Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNAH7 DYNC1H1	5.02e-04	18	37	2	GO:0008569
GeneOntologyMolecularFunction	dynein light intermediate chain binding	DNAH7 DYNC1H1	1.23e-03	28	37	2	GO:0051959
GeneOntologyMolecularFunction	cytoskeletal motor activity	DNAH7 DYNC1H1 MYO3B	1.35e-03	118	37	3	GO:0003774
GeneOntologyMolecularFunction	phosphatase binding	DZIP3 SMG5 KAT2A SBF2	1.40e-03	264	37	4	GO:0019902
GeneOntologyMolecularFunction	dynein intermediate chain binding	DNAH7 DYNC1H1	2.14e-03	37	37	2	GO:0045505
GeneOntologyMolecularFunction	translation initiation factor binding	EIF3C EIF3CL	2.37e-03	39	37	2	GO:0031369
GeneOntologyCellularComponent	eukaryotic translation initiation factor 3 complex, eIF3m	EIF3C EIF3CL	1.09e-04	9	37	2	GO:0071541
GeneOntologyCellularComponent	cilium	ADCY10 RSPH10B2 ARMC9 IFT122 PDE6B DNAH7 RSPH10B MYO3B	1.43e-04	898	37	8	GO:0005929
GeneOntologyCellularComponent	eukaryotic translation initiation factor 3 complex	EIF3C EIF3CL	3.60e-04	16	37	2	GO:0005852
GeneOntologyCellularComponent	eukaryotic 48S preinitiation complex	EIF3C EIF3CL	4.58e-04	18	37	2	GO:0033290
GeneOntologyCellularComponent	eukaryotic 43S preinitiation complex	EIF3C EIF3CL	5.11e-04	19	37	2	GO:0016282
GeneOntologyCellularComponent	translation preinitiation complex	EIF3C EIF3CL	5.68e-04	20	37	2	GO:0070993
GeneOntologyCellularComponent	microtubule organizing center	GPSM2 ARMC9 IFT122 KAT2A TM9SF2 VPS4A DYNC1H1	1.01e-03	919	37	7	GO:0005815
GeneOntologyCellularComponent	photoreceptor cell cilium	IFT122 PDE6B MYO3B	1.89e-03	139	37	3	GO:0097733
GeneOntologyCellularComponent	9+0 non-motile cilium	IFT122 PDE6B MYO3B	2.49e-03	153	37	3	GO:0097731
GeneOntologyCellularComponent	ciliary tip	ARMC9 IFT122	3.27e-03	48	37	2	GO:0097542
GeneOntologyCellularComponent	motile cilium	ADCY10 RSPH10B2 DNAH7 RSPH10B	3.47e-03	355	37	4	GO:0031514
GeneOntologyCellularComponent	cytoplasmic region	GPSM2 DNAH7 DYNC1H1 RSPH10B	3.65e-03	360	37	4	GO:0099568
GeneOntologyCellularComponent	dynein complex	DNAH7 DYNC1H1	4.12e-03	54	37	2	GO:0030286
MousePheno	abnormal hallux morphology	EIF3C EIF3CL	3.58e-05	5	27	2	MP:0009049
Domain	EIF3C_N_dom	EIF3C EIF3CL	3.61e-06	2	36	2	IPR008905
Domain	eIF-3c_N	EIF3C EIF3CL	3.61e-06	2	36	2	PF05470
Domain	EIF3C	EIF3C EIF3CL	3.61e-06	2	36	2	IPR027516
Domain	EMP70	TM9SF2 TM9SF4	2.16e-05	4	36	2	IPR004240
Domain	EMP70	TM9SF2 TM9SF4	2.16e-05	4	36	2	PF02990
Domain	AAA+_ATPase	ABCA12 DNAH7 VPS4A DYNC1H1	1.65e-04	144	36	4	IPR003593
Domain	AAA	ABCA12 DNAH7 VPS4A DYNC1H1	1.65e-04	144	36	4	SM00382
Domain	Dynein_heavy_chain_D4_dom	DNAH7 DYNC1H1	3.24e-04	14	36	2	IPR024317
Domain	Dynein_HC_stalk	DNAH7 DYNC1H1	3.24e-04	14	36	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH7 DYNC1H1	3.24e-04	14	36	2	IPR013602
