Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	translation elongation factor activity	EEF1A1 EEF1A1P5 EEF1A2	1.35e-05	20	47	3	GO:0003746
GeneOntologyMolecularFunction	monoatomic cation channel activity	KCNK3 CACNG2 SCNN1B CACNA1S PKDREJ TMEM87A	1.46e-04	343	47	6	GO:0005261
GeneOntologyMolecularFunction	monoatomic ion channel activity	KCNK3 CACNG2 SCNN1B CACNA1S PKDREJ TMEM87A	6.90e-04	459	47	6	GO:0005216
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	KCNK3 CACNG2 SCNN1B CACNA1S PKDREJ TMEM87A	7.38e-04	465	47	6	GO:0046873
GeneOntologyMolecularFunction	translation factor activity, RNA binding	EEF1A1 EEF1A1P5 EEF1A2	1.05e-03	85	47	3	GO:0008135
GeneOntologyMolecularFunction	gated channel activity	KCNK3 CACNG2 SCNN1B CACNA1S TMEM87A	1.10e-03	334	47	5	GO:0022836
GeneOntologyMolecularFunction	nitric-oxide synthase binding	CTNNB1 CAV3	1.22e-03	22	47	2	GO:0050998
GeneOntologyMolecularFunction	C-C chemokine receptor activity	CCR4 CCR9	1.33e-03	23	47	2	GO:0016493
GeneOntologyMolecularFunction	channel activity	KCNK3 CACNG2 SCNN1B CACNA1S PKDREJ TMEM87A	1.38e-03	525	47	6	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	KCNK3 CACNG2 SCNN1B CACNA1S PKDREJ TMEM87A	1.39e-03	526	47	6	GO:0022803
GeneOntologyMolecularFunction	C-C chemokine binding	CCR4 CCR9	1.45e-03	24	47	2	GO:0019957
GeneOntologyMolecularFunction	cytokine receptor activity	CCR4 CCR9 IFNAR1	1.54e-03	97	47	3	GO:0004896
GeneOntologyMolecularFunction	WW domain binding	SCNN1B TP63	1.57e-03	25	47	2	GO:0050699
GeneOntologyMolecularFunction	G protein-coupled chemoattractant receptor activity	CCR4 CCR9	1.70e-03	26	47	2	GO:0001637
GeneOntologyMolecularFunction	chemokine receptor activity	CCR4 CCR9	1.70e-03	26	47	2	GO:0004950
GeneOntologyMolecularFunction	translation regulator activity, nucleic acid binding	EEF1A1 EEF1A1P5 EEF1A2	2.33e-03	112	47	3	GO:0090079
GeneOntologyMolecularFunction	chemokine binding	CCR4 CCR9	2.73e-03	33	47	2	GO:0019956
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	KCNK3 CACNG2 SCNN1B CACNA1S PKDREJ TMEM87A	3.36e-03	627	47	6	GO:0022890
GeneOntologyMolecularFunction	calcium channel activity	CACNG2 CACNA1S PKDREJ	3.47e-03	129	47	3	GO:0005262
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	KCNK3 CACNG2 SCNN1B CACNA1S PKDREJ TMEM87A	4.45e-03	664	47	6	GO:0008324
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	CACNG2 CACNA1S	5.25e-03	46	47	2	GO:0005245
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	CACNG2 CACNA1S PKDREJ	5.39e-03	151	47	3	GO:0015085
GeneOntologyMolecularFunction	voltage-gated monoatomic cation channel activity	KCNK3 CACNG2 CACNA1S	5.49e-03	152	47	3	GO:0022843
GeneOntologyMolecularFunction	cytokine binding	CCR4 CCR9 IFNAR1	6.00e-03	157	47	3	GO:0019955
GeneOntologyMolecularFunction	ionotropic glutamate receptor binding	CACNG2 CTNNB1	6.67e-03	52	47	2	GO:0035255
GeneOntologyMolecularFunction	immune receptor activity	CCR4 CCR9 IFNAR1	6.88e-03	165	47	3	GO:0140375
GeneOntologyBiologicalProcess	detection of mechanical stimulus	CTNNB1 CAV3 PKDREJ TMEM87A	2.34e-05	75	46	4	GO:0050982
GeneOntologyCellularComponent	eukaryotic translation elongation factor 1 complex	EEF1A1 EEF1A2	2.96e-05	4	47	2	GO:0005853
GeneOntologyCellularComponent	cytoplasmic side of lysosomal membrane	EEF1A1 EEF1A2	4.43e-04	14	47	2	GO:0098574
