Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionactin binding

WASL WAS FMN1 CAMK2B WASF2 WASF3 RUSC1 FMN2 PPP1R18 DAAM2 AFDN FHOD3 MYO15A PALLD SHANK3 FMNL1 VASP CAP1

4.74e-124799118GO:0003779
GeneOntologyMolecularFunctioncytoskeletal protein binding

WASL WAS FMN1 CAMK2B WASF2 WASF3 RUSC1 FMN2 PPP1R18 DAAM2 AFDN FHOD3 MYO15A PALLD SHANK3 FMNL1 VASP ENKD1 CAP1

4.19e-0710999119GO:0008092
GeneOntologyMolecularFunctionprotein domain specific binding

ADRB1 WAS ATN1 ATXN2 FMN1 WASF2 ARHGAP17 AFDN IRS1 IRS2 HCN2 CNTROB SHANK3 VASP

4.01e-058759114GO:0019904
GeneOntologyMolecularFunctionSH3 domain binding

WAS FMN1 WASF2 ARHGAP17 SHANK3 VASP

4.91e-05143916GO:0017124
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF787 FOXO1 KLF16 ZBTB45 CUX2 ZNF219 IRX5 HOXD3 UNCX ZIC5 ATOH8 ZFHX2 SOX18 POU3F1 ZNF579 DBP NR1D1

1.93e-0414129117GO:0000981
GeneOntologyMolecularFunctionprotein kinase A regulatory subunit binding

WASF2 WASF3 ACBD3

1.96e-0425913GO:0034237
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

FOXO1 KLF16 ZBTB45 CUX2 ZNF219 IRX5 HOXD3 ZIC5 ATOH8 ZNF335 ZFHX2 SOX18 POU3F1 DBP NR1D1

4.75e-0412449115GO:0000978
GeneOntologyMolecularFunctionhistone H3K4 monomethyltransferase activity

SETD1A KMT2B

5.65e-048912GO:0140945
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

FOXO1 KLF16 ZBTB45 CUX2 ZNF219 IRX5 HOXD3 ZIC5 ATOH8 ZNF335 ZFHX2 SOX18 POU3F1 DBP NR1D1

5.94e-0412719115GO:0000987
GeneOntologyMolecularFunctionDNA-binding transcription repressor activity, RNA polymerase II-specific

FOXO1 KLF16 ZBTB45 CUX2 ZNF219 POU3F1 NR1D1

6.51e-04320917GO:0001227
GeneOntologyMolecularFunctionmicrotubule severing ATPase activity

FIGNL2 FIGN

7.24e-049912GO:0008568
GeneOntologyMolecularFunctionphosphatidylinositol 3-kinase activator activity

IRS1 IRS2

7.24e-049912GO:0141038
GeneOntologyMolecularFunctionDNA-binding transcription repressor activity

FOXO1 KLF16 ZBTB45 CUX2 ZNF219 POU3F1 NR1D1

7.26e-04326917GO:0001217
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

FOXO1 KLF16 ZBTB45 CUX2 ZNF219 IRX5 HOXD3 ZIC5 RBL2 ATOH8 ZNF335 ZFHX2 SOX18 POU3F1 DBP NR1D1

8.49e-0414599116GO:0000977
GeneOntologyMolecularFunctionhistone H3K4 trimethyltransferase activity

SETD1A KMT2B

9.03e-0410912GO:0140999
GeneOntologyMolecularFunctionphosphatidylinositol 3-kinase binding

PIK3R2 IRS1 IRS2

9.90e-0443913GO:0043548
GeneOntologyMolecularFunctionhistone H3 methyltransferase activity

SETD1A KMT2B KMT2E

1.06e-0344913GO:0140938
GeneOntologyMolecularFunctionprofilin binding

FMNL1 VASP

1.55e-0313912GO:0005522
GeneOntologyMolecularFunctionsignaling receptor complex adaptor activity

IRS1 IRS2 SHANK3

1.92e-0354913GO:0030159
GeneOntologyMolecularFunctionprotein-containing complex destabilizing activity

FIGNL2 FIGN

2.08e-0315912GO:0140776
GeneOntologyMolecularFunctionprotein kinase A binding

WASF2 WASF3 ACBD3

2.36e-0358913GO:0051018
GeneOntologyMolecularFunctionArp2/3 complex binding

WASF2 WASF3

2.36e-0316912GO:0071933
GeneOntologyMolecularFunctiontranscription coactivator activity

BCL9L CITED4 SRA1 ATN1 SMARCC2 KMT2E

2.63e-03303916GO:0003713
GeneOntologyMolecularFunctionphosphatidylinositol 3-kinase regulator activity

IRS1 IRS2

3.00e-0318912GO:0035014
GeneOntologyMolecularFunctiontransmembrane receptor protein tyrosine kinase adaptor activity

IRS1 IRS2

3.00e-0318912GO:0005068
GeneOntologyMolecularFunctionhistone H3K4 methyltransferase activity

SETD1A KMT2B

3.70e-0320912GO:0042800
GeneOntologyMolecularFunctiontranscription coregulator activity

BCL9L CITED4 SRA1 ATN1 SMARCC2 ZFPM1 KMT2E SF1

4.12e-03562918GO:0003712
GeneOntologyMolecularFunctionhistone methyltransferase activity

SETD1A KMT2B KMT2E

4.18e-0371913GO:0042054
GeneOntologyBiologicalProcessactin filament organization

WASL WAS FMN1 PIK3R2 WASF2 WASF3 FMN2 ARHGAP17 DAAM2 FHOD3 MYO15A SHANK3 VASP CAP1 ARAP1

7.15e-095099215GO:0007015
GeneOntologyBiologicalProcessactin cytoskeleton organization

WASL WAS FMN1 PIK3R2 WASF2 WASF3 FMN2 ARHGAP17 DAAM2 FHOD3 MYO15A PALLD SHANK3 FMNL1 VASP CAP1 ARAP1

8.35e-088039217GO:0030036
GeneOntologyBiologicalProcessactin filament-based process

WASL ADRB1 WAS FMN1 PIK3R2 WASF2 WASF3 FMN2 ARHGAP17 DAAM2 FHOD3 MYO15A PALLD SHANK3 FMNL1 VASP CAP1 ARAP1

9.44e-089129218GO:0030029
GeneOntologyBiologicalProcessregulation of actin filament-based process

ADRB1 WAS FMN1 PIK3R2 WASF2 WASF3 ARHGAP17 DAAM2 FHOD3 SHANK3 VASP ARAP1

5.66e-074389212GO:0032970
GeneOntologyBiologicalProcessregulation of actin filament organization

WAS FMN1 PIK3R2 WASF2 WASF3 DAAM2 FHOD3 SHANK3 VASP ARAP1

9.19e-073009210GO:0110053
GeneOntologyBiologicalProcessregulation of actin cytoskeleton organization

WAS FMN1 PIK3R2 WASF2 WASF3 ARHGAP17 DAAM2 FHOD3 SHANK3 VASP ARAP1

1.13e-063849211GO:0032956
GeneOntologyBiologicalProcessactin filament polymerization

WASL WAS FMN1 PIK3R2 WASF3 DAAM2 FHOD3 VASP

2.15e-06190928GO:0030041
GeneOntologyBiologicalProcesssupramolecular fiber organization

WASL WAS FMN1 PIK3R2 WASF2 WASF3 FMN2 ARHGAP17 DAAM2 FHOD3 MYO15A SELENON SHANK3 VASP CAP1 ARAP1

4.66e-069579216GO:0097435
GeneOntologyBiologicalProcessactin polymerization or depolymerization

WASL WAS FMN1 PIK3R2 WASF3 DAAM2 FHOD3 VASP

6.80e-06222928GO:0008154
GeneOntologyBiologicalProcessactin nucleation

WASL FMN1 WASF2 WASF3 FMN2

1.06e-0565925GO:0045010
GeneOntologyBiologicalProcessregulation of supramolecular fiber organization

WAS FMN1 PIK3R2 WASF2 WASF3 DAAM2 FHOD3 SHANK3 VASP ARAP1

2.57e-054389210GO:1902903
GeneOntologyBiologicalProcesspositive regulation of actin nucleation

FMN1 WASF2 WASF3

3.02e-0514923GO:0051127
GeneOntologyBiologicalProcessdendritic spine morphogenesis

WASL CUX2 CAMK2B AFDN SHANK3

3.10e-0581925GO:0060997
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase II

FOXO1 BCL9L WASL SFPQ ZNF219 SRA1 WAS HOXD3 ATOH8 PIK3R2 ZNF335 SOX18 POU3F1 ZFPM1 DBP MAPK7 NR1D1 CCNK

3.62e-0513909218GO:0045944
GeneOntologyBiologicalProcessnegative regulation of actin filament bundle assembly

WAS WASF2 SHANK3 ARAP1

4.80e-0545924GO:0032232
GeneOntologyBiologicalProcessregulation of cytoskeleton organization

WAS FMN1 PIK3R2 WASF2 WASF3 ARHGAP17 DAAM2 FHOD3 SHANK3 VASP ARAP1

5.33e-055799211GO:0051493
GeneOntologyBiologicalProcesscell morphogenesis

BCL9L WASL CUX2 ATXN2 CAMK2B WASF2 ZNF335 WASF3 AFDN ZFPM1 PALLD SHANK3 FMNL1 VASP CAP1 ARAP1

7.03e-0511949216GO:0000902
GeneOntologyBiologicalProcessprotein polymerization

WASL WAS FMN1 PIK3R2 WASF3 DAAM2 FHOD3 VASP

1.24e-04334928GO:0051258
GeneOntologyBiologicalProcessregulation of actin polymerization or depolymerization

