXC

KMT2A DNMT1

1.28e-0311922IPR002857
DomainZF_CXXC

KMT2A DNMT1

1.28e-0311922PS51058
DomainG_GB1_RHD3_dom

GBP1 GBP3

1.28e-0311922IPR030386
Domainzf-CXXC

KMT2A DNMT1

1.28e-0311922PF02008
DomainGuanylate-bd_C

GBP1 GBP3

1.28e-0311922IPR003191
DomainGBP

GBP1 GBP3

1.28e-0311922PF02263
DomainGuanylate-bd_N

GBP1 GBP3

1.28e-0311922IPR015894
DomainG_GB1_RHD3

GBP1 GBP3

1.28e-0311922PS51715
DomainSET

SUV39H2 EHMT2 KMT2A

1.51e-0346923SM00317
DomainSET_dom

SUV39H2 EHMT2 KMT2A

1.92e-0350923IPR001214
DomainSET

SUV39H2 EHMT2 KMT2A

1.92e-0350923PS50280
DomainRRM_1

RBM15 RBM12B HNRNPA1L2 HNRNPA1 RBM15B

3.67e-03208925PF00076
DomainRRM

RBM15 RBM12B HNRNPA1L2 HNRNPA1 RBM15B

4.39e-03217925SM00360
PathwayREACTOME_PKMTS_METHYLATE_HISTONE_LYSINES

SUV39H2 EHMT2 NFKB2 KMT2A

3.96e-0546594MM14933
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

RBM15 TEX2 SRGAP2 LARP1B N4BP3 VPS13D PTPN13 KIAA1217 KMT2A MARK2 PPIP5K2 CAMSAP2 GARRE1 DNMT1

1.22e-07861971436931259
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

TEX2 ACTN4 LARP1B VPS13D PTPN13 NFKB2 SUFU CAMSAP2

1.36e-0720997836779422
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

RBM15 NUP85 SYNM RBM12B NUMA1 EVPL ACTN4 FLG2 HNRNPA1 PAICS ESF1 KIAA1217 CHD5 RBM15B MARK2 DNMT1

3.89e-071257971636526897
Pubmed

Matrix Metalloproteinase-9 gene induction by a truncated oncogenic NF-kappaB2 protein involves the recruitment of MLL1 and MLL2 H3K4 histone methyltransferase complexes.

RELB NFKB2 KMT2A

7.30e-07797319219072
Pubmed

N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.

RBM15 SYNM NUMA1 EVPL SRGAP2 PAICS EHMT2 KIAA1217 PPIP5K2

7.92e-0736097933111431
Pubmed

ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotency.

EHMT2 KMT2A DNMT1

2.49e-061097320569692
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

SOX6 SYNM CHD9 ACTN4 SRGAP2 PREPL DSCAML1 PAICS NAA25 PTPN13 EHMT2 SGSM2 MTMR3 GFPT2 DNMT1

2.72e-061285971535914814
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

NUP85 SYNM TEX2 PSMB1 LARP1B FLG2 HNRNPA1 PREPL ESF1 VPS13D EHMT2 KIAA1217 MRPL48 MTMR3 MARK2 TRMT5

3.74e-061496971632877691
Pubmed

Epigenetic mechanisms and metabolic reprogramming in fibrogenesis: dual targeting of G9a and DNMT1 for the inhibition of liver fibrosis.

EHMT2 DNMT1

7.70e-06297232327527
Pubmed

Post-translational modifications of hnRNP A1 differentially modulate retroviral IRES-mediated translation initiation.

HNRNPA1L2 HNRNPA1

7.70e-06297232960212
Pubmed

Avian Reticuloendotheliosis Viral Oncogene Related B Regulates Lymphatic Endothelial Cells during Vessel Maturation and Is Required for Lymphatic Vessel Function in Adult Mice.

RELB NFKB2

7.70e-06297231539516
Pubmed

siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.

HNRNPA1L2 HNRNPA1

7.70e-06297215215364
Pubmed

Phosphorylation of hnRNP A1-Serine 199 Is Not Required for T Cell Differentiation and Function.

HNRNPA1L2 HNRNPA1

7.70e-06297238334757
Pubmed

Constitutive alternative NF-kappaB signaling promotes marginal zone B-cell development but disrupts the marginal sinus and induces HEV-like structures in the spleen.

