Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionforked DNA-dependent helicase activity

WRN BLM

4.01e-0521272GO:0061749
GeneOntologyMolecularFunctioninositol 1,4,5 trisphosphate binding

TRPC3 TRPC5 PLCD1

8.69e-05141273GO:0070679
GeneOntologyMolecularFunction8-hydroxy-2'-deoxyguanosine DNA binding

WRN BLM

1.20e-0431272GO:1905773
GeneOntologyMolecularFunctiontelomeric G-quadruplex DNA binding

WRN BLM

1.20e-0431272GO:0061849
GeneOntologyMolecularFunctionY-form DNA binding

WRN BLM

2.39e-0441272GO:0000403
GeneOntologyMolecularFunctiontelomeric D-loop binding

WRN BLM

2.39e-0441272GO:0061821
GeneOntologyMolecularFunctionDNA/RNA hybrid binding

POLR1A POLR3A

3.96e-0451272GO:0071667
GeneOntologyMolecularFunctionD-loop DNA binding

WRN BLM

5.92e-0461272GO:0062037
GeneOntologyMolecularFunctionfour-way junction helicase activity

WRN BLM

5.92e-0461272GO:0009378
GeneOntologyMolecularFunctionthyroid hormone binding

PKM ALDH1A3

8.25e-0471272GO:0070324
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

TRPM6 SLC39A9 ATP13A1 TRPC3 TRPC5 CLIC4 NDUFB9 RYR1 CACNG3 SLC9B1 ATP6V0A2 GABRR3 GABRA5

1.09e-0375812713GO:0015318
GeneOntologyMolecularFunctionbubble DNA binding

WRN BLM

1.10e-0381272GO:0000405
HumanPhenoUnsteady gait

POMT2 RPGRIP1L WARS1 POLR1A TRPC3 DARS2 POLR3A B4GALT1 CLTC ATP6V0A2 SEMA3E GABRA5

3.16e-053574412HP:0002317
HumanPhenoAplasia/Hypoplasia of the cerebellar vermis

POMT2 RPGRIP1L POLR1A ZNF423 TRPC3 TRRAP ZEB2 POLR3A B4GALT1 ATP6V0A2 KNL1 SEMA3E

4.40e-053694412HP:0006817
HumanPhenoCerebellar vermis hypoplasia

POMT2 RPGRIP1L POLR1A ZNF423 TRPC3 TRRAP ZEB2 POLR3A B4GALT1 ATP6V0A2 KNL1 SEMA3E

4.40e-053694412HP:0001320
HumanPhenoAbnormal cerebellar vermis morphology

POMT2 RPGRIP1L POLR1A ZNF423 TRPC3 TRRAP ZEB2 POLR3A B4GALT1 ATP6V0A2 KNL1 SEMA3E

5.02e-053744412HP:0002334
HumanPhenoWebbed penis

ZEB2 POLR3A

7.29e-052442HP:0030264
MousePhenoabnormal physiological neovascularization

RNF213 CLIC4 B4GALT1 EPAS1

1.91e-05221044MP:0003710
DomainRQC

WRN BLM

4.37e-0521242SM00956
DomainRNA_pol_Rpb1_2

POLR1A POLR3A

1.31e-0431242PF00623
Domain-

WRN BLM

1.31e-04312421.10.150.80
DomainHRDC

WRN BLM

1.31e-0431242SM00341
DomainRNA_pol_asu

POLR1A POLR3A

1.31e-0431242IPR000722
DomainRNA_pol_N

POLR1A POLR3A

1.31e-0431242IPR006592
DomainRNA_pol_Rpb1_1

POLR1A POLR3A

1.31e-0431242PF04997
DomainRNA_pol_Rpb1_5

POLR1A POLR3A

1.31e-0431242PF04998
DomainRQC_domain

WRN BLM

1.31e-0431242IPR018982
DomainRNA_pol_Rpb1_3

POLR1A POLR3A

1.31e-0431242PF04983
DomainRNA_pol_Rpb1_4

POLR1A POLR3A

1.31e-0431242PF05000
DomainHRDC

WRN BLM

1.31e-0431242PS50967
DomainRPOLA_N

POLR1A POLR3A

1.31e-0431242SM00663
DomainRNA_pol_Rpb1_4

POLR1A POLR3A

1.31e-0431242IPR007083
DomainRNA_pol_Rpb1_5

POLR1A POLR3A

1.31e-0431242IPR007081
DomainRNA_pol_Rpb1_1

POLR1A POLR3A

1.31e-0431242IPR007080
DomainRNA_pol_Rpb1_3

POLR1A POLR3A

1.31e-0431242IPR007066
DomainRQC

WRN BLM

1.31e-0431242PF09382
DomainHRDC

WRN BLM

1.31e-0431242PF00570
DomainHRDC_dom

WRN BLM

2.60e-0441242IPR002121
DomainRecQ_Zn_bind

WRN BLM

2.60e-0441242PF16124
DomainRecQ_Zn-bd

WRN BLM

2.60e-0441242IPR032284
DomainHRDC-like

WRN BLM

4.32e-0451242IPR010997
DomainDNA_helicase_ATP-dep_RecQ

WRN BLM

4.32e-0451242IPR004589
DomainTRP_2

TRPC3 TRPC5

6.45e-0461242PF08344
DomainTRP_dom

TRPC3 TRPC5

6.45e-0461242IPR013555
DomainTRPC_channel

TRPC3 TRPC5

8.98e-0471242IPR002153
DomainMYTH4

ARHGAP39 PLEKHH1

1.53e-0391242PS51016
DomainMyTH4

ARHGAP39 PLEKHH1

1.53e-0391242SM00139
DomainMyTH4_dom

ARHGAP39 PLEKHH1

1.53e-0391242IPR000857
DomainMyTH4

ARHGAP39 PLEKHH1

1.53e-0391242PF00784
DomainMIR

POMT2 RYR1

1.90e-03101242PF02815
DomainMIR_motif

POMT2 RYR1

1.90e-03101242IPR016093
DomainMIR

POMT2 RYR1

1.90e-03101242PS50919
DomainMIR

POMT2 RYR1

1.90e-03101242SM00472
DomainTRP_channel

TRPC3 TRPC5

2.31e-03111242IPR004729
DomainFAD-dep_OxRdtase

SQLE KMO

2.76e-03121242IPR006076
DomainDAO

SQLE KMO

2.76e-03121242PF01266
Domain-

GART CPS1

3.25e-031312423.40.50.20
DomainATP_GRASP

GART CPS1

3.78e-03141242PS50975
DomainATP-grasp

GART CPS1

3.78e-03141242IPR011761
DomainPreATP-grasp_dom

GART CPS1

3.78e-03141242IPR016185
Domain-

GART CPS1

4.34e-031512423.30.1490.20
Domain-

SQLE KMO OSGIN2

6.13e-035612433.50.50.60
DomainATP_grasp_subdomain_1

GART CPS1

6.24e-03181242IPR013815
DomainEFTu-like_2

EEFSEC GTPBP1

6.24e-03181242IPR004161
Domain-

GART CPS1

6.24e-031812423.30.470.20
DomainGTP_EFTU_D2

EEFSEC GTPBP1

6.24e-03181242PF03144
DomainG_TR_2

EEFSEC GTPBP1

6.24e-03181242PS51722
DomainFAD/NAD-binding_dom

SQLE KMO OSGIN2

6.44e-03571243IPR023753
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

HIPK1 ZNF423 RAP1GAP2 DGKB FAM91A1 MED13L ZEB2 WDR47 PLEKHH1 CLTC LIMCH1 DOP1B

3.60e-084071271212693553
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

EEFSEC POLR1A ATP13A1 WRN FAM91A1 ARHGAP39 ANKHD1 TRRAP NDUFB9 CTTNBP2NL BLM ZBED6 VANGL1 STAU2 EMG1 PDCD11 DECR2 MRPL38 LIMCH1 UQCRC2 ATP6V0A2

