Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	GABRG2 HTR6 MAS1 FFAR1 OR2G3 INSRR SEMA5A CASR GRIK2 LTB4R2 GRM1 GRM3 EDNRB CXCR5 ADRA1B ADRB1 BRS3 OR4A16 AGTR1 PLXNA2 CNR2 CXCR1 EPHA8	6.58e-05	1353	140	23	GO:0004888
GeneOntologyMolecularFunction	calcium ion binding	PADI4 CALB1 ANXA8L1 PCDHA13 DGKG PCDHA12 PCDHA8 PCDHA7 PCDHA6 CASR PCDHA4 ANXA8 PCDHA3 THBS3 ATP2C1 PCDH9	7.35e-05	749	140	16	GO:0005509
GeneOntologyMolecularFunction	G protein-coupled receptor activity	HTR6 MAS1 FFAR1 OR2G3 CASR LTB4R2 GRM1 GRM3 EDNRB CXCR5 ADRA1B ADRB1 BRS3 OR4A16 AGTR1 CNR2 CXCR1	1.55e-04	884	140	17	GO:0004930
GeneOntologyMolecularFunction	cyclin-dependent protein serine/threonine kinase activator activity	CCNY CCNYL1 CDK5R2	1.77e-04	16	140	3	GO:0061575
GeneOntologyMolecularFunction	angiotensin type II receptor activity	MAS1 AGTR1	2.90e-04	4	140	2	GO:0004945
GeneOntologyMolecularFunction	G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential	GRM1 ADRB1	4.81e-04	5	140	2	GO:0099530
GeneOntologyMolecularFunction	angiotensin receptor activity	MAS1 AGTR1	4.81e-04	5	140	2	GO:0001595
GeneOntologyMolecularFunction	neurotransmitter receptor activity	GABRG2 HTR6 GRIK2 GRM1 ADRB1	6.96e-04	100	140	5	GO:0030594
GeneOntologyMolecularFunction	glutamate receptor activity	GRIK2 GRM1 GRM3	8.72e-04	27	140	3	GO:0008066
GeneOntologyBiologicalProcess	homophilic cell adhesion via plasma membrane adhesion molecules	PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3 IGSF21 PCDH9	4.79e-06	187	138	9	GO:0007156
GeneOntologyBiologicalProcess	regulation of phospholipase A2 activity	ANXA8L1 ANXA8 AGTR1	3.40e-05	10	138	3	GO:0032429
GeneOntologyBiologicalProcess	cell-cell adhesion via plasma-membrane adhesion molecules	PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3 ATP2C1 IGSF21 PCDH9	5.00e-05	313	138	10	GO:0098742
Domain	Cadherin_tail	PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3	1.03e-08	37	141	7	PF15974
Domain	Cadherin_CBD	PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3	1.03e-08	37	141	7	IPR031904
Domain	Cadherin_2	PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3 PCDH9	3.03e-08	65	141	8	PF08266
Domain	Cadherin_N	PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3 PCDH9	3.03e-08	65	141	8	IPR013164
Domain	Cadherin_CS	PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3 PCDH9	1.73e-06	109	141	8	IPR020894
Domain	CADHERIN_1	PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3 PCDH9	2.27e-06	113	141	8	PS00232
Domain	Cadherin	PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3 PCDH9	2.27e-06	113	141	8	PF00028
Domain	CADHERIN_2	PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3 PCDH9	2.43e-06	114	141	8	PS50268
Domain	-	PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3 PCDH9	2.43e-06	114	141	8	2.60.40.60
Domain	CA	PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3 PCDH9	2.59e-06	115	141	8	SM00112
Domain	Cadherin-like	PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3 PCDH9	2.77e-06	116	141	8	IPR015919
Domain	Cadherin	PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3 PCDH9	3.14e-06	118	141	8	IPR002126
Domain	7TM_GPCR_Srsx	HTR6 EDNRB ADRA1B ADRB1 BRS3 AGTR1 CNR2	2.25e-05	112	141	7	SM01381
Domain	AnnexinVIII	ANXA8L1 ANXA8	5.66e-05	2	141	2	IPR009115
Domain	Cyclin_Y	CCNY CCNYL1	5.66e-05	2	141	2	IPR012399
Domain	NCD3G	CASR GRM1 GRM3	1.14e-04	13	141	3	PF07562
Domain	GPCR_3_9-Cys_dom	CASR GRM1 GRM3	1.14e-04	13	141	3	IPR011500
Domain	GPCR_3_CS	CASR GRM1 GRM3	1.44e-04	14	141	3	IPR017979
Domain	DUF4782	GRAMD1A GRAMD1B	1.69e-04	3	141	2	IPR031968
Domain	VAST	GRAMD1A GRAMD1B	1.69e-04	3	141	2	PS51778
Domain	DUF4782	GRAMD1A GRAMD1B	1.69e-04	3	141	2	PF16016
Domain	ANF_lig-bd_rcpt	CASR GRIK2 GRM1 GRM3	1.69e-04	37	141	4	IPR001828
Domain	ANF_receptor	CASR GRIK2 GRM1 GRM3	1.69e-04	37	141	4	PF01094
Domain	L_dom-like	NLRP12 INSRR FBXL12 TLR7 LRRC43 STK11IP NLRP14 CMIP LGI1 LRRC74B	1.97e-04	328	141	10	IPR032675
Domain	Peripla_BP_I	CASR GRIK2 GRM1 GRM3	2.09e-04	39	141	4	IPR028082
Domain	-	CCNY CCNYL1 BRF1 CDK5R2	2.30e-04	40	141	4	1.10.472.10
Domain	Cyclin-like	CCNY CCNYL1 BRF1 CDK5R2	3.06e-04	43	141	4	IPR013763
Domain	PXA	SNX19 SNX13	3.36e-04	4	141	2	SM00313
Domain	PXA	SNX19 SNX13	3.36e-04	4	141	2	PS51207
Domain	PXA	SNX19 SNX13	3.36e-04	4	141	2	PF02194
Domain	Sorting_nexin_C	SNX19 SNX13	3.36e-04	4	141	2	IPR013937
Domain	Phox_assoc	SNX19 SNX13	3.36e-04	4	141	2	IPR003114
Domain	Nexin_C	SNX19 SNX13	3.36e-04	4	141	2	PF08628
Domain	GPCR_3	CASR GRM1 GRM3	5.07e-04	21	141	3	IPR000337
Domain	GPCR_Rhodpsn_7TM	HTR6 MAS1 FFAR1 OR2G3 LTB4R2 EDNRB CXCR5 ADRA1B ADRB1 BRS3 OR4A16 AGTR1 CNR2 CXCR1	5.55e-04	670	141	14	IPR017452
Domain	ATII_rcpt	CXCR5 AGTR1	5.58e-04	5	141	2	IPR000248
Domain	7tm_3	CASR GRM1 GRM3	5.84e-04	22	141	3	PF00003
Domain	G_PROTEIN_RECEP_F3_2	CASR GRM1 GRM3	5.84e-04	22	141	3	PS00980
Domain	G_PROTEIN_RECEP_F3_3	CASR GRM1 GRM3	5.84e-04	22	141	3	PS00981
Domain	G_PROTEIN_RECEP_F3_1	CASR GRM1 GRM3	5.84e-04	22	141	3	PS00979
Domain	G_PROTEIN_RECEP_F3_4	CASR GRM1 GRM3	5.84e-04	22	141	3	PS50259
Domain	GPCR_3_C	CASR GRM1 GRM3	5.84e-04	22	141	3	IPR017978
Domain	7tm_1	HTR6 MAS1 FFAR1 OR2G3 LTB4R2 EDNRB CXCR5 ADRA1B ADRB1 BRS3 OR4A16 AGTR1 CNR2 CXCR1	6.14e-04	677	141	14	PF00001
Domain	G_PROTEIN_RECEP_F1_1	HTR6 MAS1 FFAR1 OR2G3 LTB4R2 EDNRB CXCR5 ADRA1B ADRB1 BRS3 OR4A16 AGTR1 CNR2 CXCR1	6.89e-04	685	141	14	PS00237
Domain	G_PROTEIN_RECEP_F1_2	HTR6 MAS1 FFAR1 OR2G3 LTB4R2 EDNRB CXCR5 ADRA1B ADRB1 BRS3 OR4A16 AGTR1 CNR2 CXCR1	7.50e-04	691	141	14	PS50262