Domain	DHC_N2	DNAH7 DYNC1H1	3.24e-04	14	36	2	PF08393
Domain	MT	DNAH7 DYNC1H1	3.24e-04	14	36	2	PF12777
Domain	AAA_8	DNAH7 DYNC1H1	3.24e-04	14	36	2	PF12780
Domain	DHC_fam	DNAH7 DYNC1H1	3.73e-04	15	36	2	IPR026983
Domain	Dynein_heavy_dom	DNAH7 DYNC1H1	3.73e-04	15	36	2	IPR004273
Domain	Dynein_heavy	DNAH7 DYNC1H1	3.73e-04	15	36	2	PF03028
Domain	PINT	EIF3C EIF3CL	4.26e-04	16	36	2	SM00088
Domain	PCI	EIF3C EIF3CL	4.82e-04	17	36	2	PF01399
Domain	PCI_dom	EIF3C EIF3CL	4.82e-04	17	36	2	IPR000717
Domain	TPR-like_helical_dom	ADCY10 GPSM2 IFT122 SMG5	1.02e-03	233	36	4	IPR011990
Domain	zf-RING_2	DZIP3 SYVN1	4.51e-03	52	36	2	PF13639
Domain	P-loop_NTPase	ADCY10 ABCA12 DNAH7 VPS4A DYNC1H1 MYO3B	5.22e-03	848	36	6	IPR027417
Domain	-	ADCY10 GPSM2 IFT122	7.32e-03	207	36	3	1.25.40.10
Domain	-	ADCY10 ABCA12 DNAH7 VPS4A DYNC1H1	1.36e-02	746	36	5	3.40.50.300
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	DZIP3 IFT122 QSER1 TM9SF2 NDUFA9 VPS4A NUP160 DYNC1H1 LPCAT3 RSPH10B EIF3CL	1.07e-07	1321	38	11	27173435
Pubmed	EIF3C Promotes Lung Cancer Tumorigenesis by Regulating the APP/HSPA1A/LMNB1 Axis.	EIF3C EIF3CL	1.16e-06	2	38	2	36157221
Pubmed	Effects of retinal degeneration and brain size upon spatial reversal learning in mice.	PTGER4 PDE6B	3.48e-06	3	38	2	4704351
Pubmed	Nuclear Mitotic Apparatus (NuMA) Interacts with and Regulates Astrin at the Mitotic Spindle.	GPSM2 DYNC1H1	6.96e-06	4	38	2	27462074
Pubmed	Evidence for dynein and astral microtubule-mediated cortical release and transport of Gαi/LGN/NuMA complex in mitotic cells.	GPSM2 DYNC1H1	6.96e-06	4	38	2	23389635
Pubmed	Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies.	EIF3C EIF3CL	6.96e-06	4	38	2	10504338
Pubmed	Cortical dynein is critical for proper spindle positioning in human cells.	GPSM2 DYNC1H1	1.74e-05	6	38	2	23027904
Pubmed	Potential target genes of EMX2 include Odz/Ten-M and other gene families with implications for cortical patterning.	EIF3C DYNC1H1 EIF3CL	2.42e-05	51	38	3	16919471
Pubmed	Comparative analysis of the expression patterns of TM9SF family members in mice.	TM9SF2 TM9SF4	2.43e-05	7	38	2	38719197
Pubmed	The m subunit of murine translation initiation factor eIF3 maintains the integrity of the eIF3 complex and is required for embryonic development, homeostasis, and organ size control.	EIF3C EIF3CL	4.16e-05	9	38	2	24003236
Pubmed	The pleiotropic mouse phenotype extra-toes spotting is caused by translation initiation factor Eif3c mutations and is associated with disrupted sonic hedgehog signaling.	EIF3C EIF3CL	4.16e-05	9	38	2	21292980
Pubmed	mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events.	EIF3C EIF3CL	5.20e-05	10	38	2	16286006
Pubmed	Conservation and diversity of eukaryotic translation initiation factor eIF3.	EIF3C EIF3CL	5.20e-05	10	38	2	8995409
