Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	structural constituent of postsynaptic actin cytoskeleton	ACTBL2 ACTB ACTG1	2.39e-05	11	107	3	GO:0098973
GeneOntologyMolecularFunction	structural constituent of postsynapse	ACTBL2 ACTB ACTG1 DLG2	2.50e-05	32	107	4	GO:0099186
GeneOntologyMolecularFunction	endoribonuclease activity, cleaving miRNA-paired mRNA	AGO2 AGO3	2.84e-05	2	107	2	GO:0090624
GeneOntologyMolecularFunction	structural constituent of synapse	ACTBL2 ACTB ACTG1 DLG2	7.46e-05	42	107	4	GO:0098918
GeneOntologyMolecularFunction	5'-3' RNA exonuclease activity	XRN1 CPSF3	1.69e-04	4	107	2	GO:0004534
GeneOntologyMolecularFunction	cysteine-type deubiquitinase activity	USP50 OTUB2 OTUD4 TNFAIP3 EIF3F	3.71e-04	114	107	5	GO:0004843
GeneOntologyMolecularFunction	deubiquitinase activity	USP50 OTUB2 OTUD4 TNFAIP3 EIF3F	5.46e-04	124	107	5	GO:0101005
GeneOntologyMolecularFunction	ubiquitin-like protein peptidase activity	USP50 OTUB2 OTUD4 TNFAIP3 EIF3F	8.58e-04	137	107	5	GO:0019783
GeneOntologyBiologicalProcess	protein K48-linked deubiquitination	USP50 OTUB2 OTUD4 TNFAIP3	1.73e-05	31	104	4	GO:0071108
GeneOntologyBiologicalProcess	protein K63-linked deubiquitination	USP50 OTUB2 OTUD4 TNFAIP3	1.97e-05	32	104	4	GO:0070536
GeneOntologyCellularComponent	NuA4 histone acetyltransferase complex	ACTBL2 ACTB ACTG1 TRRAP	2.09e-05	32	107	4	GO:0035267
GeneOntologyCellularComponent	H4/H2A histone acetyltransferase complex	ACTBL2 ACTB ACTG1 TRRAP	2.09e-05	32	107	4	GO:0043189
GeneOntologyCellularComponent	cytoplasmic ribonucleoprotein granule	AGO2 ACTB HIPK2 AGO3 CNOT9 RBFOX1 XRN1 AJUBA	7.36e-05	269	107	8	GO:0036464
GeneOntologyCellularComponent	H4 histone acetyltransferase complex	ACTBL2 ACTB ACTG1 TRRAP	8.22e-05	45	107	4	GO:1902562
GeneOntologyCellularComponent	ribonucleoprotein granule	AGO2 ACTB HIPK2 AGO3 CNOT9 RBFOX1 XRN1 AJUBA	1.15e-04	287	107	8	GO:0035770
GeneOntologyCellularComponent	P-body	AGO2 AGO3 CNOT9 XRN1 AJUBA	1.80e-04	102	107	5	GO:0000932
GeneOntologyCellularComponent	dense body	ACTB ACTG1	5.36e-04	7	107	2	GO:0097433
GeneOntologyCellularComponent	actin filament	ACTBL2 ACTB ACTG1 SPECC1L SPECC1	9.32e-04	146	107	5	GO:0005884
GeneOntologyCellularComponent	filamentous actin	ACTG1 SPECC1L SPECC1	9.66e-04	38	107	3	GO:0031941
GeneOntologyCellularComponent	RISC-loading complex	AGO2 AGO3	1.14e-03	10	107	2	GO:0070578
GeneOntologyCellularComponent	histone acetyltransferase complex	ACTBL2 ACTB ACTG1 TRRAP	1.39e-03	94	107	4	GO:0000123
GeneOntologyCellularComponent	juxtaparanode region of axon	CNTNAP2 DLG2	1.66e-03	12	107	2	GO:0044224
Domain	ACTINS_1	ACTBL2 ACTB ACTG1	9.47e-06	8	105	3	PS00406
Domain	OTU	OTUB2 OTUD4 TNFAIP3	7.48e-05	15	105	3	PS50802
Domain	OTU_dom	OTUB2 OTUD4 TNFAIP3	7.48e-05	15	105	3	IPR003323
Domain	Actin_CS	ACTBL2 ACTB ACTG1	9.17e-05	16	105	3	IPR004001
Domain	ACTINS_2	ACTBL2 ACTB ACTG1	1.11e-04	17	105	3	PS00432
Domain	Actin/actin-like_CS	ACTBL2 ACTB ACTG1	1.32e-04	18	105	3	IPR020902
Domain	ACTINS_ACT_LIKE	ACTBL2 ACTB ACTG1	1.57e-04	19	105	3	PS01132
Domain	Argonaute_N	AGO2 AGO3	1.86e-04	4	105	2	IPR032474
Domain	Argonaute_Mid_dom	AGO2 AGO3	1.86e-04	4	105	2	IPR032473
Domain	ArgoL2	AGO2 AGO3	1.86e-04	4	105	2	IPR032472
Domain	ArgoN	AGO2 AGO3	1.86e-04	4	105	2	PF16486
Domain	ArgoMid	AGO2 AGO3	1.86e-04	4	105	2	PF16487
Domain	ArgoL2	AGO2 AGO3	1.86e-04	4	105	2	PF16488
Domain	DUF1785	AGO2 AGO3	3.10e-04	5	105	2	SM01163
Domain	ArgoL1	AGO2 AGO3	4.63e-04	6	105	2	PF08699
Domain	ArgoL1	AGO2 AGO3	4.63e-04	6	105	2	IPR014811
Domain	Actin	ACTBL2 ACTB ACTG1	6.92e-04	31	105	3	IPR004000
Domain	Actin	ACTBL2 ACTB ACTG1	6.92e-04	31	105	3	PF00022
Domain	ACTIN	ACTBL2 ACTB ACTG1	6.92e-04	31	105	3	SM00268
Domain	PIWI	AGO2 AGO3	8.57e-04	8	105	2	PS50822
Domain	Piwi	AGO2 AGO3	8.57e-04	8	105	2	SM00950
Domain	Piwi	AGO2 AGO3	8.57e-04	8	105	2	PF02171
Domain	Piwi	AGO2 AGO3	8.57e-04	8	105	2	IPR003165
Domain	PAZ	AGO2 AGO3	1.10e-03	9	105	2	PS50821
Domain	PAZ	AGO2 AGO3	1.10e-03	9	105	2	SM00949
Domain	PAZ	AGO2 AGO3	1.10e-03	9	105	2	PF02170
Domain	PAZ_dom	AGO2 AGO3	1.10e-03	9	105	2	IPR003100
Domain	OTU	OTUD4 TNFAIP3	2.35e-03	13	105	2	PF02338
Domain	MS4A	MS4A6E TMEM212	2.73e-03	14	105	2	IPR030417
Domain	Post-SET_dom	NSD3 SETDB1	3.57e-03	16	105	2	IPR003616
Domain	PostSET	NSD3 SETDB1	3.57e-03	16	105	2	SM00508
Domain	POST_SET	NSD3 SETDB1	3.57e-03	16	105	2	PS50868
Domain	LH2	PNLIPRP1 PKD1	4.52e-03	18	105	2	SM00308
Domain	-	PNLIPRP1 PKD1	6.13e-03	21	105	2	2.60.60.20
Domain	PLAT	PNLIPRP1 PKD1	6.13e-03	21	105	2	PF01477
Domain	PLAT/LH2_dom	PNLIPRP1 PKD1	6.13e-03	21	105	2	IPR001024
Domain	FA58C	F5 CNTNAP2	6.13e-03	21	105	2	SM00231
Domain	PLAT	PNLIPRP1 PKD1	6.13e-03	21	105	2	PS50095
Domain	FA58C_3	F5 CNTNAP2	6.13e-03	21	105	2	PS50022
Domain	FA58C_1	F5 CNTNAP2	6.13e-03	21	105	2	PS01285