Domain	-	NLRP12 FBXL12 TLR7 LRRC43 STK11IP NLRP14 CMIP LGI1 LRRC74B	7.53e-04	321	141	9	3.80.10.10
Domain	GPCR_Rhodpsn	HTR6 MAS1 FFAR1 OR2G3 LTB4R2 EDNRB CXCR5 ADRA1B ADRB1 BRS3 OR4A16 AGTR1 CNR2 CXCR1	7.60e-04	692	141	14	IPR000276
Domain	CXCR4/ACKR2	AGTR1 CXCR1	1.16e-03	7	141	2	IPR001277
Domain	EAR	DCTPP1 LGI1	1.16e-03	7	141	2	IPR009039
Domain	EAR	DCTPP1 LGI1	1.16e-03	7	141	2	PS50912
Domain	GPCR_3_mtglu_rcpt	GRM1 GRM3	1.54e-03	8	141	2	IPR000162
Domain	Semap_dom	SEMA5A SEMA4G PLXNA2	1.62e-03	31	141	3	IPR001627
Domain	SEMA	SEMA5A SEMA4G PLXNA2	1.62e-03	31	141	3	PS51004
Domain	Sema	SEMA5A SEMA4G PLXNA2	1.62e-03	31	141	3	SM00630
Domain	Sema	SEMA5A SEMA4G PLXNA2	1.62e-03	31	141	3	PF01403
Domain	Plexin_repeat	SEMA5A SEMA4G PLXNA2	1.78e-03	32	141	3	IPR002165
Domain	PSI	SEMA5A SEMA4G PLXNA2	1.78e-03	32	141	3	PF01437
Domain	DNA/RNA_helicase_DEAH_CS	DHX57 ERCC6L2 DHX29	2.31e-03	35	141	3	IPR002464
Domain	ADR_fam	ADRA1B ADRB1	2.45e-03	10	141	2	IPR002233
Domain	CYCLIN	CCNY CCNYL1 BRF1	2.93e-03	38	141	3	SM00385
Domain	DEAH_ATP_HELICASE	DHX57 ERCC6L2 DHX29	2.93e-03	38	141	3	PS00690
Domain	ANX	ANXA8L1 ANXA8	4.18e-03	13	141	2	SM00335
Domain	Annexin_repeat_CS	ANXA8L1 ANXA8	4.18e-03	13	141	2	IPR018252
Domain	Annexin	ANXA8L1 ANXA8	4.18e-03	13	141	2	PF00191
Domain	Annexin_repeat	ANXA8L1 ANXA8	4.18e-03	13	141	2	IPR018502
Domain	ANNEXIN	ANXA8L1 ANXA8	4.18e-03	13	141	2	PS00223
Domain	-	ANXA8L1 ANXA8	4.18e-03	13	141	2	1.10.220.10
Domain	PSI	SEMA5A SEMA4G PLXNA2	4.45e-03	44	141	3	IPR016201
Domain	Leu-rich_rpt	NLRP12 TLR7 LRRC43 STK11IP NLRP14 LGI1 LRRC74B	4.56e-03	271	141	7	IPR001611
Domain	Annexin	ANXA8L1 ANXA8	4.85e-03	14	141	2	IPR001464
Domain	PSI	SEMA5A SEMA4G PLXNA2	5.04e-03	46	141	3	SM00423
Domain	GRAM	GRAMD1A GRAMD1B	6.34e-03	16	141	2	SM00568
Domain	DUF1605	DHX57 DHX29	7.15e-03	17	141	2	IPR011709
Domain	Translation_prot_SH3-like	EIF5A2 SNX19	7.15e-03	17	141	2	IPR008991
Domain	OB_NTP_bind	DHX57 DHX29	7.15e-03	17	141	2	PF07717
Pathway	WP_GPCRS_NONODORANT	HTR6 MAS1 FFAR1 CASR LTB4R2 GRM1 GRM3 EDNRB CXCR5 ADRA1B ADRB1 AGTR1 CNR2 CXCR1	3.10e-09	266	96	14	MM15843
Pathway	KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	GABRG2 HTR6 MAS1 GRIK2 LTB4R2 GRM1 GRM3 EDNRB ADRA1B ADRB1 BRS3 AGTR1 CNR2	3.74e-08	272	96	13	M13380
Pathway	REACTOME_GPCR_LIGAND_BINDING	HTR6 FFAR1 CASR XK LTB4R2 GRM1 GRM3 EDNRB CXCR5 ADRA1B ADRB1 BRS3 AGTR1 CNR2 CXCR1	1.97e-07	430	96	15	MM15160
Pathway	REACTOME_SIGNALING_BY_GPCR	ABR HTR6 FFAR1 DGKG CASR NBEA XK LTB4R2 GRM1 GRM3 RGS3 EDNRB CXCR5 ADRA1B ADRB1 BRS3 AGTR1 CNR2 CXCR1	2.10e-07	702	96	19	M746
Pathway	REACTOME_SIGNALING_BY_GPCR	ABR HTR6 FFAR1 DGKG CASR XK LTB4R2 GRM1 GRM3 RGS3 EDNRB CXCR5 ADRA1B ADRB1 BRS3 AGTR1 CNR2 CXCR1	3.01e-07	646	96	18	MM14962
Pathway	REACTOME_GPCR_LIGAND_BINDING	HTR6 FFAR1 CASR XK LTB4R2 GRM1 GRM3 EDNRB CXCR5 ADRA1B ADRB1 BRS3 AGTR1 CNR2 CXCR1	5.07e-07	463	96	15	M507
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	HTR6 MAS1 FFAR1 EDNRB CXCR5 ADRA1B ADRB1 BRS3 AGTR1 CNR2 CXCR1	1.50e-06	260	96	11	M39397
Pathway	REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS	FFAR1 DGKG CASR LTB4R2 GRM1 RGS3 EDNRB ADRA1B BRS3 AGTR1	1.61e-06	210	96	10	MM15043
Pathway	REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS	FFAR1 DGKG CASR LTB4R2 GRM1 RGS3 EDNRB ADRA1B BRS3 AGTR1	2.16e-06	217	96	10	M18437
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	HTR6 FFAR1 XK LTB4R2 EDNRB CXCR5 ADRA1B ADRB1 BRS3 AGTR1 CNR2 CXCR1	2.38e-06	330	96	12	M18334
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	HTR6 FFAR1 XK LTB4R2 EDNRB CXCR5 ADRA1B ADRB1 BRS3 AGTR1 CNR2 CXCR1	2.61e-06	333	96	12	MM14963
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	HTR6 MAS1 EDNRB CXCR5 ADRA1B ADRB1 BRS3 AGTR1 CNR2	4.82e-06	186	96	9	MM15994
Pathway	KEGG_MEDICUS_REFERENCE_GPCR_PLCB_ITPR_SIGNALING_PATHWAY	LTB4R2 GRM1 EDNRB ADRA1B AGTR1	2.19e-05	50	96	5	M47951
Pathway	WP_GPCRS_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE	CASR GRM1 GRM3	1.31e-04	15	96	3	M39442
Pathway	WP_GPCRS_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE	CASR GRM1 GRM3	1.31e-04	15	96	3	MM15845
Pathway	WP_PEPTIDE_GPCRS	EDNRB CXCR5 BRS3 AGTR1 CXCR1	1.56e-04	75	96	5	M39696
Pathway	KEGG_CALCIUM_SIGNALING_PATHWAY	HTR6 LTB4R2 GRM1 EDNRB ADRA1B ADRB1 AGTR1	2.11e-04	178	96	7	M2890
Pathway	WP_SARSCOV2_AND_ACE2_RECEPTOR_MOLECULAR_MECHANISMS	MAS1 AGTR1	9.43e-04	7	96	2	M39867
Pathway	WP_MONOAMINE_GPCRS	HTR6 ADRA1B ADRB1	1.20e-03	31	96	3	MM15871
Pathway	WP_GPCRS_PEPTIDE	EDNRB CXCR5 BRS3 AGTR1	1.31e-03	70	96	4	MM15959
Pathway	WP_PROSTAGLANDIN_SYNTHESIS_AND_REGULATION	ANXA8L1 ANXA8 EDNRB	1.32e-03	32	96	3	MM15850
Pathway	WP_MONOAMINE_GPCRS	HTR6 ADRA1B ADRB1	1.44e-03	33	96	3	M39585
Pathway	REACTOME_ADRENOCEPTORS	ADRA1B ADRB1	1.60e-03	9	96	2	M27302
Pathway	REACTOME_ADRENOCEPTORS	ADRA1B ADRB1	1.60e-03	9	96	2	MM15009
Pubmed	Monoallelic yet combinatorial expression of variable exons of the protocadherin-alpha gene cluster in single neurons.	PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3	1.02e-13	15	142	7	15640798
Pubmed	Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice.	PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3	3.06e-13	17	142	7	29911975
Pubmed	CNR/Pcdhalpha family in subplate neurons, and developing cortical connectivity.	PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3	4.99e-13	18	142	7	15570159
Pubmed	Genomic organization of the family of CNR cadherin genes in mice and humans.	PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3	4.99e-13	18	142	7	10662547
