Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	inositol 1,4,5-trisphosphate-gated calcium channel activity	ITPR1 ITPR2	8.99e-05	3	110	2	GO:0005220
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	TRPM2 ITPR1 ITPR2	1.25e-04	18	110	3	GO:0015278
GeneOntologyMolecularFunction	L27 domain binding	LIN7C LIN7A	1.79e-04	4	110	2	GO:0097016
GeneOntologyMolecularFunction	indanol dehydrogenase activity	AKR1B10 AKR1B15	1.79e-04	4	110	2	GO:0047718
GeneOntologyMolecularFunction	allyl-alcohol dehydrogenase activity	AKR1B10 AKR1B15	1.79e-04	4	110	2	GO:0047655
GeneOntologyMolecularFunction	H3K27me3 modified histone binding	TAF1 TAF1L	2.97e-04	5	110	2	GO:0061628
GeneOntologyMolecularFunction	geranylgeranyl reductase activity	AKR1B10 AKR1B15	4.45e-04	6	110	2	GO:0045550
GeneOntologyMolecularFunction	monoatomic cation channel activity	ASIC1 TRPM2 GRIK3 ITPR1 ITPR2 KCNE1 PKD1 UNC80	6.26e-04	343	110	8	GO:0005261
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	TRPM2 ITPR1 ITPR2	6.53e-04	31	110	3	GO:0099604
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	TRPM2 ITPR1 ITPR2	7.87e-04	33	110	3	GO:0005217
GeneOntologyMolecularFunction	monoatomic ion channel activity	ASIC1 TRPM2 GRIK3 ITPR1 ITPR2 KCNE1 PKD1 TMEM150C UNC80	9.91e-04	459	110	9	GO:0005216
GeneOntologyMolecularFunction	transcription regulator inhibitor activity	PKD1 TAF1 TAF1L	1.02e-03	36	110	3	GO:0140416
GeneOntologyMolecularFunction	RNA polymerase I general transcription initiation factor activity	TAF1 TAF1L	1.06e-03	9	110	2	GO:0001181
GeneOntologyMolecularFunction	NADP+ binding	AKR1B10 AKR1B15	1.06e-03	9	110	2	GO:0070401
GeneOntologyMolecularFunction	ligand-gated monoatomic cation channel activity	ASIC1 TRPM2 GRIK3 ITPR1 ITPR2	1.07e-03	140	110	5	GO:0099094
GeneOntologyCellularComponent	synaptic membrane	HIP1 LIN7C COMT NRCAM GPER1 ASIC1 GRIK3 LIN7A ITPR1 GPC4 UNC13C DAGLA	5.79e-05	583	110	12	GO:0097060
GeneOntologyCellularComponent	postsynaptic density	LIN7C NRCAM GPER1 ASIC1 CAMK2A GRIK3 ADD1 LIN7A ITPR1 DAGLA	1.36e-04	451	110	10	GO:0014069
GeneOntologyCellularComponent	postsynaptic density membrane	LIN7C NRCAM ASIC1 GRIK3 LIN7A DAGLA	1.84e-04	157	110	6	GO:0098839
GeneOntologyCellularComponent	asymmetric synapse	LIN7C NRCAM GPER1 ASIC1 CAMK2A GRIK3 ADD1 LIN7A ITPR1 DAGLA	2.13e-04	477	110	10	GO:0032279
GeneOntologyCellularComponent	MPP7-DLG1-LIN7 complex	LIN7C LIN7A	2.72e-04	5	110	2	GO:0097025
GeneOntologyCellularComponent	postsynapse	HIP1 LIN7C COMT NRCAM GPER1 ASIC1 CAMK2A USP9X GRIK3 ADD1 LIN7A ITPR1 UBE3A NGEF DAGLA	2.86e-04	1018	110	15	GO:0098794
GeneOntologyCellularComponent	postsynaptic membrane	HIP1 LIN7C COMT NRCAM GPER1 ASIC1 GRIK3 LIN7A DAGLA	2.92e-04	405	110	9	GO:0045211
GeneOntologyCellularComponent	postsynaptic specialization	LIN7C NRCAM GPER1 ASIC1 CAMK2A GRIK3 ADD1 LIN7A ITPR1 DAGLA	3.25e-04	503	110	10	GO:0099572
GeneOntologyCellularComponent	neuron to neuron synapse	LIN7C NRCAM GPER1 ASIC1 CAMK2A GRIK3 ADD1 LIN7A ITPR1 DAGLA	4.42e-04	523	110	10	GO:0098984
GeneOntologyCellularComponent	mitotic cohesin complex	STAG1 STAG2	5.66e-04	7	110	2	GO:0030892
GeneOntologyCellularComponent	postsynaptic specialization membrane	LIN7C NRCAM ASIC1 GRIK3 LIN7A DAGLA	6.86e-04	201	110	6	GO:0099634
GeneOntologyCellularComponent	axon	COMT NRCAM GPER1 CAMK2A USP9X GRIK3 DSCAML1 ITPR2 NGEF UNC13C NRSN1 DAGLA UNC80	8.16e-04	891	110	13	GO:0030424
GeneOntologyCellularComponent	adherens junction	LIN7C LIMD1 ADD1 LIN7A WTIP JAG1	9.05e-04	212	110	6	GO:0005912
GeneOntologyCellularComponent	platelet dense tubular network membrane	ITPR1 ITPR2	9.64e-04	9	110	2	GO:0031095
GeneOntologyCellularComponent	cytoplasmic vesicle membrane	ENTPD7 HIP1 LIN7C GPER1 CAMK2A TRPM2 SPPL2B LIN7A ITPR1 ITPR2 YKT6 TMEM184A WNT3A PKD1 UNC13C DAGLA	1.33e-03	1307	110	16	GO:0030659
GeneOntologyCellularComponent	cohesin complex	STAG1 STAG2	1.46e-03	11	110	2	GO:0008278
GeneOntologyCellularComponent	platelet dense tubular network	ITPR1 ITPR2	1.46e-03	11	110	2	GO:0031094
GeneOntologyCellularComponent	vesicle membrane	ENTPD7 HIP1 LIN7C GPER1 CAMK2A TRPM2 SPPL2B LIN7A ITPR1 ITPR2 YKT6 TMEM184A WNT3A PKD1 UNC13C DAGLA	1.53e-03	1325	110	16	GO:0012506
GeneOntologyCellularComponent	dendritic spine	COMT GPER1 ASIC1 CAMK2A ADD1 DAGLA	1.78e-03	242	110	6	GO:0043197
GeneOntologyCellularComponent	transcription factor TFIID complex	ERCC2 TAF1 TAF1L	1.94e-03	47	110	3	GO:0005669
GeneOntologyCellularComponent	neuron spine	COMT GPER1 ASIC1 CAMK2A ADD1 DAGLA	1.97e-03	247	110	6	GO:0044309
GeneOntologyCellularComponent	presynapse	HIP1 LIN7C GPER1 ASIC1 CAMK2A GRIK3 LIN7A ITPR1 UBE3A WNT3A GPC4 UNC13C	2.43e-03	886	110	12	GO:0098793
GeneOntologyCellularComponent	cell cortex	HIP1 WDPCP ITPR2 FRY UNC13C NLRP4 SPINK5	3.50e-03	371	110	7	GO:0005938
HumanPheno	Prominent nose	ERCC2 USP9X ITPR1 GPC4 FGF3 STAG2 UNC80	1.57e-05	110	39	7	HP:0000448
HumanPheno	Abnormality of the palpebral fissures	COMT NRCAM CAMK2A USP9X FANCM WDPCP ITPR1 BMP1 SETD2 SATB1 UBE3A NUP37 JAG1 GPC4 FGF3 TAF1 STAG2 UNC80	2.59e-05	880	39	18	HP:0008050
HumanPheno	Slanting of the palpebral fissure	COMT NRCAM CAMK2A USP9X FANCM WDPCP ITPR1 SETD2 SATB1 UBE3A NUP37 JAG1 GPC4 FGF3 TAF1 UNC80	4.69e-05	739	39	16	HP:0200006
HumanPheno	Abnormal facial shape	PCYT1A ERCC2 ADAMTSL1 COMT NRCAM STAG1 USP9X TSHR KDM6B FANCM ITPR1 BMP1 SETD2 UBE3A JAG1 GPC4 USP7 FGF3 TAF1 STAG2 UNC80	5.24e-05	1221	39	21	HP:0001999
Domain	BMP_1/tolloid-like	BMP1 TLL1 TLL2	1.83e-07	3	107	3	IPR015446
Domain	Peptidase_M12A	BMP1 TLL1 TLL2	3.61e-06	6	107	3	IPR001506
Domain	Astacin	BMP1 TLL1 TLL2	3.61e-06	6	107	3	PF01400
Domain	CUB	OVCH1 BMP1 TLL1 TLL2 DCBLD2	8.76e-06	49	107	5	PF00431
Domain	CUB	OVCH1 BMP1 TLL1 TLL2 DCBLD2	9.69e-06	50	107	5	SM00042
Domain	-	OVCH1 BMP1 TLL1 TLL2 DCBLD2	1.18e-05	52	107	5	2.60.120.290
Domain	CUB	OVCH1 BMP1 TLL1 TLL2 DCBLD2	1.30e-05	53	107	5	PS01180
Domain	CUB_dom	OVCH1 BMP1 TLL1 TLL2 DCBLD2	1.86e-05	57	107	5	IPR000859
Domain	ARM-type_fold	HIP1 STAG1 USP9X XPO4 ITPR1 ITPR2 DOCK5 CNOT9 PIK3C2B STAG2	2.51e-05	339	107	10	IPR016024
Domain	TFIID_sub1_DUF3591	TAF1 TAF1L	3.25e-05	2	107	2	IPR022591
Domain	TBP-binding	TAF1 TAF1L	3.25e-05	2	107	2	PF09247
Domain	DUF3591	TAF1 TAF1L	3.25e-05	2	107	2	PF12157