RELB NFKB2

7.70e-06297217620454
Pubmed

Retroviral insertions downstream of the heterogeneous nuclear ribonucleoprotein A1 gene in erythroleukemia cells: evidence that A1 is not essential for cell growth.

HNRNPA1L2 HNRNPA1

7.70e-0629721406633
Pubmed

Critical role of RelB serine 368 for dimerization and p100 stabilization.

RELB NFKB2

7.70e-06297212874295
Pubmed

The interferon-inducible GBP1 gene: structure and mapping to human chromosome 1.

GBP1 GBP3

7.70e-0629727518790
Pubmed

Stabilization of RelB requires multidomain interactions with p100/p52.

RELB NFKB2

7.70e-06297218321863
Pubmed

Molecular cloning and expression analysis of the mouse Spot-2 gene in pituitary development.

LHX4 LHX3

7.70e-06297212684778
Pubmed

Heterogeneous nuclear ribonucleoprotein A1 regulates rhythmic synthesis of mouse Nfil3 protein via IRES-mediated translation.

HNRNPA1L2 HNRNPA1

7.70e-06297228220845
Pubmed

Noncanonical NF-κB signaling regulates hematopoietic stem cell self-renewal and microenvironment interactions.

RELB NFKB2

7.70e-06297222290873
Pubmed

Lhx4 surpasses its paralog Lhx3 in promoting the differentiation of spinal V2a interneurons.

LHX4 LHX3

7.70e-06297238970652
Pubmed

Bone marrow stromal cells prevent apoptosis of lymphoma cells by upregulation of anti-apoptotic proteins associated with activation of NF-kappaB (RelB/p52) in non-Hodgkin's lymphoma cells.

RELB NFKB2

7.70e-06297217476277
Pubmed

Novel Pathological Role of hnRNPA1 (Heterogeneous Nuclear Ribonucleoprotein A1) in Vascular Smooth Muscle Cell Function and Neointima Hyperplasia.

HNRNPA1L2 HNRNPA1

7.70e-06297228912364
Pubmed

hnRNP A1 dysfunction in oligodendrocytes contributes to the pathogenesis of multiple sclerosis.

HNRNPA1L2 HNRNPA1

7.70e-06297236382566
Pubmed

Lysine methyltransferase G9a is required for de novo DNA methylation and the establishment, but not the maintenance, of proviral silencing.

EHMT2 DNMT1

7.70e-06297221427230
Pubmed

Carbon dioxide-dependent regulation of NF-κB family members RelB and p100 gives molecular insight into CO2-dependent immune regulation.

RELB NFKB2

7.70e-06297228507099
Pubmed

Pathophysiology of syndromic combined pituitary hormone deficiency due to a LHX3 defect in light of LHX3 and LHX4 expression during early human development.

LHX4 LHX3

7.70e-06297215567726
Pubmed

Targeting protein lysine methyltransferase G9A impairs self-renewal of chronic myelogenous leukemia stem cells via upregulation of SOX6.

SOX6 EHMT2

7.70e-06297233931742
Pubmed

Loss of hnRNP A1 in murine skeletal muscle exacerbates high-fat diet-induced onset of insulin resistance and hepatic steatosis.

HNRNPA1L2 HNRNPA1

7.70e-06297231169879
Pubmed

A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site.

RELB NFKB2

7.70e-0629721531086
Pubmed

Kaposi's sarcoma-associated herpesvirus ORF57 interacts with cellular RNA export cofactors RBM15 and OTT3 to promote expression of viral ORF59.

RBM15 RBM15B

7.70e-06297221106733
Pubmed

Constitutive activation of the alternative NF-κB pathway disturbs endochondral ossification.

RELB NFKB2

7.70e-06297230611922
Pubmed

Regulation of mouse hepatitis virus RNA synthesis by heterogeneous nuclear ribonucleoprotein A1.

HNRNPA1L2 HNRNPA1

7.70e-06297211774503
Pubmed

Role of hnRNP A1 in coronavirus RNA synthesis.

HNRNPA1L2 HNRNPA1

7.70e-06297211774505
Pubmed

NF-kappaB p52:RelB heterodimer recognizes two classes of kappaB sites with two distinct modes.

RELB NFKB2

7.70e-06297219098713
Pubmed

The A1 and A1B proteins of heterogeneous nuclear ribonucleoparticles modulate 5' splice site selection in vivo.