WAS FMN1 PIK3R2 DAAM2 FHOD3 VASP

1.42e-04177926GO:0008064
GeneOntologyBiologicalProcessregulation of actin filament length

WAS FMN1 PIK3R2 DAAM2 FHOD3 VASP

1.56e-04180926GO:0030832
GeneOntologyBiologicalProcessenergy reserve metabolic process

ADRB1 IRS1 IRS2 NR1D1 SELENON

1.58e-04114925GO:0006112
GeneOntologyBiologicalProcessdendritic spine organization

WASL CUX2 CAMK2B AFDN SHANK3

1.65e-04115925GO:0097061
GeneOntologyBiologicalProcessregulation of dendritic spine morphogenesis

CUX2 CAMK2B AFDN SHANK3

1.92e-0464924GO:0061001
GeneOntologyBiologicalProcessactin filament bundle assembly

WAS PIK3R2 WASF2 FMN2 SHANK3 ARAP1

2.15e-04191926GO:0051017
GeneOntologyBiologicalProcessregulation of actin filament bundle assembly

WAS PIK3R2 WASF2 SHANK3 ARAP1

2.26e-04123925GO:0032231
GeneOntologyBiologicalProcessactin filament bundle organization

WAS PIK3R2 WASF2 FMN2 SHANK3 ARAP1

2.40e-04195926GO:0061572
GeneOntologyBiologicalProcesscentral nervous system development

SETD1A ATN1 UNCX ATXN2 ZIC5 ZNF335 WASF3 DAAM2 AFDN POU3F1 IRS2 NR1D1 SEZ6L2 BAG6 SHANK3

2.53e-0411979215GO:0007417
GeneOntologyBiologicalProcessneuron projection organization

WASL CUX2 CAMK2B AFDN SHANK3

2.62e-04127925GO:0106027
GeneOntologyBiologicalProcesspositive regulation of dendritic spine development

CUX2 CAMK2B AFDN SHANK3

2.71e-0470924GO:0060999
GeneOntologyBiologicalProcessregulation of cell morphogenesis

BCL9L CUX2 CAMK2B WASF3 AFDN FMNL1 ARAP1

4.07e-04302927GO:0022604
GeneOntologyBiologicalProcessdendritic spine development

WASL CUX2 CAMK2B AFDN SHANK3

4.24e-04141925GO:0060996
GeneOntologyBiologicalProcesspositive regulation of dendritic spine morphogenesis

CUX2 CAMK2B AFDN

4.65e-0434923GO:0061003
GeneOntologyBiologicalProcesspositive regulation of Arp2/3 complex-mediated actin nucleation

WASF2 WASF3

5.41e-048922GO:2000601
GeneOntologyBiologicalProcessregulation of actin filament polymerization

FMN1 PIK3R2 DAAM2 FHOD3 VASP

6.72e-04156925GO:0030833
GeneOntologyBiologicalProcessnegative regulation of stress fiber assembly

WAS WASF2 ARAP1

6.99e-0439923GO:0051497
GeneOntologyBiologicalProcessregulation of dendritic spine development

CUX2 CAMK2B AFDN SHANK3

7.37e-0491924GO:0060998
GeneOntologyBiologicalProcessregulation of actin nucleation

FMN1 WASF2 WASF3

8.10e-0441923GO:0051125
GeneOntologyBiologicalProcessregulation of organelle organization

SFPQ WAS FMN1 CAMK2B PIK3R2 WASF2 WASF3 SMARCC2 ARHGAP17 DAAM2 FHOD3 CNTROB SHANK3 VASP ARAP1

8.39e-0413429215GO:0033043
GeneOntologyBiologicalProcessregulation of plasma membrane bounded cell projection assembly

WASL WAS WASF2 DAAM2 CNTROB ARAP1

8.56e-04248926GO:0120032
GeneOntologyBiologicalProcessregulation of cell projection assembly

WASL WAS WASF2 DAAM2 CNTROB ARAP1

9.11e-04251926GO:0060491
GeneOntologyBiologicalProcesspositive regulation of excitatory postsynaptic potential