Domain	TAF_II_230-bd	TAF1 TAF1L	3.25e-05	2	107	2	IPR009067
Domain	-	TAF1 TAF1L	3.25e-05	2	107	2	1.10.1100.10
Domain	TAF1_animal	TAF1 TAF1L	3.25e-05	2	107	2	IPR011177
Domain	InsP3_rcpt-bd	ITPR1 ITPR2	9.72e-05	3	107	2	IPR000493
Domain	EGF_CA	SVEP1 BMP1 TLL1 TLL2 JAG1	1.35e-04	86	107	5	PF07645
Domain	SCD	STAG1 STAG2	1.94e-04	4	107	2	PS51425
Domain	SCD	STAG1 STAG2	1.94e-04	4	107	2	IPR020839
Domain	STAG	STAG1 STAG2	1.94e-04	4	107	2	PF08514
Domain	STAG	STAG1 STAG2	1.94e-04	4	107	2	IPR013721
Domain	EGF_Ca-bd_CS	SVEP1 BMP1 TLL1 TLL2 JAG1	2.38e-04	97	107	5	IPR018097
Domain	EGF_CA	SVEP1 BMP1 TLL1 TLL2 JAG1	2.62e-04	99	107	5	PS01187
Domain	WSC	WSCD1 PKD1	3.22e-04	5	107	2	SM00321
Domain	WSC	WSCD1 PKD1	3.22e-04	5	107	2	PS51212
Domain	WSC_carb-bd	WSCD1 PKD1	3.22e-04	5	107	2	IPR002889
Domain	WSC	WSCD1 PKD1	3.22e-04	5	107	2	PF01822
Domain	EGF-type_Asp/Asn_hydroxyl_site	SVEP1 BMP1 TLL1 TLL2 JAG1	3.60e-04	106	107	5	IPR000152
Domain	RIH_assoc-dom	ITPR1 ITPR2	4.80e-04	6	107	2	IPR013662
Domain	Ins145_P3_rec	ITPR1 ITPR2	4.80e-04	6	107	2	PF08709
Domain	RIH_assoc	ITPR1 ITPR2	4.80e-04	6	107	2	PF08454
Domain	RIH_dom	ITPR1 ITPR2	4.80e-04	6	107	2	IPR000699
Domain	Ins145_P3_rcpt	ITPR1 ITPR2	4.80e-04	6	107	2	IPR014821
Domain	Ryanodine_recept-rel	ITPR1 ITPR2	4.80e-04	6	107	2	IPR015925
Domain	-	ITPR1 ITPR2	4.80e-04	6	107	2	1.25.10.30
Domain	RYDR_ITPR	ITPR1 ITPR2	4.80e-04	6	107	2	PF01365
Domain	Peptidase_Metallo	BMP1 TLL1 TLL2	5.99e-04	29	107	3	IPR006026
Domain	ZnMc	BMP1 TLL1 TLL2	5.99e-04	29	107	3	SM00235
Domain	EGF_CA	SVEP1 BMP1 TLL1 TLL2 JAG1	6.85e-04	122	107	5	SM00179
Domain	EGF-like_Ca-bd_dom	SVEP1 BMP1 TLL1 TLL2 JAG1	7.37e-04	124	107	5	IPR001881
Domain	EGF	SVEP1 BMP1 TLL1 TLL2 JAG1	7.92e-04	126	107	5	PF00008
Domain	MIR	ITPR1 ITPR2	1.42e-03	10	107	2	PF02815
Domain	L27_C	LIN7C LIN7A	1.42e-03	10	107	2	IPR014775
Domain	ALDOKETO_REDUCTASE_1	AKR1B10 AKR1B15	1.42e-03	10	107	2	PS00798
Domain	MIR_motif	ITPR1 ITPR2	1.42e-03	10	107	2	IPR016093
Domain	L27	LIN7C LIN7A	1.42e-03	10	107	2	PF02828
Domain	ALDOKETO_REDUCTASE_2	AKR1B10 AKR1B15	1.42e-03	10	107	2	PS00062
Domain	ALDOKETO_REDUCTASE_3	AKR1B10 AKR1B15	1.42e-03	10	107	2	PS00063
Domain	MIR	ITPR1 ITPR2	1.42e-03	10	107	2	PS50919
Domain	MIR	ITPR1 ITPR2	1.42e-03	10	107	2	SM00472
Domain	Aldo/ket_reductase_CS	AKR1B10 AKR1B15	1.42e-03	10	107	2	IPR018170
Domain	Aldo/keto_reductase	AKR1B10 AKR1B15	1.42e-03	10	107	2	IPR020471
Domain	L27	LIN7C LIN7A	2.43e-03	13	107	2	SM00569
Domain	L27	LIN7C LIN7A	2.43e-03	13	107	2	PS51022
Domain	L27_dom	LIN7C LIN7A	2.43e-03	13	107	2	IPR004172
Domain	ZINC_PROTEASE	LVRN BMP1 TLL1 TLL2	2.43e-03	98	107	4	PS00142
Domain	Post-SET_dom	SETDB1 SETD2	3.70e-03	16	107	2	IPR003616
Domain	PostSET	SETDB1 SETD2	3.70e-03	16	107	2	SM00508
Domain	-	AKR1B10 AKR1B15	3.70e-03	16	107	2	3.20.20.100
Domain	POST_SET	SETDB1 SETD2	3.70e-03	16	107	2	PS50868
Domain	NADP_OxRdtase_dom	AKR1B10 AKR1B15	4.18e-03	17	107	2	IPR023210
Domain	Aldo_ket_red	AKR1B10 AKR1B15	4.18e-03	17	107	2	PF00248
Domain	Aldo/ket_red/Kv-b	AKR1B10 AKR1B15	4.18e-03	17	107	2	IPR001395
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	PCYT1A NRCAM STAG1 CAMK2A USP9X CMYA5 KDM6B DSCAML1 DCAF5 SETDB1 ZNF836 FRY SATB1 UBE3A GEMIN8 PKD1 NGEF USP7 CCAR1 TAF1	4.25e-09	1285	111	20	35914814
Pubmed	Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases.	BMP1 TLL1 TLL2	3.16e-08	3	111	3	18824173
Pubmed	Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis.	BMP1 TLL1 TLL2	3.15e-07	5	111	3	10479448
Pubmed	New nomenclature for chromatin-modifying enzymes.	KDM6B SETDB1 SETD2 TAF1 TAF1L	1.11e-06	57	111	5	18022353
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	SART3 HIP1 ERCC2 USP9X PCMTD1 SETDB1 PIK3C2B UBE3A GPC4 PDP2	3.46e-06	481	111	10	28190767
Pubmed	TRPM2 and CaMKII Signaling Drives Excessive GABAergic Synaptic Inhibition Following Ischemia.	CAMK2A TRPM2	1.01e-05	2	111	2	38565288
Pubmed	Role of AKR1B10 and AKR1B8 in the pathogenesis of non-alcoholic steatohepatitis (NASH) in mouse.	AKR1B10 AKR1B15	1.01e-05	2	111	2	34954342
Pubmed	STAG Mutations in Cancer.	STAG1 STAG2	1.01e-05	2	111	2	31421907
Pubmed	The occurrence of lupus nephritis is regulated by USP7-mediated JMJD3 stabilization.	KDM6B USP7	1.01e-05	2	111	2	33895173
Pubmed	Distinct and overlapping roles of STAG1 and STAG2 in cohesin localization and gene expression in embryonic stem cells.	STAG1 STAG2	1.01e-05	2	111	2	32778134
Pubmed	Aldo-keto reductase family 1 member B8 is secreted via non-classical pathway.	AKR1B10 AKR1B15	1.01e-05	2	111	2	25120755
Pubmed	Murine aldo-keto reductase family 1 subfamily B: identification of AKR1B8 as an ortholog of human AKR1B10.	AKR1B10 AKR1B15	1.01e-05	2	111	2	21087085
Pubmed	Tissue-specific expression of two aldose reductase-like genes in mice: abundant expression of mouse vas deferens protein and fibroblast growth factor-regulated protein in the adrenal gland.	AKR1B10 AKR1B15	1.01e-05	2	111	2	8526877
Pubmed	AKR1B8 deficiency drives severe DSS-induced acute colitis through invasion of luminal bacteria and activation of innate immunity.	AKR1B10 AKR1B15	1.01e-05	2	111	2	36518763
Pubmed	Nuclear import and export signals of human cohesins SA1/STAG1 and SA2/STAG2 expressed in Saccharomyces cerevisiae.	STAG1 STAG2	1.01e-05	2	111	2	22715410
Pubmed	Synthetic lethal interaction between the tumour suppressor STAG2 and its paralog STAG1.	STAG1 STAG2	1.01e-05	2	111	2	28430577
Pubmed	Immunolocalization of type 2 inositol 1,4,5-trisphosphate receptors in cardiac myocytes from newborn mice.	ITPR1 ITPR2	1.01e-05	2	111	2	15201137
Pubmed	Sulphide signalling potentiates apoptosis through the up-regulation of IP3 receptor types 1 and 2.	ITPR1 ITPR2	1.01e-05	2	111	2	23582047
Pubmed	Skeletal muscle expression of bone morphogenetic protein-1 and tolloid-like-1 extracellular proteases in different fiber types and in response to unloading, food deprivation and differentiation.	BMP1 TLL1	1.01e-05	2	111	2	20658214
Pubmed	Impaired Barrier Function and Immunity in the Colon of Aldo-Keto Reductase 1B8 Deficient Mice.	AKR1B10 AKR1B15	1.01e-05	2	111	2	33644071
Pubmed	Taf1 knockout is lethal in embryonic male mice and heterozygous females show weight and movement disorders.	TAF1 TAF1L	1.01e-05	2	111	2	38804708