Pubmed	Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex.	PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4	1.89e-12	11	142	6	9655502
Pubmed	Proteins of the CNR family are multiple receptors for Reelin.	PCDHA13 PCDHA8 PCDHA7 PCDHA6 PCDHA4 CNR2	3.77e-12	12	142	6	10612399
Pubmed	Developmental epigenetic modification regulates stochastic expression of clustered protocadherin genes, generating single neuron diversity.	PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3	5.32e-12	24	142	7	24698270
Pubmed	Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha.	PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3	1.80e-11	28	142	7	15347688
Pubmed	The DNA sequence and comparative analysis of human chromosome 5.	PCDHA13 PCDHA12 PCDHA8 PCDHA7 SEMA5A PCDHA6 PCDHA4 ATP10B PCDHA3	2.44e-11	75	142	9	15372022
Pubmed	CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons.	PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3 LHX6	1.02e-10	58	142	8	30377227
Pubmed	Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.	PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3 PCDH9	7.60e-10	74	142	8	10817752
Pubmed	Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.	PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3 PCDH9	1.05e-09	77	142	8	10835267
Pubmed	Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.	PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3 PCDH9	1.43e-09	80	142	8	10716726
Pubmed	Clustered gamma-protocadherins regulate cortical interneuron programmed cell death.	PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3	3.63e-09	57	142	7	32633719
Pubmed	Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.	PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3	1.28e-08	68	142	7	11230163
Pubmed	A striking organization of a large family of human neural cadherin-like cell adhesion genes.	PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3	1.92e-08	72	142	7	10380929
Pubmed	A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220.	PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3 AP4M1	3.39e-08	119	142	8	28625976
Pubmed	Dissociation of heterotrimeric g proteins in cells.	HTR6 CASR EDNRB CXCR5 ADRA1B AGTR1 CNR2 CXCR1	7.85e-07	179	142	8	18577758
Pubmed	A microarray minisequencing system for pharmacogenetic profiling of antihypertensive drug response.	CASR EDNRB ADRB1 AGTR1	3.15e-06	25	142	4	12544508
Pubmed	The repertoire of olfactory C family G protein-coupled receptors in zebrafish: candidate chemosensory receptors for amino acids.	CASR GRM1 GRM3	7.83e-06	10	142	3	17156446
Pubmed	Signaling complex formation of phospholipase Cbeta4 with metabotropic glutamate receptor type 1alpha and 1,4,5-trisphosphate receptor at the perisynapse and endoplasmic reticulum in the mouse brain.	CALB1 GRM1 GRM3	7.83e-06	10	142	3	15579147
Pubmed	Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.	PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3	1.54e-05	193	142	7	22589738
Pubmed	TaqI polymorphisms at the annexin VIII locus (ANX8).	ANXA8L1 ANXA8	1.66e-05	2	142	2	1364010
Pubmed	Cooperative binding promotes demand-driven recruitment of AnxA8 to cholesterol-containing membranes.	ANXA8L1 ANXA8	1.66e-05	2	142	2	29306076
Pubmed	Bone matrix regulates osteoclast differentiation and annexin A8 gene expression.	ANXA8L1 ANXA8	1.66e-05	2	142	2	21344395
Pubmed	Annexin A8 is up-regulated during mouse mammary gland involution and predicts poor survival in breast cancer.	ANXA8L1 ANXA8	1.66e-05	2	142	2	16203777
Pubmed	Increased expression of vascular endothelin type B and angiotensin type 1 receptors in patients with ischemic heart disease.	EDNRB AGTR1	1.66e-05	2	142	2	19706169
Pubmed	Heterodimerization of calcium sensing receptors with metabotropic glutamate receptors in neurons.	CASR GRM1	1.66e-05	2	142	2	11489900
Pubmed	Impact of angiotensin II type 1 and G-protein-coupled Mas receptor expression on the pulmonary performance of patients with idiopathic pulmonary fibrosis.	MAS1 AGTR1	1.66e-05	2	142	2	32777324
Pubmed	Control of adipogenesis by the autocrine interplays between angiotensin 1-7/Mas receptor and angiotensin II/AT1 receptor signaling pathways.	MAS1 AGTR1	1.66e-05	2	142	2	23592774
Pubmed	Annexins: from structure to function.	ANXA8L1 ANXA8	1.66e-05	2	142	2	11917092
Pubmed	Calbindin regulates Kv4.1 trafficking and excitability in dentate granule cells via CaMKII-dependent phosphorylation.	CALB1 KCND1	1.66e-05	2	142	2	34234278
Pubmed	Signal-binding specificity of the mu4 subunit of the adaptor protein complex AP-4.	LAMP2 AP4M1	1.66e-05	2	142	2	11139587
Pubmed	Expression of metabotropic glutamate receptor mRNAs in the human spinal cord: implications for selective vulnerability of spinal motor neurons in amyotrophic lateral sclerosis.	GRM1 GRM3	1.66e-05	2	142	2	11535235
Pubmed	Genetic deletion of the angiotensin-(1-7) receptor Mas leads to glomerular hyperfiltration and microalbuminuria.	MAS1 AGTR1	1.66e-05	2	142	2	19262461
Pubmed	Structure and function of Semaphorin-5A glycosaminoglycan interactions.	SEMA5A PLXNA2	1.66e-05	2	142	2	38548715
Pubmed	Annexin A8 controls leukocyte recruitment to activated endothelial cells via cell surface delivery of CD63.	ANXA8L1 ANXA8	1.66e-05	2	142	2	24769558
Pubmed	Increased expression of endothelin ET(B) and angiotensin AT(1) receptors in peripheral resistance arteries of patients with suspected acute coronary syndrome.	EDNRB AGTR1	1.66e-05	2	142	2	20108069