CUX2 AFDN SHANK3

9.31e-0443923GO:2000463
GeneOntologyBiologicalProcesssynapse organization

WASL CUX2 CAMK2B WASF2 WASF3 AFDN SEZ6L2 PALLD SHANK3 CAP1

9.50e-046859210GO:0050808
GeneOntologyCellularComponentchromatin

FOXO1 SETD1A KLF16 CUX2 SFPQ IRX5 HOXD3 UNCX RBL2 ATOH8 ZFHX2 SMARCC2 SOX18 POU3F1 ZFPM1 DBP KMT2E NR1D1 RING1

1.68e-0514809119GO:0000785
GeneOntologyCellularComponentSCAR complex

SRA1 WASF2 WASF3

1.71e-0512913GO:0031209
GeneOntologyCellularComponentactin cytoskeleton

WASL WAS FMN1 WASF2 FMN2 FHOD3 MYO15A PALLD VASP CAP1

2.02e-045769110GO:0015629
GeneOntologyCellularComponentcell leading edge

WASL SRA1 ATN1 WASF2 WASF3 FIGNL2 HCN2 PALLD VASP

3.29e-04500919GO:0031252
GeneOntologyCellularComponentnuclear body

CBLL1 SETD1A SFPQ HOXD3 ATOH8 PTPN23 AFDN MAPK7 KMT2E NR1D1 SF1 RING1

5.36e-049039112GO:0016604
DomainFH2

FMN1 FMN2 DAAM2 FHOD3 FMNL1

6.71e-0915905PS51444
DomainFH2_Formin

FMN1 FMN2 DAAM2 FHOD3 FMNL1

6.71e-0915905IPR015425
DomainFH2

FMN1 FMN2 DAAM2 FHOD3 FMNL1

6.71e-0915905PF02181
DomainFH2

FMN1 FMN2 DAAM2 FHOD3 FMNL1

6.71e-0915905SM00498
DomainWH2

WASL WAS WASF2 WASF3

4.86e-0714904SM00246
DomainWH2

WASL WAS WASF2 WASF3

8.78e-0716904PF02205
DomainWH2_dom

WASL WAS WASF2 WASF3

2.83e-0621904IPR003124
DomainWH2

WASL WAS WASF2 WASF3

4.98e-0624904PS51082
DomainDAD_dom

DAAM2 FHOD3 FMNL1

5.95e-068903IPR014767
DomainDAD

DAAM2 FHOD3 FMNL1

5.95e-068903PS51231
DomainWH1

WASL WAS VASP

1.74e-0511903SM00461
DomainGBD/FH3_dom

DAAM2 FHOD3 FMNL1

1.74e-0511903IPR014768
DomainWH1/EVH1_dom

WASL WAS VASP

1.74e-0511903IPR000697
DomainWH1

WASL WAS VASP

1.74e-0511903PF00568
DomainGBD_FH3

DAAM2 FHOD3 FMNL1

1.74e-0511903PS51232
DomainCECR6_TMEM121

TMEM121B TMEM121

2.30e-052902PF14997
DomainCECR6/TMEM121

TMEM121B TMEM121

2.30e-052902IPR032776
DomainWASPfam_EVH1

WASL WAS

2.30e-052902IPR033927
DomainWH1

WASL WAS VASP

2.99e-0513903PS50229
DomainSCAR/WAVE_fam

WASF2 WASF3

6.87e-053902IPR028288
DomainHomeobox_CS

CUX2 IRX5 HOXD3 UNCX ZFHX2 POU3F1

2.80e-04186906IPR017970
Domain-

CUX2 IRX5 HOXD3 UNCX ZFHX2 SMARCC2 POU3F1

4.35e-042839071.10.10.60
DomainWASP_C

WASL WAS

4.75e-047902IPR011026
DomainCYCLIN

CABLES2 RBL2 CCNK

8.08e-0438903SM00385
DomainDrf_GBD

DAAM2 FMNL1

8.09e-049902PF06371
DomainFH3_dom

DAAM2 FMNL1

8.09e-049902IPR010472
DomainGTPase-bd

DAAM2 FMNL1

8.09e-049902IPR010473
DomainDrf_FH3

DAAM2 FMNL1

8.09e-049902PF06367
DomainMYTH4

MYO15B MYO15A

8.09e-049902PS51016
DomainMyTH4_dom

MYO15B MYO15A

8.09e-049902IPR000857
DomainMyTH4

MYO15B MYO15A

8.09e-049902PF00784
DomainDrf_FH3

DAAM2 FMNL1

8.09e-049902SM01139
DomainDrf_GBD

DAAM2 FMNL1

8.09e-049902SM01140
DomainMyTH4

MYO15B MYO15A

8.09e-049902SM00139
Domain-

CABLES2 RBL2 CCNK

9.40e-04409031.10.472.10
DomainHomeobox

CUX2 IRX5 HOXD3 UNCX ZFHX2 POU3F1

9.40e-04234906PF00046
DomainHOMEOBOX_1

CUX2 IRX5 HOXD3 UNCX ZFHX2 POU3F1

9.82e-04236906PS00027
DomainHOX

CUX2 IRX5 HOXD3 UNCX ZFHX2 POU3F1

1.00e-03237906SM00389
DomainSET

SETD1A KMT2B KMT2E

1.01e-0341903PF00856
DomainHOMEOBOX_2

CUX2 IRX5 HOXD3 UNCX ZFHX2 POU3F1

1.05e-03239906PS50071
DomainHomeobox_dom

CUX2 IRX5 HOXD3 UNCX ZFHX2 POU3F1

1.05e-03239906IPR001356
DomainHomeodomain-like

CUX2 IRX5 HOXD3 UNCX ZFHX2 SMARCC2 POU3F1

1.11e-03332907IPR009057
DomainCyclin-like

CABLES2 RBL2 CCNK

1.16e-0343903IPR013763
DomainPTBI

IRS1 IRS2

1.23e-0311902SM00310
DomainSET

SETD1A KMT2B KMT2E

1.41e-0346903SM00317
Domain-

WASL WAS

1.47e-03129023.90.810.10
DomainIRS_PTB

IRS1 IRS2

1.47e-0312902PS51064
Domain-

ZNF787 CBLL1 KLF16 ZBTB45 ZNF219 ZIC5 ZNF335 ZFHX2 ZFPM1 ZNF579

1.57e-0367990103.30.160.60
DomainSET_dom

SETD1A KMT2B KMT2E

1.80e-0350903IPR001214
DomainSET

SETD1A KMT2B KMT2E

1.80e-0350903PS50280
DomainZnf_C2H2/integrase_DNA-bd

ZNF787 CBLL1 KLF16 ZBTB45 ZNF219 ZIC5 ZNF335 ZFHX2 ZFPM1 ZNF579

1.85e-036949010IPR013087
DomainIRS_PTB

IRS1 IRS2

2.01e-0314902IPR002404
DomainIRS

IRS1 IRS2

2.01e-0314902PF02174
DomainPost-SET_dom

SETD1A KMT2B

2.64e-0316902IPR003616
DomainPostSET

SETD1A KMT2B

2.64e-0316902SM00508
DomainPBD

WASL WAS

2.64e-0316902SM00285
DomainPOST_SET

SETD1A KMT2B

2.64e-0316902PS50868
DomainPBD

WASL WAS

2.98e-0317902PF00786
DomainRhoGAP

PIK3R2 ARHGAP17 ARAP1

3.33e-0362903SM00324
DomainRhoGAP

PIK3R2 ARHGAP17 ARAP1

3.49e-0363903PF00620
DomainRHOGAP

PIK3R2 ARHGAP17 ARAP1

3.65e-0364903PS50238
DomainRhoGAP_dom

PIK3R2 ARHGAP17 ARAP1

3.65e-0364903IPR000198
Domain-

PIK3R2 ARHGAP17 ARAP1

3.65e-03649031.10.555.10
DomainSH3

MYO15B PIK3R2 RUSC1 MYO15A SHANK3

3.92e-03216905SM00326
DomainSH3

MYO15B PIK3R2 RUSC1 MYO15A SHANK3

3.92e-03216905PS50002
DomainZINC_FINGER_C2H2_2

ZNF787 CBLL1 KLF16 ZBTB45 ZNF219 ZIC5 ZNF335 ZFHX2 ZFPM1 ZNF579

4.09e-037759010PS50157
DomainCRIB

WASL WAS

4.12e-0320902PS50108
DomainZINC_FINGER_C2H2_1

ZNF787 CBLL1 KLF16 ZBTB45 ZNF219 ZIC5 ZNF335 ZFHX2 ZFPM1 ZNF579

4.16e-037779010PS00028
DomainSH3_domain

MYO15B PIK3R2 RUSC1 MYO15A SHANK3

4.23e-03220905IPR001452
DomainSAM_1

SEC23IP SHANK3 ARAP1

4.33e-0368903PF00536
DomainCRIB_dom

WASL WAS

4.54e-0321902IPR000095
PathwayREACTOME_RAC1_GTPASE_CYCLE

WASL WAS PIK3R2 WASF2 WASF3 ARHGAP17 FMNL1 ARAP1

3.07e-06184698M41809
PathwayWP_ANGIOPOIETINLIKE_PROTEIN_8_REGULATORY_PATHWAY

FOXO1 MAP4K1 PIK3R2 IRS1 IRS2 MAPK7 CAP1

3.58e-06132697M39338
PathwayKEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS

WASL WAS PIK3R2 WASF2 WASF3 VASP

7.23e-0696696M16121
PathwayREACTOME_PI3K_AKT_ACTIVATION

PIK3R2 IRS1 IRS2

9.23e-069693M714
PathwayWP_INSULIN_SIGNALING

FOXO1 MAP4K1 PIK3R2 IRS1 IRS2 MAPK7 CAP1

1.27e-05160697M39482
PathwayBIOCARTA_ACTINY_PATHWAY

WASL WASF2 WASF3

1.31e-0510693MM1528
PathwayBIOCARTA_ACTINY_PATHWAY

WASL WASF2 WASF3

2.39e-0512693M7825
PathwayREACTOME_RHO_GTPASES_ACTIVATE_WASPS_AND_WAVES

WASL WAS WASF2 WASF3

2.75e-0536694M27549
PathwayKEGG_ADHERENS_JUNCTION

WASL WAS WASF2 WASF3 AFDN

2.81e-0573695M638
PathwayREACTOME_RET_SIGNALING

PIK3R2 IRS2 MAPK7 SHANK3

3.42e-0538694MM15493
PathwayWP_G13_SIGNALING_PATHWAY

WASL SRA1 WAS PIK3R2

3.80e-0539694MM15898
PathwayREACTOME_CDC42_GTPASE_CYCLE

WASL WAS PIK3R2 ARHGAP17 FMNL1 ARAP1

1.09e-04155696M41808
PathwaySIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES

FOXO1 IRS1 IRS2 CAP1

1.10e-0451694M7955
PathwayWP_INSULIN_SIGNALING

FOXO1 MAP4K1 PIK3R2 IRS1 MAPK7 CAP1

1.29e-04160696MM15956
PathwayWP_FOXA2_PATHWAY

FOXO1 IRS1 IRS2

1.40e-0421693M42579
PathwayWP_TRANSCRIPTION_FACTOR_REGULATION_IN_ADIPOGENESIS

FOXO1 IRS1 IRS2

1.62e-0422693M39414
PathwayREACTOME_RAC1_GTPASE_CYCLE

PIK3R2 WASF2 WASF3 ARHGAP17 FMNL1 ARAP1

2.11e-04175696MM15599
PathwayREACTOME_IRS_ACTIVATION

IRS1 IRS2

2.34e-045692M27707
PathwaySIG_IL4RECEPTOR_IN_B_LYPHOCYTES

MAP4K1 IRS1 IRS2

3.02e-0427693M1718
PathwayKEGG_NEUROTROPHIN_SIGNALING_PATHWAY

CAMK2B PIK3R2 IRS1 IRS2 MAPK7

3.75e-04126695M16763
PathwayPID_PDGFRB_PATHWAY

WASL PIK3R2 WASF2 AFDN ARAP1

4.18e-04129695M186
PathwayREACTOME_SOS_MEDIATED_SIGNALLING

IRS1 IRS2

4.88e-047692M19489
PathwayWP_ALPHA_6_BETA_4_SIGNALING

PIK3R2 IRS1 IRS2

5.51e-0433693M39503
PathwayREACTOME_PI3K_AKT_ACTIVATION

PIK3R2 IRS2

6.49e-048692MM14776
PathwayREACTOME_FCGAMMA_RECEPTOR_FCGR_DEPENDENT_PHAGOCYTOSIS

WASL WAS PIK3R2 WASF2 WASF3

6.68e-04143695M27107
PathwayREACTOME_INTERLEUKIN_7_SIGNALING

PIK3R2 IRS1 IRS2

7.14e-0436693M542
PathwayREACTOME_INTRACELLULAR_SIGNALING_BY_SECOND_MESSENGERS

FOXO1 ATN1 CAMK2B PIK3R2 IRS1 IRS2 RING1

8.26e-04313697M27867
PathwayWP_G13_SIGNALING

WASL WAS PIK3R2

8.37e-0438693M39606
PathwayPID_RET_PATHWAY

IRS1 IRS2 SHANK3

9.04e-0439693M82
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX1

SETD1A KMT2B SMARCC2 ZFPM1 RING1

9.07e-04153695MM15522
PathwayREACTOME_RET_SIGNALING

PIK3R2 IRS2 MAPK7

9.74e-0440693M27746
PathwayREACTOME_SIGNAL_ATTENUATION

IRS1 IRS2

1.04e-0310692M14236
PathwayKEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION

PIK3R2 IRS1 IRS2

1.12e-0342693M16473
PathwayWP_EGFEGFR_SIGNALING

FOXO1 ATXN2 MAP4K1 PIK3R2 MAPK7

1.17e-03162695M39334
PathwayWP_IL7_SIGNALING_PATHWAY

FOXO1 IRS1 IRS2

1.20e-0343693MM15864
PathwayREACTOME_SIGNALING_BY_LEPTIN

IRS1 IRS2

1.26e-0311692M27195
PathwayREACTOME_RUNX1_REGULATES_GENES_INVOLVED_IN_MEGAKARYOCYTE_DIFFERENTIATION_AND_PLATELET_FUNCTION

SETD1A KMT2B ZFPM1

1.29e-0344693MM15527
PathwayREACTOME_SIGNALING_BY_LTK

PIK3R2 IRS1

1.51e-0312692M48256
PathwayREACTOME_RHO_GTPASE_CYCLE

WASL WAS PIK3R2 WASF2 WASF3 ARHGAP17 FMNL1 ARAP1

1.54e-03450698M27078
PathwayKEGG_TYPE_II_DIABETES_MELLITUS

PIK3R2 IRS1 IRS2

1.56e-0347693M19708
PathwayREACTOME_IRS_MEDIATED_SIGNALLING

PIK3R2 IRS1 IRS2

1.66e-0348693M26916
PathwayPID_ERBB1_DOWNSTREAM_PATHWAY

WASL PIK3R2 WASF2 MAPK7

1.73e-03105694M164
PathwayWP_SYNAPTIC_SIGNALING_ASSOCIATED_WITH_AUTISM_SPECTRUM_DISORDER

CAMK2B PIK3R2 SHANK3

1.87e-0350693M39822
PathwayREACTOME_PI3K_AKT_SIGNALING_IN_CANCER

FOXO1 PIK3R2 IRS1 IRS2

2.05e-03110694M27162
PathwayWP_IL4_SIGNALING

PIK3R2 IRS1 IRS2

2.33e-0354693M39720
PathwayREACTOME_SIGNALING_BY_TYPE_1_INSULIN_LIKE_GROWTH_FACTOR_1_RECEPTOR_IGF1R

PIK3R2 IRS1 IRS2

2.33e-0354693M27168
PathwayREACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE

PIK3R2 IRS1 IRS2

2.33e-0354693M620
PathwayWP_INTERFERON_TYPE_I_SIGNALING

PIK3R2 IRS1 IRS2

2.33e-0354693M39435
PathwayREACTOME_INTERLEUKIN_7_SIGNALING

PIK3R2 IRS2

2.38e-0315692MM14536
PathwayREACTOME_RHOJ_GTPASE_CYCLE

WASL WAS PIK3R2

2.45e-0355693M41815
PathwayREACTOME_PARASITE_INFECTION

WASL WAS WASF2 WASF3

2.49e-03116694M29843
Pubmed

WW domains provide a platform for the assembly of multiprotein networks.