Pubmed	Distinct functions of human cohesin-SA1 and cohesin-SA2 in double-strand break repair.	STAG1 STAG2	1.01e-05	2	111	2	24324008
Pubmed	Sustained expression of a neuron-specific isoform of the Taf1 gene in development stages and aging in mice.	TAF1 TAF1L	1.01e-05	2	111	2	22842574
Pubmed	Bone morphogenetic protein-1 and a mammalian tolloid homologue (mTld) are encoded by alternatively spliced transcripts which are differentially expressed in some tissues.	BMP1 TLL1	1.01e-05	2	111	2	7798260
Pubmed	Frameshift Mutations in the Mononucleotide Repeats of TAF1 and TAF1L Genes in Gastric and Colorectal Cancers with Regional Heterogeneity.	TAF1 TAF1L	1.01e-05	2	111	2	27571988
Pubmed	Striatal Cholinergic Dysregulation after Neonatal Decrease in X-Linked Dystonia Parkinsonism-Related TAF1 Isoforms.	TAF1 TAF1L	1.01e-05	2	111	2	34403156
Pubmed	MiR-218-5p promotes trophoblast infiltration and inhibits endoplasmic reticulum/oxidative stress by reducing UBE3A-mediated degradation of SATB1.	SATB1 UBE3A	1.01e-05	2	111	2	37191839
Pubmed	Functional expression of novel human and murine AKR1B genes.	AKR1B10 AKR1B15	1.01e-05	2	111	2	21276782
Pubmed	Type 1 and 2 IP3 receptors respond differently to catecholamines and stress.	ITPR1 ITPR2	1.01e-05	2	111	2	19120126
Pubmed	Compensatory upregulation of aldo-keto reductase 1B10 to protect hepatocytes against oxidative stress during hepatocarcinogenesis.	AKR1B10 AKR1B15	1.01e-05	2	111	2	31911858
Pubmed	STAG2 loss-of-function affects short-range genomic contacts and modulates the basal-luminal transcriptional program of bladder cancer cells.	STAG1 STAG2	1.01e-05	2	111	2	34648034
Pubmed	Characterization of a novel gene product (mammalian tolloid-like) with high sequence similarity to mammalian tolloid/bone morphogenetic protein-1.	BMP1 TLL1	1.01e-05	2	111	2	8661043
Pubmed	Upregulation of deubiquitinase USP7 by transcription factor FOXO6 promotes EC progression via targeting the JMJD3/CLU axis.	KDM6B USP7	1.01e-05	2	111	2	33768140
Pubmed	Inactivation of bone morphogenetic protein 1 (Bmp1) and tolloid-like 1 (Tll1) in cells expressing type I collagen leads to dental and periodontal defects in mice.	BMP1 TLL1	1.01e-05	2	111	2	28000152
Pubmed	Somatic mutation of the cohesin complex subunit confers therapeutic vulnerabilities in cancer.	STAG1 STAG2	1.01e-05	2	111	2	29649003
Pubmed	Ubiquitin-specific protease 9X in host cells interacts with herpes simplex virus 1 ICP0.	USP9X USP7	1.01e-05	2	111	2	26596467
Pubmed	An antidepressant behaviour in mice carrying a gene-specific InsP3R1, InsP3R2 and InsP3R3 protein knockdown.	ITPR1 ITPR2	1.01e-05	2	111	2	18708078
Pubmed	Synergistic effects of the dopaminergic and glutamatergic system on hippocampal volume in alcohol-dependent patients.	COMT GRIK3	1.01e-05	2	111	2	18423838
Pubmed	Cohesin subunits, STAG1 and STAG2, and cohesin regulatory factor, PDS5b, in oral squamous cells carcinomas.	STAG1 STAG2	1.01e-05	2	111	2	27341316
Pubmed	1.7 A structure of FR-1, a fibroblast growth factor-induced member of the aldo-keto reductase family, complexed with coenzyme and inhibitor.	AKR1B10 AKR1B15	1.01e-05	2	111	2	7578036
Pubmed	Characterization of the promoter of the gene for a mouse vas deferens protein related to the aldo-keto reductase superfamily: effect of steroid hormones and phorbol esters.	AKR1B10 AKR1B15	1.01e-05	2	111	2	8541228
Pubmed	Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts.	STAG1 STAG2	1.01e-05	2	111	2	28691904
Pubmed	Ubiquitin becomes ubiquitous in cancer: emerging roles of ubiquitin ligases and deubiquitinases in tumorigenesis and as therapeutic targets.	UBE3A USP7	1.01e-05	2	111	2	20930542
Pubmed	Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres.	STAG1 STAG2	1.01e-05	2	111	2	22415365
Pubmed	Proteinase bone morphogenetic protein 1, but not tolloid-like 1, plays a dominant role in maintaining periodontal homeostasis.	BMP1 TLL1	1.01e-05	2	111	2	33169406
Pubmed	Downregulation of dual-specificity tyrosine-regulated kinase 2 promotes tumor cell proliferation and invasion by enhancing cyclin-dependent kinase 14 expression in breast cancer.	CDK14 DYRK2	1.01e-05	2	111	2	29193658
Pubmed	TAFII250, Egr-1, and D-type cyclin expression in mice and neonatal rat cardiomyocytes treated with doxorubicin.	TAF1 TAF1L	1.01e-05	2	111	2	10070062
Pubmed	Differential regulation of telomere and centromere cohesion by the Scc3 homologues SA1 and SA2, respectively, in human cells.	STAG1 STAG2	1.01e-05	2	111	2	19822671
Pubmed	Polymorphisms of COMT and XPD and risk of esophageal squamous cell carcinoma in a population of Yili Prefecture, in Xinjiang, China.	ERCC2 COMT	1.01e-05	2	111	2	20979431
Pubmed	Intrinsic flexibility of NLRP pyrin domains is a key factor in their conformational dynamics, fold stability, and dimerization.	NLRP14 NLRP4	1.01e-05	2	111	2	25403012
Pubmed	The miRNA-15b/USP7/KDM6B axis engages in the initiation of osteoporosis by modulating osteoblast differentiation and autophagy.	KDM6B USP7	1.01e-05	2	111	2	33434305
Pubmed	Impaired self-renewal and increased colitis and dysplastic lesions in colonic mucosa of AKR1B8-deficient mice.	AKR1B10 AKR1B15	1.01e-05	2	111	2	25538260
Pubmed	STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers.	STAG1 STAG2	1.01e-05	2	111	2	32467316
Pubmed	Specialized functions of cohesins STAG1 and STAG2 in 3D genome architecture.	STAG1 STAG2	1.01e-05	2	111	2	32294612
Pubmed	Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation.	STAG1 STAG2	1.01e-05	2	111	2	31495782
Pubmed	Phosphatidylinositol-3-kinase C2β and TRIM27 function to positively and negatively regulate IgE receptor activation of mast cells.	TRIM27 PIK3C2B	1.01e-05	2	111	2	22645315
Pubmed	Rescue of neurological deficits in a mouse model for Angelman syndrome by reduction of alphaCaMKII inhibitory phosphorylation.	CAMK2A UBE3A	1.01e-05	2	111	2	17259980
Pubmed	Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast cultures.	TLL1 TLL2	1.01e-05	2	111	2	11313359
Pubmed	Characterization of vertebrate cohesin complexes and their regulation in prophase.	STAG1 CDC16 STAG2	1.12e-05	14	111	3	11076961