Domain	FA58C_2	F5 CNTNAP2	6.13e-03	21	105	2	PS01286
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	AGO2 ACTBL2 ACTB ACTG1 CACHD1 ARHGAP39 PTPN21 COLGALT1 NSD3 PTPRB GSE1 OTUD4 AJUBA CPSF3	4.75e-06	1049	108	14	27880917
Pubmed	ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure.	PDS5B AGO2 ACTBL2 SPECC1L RBFOX1 EIF3F EIF2A CPSF3	6.65e-06	315	108	8	26777405
Pubmed	Human transcription factor protein interaction networks.	AGO2 RADX PSMB7 HIPK2 E2F1 ATXN1L TRRAP SETDB1 OTUB2 GSE1 AGO3 CNOT9 NFIC XRN1 OTUD4 EIF3F	8.75e-06	1429	108	16	35140242
Pubmed	Beta and gamma-cytoplasmic actins display distinct distribution and functional diversity.	ACTB ACTG1	9.55e-06	2	108	2	19638415
Pubmed	Beta- and gamma-cytoplasmic actins are required for meiosis in mouse oocytes.	ACTB ACTG1	9.55e-06	2	108	2	21778137
Pubmed	De novo mutations in the actin genes ACTB and ACTG1 cause Baraitser-Winter syndrome.	ACTB ACTG1	9.55e-06	2	108	2	22366783
Pubmed	Botulinum C2 toxin ADP-ribosylates cytoplasmic beta/gamma-actin in arginine 177.	ACTB ACTG1	9.55e-06	2	108	2	3335520
Pubmed	Wolf-Hirschhorn syndrome candidate 1-like 1 epigenetically regulates nephrin gene expression.	NPHS1 NSD3	9.55e-06	2	108	2	28228401
Pubmed	Association of human immunodeficiency virus Nef protein with actin is myristoylation dependent and influences its subcellular localization.	ACTB ACTG1	9.55e-06	2	108	2	9288906
Pubmed	High level expression of transfected beta- and gamma-actin genes differentially impacts on myoblast cytoarchitecture.	ACTB ACTG1	9.55e-06	2	108	2	1577857
Pubmed	Prenatal presentation and diagnosis of Baraitser-Winter syndrome using exome sequencing.	ACTB ACTG1	9.55e-06	2	108	2	32588558
Pubmed	Baraitser-Winter cerebrofrontofacial syndrome.	ACTB ACTG1	9.55e-06	2	108	2	27625340
Pubmed	Homeodomain-interacting protein kinase 2 plays an important role in normal terminal erythroid differentiation.	HIPK1 HIPK2	9.55e-06	2	108	2	20231426
Pubmed	Baraitser-Winter Cerebrofrontofacial Syndrome	ACTB ACTG1	9.55e-06	2	108	2	26583190
Pubmed	Knockout of ACTB and ACTG1 with CRISPR/Cas9(D10A) Technique Shows that Non-Muscle β and γ Actin Are Not Equal in Relation to Human Melanoma Cells' Motility and Focal Adhesion Formation.	ACTB ACTG1	9.55e-06	2	108	2	32326615
Pubmed	Severe forms of Baraitser-Winter syndrome are caused by ACTB mutations rather than ACTG1 mutations.	ACTB ACTG1	9.55e-06	2	108	2	23756437
Pubmed	Cytochalasin D-induced actin gene expression in murine erythroleukemia cells.	ACTB ACTG1	9.55e-06	2	108	2	8482333
Pubmed	Isolation of cDNA clones for mouse cytoskeletal gamma-actin and differential expression of cytoskeletal actin mRNAs in mouse cells.	ACTB ACTG1	9.55e-06	2	108	2	3221869
Pubmed	Impaired muscle relaxation and mitochondrial fission associated with genetic ablation of cytoplasmic actin isoforms.	ACTB ACTG1	9.55e-06	2	108	2	29265728
Pubmed	Multi-isotope imaging mass spectrometry reveals slow protein turnover in hair-cell stereocilia.	ACTB ACTG1	9.55e-06	2	108	2	22246323
Pubmed	Structure, chromosome location, and expression of the human gamma-actin gene: differential evolution, location, and expression of the cytoskeletal beta- and gamma-actin genes.	ACTB ACTG1	9.55e-06	2	108	2	2837653
Pubmed	Human Argonaute2 and Argonaute3 are catalytically activated by different lengths of guide RNA.	AGO2 AGO3	9.55e-06	2	108	2	33122430
Pubmed	Prevalence of Cytoplasmic Actin Mutations in Diffuse Large B-Cell Lymphoma and Multiple Myeloma: A Functional Assessment Based on Actin Three-Dimensional Structures.	ACTB ACTG1	9.55e-06	2	108	2	32349449
Pubmed	Deficiency of the cytoskeletal protein SPECC1L leads to oblique facial clefting.	SPECC1L SPECC1	9.55e-06	2	108	2	21703590
Pubmed	Baraitser-Winter cerebrofrontofacial syndrome: Report of two adult siblings.	ACTB ACTG1	9.55e-06	2	108	2	32506774
Pubmed	Differential arginylation of actin isoforms is regulated by coding sequence-dependent degradation.	ACTB ACTG1	9.55e-06	2	108	2	20847274
Pubmed	Measurements of spatiotemporal changes in G-actin concentration reveal its effect on stimulus-induced actin assembly and lamellipodium extension.	ACTB ACTG1	9.55e-06	2	108	2	21502360
Pubmed	The evolution and complexity of the genes encoding the cytoskeletal proteins of human epidermal cells.	ACTB ACTG1	9.55e-06	2	108	2	6686106
Pubmed	Actin amino-acid sequences. Comparison of actins from calf thymus, bovine brain, and SV40-transformed mouse 3T3 cells with rabbit skeletal muscle actin.	ACTB ACTG1	9.55e-06	2	108	2	213279
Pubmed	The First Korean Case of Baraitser-Winter Cerebro-Fronto-Facial Syndrome with a Novel Mutation in ACTB Diagnosed Via Targeted Gene Panel Sequencing and Literature Review.	ACTB ACTG1	9.55e-06	2	108	2	33334799