WASL SFPQ SF3B4 WAS WASF2 FIP1L1 SMARCC2 CCNK FMNL1 VASP SF1

3.99e-13154931116055720
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

KMT2B ATN1 OTUD5 MAP4K1 ZNF335 PPP1R18 FIP1L1 SMARCC2 AFDN IRS2 ZFPM1 ZNF579 NR1D1 CCNK BAG6 SF1

2.41e-10774931615302935
Pubmed

Expression of multiple formins in adult tissues and during developmental stages of mouse brain.

FMN1 FMN2 DAAM2 FHOD3 FMNL1

2.41e-101493526272686
Pubmed

Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex.

WASL WAS WASF2 WASF3

3.33e-09893410381382
Pubmed

Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex.

WASL WAS WASF2 WASF3

3.33e-09893411146629
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

ZNF787 FOXO1 CUX2 CITED4 ZNF219 HOXD3 ATOH8 ZFHX2 SOX18 AFDN POU3F1 NR1D1 SF1 RING1

6.34e-09709931422988430
Pubmed

Tamoxifen reduces fat mass by boosting reactive oxygen species.

FOXO1 IRS1 IRS2

1.85e-08393325569103
Pubmed

Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation.

FOXO1 IRS1 IRS2

1.85e-08393318590693
Pubmed

Proline-rich sequence recognition: II. Proteomics analysis of Tsg101 ubiquitin-E2-like variant (UEV) interactions.

SFPQ ATXN2 SEC23IP BAG6 VASP

2.33e-083293519542561
Pubmed

Impact of cytosine methylation on DNA binding specificities of human transcription factors.

ZNF787 KLF16 ZBTB45 CUX2 IRX5 HOXD3 UNCX ZIC5 SOX18 POU3F1 DBP NR1D1

2.51e-08544931228473536
Pubmed

WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelination.

WASL WAS WASF2 WASF3

3.36e-081393416723544
Pubmed

Insulin inhibits cardiac contractility by inducing a Gi-biased β2-adrenergic signaling in hearts.

ADRB1 IRS1 IRS2

7.39e-08493324677713
Pubmed

FoxO1 suppresses Fgf21 during hepatic insulin resistance to impair peripheral glucose utilization and acute cold tolerance.

FOXO1 IRS1 IRS2

7.39e-08493333761350
Pubmed

Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.

WASL SFPQ SF3B4 KMT2B WASF2 FMN2 SMARCC2 CCNK VASP SF1 CAP1

1.16e-07506931130890647
Pubmed

A census of human transcription factors: function, expression and evolution.

FOXO1 KLF16 CUX2 IRX5 HOXD3 UNCX ATOH8 ZNF335 ZFHX2 SOX18 POU3F1 ZFPM1 DBP NR1D1

1.36e-07908931419274049
Pubmed

FBP11 regulates nuclear localization of N-WASP and inhibits N-WASP-dependent microspike formation.

WASL WASF2 WASF3

1.84e-07593314697212
Pubmed

Hepatic p38α MAPK controls gluconeogenesis via FOXO1 phosphorylation at S273 during glucagon signalling in mice.

FOXO1 IRS1 IRS2

1.84e-07593337202506
Pubmed

Feedback regulation of hepatic gluconeogenesis through modulation of SHP/Nr0b2 gene expression by Sirt1 and FoxO1.

FOXO1 IRS1 IRS2

1.84e-07593321081708
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

SETD1A CUX2 ATN1 ATXN2 MAP4K1 PIK3R2 KMT2E VASP ARAP1 C6orf132

2.44e-07430931035044719
Pubmed

Proteomic investigation of the interactome of FMNL1 in hematopoietic cells unveils a role in calcium-dependent membrane plasticity.

ZNF787 ARHGAP17 TOMM40 FMNL1 CAP1

2.89e-075293523182705
Pubmed

CIN85 interacting proteins in B cells-specific role for SHIP-1.

WASL WAS MAP4K1 ARHGAP17 ARAP1

3.50e-075493521725061
Pubmed

Inactivating hepatic follistatin alleviates hyperglycemia.

FOXO1 IRS1 IRS2

3.68e-07693329867232
Pubmed

Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B.

PIK3R2 IRS1 IRS2

1.03e-06893312167717
Pubmed

Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.

SETD1A KMT2B KMT2E

1.03e-06893323130995
Pubmed

Recognition sequences for the GYF domain reveal a possible spliceosomal function of CD2BP2.

SFPQ SF3B4 SF1

2.19e-061093315105431
Pubmed

Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.

WASL SF3B4 KMT2B MAP4K1 SMARCC2 HCN2 SELENON SHANK3

2.98e-0632993817474147
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

FOXO1 SF3B4 MAP4K1 FMN2 FIP1L1 ARHGAP17 AFDN IRS1 IRS2 PALLD ENKD1 C6orf132

3.26e-06861931236931259
Pubmed

Growth hormone and prolactin stimulate tyrosine phosphorylation of insulin receptor substrate-1, -2, and -3, their association with p85 phosphatidylinositol 3-kinase (PI3-kinase), and concomitantly PI3-kinase activation via JAK2 kinase.

PIK3R2 IRS1 IRS2

4.00e-06129339624169
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

WASL SFPQ SF3B4 ATN1 PIK3R2 WASF2 FIP1L1 SMARCC2 IRS1 ACBD3 VASP SF1 CAP1 RING1

5.70e-061247931427684187
Pubmed

A WASp-VASP complex regulates actin polymerization at the plasma membrane.

WAS VASP

7.07e-06293211598004
Pubmed

Neural Wiskott-Aldrich syndrome protein modulates Wnt signaling and is required for hair follicle cycling in mice.

WASL WAS

7.07e-06293220071778
Pubmed

Clearance of HCV improves insulin resistance, beta-cell function, and hepatic expression of insulin receptor substrate 1 and 2.

IRS1 IRS2

7.07e-06293217222321
Pubmed

Insulin receptor substrate-1/2 mediates IL-4-induced migration of human airway epithelial cells.

IRS1 IRS2

7.07e-06293219447894
Pubmed

Divergent roles for IRS-1 and IRS-2 in breast cancer metastasis.

IRS1 IRS2

7.07e-06293217361103
Pubmed

N-WASP has the ability to compensate for the loss of WASP in macrophage podosome formation and chemotaxis.

WASL WAS

7.07e-06293220599953
Pubmed

Disruption of IRS-2 causes type 2 diabetes in mice.

IRS1 IRS2

7.07e-0629329495343
Pubmed

Phosphorylation of insulin receptor substrates (IRS-1 and IRS-2) is attenuated following cecal ligation and puncture in mice.

IRS1 IRS2

7.07e-06293237550630
Pubmed

Insulin receptor substrate 1, but not IRS2, plays a dominant role in regulating pancreatic alpha cell function in mice.

IRS1 IRS2

7.07e-06293233839150
Pubmed

Roles of Insulin Receptor Substrates (IRS) in renal function and renal hemodynamics.

IRS1 IRS2

7.07e-06293233270683
Pubmed

Identification and characterization of human DAAM2 gene in silico.

DAAM2 FMNL1

7.07e-06293212632087
Pubmed

Roles of insulin receptor substrates in insulin-induced stimulation of renal proximal bicarbonate absorption.

IRS1 IRS2

7.07e-06293215975995
Pubmed

Systematic modeling for the insulin signaling network mediated by IRS(1) and IRS(2).

IRS1 IRS2

7.07e-06293224703981
Pubmed

Wiskott-Aldrich syndrome: a comprehensive review.

WASL WAS

7.07e-06293223527602
Pubmed

Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity.

IRS1 IRS2

7.07e-06293227708333
Pubmed

Neuronal Wiskott-Aldrich syndrome protein regulates Pseudomonas aeruginosa-induced lung vascular permeability through the modulation of actin cytoskeletal dynamics.

WASL WAS

7.07e-06293231916311
Pubmed

Impairment of bone healing by insulin receptor substrate-1 deficiency.

IRS1 IRS2

7.07e-06293214736890
Pubmed

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice.

IRS1 IRS2

7.07e-06293217928362
Pubmed

Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle.

IRS1 IRS2

7.07e-06293221356519
Pubmed

The study on the relationship between IRS-1 Gly972Arg and IRS-2 Gly1057Asp polymorphisms and type 2 diabetes in the Kurdish ethnic group in West Iran.

IRS1 IRS2

7.07e-06293222994406
Pubmed

Palladin promotes assembly of non-contractile dorsal stress fibers through VASP recruitment.

