Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhistone reader activity

HDGFL2 MECP2

3.37e-0426212GO:0140566
GeneOntologyMolecularFunctionchromatin-protein adaptor activity

HDGFL2 MECP2

8.43e-0441212GO:0140463
GeneOntologyCellularComponentU2-type spliceosomal complex

BUD13 RBM8A RNF113A

1.04e-0497203GO:0005684
GeneOntologyCellularComponentspliceosomal complex

BUD13 RBM8A RNF113A

1.07e-03215203GO:0005681
GeneOntologyCellularComponentU2-type precatalytic spliceosome

BUD13 RNF113A

1.08e-0351202GO:0071005
GeneOntologyCellularComponentprecatalytic spliceosome

BUD13 RNF113A

1.21e-0354202GO:0071011
GeneOntologyCellularComponentnuclear body

STAG1 CHD3 RBM8A RNF113A DYRK3

1.34e-03903205GO:0016604
GeneOntologyCellularComponentchromatin

STAG1 LBX2 BAZ2B MECP2 CHD3 FOXL1

2.04e-031480206GO:0000785
HumanPhenoTooth malposition

STAG1 SCUBE3 IL11RA MECP2 CHD3 RNF113A

7.16e-0641886HP:0000692
Domain-

BAZ2B MECP2

3.36e-0582123.30.890.10
DomainMethyl_CpG_DNA-bd

BAZ2B MECP2

6.58e-0511212IPR001739
DomainMBD

BAZ2B MECP2

6.58e-0511212PF01429
DomainMBD

BAZ2B MECP2

6.58e-0511212SM00391
DomainMBD

BAZ2B MECP2

6.58e-0511212PS50982
DomainDNA-bd_dom

BAZ2B MECP2

6.58e-0511212IPR016177
DomainAT_hook

PRR12 MECP2

1.43e-0416212PF02178
DomainAT_hook

PRR12 MECP2

4.16e-0427212SM00384
DomainAT_hook_DNA-bd_motif

PRR12 MECP2

4.16e-0427212IPR017956
DomainHMGI/Y_DNA-bd_CS

PRR12 MECP2

5.49e-0431212IPR000637
DomainPHD

BAZ2B CHD3

3.18e-0375212PF00628
DomainZnf_PHD-finger

BAZ2B CHD3

3.52e-0379212IPR019787
DomainPHD

BAZ2B CHD3

4.45e-0389212SM00249
DomainZnf_PHD

BAZ2B CHD3

4.64e-0391212IPR001965
DomainZF_PHD_2

BAZ2B CHD3

5.05e-0395212PS50016
DomainZF_PHD_1

BAZ2B CHD3

5.15e-0396212PS01359
DomainZnf_FYVE_PHD

BAZ2B CHD3

1.17e-02147212IPR011011
Domain-

BAZ2B CHD3 RNF113A

1.33e-024492133.30.40.10
DomainZnf_RING/FYVE/PHD

BAZ2B CHD3 RNF113A

1.41e-02459213IPR013083
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

GTF3C2 PRR12 BAZ2B HDGFL2 MECP2 C19orf53 RCC2 CHD3 RBM8A

2.61e-08129421930804502
Pubmed

Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression.

BUD13 HDGFL2 C19orf53 CHD3

3.53e-085621426919559
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

GTF3C2 STAG1 BAZ2B SCMH1 HDGFL2 MECP2 CHD3

4.53e-0860821736089195
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

BUD13 BAZ2B HDGFL2 MECP2 C19orf53 RCC2 CHD3 RBM8A

4.61e-0895421836373674
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

PRR12 BAZ2B MECP2 C19orf53 RCC2 TWF2 CHD3 RNF113A

1.41e-07110321834189442
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

GTF3C2 PRR12 BUD13 HDGFL2 MECP2 C19orf53 RCC2 RBM8A

1.42e-06149721831527615
Pubmed

SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.