HumanPheno	Abnormal blood monovalent inorganic cation concentration	SCNN1B CACNA1S CTNNB1 CAV3 NR0B1	5.56e-05	154	15	5	HP:0010930
HumanPheno	Adrenocortical abnormality	SCNN1B CACNA1S CTNNB1 NR0B1	5.81e-05	77	15	4	HP:0000849
HumanPheno	Hypokalemia	SCNN1B CACNA1S CTNNB1 CAV3	6.43e-05	79	15	4	HP:0002900
Domain	Transl_elong_EF1A_euk/arc	EEF1A1 EEF1A2	5.42e-06	2	44	2	IPR004539
Domain	Transl_elong_EFTu/EF1A_C	EEF1A1 EEF1A2	1.51e-04	8	44	2	IPR004160
Domain	GTP_EFTU_D3	EEF1A1 EEF1A2	1.51e-04	8	44	2	PF03143
Domain	G_TR_CS	EEF1A1 EEF1A2	1.93e-04	9	44	2	IPR031157
Domain	Transl_elong_EF1A/Init_IF2_C	EEF1A1 EEF1A2	2.41e-04	10	44	2	IPR009001
Domain	G_TR_1	EEF1A1 EEF1A2	4.16e-04	13	44	2	PS00301
Domain	Chemokine_rcpt	CCR4 CCR9	6.37e-04	16	44	2	IPR000355
Domain	EFTu-like_2	EEF1A1 EEF1A2	8.10e-04	18	44	2	IPR004161
Domain	GTP_EFTU_D2	EEF1A1 EEF1A2	8.10e-04	18	44	2	PF03144
Domain	G_TR_2	EEF1A1 EEF1A2	8.10e-04	18	44	2	PS51722
Domain	C_TYPE_LECTIN_1	CLEC9A CLEC17A ATRNL1	8.83e-04	80	44	3	PS00615
Domain	TF_GTP-bd_dom	EEF1A1 EEF1A2	9.04e-04	19	44	2	IPR000795
Domain	Lectin_C	CLEC9A CLEC17A ATRNL1	1.02e-03	84	44	3	PF00059
Domain	CLECT	CLEC9A CLEC17A ATRNL1	1.02e-03	84	44	3	SM00034
Domain	C_TYPE_LECTIN_2	CLEC9A CLEC17A ATRNL1	1.05e-03	85	44	3	PS50041
Domain	C-type_lectin-like	CLEC9A CLEC17A ATRNL1	1.09e-03	86	44	3	IPR001304
Domain	-	CLEC9A CLEC17A ATRNL1	1.54e-03	97	44	3	3.10.100.10
Domain	C-type_lectin-like/link	CLEC9A CLEC17A ATRNL1	1.63e-03	99	44	3	IPR016186
Domain	Transl_B-barrel	EEF1A1 EEF1A2	1.83e-03	27	44	2	IPR009000
Domain	CTDL_fold	CLEC9A CLEC17A ATRNL1	2.04e-03	107	44	3	IPR016187
Domain	SAM_2	TP63 EPHA7	4.61e-03	43	44	2	PF07647
Domain	C-type_lectin_CS	CLEC9A CLEC17A	4.61e-03	43	44	2	IPR018378
Domain	6-blade_b-propeller_TolB-like	WRAP73 APEH	5.26e-03	46	44	2	IPR011042
Pubmed	Ubiquitin-like protein FAT10 promotes renal fibrosis by stabilizing USP7 to prolong CHK1-mediated G2/M arrest in renal tubular epithelial cells.	CTNNB1 CAV3 EEF1A1	4.61e-08	6	47	3	36152057
Pubmed	Assignment of human elongation factor 1alpha genes: EEF1A maps to chromosome 6q14 and EEF1A2 to 20q13.3.	EEF1A1 EEF1A1P5 EEF1A2	1.04e-06	15	47	3	8812466
Pubmed	Caveolin-3 is a direct molecular partner of the Cav1.1 subunit of the skeletal muscle L-type calcium channel.	CACNA1S CAV3	1.79e-06	2	47	2	21262376
Pubmed	eEF1A demonstrates paralog specific effects on HIV-1 reverse transcription efficiency.	EEF1A1 EEF1A2	1.79e-06	2	47	2	30782564
Pubmed	TP63 P2 promoter functional analysis identifies β-catenin as a key regulator of ΔNp63 expression.	CTNNB1 TP63	1.79e-06	2	47	2	21643019
Pubmed	Analysis of the Expression and Subcellular Distribution of eEF1A1 and eEF1A2 mRNAs during Neurodevelopment.	EEF1A1 EEF1A2	1.79e-06	2	47	2	35741005
Pubmed	The role of translation elongation factor eEF1 subunits in neurodevelopmental disorders.	EEF1A1 EEF1A2	1.79e-06	2	47	2	30370994
Pubmed	New insights on the interaction between the isoforms 1 and 2 of human translation elongation factor 1A.	EEF1A1 EEF1A2	1.79e-06	2	47	2	26212729
Pubmed	The expression levels of the translational factors eEF1A 1/2 correlate with cell growth but not apoptosis in hepatocellular carcinoma cell lines with different differentiation grade.	EEF1A1 EEF1A2	1.79e-06	2	47	2	17825975