Pubmed	Short-term hypoxia upregulated Mas receptor expression to repress the AT1 R signaling pathway and attenuate Ang II-induced cardiomyocyte apoptosis.	MAS1 AGTR1	1.66e-05	2	142	2	29052864
Pubmed	Annexins: linking Ca2+ signalling to membrane dynamics.	ANXA8L1 ANXA8	1.66e-05	2	142	2	15928709
Pubmed	Intron-less processed Pcdhalpha genes in the central nervous system.	PCDHA8 PCDHA6	1.66e-05	2	142	2	14697259
Pubmed	VWF-mediated leukocyte recruitment with chromatin decondensation by PAD4 increases myocardial ischemia/reperfusion injury in mice.	PADI4 VWF	1.66e-05	2	142	2	24200682
Pubmed	A novel form of low-frequency hippocampal mossy fiber plasticity induced by bimodal mGlu1 receptor signaling.	GRIK2 GRM1	1.66e-05	2	142	2	22114260
Pubmed	The extracellular calcium-sensing receptor regulates human fetal lung development via CFTR.	CFTR CASR	1.66e-05	2	142	2	26911344
Pubmed	Annexin A8 identifies a subpopulation of transiently quiescent c-kit positive luminal progenitor cells of the ductal mammary epithelium.	ANXA8L1 ANXA8	1.66e-05	2	142	2	25803307
Pubmed	Aster Proteins Regulate the Accessible Cholesterol Pool in the Plasma Membrane.	GRAMD1A GRAMD1B	1.66e-05	2	142	2	32719109
Pubmed	Differential gene expression in migrating cortical interneurons during mouse forebrain development.	CALB1 DGKG LHX6	1.85e-05	13	142	3	20151419
Pubmed	Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.	HTR6 CASR ADRA1B ADRB1 AGTR1 CNR2 CXCR1	1.93e-05	200	142	7	18240029
Pubmed	Dynamic spatiotemporal gene expression in embryonic mouse thalamus.	SEMA5A GRM1 GRM3 EPHA8	2.40e-05	41	142	4	21192082
Pubmed	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	GABRG2 HTR6 NBEA GRIK2 GRM3 ADRA1B ADRB1 AGTR1	3.45e-05	300	142	8	19086053
Pubmed	The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics.	ADRA1B ADRB1 AGTR1	3.59e-05	16	142	3	15824464
Pubmed	Stable association between G alpha(q) and phospholipase C beta 1 in living cells.	CASR LTB4R2 EDNRB ADRA1B AGTR1	4.56e-05	95	142	5	16754659
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	IST1 HEATR5A SNX19 SNX13 GRAMD1B PLEKHM2 CAMSAP2 PLXNA2 DOP1B	4.79e-05	407	142	9	12693553
Pubmed	Possible involvement of angiotensin-converting enzyme 2 and Mas activation in inhibitory effects of angiotensin II Type 1 receptor blockade on vascular remodeling.	MAS1 AGTR1	4.95e-05	3	142	2	22665126
Pubmed	Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses in unipolar brush cells.	GRM1 GRM3	4.95e-05	3	142	2	34620856
Pubmed	Specific expression of annexin A8 in adult murine stratified epithelia.	ANXA8L1 ANXA8	4.95e-05	3	142	2	17082908
Pubmed	Human cerebrovascular contractile receptors are upregulated via a B-Raf/MEK/ERK-sensitive signaling pathway.	EDNRB AGTR1	4.95e-05	3	142	2	21223556
Pubmed	Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin Y and is essential for spermatogenesis.	CCNY CCNYL1	4.95e-05	3	142	2	22184064
Pubmed	Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of Gq/G11 by MAS.	MAS1 AGTR1	4.95e-05	3	142	2	16611642
Pubmed	Angiotensin II type 2 receptor promotes apoptosis and inhibits angiogenesis in bladder cancer.	MAS1 AGTR1	4.95e-05	3	142	2	28599664
Pubmed	CCNYL1, but Not CCNY, Cooperates with CDK16 to Regulate Spermatogenesis in Mouse.	CCNY CCNYL1	4.95e-05	3	142	2	26305884
Pubmed	Circadian-related heteromerization of adrenergic and dopamine D₄ receptors modulates melatonin synthesis and release in the pineal gland.	ADRA1B ADRB1	4.95e-05	3	142	2	22723743
Pubmed	Structural basis for different phosphoinositide specificities of the PX domains of sorting nexins regulating G-protein signaling.	SNX19 SNX13	4.95e-05	3	142	2	25148684
Pubmed	mGluR1 interacts with cystic fibrosis transmembrane conductance regulator and modulates the secretion of IL-10 in cystic fibrosis peripheral lymphocytes.	CFTR GRM1	4.95e-05	3	142	2	22520513
Pubmed	Molecular mechanisms of calcium-sensing receptor-mediated calcium signaling in the modulation of epithelial ion transport and bicarbonate secretion.	CFTR CASR	4.95e-05	3	142	2	25331955
Pubmed	Vascular anticoagulant beta: a novel human Ca2+/phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. Its molecular cloning, expression and comparison with VAC-alpha.	ANXA8L1 ANXA8	4.95e-05	3	142	2	2530088
Pubmed	Regulation of vascular angiotensin II type 1 and type 2 receptor and angiotensin-(1-7)/MasR signaling in normal and hypertensive pregnancy.	MAS1 AGTR1	4.95e-05	3	142	2	38061417
Pubmed	Genetic deletion of angiotensin AT2 receptor leads to increased cell numbers in different brain structures of mice.	MAS1 AGTR1	4.95e-05	3	142	2	11384784
Pubmed	RNA Sensing by Gut Piezo1 Is Essential for Systemic Serotonin Synthesis.	PIEZO1 TLR7	4.95e-05	3	142	2	32640190
Pubmed	The Ang-(1-7)/Mas-1 axis attenuates the expression and signalling of TGF-β1 induced by AngII in mouse skeletal muscle.	MAS1 AGTR1	4.95e-05	3	142	2	24588264
Pubmed	Two alpha1-adrenergic receptor subtypes regulating the vasopressor response have differential roles in blood pressure regulation.	ADRA1B ADRB1	4.95e-05	3	142	2	15598970
Pubmed	Disrupted-in-Schizophrenia 1 (DISC1) is necessary for the correct migration of cortical interneurons.	CALB1 LHX6	4.95e-05	3	142	2	22238109
Pubmed	A novel metabotropic glutamate receptor expressed in the retina and olfactory bulb.	GRM1 GRM3	4.95e-05	3	142	2	7722646
Pubmed	Angiotensin-(1-7) Suppresses Hepatocellular Carcinoma Growth and Angiogenesis via Complex Interactions of Angiotensin II Type 1 Receptor, Angiotensin II Type 2 Receptor and Mas Receptor.	MAS1 AGTR1	4.95e-05	3	142	2	26225830