BUD13 HDGFL2 RCC2 RBM8A

1.44e-0525121431076518
Pubmed

Structure of the human activated spliceosome in three conformational states.

BUD13 RNF113A

4.15e-051621229360106
Pubmed

The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain.

GTF3C2 C19orf53 CHD3 RBM8A

1.04e-0441721436537216
Pubmed

Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover.

PRR12 HDGFL2 RBM8A RNF113A

1.12e-0442521424999758
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

GTF3C2 STAG1 MECP2 FOXL1 DRAP1

1.32e-0485721525609649
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

GTF3C2 HDGFL2 MECP2 CHD3

1.63e-0446921427634302
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

STAG1 PRR12 RCC2 DRAP1

1.71e-0447521431040226
Pubmed

Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.

HDGFL2 RCC2 TWF2 RNF113A

2.18e-0450621430890647
Pubmed

Dynamic protein-protein interaction wiring of the human spliceosome.

BUD13 RBM8A RNF113A

2.21e-0419721322365833
Pubmed

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

GTF3C2 SCMH1 MECP2 CHD3

2.65e-0453321430554943
Pubmed

Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.

GTF3C2 MECP2 RCC2 CHD3

2.65e-0453321425544563
Pubmed

Primary Cilia are Required for Cell-Type Determination and Angiogenesis in Pituitary Development.

DYRK3 FOXL1

3.69e-044721239001875
Pubmed

Protein microarray analysis identifies human cellular prion protein interactors.

BAZ2B DYRK3

3.85e-044821218482256
Pubmed

SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.

BUD13 RBM8A RNF113A

4.92e-0425921330404004
Pubmed

Mice lacking DYRK2 exhibit congenital malformations with lung hypoplasia and altered Foxf1 expression gradient.

DYRK3 FOXL1

5.43e-045721234671097
Pubmed

SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.

GTF3C2 RCC2 CHD3 RNF113A

5.78e-0465521435819319
Pubmed

ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.