Pubmed	β-Actin specifically controls cell growth, migration, and the G-actin pool.	ACTB ACTG1	9.55e-06	2	108	2	21900491
Pubmed	[The nucleotide sequence features of the mature microRNA seem to be responsible for the affinity to human Ago2 AND Ago3 proteins].	AGO2 AGO3	9.55e-06	2	108	2	21634124
Pubmed	Identification of a novel actin isoform in hepatocellular carcinoma.	ACTBL2 ACTB ACTG1	1.29e-05	15	108	3	16824795
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	PRPF31 ACTBL2 ACTB SPECC1L URB2 ARHGAP39 TRRAP SPECC1 NSD3 NSUN5 CNOT9 XRN1 RBM15B OTUD4 EIF3F EIF2A	1.55e-05	1497	108	16	31527615
Pubmed	Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs.	PRPF31 AGO2 ACTB AGO3 OTUD4	1.64e-05	101	108	5	19167051
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	PRPF31 ACTBL2 ACTG1 TRRAP TRAP1 PKD1	2.71e-05	187	108	6	26460568
Pubmed	OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.	OTUB2 OTUD4 TNFAIP3	2.72e-05	19	108	3	23827681
Pubmed	Cytoskeletal scaffolding proteins interact with Lynch-Syndrome associated mismatch repair protein MLH1.	ACTG1 NT5C3B ASS1 EIF2A	2.85e-05	56	108	4	20706999
Pubmed	Turning catalytically inactive human Argonaute proteins into active slicer enzymes.	AGO2 AGO3	2.86e-05	3	108	2	23665583
Pubmed	Molecular characterization of abLIM, a novel actin-binding and double zinc finger protein.	ACTB ACTG1	2.86e-05	3	108	2	9245787
Pubmed	Impact of altered actin gene expression on vinculin, talin, cell spreading, and motility.	ACTB ACTG1	2.86e-05	3	108	2	7646816
Pubmed	Adipose-derived stem cell exosome NFIC improves diabetic foot ulcers by regulating miR-204-3p/HIPK2.	HIPK2 NFIC	2.86e-05	3	108	2	37710299
Pubmed	Molecular basis for G-actin binding to RPEL motifs from the serum response factor coactivator MAL.	ACTB ACTG1	2.86e-05	3	108	2	19008859
Pubmed	Angiostatin and plasminogen share binding to endothelial cell surface actin.	ACTB ACTG1	2.86e-05	3	108	2	15746964
Pubmed	Interaction of Receptor-Binding Domain of the SARS-CoV-2 Omicron Variant with hACE2 and Actin.	ACTB ACTG1	2.86e-05	3	108	2	39195208
Pubmed	The roles of individual mammalian argonautes in RNA interference in vivo.	AGO2 AGO3	2.86e-05	3	108	2	24992693
Pubmed	Actin Is Crucial for All Kinetically Distinguishable Forms of Endocytosis at Synapses.	ACTB ACTG1	2.86e-05	3	108	2	27840001
Pubmed	Restricted morphological and behavioral abnormalities following ablation of β-actin in the brain.	ACTB ACTG1	2.86e-05	3	108	2	22403730
Pubmed	Functional molecular complexes of human N-formyl chemoattractant receptors and actin.	ACTB ACTG1	2.86e-05	3	108	2	8228254
Pubmed	CTGF/Hcs24 interacts with the cytoskeletal protein actin in chondrocytes.	ACTB ACTG1	2.86e-05	3	108	2	12470643
Pubmed	DPP9's Enzymatic Activity and Not Its Binding to CARD8 Inhibits Inflammasome Activation.	DPP8 CARD8	2.86e-05	3	108	2	31525884
Pubmed	Isolation and characterization of full-length cDNA clones for human alpha-, beta-, and gamma-actin mRNAs: skeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed.	ACTB ACTG1	2.86e-05	3	108	2	6865942
Pubmed	Update on the Regulation of HIPK1, HIPK2 and HIPK3 Protein Kinases by microRNAs.	HIPK1 HIPK2	2.86e-05	3	108	2	29793420
Pubmed	Mutation analysis of the short cytoplasmic domain of the cell-cell adhesion molecule CEACAM1 identifies residues that orchestrate actin binding and lumen formation.	ACTB ACTG1	2.86e-05	3	108	2	17192268
Pubmed	Argonaute2 is the catalytic engine of mammalian RNAi.	AGO2 AGO3	2.86e-05	3	108	2	15284456
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PDS5B HIPK1 URB2 FHIP2A EPG5 SETDB1 GSE1 OTUD4	4.17e-05	407	108	8	12693553
Pubmed	PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells.	ACTBL2 ACTB ACTG1 TRRAP	5.15e-05	65	108	4	22496869
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	CACHD1 CEMIP SETDB1 CNTNAP2 IFT80	5.53e-05	130	108	5	12421765
Pubmed	E2F transcriptional activation requires TRRAP and GCN5 cofactors.	E2F1 TRRAP	5.71e-05	4	108	2	11418595
Pubmed	L1 endocytosis is controlled by a phosphorylation-dephosphorylation cycle stimulated by outside-in signaling by L1.	ACTB ACTG1	5.71e-05	4	108	2	12082080
Pubmed	β-actin and γ-actin are each dispensable for auditory hair cell development but required for Stereocilia maintenance.	ACTB ACTG1	5.71e-05	4	108	2	20976199
Pubmed	Molecular dissection of human Argonaute proteins by DNA shuffling.	AGO2 AGO3	5.71e-05	4	108	2	23748378
Pubmed	Multiple molecular interactions determine the clustering of Caspr2 and Kv1 channels in myelinated axons.	CNTNAP2 DLG2	5.71e-05	4	108	2	19109503
Pubmed	Functional analyses of placental protein 13/galectin-13.	ACTB ACTG1	5.71e-05	4	108	2	15009185
Pubmed	The formin-homology-domain-containing protein FHOD1 enhances cell migration.	ACTB ACTG1	5.71e-05	4	108	2	12665555