HNRNPA1L2 HNRNPA1

7.70e-0629728041722
Pubmed

Interplay between hnRNP A1 and a cis-acting element in the 3' UTR of CYP2A5 mRNA is central for high expression of the gene.

HNRNPA1L2 HNRNPA1

7.70e-06297212560094
Pubmed

Enzymatic nucleosome acetylation selectively affects activity of histone methyltransferases in vitro.

SUV39H2 EHMT2 KMT2A

9.34e-061597335907431
Pubmed

Human transcription factor protein interaction networks.

SOX6 LHX4 PSMB1 ETV7 NUMA1 RELB LHX3 FLG2 EHMT2 CHD5 NFKB2 KMT2A GFPT2 SUFU GARRE1

9.74e-061429971535140242
Pubmed

Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.

SUV39H2 EHMT2 KMT2A UTY

1.09e-054997434368113
Pubmed

Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

SYNM CHD9 N4BP3 MTMR3 GARRE1

1.12e-051049759205841
Pubmed

Ring1B and Suv39h1 delineate distinct chromatin states at bivalent genes during early mouse lineage commitment.

SUV39H2 EHMT2 ATOH1

1.39e-051797320573702
Pubmed

Heterogeneous Nuclear Ribonucleoprotein A1 Improves the Intestinal Injury by Regulating Apoptosis Through Trefoil Factor 2 in Mice with Anti-CD3-induced Enteritis.

HNRNPA1L2 HNRNPA1

2.31e-05397225901972
Pubmed

Phosphomimetic substitution of heterogeneous nuclear ribonucleoprotein A1 at serine 199 abolishes AKT-dependent internal ribosome entry site-transacting factor (ITAF) function via effects on strand annealing and results in mammalian target of rapamycin complex 1 (mTORC1) inhibitor sensitivity.

HNRNPA1L2 HNRNPA1

2.31e-05397221454539
Pubmed

PRMT5 regulates IRES-dependent translation via methylation of hnRNP A1.

HNRNPA1L2 HNRNPA1

2.31e-05397228115626
Pubmed

Sox6 is a candidate gene for p100H myopathy, heart block, and sudden neonatal death.

SOX6 OCA2

2.31e-05397210760285
Pubmed

The Alternative NF-κB Pathway in Regulatory T Cell Homeostasis and Suppressive Function.

RELB NFKB2

2.31e-05397229459403
Pubmed

Guanylate binding proteins facilitate caspase-11-dependent pyroptosis in response to type 3 secretion system-negative Pseudomonas aeruginosa.

GBP1 GBP3

2.31e-05397230062052
Pubmed

Reduced thymic Aire expression and abnormal NF-kappa B2 signaling in a model of systemic autoimmunity.

RELB NFKB2

2.31e-05397219234163
Pubmed

Regulation of naive T cell function by the NF-kappaB2 pathway.

RELB NFKB2

2.31e-05397216732290
Pubmed

Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages.

GBP1 GBP3

2.31e-05397226416908
Pubmed

Adipocyte-Specific Hnrnpa1 Knockout Aggravates Obesity-Induced Metabolic Dysfunction via Upregulation of CCL2.

HNRNPA1L2 HNRNPA1

2.31e-05397238320300
Pubmed

HnRNP A1 Suppresses the Odontogenic Differentiation and the Inclusion of RUNX2 Exon 5 of Dental Mesenchymal Cells.

HNRNPA1L2 HNRNPA1

2.31e-05397237525910
Pubmed

G9a and DNMT1 inhibition modulates CDKN1A promoter methylation and the cell cycle leading to improvement in kidney fibrosis.

EHMT2 DNMT1

2.31e-05397237356504
Pubmed

Guanylate-binding protein 2 orchestrates innate immune responses against murine norovirus and is antagonized by the viral protein NS7.

GBP1 GBP3

2.31e-05397232354743
Pubmed

Direct interaction between DNMT1 and G9a coordinates DNA and histone methylation during replication.

EHMT2 DNMT1

2.31e-05397217085482
Pubmed

GTPase properties of the interferon-induced human guanylate-binding protein 2.

GBP1 GBP3

2.31e-0539728706832
Pubmed

Guanylate binding proteins contained in the murine chromosome 3 are important to control mycobacterial infection.