Pubmed	PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase.	SART3 USP9X TRIM27 SETD2 FRY CNOT9 CDC16	1.52e-05	247	111	7	32989298
Pubmed	Lesson from the stoichiometry determination of the cohesin complex: a short protease mediated elution increases the recovery from cross-linked antibody-conjugated beads.	STAG1 CDC16 STAG2	2.08e-05	17	111	3	21043528
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	CYC1 SART3 HIP1 ERCC2 LIN7C TRIM27 SQOR SETD2 CNOT9 NUP37 CDC16 USP7 CCAR1 TAF1L STAG2 ZNF574	2.21e-05	1497	111	16	31527615
Pubmed	Multidimensional Proteomics Reveals a Role of UHRF2 in the Regulation of Epithelial-Mesenchymal Transition (EMT).	ERCC2 CDC16 USP7 ZNF574	2.96e-05	55	111	4	27114453
Pubmed	The mouse germ-cell-specific leucine-rich repeat protein NALP14: a member of the NACHT nucleoside triphosphatase family.	NLRP14 NLRP4	3.02e-05	3	111	2	15590904
Pubmed	Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.	ITPR1 ITPR2	3.02e-05	3	111	2	10874040
Pubmed	Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy-derived cells.	ITPR1 ITPR2	3.02e-05	3	111	2	20395455
Pubmed	Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases.	ITPR1 ITPR2	3.02e-05	3	111	2	17437169
Pubmed	Tension-dependent regulation of mammalian Hippo signaling through LIMD1.	LIMD1 WTIP	3.02e-05	3	111	2	29440237
Pubmed	Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors.	ITPR1 ITPR2	3.02e-05	3	111	2	18547250
Pubmed	Inositol 1,4,5-trisphosphate receptor gene variants are related to the risk of breast cancer in a Chinese population.	ITPR1 ITPR2	3.02e-05	3	111	2	36350267
Pubmed	Use of Bmp1/Tll1 doubly homozygous null mice and proteomics to identify and validate in vivo substrates of bone morphogenetic protein 1/tolloid-like metalloproteinases.	BMP1 TLL1	3.02e-05	3	111	2	12808086
Pubmed	Inositol 1,4,5-trisphosphate receptors are essential for fetal-maternal connection and embryo viability.	ITPR1 ITPR2	3.02e-05	3	111	2	32320395
Pubmed	BMP1 and TLL1 Are Required for Maintaining Periodontal Homeostasis.	BMP1 TLL1	3.02e-05	3	111	2	28068493
Pubmed	The versatility and universality of calcium signalling.	ITPR1 ITPR2	3.02e-05	3	111	2	11413485
Pubmed	Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors.	ITPR1 ITPR2	3.02e-05	3	111	2	26009177
Pubmed	Characterization of the interaction between the cohesin subunits Rad21 and SA1/2.	STAG1 STAG2	3.02e-05	3	111	2	23874961
Pubmed	Substrate specificity and catalytic efficiency of aldo-keto reductases with phospholipid aldehydes.	AKR1B10 AKR1B15	3.02e-05	3	111	2	17381426
Pubmed	Precise Spatiotemporal Control of Nodal Na+ Channel Clustering by Bone Morphogenetic Protein-1/Tolloid-like Proteinases.	BMP1 TLL1	3.02e-05	3	111	2	32209430
Pubmed	Receptor-activated single channels in intact human platelets.	ITPR1 ITPR2	3.02e-05	3	111	2	1693919
Pubmed	Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.	ITPR1 ITPR2	3.02e-05	3	111	2	23955339
Pubmed	Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells.	ITPR1 ITPR2	3.02e-05	3	111	2	31979185
Pubmed	Polycystin-1 interacts with inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling with implications for polycystic kidney disease.	ITPR1 PKD1	3.02e-05	3	111	2	19854836
Pubmed	Dissociation of locomotor and cerebellar deficits in a murine Angelman syndrome model.	CAMK2A UBE3A	3.02e-05	3	111	2	26485287
Pubmed	Tsg101 regulates PI(4,5)P2/Ca(2+) signaling for HIV-1 Gag assembly.	ITPR1 ITPR2	3.02e-05	3	111	2	24904548
Pubmed	A delayed-early gene activated by fibroblast growth factor-1 encodes a protein related to aldose reductase.	AKR1B10 AKR1B15	3.02e-05	3	111	2	7510692
Pubmed	Bone morphogenetic protein-1 processes probiglycan.	BMP1 TLL1	3.02e-05	3	111	2	10896944
Pubmed	Genetic analysis of the role of proteolysis in the activation of latent myostatin.	BMP1 TLL2	3.02e-05	3	111	2	18286185
Pubmed	Induced ablation of Bmp1 and Tll1 produces osteogenesis imperfecta in mice.	BMP1 TLL1	3.02e-05	3	111	2	24419319
Pubmed	Differential distribution of inositol trisphosphate receptor isoforms in mouse oocytes.	ITPR1 ITPR2	3.02e-05	3	111	2	9858485
Pubmed	Essential Roles of Bone Morphogenetic Protein-1 and Mammalian Tolloid-like 1 in Postnatal Root Dentin Formation.	BMP1 TLL1	3.02e-05	3	111	2	27847137
Pubmed	Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization.	ITPR1 ITPR2	3.02e-05	3	111	2	9808793
Pubmed	CaMKII regulates diacylglycerol lipase-α and striatal endocannabinoid signaling.	CAMK2A DAGLA	3.02e-05	3	111	2	23502535
Pubmed	Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2β.	TRIM27 PIK3C2B	3.02e-05	3	111	2	22128329
Pubmed	Single-molecule imaging reveals a direct role of CTCF's zinc fingers in SA interaction and cluster-dependent RNA recruitment.	STAG1 STAG2	3.02e-05	3	111	2	38742641
Pubmed	Mutations in the cohesin complex in acute myeloid leukemia: clinical and prognostic implications.	STAG1 STAG2	3.02e-05	3	111	2	24335498
Pubmed	USP7-TRIM27 axis negatively modulates antiviral type I IFN signaling.	TRIM27 USP7	3.02e-05	3	111	2	29688809
Pubmed	Type 2 and type 3 inositol 1,4,5-trisphosphate (IP3) receptors promote the differentiation of granule cell precursors in the postnatal cerebellum.	ITPR1 ITPR2	3.02e-05	3	111	2	18194433
Pubmed	Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction.	BMP1 TLL1	3.02e-05	3	111	2	19079247
Pubmed	Regulated expression of TAF1 in 1-cell mouse embryos.	TAF1 TAF1L	3.02e-05	3	111	2	16822332
Pubmed	IP3 receptors regulate vascular smooth muscle contractility and hypertension.	ITPR1 ITPR2	3.02e-05	3	111	2	27777977
Interaction	SFRP2 interactions	ZMYND19 BMP1 TLL1 WNT3A CCAR1	1.10e-06	35	107	5	int:SFRP2
GeneFamily	Bone morphogenetic proteins\|Astacins	BMP1 TLL1 TLL2	1.47e-06	6	77	3	894
GeneFamily	Inositol 1,4,5-triphosphate receptors\|Protein phosphatase 1 regulatory subunits	ITPR1 ITPR2	5.36e-05	3	77	2	297
GeneFamily	Cohesin complex	STAG1 STAG2	4.93e-04	8	77	2	1060
GeneFamily	PDZ domain containing\|Crumbs complex	LIN7C LIN7A	6.32e-04	9	77	2	1223
GeneFamily	Aldo-keto reductases	AKR1B10 AKR1B15	1.81e-03	15	77	2	399
GeneFamily	NLR family	NLRP14 NLRP4	5.04e-03	25	77	2	666
GeneFamily	Pyrin domain containing\|Pyrin and HIN domain family	NLRP14 NLRP4	5.04e-03	25	77	2	994
