Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioninsulin-like growth factor binding

ITGB4 IGFBPL1

1.16e-0419172GO:0005520
GeneOntologyCellularComponentcell surface

TGFB1 ADGRA2 ITGB4 SRPX STRCP1 PCSK9 STRC

1.43e-051111177GO:0009986
GeneOntologyCellularComponent9+2 non-motile cilium

STRCP1 STRC

5.63e-0514172GO:0097732
GeneOntologyCellularComponentkinocilium

STRCP1 STRC

5.63e-0514172GO:0060091
GeneOntologyCellularComponentactin-based cell projection

TGFB1 ADGRA2 STRCP1 STRC

6.36e-05278174GO:0098858
GeneOntologyCellularComponentstereocilium tip

STRCP1 STRC

1.42e-0422172GO:0032426
GeneOntologyCellularComponentcollagen-containing extracellular matrix

TGFB1 ITGB4 IGFBPL1 SRPX

7.48e-04530174GO:0062023
GeneOntologyCellularComponentstereocilium

STRCP1 STRC

1.41e-0369172GO:0032420
GeneOntologyCellularComponentextracellular matrix

TGFB1 ITGB4 IGFBPL1 SRPX

1.65e-03656174GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

TGFB1 ITGB4 IGFBPL1 SRPX

1.67e-03658174GO:0030312
GeneOntologyCellularComponentstereocilium bundle

STRCP1 STRC

1.85e-0379172GO:0032421
GeneOntologyCellularComponentnon-motile cilium

STRCP1 STRC

1.08e-02196172GO:0097730
GeneOntologyCellularComponentreceptor complex

GABBR2 ITGB4 NPR1

1.09e-02581173GO:0043235
MousePhenodecreased circulating renin level

TGFB1 NPR1

4.81e-0510152MP:0003353
MousePhenoabnormal cochlear microphonics

STRCP1 STRC

1.63e-0418152MP:0004412
MousePhenoabnormal cochlear potential

STRCP1 STRC

1.82e-0419152MP:0006332
MousePhenomyocardium necrosis

TGFB1 NPR1

2.23e-0421152MP:0006085
MousePhenocardiac muscle necrosis

TGFB1 NPR1

2.93e-0424152MP:0010632
MousePhenoincreased circulating mineralocorticoid level

TGFB1 NPR1

3.44e-0426152MP:0003373
MousePhenoincreased circulating aldosterone level

TGFB1 NPR1

3.44e-0426152MP:0002666
MousePhenoabnormal cochlear outer hair cell physiology

STRCP1 STRC

4.00e-0428152MP:0004434
MousePhenoabnormal circulating renin level

TGFB1 NPR1

4.29e-0429152MP:0003349
MousePhenoabnormal circulating aldosterone level

TGFB1 NPR1

7.39e-0438152MP:0005346
MousePhenoabnormal circulating mineralocorticoid level

TGFB1 NPR1

7.39e-0438152MP:0003372
MousePhenoabnormal cochlear hair cell physiology

STRCP1 STRC

8.19e-0440152MP:0004432
MousePhenoabnormal aldosterone level

TGFB1 NPR1

8.60e-0441152MP:0011415
MousePhenoabsent distortion product otoacoustic emissions