HDGFL2 RCC2 TWF2 RBM8A

5.95e-0466021432780723
InteractionCEBPA interactions

STAG1 PRR12 BAZ2B HDGFL2 MECP2 C19orf53 RCC2 TWF2 CHD3 RNF113A

1.47e-0712452110int:CEBPA
InteractionH3C3 interactions

GTF3C2 STAG1 BAZ2B SCMH1 HDGFL2 MECP2 CHD3

4.46e-07495217int:H3C3
InteractionH2BC8 interactions

GTF3C2 STAG1 BUD13 HDGFL2 MECP2 RCC2 CHD3

1.23e-06576217int:H2BC8
InteractionLYAR interactions

BUD13 MECP2 TWF2 CHD3 RBM8A RNF113A

1.66e-06373216int:LYAR
InteractionSNRNP70 interactions

GTF3C2 MECP2 C19orf53 RCC2 CHD3 RBM8A RNF113A DRAP1

3.62e-06984218int:SNRNP70
InteractionSMC5 interactions

BUD13 BAZ2B HDGFL2 MECP2 C19orf53 RCC2 CHD3 RBM8A

4.08e-061000218int:SMC5
InteractionRPL13 interactions

GTF3C2 BUD13 HDGFL2 MECP2 CHD3 RBM8A RNF113A

4.50e-06700217int:RPL13
InteractionRPL4 interactions

GTF3C2 BUD13 HDGFL2 MECP2 CHD3 RBM8A RNF113A

7.99e-06764217int:RPL4
InteractionHDGFL3 interactions

BAZ2B HDGFL2 DRAP1

1.64e-0548213int:HDGFL3
InteractionBAZ1A interactions

STAG1 MECP2 CHD3 FOXL1

1.87e-05156214int:BAZ1A
InteractionSF3B1 interactions

STAG1 MECP2 CHD3 RBM8A RNF113A FOXL1

1.90e-05571216int:SF3B1
InteractionYLPM1 interactions

MECP2 CHD3 RBM8A RNF113A

2.06e-05160214int:YLPM1
InteractionMBD2 interactions

STAG1 MECP2 CHD3 RNF113A

2.11e-05161214int:MBD2
InteractionGTF3C5 interactions

GTF3C2 MECP2 RNF113A FOXL1

2.11e-05161214int:GTF3C5
InteractionEWSR1 interactions

PRR12 SCMH1 HDGFL2 MECP2 CHD3 RBM8A RNF113A

2.42e-05906217int:EWSR1
InteractionSNRNP40 interactions

BUD13 BAZ2B HDGFL2 MECP2 RCC2 CHD3

3.52e-05637216int:SNRNP40
InteractionDDX47 interactions

STAG1 MECP2 CHD3 RBM8A

3.72e-05186214int:DDX47
InteractionNOP16 interactions

MECP2 RBM8A RNF113A DRAP1

4.12e-05191214int:NOP16
InteractionMYCN interactions

GTF3C2 STAG1 BUD13 HDGFL2 MECP2 C19orf53 RCC2 RBM8A

4.15e-051373218int:MYCN
InteractionRPLP0 interactions

GTF3C2 BUD13 MECP2 CHD3 RBM8A RNF113A

4.30e-05660216int:RPLP0
InteractionRPL24 interactions

HDGFL2 MECP2 CHD3 RBM8A RNF113A

4.54e-05397215int:RPL24
InteractionRPL7A interactions

BUD13 MECP2 RCC2 CHD3 RBM8A RNF113A

5.03e-05679216int:RPL7A
InteractionSMC3 interactions

STAG1 PRR12 MECP2 CHD3 FOXL1

5.17e-05408215int:SMC3
InteractionCHD6 interactions

MECP2 CHD3 RNF113A

5.32e-0571213int:CHD6
InteractionNOP2 interactions

BUD13 MECP2 CHD3 RBM8A RNF113A

5.67e-05416215int:NOP2
InteractionSMC1A interactions

STAG1 PRR12 MECP2 CHD3 FOXL1

5.80e-05418215int:SMC1A
InteractionFXR2 interactions

BAZ2B SCMH1 MECP2 CHD3 RNF113A

6.63e-05430215int:FXR2
InteractionEIF4G1 interactions

HDGFL2 MECP2 CHD3 RBM8A FOXL1

6.85e-05433215int:EIF4G1
InteractionMTA2 interactions

STAG1 BUD13 MECP2 CHD3 RNF113A

7.00e-05435215int:MTA2
InteractionRPL3 interactions

GTF3C2 BUD13 MECP2 CHD3 RBM8A RNF113A

7.09e-05722216int:RPL3
InteractionRPL22 interactions

HDGFL2 MECP2 CHD3 RBM8A RNF113A

7.39e-05440215int:RPL22
InteractionNLE1 interactions