PALLD VASP

7.07e-06293224496446
Pubmed

Caspase-mediated Cleavage of Insulin Receptor Substrate.

IRS1 IRS2

7.07e-06293215069074
Pubmed

The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis.

IRS1 IRS2

7.07e-06293219596788
Pubmed

Novel roles of hakai in cell proliferation and oncogenesis.

CBLL1 SFPQ

7.07e-06293219535458
Pubmed

Insulin receptor substrate (IRS)-2, not IRS-1, protects human neuroblastoma cells against apoptosis.

IRS1 IRS2

7.07e-06293219259821
Pubmed

Lack of insulin receptor substrate-2 causes progressive neointima formation in response to vessel injury.

IRS1 IRS2

7.07e-06293212810606
Pubmed

Overexpression of insulin receptor substrate-1, but not insulin receptor substrate-2, protects a T cell hybridoma from activation-induced cell death.

IRS1 IRS2

7.07e-06293212055235
Pubmed

Role of allelic variants Gly972Arg of IRS-1 and Gly1057Asp of IRS-2 in moderate-to-severe insulin resistance of women with polycystic ovary syndrome.

IRS1 IRS2

7.07e-06293211522686
Pubmed

Association of IRS1 (Gly972Arg) and IRS2 (Gly1057Asp) genes polymorphisms with OSA and NAFLD in Asian Indians.

IRS1 IRS2

7.07e-06293234449768
Pubmed

The ability to induce microtubule acetylation is a general feature of formin proteins.

FMN1 FMN2

7.07e-06293223110170
Pubmed

The mouse formin, FRLalpha, slows actin filament barbed end elongation, competes with capping protein, accelerates polymerization from monomers, and severs filaments.

FMN1 FMNL1

7.07e-06293214990563
Pubmed

Irs1 serine 307 promotes insulin sensitivity in mice.

IRS1 IRS2

7.07e-06293220074531
Pubmed

Role of IRS-2 in insulin and cytokine signalling.

IRS1 IRS2

7.07e-0629327675087
Pubmed

Selective insulin resistance with differential expressions of IRS-1 and IRS-2 in human NAFLD livers.

IRS1 IRS2

7.07e-06293229717275
Pubmed

Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2(-/-) mouse liver.

IRS1 IRS2

7.07e-06293211546755
Pubmed

Increased insulin resistance in obese children who have both 972 IRS-1 and 1057 IRS-2 polymorphisms.

IRS1 IRS2

7.07e-06293212475767
Pubmed

Variations in insulin secretion in carriers of gene variants in IRS-1 and -2.

IRS1 IRS2

7.07e-06293211872698
Pubmed

N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility.

WASL WAS

7.07e-06293211584271
Pubmed

Essential role of insulin receptor substrate 1 (IRS-1) and IRS-2 in adipocyte differentiation.

IRS1 IRS2

7.07e-06293211259600
Pubmed

Relationship of insulin receptor substrate-1 and -2 genotypes to phenotypic features of polycystic ovary syndrome.

IRS1 IRS2

7.07e-06293212213887
Pubmed

Association of IRS-1 and IRS-2 genes polymorphisms with polycystic ovary syndrome: a meta-analysis.

IRS1 IRS2

7.07e-06293222523112
Pubmed

Selective Insulin Resistance in the Kidney.

IRS1 IRS2

7.07e-06293227247938
Pubmed

Decreased lactation capacity and altered milk composition in insulin receptor substrate null mice is associated with decreased maternal body mass and reduced insulin-dependent phosphorylation of mammary Akt.

IRS1 IRS2

7.07e-06293217641282
Pubmed

Night-Shift Work Duration and Risk of Colorectal Cancer According to IRS1 and IRS2 Expression.

IRS1 IRS2

7.07e-06293231666286
Pubmed

Differential involvement of insulin receptor substrate (IRS)-1 and IRS-2 in brain insulin signaling is associated with the effects on amyloid pathology in a mouse model of Alzheimer's disease.

IRS1 IRS2

7.07e-06293234537327
Pubmed

Association of Gly972Arg variant of insulin receptor subtrate-1 and Gly1057Asp variant of insulin receptor subtrate-2 with polycystic ovary syndrome in the Chinese population.

IRS1 IRS2

7.07e-06293225310961
Pubmed

N-WASP-dependent branched actin polymerization attenuates B-cell receptor signaling by increasing the molecular density of receptor clusters.

WASL WAS

7.07e-06293238085658
Pubmed

Insulin Receptor Substrate Adaptor Proteins Mediate Prognostic Gene Expression Profiles in Breast Cancer.

IRS1 IRS2

7.07e-06293226991655
Pubmed

Overexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human beta-cells from hyperglycemia-induced apoptosis.

IRS1 IRS2

7.07e-06293215572028
Pubmed

Association of IRS-1 and IRS-2 polymorphisms with predisposition to type-2 diabetes (T2D): a meta-analysis and trial sequential analysis.

IRS1 IRS2

7.07e-06293237173295
Pubmed

Formin-1 protein associates with microtubules through a peptide domain encoded by exon-2.

FMN1 FMNL1

7.07e-06293216480715
Pubmed

Insulin receptor substrates are essential for the bioenergetic and hypertrophic response of the heart to exercise training.

IRS1 IRS2

7.07e-06293225002528
Pubmed

Diversification of cardiac insulin signaling involves the p85 alpha/beta subunits of phosphatidylinositol 3-kinase.

PIK3R2 IRS1

7.07e-06293211120660
Pubmed

Targeting type 2 diabetes: lessons from a knockout model of insulin receptor substrate 2.

IRS1 IRS2

7.07e-06293224977713
Pubmed

Down-regulation of Insulin Receptor Substrate 1 during Hyperglycemia Induces Vascular Smooth Muscle Cell Dedifferentiation.

IRS1 IRS2

7.07e-06293228003360
Pubmed

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

IRS1 IRS2

7.07e-06293211078455
Pubmed

PDGF-induced vascular smooth muscle cell proliferation is associated with dysregulation of insulin receptor substrates.

IRS1 IRS2

7.07e-06293221325637
Pubmed

X-ray scattering study of activated Arp2/3 complex with bound actin-WCA.

WASL WAS

7.07e-06293218462674
Pubmed

Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2.

IRS1 IRS2

7.07e-06293217374994
Pubmed

Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth.

IRS1 IRS2

7.07e-06293216374520
Pubmed

Study of association of IRS-1 and IRS-2 genes polymorphisms with clinical and metabolic features in women with polycystic ovary syndrome. Is there an impact?

IRS1 IRS2

7.07e-06293220210696
Pubmed

Developmental and hormonal signals dramatically alter the localization and abundance of insulin receptor substrate proteins in the mammary gland.

IRS1 IRS2

7.07e-06293212746333
Pubmed

Prevalence of the insulin receptor substrate-1(IRS-1) Gly972Arg and the insulin receptor substrate-2(IRS-2) Gly1057Asp polymorphisms in PCOS patients and non-diabetic healthy women.

IRS1 IRS2

7.07e-06293222205343
Pubmed

Insulin receptor substrates 1 and 2 but not Shc can activate the insulin receptor independent of insulin and induce proliferation in CHO-IR cells.

IRS1 IRS2

7.07e-06293217222824
Pubmed

N-WASP and WAVE2 acting downstream of phosphatidylinositol 3-kinase are required for myogenic cell migration induced by hepatocyte growth factor.

WASL WASF2

7.07e-06293215496413
Pubmed

Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development.

WASL WAS

7.07e-06293217878299
Pubmed

Insulin Receptor Substrate-1 (IRS-1) and IRS-2 expression levels are associated with prognosis in non-small cell lung cancer (NSCLC).

IRS1 IRS2

7.07e-06293231393907
Pubmed

Myocardial loss of IRS1 and IRS2 causes heart failure and is controlled by p38α MAPK during insulin resistance.

IRS1 IRS2

7.07e-06293224159000
Pubmed

Inhibition of TNF-α improves the bladder dysfunction that is associated with type 2 diabetes.

IRS1 IRS2

7.07e-06293222688336
Pubmed

Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes.

IRS1 IRS2

7.07e-06293215467829
Pubmed

The reciprocal stability of FOXO1 and IRS2 creates a regulatory circuit that controls insulin signaling.