STRCP1 STRC

8.60e-0441152MP:0004737
DomainEGF_extracell

ATRN ITGB4 ADAM33

1.71e-0560163IPR013111
DomainEGF_2

ATRN ITGB4 ADAM33

1.71e-0560163PF07974
DomainANF_receptor

GABBR2 NPR1

4.50e-0437162PF01094
DomainANF_lig-bd_rcpt

GABBR2 NPR1

4.50e-0437162IPR001828
DomainPeripla_BP_I

GABBR2 NPR1

5.01e-0439162IPR028082
DomainPSI

ATRN ITGB4

6.37e-0444162IPR016201
DomainPSI

ATRN ITGB4

6.97e-0446162SM00423
DomainEGF_1

ATRN ITGB4 ADAM33

1.23e-03255163PS00022
DomainEGF-like_CS

ATRN ITGB4 ADAM33

1.32e-03261163IPR013032
DomainEGF_2

ATRN ITGB4 ADAM33

1.38e-03265163PS01186
Domain-

IGDCC3 ADGRA2 ITGB4 IGFBPL1

2.04e-036631642.60.40.10
DomainIg-like_fold

IGDCC3 ADGRA2 ITGB4 IGFBPL1

2.56e-03706164IPR013783
DomainIG

IGDCC3 ADGRA2 IGFBPL1

5.12e-03421163SM00409
DomainIg_sub

IGDCC3 ADGRA2 IGFBPL1

5.12e-03421163IPR003599
DomainGrowth_fac_rcpt_

ATRN IGFBPL1

7.70e-03156162IPR009030
DomainIG_LIKE

IGDCC3 ADGRA2 IGFBPL1

7.84e-03491163PS50835
Domainfn3

IGDCC3 ITGB4

8.28e-03162162PF00041
DomainIg-like_dom

IGDCC3 ADGRA2 IGFBPL1

8.37e-03503163IPR007110
DomainFN3

IGDCC3 ITGB4

1.07e-02185162SM00060
DomainIg_I-set

IGDCC3 IGFBPL1

1.12e-02190162IPR013098
DomainI-set

IGDCC3 IGFBPL1

1.12e-02190162PF07679
DomainFN3

IGDCC3 ITGB4

1.23e-02199162PS50853
DomainFN3_dom

IGDCC3 ITGB4

1.35e-02209162IPR003961
DomainEGF_3

ATRN ADAM33

1.68e-02235162PS50026
DomainIGc2

IGDCC3 IGFBPL1

1.68e-02235162SM00408
DomainIg_sub2

IGDCC3 IGFBPL1

1.68e-02235162IPR003598
DomainEGF

ATRN ADAM33

1.68e-02235162SM00181
DomainEGF-like_dom

ATRN ADAM33

1.88e-02249162IPR000742
PathwayREACTOME_SYNDECAN_INTERACTIONS

TGFB1 ITGB4

5.01e-0514112MM14923
PathwayREACTOME_SYNDECAN_INTERACTIONS

TGFB1 ITGB4

1.92e-0427112M27217
PathwayREACTOME_NON_INTEGRIN_MEMBRANE_ECM_INTERACTIONS

TGFB1 ITGB4

2.71e-0432112MM14924
Pubmed

Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.

STRCP1 STRC

2.25e-07217211687802
Pubmed

Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.

STRCP1 STRC

2.25e-07217234910522
Pubmed

Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.

STRCP1 STRC

6.74e-07317230801007
Pubmed

Involvement of the NF-kappa B/matrix metalloproteinase pathway in cardiac fibrosis of mice lacking guanylyl cyclase/natriuretic peptide receptor A.

TGFB1 NPR1

6.74e-07317215710627
Pubmed

Transforming growth factor β1 antagonizes the transcription, expression and vascular signaling of guanylyl cyclase/natriuretic peptide receptor A - role of δEF1.

TGFB1 NPR1

6.74e-07317226934489
Pubmed

Lack of NPR1 Increases Vascular Endothelial Adhesion through Induction of Integrin Beta 4.

ITGB4 NPR1

6.74e-07317236293483
Pubmed

Serum proteins TGFBI, PCSK9, and CCL14 are potential biomarkers for different traditional Chinese medicine syndromes of multidrug-resistant tuberculosis.

TGFB1 PCSK9

6.74e-07317231909895
Pubmed

Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.

STRCP1 STRC

1.35e-06417218849963
Pubmed

Association of TGF-beta1, CD14, IL-4, IL-4R and ADAM33 gene polymorphisms with asthma severity in children and adolescents.

TGFB1 ADAM33

2.25e-06517218425216
Pubmed

An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells.

STRCP1 STRC

2.25e-06517224920589
Pubmed

Development of a screening set for new (CAG/CTG)n dynamic mutations.

NPR1 PTPRE

3.37e-0661728786123
Pubmed

The mouse mahogany locus encodes a transmembrane form of human attractin.

ATRN ADAM33

4.72e-06717210086356
Pubmed

Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane.

STRCP1 STRC

6.29e-06817221165971
Pubmed

Crucial role of fibroblasts in regulating epidermal morphogenesis.

TGFB1 ITGB4

8.08e-06917212397374
Pubmed

Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor.

TGFB1 ADGRA2

1.01e-051017221282641
Pubmed

Clarin-2 is essential for hearing by maintaining stereocilia integrity and function.

STRCP1 STRC

1.23e-051117231448880
Pubmed

Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.

STRCP1 STRC

1.23e-051117231776257
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

TGFB1 ATRN ITGB4 NPR1 SLC27A3 PCSK9

1.49e-05120117635696571
Pubmed

EMILIN1-α4/α9 integrin interaction inhibits dermal fibroblast and keratinocyte proliferation.

TGFB1 ITGB4

2.04e-051417221949412
Pubmed

Mammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1.

STRCP1 STRC

3.05e-051717220856818
Pubmed

Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning.