Pubmed	Dissecting the expression of EEF1A1/2 genes in human prostate cancer cells: the potential of EEF1A2 as a hallmark for prostate transformation and progression.	EEF1A1 EEF1A2	1.79e-06	2	47	2	22095224
Pubmed	Understanding functions of eEF1 translation elongation factors beyond translation. A proteomic approach.	EEF1A1 EEF1A2	1.79e-06	2	47	2	38220433
Pubmed	Structural models of human eEF1A1 and eEF1A2 reveal two distinct surface clusters of sequence variation and potential differences in phosphorylation.	EEF1A1 EEF1A2	1.79e-06	2	47	2	19636410
Pubmed	Functional interaction of the two-pore domain potassium channel TASK-1 and caveolin-3.	KCNK3 CAV3	1.79e-06	2	47	2	28648645
Pubmed	Inhibition of β-catenin dependent WNT signalling upregulates the transcriptional repressor NR0B1 and downregulates markers of an A9 phenotype in human embryonic stem cell-derived dopaminergic neurons: Implications for Parkinson's disease.	CTNNB1 NR0B1	1.79e-06	2	47	2	34941945
Pubmed	Cloning of human and mouse brain cDNAs coding for S1, the second member of the mammalian elongation factor-1 alpha gene family: analysis of a possible evolutionary pathway.	EEF1A1 EEF1A2	1.79e-06	2	47	2	7945283
Pubmed	Spatial transcriptomics in embryonic mouse diaphragm muscle reveals regional gradients and subdomains of developmental gene expression.	CACNA1S CTNNB1	1.79e-06	2	47	2	38883818
Pubmed	Dimethylation of eEF1A at Lysine 55 Plays a Key Role in the Regulation of eEF1A2 on Malignant Cell Functions of Acute Myeloid Leukemia.	EEF1A1 EEF1A2	1.79e-06	2	47	2	32347192
Pubmed	Wnt signaling in hepatocellular carcinoma: analysis of mutation and expression of beta-catenin, T-cell factor-4 and glycogen synthase kinase 3-beta genes.	CTNNB1 FKBP4	5.36e-06	3	47	2	12603528
Pubmed	Interaction of elongation factor 1-alpha with leucine-rich repeat kinase 2 impairs kinase activity and microtubule bundling in vitro.	EEF1A1 EEF1A2	5.36e-06	3	47	2	19559761
Pubmed	Aberrant expression of β-catenin and its association with ΔNp63, Notch-1, and clinicopathological factors in oral squamous cell carcinoma.	CTNNB1 TP63	5.36e-06	3	47	2	21881870
Pubmed	DAX1 promotes cervical cancer cell growth and tumorigenicity through activation of Wnt/β-catenin pathway via GSK3β.	CTNNB1 NR0B1	5.36e-06	3	47	2	29497051
Pubmed	Endogenous epitope tagging of eEF1A2 in mice reveals early embryonic expression of eEF1A2 and subcellular compartmentalisation of neuronal eEF1A1 and eEF1A2.	EEF1A1 EEF1A2	5.36e-06	3	47	2	37429391
Pubmed	β-Catenin is required for T-cell leukemia initiation and MYC transcription downstream of Notch1.	CTNNB1 EEF1A1	5.36e-06	3	47	2	27125305
Pubmed	Interplay between CXCR4 and CCR2 regulates bone marrow exit of dendritic cell progenitors.	CLEC9A IFNAR1	5.36e-06	3	47	2	37523265
Pubmed	p63-Mediated activation of the β-catenin/c-Myc signaling pathway stimulates esophageal squamous carcinoma cell invasion and metastasis.	CTNNB1 TP63	5.36e-06	3	47	2	25045846
Pubmed	The nucleocapsid protein of severe acute respiratory syndrome coronavirus inhibits cell cytokinesis and proliferation by interacting with translation elongation factor 1alpha.	EEF1A1 EEF1A2	5.36e-06	3	47	2	18448518
Pubmed	Expression of beta-catenin, p63 and CD34 in hair follicles during the course of androgenetic alopecia.	CTNNB1 TP63	5.36e-06	3	47	2	16133456