GBP1 GBP3

2.31e-05397232620042
Pubmed

[Guanylate-binding protein 2 regulates the maturation of mouse dendritic cells induced by β-glucan].

GBP1 GBP3

2.31e-05397229089068
Pubmed

Differential subnuclear localization and replication timing of histone H3 lysine 9 methylation states.

SUV39H2 EHMT2

2.31e-05397215788566
Pubmed

HuR-regulated mRNAs associated with nuclear hnRNP A1-RNP complexes.

HNRNPA1L2 HNRNPA1

2.31e-05397224152440
Pubmed

Relative amounts of antagonistic splicing factors, hnRNP A1 and ASF/SF2, change during neoplastic lung growth: implications for pre-mRNA processing.

HNRNPA1L2 HNRNPA1

2.31e-05397215390079
Pubmed

Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers.

RELB NFKB2

2.31e-05397215470505
Pubmed

HNRNPA1-mediated exosomal sorting of miR-483-5p out of renal tubular epithelial cells promotes the progression of diabetic nephropathy-induced renal interstitial fibrosis.

HNRNPA1L2 HNRNPA1

2.31e-05397233692334
Pubmed

Cross-talk Between Histone and DNA Methylation Mediates Bone Loss in Hind Limb Unloading.

EHMT2 DNMT1

2.31e-05397233465813
Pubmed

Murine guanylate binding protein 2 (mGBP2) controls Toxoplasma gondii replication.

GBP1 GBP3

2.31e-05397223248289
Pubmed

Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP.

GBP1 GBP3

2.31e-0539721715024
Pubmed

Identification of a conserved protein that interacts with specific LIM homeodomain transcription factors.

LHX4 LHX3

2.31e-05397210788441
Pubmed

Two families of GTPases dominate the complex cellular response to IFN-gamma.

GBP1 GBP3

2.31e-0539729862701
Pubmed

RelB is the NF-kappaB subunit downstream of NIK responsible for osteoclast differentiation.

RELB NFKB2

2.31e-05397218322009
Pubmed

NF-κB2/p52:c-Myc:hnRNPA1 Pathway Regulates Expression of Androgen Receptor Splice Variants and Enzalutamide Sensitivity in Prostate Cancer.

HNRNPA1 NFKB2

2.31e-05397226056150
Pubmed

The interferon (IFN)-induced GTPase, mGBP-2. Role in IFN-gamma-induced murine fibroblast proliferation.

GBP1 GBP3

2.31e-05397211726669
Pubmed

Transcriptional repression by the HDAC4-RelB-p52 complex regulates multiple myeloma survival and growth.

RELB NFKB2

2.31e-05397226455434
Pubmed

GBP2 inhibits pathological angiogenesis in the retina via the AKT/mTOR/VEGFA axis.

GBP1 GBP3

2.31e-05397238636926
Pubmed

The Splicing Factor hnRNPA1 Regulates Alternate Splicing of the MYLK Gene.

HNRNPA1L2 HNRNPA1

2.31e-05397229077485
Pubmed

The NF-kappaB factor RelB and histone H3 lysine methyltransferase G9a directly interact to generate epigenetic silencing in endotoxin tolerance.

RELB EHMT2

2.31e-05397219690169
Pubmed

Molecular cloning of the genes suppressed in RVC lymphoma cells by topoisomerase inhibitors.

HNRNPA1L2 HNRNPA1

2.31e-0539728912629
Pubmed

A widespread sequence-specific mRNA decay pathway mediated by hnRNPs A1 and A2/B1.

HNRNPA1L2 HNRNPA1

2.31e-05397227151978
Pubmed

Resveratrol limits epithelial to mesenchymal transition through modulation of KHSRP/hnRNPA1-dependent alternative splicing in mammary gland cells.

HNRNPA1L2 HNRNPA1

2.31e-05397228088441
Pubmed

eIF2alpha phosphorylation tips the balance to apoptosis during osmotic stress.

HNRNPA1L2 HNRNPA1

2.31e-05397220338999
Pubmed

Alternative NF-κB signaling promotes colorectal tumorigenesis through transcriptionally upregulating Bcl-3.

RELB NFKB2

2.31e-05397229973688
Pubmed

NFkappaB1/p50 is not required for tumor necrosis factor-stimulated growth of primary mammary epithelial cells: implications for NFkappaB2/p52 and RelB.