TGFB1 ITGB4

7.26e-052617225446530
Pubmed

Replication of genetic association studies in asthma and related phenotypes.

TGFB1 ADAM33

7.26e-052617220395963
Pubmed

The influence of genetic variation in 30 selected genes on the clinical characteristics of early onset breast cancer.

TGFB1 ITGB4

9.06e-052917219094228
Pubmed

Genetic polymorphisms in adaptive immunity genes and childhood acute lymphoblastic leukemia.

TGFB1 ADAM33

9.06e-052917220716621
Pubmed

Foxf2 Is Required for Brain Pericyte Differentiation and Development and Maintenance of the Blood-Brain Barrier.

TGFB1 ADGRA2

1.25e-043417226120030
Pubmed

Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.

GHDC ADGRA2 NPR1

1.47e-0421417322199357
Pubmed

Assessing the reproducibility of asthma candidate gene associations, using genome-wide data.

TGFB1 ADAM33

1.56e-043817219264973
Pubmed

A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis.

STRCP1 STRC

1.56e-043817238346162
Pubmed

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

TGFB1 ATRN ITGB4

2.51e-0425717316335952
Pubmed

A large-scale candidate gene association study of age at menarche and age at natural menopause.

GABBR2 TGFB1 PCSK9

3.06e-0427517320734064
Pubmed

GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier.

TGFB1 ADGRA2

3.79e-045917221421844
InteractionEDN3 interactions

TGFB1 ATRN PCSK9

7.97e-05108163int:EDN3
InteractionLYZL1 interactions

TGFB1 ATRN PCSK9

1.04e-04118163int:LYZL1
Cytoband15q15.3

STRCP1 STRC

3.85e-052517215q15.3
Cytoband20p13

ATRN ADAM33

6.50e-0410217220p13
CytobandEnsembl 112 genes in cytogenetic band chr20p13

ATRN ADAM33

9.43e-04123172chr20p13
CytobandEnsembl 112 genes in cytogenetic band chr15q15

STRCP1 STRC

1.34e-03147172chr15q15
CytobandEnsembl 112 genes in cytogenetic band chr1q21

NPR1 SLC27A3

9.63e-03404172chr1q21
GeneFamilyFibronectin type III domain containing

IGDCC3 ITGB4

7.58e-03160152555
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

IGDCC3 IGFBPL1

7.67e-03161152593
CoexpressionGSE17721_PAM3CSK4_VS_GADIQUIMOD_1H_BMDC_UP

IGDCC3 ADAM33 SLC27A3 PTPRE

7.24e-06200174M3962
CoexpressionLIM_MAMMARY_STEM_CELL_UP

ADGRA2 ITGB4 SRPX SLC27A3 PTPRE

1.03e-05479175M2573
CoexpressionLIM_MAMMARY_STEM_CELL_UP

ADGRA2 ITGB4 SRPX SLC27A3 PTPRE

1.07e-05483175MM1082
CoexpressionNIKOLSKY_BREAST_CANCER_20P13_AMPLICON

ATRN ADAM33

1.11e-058172M6821
CoexpressionNABA_MATRISOME_POORLY_METASTATIC_MELANOMA_TUMOR_CELL_DERIVED

TGFB1 SRPX

1.28e-0426172M47981
CoexpressionERBB2_UP.V1_UP

GABBR2 ITGB4 PTPRE

2.37e-04190173M2636
CoexpressionMEK_UP.V1_UP

GABBR2 ITGB4 PTPRE

2.55e-04195173M2725
CoexpressionGSE44955_MCSF_VS_MCSF_AND_IL27_STIM_MACROPHAGE_DN

IGDCC3 NPR1 SLC27A3

2.71e-04199173M9701
CoexpressionHUANG_FOXA2_TARGETS_DN

ITGB4 SRPX

2.75e-0438172M16701
CoexpressionNABA_MATRISOME_POORLY_METASTATIC_MELANOMA

TGFB1 SRPX

2.75e-0438172M47982
CoexpressionHALLMARK_P53_PATHWAY

TGFB1 ITGB4 PTPRE

2.75e-04200173M5939
CoexpressionHALLMARK_APICAL_SURFACE

SRPX PCSK9

3.69e-0444172M5916
ToppCellkidney_cells-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADGRA2 ITGB4 SLC27A3 PTPRE

5.29e-07177174227d4f423b00be2e0c5797e2c5275d342e69a0f4
ToppCellkidney_cells-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADGRA2 ITGB4 SLC27A3 PTPRE

5.29e-0717717466ffa279147961080c104242a08b176e301d80e3
ToppCellkidney_cells-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADGRA2 ITGB4 SLC27A3 PTPRE

5.29e-071771740cbf54608d2ba0a0500af142f2029fe5e118c3c2
ToppCellBronchial-10x5prime-Stromal-Fibroblastic-Fibro_immune_recruiting|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PCDHAC2 ADGRA2 ADAM33 SRPX

8.45e-071991740cdbedf09ec72734b86ddab3fec562e066afed92
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Neuroepithelial-Proteoglycan-expressing_cell|10w / Sample Type, Dataset, Time_group, and Cell type.