Pubmed	Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs.	AGO2 AGO3	5.71e-05	4	108	2	15260970
Pubmed	Molecular cloning and functional characterization of mouse coactosin-like protein.	ACTB ACTG1	5.71e-05	4	108	2	11785969
Pubmed	IQGAP1 regulates reactive oxygen species-dependent endothelial cell migration through interacting with Nox2.	ACTB ACTG1	5.71e-05	4	108	2	16179592
Pubmed	The deubiquitinating enzyme, ubiquitin-specific peptidase 50, regulates inflammasome activation by targeting the ASC adaptor protein.	USP50 TNFAIP3	5.71e-05	4	108	2	28094437
Pubmed	miR-29 acts as a decoy in sarcomas to protect the tumor suppressor A20 mRNA from degradation by HuR.	AGO2 TNFAIP3	5.71e-05	4	108	2	23901138
Pubmed	Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes.	ACTB ACTG1	5.71e-05	4	108	2	6893015
Pubmed	Functional role of a long non-coding RNA LIFR-AS1/miR-29a/TNFAIP3 axis in colorectal cancer resistance to pohotodynamic therapy.	AGO2 TNFAIP3	5.71e-05	4	108	2	29807108
Pubmed	Rare structural variants found in attention-deficit hyperactivity disorder are preferentially associated with neurodevelopmental genes.	RBFOX1 CNTNAP2	5.71e-05	4	108	2	19546859
Pubmed	The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins.	E2F1 TRRAP	5.71e-05	4	108	2	9708738
Pubmed	Argonaute proteins: potential biomarkers for human colon cancer.	AGO2 AGO3	5.71e-05	4	108	2	20146808
Pubmed	Slicing-independent RISC activation requires the argonaute PAZ domain.	AGO2 AGO3	5.71e-05	4	108	2	22795694
Pubmed	Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation.	HIPK1 HIPK2	5.71e-05	4	108	2	34785661
Pubmed	The proline-rich domain of tau plays a role in interactions with actin.	ACTB ACTG1	5.71e-05	4	108	2	19895707
Pubmed	Stabilization of HIPK2 by escape from proteasomal degradation mediated by the E3 ubiquitin ligase Siah1.	HIPK1 HIPK2	5.71e-05	4	108	2	19250734
Pubmed	Effect of tyrosine autophosphorylation on catalytic activity and subcellular localisation of homeodomain-interacting protein kinases (HIPK).	HIPK1 HIPK2	5.71e-05	4	108	2	25630557
Pubmed	ATP-dependent human RISC assembly pathways.	AGO2 AGO3	5.71e-05	4	108	2	19966796
Pubmed	Importance of translation and nonnucleolytic ago proteins for on-target RNA interference.	AGO2 AGO3	5.71e-05	4	108	2	18771919
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	PDS5B PRPF31 AGO2 ACTB URB2 COLGALT1 TRRAP NSUN5 ASNS ASS1 XRN1 EIF3F EIF2A CPSF3	7.83e-05	1353	108	14	29467282
Pubmed	Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN.	RADX ACTBL2 ACTB PSMB7 ACTG1 SPECC1L EIF3F	8.61e-05	334	108	7	30425250
Pubmed	E-cadherin expression on multiple myeloma cells activates tumor-promoting properties in plasmacytoid DCs.	ACTG1 XRN1 TNFAIP3	9.02e-05	28	108	3	30277474
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	PRPF31 MCM8 ATG2A FHIP2A NUFIP1 SETDB1 NEK1 AGO3 CNOT9 XRN1 OTUD4 AJUBA	9.43e-05	1038	108	12	26673895
Pubmed	Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors.	AGO2 AGO3	9.50e-05	5	108	2	12526743
Pubmed	Differential expression of Dicer and Argonaute genes during the differentiation of human neuroblastoma cells.	AGO2 AGO3	9.50e-05	5	108	2	19393748
Pubmed	HIV-1 Gag-RNA interaction occurs at a perinuclear/centrosomal site; analysis by confocal microscopy and FRET.	ACTB ACTG1	9.50e-05	5	108	2	16101678
Pubmed	ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons.	CNTNAP2 DLG2	9.50e-05	5	108	2	20089912
Pubmed	Microtubule associated protein MAP1A is an actin-binding and crosslinking protein.	ACTB ACTG1	9.50e-05	5	108	2	7820861
Pubmed	Monitoring of S protein maturation in the endoplasmic reticulum by calnexin is important for the infectivity of severe acute respiratory syndrome coronavirus.	ACTB ACTG1	9.50e-05	5	108	2	22915798
Pubmed	Nonredundant roles of cytoplasmic β- and γ-actin isoforms in regulation of epithelial apical junctions.	ACTB ACTG1	9.50e-05	5	108	2	22855531
Pubmed	Differential expression of components of the microRNA machinery during mouse organogenesis.	AGO2 AGO3	9.50e-05	5	108	2	16036130
Pubmed	Quantitative functions of Argonaute proteins in mammalian development.	AGO2 AGO3	9.50e-05	5	108	2	22474261
Pubmed	The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis.	AGO2 AGO3	9.50e-05	5	108	2	12414724
Pubmed	IKK/NF-kappaB signaling pathway inhibits cell-cycle progression by a novel Rb-independent suppression system for E2F transcription factors.	E2F1 TRRAP	9.50e-05	5	108	2	18542057
Pubmed	The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing.	AGO2 AGO3	9.50e-05	5	108	2	19324964
Pubmed	Epigenetic involvement of Alien/ESET complex in thyroid hormone-mediated repression of E2F1 gene expression and cell proliferation.	E2F1 SETDB1	9.50e-05	5	108	2	22079090
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	AGO2 HMX3 AGO3 NFIC RBFOX1 XRN1 OTUD4 DLG2	1.01e-04	462	108	8	31138677