Pubmed	Characterization of elongation factor-1A (eEF1A-1) and eEF1A-2/S1 protein expression in normal and wasted mice.	EEF1A1 EEF1A2	1.07e-05	4	47	2	11294870
Pubmed	Inhibition of β-catenin signalling in dermal fibroblasts enhances hair follicle regeneration during wound healing.	CTNNB1 LRIG1	1.07e-05	4	47	2	27287810
Pubmed	Identification of regulators of chaperone-mediated autophagy.	EEF1A1 EEF1A2	1.07e-05	4	47	2	20797626
Pubmed	Glycogen synthase kinase-3beta regulates DeltaNp63 gene transcription through the beta-catenin signaling pathway.	CTNNB1 TP63	1.07e-05	4	47	2	18615589
Pubmed	Dax-1 (dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1) gene transcription is regulated by wnt4 in the female developing gonad.	CTNNB1 NR0B1	1.07e-05	4	47	2	12554773
Pubmed	C-terminal α Domain of p63 Binds to p300 to Coactivate β-Catenin.	CTNNB1 TP63	1.07e-05	4	47	2	30986748
Pubmed	The role of p63 in embryonic external genitalia outgrowth in mice.	CTNNB1 TP63	1.07e-05	4	47	2	36680528
Pubmed	Immuno-characterization of the switch of peptide elongation factors eEF1A-1/EF-1alpha and eEF1A-2/S1 in the central nervous system during mouse development.	EEF1A1 EEF1A2	1.07e-05	4	47	2	15013623
Pubmed	SPECC1L regulates palate development downstream of IRF6.	CTNNB1 TP63	1.78e-05	5	47	2	31943082
Pubmed	Deconstructing Olfactory Stem Cell Trajectories at Single-Cell Resolution.	CTNNB1 TP63	1.78e-05	5	47	2	28506465
Pubmed	The human Y-encoded testis-specific protein interacts functionally with eukaryotic translation elongation factor eEF1A, a putative oncoprotein.	EEF1A1 EEF1A2	1.78e-05	5	47	2	18649364
Pubmed	In-frame deletion of SPECC1L microtubule association domain results in gain-of-function phenotypes affecting embryonic tissue movement and fusion events.	CTNNB1 TP63	1.78e-05	5	47	2	34302166
Pubmed	Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA.	EEF1A1 EEF1A2	1.78e-05	5	47	2	8626763
Pubmed	Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer.	PAAF1 EEF1A1 EEF1A1P5 EEF1A2	1.88e-05	116	47	4	30652415
Pubmed	Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms.	CTNNB1 PKDREJ EEF1A1 EEF1A1P5 EEF1A2	2.48e-05	256	47	5	24189400
Pubmed	Two-photon live imaging of single corneal stem cells reveals compartmentalized organization of the limbal niche.	LRIG1 TP63	2.67e-05	6	47	2	33984283
Pubmed	Type I interferon activates MHC class I-dressed CD11b+ conventional dendritic cells to promote protective anti-tumor CD8+ T cell immunity.	CLEC9A IFNAR1	2.67e-05	6	47	2	34800368
Pubmed	Mouse translation elongation factor eEF1A-2 interacts with Prdx-I to protect cells against apoptotic death induced by oxidative stress.	EEF1A1 EEF1A2	2.67e-05	6	47	2	16888816
Pubmed	Amphiphysin (BIN1) negatively regulates dynamin 2 for normal muscle maturation.	CACNA1S CAV3	3.74e-05	7	47	2	29130937
Pubmed	Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages.	CTNNB1 LRIG1	3.74e-05	7	47	2	26837596
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	KCNK3 CACNG2 SCNN1B CACNA1S	3.81e-05	139	47	4	16985003
Pubmed	Cell type-specific expression of adenomatous polyposis coli in lung development, injury, and repair.	CTNNB1 TP63	4.98e-05	8	47	2	20658693
Pubmed	YB-1 is important for an early stage embryonic development: neural tube formation and cell proliferation.	EEF1A1 EEF1A2	4.98e-05	8	47	2	17082189