BUD13 BAZ2B MECP2 CHD3

8.21e-05228214int:NLE1
InteractionH3-3A interactions

GTF3C2 STAG1 SCMH1 HDGFL2 MECP2 CHD3

8.68e-05749216int:H3-3A
InteractionRPL27A interactions

GTF3C2 MECP2 CHD3 RBM8A RNF113A

9.02e-05459215int:RPL27A
InteractionSNRNP200 interactions

STAG1 MECP2 CHD3 RBM8A RNF113A

9.12e-05460215int:SNRNP200
InteractionGTF3C1 interactions

GTF3C2 MECP2 RNF113A FOXL1

1.02e-04241214int:GTF3C1
InteractionLUC7L interactions

GTF3C2 MECP2 CHD3 RNF113A

1.03e-04242214int:LUC7L
InteractionNKRF interactions

MECP2 CHD3 RBM8A RNF113A

1.07e-04244214int:NKRF
InteractionDDX23 interactions

BUD13 HDGFL2 MECP2 CHD3 RNF113A

1.11e-04480215int:DDX23
InteractionRPL10A interactions

BUD13 MECP2 CHD3 RBM8A RNF113A

1.23e-04490215int:RPL10A
InteractionNCL interactions

HDGFL2 MECP2 TWF2 CHD3 RBM8A RNF113A

1.23e-04798216int:NCL
InteractionRPL28 interactions

GTF3C2 BUD13 CHD3 RBM8A RNF113A

1.27e-04494215int:RPL28
InteractionDDX50 interactions

GTF3C2 MECP2 CHD3 RNF113A

1.30e-04257214int:DDX50
InteractionRPL36 interactions

BUD13 MECP2 CHD3 RBM8A RNF113A

1.40e-04504215int:RPL36
InteractionRPL18 interactions

BUD13 MECP2 CHD3 RBM8A RNF113A

1.51e-04512215int:RPL18
InteractionEIF2S1 interactions

MECP2 CHD3 RBM8A DYRK3

1.71e-04276214int:EIF2S1
InteractionRPS14 interactions

BUD13 MECP2 CHD3 RBM8A RNF113A

1.76e-04529215int:RPS14
InteractionRPL15 interactions

GTF3C2 MECP2 CHD3 RBM8A RNF113A

1.77e-04530215int:RPL15
InteractionDDX51 interactions

GTF3C2 MECP2 CHD3

1.86e-04108213int:DDX51
InteractionRPL29 interactions

MECP2 CHD3 RBM8A RNF113A

1.86e-04282214int:RPL29
InteractionMTA1 interactions

STAG1 BUD13 CHD3 RNF113A

1.89e-04283214int:MTA1
InteractionRPL8 interactions

BUD13 MECP2 CHD3 RBM8A RNF113A

1.92e-04539215int:RPL8
InteractionCSNK2A3 interactions

HDGFL2 RCC2 RNF113A

1.96e-04110213int:CSNK2A3
InteractionADAR interactions

STAG1 MECP2 CHD3 FOXL1

1.96e-04286214int:ADAR
InteractionCBX1 interactions

PRR12 HDGFL2 MECP2 CHD3

2.02e-04288214int:CBX1
InteractionZC3H18 interactions

BUD13 MECP2 RCC2 CHD3 RBM8A RNF113A

2.06e-04877216int:ZC3H18
InteractionFLG2 interactions

STAG1 MECP2 CHD3

2.07e-04112213int:FLG2
InteractionHNRNPUL2 interactions

MECP2 CHD3 RNF113A FOXL1

2.10e-04291214int:HNRNPUL2
InteractionTHOC7 interactions

MECP2 CHD3 RBM8A

2.18e-04114213int:THOC7
InteractionRPL14 interactions

BUD13 MECP2 CHD3 RBM8A RNF113A

2.18e-04554215int:RPL14
InteractionMBD3 interactions

STAG1 MECP2 CHD3 RNF113A

2.21e-04295214int:MBD3
InteractionBRIX1 interactions

MECP2 CHD3 RBM8A RNF113A

2.36e-04300214int:BRIX1
InteractionACIN1 interactions

MECP2 CHD3 RBM8A RNF113A

2.39e-04301214int:ACIN1
InteractionH3C1 interactions

GTF3C2 STAG1 HDGFL2 MECP2 RCC2 CHD3

2.39e-04901216int:H3C1
InteractionSAP18 interactions

MECP2 CHD3 RBM8A RNF113A

2.51e-04305214int:SAP18
InteractionUSP7 interactions

LBX2 PRR12 MECP2 RCC2 RNF113A DYRK3 FOXL1