Pubmed	Devil and angel in the renin-angiotensin system: ACE-angiotensin II-AT1 receptor axis vs. ACE2-angiotensin-(1-7)-Mas receptor axis.	MAS1 AGTR1	4.95e-05	3	142	2	19461648
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	ABR PCDHA12 PCDHA8 PCDHA7 PCDHA6 NBEA PCDHA3 URB1	6.59e-05	329	142	8	17474147
Pubmed	Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.	CALB1 SEMA5A SEMA4G EDNRB ZFHX2 PLXNA2 HOMEZ	8.15e-05	251	142	7	29031500
Pubmed	A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP).	GRM1 ADRB1 AGTR1	8.40e-05	21	142	3	15452121
Pubmed	Class 5 transmembrane semaphorins control selective Mammalian retinal lamination and function.	CALB1 SEMA5A PLXNA2	8.40e-05	21	142	3	21835343
Pubmed	The DNA sequence and comparative analysis of human chromosome 10.	MTRNR2L7 ANXA8L1 VSIR SEMA4G CCNY PDZD8 NANOS1 LGI1	9.16e-05	345	142	8	15164054
Pubmed	Neuroendocrinology of the lung revealed by single-cell RNA sequencing.	CALB1 AGTR1	9.88e-05	4	142	2	36469459
Pubmed	Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system.	GRM1 GRM3	9.88e-05	4	142	2	29079293
Pubmed	Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseases.	UNC13D TLR7	9.88e-05	4	142	2	19120489
Pubmed	TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells.	TLR7 PLEKHM2	9.88e-05	4	142	2	29150602
Pubmed	Endothelial nitric oxide synthase interactions with G-protein-coupled receptors.	EDNRB AGTR1	9.88e-05	4	142	2	10510297
Pubmed	Sex chromosome complement involvement in angiotensin receptor sexual dimorphism.	MAS1 AGTR1	9.88e-05	4	142	2	28254489
Pubmed	Adrenergic Receptors in Individual Ventricular Myocytes: The Beta-1 and Alpha-1B Are in All Cells, the Alpha-1A Is in a Subpopulation, and the Beta-2 and Beta-3 Are Mostly Absent.	ADRA1B ADRB1	9.88e-05	4	142	2	28219977
Pubmed	MRP4 and CFTR in the regulation of cAMP and β-adrenergic contraction in cardiac myocytes.	CFTR ADRB1	9.88e-05	4	142	2	22381067
Pubmed	Variability within alpha- and beta-adrenoreceptor genes as a predictor of cardiovascular function at rest and in response to mental challenge.	ADRA1B ADRB1	9.88e-05	4	142	2	12023679
Pubmed	Glutamate can act as a signaling molecule in mouse preimplantation embryos†.	GRIK2 GRM1 GRM3	1.27e-04	24	142	3	35746896
Pubmed	Semaphorin heterodimerization in cis regulates membrane targeting and neocortical wiring.	SEMA5A SEMA4G PLXNA2	1.62e-04	26	142	3	39152101
Pubmed	G protein-coupled receptors directly bind filamin A with high affinity and promote filamin phosphorylation.	MAS1 AGTR1	1.64e-04	5	142	2	26460884
Pubmed	Semaphorin 5A inhibits synaptogenesis in early postnatal- and adult-born hippocampal dentate granule cells.	SEMA5A PLXNA2	1.64e-04	5	142	2	25313870
Pubmed	Single nucleotide polymorphisms in genes of circulatory homeostasis in surviving pediatric intensive care patients with meningococcal infection.	ADRB1 AGTR1	1.64e-04	5	142	2	18679149
Pubmed	A dual role of EphB1/ephrin-B3 reverse signaling on migrating striatal and cortical neurons originating in the preoptic area: should I stay or go away?	CALB1 LHX6	1.64e-04	5	142	2	25100946
Pubmed	Pax6-/- mice have a cell nonautonomous defect in nonradial interneuron migration.	CALB1 LHX6	1.64e-04	5	142	2	17634386
Pubmed	Common deletion variants causing protocadherin-α deficiency contribute to the complex genetics of BAV and left-sided congenital heart disease.	PCDHA12 PCDHA7	1.64e-04	5	142	2	34888534
Pubmed	Chromosomal organization of adrenergic receptor genes.	ADRA1B ADRB1	1.64e-04	5	142	2	2154750
Pubmed	Quantitative genetic analysis of ventral midbrain and liver iron in BXD recombinant inbred mice.	GABRG2 ADRA1B	1.64e-04	5	142	2	14744041
Pubmed	Essential Roles of Cyclin Y-Like 1 and Cyclin Y in Dividing Wnt-Responsive Mammary Stem/Progenitor Cells.	CCNY CCNYL1	1.64e-04	5	142	2	27203244
Interaction	PCDHA10 interactions	PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3	8.55e-11	22	136	7	int:PCDHA10
Interaction	PCDHA8 interactions	PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3	8.45e-08	55	136	7	int:PCDHA8
Interaction	FLT3 interactions	GRWD1 PCDHA13 PCDHA12 RNF213 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3 URB1 AP4M1 VPS51 DOP1B	2.50e-07	318	136	13	int:FLT3
Interaction	PCDHA7 interactions	PCDHA12 PCDHA8 PCDHA7 PCDHA4	1.88e-06	14	136	4	int:PCDHA7
Interaction	NPTN interactions	TNFAIP8L2 MMS22L PLEKHG4 INTS1 FBXL12 RNF213 AGTR1 VPS51 DOP1B SYMPK	1.96e-05	278	136	10	int:NPTN
Interaction	PCDHA6 interactions	PCDHA8 PCDHA6 PCDHA3	2.45e-05	9	136	3	int:PCDHA6
Interaction	PCDHA1 interactions	PCDHA8 PCDHA4 PCDHA3	2.45e-05	9	136	3	int:PCDHA1
Interaction	C19orf38 interactions	CFTR RNF213 CCNY YIF1A CCNYL1 PRMT9	2.55e-05	86	136	6	int:C19orf38
Interaction	PCDHA4 interactions	PCDHA12 PCDHA8 PCDHA7 PCDHA4 IGSF21	5.27e-05	60	136	5	int:PCDHA4
Cytoband	5q31	PCDHA13 PCDHA12 CXCL14 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3	3.07e-09	115	142	8	5q31
Cytoband	Ensembl 112 genes in cytogenetic band chr5q31	PCDHA13 PCDHA12 CXCL14 PCDHA8 PCDHA7 PCDHA6 TMCO6 PCDHA4 PCDHA3	4.26e-07	298	142	9	chr5q31
Cytoband	1q21-q23	ADAMTS4 INSRR	7.25e-04	13	142	2	1q21-q23
GeneFamily	Clustered protocadherins	PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3	7.54e-08	64	103	7	20
GeneFamily	CD molecules\|C-X-C motif chemokine receptors	CXCR5 CXCR1	4.75e-04	6	103	2	1094
GeneFamily	Glutamate metabotropic receptors\|Protein phosphatase 1 regulatory subunits	GRM1 GRM3	8.80e-04	8	103	2	281
GeneFamily	Adrenoceptors	ADRA1B ADRB1	1.13e-03	9	103	2	169