Pubmed	Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice.	CLEC9A IFNAR1	4.98e-05	8	47	2	33469015
Pubmed	FBXO11 promotes ubiquitination of the Snail family of transcription factors in cancer progression and epidermal development.	CTNNB1 TP63	6.40e-05	9	47	2	25827072
Pubmed	β-Catenin signaling is essential for mammalian larynx recanalization and the establishment of vocal fold progenitor cells.	CTNNB1 TP63	6.40e-05	9	47	2	29386246
Pubmed	Local lung hypoxia determines epithelial fate decisions during alveolar regeneration.	CTNNB1 TP63	6.40e-05	9	47	2	28737769
Pubmed	Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation.	CTNNB1 TP63	7.99e-05	10	47	2	15987773
Pubmed	AAV-mediated intramuscular delivery of myotubularin corrects the myotubular myopathy phenotype in targeted murine muscle and suggests a function in plasma membrane homeostasis.	CACNA1S CAV3	7.99e-05	10	47	2	18434328
Pubmed	Wnt/Fgf crosstalk is required for the specification of basal cells in the mouse trachea.	CTNNB1 TP63	9.75e-05	11	47	2	30696710
Pubmed	A role for chromosomal protein HMGN1 in corneal maturation.	CTNNB1 TP63	9.75e-05	11	47	2	16466397
Pubmed	Ex vivo cultures combined with vivo-morpholino induced gene knockdown provide a system to assess the role of WT1 and GATA4 during gonad differentiation.	CTNNB1 NR0B1	9.75e-05	11	47	2	28426816
Pubmed	Beta-catenin (CTNNB1) induces Bmp expression in urogenital sinus epithelium and participates in prostatic bud initiation and patterning.	CTNNB1 TP63	9.75e-05	11	47	2	23396188
Pubmed	Respiratory distress and perinatal lethality in Nedd4-2-deficient mice.	SCNN1B TP63	9.75e-05	11	47	2	21505443
Pubmed	USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1.	RNF123 EEF1A1	9.75e-05	11	47	2	19015242
Pubmed	MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1.	APEH CTNNB1 FKBP4 EEF1A1	1.09e-04	182	47	4	30711629
Pubmed	Identification of potential bladder progenitor cells in the trigone.	CTNNB1 TP63	1.17e-04	12	47	2	24992712
Pubmed	Interferon-alpha initiates type 1 diabetes in nonobese diabetic mice.	IFNA8 IFNAR1	1.17e-04	12	47	2	18716002
Pubmed	Mutation of the IFNAR-1 receptor binding site of human IFN-alpha2 generates type I IFN competitive antagonists.	IFNA8 IFNAR1	1.17e-04	12	47	2	18937499
Pubmed	GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on type I interferon signaling.	IFNA8 IFNAR1	1.17e-04	12	47	2	19406830
Pubmed	Suppression of the effector phase of inflammatory arthritis by double-stranded RNA is mediated by type I IFNs.	IFNA8 IFNAR1	1.17e-04	12	47	2	17277125
Pubmed	Podoplanin regulates mammary stem cell function and tumorigenesis by potentiating Wnt/β-catenin signaling.	CTNNB1 TP63	1.17e-04	12	47	2	29361573
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	KNTC1 APEH CACNA1S RNF123 POLD3 PAAF1 FKBP4 EEF1A1 EEF1A2	1.24e-04	1455	47	9	22863883
Pubmed	Insulin receptor substrate-4 interacts with ubiquitin-specific protease 18 to activate the Jak/STAT signaling pathway.	EEF1A1 EEF1A2	1.38e-04	13	47	2	29285303
Pubmed	Stabilized beta-catenin in lung epithelial cells changes cell fate and leads to tracheal and bronchial polyposis.	CTNNB1 TP63	1.38e-04	13	47	2	19631635
Pubmed	Blastocyst complementation reveals that NKX2-1 establishes the proximal-peripheral boundary of the airway epithelium.	CTNNB1 TP63	1.38e-04	13	47	2	33428297