GeneFamily	OTU domain containing	OTUB2 OTUD4 TNFAIP3	2.78e-05	17	64	3	669
GeneFamily	Actins	ACTB ACTG1	1.83e-04	6	64	2	929
GeneFamily	Argonaute/PIWI family	AGO2 AGO3	3.41e-04	8	64	2	408
ToppCell	Control-Endothelial-VE_Venous\|Endothelial / Disease state, Lineage and Cell class	CACHD1 OMD PTPRB GSE1 ST8SIA6 SLCO2A1 ASS1 TNFAIP3 PDZRN4	9.64e-10	190	108	9	4e30155203b4a8c5e496fcbe9348b67b98ebc625
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal-Neuron\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	ACTB ACTG1 MFAP2 ASS1 CNTNAP2 EXOC3L1	7.44e-07	129	108	6	64768adf23123b92280fb30eb85147cbee084ae0
ToppCell	facs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l34\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1E MGAT4A ITGA10 OMD CEMIP PDZRN4	4.52e-06	176	108	6	77c3da2eaa072a6baefb5087fd07ec18c5e271cd
ToppCell	Healthy_Control-Lymphoid-T-Treg\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	CACHD1 SH2D2A F5 CHRM5 ASNS AJUBA	4.52e-06	176	108	6	7765a5b04ac117d525201f8eb08e1754e55942ff
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-ventral_progenitors_and_neurons_2\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	RNASEH2B ACTB ACTG1 E2F1 GSE1 ASS1	4.99e-06	179	108	6	d95367d689732ab2653e8d70d8d8e5eb15ae6eef
ToppCell	COVID-19-Heart-EC_3\|Heart / Disease (COVID-19 only), tissue and cell type	MGAT4A CACHD1 PTPRB GSE1 ST8SIA6 SLCO2A1	7.01e-06	190	108	6	78e7c502b0450c0b37652b1896a2a752fd8a2111
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-stromal_related\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MGAT4A ACTB ITGA10 MFAP2 SLCO2A1 CNTNAP2	7.45e-06	192	108	6	8ad6678df89175c5a4a835c8566f1552df3c996e
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-stromal_related-ICC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MGAT4A ACTB ITGA10 MFAP2 SLCO2A1 CNTNAP2	7.45e-06	192	108	6	2f5378ea0b2fb2f672a36585d375f675983363a1
ToppCell	IPF-Endothelial-VE_Venous\|Endothelial / Disease state, Lineage and Cell class	ITGA10 PTPRB ST8SIA6 SLCO2A1 TNFAIP3 PDZRN4	7.90e-06	194	108	6	e8a9005963704286bcc50785bda8d7d63ec001b1
ToppCell	distal-Endothelial-Vein-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CACHD1 OMD PTPRB SLCO2A1 ASS1 PDZRN4	8.62e-06	197	108	6	3d71c93da4b88ebbd58e68ed3dbf610d4bcfc4f5
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-double_negative_T_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPHS1 ARHGAP39 RBM15B CPSF3 PADI3	5.59e-05	168	108	5	de1042267407719f19eb3f580a5df0c9cd0e8273
ToppCell	PND10-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MGAT4A HIPK2 E2F1 DPP8 CNOT9	5.75e-05	169	108	5	3e40ae0b23a962e0f15908872dec63f51c5b8b83
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA10 SH2D2A NEB TNFAIP3 IFT80	6.08e-05	171	108	5	8719a18c9e6b6f5d8ec4e937c2bda1e36441c9ec
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-BM_CD4_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA10 SH2D2A NEB TNFAIP3 IFT80	6.08e-05	171	108	5	f4cdd7862c8fe99ee765a2f3ed375b584f4976c5
ToppCell	droplet-Kidney-nan-3m-Epithelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPHS1 KLHL40 R3HDML SLCO2A1 RHBDL3	6.25e-05	172	108	5	073a503dc922e3e3ac3528e249b0f8b74402110b
ToppCell	tumor_Lymph_Node_/_Brain-T/NK_cells-CD8+/CD4+_Mixed_Th\|T/NK_cells / Location, Cell class and cell subclass	PTPN21 NEB CCNB3 TNFAIP3 LILRB4	6.42e-05	173	108	5	42c911ed16fabdabef063830e8407192d8bde950
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	TNRC18 GSE1 RBFOX1 CNTNAP2 DLG2	7.95e-05	181	108	5	c80ffa2ded5975a88e9a1a7d333196f95237bf0a
ToppCell	3'-Pediatric_IBD-SmallIntestine-Hematopoietic-T_cells-Th1\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MGAT4A ACTB ACTG1 SH2D2A TNFAIP3	8.81e-05	185	108	5	326c8b6ea0e9140616d7b867db1385b980dc3678
ToppCell	LV-10._Endothelium_II\|World / Chamber and Cluster_Paper	ITGA10 PTPRB ST8SIA6 SLCO2A1 DNAJC5G	9.27e-05	187	108	5	7876dcb4800c2e54874df3d933efb79307a64a97
ToppCell	COVID-19-Endothelial_cells-Pulmonary_venous_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	ITGA10 PTPRB ST8SIA6 SLCO2A1 PDZRN4	9.27e-05	187	108	5	2d20193a6cacdfa4877457c97b0077408942186c
ToppCell	Control-Endothelial-VE_Venous\|World / Disease state, Lineage and Cell class	ITGA10 PTPRB ST8SIA6 SLCO2A1 PDZRN4	9.74e-05	189	108	5	f83f7521e377ded1522639e9a35c98b3e2725bac
ToppCell	COVID-19-Heart-EC_(POSTN)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ITGA10 F5 PTPRB ST8SIA6 SLCO2A1	9.74e-05	189	108	5	7346c1112e2e155dbd71b6dbc80e680fd262a691
ToppCell	RA-10._Endothelium_II\|World / Chamber and Cluster_Paper	ITGA10 HIPK2 PTPRB ST8SIA6 SLCO2A1	9.74e-05	189	108	5	75c248b9de5e2fb7a0baa8cdbab516e575cc4394