RELB NFKB2

2.31e-05397217008396
Pubmed

DNA methylation-dependent regulation of BORIS/CTCFL expression in ovarian cancer.

CTCFL DNMT1

2.31e-05397218095639
Pubmed

Domain motions, dimerization, and membrane interactions of the murine guanylate binding protein 2.

GBP1 GBP3

2.31e-05397236639389
Pubmed

Quaking regulates Hnrnpa1 expression through its 3' UTR in oligodendrocyte precursor cells.

HNRNPA1L2 HNRNPA1

2.31e-05397221253564
Pubmed

Homocysteine facilitates endoplasmic reticulum stress and apoptosis of hepatocytes by suppressing ERO1α expression via cooperation between DNMT1 and G9a.

EHMT2 DNMT1

2.31e-05397235347798
Pubmed

Expression and function of the LIM homeobox containing genes Lhx3 and Lhx4 in the mouse placenta.

LHX4 LHX3

2.31e-05397218425848
Pubmed

TNFα-Induced Expression of Transport Protein Genes in HUVEC Cells Is Associated with Enhanced Expression of Transcription Factor Genes RELB and NFKB2 of the Non-Canonical NF-κB Pathway.

RELB NFKB2

2.31e-05397229658079
Pubmed

LncRNAH19 improves insulin resistance in skeletal muscle by regulating heterogeneous nuclear ribonucleoprotein A1.

HNRNPA1L2 HNRNPA1

2.31e-05397233115498
Pubmed

Noncanonical NF-κB pathway controls the production of type I interferons in antiviral innate immunity.

RELB NFKB2

2.31e-05397224656046
Pubmed

RelB/p52-mediated NF-κB signaling alters histone acetylation to increase the abundance of corticotropin-releasing hormone in human placenta.

RELB NFKB2

2.31e-05397226307012
Pubmed

Impairment of Mature B Cell Maintenance upon Combined Deletion of the Alternative NF-κB Transcription Factors RELB and NF-κB2 in B Cells.

RELB NFKB2

2.31e-05397226851215
Pubmed

Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway.

RELB NFKB2

2.31e-05397222864569
Pubmed

RelB/p52 NF-kappaB complexes rescue an early delay in mammary gland development in transgenic mice with targeted superrepressor IkappaB-alpha expression and promote carcinogenesis of the mammary gland.

RELB NFKB2

2.31e-05397216260626
Pubmed

Functional specificity of CpG DNA-binding CXXC domains in mixed lineage leukemia.

KMT2A DNMT1

2.31e-05397223990460
Pubmed

The interferon-induced GTPase, mGBP-2, confers resistance to paclitaxel-induced cytotoxicity without inhibiting multinucleation.

GBP1 GBP3

2.31e-05397216914101
Pubmed

Identification of an NKX3.1-G9a-UTY transcriptional regulatory network that controls prostate differentiation.

EHMT2 UTY

2.31e-05397227339988
Pubmed

hnRNP A1 and secondary structure coordinate alternative splicing of Mag.

HNRNPA1L2 HNRNPA1

2.31e-05397223704325
Pubmed

The GTPase activity of murine guanylate-binding protein 2 (mGBP2) controls the intracellular localization and recruitment to the parasitophorous vacuole of Toxoplasma gondii.

GBP1 GBP3

2.31e-05397222730319
InteractionYWHAH interactions

RBM15 TEX2 SRGAP2 LARP1B N4BP3 CEP128 VPS13D PTPN13 KIAA1217 MTMR3 RBM15B KMT2A NKTR MARK2 PPIP5K2 RIMS2 CAMSAP2 GARRE1 DNMT1

7.66e-0711029519int:YWHAH
InteractionZHX2 interactions

SOX6 LHX4 RELB LHX3 NFKB2

1.85e-0569955int:ZHX2
GeneFamilyAnkyrin repeat domain containing|NF-kappa B complex subunits

RELB NFKB2

1.11e-0456121254
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

SUV39H2 EHMT2 KMT2A

2.03e-0434613487
GeneFamilyZinc fingers CXXC-type

KMT2A DNMT1

7.23e-0412612136
GeneFamilyNon-clustered protocadherins

PCDH12 PCDH18

7.23e-041261221
GeneFamilyLIM class homeoboxes

LHX4 LHX3

7.23e-0412612522
GeneFamilyRNA binding motif containing

RBM15 RBM12B HNRNPA1L2 HNRNPA1 RBM15B

7.54e-04213615725
GeneFamilyZinc fingers FYVE-type|Pleckstrin homology domain containing|Rho guanine nucleotide exchange factors