GeneFamily	Annexins\|Endogenous ligands	ANXA8L1 ANXA8	2.41e-03	13	103	2	404
GeneFamily	WD repeat domain containing\|GRAM domain containing\|BEACH domain containing	GRAMD1A GRAMD1B	2.41e-03	13	103	2	1146
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZFHX2 HOMEZ	3.22e-03	15	103	2	529
GeneFamily	DEAH-box helicases	DHX57 DHX29	3.66e-03	16	103	2	500
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HLCS PCDHA8 XK SEMA4G DHX29 CDK5R2 EDRF1	9.49e-07	163	142	7	132aece9c79499b4bb3c2bde68d3d7202e1d8772
ToppCell	wk_08-11-Hematologic-Myeloid-Myelocyte-like\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	TNFAIP8L2 PADI4 MMS22L BTNL8 AKNA SNX19 VSIR	3.24e-06	196	142	7	4b88c96b737a747422674ad99c073b28e6febc7c
ToppCell	E16.5-Immune-Immune_Myeloid-Granulocytic-Neutrophil-Neutrophil_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TNFAIP8L2 PADI4 DGKG EIF5A2 VSIR HOMEZ	9.80e-06	153	142	6	6a2a2379238133ce0ad714af130ffe02dd317247
ToppCell	E16.5-Immune-Immune_Myeloid-Granulocytic-Neutrophil\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TNFAIP8L2 PADI4 DGKG EIF5A2 VSIR HOMEZ	9.80e-06	153	142	6	faa442dd925b2b09919e93c492ccc3f19803ad24
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DGKG NBEA GRIK2 GRM3 AGTR1 PCDH9	1.22e-05	159	142	6	5ca96db4281abb5f646150ccf36adc66ab201c78
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HLCS PCDHA8 AGBL5 SEMA4G DHX29 CDK5R2	1.40e-05	163	142	6	953a7db7e90a913e81002d2141fbbd5f1fdf2197
ToppCell	Entopeduncular-Macroglia-POLYDENDROCYTE-P1\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	ADAMTS4 CASR ATP10B THBS3 ERICH6	1.57e-05	98	142	5	fca0baf13520c53edb6da2fe3eb152fbd44df5ed
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DGKG NBEA GRIK2 GRM3 AGTR1 PCDH9	1.78e-05	170	142	6	876b84740e15399bfff2b9c7f0b80fd759bbdb3f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DGKG NBEA GRIK2 GRM3 AGTR1 PCDH9	1.78e-05	170	142	6	1f8738acf439d893880db7e1fdc9b3615ca00c39
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-epithelial_cell_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HTR6 CFTR INTS1 SEMA5A LHX6 VARS1	1.97e-05	173	142	6	a5172dee859bf6c2eed46c48bd64dfef0ff9f28f
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-Lgr5-_amplifying_undifferentiated_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HTR6 CFTR INTS1 SEMA5A LHX6 VARS1	1.97e-05	173	142	6	639b5b0b33ce5aa0bc26363c059717012ddc14c0
ToppCell	AT1_cells-Donor_07\|World / lung cells shred on cell class, cell subclass, sample id	PADI4 PIEZO1 SEMA5A ANXA8 ADRB1 NANOS1	1.97e-05	173	142	6	b29816427428c7053017477f59b828bf1357f3b2
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MAS1 FNDC4 CXCL14 SEMA5A PCDHA4 EDNRB	2.03e-05	174	142	6	f90ca117b729436cf452e2ddcec26ba525c5c13b
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_B-Branch_B1_(eMN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PCDHA13 GRIK2 SHD ZFHX2 CDK5R2 DOP1B	2.03e-05	174	142	6	271c51d220842402975d97c86c9acfdbdf62a32c
ToppCell	droplet-Liver-Hepatocytes-21m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPPL3 AKNA HLCS EIF5A2 XK PLEKHM2	2.17e-05	176	142	6	8e89471f838ea81235256cc2470f1c12c9b75f8a
ToppCell	wk_08-11-Endothelial-Blood_vessel_endothelial-Late_cap\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	EGLN3 VWF BTNL8 LHX6 VSIR ADRB1	2.70e-05	183	142	6	3e69cc605f166a1f04e3d077935f7cfd806f1ffd
ToppCell	Thalamus-Macroglia-POLYDENDROCYTE-P1-P1_1\|Thalamus / BrainAtlas - Mouse McCarroll V32	ADAMTS4 CASR ATP10B THBS3 CTPS1	2.98e-05	112	142	5	67b4d2ecc437398c985e6543b82bb593cb164f7f
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	MMS22L RNF213 LAMP2 URB1 EDRF1 DOP1B	3.43e-05	191	142	6	9454f642c3621370fa23640b631301346b300950
ToppCell	Control-Lymphoid-pDC\|Lymphoid / Condition, Lineage and Cell class	EGLN3 NBEA TLR7 SHD GRAMD1B PCDH9	3.74e-05	194	142	6	5f95a5a35f73222dbe2ca52cc580f4774f641403
ToppCell	mild-Myeloid-Neutrophils_3\|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	NLRP12 PADI4 BTNL8 LAMP2 VSIR CXCR1	3.85e-05	195	142	6	a1cfed0092debcc003eff6a62508556b7664d5e1
ToppCell	Skin-Tubules\|Skin / Skin and Kidney Cells in Lupus Nephritis Patients.	CALB1 CASR GRM3 TMEM52B BRS3 LGI1	3.96e-05	196	142	6	12e21cc310a261407b46e034108e8c93ea16e045
ToppCell	(7)_Epithelial_cells-(7)_Epithelial-I_(AT1)\|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	PIEZO1 ANXA8L1 UNC13D SEMA5A ANXA8 VSIR	4.31e-05	199	142	6	5a002d49a8b84c158f7b4d7a3e78e6a937757bb7
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Macroglial-Astrocyte\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	RNF213 CXCL14 SEMA5A EDNRB YIF1A THBS3	4.43e-05	200	142	6	7c66953ff6d8f16f4decd23c85232990d2d8c6c4
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Undifferentiated_Pleomorphic_Sarcoma-7\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	ADAMTS4 INSRR RGS3 OR4A16 LRRC74B	5.45e-05	127	142	5	c4809d8502f460370f824719d69b13b400a2b202
Computational	Genes in the cancer module 146.	HTR6 EDNRB CXCR5 ADRA1B ADRB1 AGTR1	1.15e-04	102	81	6	MODULE_146
Drug	nebivolol	ADRA1B ADRB1 VPS51 NANOS1 EPHA8	4.53e-06	40	140	5	CID000071301
Drug	AC1Q3ZOL	GABRG2 CALB1 HTR6 CFTR HLCS GRIK2 GRM1 GRM3 NANOS1 CNR2	4.63e-06	258	140	10	CID000002376
Disease	1,5 anhydroglucitol measurement	PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3	5.42e-11	29	136	7	EFO_0008009
Disease	visceral adipose tissue measurement, body mass index	PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3	1.63e-07	87	136	7	EFO_0004340, EFO_0004765