1.17e-0714971272131527615
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

NR2C1 ADAM19 WARS1 ATP13A1 FOLH1 HIPK1 ZNF423 RHOBTB3 RAP1GAP2 CLIC4 MED13L UBASH3A ZEB2 WDR47 PLEKHH1 CLTC PKM MRPL38 DOP1B

2.26e-0712851271935914814
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

WARS1 POLR1A KEAP1 CPS1 ANKHD1 TRRAP DARS2 POLR3A STAU2 CLTC PKM PDCD11 UQCRC2 DYNC1I2

3.22e-077041271429955894
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

MBTD1 RPGRIP1L RHOBTB3 SQLE HM13 UBASH3A TRRAP DARS2 CAPN11 WDR47 APIP KMT5B VANGL1 STAU2 PXYLP1 DYNC1I2 DOP1B

2.95e-0612421271730973865
Pubmed

USP7 Regulates Cytokinesis through FBXO38 and KIF20B.

NR2C1 RPGRIP1L TRRAP ZEB2 BLM KNL1

4.50e-06116127630804394
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

EEFSEC RHOBTB3 FAM91A1 GTPBP1 ANKHD1 BCR POLR3A AACS EMG1 UQCRC2 HSD17B11 SEMA3E

5.00e-066501271238777146
Pubmed

Quantitative study of the interactome of PKCζ involved in the EGF-induced tumor cell chemotaxis.

KEAP1 TRRAP CLTC PKM AKAP11 MRPL38 EPAS1

5.42e-06184127723402259
Pubmed

WRN rescues replication forks compromised by a BRCA2 deficiency: Predictions for how inhibition of a helicase that suppresses premature aging tilts the balance to fork demise and chromosomal instability in cancer.

WRN BRCA2

1.32e-052127235751457
Pubmed

The Werner and Bloom syndrome proteins catalyze regression of a model replication fork.

WRN BLM

1.32e-052127217115688
Pubmed

Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins.

WRN BLM

1.32e-052127211919194
Pubmed

Defects in telomere maintenance molecules impair osteoblast differentiation and promote osteoporosis.

WRN BLM

1.32e-052127218028256
Pubmed

Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs.

WRN BLM

1.32e-052127210871376
Pubmed

BLM helicase facilitates telomere replication during leading strand synthesis of telomeres.

WRN BLM

1.32e-052127226195664
Pubmed

Distinct functions of human RECQ helicases WRN and BLM in replication fork recovery and progression after hydroxyurea-induced stalling.

WRN BLM

1.32e-052127223253856
Pubmed

The Werner and Bloom syndrome proteins help resolve replication blockage by converting (regressed) holliday junctions to functional replication forks.

WRN BLM

1.32e-052127221736299
Pubmed

Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes.

WRN BLM

1.32e-052127215367665
Pubmed

Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands.

WRN BLM

1.32e-052127211735402
Pubmed

TRPC3-interacting triadic proteins in skeletal muscle.

TRPC3 RYR1

1.32e-052127218215135
Pubmed

WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells.

WRN BRCA2

1.32e-052127234772932
Pubmed

Competition between the DNA unwinding and strand pairing activities of the Werner and Bloom syndrome proteins.

WRN BLM

1.32e-052127216412221
Pubmed

Enhancement of human DNA polymerase η activity and fidelity is dependent upon a bipartite interaction with the Werner syndrome protein.

WRN POLN

1.32e-052127223045531
Pubmed

BLM helicase facilitates RNA polymerase I-mediated ribosomal RNA transcription.

POLR1A BLM

1.32e-052127222106380
Pubmed

The roles of WRN and BLM RecQ helicases in the Alternative Lengthening of Telomeres.

WRN BLM

1.32e-052127222989712
Pubmed

Functional coupling between TRPC3 and RyR1 regulates the expressions of key triadic proteins.

TRPC3 RYR1

1.32e-052127216484216
Pubmed

The Werner syndrome protein is distinguished from the Bloom syndrome protein by its capacity to tightly bind diverse DNA structures.

WRN BLM

1.32e-052127222272300
Pubmed

The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases.

WRN BLM

1.32e-052127211433031
Pubmed

Bloom's syndrome: Why not premature aging?: A comparison of the BLM and WRN helicases.

WRN BLM

1.32e-052127227238185
Pubmed

RecQ family members combine strand pairing and unwinding activities to catalyze strand exchange.

WRN BLM

1.32e-052127215845538
Pubmed

Identification of different proteins binding to Na, K-ATPase α1 in LPS-induced ARDS cell model by proteomic analysis.

GTPBP4 RNF213 CPS1 CLTC PDCD11 UQCRC2

1.55e-05144127635681168
Pubmed

A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells.

EEFSEC GTPBP4 POLR1A WRN DARS2 POLR3A WDR47 NRXN3 UQCRC2

2.49e-05419127928700943
Pubmed

Zfp423/OAZ participates in a developmental switch during olfactory neurogenesis.

ZNF423 OR6A2 OR10A4

2.57e-0516127317521568
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

RHOBTB3 KEAP1 ANKHD1 BCR CTTNBP2NL NRXN3 MAST4 PDCD11 AKAP11 SEMA3E

2.60e-055291271014621295
Pubmed

Chromosomal location-dependent nonstochastic onset of odor receptor expression.

OR6A2 OR10A4 OR4F6

3.11e-0517127320668191
Pubmed

Dynamic regulation of sarcoplasmic reticulum Ca(2+) stores by stromal interaction molecule 1 and sarcolipin during muscle differentiation.

TRPC3 TRPC5 RYR1

3.11e-0517127322411552
Pubmed

Nuclear structure in normal and Bloom syndrome cells.

WRN BLM

3.96e-053127210779560
Pubmed

Turkish population data on the factor XIII Val34Leu,glycoprotein (GP)Ibalpha Kozak and P-selectin glycoprotein ligand 1 (PSGL-1) loci.

SELPLG GP1BA

3.96e-053127215386532
Pubmed

Stimulation of flap endonuclease-1 by the Bloom's syndrome protein.

WRN BLM

3.96e-053127214688284
Pubmed

Single-molecule imaging reveals a common mechanism shared by G-quadruplex-resolving helicases.

WRN BLM

3.96e-053127227407146
Pubmed

A functional link between store-operated and TRPC channels revealed by the 3,5-bis(trifluoromethyl)pyrazole derivative, BTP2.

TRPC3 TRPC5

3.96e-053127215647288
Pubmed

Integrated Proteomics and Metabolomics Analyses of Serum in Chinese Patients with Severe and Active Graves' Orbitopathy: A Cross-sectional Study.

CPS1 GP1BA

3.96e-053127236809953
Pubmed

Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality.

WRN BLM

3.96e-053127217961633
Pubmed

Human DNA2 possesses a cryptic DNA unwinding activity that functionally integrates with BLM or WRN helicases.