TGFB1 ITGB4 SRPX PCSK9

8.62e-0720017407d2133c85e0a4eb8bef653ee15ecd0f1b2bbd44
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Neuroepithelial|10w / Sample Type, Dataset, Time_group, and Cell type.

TGFB1 ITGB4 SRPX PCSK9

8.62e-07200174ff0b2675c68e9fc1fa16b3276431f199f3642eac
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Fam159b|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

IGDCC3 IGFBPL1 PTPRE

2.29e-051481739205b26e0d042b342cc643cda0f4f3f8bb392d00
ToppCelldroplet-Liver-LIVER_NPC-30m-Myeloid-myeloid_leukocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SRPX SLC27A3 PTPRE

2.79e-0515817390ca742739a208d457db087655ba3d1c18a9da57
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Epithelial-neuronal_stem_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SRPX SLC27A3 PTPRE

3.11e-051641730853e75b60b2a78257b660910c3ee15b09c5f5b0
ToppCell10x5'-lymph-node_spleen-Myeloid_Dendritic-pDC|lymph-node_spleen / Manually curated celltypes from each tissue

ADAM33 SRPX PTPRE

3.35e-05168173cfed36fece51871a5abbcde71f6bd5e7212357ff
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TGFB1 ITGB4 NPR1

3.47e-05170173af8b56555cbd5a1016ab9ec2ce88225c58c89648
ToppCellE15.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

TGFB1 IGDCC3 NPR1

3.53e-051711733112d15f2a28cf4a71992db4971d960716dc1264
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TGFB1 ITGB4 NPR1

3.59e-051721739a1743abcd5fbd38253ea84d88ad716cfb71de36
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage_3|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

ADAM33 NPR1 SRPX

3.84e-05176173bfa1633e1b7a8a2f04d37fa07284fe9bc0199f46
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage_3|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

ADAM33 NPR1 SRPX

3.91e-051771733d955ea938a1d2fb1b6d68d4997fd454bd632dfc
ToppCellEndothelial|World / shred by cell class for turbinate

ADGRA2 NPR1 SRPX

4.04e-05179173052b2681974be00efb8503fa4e2c85d91d5ebd06
ToppCelldroplet-Liver-nan-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRA2 NPR1 SLC27A3

4.18e-05181173a53f05c4c47465ee62e353716456bd09ab464b23
ToppCellfacs-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l54|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ITGB4 PCSK9 PTPRE

4.25e-05182173d22ab50b135482915687c70e6dad29bfe2bb2c68
ToppCellNS-moderate-d_16-33-Lymphoid-NK|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ADGRA2 ADAM33 SRPX

4.25e-05182173fb503f8ecd013f1f2161a5841572b57cfcddb6fa
ToppCell3'-GW_trimst-1-SmallIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NPR1 SLC27A3 PTPRE

4.25e-05182173fc020d784ab81af80d9331cc322b7c259284eaef
ToppCelldroplet-Liver-nan-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRA2 NPR1 SLC27A3

4.32e-05183173709a486154b3157427deb3b8886b63ac39ea42dd
ToppCelldroplet-Liver-nan-3m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRA2 NPR1 SLC27A3

4.32e-05183173dc06f19f6f80f4c7f13f1f990c1fe0f91ba64ea7
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ITGB4 NPR1 SRPX

4.32e-05183173c1297d8eddfc7132e84ceef14f01b6281f9d0f6a
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-4|TCGA-Bladder / Sample_Type by Project: Shred V9

GABBR2 ADGRA2 ADAM33

4.46e-05185173e1f3f0e974eb3fe1c05018beb9e124c7fb0cbe50
ToppCellControl-Endothelial-Endothelial-Vein|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IGDCC3 ITGB4 NPR1

4.53e-0518617392092f11ecce22c14f244e42c499af0822977e6f
ToppCellP03-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

IGDCC3 ITGB4 NPR1

4.68e-051881735eb107122064f0a99dfd445cc87d3766f7257216
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma-6|TCGA-Breast / Sample_Type by Project: Shred V9