Disease	neuroticism measurement, cognitive function measurement	MMS22L HTR6 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3 GRM3 WDPCP MED24 NANOS1 PCDH9	3.88e-07	566	136	14	EFO_0007660, EFO_0008354
Disease	neutrophil count, basophil count	PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3 RCBTB1 CXCR1	1.04e-06	224	136	9	EFO_0004833, EFO_0005090
Disease	post-traumatic stress disorder symptom measurement	PCDHA8 PCDHA7 PCDHA6 PCDHA4 NBEA PCDHA3	2.25e-06	82	136	6	EFO_0008535
Disease	Abnormality of refraction	SPPL3 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 NBEA PCDHA3 GRM3 RGS3 GRAMD1B RCBTB1 PCDH9	2.97e-06	673	136	14	HP_0000539
Disease	pulse pressure measurement	TDRD15 PCDHA13 PCDHA12 RNF213 PCDHA8 PCDHA7 UNC13D PCDHA6 PCDHA4 NBEA PCDHA3 HEATR5A SNX19 ADRA1B PLEKHM2 TTLL6 OSBPL7 FBXO32 HOMEZ	2.21e-05	1392	136	19	EFO_0005763
Disease	Alcoholic Intoxication, Chronic	GABRG2 VWF CFTR SEMA5A GRM1 GRM3 CNR2 EPHA8	3.60e-05	268	136	8	C0001973
Disease	hemK methyltransferase family member 2 measurement	NLRP12 SHD	6.31e-05	3	136	2	EFO_0021891
Disease	myocardial infarction (biomarker_via_orthology)	EGLN3 VWF CASR LAMP2 AGTR1 KDM6A	1.02e-04	160	136	6	DOID:5844 (biomarker_via_orthology)
Disease	neutrophil count	SPPL3 PCDHA13 DGKG PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3 VSIR SNX13 MED24 CMIP ADRB1 RCBTB1 PNPLA3 CXCR1	2.16e-04	1382	136	17	EFO_0004833
Disease	fructose-1,6-bisphosphatase 1 measurement	NLRP12 PNPLA3	3.13e-04	6	136	2	EFO_0801606
Disease	post-traumatic stress disorder	PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3 NANOS1	3.59e-04	202	136	6	EFO_0001358
Disease	Hereditary pancreatitis	CFTR CASR	4.36e-04	7	136	2	C0238339
Disease	asthma	ADAMTS4 SPPL3 MUC16 UNC13D CASR ATP10B HEATR5A GRM3 CXCR5 OSBPL7 SYMPK	7.39e-04	751	136	11	MONDO_0004979
Disease	renovascular hypertension (implicated_via_orthology)	ADRB1 AGTR1	7.43e-04	9	136	2	DOID:1591 (implicated_via_orthology)
Disease	depressive symptom measurement	VWF SPPL3 PCDHA6 PCDHA4 PCDHA3 WDPCP NANOS1 PCDH9	8.34e-04	426	136	8	EFO_0007006
Disease	mean platelet volume	VWF RTTN UNC13D CASR RGS3 SNX13 GRAMD1B CMIP BRF1 OR4A16 PNPLA3 ESPL1 HOMEZ	8.96e-04	1020	136	13	EFO_0004584
Disease	Mood Disorders	HTR6 GRIK2 GRM3 ADRA1B ADRB1	1.11e-03	168	136	5	C0525045
Disease	neurotic disorder	MMS22L GRM3 MED24 NANOS1	1.25e-03	101	136	4	EFO_0004257
Disease	triglyceride measurement, alcohol consumption measurement	TDRD15 MACROD1 SNX13 CMIP	1.25e-03	101	136	4	EFO_0004530, EFO_0007878
Disease	end stage renal disease (is_marker_for)	VWF CASR CXCR1	1.26e-03	46	136	3	DOID:783 (is_marker_for)
Disease	Thrombus	VWF MAS1 VKORC1	1.26e-03	46	136	3	C0087086
Disease	Hirschsprung's disease (implicated_via_orthology)	EDNRB MED24	1.35e-03	12	136	2	DOID:10487 (implicated_via_orthology)
Disease	Thrombosis	VWF MAS1 VKORC1	1.51e-03	49	136	3	C0040053
Disease	diglyceride measurement	ABR XK PNPLA3	1.70e-03	51	136	3	EFO_0010223
Disease	Congestive heart failure	VWF EDNRB ADRB1 AGTR1	1.71e-03	110	136	4	C0018802
Disease	Heart failure	VWF EDNRB ADRB1 AGTR1	1.71e-03	110	136	4	C0018801
Disease	Left-Sided Heart Failure	VWF EDNRB ADRB1 AGTR1	1.71e-03	110	136	4	C0023212
Disease	Heart Failure, Right-Sided	VWF EDNRB ADRB1 AGTR1	1.71e-03	110	136	4	C0235527
Disease	Heart Decompensation	VWF EDNRB ADRB1 AGTR1	1.71e-03	110	136	4	C1961112
Disease	Myocardial Failure	VWF EDNRB ADRB1 AGTR1	1.71e-03	110	136	4	C1959583
Disease	vital capacity	MMS22L PIEZO1 POLR2B PCDHA13 PCDHA12 PCDHA8 PCDHA7 UNC13D PCDHA6 PCDHA4 PCDHA3 SNX13 CMIP CCNYL1	1.74e-03	1236	136	14	EFO_0004312
Disease	von Willebrand factor measurement, coronary artery disease	TDRD15 VWF MAS1 SEMA5A	2.21e-03	118	136	4	EFO_0001645, EFO_0004629
Disease	cholesterol:total lipids ratio, intermediate density lipoprotein measurement	TDRD15 SNX13 CMIP PNPLA3	2.42e-03	121	136	4	EFO_0008595, EFO_0020943
Disease	low density lipoprotein particle size measurement	TDRD15 MACROD1 PNPLA3	2.46e-03	58	136	3	EFO_0008593
Disease	pursuit maintenance gain measurement	FBXL12 GRIK2 CMIP PLXNA2	2.57e-03	123	136	4	EFO_0008433
Disease	Pancreatitis	CFTR CASR CNR2	2.58e-03	59	136	3	C0030305
Disease	cholesterol to total lipids in chylomicrons and extremely large VLDL percentage	TDRD15 PNPLA3	2.74e-03	17	136	2	EFO_0022232
Disease	response to opioid	MUC16 ADRB1 PCDH9	2.84e-03	61	136	3	EFO_0008541
Disease	HDL cholesterol change measurement, physical activity	MACROD1 SNX13 CMIP	2.97e-03	62	136	3	EFO_0003940, EFO_0007805
Disease	lymphocyte count	MMS22L PIEZO1 INSRR SPPL3 MACROD1 PCDHA6 VSIR GRAMD1B CMIP ADRB1 OSBPL7 ERCC6L2 PPIP5K2 VARS1 CNR2	3.14e-03	1464	136	15	EFO_0004587
Disease	Eczema	SPPL3 ATP10B LRRC43 WDPCP CXCR5 OSBPL7	3.22e-03	310	136	6	HP_0000964
Disease	cholangiocarcinoma (is_marker_for)	MUC16 ANXA8 OSBPL7	3.25e-03	64	136	3	DOID:4947 (is_marker_for)
Disease	type 1 diabetes mellitus (biomarker_via_orthology)	VWF ADRB1	3.43e-03	19	136	2	DOID:9744 (biomarker_via_orthology)
Disease	common carotid intimal medial thickness	TDRD15 MMS22L ERCC6L2	3.70e-03	67	136	3	EFO_0004860
Disease	neoplasm of mature B-cells	CXCR5 GRAMD1B	3.79e-03	20	136	2	EFO_0000096
Disease	unipolar depression	EGLN3 SPPL3 DGKG RNF213 UNC13D PCDHA6 PCDHA4 PCDHA3 GRIK2 WDPCP CXCR5 NANOS1 PCDH9	3.87e-03	1206	136	13	EFO_0003761
Disease	myeloid white cell count	PIEZO1 GRAMD1A SPPL3 DGKG VSIR SNX13 CMIP ADRB1 RCBTB1 PNPLA3 CXCR1	4.16e-03	937	136	11	EFO_0007988