WRN BLM

3.96e-053127227612385
Pubmed

Coexpression of hypoxia-inducible factor-2α, TWIST2, and SIP1 may correlate with invasion and metastasis of salivary adenoid cystic carcinoma.

ZEB2 EPAS1

3.96e-053127222103974
Pubmed

Colorectal cancer and polymorphisms in DNA repair genes WRN, RMI1 and BLM.

WRN BLM

3.96e-053127219945966
Pubmed

POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates.

WRN BLM

3.96e-053127216030011
Pubmed

DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA end resection in human cells.

WRN BLM

3.96e-053127225122754
Pubmed

GTPBP4 promotes hepatocellular carcinoma progression and metastasis via the PKM2 dependent glucose metabolism.

GTPBP4 PKM

3.96e-053127236116159
Pubmed

Delineation of WRN helicase function with EXO1 in the replicational stress response.

WRN BLM

3.96e-053127220447876
Pubmed

CLIC1 and CLIC4 complement CA125 as a diagnostic biomarker panel for all subtypes of epithelial ovarian cancer.

MUC16 CLIC4

3.96e-053127230282979
Pubmed

Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1.

WRN BLM

3.96e-053127219734539
Pubmed

The processing of Holliday junctions by BLM and WRN helicases is regulated by p53.

WRN BLM

3.96e-053127212080066
Pubmed

HERC2 inactivation abrogates nucleolar localization of RecQ helicases BLM and WRN.

WRN BLM

3.96e-053127233432007
Pubmed

A polymorphism in Werner syndrome gene is associated with breast cancer susceptibility in Chinese women.

WRN BLM

3.96e-053127219205873
Pubmed

DNA-damage-induced type I interferon promotes senescence and inhibits stem cell function.

WRN BLM

3.96e-053127225921537
Pubmed

Hyperactivity of the transcription factor Nrf2 causes metabolic reprogramming in mouse esophagus.

KEAP1 PKM

3.96e-053127230409900
Pubmed

Anti-cancer fatty-acid derivative induces autophagic cell death through modulation of PKM isoform expression profile mediated by bcr-abl in chronic myeloid leukemia.

BCR PKM

3.96e-053127225644089
Pubmed

Functional interaction of p53 and BLM DNA helicase in apoptosis.

WRN BLM

3.96e-053127211399766
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

EEFSEC GTPBP4 ATP13A1 WRN FAM91A1 KEAP1 HM13 GTPBP1 ANKHD1 STAU2 CLTC PKM PDCD11 DECR2 LIMCH1 UQCRC2

4.15e-0513711271636244648
Pubmed

The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.

WARS1 FAM91A1 VANGL1 CLTC PKM LIMCH1 KNL1

4.55e-05256127733397691
Pubmed

Analysis of Presenilin 1 and 2 interacting proteins in mouse cerebral cortex during development.

MAST4 CLTC PKM

5.18e-0520127325196998
Pubmed

ETAA1 acts at stalled replication forks to maintain genome integrity.

WRN BLM BRCA2

6.03e-0521127327723720
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

MBTD1 RPGRIP1L SH3RF1 HIPK1 BCR SOX13 BLM BRCA2 CLTC KNL1

6.30e-055881271038580884
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

MBTD1 HIPK1 CPS1 ANKHD1 TRRAP ZEB2 DARS2 WDR47 BLM TBC1D32 PKM MRPL38

7.49e-058571271225609649
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

WARS1 ATP13A1 FAM91A1 ARHGAP39 HM13 BCR NT5DC3 WDR47 CACNG3 STAU2 CLTC PKM UQCRC2 GABRA5

7.51e-0511391271436417873
Pubmed

Histocompatibility genes of mice. VII. H-13, a new histocompatibility locus in the fifth linkage group.

HM13 PAX1

7.90e-05412725340356
Pubmed

Deletion of alpha-neurexins does not cause a major impairment of axonal pathfinding or synapse formation.

NRXN3 OR10A4

7.90e-054127217347997
Pubmed

The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing.

TRPC3 TRPC5

7.90e-054127226520460
Pubmed

Phenotyping structural abnormalities in mouse embryos using high-resolution episcopic microscopy.

MBTD1 KMT5B

7.90e-054127225256713
Pubmed

Coinheritance of BRCA1 and BRCA2 mutations with Fanconi anemia and Bloom syndrome mutations in Ashkenazi Jewish population: possible role in risk modification for cancer development.

BLM BRCA2

7.90e-054127215726604
Pubmed

The associations between single nucleotide polymorphisms of DNA repair genes, DNA damage, and age-related cataract: Jiangsu Eye Study.

WRN BLM

7.90e-054127223322570
Pubmed

Timeless Maintains Genomic Stability and Suppresses Sister Chromatid Exchange during Unperturbed DNA Replication.

BLM BRCA2

7.90e-054127219112184
Pubmed

A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2.

BLM BRCA2

7.90e-054127222789542
Pubmed

Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases.

WRN BLM

7.90e-054127212181313
Pubmed

The interaction site of Flap Endonuclease-1 with WRN helicase suggests a coordination of WRN and PCNA.

WRN BLM

7.90e-054127216326861
Pubmed

TRPC1- and TRPC3-dependent Ca2+ signaling in mouse cortical astrocytes affects injury-evoked astrogliosis in vivo.

TRPC3 TRPC5

7.90e-054127228636132
Pubmed

Mapping the expression of transient receptor potential channels across murine placental development.

TRPM6 TRPC3 TRPC5

9.10e-0524127333884443
Pubmed

Genetic mapping of mouse transient receptor potential (Trrp) genes responsible for capacitative calcium entry channels to chromosomes 3, 7, 9, and X.

TRPC3 TRPC5 PKM

9.10e-052412739722956
Pubmed

International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.

TRPM6 TRPC3 TRPC5

1.03e-0425127316382100
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

KEAP1 BCR CTTNBP2NL MAST4 STAU2 AKAP11

1.24e-04209127636779422
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

GTPBP4 WARS1 POLR1A GART CLIC4 ANKHD1 TRRAP POLR3A WDR47 BLM CLTC PKM PDCD11 UQCRC2 DYNC1I2

1.29e-0413531271529467282
Pubmed

An introduction to TRP channels.

TRPM6 TRPC3 TRPC5

1.30e-0427127316460286
Pubmed

Formation of novel TRPC channels by complex subunit interactions in embryonic brain.

TRPC3 TRPC5

1.31e-045127212857742
Pubmed

Enhanced capacitative calcium entry and TRPC channel gene expression in human LES smooth muscle.

TRPC3 TRPC5

1.31e-045127212736151
Pubmed

Expression of a novel homeobox gene Ehox in trophoblast stem cells and pharyngeal pouch endoderm.

CLTC PAX1

1.31e-045127214648851
Pubmed

Multiplicity of chromosome 2 histocompatibility genes: new loci, H-44 and H-45.

HM13 EPB42

1.31e-04512723301647
Pubmed

RecQ helicase expression in patients with telomeropathies.

WRN BLM

1.31e-045127238874681
Pubmed

RecQ helicases: suppressors of tumorigenesis and premature aging.

WRN BLM

1.31e-045127212803543
Pubmed

Store-operated Ca2+ entry and Ca2+ responses to hypothalamic releasing hormones in anterior pituitary cells from Orai1-/- and heptaTRPC knockout mice.

TRPC3 TRPC5

1.31e-045127230452936
Pubmed

Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases.

WRN BLM

1.31e-045127215965237
Pubmed

Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity.