GeneFamily	Cyclin dependent kinases	CDK14 CDKL1	5.45e-03	26	77	2	496
ToppCell	Bronchial_Brush-Epithelial-Ionocytes\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	NRCAM GPER1 TRPM2 PLPPR1 LHX9 ITPR2 UNC13C	2.36e-07	173	109	7	e1de849dcd96063136bdac87e050ddbd55cabdcc
ToppCell	Bronchial_Brush-Epithelial-Ionocytes\|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	NRCAM GPER1 TRPM2 PLPPR1 LHX9 ITPR2 UNC13C	2.36e-07	173	109	7	f2a8f4918c1fb68d98bc3f33cd624de0f0f11e06
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	HIP1 NRCAM PLPPR1 CDKL1 ITPR1 ITPR2 NINL	3.45e-07	183	109	7	31ab55d5f3639f5964541d5eae23044dbda3356e
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	HIP1 NRCAM PLPPR1 CDKL1 ITPR1 ITPR2 NINL	3.71e-07	185	109	7	898a093757f86be3e18d2ef1f16a71f50ef81dc3
ToppCell	PSB-critical-LOC-Epithelial-Ionocyte\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	WSCD1 NRCAM GPER1 TRPM2 PLPPR1 ITPR2 UNC13C	4.60e-07	191	109	7	8f4637e801554e2343b974fe7794f01dd2151418
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NRCAM CDK14 ITPR1 FRY UBE3A PKD1 UNC80	5.86e-07	198	109	7	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSCAML1 SVEP1 LIN7A TLL1 HYDIN UNC80	2.76e-06	160	109	6	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSCAML1 SVEP1 LIN7A TLL1 HYDIN UNC80	2.76e-06	160	109	6	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_artery-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	WSCD1 GPER1 RAPGEF5 PROCR PIK3C2B JAG1	2.96e-06	162	109	6	25bb1b9709f960fdf90faff56e874f52a8f5d17e
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIMD1 GPER1 WTIP JAG1 GPC4 HYDIN	4.32e-06	173	109	6	2415b6ff49f334da570577d4e93484d024a3dbd5
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIMD1 GPER1 WTIP JAG1 GPC4 HYDIN	4.32e-06	173	109	6	2acd0693a2dfe04e3c1b2125ea63efe92d13150b
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_artery\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	WSCD1 GPER1 RAPGEF5 PROCR PIK3C2B JAG1	4.93e-06	177	109	6	5ff8dcfb030312126695d53a026d2e104a401b83
ToppCell	RA-07._Pericyte\|RA / Chamber and Cluster_Paper	HIP1 RAPGEF5 PROCR DSCAML1 LIN7A JAG1	5.60e-06	181	109	6	8dfb42d096db6c2df9b41303a7199d134d4bff07
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRCAM GRIK3 DSCAML1 UNC13C HYDIN UNC80	6.16e-06	184	109	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRCAM GRIK3 DSCAML1 UNC13C HYDIN UNC80	6.16e-06	184	109	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRCAM GRIK3 DSCAML1 UNC13C HYDIN UNC80	6.16e-06	184	109	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	RV-07._Pericyte\|RV / Chamber and Cluster_Paper	HIP1 RAPGEF5 PROCR DSCAML1 LIN7A JAG1	6.55e-06	186	109	6	c533b264fbe12bc35467486fc7fbde24ba968fe1
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Tac2_Myh4\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	WSCD1 GRIK3 PLPPR1 SATB1 UNC13C	6.65e-06	107	109	5	fc07dd90f280191bd643398eac5c8273651d0925
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RAPGEF5 CAMK2A LIN7A ITPR1 NGEF UNC13C	6.75e-06	187	109	6	f18628ffc7ff7c762b8339ba8822cf0c3157f469
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-OPC\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	WSCD1 HIP1 LIMD1 ASIC1 PLPPR1 TLL1	6.75e-06	187	109	6	daff7ccd3f1924cf2b34d3aca3eccde245aaf371
ToppCell	RV-07._Pericyte\|World / Chamber and Cluster_Paper	HIP1 RAPGEF5 PROCR DSCAML1 LIN7A JAG1	6.75e-06	187	109	6	dc274d6bbda619a2c914d84e2b4069cfef1739d1
ToppCell	normal_Lung-Myeloid_cells-pDCs\|normal_Lung / Location, Cell class and cell subclass	ENTPD7 XPO4 CDK14 DSCAML1 PARP6 NUP37	6.75e-06	187	109	6	d36751372fd40a46441f07735c9c3c5dcb503f24
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	WSCD1 HIP1 LIMD1 ASIC1 PLPPR1 TLL1	6.75e-06	187	109	6	5b7a1edee602e55d3400dc17dbb6b8aaa26defc0
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-GRIA2+_arterial_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	ADAMTSL1 GPER1 RAPGEF5 PROCR PIK3C2B JAG1	6.96e-06	188	109	6	366a2d59b9c81d8a7659749f9c07efa46b49a39a
ToppCell	COVID-19-Heart-EC_(POSTN)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ADAMTSL1 RAPGEF5 ITPR2 TLL1 TMEM150C UNC13C	7.18e-06	189	109	6	7346c1112e2e155dbd71b6dbc80e680fd262a691
ToppCell	3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	VWA5B2 ADAMTSL1 NRCAM CRYBA2 NRSN1 UNC80	7.40e-06	190	109	6	40d8b3403f4e38436b961cd3a2e69826cbae3042
ToppCell	3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine-Neuroendocrine_L.0.7.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	VWA5B2 ADAMTSL1 NRCAM CRYBA2 NRSN1 UNC80	7.40e-06	190	109	6	f6cbf6d292f488ada5f7581e1dceba6198b933d1
ToppCell	3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	VWA5B2 ADAMTSL1 NRCAM CRYBA2 NRSN1 UNC80	7.40e-06	190	109	6	a9a705455019e28d655636de73b07540798f82e6
ToppCell	facs-Pancreas-Endocrine-3m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWA5B2 USP9X ITPR1 CRYBA2 GPC4 UNC80	7.62e-06	191	109	6	b3de0393d6510543533cd851e47a0f95739a0e4e
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWA5B2 USP9X ITPR1 CRYBA2 GPC4 UNC80	7.62e-06	191	109	6	657297cd19d05a7e7bb74fc3a086fbd95f47aae4
ToppCell	IPF-Stromal-Fibroblast\|Stromal / Disease state, Lineage and Cell class	ADAMTSL1 PROCR KDM6B ABCA8 SVEP1 CSF1	8.33e-06	194	109	6	da3e1d39575969a069ef43e552afe94b2f441d0b
ToppCell	proximal-3-Endothelial-Vein\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	WSCD1 GPER1 RAPGEF5 ITPR1 PIK3C2B JAG1	8.58e-06	195	109	6	c81eb541c15b866f9b6ca6a5f1751c5f1243f4fb
ToppCell	proximal-Endothelial-Vein-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	WSCD1 GPER1 RAPGEF5 ITPR1 PIK3C2B JAG1	8.58e-06	195	109	6	df00f94facc5d6107aac83cef3c64fefc7f8e562
ToppCell	proximal-Endothelial-Vein\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	WSCD1 GPER1 RAPGEF5 ITPR1 PIK3C2B JAG1	8.58e-06	195	109	6	0aebdd635a956dd2367883c1cf73d73ce9790635
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NRCAM CDK14 FRY UBE3A PKD1 UNC80	8.83e-06	196	109	6	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	VWA5B2 WSCD1 NRCAM LHX9 TAF1L UNC80	8.83e-06	196	109	6	95544097577f20ed7f4144bd940471cde0617554