FOXO1 IRS2

7.07e-06293216916938
InteractionNCK2 interactions

WASL SF3B4 WAS ATN1 MAP4K1 WASF2 WASF3 RBM26 AFDN IRS1 VASP SF1 TMEM121 ARAP1

1.65e-112629314int:NCK2
InteractionPRPF40A interactions

WASL SFPQ SF3B4 KMT2B WAS FMN1 WASF2 WASF3 FIP1L1 SMARCC2 BAG6 FMNL1 VASP SF1

1.66e-084469314int:PRPF40A
InteractionGRB2 interactions

WASL SF3B4 ADRB1 WAS OTUD5 MAP4K1 PIK3R2 WASF2 FIP1L1 PTPN23 ARHGAP17 AFDN IRS1 IRS2 HCN2 SHANK3 VASP ARAP1

2.46e-088069318int:GRB2
InteractionARPC3 interactions

FOXO1 WASL WAS OTUD5 WASF2 BAG6 SHANK3 VASP ARAP1

1.72e-07183939int:ARPC3
InteractionPRMT2 interactions

SETD1A WASL PIK3R2 FIP1L1 BAG6 SHANK3 SF1

2.09e-0791937int:PRMT2
InteractionARHGAP12 interactions

WASL WASF2 WASF3 PALLD SHANK3 SF1

7.13e-0768936int:ARHGAP12
InteractionFMNL1 interactions

ZNF787 FMN1 ARHGAP17 DAAM2 TOMM40 FMNL1 CAP1

7.20e-07109937int:FMNL1
InteractionGAS7 interactions

SFPQ WAS WASF2 FMNL1 SF1

8.35e-0738935int:GAS7
InteractionP4HA3 interactions

ZNF787 NUTM1 KMT2B ATN1 RUSC1 ZNF579 SF1

9.20e-07113937int:P4HA3
InteractionPIK3R3 interactions

FOXO1 KMT2B PIK3R2 RUSC1 IRS1 IRS2 ENKD1 RING1

3.76e-06198938int:PIK3R3
InteractionBAIAP2 interactions

WASL SF3B4 ATN1 WASF2 RBM26 SHANK3 VASP C6orf132

4.20e-06201938int:BAIAP2
InteractionTCERG1 interactions

SETD1A SFPQ SF3B4 WAS FMN1 WASF2 FMNL1 SF1

5.22e-06207938int:TCERG1
InteractionABI2 interactions

WASL MYO15B WASF2 WASF3 RUSC1 SHANK3 VASP ENKD1 CAP1

6.99e-06286939int:ABI2
InteractionPACSIN1 interactions

WASL WAS WASF2 ARHGAP17 SHANK3

8.39e-0660935int:PACSIN1
InteractionTRIP10 interactions

WASL WAS SMARCC2 ARHGAP17 BAG6 SHANK3

1.13e-05109936int:TRIP10
InteractionPFN1 interactions

WASL SFPQ WASF2 FMN2 ARHGAP17 AFDN PALLD FMNL1 VASP CAP1 C6orf132

2.26e-055099311int:PFN1
InteractionRBPMS interactions

ATN1 ATXN2 CAMK2B RUSC1 SMARCC2 C11orf87 CCNK SF1 ENKD1

2.76e-05340939int:RBPMS
InteractionACTB interactions

WASL SRA1 ATXN2 PIK3R2 WASF2 WASF3 SEC23IP FMN2 PPP1R18 SMARCC2 ARHGAP17 MAPK7 PALLD VASP CAP1 C6orf132

3.31e-0510839316int:ACTB
InteractionAPBB1 interactions

WASL SFPQ SF3B4 WAS WASF2 VASP SF1

3.35e-05195937int:APBB1
InteractionLLGL2 interactions

FMN1 RBM26 FIP1L1 BAG6 PALLD SF1

3.51e-05133936int:LLGL2
InteractionYAP1 interactions

FOXO1 BCL9L SETD1A KLF16 WASL SFPQ KMT2B ATN1 RBM26 SMARCC2 AFDN NAA30 NR1D1 CCNK PALLD VASP

3.78e-0510959316int:YAP1
InteractionNCKIPSD interactions

WASL WAS CNTROB PALLD SHANK3 ENKD1

4.15e-05137936int:NCKIPSD
InteractionSORBS3 interactions

WASL MYO15B PPP1R18 AFDN SHANK3 ENKD1 ARAP1

4.19e-05202937int:SORBS3
InteractionSH3GL2 interactions

ZNF219 ADRB1 ATXN2 PTPN23 SHANK3

5.44e-0588935int:SH3GL2
InteractionWASF2 interactions

KLF16 WASL WASF2 WASF3 SHANK3 VASP

5.92e-05146936int:WASF2
InteractionVASP interactions

WAS WASF2 FMN2 PTPN23 IRS2 PALLD VASP C6orf132

6.49e-05294938int:VASP
InteractionTSG101 interactions

SFPQ ATXN2 SEC23IP PTPN23 BAG6 PALLD SHANK3 VASP

8.01e-05303938int:TSG101
InteractionACTC1 interactions

WASL SFPQ SF3B4 KMT2B WAS WASF2 FMN2 SMARCC2 CCNK VASP SF1 CAP1

8.21e-056949312int:ACTC1
InteractionKRTAP19-5 interactions

ATN1 MAPK1IP1L CAMK2B RUSC1 ENKD1

9.54e-0599935int:KRTAP19-5
InteractionACTN4 interactions

FOXO1 WASL SRA1 ATXN2 CAMK2B MAPK7 SHANK3 FMNL1 VASP

9.66e-05400939int:ACTN4
InteractionCDC42 interactions

CBLL1 WASL WAS PIK3R2 WASF2 SEC23IP FMN2 ARHGAP17 AFDN TOMM40 ACBD3 BAG6 PALLD FMNL1 VASP SF1 ARAP1

1.04e-0413239317int:CDC42
InteractionNCK1 interactions

WASL WAS MAP4K1 WASF2 SELENON SHANK3 ARAP1

1.37e-04244937int:NCK1
InteractionWASF3 interactions

WASL PIK3R2 WASF2 WASF3

1.39e-0457934int:WASF3
InteractionNUP35 interactions

BCL9L SFPQ ATN1 ATXN2 SEC23IP AFDN TOMM40 ACBD3 CAP1

1.50e-04424939int:NUP35
InteractionWBP4 interactions

SFPQ SF3B4 WAS FMN1 SF1

1.50e-04109935int:WBP4
InteractionFMN1 interactions

FMN1 FMN2 FMNL1

1.58e-0423933int:FMN1
InteractionSORBS2 interactions

WASL WAS AFDN PALLD SHANK3

1.64e-04111935int:SORBS2
InteractionDIAPH1 interactions

FOXO1 WASL PTPN23 DAAM2 FMNL1 VASP

1.66e-04176936int:DIAPH1
InteractionHNRNPD interactions

FOXO1 KLF16 SFPQ SF3B4 CITED4 SRA1 ATXN2 PPP1R18 SMARCC2 TOMM40 BAG6

1.70e-046389311int:HNRNPD
InteractionAPBB1IP interactions

WASF2 BAG6 VASP

2.03e-0425933int:APBB1IP
InteractionALG13 interactions

ATN1 ATXN2 CCNK VASP SF1 RING1

2.05e-04183936int:ALG13
InteractionCTTN interactions

CBLL1 FOXO1 WASL SFPQ SF3B4 FIP1L1 ARHGAP17 SHANK3 SF1

2.33e-04450939int:CTTN
InteractionDNMBP interactions

WASL PTPN23 ARHGAP17 AFDN VASP

2.74e-04124935int:DNMBP
InteractionTSC1 interactions

SFPQ ATN1 CAMK2B SEC23IP PPP1R18 CNTROB SHANK3 ENKD1

2.92e-04366938int:TSC1
InteractionMEGF11 interactions

ATN1 SHANK3

3.12e-046932int:MEGF11
InteractionSETD1B interactions

SETD1A KMT2B ATN1 RBM26

4.02e-0475934int:SETD1B
InteractionCSNK2A1 interactions

SETD1A CUX2 SFPQ KMT2B WAS ATN1 ATXN2 RBL2 FIP1L1 SMARCC2 IRS1 SHANK3 RING1

4.36e-049569313int:CSNK2A1
GeneFamilyWiskott-Aldrich Syndrome protein family

WASL WAS WASF2 WASF3

2.68e-071665414
GeneFamilyMyosins, class XV|Deafness associated genes|FERM domain containing

MYO15B MYO15A

1.27e-0526521105
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

SETD1A KMT2B KMT2E

2.45e-0434653487
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF787 KLF16 ZBTB45 ZNF219 ZIC5 ZNF335 ZFHX2 ZFPM1 ZNF579

1.02e-0371865928
GeneFamilySterile alpha motif domain containing

SEC23IP SHANK3 ARAP1

3.91e-0388653760
CoexpressionGSE17721_PAM3CSK4_VS_CPG_0.5H_BMDC_UP

COL4A6 WASL ZNF219 HOXD3 ATXN2 WASF2 CCNK

7.38e-06200937M3850
CoexpressionTABULA_MURIS_SENIS_MESENTERIC_ADIPOSE_TISSUE_ENDOTHELIAL_CELL_AGEING

KMT2B RNPEPL1 RBM26 SOX18 AFDN

9.24e-0679935MM3780
CoexpressionBUSSLINGER_DUODENAL_IMMUNE_CELLS

FOXO1 SFPQ SF3B4 WAS RBL2 MAPK1IP1L MAP4K1 RBM26 PPP1R18 KMT2E FMNL1 SF1 CAP1

1.97e-059119313M40038
CoexpressionAtlasDevelopingGonad_e11.5_testes_emap-3226_top-relative-expression-ranked_1000

CBLL1 SFPQ HOXD3 UNCX ATXN2 RBM26 TOMM40 KMT2E FIGN SELENON BAG6 SF1 CAP1 RING1

1.75e-058439314gudmap_developingGonad_e11.5_testes_1000
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FOXO1 BCL9L KLF16 SFPQ IRX5 ATN1 IRS2

1.29e-07186937bd1185592aedebccd1007dbf2dd2f549fcdf9f42
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Epithelial|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FOXO1 KLF16 SFPQ IRX5 ATN1 IRS2 PALLD

1.44e-07189937965e0e388251e7318f8b463816dc96ccb4658677
ToppCellGlobus_pallidus-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cyth3_(Cyth3)-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

SRA1 RBL2 ATOH8 RBM26 SMARCC2 MAPK7

8.37e-07153936553dff9688a1996d8f4ba16e60c683593d781389
ToppCellGlobus_pallidus-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cyth3_(Cyth3)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

SRA1 RBL2 ATOH8 RBM26 SMARCC2 MAPK7

8.37e-0715393688ca2d2c2ab19fbee13e18951b993ee05dd30f67
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FOXO1 PIM2 FMN2 ARHGAP17 IRS1 IRS2

3.32e-0619493611709704079f24a730476572dc2f01e9d2226e2c
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FOXO1 PIM2 FMN2 ARHGAP17 IRS1 IRS2