Pubmed	Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3.	EIF3C EIF3CL	7.62e-05	12	38	2	14519125
Pubmed	Reconstitution reveals the functional core of mammalian eIF3.	EIF3C EIF3CL	7.62e-05	12	38	2	17581632
Pubmed	Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3.	EIF3C EIF3CL	1.05e-04	14	38	2	18599441
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH7 DYNC1H1	1.05e-04	14	38	2	9373155
Pubmed	Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry.	EIF3C EIF3CL	1.21e-04	15	38	2	17322308
Pubmed	Mapping the Genetic Landscape of Human Cells.	EIF3C SYVN1 NDUFA9 VPS4A DYNC1H1	1.27e-04	451	38	5	30033366
Pubmed	Controlling tissue patterning by translational regulation of signaling transcripts through the core translation factor eIF3c.	EIF3C EIF3CL	1.56e-04	17	38	2	34752747
Pubmed	EVI1 oncoprotein interacts with a large and complex network of proteins and integrates signals through protein phosphorylation.	KAT2A NUP160 DYNC1H1	3.74e-04	128	38	3	23858473
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	NOL11 EIF3C NDUFA9 VPS4A NUP160 DYNC1H1 EIF3CL	3.74e-04	1257	38	7	37317656
Pubmed	Genetic loci influencing natural variations in femoral bone morphometry in mice.	EIF3C EIF3CL	4.01e-04	27	38	2	11518254
Pubmed	Genome-scale RNAi screen for host factors required for HIV replication.	VPS4A DYNC1H1 RSPH10B SBF2	6.38e-04	361	38	4	18976975
Pubmed	Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC.	EIF3C EIF3CL	7.15e-04	36	38	2	16097034
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	NOL11 EIF3C TM9SF2 VPS4A NUP160 DYNC1H1 EIF3CL	7.90e-04	1425	38	7	30948266
Pubmed	A neurogenomics approach to gene expression analysis in the developing brain.	EIF3C TM9SF4 EIF3CL	8.54e-04	170	38	3	15582152
Pubmed	A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export.	SYVN1 NDUFA9 NUP160 DYNC1H1	8.67e-04	392	38	4	33144569
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DZIP3 SYVN1 DYNC1H1 STRIP2	9.96e-04	407	38	4	12693553
Cytoband	7p22.1	RSPH10B2 RSPH10B	7.04e-04	47	38	2	7p22.1
Cytoband	Ensembl 112 genes in cytogenetic band chr12p13	DYRK4 NDUFA9 LPCAT3	3.12e-03	353	38	3	chr12p13
Cytoband	11q13	UNC93B1 SYVN1	4.33e-03	118	38	2	11q13
GeneFamily	Transmembrane 9 superfamily members	TM9SF2 TM9SF4	1.29e-05	4	27	2	1239
ToppCell	droplet-Lung-LUNG-1m-Myeloid-dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALG8 DYRK4 PTGER4 STRIP2	1.22e-05	167	38	4	e30e7ac8ea4399dc3c1d94fc6b857afc80a7a671
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1-Excitatory_Neuron.Gad1Gad2.Drd1-Cxcl14_(dSPN,_lateral_striatum)-\|Striatum / BrainAtlas - Mouse McCarroll V32	ADCY10 PTGER4 PDE6B	1.84e-05	60	38	3	b3941f8c3cf2365c5bf79961f62c9c0c7405a67b