Pubmed	Regional regulation of Filiform tongue papillae development by Ikkα/Irf6.	CTNNB1 TP63	1.38e-04	13	47	2	27302476
Pubmed	Ontogenesis of the tear drainage system requires Prickle1-driven polarized basement membrane deposition.	CTNNB1 TP63	1.38e-04	13	47	2	33144400
Pubmed	Type I IFN protects against antigen-induced arthritis.	IFNA8 IFNAR1	1.38e-04	13	47	2	21469099
Pubmed	Plasmacytoid dendritic cell-derived type I interferon is crucial for the adjuvant activity of Toll-like receptor 7 agonists.	IFNA8 IFNAR1	1.38e-04	13	47	2	20065291
Pubmed	Signal 3 cytokines as modulators of primary immune responses during infections: the interplay of type I IFN and IL-12 in CD8 T cell responses.	IFNA8 IFNAR1	1.61e-04	14	47	2	22815848
Pubmed	Wt1 negatively regulates beta-catenin signaling during testis development.	CTNNB1 NR0B1	1.61e-04	14	47	2	18403409
Pubmed	Regulation of inflammatory monocyte/macrophage recruitment from the bone marrow during murine cytomegalovirus infection: role for type I interferons in localized induction of CCR2 ligands.	IFNA8 IFNAR1	1.61e-04	14	47	2	19620305
Pubmed	Type I IFN enhances follicular B cell contribution to the T cell-independent antibody response.	IFNA8 IFNAR1	1.61e-04	14	47	2	20566717
Pubmed	A structural basis for interferon-alpha-receptor interactions.	IFNA8 IFNAR1	1.61e-04	14	47	2	17517919
Pubmed	B Cell and BAFF dependence of IFN-α-exaggerated disease in systemic lupus erythematosus-prone NZM 2328 mice.	IFNA8 IFNAR1	1.61e-04	14	47	2	21383240
Pubmed	β-catenin is required for prostate development and cooperates with Pten loss to drive invasive carcinoma.	CTNNB1 TP63	1.61e-04	14	47	2	23300485
Pubmed	The histone acetyltransferase inhibitor Nir regulates epidermis development.	CTNNB1 TP63	1.86e-04	15	47	2	29490983
Pubmed	p63 control of desmosome gene expression and adhesion is compromised in AEC syndrome.	CTNNB1 TP63	1.86e-04	15	47	2	23108156
Pubmed	Endogenous IFN-alpha beta suppresses colony-stimulating factor (CSF)-1-stimulated macrophage DNA synthesis and mediates inhibitory effects of lipopolysaccharide and TNF-alpha.	IFNA8 IFNAR1	1.86e-04	15	47	2	8786318
Pubmed	β-Catenin-SOX2 signaling regulates the fate of developing airway epithelium.	CTNNB1 TP63	1.86e-04	15	47	2	22421361
Pubmed	Mutant Lef1 controls Gata6 in sebaceous gland development and cancer.	CTNNB1 LRIG1	2.12e-04	16	47	2	30886049
Pubmed	Aberrant expression of a beta-catenin gain-of-function mutant induces hyperplastic transformation in the mouse cornea.	CTNNB1 TP63	2.12e-04	16	47	2	20332116
Pubmed	Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons.	IFNA8 IFNAR1	2.12e-04	16	47	2	21115688
Pubmed	Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity.	IFNA8 IFNAR1	2.12e-04	16	47	2	16311601
Pubmed	Type I interferon is required for T helper (Th) 2 induction by dendritic cells.	IFNA8 IFNAR1	2.12e-04	16	47	2	28716804
Pubmed	Kif7 regulates Gli2 through Sufu-dependent and -independent functions during skin development and tumorigenesis.	CTNNB1 TP63	2.12e-04	16	47	2	23034632
Pubmed	Epidermal hyperplasia and expansion of the interfollicular stem cell compartment in mutant mice with a C-terminal truncation of Patched1.	CTNNB1 TP63	2.12e-04	16	47	2	17631878
Pubmed	The ciliopathy gene Rpgrip1l is essential for hair follicle development.	CTNNB1 TP63	2.40e-04	17	47	2	25398052