WRN BLM

1.31e-045127218978339
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

RPGRIP1L WRN MUC16 RNF213 FAM91A1 BLM ZBED6 VANGL1 CLTC PKM ATP6V0A2

1.37e-047771271135844135
Pubmed

Human Regulatory Protein Ki-1/57 Is a Target of SUMOylation and Affects PML Nuclear Body Formation.

GTPBP4 GTPBP1 POLR3A EMG1 MRPL38

1.37e-04134127528695742
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

GTPBP4 WARS1 POLR1A GART ANKHD1 TRRAP BLM CLTC PDCD11 UQCRC2

1.49e-046531271022586326
Pubmed

Calcium Channels Formed by Mammalian Trp Homologues.

TRPC3 TRPC5

1.97e-046127211390792
Pubmed

trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry.

TRPC3 TRPC5

1.97e-04612728646775
Pubmed

Polymorphisms in genes involved in DNA double-strand break repair pathway and susceptibility to benzene-induced hematotoxicity.

WRN BRCA2

1.97e-046127216728435
Pubmed

Linear correlation between the number of olfactory sensory neurons expressing a given mouse odorant receptor gene and the total volume of the corresponding glomeruli in the olfactory bulb.

OR6A2 OR10A4

1.97e-046127226100963
Pubmed

Zfp423/OAZ mutation reveals the importance of Olf/EBF transcription activity in olfactory neuronal maturation.

ZNF423 OR10A4

1.97e-046127223035080
Pubmed

TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations.

TRPC3 TRPC5

1.97e-046127232414784
GeneFamilyRecQ like helicases

WRN BLM

2.76e-0459621049
GeneFamilyTransient receptor potential cation channels

TRPM6 TRPC3 TRPC5

4.32e-0428963249
ToppCellTracheal-NucSeq-Epithelial-Epi_submucosal-gland|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SH3RF1 FOLH1 ENPP3 RAP1GAP2 MUC16 AACS LIMCH1 DOP1B

1.13e-0720012780eb9ad8c0373bcc62029ec21c590ed03aaacd039
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RAB31 WARS1 COL27A1 RHOBTB3 ZEB2 LIMCH1 ALDH1A3

1.70e-061991277bdedcc7c8f3be0996200c882dda82fb2658655c0
ToppCellTracheal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Mucous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SH3RF1 FOLH1 ENPP3 RAP1GAP2 MUC16 SEMA3E DOP1B

1.76e-062001277c450a15e21fa72d071ed6e3b9f22de557a0f3cea
ToppCellBronchial-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Mucous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FOLH1 ENPP3 MUC16 AACS SEMA3E DOP1B CA8

1.76e-062001277ed093626a9cac7531a2bf02f6e345c5e84b8c060
ToppCellBronchial-NucSeq-Epithelial-Epi_submucosal-gland|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FOLH1 ENPP3 MUC16 PLEKHH1 AACS DOP1B CA8

1.76e-06200127785c0f038bcfb42669dca2b80273b0f8a1421405e
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Myeloid-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELPLG ADAM19 ITGAE KMO RYR1 ATP6V0A2

1.23e-051781276ee674e379ee57e40eb2560ff5ed4c13d8db7ed9d
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Myeloid|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELPLG ADAM19 ITGAE KMO RYR1 ATP6V0A2

1.23e-0517812766c45bf197d6c1be0ef7d3a644c0062acf1e24e4d
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Myeloid-macrophage|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELPLG ADAM19 ITGAE KMO RYR1 ATP6V0A2

1.23e-051781276cd85dcefe94ee742db64b63e105e13532321894a
ToppCellPND28-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

EEFSEC SQLE ITGAE RYR1 BLM KNL1

1.27e-0517912769dea57494d59abd6e8abf34e31faf53462ea0fa0
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SH3BP2 DGKB MUC16 MED13L ZEB2 FAM186A

1.57e-05186127623b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCellHematolymphoid-Endothelial-NOSTRIN|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

ZNF423 CLIC4 BCR SOX13 MAST4 EPAS1

2.37e-052001276032df80aa5c40991e1c1e80f9d8da106e6aeaee2
ToppCellHematolymphoid-Endothelial-NOSTRIN---|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

ZNF423 CLIC4 BCR SOX13 MAST4 EPAS1

2.37e-05200127668fce28690246895fd33354b30960ebcc31aa4cc
ToppCellTracheal-NucSeq-Epithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SH3RF1 ENPP3 MUC16 AACS LIMCH1 DOP1B

2.37e-052001276d3af0a706baf66e3f32e67b17dcfc31e5b32ce0e
ToppCellHematolymphoid-Endothelial-NOSTRIN-|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

ZNF423 CLIC4 BCR SOX13 MAST4 EPAS1

2.37e-052001276376b19ab5a7cd2c85f726d8ba41337d4525863e5
ToppCellHematolymphoid-Endothelial-NOSTRIN--|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

ZNF423 CLIC4 BCR SOX13 MAST4 EPAS1

2.37e-0520012767fa54370221ed61bac0e09e6bcf1f3dff202a846
ToppCellHematolymphoid-Endothelial-NOSTRIN----L2-6|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

ZNF423 CLIC4 BCR SOX13 MAST4 EPAS1

2.37e-052001276878bbbe32e3602723aa14ef32877ab2453b8c6e5
ToppCellHematolymphoid-Endothelial|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

ZNF423 CLIC4 BCR SOX13 MAST4 EPAS1

2.37e-0520012767136936d05ab344a560cf159684c881063b5430d
ToppCellSubstantia_nigra-Macroglia-OLIGODENDROCYTE-O2-Tfr-Oligodendrocyte.Tfr.Ndrg2_(Ndrg2)-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

CRYBG2 STPG4 FAM186A GP1BA

2.98e-05621274f7697057fb5568368ec7edead2bcdd25ede7627b
ToppCellSubstantia_nigra-Macroglia-OLIGODENDROCYTE-O2-Tfr-Oligodendrocyte.Tfr.Ndrg2_(Ndrg2)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

CRYBG2 STPG4 FAM186A GP1BA

2.98e-0562127419867e62ca7e024572192a2654e2eb8f226bdd60
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic-Mast_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ENPP3 USP29 TRIM54 ZEB2 ATP6V0A2

7.29e-051511275f5ae450e3daa10540ca8437d05efe2d86ac70960
ToppCellTransverse-Dendritic_cell-cDC1|Dendritic_cell / Region, Cell class and subclass

SELPLG DUSP18 CTTNBP2NL PLCD1 ATP6V0A2

7.29e-0515112756870f3b5d2bfad849c3203658b5f28f0ae181295
ToppCellCV-Healthy-3|Healthy / Virus stimulation, Condition and Cluster

GART VANGL1 STAU2 EPAS1 KNL1

8.00e-05154127526bf81a86700db7e65c2384ffe94ed4253ea4047
ToppCellFLU-Healthy-1|Healthy / Virus stimulation, Condition and Cluster

RAB31 RNF213 PXYLP1 KIR3DL1 KNL1

9.30e-05159127597c8e16a7ac10ebba96daee97f9fb1d4a404f23b
ToppCellFLU-Healthy-1|FLU / Virus stimulation, Condition and Cluster

RAB31 RNF213 PXYLP1 KIR3DL1 KNL1

9.30e-051591275fe2a9f79b058e89214256e736f6e266830cdfa28
ToppCellCV-Mild-3|Mild / Virus stimulation, Condition and Cluster