FGD4 MTMR3

4.89e-033161281
ToppCellControl-Myeloid-TRAM2|Myeloid / Condition, Lineage and Cell class

ZC3H12A ETV7 GBP1 GBP3 RELB NFKB2

4.00e-06192976571fd71dad361a8b6c1bf9ad7184a89b3fbec667
ToppCellControl-Myeloid-TRAM2|Control / Condition, Lineage and Cell class

ZC3H12A ETV7 GBP1 GBP3 RELB NFKB2

4.24e-06194976d951dd1274d3ff1ac30671ec4153a4a8bc97b53f
DrugTrimethylcolchicinic acid [3482-37-9]; Up 200; 11.6uM; HL60; HT_HG-U133A

ETV7 RELB TNFRSF10D VPS13D ATAD2B NFKB2 CAMSAP2

1.72e-051929672146_UP
DrugSulfathiazole [72-14-0]; Down 200; 15.6uM; PC3; HT_HG-U133A

PSMB1 EVPL RELB PCDH12 NFKB2 NKTR UTY

2.03e-051979674183_DN
DrugPyrimethamine [58-14-0]; Down 200; 16uM; PC3; HT_HG-U133A

PSMB1 GBP1 PCDH12 HIVEP3 ITPKC VPS13D UTY

2.10e-051989674194_DN
Drugtetraethylenepentamine pentahydrochloride; Up 200; 100uM; MCF7; HG-U133A

OCA2 VPS13D ATAD2B NFKB2 MTMR3 KMT2A RIMS2

2.17e-05199967406_UP
DrugSparteine (-) [90-39-1]; Up 200; 17uM; HL60; HT_HG-U133A

NUMA1 TNFRSF10D OLFML2A PTPN13 NFKB2 CAMSAP2 UTY

2.24e-052009672134_UP
DrugBIX 01294

GBP1 GBP3 EHMT2

2.56e-0514963ctd:C518299
Diseaseneurodegenerative disease (implicated_via_orthology)

PSMB1 HNRNPA1L2 HNRNPA1 NFKB2 MARK2

8.85e-05145915DOID:1289 (implicated_via_orthology)
DiseaseCombined pituitary hormone deficiencies, genetic form

LHX4 LHX3

9.35e-055912cv:C4273747
Diseasediastolic blood pressure, unipolar depression

SOX6 NAA25 BANK1

1.08e-0430913EFO_0003761, EFO_0006336
Diseasepanhypopituitarism (is_implicated_in)

LHX4 LHX3

1.96e-047912DOID:9410 (is_implicated_in)
Diseasemean arterial pressure, alcohol drinking

SOX6 ZNF831 NAA25 BANK1

2.45e-0498914EFO_0004329, EFO_0006340
Diseasemean platelet volume

TEX2 ETV7 RTTN NUMA1 CHD9 ACTN4 HNRNPA1 DCANP1 FGD4 ATAD2B BANK1

3.03e-0410209111EFO_0004584
DiseaseChildhood Medulloblastoma

ATOH1 SUFU DNMT1

3.20e-0443913C0278510
DiseaseMelanotic medulloblastoma

ATOH1 SUFU DNMT1

3.20e-0443913C1275668
DiseaseMedullomyoblastoma

ATOH1 SUFU DNMT1

3.20e-0443913C0205833
DiseaseDesmoplastic Medulloblastoma

ATOH1 SUFU DNMT1

3.20e-0443913C0751291
DiseaseAdult Medulloblastoma

ATOH1 SUFU DNMT1

3.20e-0443913C0278876
Diseasehypertension

SOX6 ZNF831 FGD4 KCNK5 PCDH18 BANK1

3.84e-04307916EFO_0000537
Diseasealopecia areata (is_marker_for)