2.53e-041313217int:USP7
InteractionRRP1B interactions

MECP2 CHD3 RBM8A RNF113A

2.81e-04314214int:RRP1B
InteractionNOP9 interactions

MECP2 RBM8A FOXL1

2.86e-04125213int:NOP9
InteractionSART1 interactions

MECP2 CHD3 RBM8A RNF113A

2.91e-04317214int:SART1
InteractionRPS12 interactions

MECP2 CHD3 RBM8A RNF113A

3.05e-04321214int:RPS12
InteractionFKBP11 interactions

HDGFL2 MECP2

3.06e-0425212int:FKBP11
InteractionTSR1 interactions

HDGFL2 MECP2 CHD3 RBM8A

3.09e-04322214int:TSR1
InteractionRBM25 interactions

MECP2 CHD3 RNF113A DRAP1

3.12e-04323214int:RBM25
InteractionRPS17 interactions

MECP2 CHD3 RBM8A RNF113A

3.67e-04337214int:RPS17
InteractionNAA40 interactions

HDGFL2 MECP2 RCC2 CHD3 RNF113A FOXL1

3.72e-04978216int:NAA40
InteractionNUP43 interactions

BUD13 BAZ2B MECP2 RCC2 CHD3

3.80e-04625215int:NUP43
InteractionSMARCA2 interactions

HDGFL2 MECP2 CHD3 DRAP1

4.06e-04346214int:SMARCA2
InteractionSRRM1 interactions

MECP2 CHD3 RBM8A RNF113A

4.15e-04348214int:SRRM1
InteractionRPL19 interactions

BUD13 CHD3 RBM8A RNF113A DRAP1

4.18e-04638215int:RPL19
InteractionTRPS1 interactions

CHD3 RNF113A FOXL1

4.24e-04143213int:TRPS1
InteractionSMARCC2 interactions

HDGFL2 MECP2 CHD3 DRAP1

4.37e-04353214int:SMARCC2
InteractionLUC7L2 interactions

MECP2 CHD3 RBM8A RNF113A

4.37e-04353214int:LUC7L2
InteractionZBTB38 interactions

GTF3C2 MECP2 RCC2

4.41e-04145213int:ZBTB38
InteractionEIF4A1 interactions

MECP2 RCC2 CHD3 RBM8A

4.47e-04355214int:EIF4A1
InteractionRPL11 interactions

BUD13 MECP2 CHD3 RBM8A RNF113A

4.62e-04652215int:RPL11
InteractionRPS2 interactions

GTF3C2 MECP2 CHD3 RBM8A RNF113A

4.78e-04657215int:RPS2
InteractionDHX9 interactions

MECP2 TWF2 CHD3 RBM8A RNF113A

4.95e-04662215int:DHX9
InteractionRBM28 interactions

MECP2 CHD3 RBM8A RNF113A

5.12e-04368214int:RBM28
InteractionPUF60 interactions

MECP2 CHD3 RNF113A FOXL1

5.17e-04369214int:PUF60
InteractionGSE1 interactions

CHD3 RNF113A FOXL1

5.26e-04154213int:GSE1
InteractionRPS23 interactions

MECP2 CHD3 RBM8A RNF113A

5.39e-04373214int:RPS23
InteractionRPL31 interactions

BUD13 C19orf53 CHD3 RBM8A RNF113A

5.59e-04680215int:RPL31
InteractionCENPA interactions

GTF3C2 HDGFL2 MECP2 CHD3

5.61e-04377214int:CENPA
InteractionTAF9 interactions

MECP2 FOXL1 DRAP1

5.77e-04159213int:TAF9
InteractionSNRPD3 interactions

MECP2 RCC2 RBM8A RNF113A

5.78e-04380214int:SNRPD3
InteractionSRP68 interactions

MECP2 CHD3 RBM8A RNF113A

5.83e-04381214int:SRP68
InteractionSMARCC1 interactions

HDGFL2 MECP2 CHD3 DRAP1

6.01e-04384214int:SMARCC1
InteractionRNF113A interactions

GTF3C2 RCC2 CHD3 RBM8A RNF113A

6.06e-04692215int:RNF113A
InteractionGNL2 interactions

MECP2 CHD3 RBM8A RNF113A

6.13e-04386214int:GNL2
InteractionACTC1 interactions

HDGFL2 RCC2 TWF2 CHD3 RNF113A

6.14e-04694215int:ACTC1
GeneFamilyZinc fingers CXXC-type|Methyl-CpG binding domain containing