TRPC3 BCR KMT5B POLN KNL1

1.14e-0416612755599f90fc0e15a3670b03187085eba91228390a2
ToppCelldroplet-Heart-nan-24m-Hematologic-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BLM PLEKHH1 BRCA2 ARHGAP28 POLN

1.17e-041671275bad33497ceeab968a7eb8a48b921c6f936390743
ToppCell5'-Adult-LymphNode-Hematopoietic-Plasma_cells-IgG_plasma_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAM19 EML6 RNF213 MED13L HM13

1.20e-041681275f5a18123f84c62211d9279e9c41e90122e4c4895
ToppCellfacs-Skin-Skin_Anagen-18m-Lymphocytic-T_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM6 SELPLG COL27A1 ITGAE KIR3DL1

1.24e-041691275630d921aa8fb5681d06a4e09b833855c374be484
ToppCellfacs-Skin-Skin_Anagen-18m-Lymphocytic-nan|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM6 SELPLG COL27A1 ITGAE KIR3DL1

1.24e-041691275468284d4a3a0557aed04eadb1aba2317babc6904
ToppCellfacs-Skin-Skin_Anagen-18m-Lymphocytic|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM6 SELPLG COL27A1 ITGAE KIR3DL1

1.24e-0416912756f765e142d127545e622fe24b5287cd6e9706ccc
ToppCell10x5'v1-week_17-19-Myeloid_DC-DC-DC1|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

SELPLG DUSP18 CTTNBP2NL STPG4 PLCD1

1.24e-041691275488ba50631a64cb9e0d69219491c66ac824c9e7d
ToppCellcontrol-Myeloid-Eosinophils|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

ENPP3 SOX13 OR6K3 EPAS1 CA8

1.31e-04171127582f736c33ed96c0865618e8f8eb82a5487126bdc
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_VISp_Penk_Col27a1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

DUSP18 COL27A1 DGKB SEMA3E GABRA5

1.31e-041711275d07e2c5f7d7f12c68860d4161d76372de174f1d8
ToppCelldroplet-Lung-LUNG-30m-Myeloid-Myeloid_Dendritic_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM19 POLR1A ITGAE KMO RYR1

1.34e-041721275a5344760b10ecdc0101f78b93b8fc0f8107068c5
ToppCell367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

ATP13A1 MED13L TRRAP MRPL38 LIMCH1

1.34e-041721275da959c1abadafd79b7a0088a25eb8ef8efa3a0c2
ToppCell3'_v3-blood-Mast|blood / Manually curated celltypes from each tissue

TRPM6 ENPP3 KMO EPAS1 CA8

1.34e-041721275e7a46bbeff749ca59b9f1357409ce1ad59dd22dd
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

TRPM6 ADAM19 HIPK1 ERP27 GABRR3

1.46e-04175127506eace2e681980456299167b48bd49bcfea5e940
ToppCell5'-Adult-LymphNode-Hematopoietic-Plasma_cells|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAM19 EML6 RNF213 MED13L HM13

1.46e-0417512756a093c74a6f3daeff07759d6eec542fc5c709149
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ZNF423 DGKB NRXN3 LIMCH1 EPAS1

1.46e-041751275316f2ea930437bf1243b1c0f45e6bd864112c6f2
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ZNF423 DGKB NRXN3 LIMCH1 EPAS1

1.46e-041751275a9f08e1e4c2997dcdd3e5d92daac480da19100b8
ToppCellwk_15-18-Epithelial-Proximal_epithelial-Proximal_secretory_3|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

CRYBG2 MUC16 NT5DC3 NRXN3 ALDH1A3

1.50e-0417612758d9d0fb46c418b2067be58aec822e8c2b1561461
ToppCellfacs-Skin-nan-18m-Lymphocytic-T_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM6 SELPLG COL27A1 ITGAE KIR3DL1

1.54e-04177127517065d37fd41f04f67282bee00365daa185e8355
ToppCellCV-Severe-7|Severe / Virus stimulation, Condition and Cluster

ADAM19 TRPC3 RNF213 ZBED6 PDCD11

1.54e-04177127582fdd6185b368f54f03de389427cbe3071d21a99
ToppCellfacs-Skin-nan-18m-Lymphocytic-nan|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM6 SELPLG COL27A1 ITGAE KIR3DL1

1.54e-0417712756e45e1a5a894ca2e4ebc5cdb17fdf79e9e188185
ToppCellFetal_29-31_weeks-Epithelial-lung_goblet_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ENPP3 MUC16 NRXN3 PAX1 CA8

1.54e-041771275a4c001a8e44142babf9f24dfe6f7b73a70b11b16
ToppCellfacs-Skin-nan-18m-Lymphocytic|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM6 SELPLG COL27A1 ITGAE KIR3DL1

1.54e-0417712759ff3a77c5c62c8a950c46ca22cd7bde425b84c9a
ToppCellFetal_29-31_weeks-Epithelial-lung_goblet_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ENPP3 MUC16 NRXN3 PAX1 CA8

1.54e-041771275363e07b0f347f3716d530a28ead854b98e27d37c
ToppCell356C-Fibroblasts-Fibroblast-E-|356C / Donor, Lineage, Cell class and subclass (all cells)

FOLH1 ZNF423 CPS1 FAM186A ALDH1A3

1.58e-041781275a493a277d175e5e153410a745b26ebe2e0839ea0
ToppCelldroplet-Skin-nan-18m-Lymphocytic-nan|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM6 SELPLG COL27A1 ITGAE KIR3DL1

1.58e-04178127512d5c6be6cfbf733e3cb02780606b3725eda7d2b
ToppCell356C-Fibroblasts-Fibroblast-E|356C / Donor, Lineage, Cell class and subclass (all cells)

FOLH1 ZNF423 CPS1 FAM186A ALDH1A3

1.58e-041781275371218babddfd3d8a7bb82a46ce65327ee3fcf12
ToppCelldroplet-Skin-nan-18m-Lymphocytic-T_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM6 SELPLG COL27A1 ITGAE KIR3DL1

1.58e-041781275e0769ad06f92423a3cb6c78a61da3ba5bd9b4eae
ToppCelldroplet-Skin-nan-18m-Lymphocytic|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM6 SELPLG COL27A1 ITGAE KIR3DL1

1.58e-04178127511c2ce093b7538518c8d4497dc5b0b4da22bf1a8
ToppCell3'_v3-lymph-node_spleen-Hematopoietic_Erythro-Mega|lymph-node_spleen / Manually curated celltypes from each tissue

COL6A5 CAPN11 CER1 EPB42 GP1BA

1.62e-0417912754e0cf069bc47328eda753a4edc7e89b8915d52bb
ToppCellGlobus_pallidus-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendrocyte.Trf.Mbp_(Mbp)-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

FOLH1 PLEKHH1 FAM186A PAX1

1.65e-049612749673d03916705c675686bb4282dedd3dc5e98625
ToppCellGlobus_pallidus-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendrocyte.Trf.Mbp_(Mbp)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

FOLH1 PLEKHH1 FAM186A PAX1

1.65e-049612747e2810f5f5a17fcc7ae40edfd3e885740b575e29
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SH3RF1 FOLH1 COL27A1 COL6A5 LIMCH1

1.66e-04180127508ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)