3.32e-061949363a1f95639d5f239f001bd67d4213e8938e7f299d
ToppCellTCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-4|TCGA-Skin / Sample_Type by Project: Shred V9

ZBTB45 SF3B4 PIK3R2 RNPEPL1 PTPN23 MAPK7

3.84e-06199936bbda9060918797303984ca2b64e9bb73fdacd0c4
ToppCelldroplet-Lung-nan-3m-Myeloid-intermediate_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CITED4 MYO15A NR1D1 FMNL1 CAP1

1.25e-051439354d11d53330a9197275a8851e1bbf55a113715a09
ToppCelldroplet-Lung-nan-3m-Myeloid-Intermediate_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CITED4 MYO15A NR1D1 FMNL1 CAP1

1.25e-051439358b9f4d87d5faac7752c83e1992491fc5550600f8
ToppCellE18.5-samps-Mesenchymal-Matrix_fibroblast-FB-1|E18.5-samps / Age Group, Lineage, Cell class and subclass

BCL9L KLF16 ATOH8 POU3F1 MAPK7

2.09e-05159935b4bc888e978b1b577721b891b0af6ba9a1607044
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Pld5|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

POU3F1 FHOD3 ZFPM1 FIGN FMNL1

2.09e-05159935a082e770fa757c4a1d3ed13d53f83297e36faf05
ToppCelldroplet-Lung-LUNG-1m-Lymphocytic-NK_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CITED4 PIM2 CAMK2B ZFPM1 VASP

2.36e-05163935a0315855c354e830e109d41bd6e3396488aa8de9
ToppCelldroplet-Lung-LUNG-1m-Lymphocytic-Natural_Killer|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CITED4 PIM2 CAMK2B ZFPM1 VASP

2.43e-05164935a59078c8f88e416e940c9b15151ce7de1bbe987e
ToppCelldroplet-Liver-Npc|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAP4K1 PPP1R18 NR1D1 FMNL1 VASP

2.88e-0517093509c836840216905d545a25a4fc1bbd0699576c77
ToppCelldroplet-Liver-Npc-18m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAP4K1 PPP1R18 NR1D1 FMNL1 VASP

2.97e-05171935e9c42ce444d42cbb4f97e81393756531bfe61637
ToppCelldroplet-Heart-4Chambers-18m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RUSC1 SOX18 ZFPM1 PRR15 SHANK3

3.14e-051739359a04271c51fae34f547db3206f9ff5857686e45c
ToppCell3'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_B-Branch_B1_(eMN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZNF219 ZFHX2 FMN2 ZNF579 MYO15A

3.22e-05174935271c51d220842402975d97c86c9acfdbdf62a32c
ToppCellfacs-Diaphragm-Limb_Muscle-18m-Endothelial-nan|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CABLES2 SOX18 AFDN FHOD3 SEZ6L2

3.40e-05176935a3f27b5d7edf2d396c085efbe35305cfa0afa565
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATG9B ZFHX2 PRR15 TMEM121 C6orf132

3.40e-0517693587de432c680b80555342afac864599bbc002c040
ToppCell5'-GW_trimst-1.5-SmallIntestine-Hematopoietic-T_cells-Activated_T|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

WAS PIM2 MAP4K1 PPP1R18 FMNL1

3.89e-05181935dd4126bf3c02e63866e2b3f2db81e3565f0e8c40
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CUX2 CAMK2B DAAM2 POU3F1 FIGN

4.10e-051839358330c39184ce076e1f95fd3725b68af551d89db0
ToppCellfacs-Large_Intestine-Distal-3m-Epithelial-enteroendocrine_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAMK2B FMN2 NR1D1 SEZ6L2 FMNL1

4.21e-051849353da93e7d8b62463e307cc0425c47dbd3bef66799
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal-podocyte|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAAM2 POU3F1 DBP FIGN TMEM121

4.32e-05185935ca69499ba8c39b7ed6717d05685d6f70066a77bd
ToppCell5'-GW_trimst-2-SmallIntestine-Hematopoietic-T_cells-Treg|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IRX5 WAS PIM2 PPP1R18 FMNL1

4.43e-051869352a9daf96c2a47f1ed5421130f32f17bd33e644a7
ToppCelldroplet-Heart-HEART-1m-Neuronal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAMK2B POU3F1 FIGN HCN2 TMEM121

4.78e-05189935a618a1ddf5097a010c6c2c7341f3a0bd46a29c02
ToppCelldroplet-Heart-HEART-1m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAMK2B POU3F1 FIGN HCN2 TMEM121

4.78e-051899354e61f9cd1c06bddb47ebf98affc0f97770e26e8c
ToppCell3'-Adult-LargeIntestine-Hematopoietic-T_cells-gdT|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADRB1 WAS MAP4K1 PPP1R18 FMNL1

5.41e-05194935eaa5914009556af99eba80e1925db5c95d3a5b5d
ToppCellfacs-Bladder-nan-3m|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL4A6 SEC23IP DBP SELENON ARAP1

5.68e-0519693544f5b1b474399c9316729155f2ea95a82ca66e30
ToppCellfacs-Bladder-nan-3m-Epithelial|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL4A6 SEC23IP DBP SELENON ARAP1

5.68e-05196935c0e90d964baa2eb4fbd18a52379ccec5d3bf59a8
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-6_mon-Neuronal-PNs|6_mon / Sample Type, Dataset, Time_group, and Cell type.

CUX2 CAMK2B POU3F1 SEZ6L2 FMNL1

5.82e-0519793510e72b425a2bcba35e63a5b074d3dedcd49a762e
ToppCellsaliva-Mild-Moderate_progression_d12-25-Epithelial-Epithelial,_Airway-squamous_epithelial_cell-Epi-Squamous|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

WASL ATG9B AFDN NR1D1 C6orf132

6.10e-05199935667e1a56c33a2681af8dc1b7dbc3a9858e2c3c05
ToppCellsaliva-Mild-Moderate_progression_d12-25-Epithelial-Epithelial,_Airway|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

WASL ATG9B AFDN NR1D1 C6orf132

6.10e-05199935245b37df56dfbbdbac88f0e2fc3dfa0ed1abd588
ToppCellsaliva-Mild-Moderate_progression_d12-25-Epithelial-Epithelial,_Airway-squamous_epithelial_cell|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

WASL ATG9B AFDN NR1D1 C6orf132

6.10e-051999352dae9db4d25f1a390134da2b6621564b274fe910
ToppCelldistal-3-Hematologic|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

WAS PPP1R18 FMNL1 VASP CAP1

6.10e-051999350324eb076ffe6befab03d7a9ea389a94f0644448
ToppCellsaliva-Mild-Moderate_progression_d12-25-Epithelial|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

WASL ATG9B AFDN NR1D1 C6orf132

6.10e-05199935dbb33f0e151b150ba9ca4612973f8034c62e762b
DrugMorantel tartrate [26155-31-7]; Up 200; 10.8uM; PC3; HT_HG-U133A

SETD1A ZNF219 KMT2B PIM2 ZNF335 ZFHX2 IRS2 ARAP1

1.60e-061999387250_UP
DrugC18:1n-7

WASL WAS ATN1 WASF2 WASF3 VASP

2.12e-0692936CID000122325
DrugAC1LD8HW

WAS FMN1 DAAM2 FMNL1 VASP

1.40e-0575935CID000644061
DrugIsoconazole [27523-40-6]; Down 200; 9.6uM; PC3; HT_HG-U133A

ZNF787 PIM2 ATXN2 ZNF335 ARHGAP17 MAPK7 SEZ6L2

1.60e-051969372056_DN
Diseaseright ventricular systolic volume measurement

ATXN2 RBL2 FHOD3 PALLD

4.49e-0635934EFO_0021815
DiseaseIntellectual Disability

SETD1A CUX2 ATN1 CAMK2B ZNF335 SMARCC2 PTPN23 KMT2E SHANK3

1.21e-05447939C3714756
Diseasemean reticulocyte volume

FOXO1 SETD1A KLF16 ATXN2 RNPEPL1 SEC23IP AFDN IRS2 ZFPM1 BAG6 SF1

4.34e-057999311EFO_0010701
DiseaseWiskott-Aldrich syndrome (implicated_via_orthology)

WASL WAS

5.87e-054932DOID:9169 (implicated_via_orthology)
Diseaseprostate cancer (is_marker_for)

FOXO1 KMT2B PIK3R2 MAPK7 KMT2E

1.38e-04156935DOID:10283 (is_marker_for)
Diseasemean arterial pressure, alcohol drinking

CUX2 ADRB1 ATXN2 FIGN

2.66e-0498934EFO_0004329, EFO_0006340
Diseasebody mass index, coronary artery disease

ATXN2 TOMM40

2.72e-048932EFO_0001645, EFO_0004340
Diseaseamnestic disorder (implicated_via_orthology)

IRS1 IRS2

3.49e-049932DOID:10914 (implicated_via_orthology)
Diseasewaist-hip ratio, high density lipoprotein cholesterol measurement

ADRB1 TOMM40

4.35e-0410932EFO_0004343, EFO_0004612
Diseasediastolic blood pressure, alcohol consumption measurement

ADRB1 ATXN2 FIGN

6.69e-0454933EFO_0006336, EFO_0007878
Diseasemean corpuscular hemoglobin concentration

FOXO1 KLF16 WASL CUX2 ATN1 PIM2 ATXN2 RNPEPL1 IRS2 ZFPM1 MYO15A

7.13e-0411059311EFO_0004528
Diseasesystolic blood pressure, alcohol drinking

CUX2 ADRB1 ATXN2 FIGN

7.32e-04128934EFO_0004329, EFO_0006335
Diseasecholesteryl ester measurement, very low density lipoprotein cholesterol measurement