ToppCell	RA-10._Endothelium_II\|RA / Chamber and Cluster_Paper	ITGA10 HIPK2 PTPRB ST8SIA6 SLCO2A1	9.74e-05	189	108	5	c81787a8c662db5d7814c583dd64562857629e81
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-lymphocytic-T_lymphocytic-regulatory_T_cell\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ACTB ACTG1 SH2D2A F5 TNFAIP3	9.99e-05	190	108	5	b69709323a9f1b368b5a4f87295b9f7fd9c9be8e
ToppCell	Control-Endothelial-VE_Venous\|Control / Disease state, Lineage and Cell class	ITGA10 PTPRB ST8SIA6 SLCO2A1 PDZRN4	1.02e-04	191	108	5	617546cf4883dedf3323e03a53ba5adec334cf8e
ToppCell	PCW_07-8.5-Endothelial-Endothelial_mature-endo_venous_(13)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	MGAT4A PTPRB ST8SIA6 SLCO2A1 EXOC3L1	1.02e-04	191	108	5	54029b68fb78163c969890886ab0f8fb0dcf3c20
ToppCell	10x5'v1-week_14-16-Mesenchymal_fibro-stroma-endosteal_fibroblast\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	ITGA10 PTPN21 MFAP2 DLG2 PDZRN4	1.02e-04	191	108	5	44b1f62fdee03b157fe545f2ae6ff84f8929a8ac
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Artery\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SPECC1 F5 PTPRB ST8SIA6 ASNS	1.02e-04	191	108	5	4b3d5157344dbfbf4fab518611cd9fa37fac7bd9
ToppCell	Brain_organoid-organoid_Velasco_nature-6_mon-IPC_like-IPCs\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	ACTB ACTG1 ITPRID1 MFAP2 CNTNAP2	1.05e-04	192	108	5	bd91bf0ceeac49dc5a18aa2e401244db0ca596ae
ToppCell	ILEUM-non-inflamed-(1)_Th17_Trm\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	MGAT4A ACTB ACTG1 SH2D2A TNFAIP3	1.05e-04	192	108	5	7347ff4dedd1aaa489c4f15e5ae647a4ce39ac72
ToppCell	Brain_organoid-organoid_Velasco_nature-6_mon-IPC_like\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	ACTB ACTG1 ITPRID1 MFAP2 CNTNAP2	1.05e-04	192	108	5	18fbf485ad762ba7a9ac3e19bad136b0cf3af3c5
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SPECC1 MFAP2 MOXD1 PTPRB ASS1	1.05e-04	192	108	5	cd4c9b9ab17a779c154264f7459020f51e528ba5
ToppCell	ILEUM-inflamed-(1)_Th17_Trm\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	MGAT4A ACTB ACTG1 SH2D2A TNFAIP3	1.07e-04	193	108	5	0663c57e1b8b8dd70d617d029fc7bdbbda8c1208
ToppCell	RV-10._Endothelium_II\|RV / Chamber and Cluster_Paper	ITGA10 HIPK2 PTPRB ST8SIA6 SLCO2A1	1.07e-04	193	108	5	01c2df9206f1527c578e808978e58196c35e72f5
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-T_lymphocytic-naive_regulatory_T_cell\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ACTB ACTG1 SH2D2A F5 TNFAIP3	1.07e-04	193	108	5	28138c35ea82c6b2163f0cae045ca55859347c73
ToppCell	RV-10._Endothelium_II\|World / Chamber and Cluster_Paper	ITGA10 HIPK2 PTPRB ST8SIA6 SLCO2A1	1.07e-04	193	108	5	2531266bc57339d4e2b22a88817008e32b8c1598
ToppCell	LV-10._Endothelium_II\|LV / Chamber and Cluster_Paper	ITGA10 HIPK2 PTPRB ST8SIA6 SLCO2A1	1.10e-04	194	108	5	b6cc849fa08599bff9839ef382d190cc964e273e
ToppCell	IPF-Endothelial-VE_Capillary_B\|IPF / Disease state, Lineage and Cell class	ITGA10 PTPRB ST8SIA6 SLCO2A1 EXOC3L1	1.10e-04	194	108	5	169a304d5c13f08c39fad4116f093bc4a0765e9d
ToppCell	PCW_10-12-Endothelial-Endothelial_immature-endo_immature4_(5)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	MGAT4A PTPRB ST8SIA6 PIP5K1B EXOC3L1	1.10e-04	194	108	5	53a5e8863d79a052dff0758f389be5ac3883c721
ToppCell	Mesenchymal_cells-Fibro/Chondro_p.\|Mesenchymal_cells / Lineage and Cell class	ITGA10 OMD R3HDML F5 CEMIP	1.13e-04	195	108	5	b95a631d54c6cf85e48e1e638703206aaaebc073
ToppCell	Tracheal-10x3prime_v2-Epithelial-Epi_submucosal-gland-SMG_Duct\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ACTBL2 E2F1 URB2 ITPRID1 RBFOX1	1.13e-04	195	108	5	fdbb4abc0c79a6aeace71bfa5a5c5576ca39d758
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MGAT4A ACTG1 SH2D2A ATG2A TNFAIP3	1.16e-04	196	108	5	c100967851f037b3522130a9e2a4175ad593ecbc
ToppCell	PCW_10-12-Endothelial-Endothelial_immature-endo_immature_venous_(4)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	MGAT4A PTPRB ST8SIA6 SLCO2A1 EXOC3L1	1.16e-04	196	108	5	81278e696d823744267d6315c4d42799c4ea0b2c
ToppCell	COPD-Endothelial-VE_Capillary_B\|Endothelial / Disease state, Lineage and Cell class	MGAT4A HIPK2 PTPRB SLCO2A1 PIP5K1B	1.18e-04	197	108	5	30dbc05ea66892d2e18ff375ffa86d1db7bc4083
ToppCell	facs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l34\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MGAT4A ITGA10 OMD CEMIP PDZRN4	1.18e-04	197	108	5	6e111ba16fc8adde782b3f7da250248cddf11228
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-T_lymphocytic\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MGAT4A ACTB ACTG1 SH2D2A TNFAIP3	1.21e-04	198	108	5	db107a5511571384f26e26c6301aef9a9f2423c4
ToppCell	TCGA-Colorectal-Primary_Tumor\|TCGA-Colorectal / Sample_Type by Project: Shred V9	E2F1 URB2 CEMIP CNOT9 AJUBA	1.24e-04	199	108	5	c7d6a8398f2419b726a0461585d1ee0561654e3b