RAB31 WARS1 CTTNBP2NL APIP EPAS1

1.66e-0418012752bc3fd2e4c249bf236340c5f0483747faa5c04ec
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Myeloid-Dendritic-conventional_dendritic_cell|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)

RAB31 WARS1 CTTNBP2NL APIP EPAS1

1.70e-0418112751b4eb044825ede6361928442524b1988c8ef58b3
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Myeloid-Dendritic|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)

RAB31 WARS1 CTTNBP2NL APIP EPAS1

1.70e-0418112758d7ebbedc373d55e29da02ac2728b4f4118038f2
ToppCellTCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-2|TCGA-Skin / Sample_Type by Project: Shred V9

DARS2 ADIPOR1 VANGL1 CLTC CA8

1.70e-0418112759d5b331cabc5524f0a9fd8b571e87be4c447c7d4
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM6 RHOBTB3 RAP1GAP2 LIMCH1 GP1BA

1.79e-0418312752e831a4d99c6f983793df71c0994124c943c6da9
ToppCellPBMC-Mild-cDC_9|Mild / Compartment, Disease Groups and Clusters

ADAM19 POLR1A RNF213 DARS2 ZBED6

1.84e-0418412752e0c9a2c40c892a2d435eafb31f1f838de9baf15
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Children_(3_yrs) / Lineage, Cell type, age group and donor

SH3RF1 MAST4 LIMCH1 HSD17B11 CA8

1.89e-04185127598b8ee42b89d97e4c9db01740e0c193503c68f2c
ToppCellCV-Moderate-7|Moderate / Virus stimulation, Condition and Cluster

ADAM19 RNF213 ZEB2 CLTC DOP1B

1.89e-041851275a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCellfacs-Lung-24m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_type_2|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SELPLG ADAM19 ITGAE KMO RYR1

1.89e-041851275ed7b26bdebfd0df2b4f5020a855a052d94ae7219
ToppCellLV-07._Pericyte|LV / Chamber and Cluster_Paper

SH3RF1 COL27A1 DGKB SOX13 ZEB2

1.89e-041851275acb38eba871ec72f2a8136a33b87d33b8c85465d
ToppCellRV-07._Pericyte|RV / Chamber and Cluster_Paper

SH3RF1 COL27A1 DGKB SOX13 EPAS1

1.93e-041861275c533b264fbe12bc35467486fc7fbde24ba968fe1
ToppCell10x5'-Lung-Mast|Lung / Manually curated celltypes from each tissue

ENPP3 RHOBTB3 SOX13 MAST4 ATP6V0A2

1.98e-041871275f8ac5ca5cbe9c6f3d8c0fffc20fe08ca1aea43c0
ToppCelldroplet-Skin-nan-21m-Lymphocytic-nan|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM6 SELPLG COL27A1 ITGAE KIR3DL1

1.98e-04187127538d7b19fde6811f5fbf548b2464486b197476dc6
ToppCellEpithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|World / Lineage, Cell type, age group and donor

SH3RF1 MAST4 LIMCH1 HSD17B11 CA8

1.98e-04187127581cc8435b2704a9a8287b3f54acaae0f11dd4ac7
ToppCell10x5'-Lung-Mast-Mast_cells|Lung / Manually curated celltypes from each tissue

ENPP3 RHOBTB3 SOX13 MAST4 ATP6V0A2

1.98e-041871275da275d2c774b3e6a8ed77f777dd0676ecf2ddd2c
ToppCellRV-07._Pericyte|World / Chamber and Cluster_Paper

SH3RF1 COL27A1 DGKB SOX13 EPAS1

1.98e-041871275dc274d6bbda619a2c914d84e2b4069cfef1739d1
ToppCellCOVID-19-Heart-EC_2|Heart / Disease (COVID-19 only), tissue and cell type

BCR SOX13 CTTNBP2NL MAST4 EPAS1

1.98e-04187127540ffc06a3e3251d9b12da390210d3e045af7537a
ToppCelldroplet-Skin-nan-21m-Lymphocytic|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM6 SELPLG COL27A1 ITGAE KIR3DL1

1.98e-041871275ea33a5bd60b7f5f6d5b07a7f06a5a56395943641
ToppCelldroplet-Skin-nan-21m-Lymphocytic-T_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM6 SELPLG COL27A1 ITGAE KIR3DL1

1.98e-0418712751dbc2c0ab85033e5de776bbfdb73ebd3a50d2cc6
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

HIPK1 RNF213 MED13L ZEB2 ZBED6

2.03e-041881275ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPC3 TRPC5 RAP1GAP2 NRXN3 CA8

2.03e-0418812751efbc99bcd6542e5d9fa91edb7c4295167914786
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_ILC|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SELPLG RAP1GAP2 RNF213 ZEB2 KIR3DL1

2.03e-0418812759abd78970bbe4ed03b59a83da63bbd334712f605
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SELPLG RAP1GAP2 RNF213 ZEB2 KIR3DL1

2.03e-041881275f7dc29dfec68236883469e848be5db34f5526d6b
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D175|Adult / Lineage, Cell type, age group and donor

WARS1 COL27A1 GART NRXN3 MAST4

2.03e-041881275ec38def1fdbb34ed9b30244806975bd5a4370164
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_ILC-NK_cell|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SELPLG RAP1GAP2 RNF213 ZEB2 KIR3DL1

2.03e-0418812755ae8ccdd328cf117da1d01ced2c3b7f763a5f1f1
ToppCellcontrol-Myeloid-CD14_Monocytes_2|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

WARS1 SQLE CLIC4 ZEB2 PKM

2.08e-0418912757f78b5bb8195f99b18082cbb612e9199b7a1538c
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

RAB31 CTTNBP2NL ZEB2 RYR1 CA8

2.14e-0419012752d54fca50593fbd11fe13fc2bfaf937a05db776d
ToppCellCOVID-19-kidney-Proliferating_T_cell|COVID-19 / Disease (COVID-19 only), tissue and cell type

UBASH3A BLM BRCA2 EPB42 KNL1

2.19e-041911275bae388e0e9447d576e68465d73d8313ef6925ffa
ToppCell5'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_arterial_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BCR CTTNBP2NL MAST4 LIMCH1 EPAS1

2.19e-041911275adb2e3efcad02889d8229325080da5e7830fd3ae
ToppCellRV-08._Macrophage|World / Chamber and Cluster_Paper

RAB31 RNF213 ZEB2 BRCA2 KNL1

2.24e-041921275a1b5dc5beb97a23729b97b54fb4574d10d8fbfb3
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CLIC4 NT5DC3 CLTC PKM ALDH1A3

2.35e-041941275f44394c8a6f86483063f2f5722f003a8a0a70254
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD8-Tem/emra_CD8|lymph-node_spleen / Manually curated celltypes from each tissue

SELPLG RAP1GAP2 SOX13 ZEB2 KIR3DL1

2.35e-041941275ecdfc27d06e363fb23f0309f26ef6404a89f14ec
ToppCellChildren_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

ZNF423 SOX13 CTTNBP2NL NRXN3 EPAS1

2.35e-04194127540842a7160f337bfc191ee15fbda3e3d38a04c57
ToppCellCOVID-19-kidney-Proliferating_T_cell|kidney / Disease (COVID-19 only), tissue and cell type

UBASH3A BLM BRCA2 EPB42 KNL1

2.41e-0419512757e05e56f8d0a7a052830c7db12b10dace7d10760
ToppCellControl-Myeloid-ncMonocyte|Control / Disease state, Lineage and Cell class