Pubmed	Deletion of Pten expands lung epithelial progenitor pools and confers resistance to airway injury.	CTNNB1 TP63	2.40e-04	17	47	2	19574443
Pubmed	Hedgehog regulation of epithelial cell state and morphogenesis in the larynx.	CTNNB1 TP63	2.40e-04	17	47	2	36398878
Pubmed	Association analysis of 3p21 with Crohn's disease in a New Zealand population.	APEH RNF123	2.40e-04	17	47	2	20307617
Pubmed	Serum response factor controls transcriptional network regulating epidermal function and hair follicle morphogenesis.	CTNNB1 TP63	2.70e-04	18	47	2	23151848
Interaction	FER1L6 interactions	EEF1A1 EEF1A1P5 EEF1A2	3.62e-07	7	45	3	int:FER1L6
Interaction	PRKD2 interactions	PAAF1 FKBP4 EEF1A1 EEF1A1P5 EEF1A2 EPHA7 IFNAR1	1.40e-06	254	45	7	int:PRKD2
Interaction	EEF1AKMT1 interactions	RNF123 EEF1A1 EEF1A2	2.26e-06	12	45	3	int:EEF1AKMT1
Interaction	ADARB2 interactions	EEF1A1 EEF1A1P5 EEF1A2	6.92e-06	17	45	3	int:ADARB2
Interaction	C16orf90 interactions	RNF123 TP63	1.46e-05	3	45	2	int:C16orf90
Interaction	USP8 interactions	SCNN1B POLD3 CTNNB1 LRIG1 TP63	2.48e-05	156	45	5	int:USP8
Interaction	TMEM200C interactions	RNF123 TP63	4.85e-05	5	45	2	int:TMEM200C
Interaction	LIPC interactions	MTMR1 EEF1A1 EEF1A2	5.93e-05	34	45	3	int:LIPC
Cytoband	20q13.3	TCFL5 EEF1A2	1.93e-04	20	47	2	20q13.3
GeneFamily	CD molecules\|C-C motif chemokine receptors	CCR4 CCR9	1.27e-04	10	31	2	1091
GeneFamily	Calcium voltage-gated channel subunits	CACNG2 CACNA1S	9.01e-04	26	31	2	253
GeneFamily	C-type lectin domain family	CLEC9A CLEC17A	2.93e-03	47	31	2	494
CoexpressionAtlas	dev gonad_e12.5_F_VasAssocMesStromOvary_Sma_k-means-cluster#3_top-relative-expression-ranked_200	EPHA7 NR0B1 IFNAR1	6.66e-05	38	44	3	gudmap_dev gonad_e12.5_F_VasAssocMesStromOvary_Sma_k3_200
CoexpressionAtlas	dev gonad_e13.5_M_InterstitFLeydig_MafB_k-means-cluster#1_top-relative-expression-ranked_1000	PLEKHH2 RMDN2 ATRNL1 EPHA7	1.29e-04	125	44	4	gudmap_dev gonad_e13.5_M_InterstitFLeydig_MafB_k1_1000
CoexpressionAtlas	alpha beta T cells, T.4+8int.Th, 4+ 8int TCRhi, Thymus, avg-3	CCR4 GPR174 CCR9	2.13e-04	56	44	3	GSM399362_100
CoexpressionAtlas	dev gonad_e11.5_F_GonadVasMes_Flk_top-relative-expression-ranked_500	PLEKHH2 RMDN2 ATRNL1 EPHA7 NR0B1 IFNAR1	2.24e-04	423	44	6	gudmap_dev gonad_e11.5_F_GonadVasMes_Flk_500
CoexpressionAtlas	dev gonad_e12.5_F_SupCellPrec_Sry_k-means-cluster#1_top-relative-expression-ranked_500	RMDN2 EPHA7 NR0B1 IFNAR1	2.29e-04	145	44	4	gudmap_dev gonad_e12.5_F_SupCellPrec_Sry_k1_500
CoexpressionAtlas	dev gonad_e11.5_F_GonadVasMes_Flk_k-means-cluster#2_top-relative-expression-ranked_500	RMDN2 EPHA7 NR0B1 IFNAR1	2.41e-04	147	44	4	gudmap_dev gonad_e11.5_F_GonadVasMes_Flk_k2_500
CoexpressionAtlas	dev gonad_e12.5_M_InterstitTestis_Sma_k-means-cluster#3_top-relative-expression-ranked_500	RMDN2 EPHA7 NR0B1	2.49e-04	59	44	3	gudmap_dev gonad_e12.5_M_InterstitTestis_Sma_k3_500
CoexpressionAtlas	dev gonad_e11.5_F_GonMes_Sma_top-relative-expression-ranked_500	PLEKHH2 RMDN2 ATRNL1 EPHA7 NR0B1 IFNAR1	2.64e-04	436	44	6	gudmap_dev gonad_e11.5_F_GonMes_Sma_500
CoexpressionAtlas	dev gonad_e12.5_F_VasAssMesen_MafB_top-relative-expression-ranked_200	RMDN2 ATRNL1 EPHA7 NR0B1	2.74e-04	152	44	4	gudmap_dev gonad_e12.5_F_VasAssMesen_MafB_200