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Perivascular_fibroblast\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ITGA10 OMD CEMIP NEK1 ASS1	1.24e-04	199	108	5	dfc5c7a4a093baa7158dd8d4d29a870d9c469a3f
ToppCell	Transverse-T_cell-Th17\|Transverse / Region, Cell class and subclass	MGAT4A ACTB ACTG1 SH2D2A TNFAIP3	1.24e-04	199	108	5	640989e048b08d66c5020e032a61ef05f3831034
ToppCell	Caecum-T_cell\|Caecum / Region, Cell class and subclass	MGAT4A ACTB ACTG1 SH2D2A TNFAIP3	1.24e-04	199	108	5	4971ba943256f6390dffabf43e45d4e86ce94b46
ToppCell	Transverse-(1)_T_cell-(13)_Th17\|Transverse / shred on region, Cell_type, and subtype	MGAT4A ACTB ACTG1 SH2D2A TNFAIP3	1.24e-04	199	108	5	3b17c2704317cac0d641e673563098fd8ca19bd8
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ITGA10 OMD PTPRB ST8SIA6 SLCO2A1	1.24e-04	199	108	5	236b1417ed0875e98c6ec1ec714003bfce438d65
ToppCell	Transverse-T_cell\|Transverse / Region, Cell class and subclass	MGAT4A ACTB ACTG1 SH2D2A TNFAIP3	1.24e-04	199	108	5	d33dae977d168d07c004ccfa9da4f6e5c670734a
ToppCell	Caecum-(1)_T_cell\|Caecum / shred on region, Cell_type, and subtype	MGAT4A ACTB ACTG1 SH2D2A TNFAIP3	1.24e-04	199	108	5	9e8d121550d60091d82f236d7c67361291aaf0e0
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma\|TCGA-Colorectal / Sample_Type by Project: Shred V9	E2F1 URB2 CEMIP CNOT9 AJUBA	1.24e-04	199	108	5	85b3b1ad01368dae4adbc9da7efc148e49992f69
ToppCell	Transverse-(1)_T_cell\|Transverse / shred on region, Cell_type, and subtype	MGAT4A ACTB ACTG1 SH2D2A TNFAIP3	1.24e-04	199	108	5	3c0bd5e11bc99f1b57034f81a923832207060fb0
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Perivascular_fibroblast-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ITGA10 OMD CEMIP NEK1 ASS1	1.24e-04	199	108	5	c1760581c34b81d1d92c67500a1c8944e9cc6dad
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW09-Neuronal\|GW09 / Sample Type, Dataset, Time_group, and Cell type.	CACNA1E ACTB ACTG1 ASNS CNTNAP2	1.27e-04	200	108	5	e9eb348a66011d8aace4331f84690ae27cb0d061
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW26-Neuronal-GABAergic_neurons\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	DOCK3 CACNA1E TMEM212 CNTNAP2 PDZRN4	1.27e-04	200	108	5	bad32a95b759fad509401b07bc96a56687c2a592
ToppCell	(1)_T_cell\|World / shred on Cell_type and subtype	MGAT4A ACTB ACTG1 SH2D2A TNFAIP3	1.27e-04	200	108	5	39c6fcefba9047a375e78d8f88af4c45da8ebde8
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal\|GW09 / Sample Type, Dataset, Time_group, and Cell type.	CACNA1E ACTB ACTG1 ASNS CNTNAP2	1.27e-04	200	108	5	09fd3cb31bcc02444f1045f01fe39bce09359d35
ToppCell	(13)_Th17\|World / shred on Cell_type and subtype	HIPK1 MGAT4A ACTB SH2D2A TNFAIP3	1.36e-04	203	108	5	e8d5db46093160d403ecd51142c3939d522bca8b
Disease	autosomal dominant nonsyndromic deafness 20 (implicated_via_orthology)	ACTBL2 ACTB ACTG1	2.28e-06	8	103	3	DOID:0110550 (implicated_via_orthology)
Disease	Baraitser-Winter syndrome 1 (implicated_via_orthology)	ACTBL2 ACTB ACTG1	2.28e-06	8	103	3	DOID:0081112 (implicated_via_orthology)
Disease	Moyamoya disease (implicated_via_orthology)	ACTBL2 ACTB ACTG1	2.28e-06	8	103	3	DOID:13099 (implicated_via_orthology)
Disease	thoracic aortic aneurysm (implicated_via_orthology)	ACTBL2 ACTB ACTG1	2.28e-06	8	103	3	DOID:14004 (implicated_via_orthology)
Disease	intestinal atresia (implicated_via_orthology)	ACTBL2 ACTB ACTG1	4.87e-06	10	103	3	DOID:10486 (implicated_via_orthology)
Disease	patent ductus arteriosus (implicated_via_orthology)	ACTBL2 ACTB ACTG1	4.87e-06	10	103	3	DOID:13832 (implicated_via_orthology)
Disease	Iris Coloboma with Ptosis, Hypertelorism, and Mental Retardation	ACTB ACTG1	1.21e-05	2	103	2	C1855722
Disease	Baraitser-Winter syndrome	ACTB ACTG1	1.21e-05	2	103	2	cv:C1853623
Disease	Fryns-Aftimos Syndrome	ACTB ACTG1	1.21e-05	2	103	2	C1853623
Disease	Macrostomia	ACTG1 SPECC1L	7.21e-05	4	103	2	C0024433
Disease	Intellectual Disability	RNASEH2B CACNA1E SPECC1L FHIP2A TRRAP ASS1 EIF3F EIF2A	1.76e-04	447	103	8	C3714756
Disease	longitudinal BMI measurement	CACNA1E NUFIP1 CNTNAP2 DLG2	1.99e-04	82	103	4	EFO_0005937
Disease	Uveoretinal Coloboma	ACTB ACTG1	2.51e-04	7	103	2	C4554007
Disease	nemaline myopathy (implicated_via_orthology)	ACTB NEB	3.33e-04	8	103	2	DOID:3191 (implicated_via_orthology)
Disease	Nemaline myopathy	KLHL40 NEB	3.33e-04	8	103	2	cv:C0206157
Disease	Congenital ocular coloboma (disorder)	ACTB ACTG1	4.28e-04	9	103	2	C0009363
Disease	Tendinopathy	CACNA1E CNTNAP2	4.28e-04	9	103	2	EFO_1001434
Disease	mean reticulocyte volume	PDS5B AGO2 SPECC1L URB2 DPP8 NEB TRRAP SPECC1 OTUD4 EIF3F	4.90e-04	799	103	10	EFO_0010701
Disease	Congenital neurologic anomalies	ACTB ACTG1	5.33e-04	10	103	2	C0497552