TGFB1 ADGRA2 ADAM33

4.68e-05188173c90669b51e1902fe7726555290c91c92a911df83
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

IGDCC3 ADAM33 PTPRE

4.68e-05188173c66fccdfe68760b8c3efca77e3c25966dc9a8a5f
ToppCelldroplet-Lung-nan-18m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCDHAC2 ITGB4 NPR1

4.68e-05188173405efea75233ecf70f7d19b630230798d817b7f2
ToppCelldroplet-Kidney-nan-3m-Endothelial-kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGDCC3 NPR1 SLC27A3

4.68e-0518817367c04f446fa4528b13a381622e88eb1f314cc6d5
ToppCelldroplet-Kidney-nan-3m-Endothelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGDCC3 NPR1 SLC27A3

4.68e-0518817303a7f6538cfddc230c0eab10c3613929addd7e33
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NPR1 SLC27A3 PTPRE

4.75e-051891730d18ea72bd58d32a8ab9a61cf97f5786642f804b
ToppCell3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADGRA2 NPR1 SRPX

4.83e-05190173d0297d678498e346e56cf95fe9e3db7d3ad3b837
ToppCellPCW_07-8.5-Endothelial-Endothelial_mature-endo_venous_(13)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ITGB4 NPR1 PTPRE

4.90e-0519117354029b68fb78163c969890886ab0f8fb0dcf3c20
ToppCelldroplet-Lung-LUNG-1m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGB4 IGFBPL1 NPR1

4.90e-05191173c379a499dabf3c9ed80f47adbb2d949821c5b053
ToppCelldroplet-Lung-LUNG-1m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGB4 IGFBPL1 NPR1

4.90e-051911739fc674a58f20b47255e4457d5195c8cff17b0414
ToppCelldroplet-Lung-1m-Endothelial-venous_endothelial|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ITGB4 IGFBPL1 NPR1

4.98e-051921731990dc8a81594018a5bf596be99d0b5f0af0f58f
ToppCelldroplet-Lung-1m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ITGB4 IGFBPL1 NPR1

4.98e-05192173845cc9c18b4436b07dd3ce7980052683937546d2
ToppCelldroplet-Lung-1m-Endothelial-venous_endothelial-vein_endothelial_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ITGB4 IGFBPL1 NPR1

4.98e-05192173c72a082c93a8825adbfef37f889ba3a7052f201b
ToppCellPCW_13-14-Endothelial-Endothelial_mature-endo_venous_(13)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ITGB4 NPR1 PTPRE

5.06e-0519317384d1c1b7d3a1cb80f175527e3c89a2c3da7657f7
ToppCellEndothelial-endothelial_cell_of_vein|World / Lineage, Cell type, age group and donor

ITGB4 NPR1 SRPX

5.13e-051941733cbd9622a68e89add90e589867d88c83c5a33476
ToppCell15-Airway-Endothelial|Airway / Age, Tissue, Lineage and Cell class

TGFB1 ITGB4 NPR1

5.13e-05194173ac0e48b0c09a7f57d30dff321b0c30a4c5e16ad9
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_vein|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ITGB4 NPR1 SRPX

5.13e-05194173fc2e0081005c0c496e41197a2d06e4a37708221f
ToppCell15-Airway-Endothelial-Endothelial|Airway / Age, Tissue, Lineage and Cell class

TGFB1 ITGB4 NPR1

5.13e-05194173f3851337a2d17f4acef2cd812a766eb0b503748b
ToppCellTCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical|TCGA-Thryoid / Sample_Type by Project: Shred V9

TGFB1 ITGB4 PTPRE

5.13e-05194173b46c54802b8d1e0a0a17f9ed8e82eaf5e7f4849d
ToppCellBronchial_Biopsy-Mesenchymal-Fibroblasts|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

ADGRA2 ADAM33 SRPX

5.21e-051951735870b2956d50d6550a3174a220a6cc70c5538d70
ToppCellwk_15-18-Endothelial-Blood_vessel_endothelial-Venous_endo|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

ITGB4 NPR1 SRPX

5.21e-05195173cc3d6f98d310e8840ff497d7258c5ccf54e6c624
ToppCellPCW_13-14-Endothelial-Endothelial_mature|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ITGB4 NPR1 PTPRE

5.21e-0519517331353269591c9eee84872838e91995d4a035da46
ToppCellBronchial_Biopsy-Mesenchymal|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

ADGRA2 ADAM33 SRPX

5.29e-05196173d37d821229dce716a05c2a5865415e10f79032de
ToppCellControl-Stromal-Fibroblast|World / Disease state, Lineage and Cell class