CoexpressionAtlas	dev gonad_e11.5_M_GonMes_Sma_top-relative-expression-ranked_1000	CREBRF PLEKHH2 RMDN2 ATRNL1 TIAM2 EPHA7 NR0B1 IFNAR1	3.12e-04	849	44	8	gudmap_dev gonad_e11.5_M_GonMes_Sma_1000
CoexpressionAtlas	dev gonad_e12.5_F_VasAssocMesStromOvary_Sma_top-relative-expression-ranked_200	RMDN2 EPHA7 NR0B1 IFNAR1	3.18e-04	158	44	4	gudmap_dev gonad_e12.5_F_VasAssocMesStromOvary_Sma_200
CoexpressionAtlas	dev gonad_e11.5_F_GonadVasMes_Flk_top-relative-expression-ranked_200	RMDN2 ATRNL1 EPHA7 NR0B1	3.41e-04	161	44	4	gudmap_dev gonad_e11.5_F_GonadVasMes_Flk_200
CoexpressionAtlas	dev gonad_e12.5_F_SupCellPrec_Sry_top-relative-expression-ranked_200	RMDN2 EPHA7 NR0B1 IFNAR1	3.75e-04	165	44	4	gudmap_dev gonad_e12.5_F_SupCellPrec_Sry_200
CoexpressionAtlas	dev gonad_e11.5_F_SupCellPrec_Sry_top-relative-expression-ranked_200	RMDN2 EPHA7 NR0B1 IFNAR1	4.29e-04	171	44	4	gudmap_dev gonad_e11.5_F_SupCellPrec_Sry_200
Disease	developmental and epileptic encephalopathy 33 (implicated_via_orthology)	EEF1A1 EEF1A1P5 EEF1A2	3.55e-09	3	46	3	DOID:0080463 (implicated_via_orthology)
Disease	tumor necrosis factor ligand superfamily member 6, soluble form measurement	APEH RNF123	4.97e-05	7	46	2	EFO_0020797
Disease	hypokalemic periodic paralysis (implicated_via_orthology)	SCNN1B CACNA1S	6.62e-05	8	46	2	DOID:14452 (implicated_via_orthology)
Disease	dilated cardiomyopathy (implicated_via_orthology)	EEF1A1 EEF1A1P5 EEF1A2	2.68e-04	80	46	3	DOID:12930 (implicated_via_orthology)
Disease	Multiple congenital anomalies	CTNNB1 TP63	3.19e-04	17	46	2	C0000772
Disease	cervical cancer	CTNNB1 TP63	1.29e-03	34	46	2	C4048328

Protein segments in the cluster

Peptide	Gene	Start	Entry
KSETNSYLLLKFWTC	ARMH2	161	H3BNL8
SYLLLKFWTCYVLSV	ARMH2	166	H3BNL8
WDTYCEDLTKYTKLT	CREBRF	91	Q8IUR6
YCKTKYSLNSTTWKV	CCR4	186	P51679
SLAWQVKCLLKYSTT	DCAF16	51	Q9NXF7
KEDVYTKTISLWSYI	MTMR1	551	Q13613
WYSSVYTPKILVTCI	OR9G1	71	Q8NH87
DYWLYSRGVCKTKSV	CACNG2	31	Q9Y698
YTYEKLLWTTSRVLK	CTNNB1	331	P35222
DSLVYTWSCKRISTY	NT5DC1	391	Q5TFE4
YSESNKAIYCLWTLT	LINS1	181	Q8NG48
WVCIIYQTRKKSEEY	LRIG1	811	Q96JA1
SCLWYKSREKLQYSI	KCNK3	311	O14649
TTYCLKVKAALLTSW	IFNAR1	196	P17181
VVNYCLKAQWITYET	KNTC1	471	P50748
VLYCTWKTVLSLQDK	GPR174	201	Q9BXC1
YYKKCWSIIENLAIF	EPHA7	201	Q15375
SKRVWCTLIGKTLYY	PLEKHH2	826	Q8IVE3
YKVATWEKQIYTCCR	PAAF1	366	Q9BRP4
SKCWSLNISTKEYAY	NR0B1	366	P51843
TWTYSTELKKLYCQI	TP63	191	Q9H3D4
FKITKYWTSLSNLVA	CACNA1S	536	Q13698
SLWKFETTKYYITII	EEF1A2	76	Q05639
SLWKFETSKYYVTII	EEF1A1	76	P68104
NSLVILVYWYCTRVK	CCR9	66	P51686
LYKYEVNTKTWTILK	ATRNL1	501	Q5VV63
TVSKYWCYRLLSTLL	CAV3	66	P56539
ILCGLWLDYTKTYKQ	FLVCR1	386	Q9Y5Y0
WLDYTKTYKQTTLIV	FLVCR1	391	Q9Y5Y0
SLWKFETSKYYVTII	EEF1A1P5	76	Q5VTE0
TLYLTEKKYSSCAWE	IFNA8	151	P32881
LQYKKIVSWLEYESS	FKBP4	291	Q02790
TYKELLVWYCDNTNT	SCNN1B	21	P51168
SKKTAWILGVYCRTY	TRIM34	356	Q9BYJ4
NLSWSTKYKYTEIRL	PKDREJ	1646	Q9NTG1
RYCWIILYTKETLNS	SHOC1	951	Q5VXU9
LYISDYCVWIQKVKS	SHQ1	381	Q6PI26
RYCYTVSKLSWIEKK	RMDN2	311	Q96LZ7
ITVWSLCTKSVSYIK	WRAP73	116	Q9P2S5
DQNKIVTYKWLSYTL	POLD3	16	Q15054
LCLYDWYTKVTSVVV	APEH	331	P13798
TWKYFICEKYALRSS	CLEC9A	226	Q6UXN8
DLSCYKTTYWICERK	CLEC17A	361	Q6ZS10
KQYWVTLKGCTLLFY	TIAM2	536	Q8IVF5
STTCVYKGKWLYEVL	RNF123	126	Q5XPI4
WEKTSCSKQVTFLVY	ZFAND4	131	Q86XD8
KATTLQWTTAFLKYI	TCFL5	436	Q9UL49
LSLNITWYLKSADCY	TMEM87A	76	Q8NBN3
CYEKISWKTFLKYSE	THOC1	251	Q96FV9