ZDHHC18 ADRB1 ATXN2 TOMM40 DBP

7.43e-04225935EFO_0008317, EFO_0010351
DiseaseGlobal developmental delay

ATN1 ZNF335 SMARCC2 KMT2E

8.45e-04133934C0557874
Diseaseserum non-albumin protein measurement

CUX2 ATXN2 AFDN CNTROB TMEM121 ARAP1

1.00e-03361936EFO_0004568
Diseasebody mass index, high density lipoprotein cholesterol measurement

ATXN2 TOMM40

1.62e-0319932EFO_0004340, EFO_0004612
Diseaseintellectual disability (implicated_via_orthology)

RBL2 IRS1 IRS2

1.74e-0375933DOID:1059 (implicated_via_orthology)
Diseasered blood cell density measurement

FOXO1 ZNF219 UNCX ATXN2 FMN1 RNPEPL1 AFDN IRS2 MYO15A

1.84e-03880939EFO_0007978
Diseasealcohol drinking

CUX2 NAA30 KMT2E

2.16e-0381933EFO_0004329
Diseaseosteoporosis (biomarker_via_orthology)

IRS1 IRS2

2.18e-0322932DOID:11476 (biomarker_via_orthology)
Diseaseplatelet component distribution width

ADRB1 WAS ATXN2 RNPEPL1 WASF3 IRS1 IRS2 ZFPM1

2.67e-03755938EFO_0007984
Diseasehypertension

CUX2 ADRB1 ATXN2 FIGN BAG6

2.91e-03307935EFO_0000537

Protein segments in the cluster

PeptideGeneStartEntry
SPSPAPGAPPPPPQR

AFDN

1696

P55196
SPSPVPAPAPPPGPP

ADRB1

276

P08588
LPGPPGPPGPPSPEF

COL4A6

431

Q14031
PPPHVSSPQPTPPGP

ENKD1

176

Q9H0I2
PAPGGPAQPPPTPQP

BAG6

586

P46379
PSLPPPPAAPASGPP

ATN1

706

P54259
PASFPPPAIPPPTPG

CCNK

491

O75909
PSGPSAGSCPPPPPP

CAP1

221

Q01518
PPPPGPEDPLSPSPG

CUX2

446

O14529
PPGPLPPSLPPVTGP

RBM26

366

Q5T8P6
PNSPAPPNPGGPPPA

FMN1

931

Q68DA7
PGGPSVIHSPPPPPP

IRX5

311

P78411
PSPAPSPGPGPVPPR

PTPN23

1086

Q9H3S7
MPSGGDQSPPPPPPP

RBL2

1

Q08999
PPPPPAPQSQAPGGP

ATOH8

126

Q96SQ7
PPGGPPTPPGAPPCL

DAAM2

561

Q86T65
PACPPPGPAPHPTGP

MAPK7

631

Q13164
PGPAPHPTGPPGPIP

MAPK7

636

Q13164
HPTGPPGPIPVPAPP

MAPK7

641

Q13164
SSGLLQPPPPPPPPP

FIGN

216

Q5HY92
ASPGTPGPPPPPPAA

KLF16

51

Q9BXK1
PGSPLPGSPRPPSPP

MYO15A

836

Q9UKN7
APGPYPSAAPPPPGP

ATXN2

46

Q99700
PSAAPPPPGPGPPPS

ATXN2

51

Q99700
PPPGPGPPPSRQSSP

ATXN2

56

Q99700
PGFPPPPGAPPPSLI

FIP1L1

391

Q6UN15
NSPPPLPPPTSPGGP

ZFPM1

51

Q8IX07
PGPPGPAAPPAPSPA

ZFPM1

721

Q8IX07
LGPEPQEPPPGPPPS

ZFPM1

921

Q8IX07
GGGASPPSAPPPPPP

POU3F1

421

Q03052
PPPPPPPPSSVLASG

KMT2E

1716

Q8IZD2
PPPLPPPSPPGSGRG

ACBD3

36

Q9H3P7
GELAPPGPAPSPPPP

KMT2B

1956

Q9UMN6
PPPPTLPPSSPTNPG

HOXD3

121

P31249
PPPPPPPHQPLGSGE

IRS1

1201

P35568
SQEGPPGLPPQPPPP

NUTM1

151

Q86Y26
PPPPQHGGPPVTAPP

CBLL1

406

Q75N03
LPPPPPPLPSPGQAS

PALLD

821

Q8WX93
QAPSLPPGPPPGPAP

MYO15B

746

Q96JP2
PPGPPPGPAPTLPSR

MYO15B

751

Q96JP2
RAPPPPSSPPPGGAP

PIK3R2

256

O00459
SGSYPPPPGPHPPLP

IRS2

456

Q9Y4H2
TPGPMGPSPPPAPVP

NR1D1

246

P20393
PPPPGPAPGPPQDIS

C6orf132

141

Q5T0Z8
GCLHPAPPQPPPPGP

FOXO1

116

Q12778
SPGAQPAPPPGPLPP

COQ10A

26

Q96MF6
APGPPPPPPPTFLGL

FHOD3

826

Q2V2M9
AGTPQSQPPPLPPPP

BCL9L

296

Q86UU0
PLPPPPPPSCRGPGG

ATG9B

31

Q674R7
APPQAPPLPGSPEPP

FMNL1

561

O95466
HGLPPSPPPPGGPSP

DBP

126

Q10586
SPPPPGGPSPEPSPA

DBP

131

Q10586
PPPGPPPAPYLTPGL

FIGNL2

221

A6NMB9
GIPPAPAPPLPPPGT

FMN2

1216

Q9NZ56
LSPPPPAPTAPQPPG

PPP1R18

431

Q6NYC8
PPPGPAPAAASPGPP

HCN2

761

Q9UL51
SPGPPPPASPPGAPA

HCN2

771

Q9UL51
PPSLGPGGEKPPPPP

CABLES2

61

Q9BTV7
PPSPPGAPSPPEPGG

RING1

246

Q06587
TLPPPNPPAPPAGPS

CNTROB

571

Q8N137
PRASPPPQGPLPGPP

OTUD5

61

Q96G74
QPAPGEPTPPAPPSP

PRR15

36

Q8IV56
PPGPPAPFPPSGPSC

MAPK1IP1L

81

Q8NDC0
PPPGGPYPAPTVPGP

MAPK1IP1L

96

Q8NDC0
GPPPNSPRPGPPPST

MAP4K1

431

Q92918
LPLGPPQAPAPPGPP

RUSC1

671

Q9BVN2
GPPPCPSPTIPGPLP

CAMK2B

516

Q13554
FSAPGPGPAPPPPLP

RNPEPL1

106

Q9HAU8
PPPPPPPPQGGSQLG

TMEM121B

541

Q9BXQ6
PAPAPPKPGNPPPGH

ARHGAP17

636

Q68EM7
LQGPPAPPGTPTPPP

PIM2

6

Q9P1W9
TPGPPAHPPPSGPPV

SEC23IP

206

Q9Y6Y8
PPGTTAPPPPSPASP

SEZ6L2

126

Q6UXD5
APPPPSPASPGPPLG

SEZ6L2

131

Q6UXD5
GGSPPPAPTPPQQPP

SETD1A

591

O15047
VPPGVPPPGPHGPSP

SMARCC2

1036

Q8TAQ2
STLPQGPPQPPSPPP

ARAP1

196

Q96P48
PGPQPAPSAAAPPPP

CITED4

111

Q96RK1
PCAPPPPPPASSPQG

C11orf87

161

Q6NUJ2
APPGSGPGPTPTPPP

SFPQ

141

P23246
PPGAPPPTPPSSGVP

SFPQ

161

P23246
PPAPPPSAPSGPAPA

ZBTB45

341

Q96K62
GPPPPPGATPTSPPE

ZFHX2

616

Q9C0A1
DSGPPPAFSPPPPPG

SHANK3

831

Q9BYB0
QPSPLPPKPPFPGPG

STPG1

256

Q5TH74
NSVPPPPPPLHGPPG

TMEM121

291

Q9BTD3
PPSPGPAAQPPAPPR

SELENON

11

Q9NZV5
TSPGPPPMGPPPPSS

SRA1

56

Q9HD15
PPPPPGPPGPGSSLS

WASF3

401

Q9UPY6
GPPPPPPPATGRSGP

WAS

366

P42768
PPPATGRSGPLPPPP

WAS

371

P42768
PPPPSSGNGPAPPPL

WAS

401

P42768
PPAPPLGSPPGPKPG

WASF2

301

Q9Y6W5
PPPVGFGSPGTPPPP

WASF2

336

Q9Y6W5
PPLSQPTGGAPPPPP

WASF2

381

Q9Y6W5
AASSPPAGPPPPPAP

TOMM40

6

O96008
GPYPGPLSPPPEAPP

SOX18

291

P35713
PPPALPSSAPSGPPP

WASL

346

O00401
PSSAPSGPPPPPPSV

WASL

351

O00401
GPPPSSPGPPEIPPE

ZNF335

741

Q9H4Z2
PPSPGTPPQSPPAPP

ZNF579

511

Q8NAF0
SGQPPPPPSGPLPPW

SF1

486

Q15637
GSFPPPVPPPGALPP

SF3B4

241

Q15427
PTPGPGPAPPAAPAP

ZDHHC18

31

Q9NUE0
AGPGPPPEPPPPSQR

ZNF219

556

Q9P2Y4
TAGPAPPPPAPSPRP

UNCX

481

A6NJT0
GPPPPPGLPPSGVPA

VASP

181

P50552
PPPPPPPPALSGYTT

ZIC5

166

Q96T25
SPPQSAPPAGPPPRP

ZNF787

46

Q6DD87
PGPSSLLPPPAPPAP

NAA30

6

Q147X3