EHMT2 DNMT1

4.17e-0410912DOID:986 (is_marker_for)
DiseaseMedulloblastoma

ATOH1 SUFU DNMT1

5.01e-0450913C0025149
Diseasecortical thickness

MDM1 ACTN4 SRGAP2 VPS13D CBY2 MRPL48 MTMR3 KMT2A USP35 ATOH1 BANK1

6.28e-0411139111EFO_0004840
Diseasepreeclampsia, hypertension, pregnancy-induced

ACTN4 ZNF831

1.10e-0316912EFO_0000668, MONDO_0024664
Diseasenoggin measurement

HNRNPA1 SUFU

1.39e-0318912EFO_0021995
Diseaseperipheral neuropathy, response to antimicrotubule agent

FGD4 CNGB1

2.28e-0323912EFO_0003100, EFO_0005260
Diseasefatty acid measurement

RELB CEP128 DSCAML1 TMEM132C NAA25 KMT2A

2.33e-03436916EFO_0005110
DiseaseCharcot-Marie-Tooth disease (implicated_via_orthology)

FGD4 MTMR3

2.48e-0324912DOID:10595 (implicated_via_orthology)
Diseaseinfluenza A (H1N1)

NUMA1 CEP128 ATAD2B

2.49e-0387913EFO_1001488
DiseaseAcute kidney injury

GBP1 GBP3

2.69e-0325912HP_0001919
Diseaseplatelet measurement

RTTN CHD9 ACTN4 FGD4 BANK1

2.95e-03315915EFO_0005036

Protein segments in the cluster

PeptideGeneStartEntry
IPTDLRAKHSGEISE

BANK1

166

Q8NDB2
PSGTQDELHSSRRKT

DCANP1

106

Q8TF63
HRGTRSLPTVEVTEK

CEP128

26

Q6ZU80
HRSPSELEAERTSGA

CTCFL

41

Q8NI51
KERGESSCDRLTDPH

CTAGE1

541

Q96RT6
IHSRGDSSELRPDDT

CHD5

1656

Q8TDI0
HSTREKDRGPTKATT

DNMT1

606

P26358
GSLTHSRREALEKTE

ACTN4

506

O43707
DRDAKGETPISIAHR

ANKRD60

281

Q9BZ19
RVHGSLGDTPRSEET

EHMT2

36

Q96KQ7
KREDPHGTRTSDDTP

CD163L1

1416

Q9NR16
VKEGDVLRRSEEHSP

RBM12B

241

Q8IXT5
SREDSQRPGAHLTVK

HNRNPA1L2

91

Q32P51
TPERSRKENHSSEGT

RBM15B

631

Q8NDT2
ERDRKHRTTAPTEGK

RBM15

726

Q96T37
ASSEKGDLLDSPHIR

OCA2

151

Q04671
ELNSSDPHGIESKRR

RELB

421

Q01201
RTEGSSLHSEPERAG

ITPKC

61

Q96DU7
IAEDRGTPSLSTVKH

PCDH18

436

Q9HCL0
VTSVDHLRDSARKPG

PCDH12

696

Q9NPG4
SRDVRKTFEIHPISG

PCDHB18P

231

Q96TA0
ERINKSHISPSRESG

FLG2

206

Q5D862
SDGREDSVFAHPRKL

MAGEA12

231

P43365
EHGARRSKPFSELSD

JHY

201

Q6NUN7
PHSTGARKTETRVEE

ATAD2B

1096

Q9ULI0
RGRPISHSTTEDLKR

ESF1

56

Q9H501
TLRSKGHVSRSPDEE

KCNK5

361

O95279
DLTSRRPVHGESDTE

NUP85

606

Q9BW27
DPKLREEHSRLSGSL

EVPL

1381

Q92817
HSEVSTAELGKRAPR

FGD4

541

Q96M96
EASRVPKRTRSHSAD

MDM1

111

Q8TC05
PKRTRSHSADSRAEG

MDM1

116

Q8TC05
KPARHVREQLSSETG

LHX3

181

Q9UBR4
KPARHVREQLSSETG

LHX4

181

Q969G2
TELTHRIRSKSSPDE

GBP1

146

P32455
TELTHRIRSKSSPDE

GBP3