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	WSCD1 HIP1 NRCAM ASIC1 CMYA5 PLPPR1	8.83e-06	196	109	6	f374cb3ec31c6eef2cef9e07547bfd1e380553af
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	WSCD1 HIP1 NRCAM ASIC1 CMYA5 PLPPR1	8.83e-06	196	109	6	671c380b58d7f634b4fbec38c357d357ea4f3535
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NRCAM CDK14 ITPR1 FRY UBE3A UNC80	9.36e-06	198	109	6	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NRCAM CDK14 ITPR1 FRY UBE3A UNC80	9.36e-06	198	109	6	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	Bronchus_Control_(B.)-Endothelial-TX\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	WSCD1 GRIK3 PLPPR1 CRYBA2 TLL2 UNC80	9.36e-06	198	109	6	feac39036b5c0ab97b524cc366286942d136d42f
ToppCell	Bronchus_Control_(B.)-Endothelial-TX-Bronchial_vessel\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	WSCD1 GRIK3 PLPPR1 CRYBA2 TLL2 UNC80	9.36e-06	198	109	6	dcf334d13e5b0018fee24febccfef91c9e17843b
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NRCAM ASIC1 CMYA5 PLPPR1 HYDIN UNC80	9.63e-06	199	109	6	19a97e27a4758e794ce7246d295e112b47931a48
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Crhr2_Efemp1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	WSCD1 GRIK3 PLPPR1 SATB1 UNC13C	2.13e-05	136	109	5	e3a2425ba5ef538dbacab1479e682837ae42a888
ToppCell	Severe-B_naive-5\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	SPPL2B SQOR LIN7A TLL2 DCBLD2	4.23e-05	157	109	5	a57ee4a6febdff3ee3d1645836695e6e7c055cf8
ToppCell	RV-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	HIP1 RAPGEF5 FRY WTIP JAG1	4.63e-05	160	109	5	29c9b4770d0e73d59cffc7937b179484c76b6dcc
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	WSCD1 GRIK3 PLPPR1 SATB1 UNC13C	4.77e-05	161	109	5	dccb61d5e17a8f1c6d1fc146ee389f567659a0f0
ToppCell	5'-Adult-SmallIntestine-Epithelial-neuro-epithelial-EECs\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWA5B2 DSCAML1 LIN7A CRYBA2 NINL	4.91e-05	162	109	5	478cf560ef33c5c324142c76417447d4a571a2c9
ToppCell	facs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PROCR BMP1 GPC4 EIF2AK4 HYDIN	4.91e-05	162	109	5	56f1789e69a6cb29956e46aba92b290847327c1f
ToppCell	P15-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ERCC2 ADAMTSL1 DOCK5 PIK3C2B WNT3A	5.68e-05	167	109	5	5c3d0763f73628c71c71f9883556bb4f1639f3cc
ToppCell	Adult-Epithelial-lung_goblet_cell-D122\|Adult / Lineage, Cell type, age group and donor	ADAMTSL1 GRIK3 TMEM184A TLL1 TMEM150C	5.68e-05	167	109	5	6efbb2ef6adc8da5dd67210969f825f5cc8ed022
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	VWA5B2 GRIK3 PLPPR1 DSCAML1 UNC80	5.68e-05	167	109	5	c87ebfa8c3284ad33579190e148c95bcaf670d17
ToppCell	5'-Adult-SmallIntestine-Epithelial-Tuft-related-Tuft\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NRCAM LIMD1 CMYA5 ITPR2 FRY	5.84e-05	168	109	5	8072d0496b7b730c4601009eaa69ec5366d26d73
ToppCell	facs-Trachea-nan-24m-Mesenchymal-smooth_muscle_cell_of_trachea\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAPGEF5 DSCAML1 CDKL1 CRYBA2 TMEM184A	5.84e-05	168	109	5	6c7b490b6c844d0ea4c07edfc24c02284f9533c4
ToppCell	facs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l44-58\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RAPGEF5 CDKL1 WDPCP CRYBA2 TMEM184A	6.01e-05	169	109	5	d382a76d85875663502cc7dde2e3e0682605768e
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LVRN ADAMTSL1 OVCH1 ABCA8 SVEP1	6.53e-05	172	109	5	e37c0b5b547a7345179ab258dd2141fec7064c17
ToppCell	368C-Endothelial_cells-Endothelial-B_(Artery)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	GPER1 RAPGEF5 ITPR1 FRY PIK3C2B	6.71e-05	173	109	5	ec88e871b49331fca59bc610a8ae58e2d5e76bc1
ToppCell	368C-Endothelial_cells-Endothelial-B_(Artery)\|368C / Donor, Lineage, Cell class and subclass (all cells)	GPER1 RAPGEF5 ITPR1 FRY PIK3C2B	6.71e-05	173	109	5	22200fe74e33e2beae0eed289ca8476bbc0b1b2d
ToppCell	Bronchial_Biopsy-Epithelial-Ionocytes\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	WSCD1 NRCAM TRPM2 ITPR2 UNC80	7.08e-05	175	109	5	13b8f7dc38c90b74d4a20a84a8705d8e2ec244f6
ToppCell	5'-Adult-LymphNode-Hematopoietic-Plasma_cells\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TSHR CDK14 IFNAR2 EIF2AK4 EDEM1	7.08e-05	175	109	5	6a093c74a6f3daeff07759d6eec542fc5c709149
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 CSF1 GPC4 FGF3 UNC80	7.47e-05	177	109	5	c1f838e425ebb04482829b1957e3c1347127e6de
ToppCell	facs-Trachea-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l44-58\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RAPGEF5 CDKL1 CRYBA2 TMEM184A UNC80	7.68e-05	178	109	5	3d120458a0a56097532ebfa5fc6f77b52af2af2a
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIK3 LIN7A TLL1 NGEF UNC13C	7.88e-05	179	109	5	b35a7f8115c997c390201da01d7cb10b10769aec
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NRCAM LIN7A ITPR1 FRY UNC13C	7.88e-05	179	109	5	d3438fed0d85d5ed5afa8ff820c45143d77b6c0d
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GPER1 RAPGEF5 PROCR FRY PIK3C2B	7.88e-05	179	109	5	d2db9e70b780643f1e004c41a70464d0abe26088
ToppCell	facs-Marrow-B-cells-3m-Myeloid-monocyte_+_promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WSCD1 NRCAM CDK14 PLPPR1 DSCAML1	8.09e-05	180	109	5	c54af6fb11484dacd3efa1f10a487376ff820a5e
ToppCell	facs-Marrow-B-cells-3m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WSCD1 NRCAM CDK14 PLPPR1 DSCAML1	8.09e-05	180	109	5	07ac979b21be2425294d9818c48b5a1e6f014c19
ToppCell	droplet-Marrow-nan-18m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 CSF1 GPC4 TMEM150C FGF3	8.30e-05	181	109	5	382337427be3c11ecd03e9fa2c2e831a9674c6a7
ToppCell	RA-07._Pericyte\|World / Chamber and Cluster_Paper	HIP1 RAPGEF5 PROCR DSCAML1 LIN7A	8.52e-05	182	109	5	2075efeae633550fb2eb026d0dfd741c8252482e
ToppCell	Epithelial-lung_neuroendocrine_cell_(PNEC)\|World / Lineage, Cell type, age group and donor	VWA5B2 NRCAM DSCAML1 NRSN1 UNC80	8.52e-05	182	109	5	57bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	HIP1 NRCAM PLPPR1 CDKL1 ITPR2	8.52e-05	182	109	5	041bc819e6cf2618bf86bce8dfe2df673f392ba3
ToppCell	LA-07._Pericyte\|World / Chamber and Cluster_Paper	HIP1 RAPGEF5 DSCAML1 LIN7A JAG1	8.75e-05	183	109	5	e3835db4795362b0442d5893baf2a78efcc20428