BAZ2B MECP2

1.85e-05111121025
GeneFamilyPHD finger proteins

BAZ2B CHD3

1.31e-039011288
CoexpressionGSE41978_WT_VS_ID2_KO_AND_BIM_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_UP

STAG1 BUD13 MECP2 C19orf53

1.78e-05200214M9550
DiseaseIntellectual Disability

STAG1 PRR12 MECP2 CHD3 RNF113A

7.61e-06447195C3714756
Diseasetriacylglycerol 51:2 measurement

GTF3C2 BUD13

1.10e-058192EFO_0021483
Diseasesleep duration, triglyceride measurement

GTF3C2 STAG1 BUD13

3.96e-05104193EFO_0004530, EFO_0005271
Diseasetriacylglycerol 52:2 measurement

GTF3C2 BUD13

5.72e-0455192EFO_0010414
Diseasedentures

STAG1 FOXL1

9.24e-0470192EFO_0010078
Diseasedental caries, dentures

STAG1 FOXL1

9.24e-0470192EFO_0003819, EFO_0010078
Diseasefeeling nervous measurement

STAG1 TWF2

1.42e-0387192EFO_0009597
Diseasecoronary artery disease, factor VII measurement

STAG1 BUD13

2.30e-03111192EFO_0001645, EFO_0004619
Diseasebilirubin measurement

STAG1 HDGFL2 CHD3

2.71e-03442193EFO_0004570
Diseasesleep duration, high density lipoprotein cholesterol measurement

STAG1 BUD13

2.72e-03121192EFO_0004612, EFO_0005271
DiseaseGlobal developmental delay

PRR12 CHD3

3.28e-03133192C0557874
DiseaseMental Retardation, Psychosocial

STAG1 MECP2

3.57e-03139192C0025363
DiseaseProfound Mental Retardation

STAG1 MECP2

3.57e-03139192C0020796
DiseaseMental deficiency

STAG1 MECP2

3.57e-03139192C0917816

Protein segments in the cluster

PeptideGeneStartEntry
GRKRRKKRPKPGGAG

BUD13

31

Q9BRD0
LGTPTPGRKRRRKGG

BAZ2B

1281

Q9UIF8
PPGRKKRWGRRGRGL

CCER1

136

Q8TC90
KGARRGRKPGSGGRK

DRAP1

106

Q14919
ARAGPRKRGGPAGRK

RCC2

21

Q9P258
VRGPPKGKRRGGRRR

RBM8A

151

Q9Y5S9
LRLRRGGKDGSPKPG

IL11RA

391

Q14626
NRGPRKGGRVIAPKK

C19orf53

26

Q9UNZ5
LGPGPFGRKRRKSRT

LBX2

76

Q6XYB7
KPGRKGAAGRRKRPA

RNF113A

21

O15541
VKKRGRKGRGRGPPS

HDGFL2

381

Q7Z4V5
GRPDGPVRTKKLKRG

CHD3

336

Q12873
GNYRRRKRKPKPGPG

FOXL1

136

Q12952
SRKGKGRRARTPPGK

SCUBE3

531

Q8IX30
GGRSRRGKKRGPPGS

DYRK3

466

O43781
RGRGRPKGSGTTRPK

MECP2

186

P51608
GAKKPRGRGRGRGRK

PRR12

1196

Q9ULL5
GQRGRKPGKKRGRTP

SCMH1

271

Q96GD3
VKGKRKRGRPGRPPS

STAG1

31

Q8WVM7
VSKPRASKPGRKRGG

GTF3C2

91

Q8WUA4
ASKPGRKRGGRTRKG

GTF3C2

96

Q8WUA4
RKRGGRTRKGPKRPQ

GTF3C2

101

Q8WUA4
PKGPGGKRGHKRLIR

TWF2

326

Q6IBS0