146

Q9H0R5
DLSVPAVEKSRSHGL

RIMS2

226

Q9UQ26
EEHKASLGREESRAP

CBY2

201

Q8NA61
PRVHKRGSESSSDSD

CHD9

2121

Q3L8U1
LERLTGHKSSPEAVT

HEATR5A

486

Q86XA9
TKDDFRHRAPSSGDV

ETV7

91

Q9Y603
SIHRVKRSASDDPSR

GFPT2

291

O94808
DSLHKARPEDVGTSL

DSCAML1

11

Q8TD84
RRKHSSGEQDTSTLP

GARRE1

941

O15063
ENSKTSPRSHRSDGE

ATOH1

326

Q92858
ASRLLKETEDGHESP

COPG2

236

Q9UBF2
SKDRVETLRPHVVGS

MARK2

661

Q7KZI7
SDSSETSVRGPRIKH

KMT2A

1056

Q03164
RLSEGFSIHTRDSPK

PSMB1

56

P20618
SVHSGKRTPRSESVE

CAMSAP2

1301

Q08AD1
HPGVLSERCTDEKSR

DIPK1C

46

Q0P6D2
PISDEFGRKRHSSTS

LARP1B

851

Q659C4
EATDLHGVSRSKTIP

LGSN

91

Q5TDP6
ESRRKTPEASAIGLH

MTMR3

726

Q13615
RRKHESDSSSIEDPG

PTPN13

1036

Q12923
SRLDPGDLSVHRETT

OLFML2A

551

Q68BL7
PRDRHEGRKQSTTEA

NUMA1

2016

Q14980
LRATPGSKTRVTSHD

GARIN3

541

Q8TC56
FHLTSEEGADTKRPL

RTTN

781

Q86VV8
KNRSLVPETSRHTGD

UTY

671

O14607
STEHSRITELLKPGD

TRMT5

286

Q32P41
AIRPGKDGLEETTSH

TMEM132C

251

Q8N3T6
FRHIRLGPTETETSE

SYNM

1401

O15061
PKGHSERSDTNEKRS

NKTR

256

P30414
EREAHPATRTKFSSG

SGSM2

621

O43147
PSRADSHVKDTRSGA

KIAA1217

1156

Q5T5P2
SSLPEGVRLSVKEHT

MRPL48

176

Q96GC5
STSPHKPDEGSRDRE

SOX6

96

P35712
SASGTHRKKLPSEDD

CNGB1

506

Q14028
RSLKEEECPAGSHRS

TNFRSF10D

76

Q9UBN6
ELRVTSAHKGPDETL

PAICS

296

P22234
PSSVRTHERTHTGEK

ZNF564

461

Q8TBZ8
RPSFRTQERDHTGEK

ZNF440

156

Q8IYI8
DTPLGDSRSHIKEEG

TEX13D

506

A0A0J9YY54
VKHGTATERERQTSP

ZC3H12A

86

Q5D1E8
DHRGSSSPRKESGRS

SRRM5

376

B3KS81
DLEGRTQHETTRDPS

SLC23A1

6

Q9UHI7
RHPDKTALIFEGTDT

SLC27A4

86

Q6P1M0
AATEARLHPEGSSRK

SOGA3

21

Q5TF21
ERGHKSRPTFSITKE

TMEM232

36

C9JQI7
SSDSIDHSPAKKRVR

SUV39H2

381

Q9H5I1
GSSRVRTEPTLHKDL

USP35

936

Q9P2H5
PESGSIRKTFRSDSH

SRGAP2

841

O75044
AHDRAPSRKDSLESD

SUFU

336

Q9UMX1
APRAHVLSKLEGTTD

HIVEP3

2046

Q5T1R4
TGHEDPITKTSRVLR

PREPL

431

Q4J6C6
SSLRRHETTHTGEKP

ZNF442

446

Q9H7R0
GSRDPSTEVHVRAIK

TAS2R8

221

Q9NYW2
HGCPKTSSEEEDSRR

PPIP5K2

486

O43314
EPTKHGETVARRGDS

ZNF831

706

Q5JPB2
SREDSQRPGAHLTVK

HNRNPA1

91

P09651
RSDHPKSTGEPTREI

TEX2

366

Q8IWB9
KNSRATEEEPHRGAT

SHE

121

Q5VZ18
HPSSESLTSEDGRIK

TIGD7

301

Q6NT04
DRGLLESSTRLKPHE

TMEM163

66

Q8TC26
HSLRKTTSTEEPRGT

VPS13D

2086

Q5THJ4
HSRAGDFSKTSLPER

N4BP3

91

O15049
TEESKSSRHLRGPHL

NAA25

311

Q14CX7
EKDTRSSFRGHTPLD

NFKB2

721

Q00653