ToppCell	LV-07._Pericyte\|World / Chamber and Cluster_Paper	HIP1 RAPGEF5 DSCAML1 LIN7A JAG1	8.75e-05	183	109	5	273db6a3b00a93ca852498471187b642b5368185
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DSCAML1 FRY JAG1 GPC4 HYDIN	8.75e-05	183	109	5	cfae90c309622b5d499e62a3a8a8b9746478d28d
ToppCell	droplet-Lung-immune-endo-depleted-3m-Epithelial-lung_neuroendocrine_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPER1 PLPPR1 CRYBA2 TMEM184A UNC80	9.20e-05	185	109	5	30263c558ee331e0879abcf8b4c2427ff05f9fe7
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HIP1 NRCAM PLPPR1 NINL UNC13C	9.20e-05	185	109	5	03f64a7132b13a01ba47187e0e15c13ac88f7cb2
ToppCell	droplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l20-1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CAMK2A PROCR BMP1 CSF1 DCBLD2	9.20e-05	185	109	5	d5f5866924648a3c14e2596218fd548a31777aa3
ToppCell	droplet-Lung-immune-endo-depleted-3m-Epithelial-Neuroendocrine\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPER1 PLPPR1 CRYBA2 TMEM184A UNC80	9.20e-05	185	109	5	1b000ca11970db8f347eb97ff44605d562aea70a
ToppCell	LV-07._Pericyte\|LV / Chamber and Cluster_Paper	HIP1 RAPGEF5 DSCAML1 LIN7A JAG1	9.20e-05	185	109	5	acb38eba871ec72f2a8136a33b87d33b8c85465d
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RAPGEF5 CAMK2A LIN7A NGEF UNC13C	9.44e-05	186	109	5	bdbe290f81106a53c8c30a92fbb385597c62b2ac
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	HIP1 PLPPR1 ITPR1 ITPR2 NINL	9.68e-05	187	109	5	b93cf4dfe8ffb89348ee7bccc9f284189f7240a2
ToppCell	droplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l20-25\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LVRN PROCR BMP1 CSF1 DCBLD2	9.68e-05	187	109	5	0d4b7da81036c2aa678654b9fe49c939d08fcd9b
ToppCell	normal_Lung-Myeloid_cells-pDCs\|Myeloid_cells / Location, Cell class and cell subclass	ENTPD7 XPO4 CDK14 DSCAML1 PARP6	9.68e-05	187	109	5	a3592f056e1c2f82ba325fea2ecc4dd6c6347c81
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CAMK2A CMYA5 DOCK5 FRY TMEM150C	9.68e-05	187	109	5	24c2a3962da364e46e98abeab5f8234376fa26bb
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B0\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	THAP5 FANCM TRIM27 ITPR2 PKD1	9.68e-05	187	109	5	816d37a70f7ec382a268fe828b3dfe737a36a4bf
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWA5B2 USP9X ITPR1 CRYBA2 GPC4	9.93e-05	188	109	5	e99e3765b48392c987cf0c5ccbded0655637d7b7
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RAPGEF5 CAMK2A LIN7A ITPR1 NGEF	9.93e-05	188	109	5	50c1b1d690f0e9443082f2adf4f1b8e9ce4cd337
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ADAMTSL1 NRCAM RAPGEF5 FRY TLL1	1.02e-04	189	109	5	7659c7bbd58ee959a159294fb8d17317bbcc5681
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RAPGEF5 CAMK2A LIN7A ITPR1 NGEF	1.02e-04	189	109	5	a75226616340045b581d08429d2e123e041dee55
ToppCell	RA-10._Endothelium_II\|RA / Chamber and Cluster_Paper	ADAMTSL1 RAPGEF5 ITPR1 ITPR2 TLL1	1.02e-04	189	109	5	c81787a8c662db5d7814c583dd64562857629e81
ToppCell	renal_medulla_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	HIP1 NRCAM STAG1 CDKL1 FRY	1.02e-04	189	109	5	830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-bronchial_smooth_muscle_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CMYA5 NGEF TMEM150C PDP2 DAGLA	1.02e-04	189	109	5	4dc32b463546bbe7250dddd281b92ad17ec22da1
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-Airway_Smooth_Muscle\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CMYA5 NGEF TMEM150C PDP2 DAGLA	1.02e-04	189	109	5	0d06bf0d7191d13a1c4f30a7881e7ea1093bfd6f
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RAPGEF5 CAMK2A LIN7A ITPR1 NGEF	1.02e-04	189	109	5	c3df0e3c50af8f1cfb4d790e668bd7f42b276992
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RAPGEF5 CAMK2A LIN7A ITPR1 NGEF	1.04e-04	190	109	5	d594da827e3c16644952b9589cc12b947ce36279
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	WSCD1 HIP1 NRCAM ASIC1 DSCAML1	1.04e-04	190	109	5	6c7e1086c0a274cd5527c3104106e372811c9905
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RAPGEF5 CAMK2A LIN7A ITPR1 NGEF	1.04e-04	190	109	5	49e09cdb843b3d889a06a811aa5affae68b25a75
ToppCell	PCW_07-8.5-Endothelial-Endothelial_mature-endo_venous_(13)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	WSCD1 RAPGEF5 PROCR TLL1 SPINK5	1.07e-04	191	109	5	54029b68fb78163c969890886ab0f8fb0dcf3c20
ToppCell	COVID-19-Heart-EC_(POSTN)\|Heart / Disease (COVID-19 only), tissue and cell type	ADAMTSL1 RAPGEF5 ITPR2 TLL1 UNC13C	1.10e-04	192	109	5	c0c34785a7bdf461722029b322e9184e3d9b3c26
ToppCell	368C-Endothelial_cells-Endothelial-B_(Artery)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	GPER1 PROCR ITPR1 CSF1 PIK3C2B	1.10e-04	192	109	5	aedddccacf60e884af044cefba6c64ca10ac97d2
Drug	Fenoterol hydrobromide [1944-12-3]; Up 200; 10.4uM; MCF7; HT_HG-U133A	COMT ASIC1 CDK14 SVEP1 ITPR2 BMP1 FRY USP7 DCBLD2	5.20e-07	200	109	9	5432_UP
Drug	Atropine-N-oxide hydrochloride [4574-60-1]; Up 200; 11.8uM; MCF7; HT_HG-U133A	ASIC1 RAPGEF5 KDM6B LIN7A ITPR1 GEMIN8 DAGLA DCBLD2	5.09e-06	198	109	8	6812_UP
Drug	Carbetapentane citrate [23142-01-0]; Down 200; 7.6uM; MCF7; HT_HG-U133A	ENTPD7 PCYT1A GPER1 SPPL2B LIN7A GEMIN8 JAG1 SPINK5	5.09e-06	198	109	8	2623_DN
Disease	Hypoxic Brain Damage	ITPR1 ITPR2	1.35e-05	2	109	2	C1140716
Disease	Anoxic Encephalopathy	ITPR1 ITPR2	1.35e-05	2	109	2	C0003132
Disease	Brain Hypoxia	ITPR1 ITPR2	1.35e-05	2	109	2	C1527348
Disease	Anoxia of brain	ITPR1 ITPR2	1.35e-05	2	109	2	C0995195
Disease	corpus collosum mid-posterior volume measurement	SQOR JAG1 UNC13C	1.06e-04	25	109	3	EFO_0010300
Disease	symmetrical dimethylarginine measurement	AKR1B10 AKR1B15	4.79e-04	9	109	2	EFO_0006523
Disease	Malignant mesothelioma	SETDB1 SETD2 CSF1 CCNE2	7.28e-04	109	109	4	C0345967
Disease	Glioblastoma Multiforme	JAG1 TAF1L STAG2 DYRK2	7.79e-04	111	109	4	C1621958
Disease	autosomal dominant cerebellar ataxia (implicated_via_orthology)	ITPR1 ITPR2	8.71e-04	12	109	2	DOID:1441 (implicated_via_orthology)
Disease	Down syndrome (implicated_via_orthology)	DSCAML1 DYRK2	1.38e-03	15	109	2	DOID:14250 (implicated_via_orthology)