Disease	Cranioschisis	ACTB ACTG1	5.33e-04	10	103	2	C0265541
Disease	osteosarcoma (is_marker_for)	E2F1 PTPRB	6.50e-04	11	103	2	DOID:3347 (is_marker_for)
Disease	lower body strength measurement	HMX3 RBFOX1	1.40e-03	16	103	2	EFO_0007999
Disease	autosomal recessive polycystic kidney disease (implicated_via_orthology)	NEK1 PKD1	1.40e-03	16	103	2	DOID:0110861 (implicated_via_orthology)
Disease	mean corpuscular hemoglobin concentration	RNASEH2B PDS5B AGO2 ACTB URB2 DPP8 NEB SPECC1 RBFOX1 OTUD4 EIF3F	1.66e-03	1105	103	11	EFO_0004528
Disease	melanoma	E2F1 FHIP2A TRRAP SETDB1 DLG2	1.81e-03	248	103	5	C0025202
Disease	response to angiotensin-converting enzyme inhibitor	CNTNAP2 OTUD4 PIP5K1B	2.60e-03	78	103	3	EFO_0005325
Disease	Sensorineural Hearing Loss (disorder)	ACTB EIF3F	2.91e-03	23	103	2	C0018784
Disease	Dystonia	RNASEH2B CACNA1E ACTB	3.43e-03	86	103	3	C0013421

Protein segments in the cluster

Peptide	Gene	Start	Entry
LDSLLPPYHVHYFLV	URB2	906	Q14146
LDHRFSSYYLSLPPE	ASNS	421	P08243
APHYVPYLLAALNHK	EXOC3L1	481	Q86VI1
TYIPSLPKHYDIHRL	EPG5	1421	Q9HCE0
LHHYYPIEIDPHRTV	NT5C3B	81	Q969T7
FLYHPLPLPSYLHHT	nan	31	Q9N2J8
HASPQRYISEPYLAL	CACNA1E	2221	Q15878
PELHDIPIYYASSLA	CPSF3	261	Q9UKF6
THIVPIYEGYALPHA	ACTBL2	161	Q562R1
PSAYPELHAALDRLY	AJUBA	201	Q96IF1
HTVPIYEGYALPHAI	ACTB	161	P60709
HTVPIYEGYALPHAI	ACTG1	161	P63261
YPPELSHSSLAALHS	GSE1	306	Q14687
YLLSEPPLHTDIIHY	CACHD1	526	Q5VU97
LAAHIPLFLYPFLHT	CNOT9	111	Q92600
AFCALLHTYLPAHIP	SPECC1	996	Q5M775
FCALLHTYLPAHIPY	SPECC1L	1046	Q69YQ0
HTYLPAHIPYQELNS	SPECC1L	1051	Q69YQ0
VIHHVHSLYPSAPFL	ABHD3	201	Q8WU67
RSVSIPAPAYYAHLV	AGO3	796	Q9H9G7
YDPPTYIRDLSIHHT	CEMIP	571	Q8WUJ3
HPLYLEGALTRSTHY	CEMIP	1026	Q8WUJ3
LYHRAAVDDYPLPSH	ATG2A	991	Q2TAZ0
IYETPAGTILYHAHL	ASS1	281	P00966
SVSIPAPAYYAHLVA	AGO2	796	Q9UKV8
HYSGYSISELHPLVR	CCNB3	1326	Q8WWL7
LPVHYELLTDGYTRH	RBM15B	506	Q8NDT2
KAVSEHIPYLSPYHS	PDZRN4	821	Q6ZMN7
VVPYTIHLLAHDPDY	PDS5B	991	Q9NTI5
APHSYLYPLHQAYLA	OTUD4	716	Q01804
PLIPHEFYEQCIAHY	ARHGAP39	976	Q9C0H5
PHLYSIYPHGSTDKL	PSMB7	151	Q99436
PSDPRYHEVHYILLD	NSUN5	291	Q96P11
GLIDHLHYSRVYPES	RADX	691	Q6NSI4
HVFPEAATPSVYLLY	OTUB2	206	Q96DC9
KSLQVPSIYYHLPHL	MGAT4A	101	Q9UM21
PSIYYHLPHLLKNEG	MGAT4A	106	Q9UM21
PLDLQDPRYTEHTYH	NPHS1	881	O60500
QHPLPSYLEYRHNAS	PTPRB	1506	P23467
AFYTNVLPHSYHTPE	OR2T2	256	Q6IF00
AAAAHLPTQPHLYTY	HIPK2	1091	Q9H2X6
EPTYNPLHVQSHLYS	M1AP	436	Q8TC57
PPVSLHYSYDLRSLV	NEK1	221	Q96PY6
VPHIHARVYNYEPLT	MCM8	191	Q9UJA3
LTAEPPEHYSNLHQY	ITPRID1	946	Q6ZRS4
FSHYLLSHPSDPLEL	LILRB4	201	Q8NHJ6
APAHLPSQAHLYTYA	HIPK1	1101	Q86Z02
SQPLLTFPHPVYYSH	HMX3	331	A6NHT5
LATSHLPHFVPYASL	ATXN1L	166	P0C7T5
AHYDVLLSYPNKTHP	FOLH1	111	Q04609
TEYSYPPSKVHLIGH	PNLIPRP1	156	P54315
LYSHLQPTELHSYPD	OR51J1	126	Q9H342
SSSLYVNEHYPHDRP	PIP5K1B	481	O14986
DPLPYVVYGHTVLSH	KLHL40	446	Q2TBA0
HARLYYILLAHLAAP	AP5B1	611	Q2VPB7
YAPVLFTYIHPALES	OR12D2	251	P58182
ALVHCFSTHPYLSYP	OR13H1	81	Q8NG92
YHSSHEPLPLAYAVL	PADI3	96	Q9ULW8
YLPSHRHSAVIPPSY	PTPN21	431	Q16825
SYSHSALLPHPPFEY	DNAJC5G	36	Q8N7S2
VHISITPYPAILHEY	IFT80	581	Q9P2H3
SLSPPHEALDYHFGL	E2F1	401	Q01094
PYLPVHYSLSESAVL	DOCK3	1931	Q8IZD9
PYLPLHLHPDHYSRT	SDR42E1	141	Q8WUS8
IHEYYSREAPNPIHL	EIF3F	186	O00303
SPLEHHLYVVSYVNP	DPP8	546	Q6V1X1
TSNTLIYYHPHPEDI	CARD8	316	Q9Y2G2
DIPTRLLLSYDYHSP	MS4A6E	91	Q96DS6
ESTLHRYEVHPYGTL	ITGA10	946	O75578
LKLDHYPSVSYHLPS	CNTNAP2	1126	Q9UHC6
SAPYSHYHLGLLPDS	DLG2	376	Q15700
PRNAAYYSPHGHILV	EIF2A	316	Q9BY44
HIHEYLLDPYVNLAP	FHIP2A	671	Q5W0V3
LHAFSVEPLLIYPTH	COLGALT1	546	Q8NBJ5
YRPVSVAVIHHPLYH	PROCA1	151	Q8NCQ7
LLDYHNHIRASVYPP	R3HDML	66	Q9H3Y0
LPPFPDHVQYTHYSD	MFAP2	26	P55001
YLAVYLHSEPRPNEH	PKD1	2941	P98161
DRYLAICHPLHYPSI	OR11H7	121	Q8NGC8
CPSIDPLHYHHLTYI	OMD	321	Q99983
DRYAAICHPLHYPTL	OR10R2	141	Q8NGX6
VYAADPYHHALAPAP	RBFOX1	336	Q9NWB1
LLLHYTAHPLSPYGE	SH2D2A	166	Q9NP31
THDDPPCLTHIYYSH	F5	161	P12259
VTHPRYLKNSLVYHP	RHBDL3	191	P58872
EDIPVSHHYYDNKLP	ST8SIA6	351	P61647
KPPIYHFYSHIVSND	TECTB	91	Q96PL2
STYFPHTAIRYPPHL	NFIC	386	P08651
LLSGNHIAYDYHPPA	SETDB1	241	Q15047
YDTPNYLLSPAAAHR	CHRM5	356	P08912
ATIHYPALDGHLSRY	YKT6	116	O15498
TLPHFLSEPYQYTLA	SLCO2A1	116	Q92959
FSHLPSGLYPSYLHL	TNRC18	116	O15417
SGLYPSYLHLNHLEP	TNRC18	121	O15417
HFSLFSTSPLLPHYI	TRIM77	386	I1YAP6
VDPPHYEEYHLTLQA	TMEM212	136	A6NML5
INTGYFIPYLHLVAH	SLC16A13	226	Q7RTY0
PLDPHYVLLEVHYDN	MOXD1	296	Q6UVY6
YQTLFEPRTHHPYLL	NUFIP1	441	Q9UHK0
YPIVLGYDSHHFVPL	TNFAIP3	246	P21580
HFATPVDPLFLLLHY	RNASEH2B	86	Q5TBB1
IHEKSPYLLQHAYNP	SPATA20	66	Q8TB22
PVPYQAYPHLISSDH	RNF44	166	Q7L0R7
AYPHLISSDHYILHP	RNF44	171	Q7L0R7
SVLPHTGYIYHSDIV	PRPF31	266	Q8WWY3
HINHDALPLLYGTYV	XRN1	301	Q8IZH2
TDIHYPLTNLDLTPY	USP50	286	Q70EL3
YYHSEIPNTRPHEIL	NSD3	111	Q9BZ95
CAPNRHLAEHSPYYE	TRAP1	501	Q12931
SHPILYFTNGHLYPT	VSIG2	71	Q96IQ7
YLLQYATLLVEHAPH	TRRAP	1831	Q9Y4A5
LPYVHLPISSYLNHA	TMEM260	231	Q9NX78
LVPYTSEHVPSRYHE	NAT9	16	Q9BTE0
DYKHILHSYSYPPDS	NEB	916	P20929