Disease	COVID-19 (is_implicated_in)	TLR7 AGTR1	4.18e-03	21	136	2	DOID:0080600 (is_implicated_in)
Disease	activities of daily living score measurement	GRIK2 NANOS1	4.18e-03	21	136	2	EFO_0008451
Disease	Alzheimer disease, gastroesophageal reflux disease	MMS22L PCDHA4 PCDHA3 GRM3 SYMPK	4.18e-03	228	136	5	EFO_0003948, MONDO_0004975
Disease	dilated cardiomyopathy (biomarker_via_orthology)	MAS1 AGTR1	4.59e-03	22	136	2	DOID:12930 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
EIELEGSQSLRILCY	ABR	556	Q12979
LCYSLDGLRVDLLTI	AGBL5	196	Q8NDL9
IETLCVIALDRYLAI	ADRB1	146	P08588
LRYVSGDDLLLLASL	ERICH6	586	Q7L0X2
SASILNLCLISLDRY	HTR6	111	P50406
ELDALSRIQDLLGCY	PRMT9	76	Q6P2P2
DCYLRIQSISVLGLE	PRMT9	461	Q6P2P2
ERSIAIYLGIGLCLL	CFTR	116	P13569
SSLLLACIAVDRYLA	CXCR5	136	P32302
QSLIYTLTCRFEGLL	BTNL8	426	Q6UX41
VFLLTCLSIDRYLAI	AGTR1	116	P30556
TNRELSYLLLFSLLC	CASR	646	P41180
LVKASGRELCYILLF	GRM3	606	Q14832
RTLGCYVEILKLLSD	CMIP	451	Q8IY22
ASILSLCAISIDRYI	ADRA1B	131	P35368
GITVLSLCALSIDRY	EDNRB	186	P24530
NRCELLSFLLVLDYI	EDNRB	356	P24530
AECAIVTLVYLERLL	CCNY	186	Q8ND76
ESTRLLYCTTGVLLR	DHX29	671	Q7Z478
LYCTTGVLLRKLQED	DHX29	676	Q7Z478
AECAIVTLVYLERLL	CCNYL1	206	Q8N7R7
LVFVYLLCRESLRGD	CDK5R2	236	Q13319
ISFLLSLIDRLVLYC	EGLN3	91	Q9H6Z9
SLIDRLVLYCGSRLG	EGLN3	96	Q9H6Z9
LDLLFLLGLTSSVCI	ATP2C1	876	P98194
LIVDYSCALQREILL	GRAMD1A	106	Q96CP6
LIVDYSCALQRDILL	GRAMD1B	111	Q3KR37
LDLYARDGLRTLCIA	ATP10B	826	O94823
ELLSRLATLLGDYCG	AP4M1	81	O00189
VGSLLLTAIDRYLCL	CNR2	121	P34972
FGCLLLLIREIDLSV	MTRNR2L7	6	P0CJ74
IGLLDLATSYCENRL	RCBTB1	441	Q8NDN9
ARTLLLSEELLLYEG	RGS3	566	P49796
LVLTLLLYTALRCSA	PCDHA6	711	Q9UN73
TSGYLERILVCLLQG	ANXA8	151	P13928
LVLTLLLYTALRCSA	PCDHA7	711	Q9UN72
ALLYLTGVEISLCAD	PADI4	106	Q9UM07
LLYSGCRLTLLRSEK	MUC16	12591	Q8WXI7
LLLEICSYLDARLVL	FBXW9	86	Q5XUX1
LVLTLLLYTALRCSA	PCDHA8	711	Q9Y5H6
LVLTLLLYTALRCSA	PCDHA3	711	Q9Y5H8
TACVLIFTGEYLLRL	KCND1	236	Q9NSA2
YLLTAISVERCLSVL	MAS1	121	P04201
LGDNRTELPLTLYLC	GRWD1	76	Q9BQ67
LRLLTSTCGYKEVRL	INTS1	351	Q8N201
EVLLFLSQYLTLCGD	EDRF1	736	Q3B7T1
TLLCDLISLSLNRYD	MMS22L	261	Q6ZRQ5
LLELLTYLCLSFLRS	DOP1B	1311	Q9Y3R5
LICIQDGYLSLLTET	EIF5A2	91	Q9GZV4
ALLGKAVRCYESLIL	KDM6A	71	O15550
YEVLREILTTLGLSC	HLCS	361	P50747
RYLGSALELRALELC	NANOS1	121	Q8WY41
LLIIDYSENRLLACG	PLXNA2	116	O75051
PLLELLCLDTYFIGL	OR4A16	181	Q8NH70
FYLLAALIACLRLDS	PCDH9	6	Q9HC56
TLLECSRLLIFGSYD	PDZD8	326	Q8NEN9
SLRLCTGNLYLLSRA	PNPLA3	211	Q9NST1
LVCLVLGAVRSYALE	LAMP2	16	P13473
SSCGLEILDRYLLKV	LHX6	71	Q9UPM6
VLLCYLLTLTGNSAL	OR2I1P	31	Q8NGU4
VLLVLLGLLYSSTSC	PRSS54	16	Q6PEW0
LLLLLALYTARVDGS	CXCL14	21	O95715
LVLTLLLYTALRCSA	PCDHA13	711	Q9Y5I0
LVLTLLLYTALRCSA	PCDHA4	711	Q9UN74
LKDVVCYLSLLETGR	DGKG	161	P49619
KLILGCEDSSLILYE	WDPCP	351	O95876
LLCRLQAFGETLLLE	ADAMTS4	81	O75173
DTYLLLSLTCDLLRS	ESPL1	851	Q14674
VCLLLAAILDLARGY	IGSF21	11	Q96ID5
SYLTPLLDRCLERLT	HEATR5A	476	Q86XA9
LLDLVYADLGTLSRL	HEATR5A	1436	Q86XA9
TSGYLERILVCLLQG	ANXA8L1	151	Q5VT79
SLVYALNLGCSDLLL	FFAR1	41	O14842
YLSPTVLLLVSCDLG	FNDC4	26	Q9H6D8
LLYCTTGVLLRRLEG	DHX57	641	Q6P158
QDIGACLAILSLRIY	EPHA8	186	P29322
GRVLYTLRLTIDAEC	GABRG2	176	P18507
LLLACISVDRYLAIV	CXCR1	126	P25024
KLYRTDLALILCAGD	CALB1	246	P05937
LEAEIYRLGSCLEEL	AKNA	641	Q7Z591
AELRSCYLSSLDLLL	MACROD1	241	Q9BQ69
LGEEATVLCVSRLRY	INSRR	856	P14616
ILELYCDLLLARFGL	IST1	71	P53990
VELLISLAEGYSSRC	ERMARD	416	Q5T6L9
SLADIALLCLRYGLQ	HOMEZ	81	Q8IX15
LSDVLIYLVALAARC	DCTPP1	96	Q9H773
YVLRGLLRTSLSACI	ELP4	286	Q96EB1
EIALTTYETLRLCLD	ERCC6L2	256	Q5T890
TYETLRLCLDELNSL	ERCC6L2	261	Q5T890
GYCIDLLRELSTILG	GRIK2	461	Q13002
SSRELCYIILAGIFL	GRM1	626	Q13255
IRELLQTLYTSLCTL	FBXO32	166	Q969P5
EILVLGGYLRLSRSC	PPP1R18	511	Q6NYC8
GALLALYLARLELCD	SLC22A31	196	A6NKX4
VVNLLLSAELYCRAG	CAMSAP2	71	Q08AD1
LGELVRDTLYLRSCR	LRRC74B	51	Q6ZQY2
YRGLTIDSLAQLCVL	LRRC43	266	Q8N309
LVLTLLLYTALRCSA	PCDHA12	711	Q9UN75
TLQRLCEELEYSSLL	OSBPL7	506	Q9BZF2
YLSCTSELDRLLSAL	PLEKHM2	951	Q8IWE5
LYISLALGSTECILL	OR2G3	101	Q8NGZ4
LLEYLSSLSRLLQSC	RTTN	1681	Q86VV8
RQTLYTCLDVGLRLL	VARS1	1046	P26640
LRGIYSQLETLICSR	STK11IP	126	Q8N1F8
EGFLRDLCEVLLYLL	SNX13	221	Q9Y5W8
ESLLSLCKEGSYLVR	SHD	251	Q96IW2
ISSSRGLLTCIIYAL	TDRD15	891	B5MCY1
YASVLLTGLLSLQRC	LTB4R2	106	Q9NPC1
RYLSVCERLNLALSL	NKX1-2	186	Q9UD57
SECSSQELIRLLLYL	PLEKHG4	221	Q58EX7
LSYLQRLEVLGCTLS	FBXL12	201	Q9NXK8
DCYIVSGSRDATLLL	NBEA	2736	Q8NFP9
TLRAVELLYSIFCLD	MED24	761	O75448
RYDRLLETCSIALVG	CTPS1	291	P17812
LRSTYCLLNGLTDRD	POLR2B	156	P30876
GDTLYELRCSLQLAE	NDUFAF5	191	Q5TEU4
TLETCKGLLRSILTY	URB1	2051	O60287
LSSSILGCLLTLLVY	SEMA5A	976	Q13591
ITSLAFGDLLLLLTC	BRS3	86	P32247
YSTSLCGLVLLVDNR	C12orf4	321	Q9NQ89
LGLCATALVSYLIRL	RNF213	4876	Q63HN8
LLSRLCLDYETATIS	VPS51	526	Q9UID3
LAGLLTECRDVLLEL	TNFAIP8L2	116	Q6P589
LLLGLYLATVRSDLS	YIF1A	186	O95070
IFYTLQLLLGCLRTR	VKORC1	86	Q9BQB6
SLELLLYHCSIGRSL	ZFHX2	731	Q9C0A1
LASSLLYVACLREGR	SEMA4G	691	Q9NTN9
YCSRLLDLVFLLDGS	VWF	1271	P04275
DVLLVLGRLVLSCFE	RLF	121	Q13129
LGRLVLSCFELLLSV	RLF	126	Q13129
LKVSCLLLSGLLIYD	SPPL3	186	Q8TCT6
LTLLDSGLYCCLVVE	VSIR	136	Q9H7M9
SALLYFILLSGTRCE	TMEM52B	11	Q4KMG9
IELCLYTLGNLIVES	TMCO6	166	Q96DC7
VLLTELSNCTVRLYG	TBCC	206	Q15814
IRTALLTAGDIYLLS	THBS3	46	P49746
LLYDTLVLINLESCD	TTLL6	381	Q8N841
LIYCLGDIILEFLDL	SNX19	951	Q92543
ISLDLYTCELDLTNL	TLR7	826	Q9NYK1
YVLGKTFLLLARELC	BRF1	161	Q92994
SGSLDKYEDCLIRLL	SYMPK	636	Q92797
LLSEAQRCLYRDVTL	ZNF587B	31	E7ETH6
AACLLRFSGLSLVYL	PIEZO1	21	Q92508
SLLSILRYGALCNES	PPIP5K2	831	O43314
ESADYCILGLDLRQL	LCMT2	151	O60294
GACLLLTVLDYDTLG	UNC13D	996	Q70J99
SLLSIVYGALRCNIL	XK	176	P51811
LLSEAQRCLYRDVTL	ZNF814	31	B7Z6K7
YFLCLLSALLLTEGK	LGI1	21	O95970
GRDGLCRLSTYLEEL	NLRP12	6	P59046
YLERLSLESCGLTEA	NLRP14	816	Q86W24