ADAM33 NPR1 SRPX

5.29e-051961731ec7a4daa51b3156db97e1fd6cb925ad311bb4b5
ToppCell15-Trachea-Mesenchymal-Mesenchyme_SERPINF1-high|Trachea / Age, Tissue, Lineage and Cell class

ADGRA2 ADAM33 SRPX

5.29e-0519617354aefcebf13704f51de84379e2e22ec0734b9461
ToppCellFibroblast|World / shred by cell class for bronchial biopsy

ADGRA2 ADAM33 SRPX

5.37e-051971738bf9846228b6b6721b10375fe54a2fb389ff64a6
ToppCellwk_20-22-Endothelial-Blood_vessel_endothelial-Venous_endo|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

ITGB4 NPR1 SRPX

5.54e-0519917370e05d7c0c68c28754ce0e72434b205aed6287ae
ToppCelldistal-Endothelial-Vein-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ITGB4 NPR1 SRPX

5.54e-05199173f9fc0482d7ab11f2165b30cce3564b4ff87d61a6
ToppCellSevere-Myeloid-Macrophages-FCN1_high|Severe / Condition, Lineage, Cell class and cell subclass

TGFB1 SLC27A3 PTPRE

5.62e-05200173449623d6786e30d493f68156b3f1ee8caf9265a6
ToppCellParenchyma_COVID-19-Endothelial-TX-Artery|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

ITGB4 NPR1 SRPX

5.62e-0520017334b279804475ea58fbb052b96f44128c082627a9
ToppCellBronchus_Control_(B.)-Stromal-TX-Fibroblasts-2,_SCARA5|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

ADAM33 NPR1 SRPX

5.62e-052001732022df85df94ab8cbb4e80e3fe9894c01051c5e0
ToppCell5'-Adult-Distal_Rectal-Mesenchymal|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAM33 NPR1 SRPX

5.62e-05200173db6281b5d4032116310db379d9175d790994c99c
ToppCellmedial-Endothelial-Vein-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ITGB4 NPR1 SRPX

5.62e-052001733f689029f5bc7db0af50a405f1e252aeec529077
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Transitional_Stromal_3_(C3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAM33 NPR1 SRPX

5.62e-05200173cfea2f9d85646c9b722150551ff2e8fc4f6cc98a
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Artery|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

ITGB4 NPR1 SRPX

5.62e-052001738552cc7a439449b30b59760c3e8667217b9852b5
ToppCellTracheal-10x5prime-Stromal-Fibroblastic-Fibro_adventitial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ADAM33 NPR1 SRPX

5.62e-0520017374ad0ae592252060ee294d7483327d765a6ba1dd
ToppCellmedial-Endothelial-Vein|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ITGB4 NPR1 SRPX

5.62e-052001731163e5f6dfb304c94bf8885629350454f4b6bee8
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Bronchial_vessel-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ITGB4 NPR1 SRPX

5.62e-05200173c55efd997392e99068b673542f56f1a209c5a6c8
ToppCell5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-Transitional_Stromal_3_(C3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAM33 NPR1 SRPX

5.62e-05200173a2bb67a06757f19be3f56f8cb5bb7e2affa5f4ed
ToppCellTracheal-10x5prime-Stromal-Fibroblastic-Fibro_alveolar|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ADAM33 NPR1 SRPX

5.62e-052001733e0041c04e42a47257517dae8707a6454570c256
ToppCellBronchus_Control_(B.)-Stromal-TX|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

ADAM33 NPR1 SRPX

5.62e-0520017369b41f5fb370aa8840a9ad7919d03ef1e57d1b5b
ToppCelldistal-Endothelial-Vein|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ITGB4 NPR1 SRPX

5.62e-052001736acf7afe122f81a95c4c66f4d0878d997b57127a
ToppCellParenchyma_COVID-19-Endothelial-TX-Bronchial_vessel|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

ITGB4 NPR1 SRPX

5.62e-05200173a18817d36b2b30a32e1513d36174bf98dfea2a92
ToppCelldistal-3-Endothelial-Vein|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ITGB4 NPR1 SRPX

5.62e-052001733a5c85bad2e7a9ecf55d90acb04178a343b3f5fd
ToppCellmedial-2-Endothelial-Vein|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ITGB4 NPR1 SRPX

5.62e-0520017349da4e3ff10262a492c2cf566a7f2e35e418bfda
ToppCellControl_saline-Endothelial-Endothelial-Vein|Control_saline / Treatment groups by lineage, cell group, cell type