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1-Excitatory_Neuron.Gad1Gad2.Drd1-Cxcl14_(dSPN,_lateral_striatum)\|Striatum / BrainAtlas - Mouse McCarroll V32	ADCY10 PTGER4 PDE6B	1.84e-05	60	38	3	64d4de1de20d07c5f2e20b76854311a31718faa4
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Cbln1-Excitatory_Neuron.Slc17a7.Reln_(Medial_entorrhinal_cortexm,_Reln+/Cbln1+)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ADCY10 LIPK ABCA12	1.93e-05	61	38	3	5e855b5462f42b7a1d0bbd518cc11072342ce0cc
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Cbln1-Excitatory_Neuron.Slc17a7.Reln_(Medial_entorrhinal_cortexm,_Reln+/Cbln1+)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ADCY10 LIPK ABCA12	1.93e-05	61	38	3	2fc13475581431f82e0b5ef42e18cd29c9787666
ToppCell	(09)_Interm._secr.>cil.\|World / shred by cell type by condition	DZIP3 RSPH10B2 DNAH7 RSPH10B	2.48e-05	200	38	4	3305e14dba12e94da42f0414fdc7a2c8caf0a183
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Cbln1\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ADCY10 LIPK ABCA12	2.93e-05	70	38	3	8d6bdf2e773e894a0db39fdff1fafc2474e03fcf
Disease	retinal degeneration (implicated_via_orthology)	IFT122 PDE6B	7.88e-04	33	37	2	DOID:8466 (implicated_via_orthology)
Disease	Charcot-Marie-Tooth disease	DYNC1H1 SBF2	1.28e-03	42	37	2	cv:C0007959

Protein segments in the cluster

Peptide	Gene	Start	Entry
SLLDDLYKYFFFHHS	CPQ	421	Q9Y646
HTFIRHYKLYQYVLG	C8orf74	116	Q6P047
LHYLNIYNFTYKVFF	ABCA12	641	Q86UK0
IIKAYLDYSLYHHLA	ADCY10	1251	Q96PN6
IQLYSLYHSLHHYKY	QSER1	1666	Q2KHR3
LYHSLHHYKYHVYLI	QSER1	1671	Q2KHR3
YHIKHNILYFLTYAD	KAT2A	601	Q92830
QHITLFLKYLYFLYL	NOL11	611	Q9H8H0
RTFLNYLLHLAYHIY	RSPH10B	491	P0C881
YLLHLAYHIYHEEFQ	RSPH10B	496	P0C881
RTFLNYLLHLAYHIY	RSPH10B2	491	B2RC85
YLLHLAYHIYHEEFQ	RSPH10B2	496	B2RC85
AYFYLHDYAKALEYH	GPSM2	71	P81274
KFYHFQRLAELYHGY	IFT122	941	Q9HBG6
EFNLYYLKFLAFHYV	SBF2	1491	Q86WG5
LEFYLHIHFAIYLLK	ARMC9	96	Q7Z3E5
INHAYFYSHYVDKRL	PTGER4	121	P35408
ATLYLKIYHLSYLHN	PDE6B	216	P35913
YLFYKETYLIHLFHT	LPCAT3	61	Q6P1A2
YLLFHLVKYIFAVAH	NDUFA9	271	Q16795
FKLDYNYFYHLLHII	DZIP3	386	Q86Y13
RILHTYYKFDYKAHQ	EIF3C	506	Q99613
FYLKVLHDHIAYRYE	DYRK4	91	Q9NR20
LRILHTYYKFDYKAH	EIF3CL	506	B5ME19
AIEKDILRYYYYIHH	DNAH7	156	Q8WXX0
YLDFINHYANLFHEK	DYNC1H1	3176	Q14204
HAYYLKHQFYPTVVY	SYVN1	21	Q86TM6
FYQHLLLYIQSHYQL	SMG5	121	Q9UPR3
LLKHFKLNHIYQFEY	STRIP2	581	Q9ULQ0
FDYDYTLVFYSKHLH	NT5DC3	101	Q86UY8
MTHNYYELLYAFHIY	NUP160	1076	Q12769
LFAVLLHFKHIYLYV	ALG8	191	Q9BVK2
HKKYFALGLLYHYNN	TGFBRAP1	486	Q8WUH2
YFLNHYLYDLNHTLY	UNC93B1	241	Q9H1C4
KIYLHNHLSFILYYH	TM9SF4	176	Q92544
YLLTYKFSHDHLELF	THAP9	601	Q9H5L6
FYIFNHVDIKIYYHV	TM9SF2	206	Q99805
VYFLIYAVHYFFSKL	TM9SF2	601	Q99805
LYQHAVEYFLHAIKY	VPS4A	31	Q9UN37
LIYYKLIPHYNHVDF	LIPK	361	Q5VXJ0
ERSFHFKYLHYYLTS	ART4	151	Q93070
FHIFYYIYAGLHHQK	MYO3B	531	Q8WXR4