WARS1 RAP1GAP2 MED13L CTTNBP2NL BLM

2.41e-041951275fcb05948e7480dc53f06f3fc9b9c3fc129874edd
ToppCell3'-Pediatric_IBD-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CLIC4 SOX13 MAST4 LIMCH1 EPAS1

2.41e-041951275b0979c1b5e4576468b8fe4e9027650859e598b34
ToppCellCOVID-19_Mild-Classical_Monocyte-cMono_4|COVID-19_Mild / Disease condition and Cell class

SH3BP2 RNF213 FAM91A1 MED13L ZEB2

2.47e-0419612753729d1444c65cad640377894decc64129bc3fd5b
ToppCellIPF-Endothelial-VE_Capillary_B|Endothelial / Disease state, Lineage and Cell class

WARS1 SOX13 ZEB2 NRXN3 EPAS1

2.47e-0419612758f0f72ead06abe02b575e443552eacc2151077ef
ToppCell10x5'v1-week_14-16-Myeloid_neutrophil-granulo-eo/baso/mast-basophil|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

SELPLG ENPP3 EPAS1 ATP6V0A2 CA8

2.47e-0419612755bb8653af62334ded8aad48b24b64d7b54bc3cd5
ToppCell3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

WARS1 COL27A1 RHOBTB3 COL6A5 ALDH1A3

2.47e-04196127585507488f83d8f71b3ee2ad5e5aa0b6ad6193873
ToppCellCOPD-Endothelial-VE_Capillary_B|Endothelial / Disease state, Lineage and Cell class

WARS1 SH3RF1 NRXN3 MAST4 EPAS1

2.52e-04197127530dbc05ea66892d2e18ff375ffa86d1db7bc4083
ToppCellCOVID-19-Epithelial-Club,_Basal_cells|Epithelial / Condition, Lineage and Cell class

MUC16 RYR1 PLEKHH1 EPAS1 CA8

2.52e-04197127578ed2810e5a765327e7a6da0ca5d4854bf7a0b6f
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_dendritic|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

RAB31 SH3BP2 ZEB2 CLTC PKM

2.52e-041971275e2c53742c7d8d1b63d93843f82330b9e20f1faa6
ToppCellBronchial-NucSeq-Immune_Myeloid-Mast_cell-Mast_cell|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ENPP3 RAP1GAP2 SOX13 ZEB2 ATP6V0A2

2.52e-041971275bed8a9b73af5caee51b1232b31c24a59353658df
DrugPNU-0293363 [326823-19-2]; Up 200; 10uM; MCF7; HT_HG-U133A

CDK16 WARS1 RHOBTB3 SQLE GART BCR TRRAP DARS2 PLCD1 EPAS1

1.28e-07192127106573_UP
Disease1-palmitoylglycerophosphocholine measurement

TRPC3 EML6

5.16e-0531232EFO_0021089
DiseaseWerner syndrome (implicated_via_orthology)

WRN BLM

1.71e-0451232DOID:5688 (implicated_via_orthology)
DiseaseCerebellar Diseases

RPGRIP1L ZEB2

3.57e-0471232C0007760
DiseaseMeckel syndrome (implicated_via_orthology)

RPGRIP1L TBC1D32

4.75e-0481232DOID:0050778 (implicated_via_orthology)
Disease2R,3R-dihydroxybutyrate measurement

WARS1 CPS1

6.09e-0491232EFO_0800314
Diseasenicotine dependence (implicated_via_orthology)

TRPC3 TRPC5

1.11e-03121232DOID:0050742 (implicated_via_orthology)
DiseaseCongenital muscular dystrophy

POMT2 RYR1

1.11e-03121232cv:C0699743
Diseasetreatment-resistant hypertension

POLR1A ENPP3 EML6 AACS

1.14e-031091234EFO_1002006
Diseasehepcidin:transferrin saturation ratio

EML6 MUC16

1.75e-03151232EFO_0007902
Diseaseureidopropionic acid measurement

RPGRIP1L CPS1

1.99e-03161232EFO_0010542
Diseasemuscular dystrophy (is_implicated_in)

POMT2 CHKB

2.25e-03171232DOID:9884 (is_implicated_in)
Diseasecyclic adenosine monophosphate measurement

MAST4 PXYLP1

2.25e-03171232EFO_0010473
Diseaseserum hepcidin measurement

EML6 AKAP11

2.52e-03181232EFO_0004504
Diseasefacial asymmetry measurement

SLC39A9 NRXN3

2.81e-03191232EFO_0009751
Diseasebipolar disorder, body mass index

ADAM19 RPGRIP1L AACS

3.42e-03721233EFO_0004340, MONDO_0004985
Diseasehyperglycemia (biomarker_via_orthology)

ADIPOR1 EPAS1

3.44e-03211232DOID:4195 (biomarker_via_orthology)
Diseaseurinary metabolite measurement