IGDCC3 ITGB4 NPR1

5.62e-05200173e5f876910bc8cb390d9b46a48d9b6d4d57235551
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Artery-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ITGB4 NPR1 SRPX

5.62e-0520017345c08f1befe78553bbadcc2fcffb6138306638f3
ToppCellBronchus_Control_(B.)-Stromal-TX-Fibroblasts-4|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

ADGRA2 ADAM33 SRPX

5.62e-0520017354b18c92daaa3b3368c0c46134b0c27e10c8dbb0
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Bronchial_vessel|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

ITGB4 NPR1 SRPX

5.62e-0520017371979bbcc035d5b8882f1502b5a8ef248aaba45a
ToppCell5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAM33 NPR1 SRPX

5.62e-0520017310f0c20ba7c71d9e2e177597f85b41cb40f0d878
ToppCellHippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Nxph3-Excitatory_Neuron.Slc17a7.Nxph3-Cplx3-Hs6st2_(Entorhinal_cortex)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

PCSK9 STRC

3.02e-046817201ba0ccc5732189a5c0c32cb7819289102711b93
ToppCellHippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Nxph3-Excitatory_Neuron.Slc17a7.Nxph3-Cplx3-Hs6st2_(Entorhinal_cortex)|Hippocampus / BrainAtlas - Mouse McCarroll V32

PCSK9 STRC

3.02e-046817275e81b353ef313d5e98d5c98d584335f1d1fa658
ToppCellTCGA-Brain-Primary_Tumor-Glioblastoma-Primary_GBM-1|TCGA-Brain / Sample_Type by Project: Shred V9

ADAM33 SLC27A3

6.00e-049617214cad3fae85e41b9f629b8a81a433b652276930c
ToppCellFrontal_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Reln_(Cajal-Retzius)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

IGFBPL1 STRC

8.74e-041161721bfd3b0ec4cb5a04c6dfe7861a544eb277e473a3
ToppCellFrontal_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Reln_(Cajal-Retzius)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

IGFBPL1 STRC

8.74e-04116172a3dcd18807d14e207438f321be62797384fd3907
ToppCellFrontal_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

IGFBPL1 STRC

8.74e-04116172685484ea4cbefb5aff5f0cd999fdfadc5a5676e1
ToppCellEpithelial-Epithelial-D_(Clara-Club_cells)|Epithelial / shred on cell class and cell subclass (v4)

GABBR2 SLC27A3

9.81e-04123172caa1576f1b5eb592d522be61c090ac444e277ac5
ToppCellSubstantia_nigra-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

ADAM33 SRPX

1.05e-031271728c972ea21797ee46d6c67e91cfd2e2e2ce016248
ToppCellTCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Conventional_Leiomyosarcoma-2|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9

GABBR2 IGFBPL1

1.13e-03132172a8e7e7f38af095d63e221bcc06a1e5147bb6e467
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

IGDCC3 STRC

1.18e-031351727b456fa9a5f5ce58976a8f1fad18c0f96a096930
ToppCellfacs-Marrow-B-cells-3m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GABBR2 IGDCC3

1.21e-031371724dcb15de821439011df1bb0bbd7682d674bd725d
ToppCellfacs-Marrow-B-cells-3m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GABBR2 IGDCC3

1.21e-03137172c05ceeb7b483324604cb3f647d2da2b3786071b1
ToppCellE16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-Mature_Fibroblast_2|E16.5-samps / Age Group, Lineage, Cell class and subclass

SRPX SLC27A3

1.23e-0313817205de2cef97c0912fb23f138dd45348f565a14d74
ToppCellPND07-28-samps-Mesenchymal-Myofibroblast-MyoFB-3|PND07-28-samps / Age Group, Lineage, Cell class and subclass

SRPX SLC27A3

1.29e-031411727ae8ead02e5aeb4106c4a30c08a7a061da3a5d6a
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GABBR2 STRC

1.29e-03141172091b5b72811db5fca2314f4a79d467566920e257
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_ALM_Tgfb1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TGFB1 NPR1

1.36e-0314517284d50a13b48d50c16e768422908e371a55972d0e
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Myl1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

IGFBPL1 PTPRE

1.36e-03145172590ba937c741ae67460f303eca88b1cd3ac87f64
ToppCell3'_v3-GI_small-bowel-Lymphocytic_Invariant-Inducer-like-MAIT|GI_small-bowel / Manually curated celltypes from each tissue

TGFB1 PCSK9

1.40e-031471724ba9a86ab7033688a9a2a2dc84c001a49af835b4
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-SMC-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TGFB1 ADGRA2