Disease	Neoplasm of uncertain or unknown behavior of bladder	ERCC2 STAG2	1.38e-03	15	109	2	C0496930
Disease	Benign neoplasm of bladder	ERCC2 STAG2	1.38e-03	15	109	2	C0154017
Disease	Carcinoma in situ of bladder	ERCC2 STAG2	1.38e-03	15	109	2	C0154091
Disease	Intellectual Disability	STAG1 CAMK2A KDM6B SETD2 FRY TAF1 STAG2	1.38e-03	447	109	7	C3714756
Disease	cytokine measurement	LVRN RAPGEF5 ITPR1 IFNAR2 NGEF USP7 UNC13C	1.65e-03	461	109	7	EFO_0004873
Disease	Bladder Neoplasm	ERCC2 USP7 NRSN1 STAG2	1.84e-03	140	109	4	C0005695
Disease	Malignant neoplasm of urinary bladder	ERCC2 USP7 NRSN1 STAG2	1.89e-03	141	109	4	C0005684
Disease	Carcinoma of bladder	ERCC2 STAG2	1.99e-03	18	109	2	C0699885
Disease	Prostatic Neoplasms	ERCC2 COMT ITPR1 SETDB1 SETD2 USP7 TAF1L SPINK5	2.07e-03	616	109	8	C0033578
Disease	Malignant neoplasm of prostate	ERCC2 COMT ITPR1 SETDB1 SETD2 USP7 TAF1L SPINK5	2.07e-03	616	109	8	C0376358
Disease	Malignant neoplasm of breast	COMT NRCAM GPER1 GRIK3 BMP1 SETD2 NLRP14 CSF1 TLL1 JAG1 FGF3	2.10e-03	1074	109	11	C0006142
Disease	Major Depressive Disorder	COMT RAPGEF5 CAMK2A CMYA5 EDEM1	2.12e-03	243	109	5	C1269683
Disease	hydrocephalus (implicated_via_orthology)	ADD1 HYDIN	2.22e-03	19	109	2	DOID:10908 (implicated_via_orthology)
Disease	COVID-19, osteoarthritis	LIMD1 IFNAR2	2.46e-03	20	109	2	MONDO_0005178, MONDO_0100096
Disease	autism spectrum disorder (implicated_via_orthology)	NRCAM CAMK2A DSCAML1 UBE3A	2.48e-03	152	109	4	DOID:0060041 (implicated_via_orthology)
Disease	Unipolar Depression	COMT RAPGEF5 CAMK2A CMYA5 EDEM1	2.79e-03	259	109	5	C0041696
Disease	R-warfarin measurement	ADAMTSL1 STAG1 PLPPR1 PRTFDC1 DOCK5	3.08e-03	265	109	5	EFO_0803324
Disease	bone density	ADAMTSL1 LIN7C LHX9 CSF1 UBE3A JAG1	3.23e-03	388	109	6	EFO_0003923
Disease	Mammary Carcinoma, Human	COMT NRCAM GPER1 SETD2 CSF1 JAG1 FGF3	3.40e-03	525	109	7	C4704874
Disease	Mammary Neoplasms, Human	COMT NRCAM GPER1 SETD2 CSF1 JAG1 FGF3	3.40e-03	525	109	7	C1257931
Disease	Mammary Neoplasms	COMT NRCAM GPER1 SETD2 CSF1 JAG1 FGF3	3.47e-03	527	109	7	C1458155
Disease	Anhedonia	COMT SETDB1	3.54e-03	24	109	2	C0178417
Disease	congenital heart disease (is_implicated_in)	TLL1 JAG1	3.54e-03	24	109	2	DOID:1682 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
EQCRDEYLADLYHFV	BARGIN	211	Q6ZT62
YELREFLEDTCVQYV	PROCR	176	Q9UNN8
QEELQEYCRHHEITY	EIF2AK4	1436	Q9P2K8
EYCRHHEITYVALVS	EIF2AK4	1441	Q9P2K8
YCNFYVMHREVESLE	CCAR1	416	Q8IX12
EIEFSVQDRYYLCVS	EXOC1L	26	A0A1B0GW35
EVCEVYTLHRETFYL	CCNE2	151	O96020
LAYICQTYERFSHVA	CNOT9	196	Q92600
YQYVLERDRHSGEFC	CRYBA2	161	P53672
DFFEDDTISEYIYHC	ABHD4	231	Q8TB40
RHIDCAYVYQNEHEV	AKR1B10	41	O60218
LTLVFEYVHTDLCQY	CDK14	206	O94921
AYRHLVGVCYTEDEA	CYC1	131	P08574
YLVAFVICDYDHVNR	LVRN	306	Q6Q4G3
EIERHDSCAYDYLEV	BMP1	481	P13497
DYNEYFRDLNHICVI	PRTFDC1	201	Q9NRG1
IAYVNFVNHCYVDTE	ITPR2	1421	Q14571
QAIEEVYYDHLRCAF	PHLDB3	581	Q6NSJ2
FCTAIREVYQYMHET	LIN7A	61	O14910
FCNAVREVYEHVYET	LIN7C	46	Q9NUP9
TVDSENKIYCVRDYH	LIMD1	576	Q9UGP4
CDVQHTEHVYRVYVT	ENTPD7	296	Q9NQZ7
DTREDYICYARFNHT	NRCAM	211	Q92823
ERLDSYVNADHDLYC	GEMIN8	166	Q9NWZ8
AYINFLNHCYVDTEV	ITPR1	1431	Q14643
VNSQYHFTDEYLECV	GPC4	176	O75487
HFTDEYLECVSKYTE	GPC4	181	O75487
EAVQELCSEYRHYVR	SPINK5	561	Q9NQ38
TVCPDYQSYFHTIEE	KRT38	146	O76015
YASEHYSAECEFVER	FGF3	106	P11487
ELYIVRTDDQFYNCH	FANCM	966	Q8IYD8
LYESEHDSEEATRCY	KDM6B	116	O15054
DLRSNRVVADQYCHY	ADAMTSL1	326	Q8N6G6
LQIASDSHQYDRIYC	PCMTD1	151	Q96MG8
ERYDAVQHCRYVDEV	PCYT1A	131	P49585
VYCRAHFETLLQGEY	LHX9	181	Q9NQ69
VRSYLHQFYEDCTAS	NRSN1	26	Q8IZ57
IEDDSRCLYTHEEYI	DCAF5	376	Q96JK2
YQHDTSLPHCRFYEE	ERCC2	146	P18074
YGERESSYVFLHVCI	NLRP4	441	Q96MN2
SRNAAYTVDCEDYVH	NUP37	6	Q8NFH4
YTVDCEDYVHVVEFN	NUP37	11	Q8NFH4
YCVSVYLEHSDEQAV	IFNAR2	206	P48551
YQTLCYTHDDLRNVD	PIK3C2B	406	O00750
YIIHYFDDILCAAET	ERVK-18	191	Q9QC07
HACAQAVSERLFYYV	PDP2	146	Q9P2J9
CTHYQSFLEYREVVD	COMT	241	P21964
IIFQYIHCDEIYEAI	WDPCP	491	O95876
LDVVVSLAERHYYNC	CDC16	231	Q13042
TEYYCRTDCTDFHAE	HYDIN	4956	Q4G0P3
HRDCENYTEAAYTLL	DOCK5	1251	Q9H7D0
DYEEHDKACVRTFYE	CSF1	126	P09603
FEYCDHTVLHELDRY	CDKL1	81	Q00532
TTYLAQQYCHEAIRE	PDSS1	376	Q5T2R2
HVLEEDIGYYLCQAS	DSCAML1	756	Q8TD84
DDAYLCIHEDQTVYI	FRRS1	256	Q6ZNA5
EATETYTLEYCRQHS	CMYA5	3831	Q8N3K9
DVEDAICLHAFYYAI	EDEM1	451	Q92611
VDIVYTSCHDAVYET	DAGLA	366	Q9Y4D2
ESYRSCYVVENHLAI	KCNE1	101	P15382
EDSDSCHFNYLRIYN	DCBLD2	121	Q96PD2
NVVCRYLHEAYADIT	FRY	2206	Q5TBA9
LYDAVHIVSVCYQRA	GRIK3	326	Q13003
SINVYDYNCHVDLIR	SART3	106	Q15020
VIDFGSSCYEHQRVY	DYRK2	366	Q92630
RVLESYRSCYVVENH	KCNE1B	101	A0A087WTH5
YRSCYVVENHLAIEQ	KCNE1B	106	A0A087WTH5
AHVDLRDCVTYQTEY	PKD1	2171	P98161
VSDHVCTRFFFVYED	PARP6	586	Q2NL67
VAHFEYQIRVTCDDY	JAG1	176	P78504
VLREYINECDSDYHE	USP9X	856	Q93008
NCIHTDDDEKISYRY	SQOR	126	Q9Y6N5
EVSFYNVTERCHTFT	TRIM27	446	P14373
SFEIERHDNCAYDYL	TLL1	506	O43897
DSVRDCYEAFVIYSF	TMEM184A	121	Q6ZMB5
VNICYQTITEYDEHL	TAF1L	1616	Q8IZX4
IVNVCYQTLTEYDEH	TAF1	1596	P21675
VHVLEREVCEHTYYS	OVCH1	721	Q7RTY7
VFNLHERYYDIAVLC	GPER1	116	Q99527
IQVILDCSHLYDYTV	HIP1	226	O00291
SDVCDIVYRYAADHF	NGEF	346	Q8N5V2
EEIFCHVYITEHSYV	RAPGEF5	241	Q92565
FAVEFRHYRYEIVCS	TMEM150C	211	B9EJG8
IVAREYYSEADASHC	CAMK2A	101	Q9UQM7
NHYVSQLREVYSSCD	NINL	6	Q9Y2I6
LAYYFECTDTFQVHI	PLPPR1	31	Q8TBJ4
TYYNLEHFTCESCRI	SVEP1	1006	Q4LDE5
VFCVVEHYENAIEYD	SATB1	76	Q01826
DISCRDFIEEYVTAY	SETDB1	326	Q15047
AHCYETNEDVYCEVS	ABCA8	156	O94911
RHIDCAYFYENQHEV	AKR1B15	41	C9JRZ8
VEEAFYYIHNLVVAC	ADD1	311	P35611
VLLCVCTERVQYYFH	ASIC1	56	P78348
EQDYLCHVYVRNDSL	YKT6	61	O15498
LNCDYSIYIHNVTRE	SIRPB2	106	Q5JXA9
VVEEEENSCTYYECH	ZMYND19	156	Q96E35
EAFYTLVCLHQAEYS	XPO4	1076	Q9C0E2
NVECDLTYHNVYSRD	UBE3A	266	Q05086
CINYSYLEDTEHIDG	UNC80	626	Q8N2C7
YIFDNCHELYSQLTD	UNC13C	1556	Q8NB66
TAEDCENVYHLVYSA	STAG2	406	Q8N3U4
EYEHRAIGVFTECYR	TRPM2	681	O94759
VDYGTEVLQIEHSYC	THAP5	311	Q7Z6K1
EETVLYIEHRYVCSE	ZNF574	6	Q6ZN55
YCHRFDIQVQSSRVY	SPPL2B	431	Q8TCT7
YRTHRTFVQHYECDD	ZNF840P	141	A6NDX5
IERHDSCAYDYLEVR	TLL2	511	Q9Y6L7
EDCENVYHLVYSAHR	STAG1	411	Q8WVM7
CYFDLIEENVYLTER	SETD2	1471	Q9BYW2
FQSSYIREQYVLTHC	VWA5B2	656	Q8N398
YVSCQECTRVYDVHT	WNT3A	336	P56704
DVENNIYCVRDYHTV	WTIP	331	A6NIX2
VSHCQDACAERSYVY	WSCD1	171	Q658N2
YFRDLYHRVDVIFCD	USP7	786	Q93009
ERHECYDVENFYLRE	ZNF836	76	Q6ZNA1
ETLQAFDSHYDYTIC	TSHR	376	P16473
YLCTEKSNVYRDHSE	LEG1	306	Q6P5S2
EYENCYVFTHLHVQE	NLRP14	471	Q86W24