FOLH1 CPS1 KMO AACS CA8

3.70e-032451235EFO_0005116
Diseasenon-small cell lung carcinoma

TRPC3 CPS1 BRCA2

3.84e-03751233EFO_0003060

Protein segments in the cluster

PeptideGeneStartEntry
HLAFCITNGMTPKAF

VANGL1

426

Q8TAA9
SFPAERTHGSNIAKM

CTTNBP2NL

316

Q9P2B4
HRPMSSIFFDAGSKA

EPAS1

601

Q99814
NTMCAKFQFTPTHVG

EPB42

646

P16452
PRHISVAMDKFGFSL

B4GALT1

266

P15291
HPESNTAGMDIFAKF

CLIC4

111

Q9Y696
KAELPLVFSAFHMSG

TBC1D32

1136

Q96NH3
FLKMASGHAFQPDLV

AACS

586

Q86V21
NKMSLHNLATVFGPT

BCR

1196

P11274
IMAAATGHPFPKVFN

ADAM19

371

Q9H013
AAVKGAPETLHSMFS

ATP13A1

651

Q9HD20
KTTVFGMTGHLPDFC

GTPBP1

261

O00178
QPYAFTTKSLFVGHM

GTPBP4

196

Q9BZE4
AFSDMPRAHSFTSKG

SH3BP2

216

P78314
ALETMDTGKPFLHAF

ALDH1A3

116

P47895
SKGFHTIPSTDISMF

CACNG3

251

O60359
TFSPSFHNQAIMVTK

AKAP11

741

Q9UKA4
FTFFLTMDPKNTGHI

CAPN11

711

Q9UMQ6
NFHTFVPSSKEMVAL

C7orf31

366

Q8N865
HFMFRKTPASQGVIL

CER1

136

O95813
PVLSAAIATKMAQFH

CHKB

161

Q9Y259
TTKAFLPAMTKNNHG

HSD17B11

151

Q8NBQ5
SPRAMFVSSKGHTFL

POLN

606

Q7Z5Q5
FMNIHPSGVKTESAV

NR2C1

241

P13056
KSMAASGNLGHTPFV

UQCRC2

436

P22695
DHNISPTIGASFMTK

RAB31

31

Q13636
RHAKNAVFSPSMFGS

ARHGAP39

876

Q9C0H5
AMGFLKTSPAGEAHS

MUC16

2516

Q8WXI7
PFSHLTSGFRKTNMS

MUC16

10161

Q8WXI7
KAFSTCAGHLMVFPI

OR6K3

251

Q8NGY3
FGSAIVTYMAPKSRH

OR2A14

251

Q96R47
PTMHFTIAEGFVKAT

ADIPOR1

281

Q96A54
HKVPSFQPFVGSSMF

MED13L

936

Q71F56
SFIAAPVTCFKHAPM

MBTD1

151

Q05BQ5
ITSNFKGPEHMQSLS

RPGRIP1L

756

Q68CZ1
TTKHSGFPVRMDNAV

HIPK1

666

Q86Z02
SGHNPFFGKLQMVTV

DOP1B

841

Q9Y3R5
PYLGFQTHKMNTSAF

KMT5B

91

Q4FZB7
SPNLKSHAVTMFEVG

FAM91A1

396

Q658Y4
PGFTGNFSTQKVKMH

FOLH1

331

Q04609
MSATFAKFHPNLVVG

DYNC1I2

336

Q13409
HKQSKAVAVTSMSFP

DYNC1I2

426

Q13409
FRHGFVAVLSKPSIM

ITGAE

961

P38570
IHDGVSKANFSIGPM

KIR3DL1

171

P43629
GGIFKAFSMLSAHVI

OR4F6

231

Q8NGB9
TSMHLFFQFKTTSPD

NRXN3

891

Q9Y4C0
PAGALSFNAFKTVMD

DECR2

121

Q9NUI1
MSKPHSEAGTAFIQT

PKM

1

P14618
KPLFSSGQFSMKNHD

KNL1

726

Q8NG31
SHFGFSQMPTSSVKD

GABRA5

26

P31644
ALSHTISPFMNKFFP

HM13

116

Q8TCT9
IFRMPSAEGKHQAFS

OR10A4

226

Q9H209
MSKNGDQHPSATLFV

PLCD1

736

P51178
AAAMTFKHPSREGSL

PAX1

416

P15863
VFHSMPEFGAAINKG

OSGIN2

281

Q9Y236
GIHTAFLKAMLSTGF

CPS1

1341

P31327
FPSTANKSMTFDHRL

GABRR3

121

A8MPY1
PAQPMISVKCSSFHF

KMO

281

O15229
TGNSMKELNFSHLPS

BLM

446

P54132
SPKETFNASFSGHMT

BRCA2

511

P51587
SAEDAMKHPFFLSLG

CDK16

436

Q00536
SMEAIFLAHGPSFKE

ENPP3

491

O14638
EFHLSTFKGRSPMLN

COL6A5

81

A8TX70
GSEHTVNFKAFPMEL

CA8

126

P35219
FHKVSLVSGAQMEAP

CRYBG2

36

Q8N1P7
SVSSHFVGFLMKNAP

SQLE

301

Q14534
SFSNKFPHSSPMVKS

DGKB

86

Q9Y6T7
SFLFGKMNPHAVQFE

COL27A1

196

Q8IZC6
PNFTLHMESITFSKT

GP1BA

361

P07359
HAAQMSAVSFVPLKA

MAST4

1746

O15021
HSMVQKFPGVSFGIS

ERP27

76

Q96DN0
AQFMAHKVVLASSSP

KEAP1

91

Q14145
ASSSPVFKAMFTNGL

KEAP1

101

Q14145
AKAHTGPVFTMYTTL

EML6

1591

Q6ZMW3
VSFMPGLHFQKSPIS

FAM186A

756

A6NE01
MEASFFKHPDLTTGQ

FAM216A

96

Q8WUB2
KAPAAFGLVSFLMHA

SLC39A9

186

Q9NUM3
SASFVPDHKASMVLF

RYR1

2491

P21817
APAHSLTKSQMFEGV

LIMCH1

581

Q9UPQ0
MHIPSAAGRYKAFST

OR6A2

231

O95222
AVSHVFMLLFNVKSP

RHOBTB3

276

O94955
IFFSSVTIPKMLANH

OR1A1

71

Q9P1Q5
FYGTALSMHLKPSAV

OR13F1

251

Q8NGS4
THSKAAVMATLLFPG

APIP

116

Q96GX9
HSTFFPALQGAQTKM

WARS1

336

P23381
FSVSSVTHKGIPMAA

SELPLG

286

Q14242
VIAFPKSFRGHDLMS

DARS2

601

Q6PI48
IMFHVSTKLPFTDGD

RAP1GAP2

331

Q684P5
TFPAMVHRTAGQKDS

POLR1A

226

O95602
ATFAVHFMVLSKSGP

POMT2

296

Q9UKY4
MAFLASGPYLTHQQK

NDUFB9

1

Q9Y6M9
HGKKMFLITNSPSSF

NT5DC3

291

Q86UY8
IGEPGTQMTLKTFHF

POLR3A

1041

O14802
FFHLIPVSTPKNGMS

PXYLP1

26

Q8TE99
LFHVSSMSVFPQGLK

WRN

111

Q14191
FHGTKYAAIDPSMVS

SPG21

276

Q9NZD8
TSMHTSKIGVFPGNY

SH3RF1

486

Q7Z6J0
HQPMASGFVDFSKGL

ANKHD1

2456

Q8IWZ3
SQPVKMFDRHSSLAG

CLTC

136

Q00610
KNLAFSPATMAHAFL

RNF213

4466

Q63HN8
MNFTVGFKPLLGDAH

TRIM54

1

Q9BYV2
PFGKIGTVSIFHMSD

PDCD11

1251

Q14690
ISDLGNKTSPMSHSF

WDR47

331

O94967
FPDMHNSSISKILGS

SOX13

446

Q9UN79
SGPFLMSVDHCFSIK

EEFSEC

221

P57772
SVHGGIQNFTMPSKF

TRPM6

141

Q9BX84
KHQETMTPAGLSFFQ

MRPL38

306

Q96DV4
ERGPAHSKMFSVQLS

STAU2

31

Q9NUL3
HIFPEGKVNMSSEFL

TAFAZZIN

146

Q16635
IFSAPAFPAAVSSMK

PSD2

626

Q9BQI7
SPTIAKMGQEHSLFF

STPG4

226

Q8N801
STVMAPNLFFSRSKH

ARHGAP28

536

Q9P2N2
SNHKFLDRMSPFGSL

THUMPD2

461

Q9BTF0
SSPQMHVGSAATKVF

USP29

406

Q9HBJ7
ASAAAVFSHFIMKFP

SLC9B1

196

Q4ZJI4
GMRKPSHSGFALFTD

PLEKHH1

1031

Q9ULM0
NHTALTVVMASKGYP

GART

331

P22102
HFPVGCMKVGTSFSI

EMG1

166

Q92979
VALGSKSFMFPSAVA

ZBED6

851

P86452
MSSIRAAFNGPYAHK

SEMA3E

346

O15041
GLLFSKFNGHMSEPS

TRPC5

846

Q9UL62
FHMQKLAGSSAASSP

ZNF423

1041

Q2M1K9
KVLMATHGFSGTSPF

ZEB2

401

O60315
DGRIKCMFFPHNTST

TIGD7

311

Q6NT04
TTDFDFSVPGSMKLH

TRRAP

3421

Q9Y4A5
KSTVIHMTVGGFLPF

TM9SF1

461

O15321
ILRSPFMKFVAHAAS

TRPC3

366

Q13507
MGFPVHTALKALAAT

UBASH3A

31

P57075
EFINMFLFPASKTSG

ATP6V0A2

626

Q9Y487
FQLFGKNTVHMVSSP

DUSP18

156

Q8NEJ0
DSSMDHFQKFLPTVG

MYOZ1

81

Q9NP98