1.42e-03148172e514b7cf412ddbee249894e089e2204c67bcdbce
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGFBPL1 PTPRE

1.43e-0314917248fca6ae33d7722c024b43ce04f4dbce7b6b424b
ToppCellLPS_only-Hematopoietic_Mast-Mast_cells-T-cells|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GABBR2 TGFB1

1.45e-03150172ccb782fbcb3122266354a112a9a850506664f44d
ToppCelldroplet-Fat-Scat-21m-Myeloid-monocyte|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GABBR2 PTPRE

1.45e-03150172b6e5e04aaf1c5265ac07581868d3159f9292a84c
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage_3|356C / Donor, Lineage, Cell class and subclass (all cells)

NPR1 SRPX

1.55e-03155172e1a20e88b9c0eaf7ca7004acc0eda096d1588563
ToppCell5'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCSK9 STRC

1.57e-03156172d411116d54add2d4fe649a97ac54cb94c085312f
DrugKarakoline [39089-30-0]; Down 200; 10.6uM; MCF7; HT_HG-U133A

GABBR2 ADGRA2 ITGB4 NPR1

9.49e-061991643638_DN
Diseaseautosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)

STRCP1 STRC

3.12e-072172DOID:0110471 (implicated_via_orthology)
DiseaseCirrhosis

TGFB1 NPR1

3.77e-0450172C1623038
DiseaseFibrosis

TGFB1 NPR1

3.77e-0450172C0016059
Diseasechronic obstructive pulmonary disease (is_implicated_in)

TGFB1 ADAM33

5.98e-0463172DOID:3083 (is_implicated_in)
Diseaseliver fibrosis measurement

TGFB1 PCSK9

1.11e-0386172EFO_0010576
DiseaseKidney Diseases

TGFB1 NPR1

1.16e-0388172C0022658
Diseasemyocardial infarction (is_implicated_in)

TGFB1 NPR1

1.47e-0399172DOID:5844 (is_implicated_in)
DiseaseAbortion, Tubal

TGFB1 ITGB4

1.77e-03109172C0000822
DiseaseEarly Pregnancy Loss

TGFB1 ITGB4

1.77e-03109172C3830362
DiseaseMiscarriage

TGFB1 ITGB4

1.77e-03109172C4552766
DiseaseSpontaneous abortion

TGFB1 ITGB4

1.77e-03109172C0000786
Diseasefactor VIII measurement, coronary artery disease

TGFB1 PCSK9

1.90e-03113172EFO_0001645, EFO_0004630
Diseasefactor XI measurement, coronary artery disease

TGFB1 PCSK9

1.97e-03115172EFO_0001645, EFO_0004694
Diseasevon Willebrand factor measurement, coronary artery disease

TGFB1 PCSK9

2.07e-03118172EFO_0001645, EFO_0004629
Diseaseangina pectoris

TGFB1 PCSK9

2.32e-03125172EFO_0003913
Diseaseasthma (is_marker_for)

TGFB1 ADAM33

2.36e-03126172DOID:2841 (is_marker_for)
Diseasehypertension (implicated_via_orthology)

TGFB1 NPR1

2.43e-03128172DOID:10763 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
LLPLLPWLLLLLAPE

ADGRA2

16

Q96PE1
TPLLLLLLLLLLWPV

ADAM33

11

Q9BZ11
RLRLLLLLLLPPLLL

NPR1

11

P16066
PLLAWLLLPLLLLLL

PTPRE

46

P23469
LWPRLLLPLLLLLLP

IGDCC3

16

Q8IVU1
LLLLLLLLSPPLLLL

ATRN

61

O75882
WPLPLLLLLLLLLGP

PCSK9

11

Q8NBP7
MLLWPLLLLLLLLPT

GHDC

1

Q8N2G8
LLLPLLLLLLLPLLP

IGFBPL1

6

Q8WX77
PLLLLLLPLLALLLL

ITGB4

716

P16144
PWLLLLPLLLLLLLL

PCDHAC2

21

Q9Y5I4
ARLLLLLLLPLLLPL

GABBR2

21

O75899
LLLLPPLLLLLLLRV

SRPX

11

P78539
WPLLLLLLLLLLLSF

STRC

6

Q7RTU9
LLPLLLLLPLLLLKL

SLC27A3

6

Q5K4L6
LLLPLLLLKLHLWPQ

SLC27A3

11

Q5K4L6
LRLLLLLLPLLWLLV

TGFB1

6

P01137
WPLLLLLLLLLLLSF

STRCP1

6

A6NGW2