Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nuclease activity	SLFN13 ANGEL1 N4BP1 SLFN11 POLQ HARBI1	1.72e-04	231	71	6	GO:0004518
GeneOntologyMolecularFunction	ATP-dependent activity	DYNC2H1 SLFN13 ABCC8 MYO1F ERCC6L2 SLFN11 RFT1 POLQ DNAH8	3.16e-04	614	71	9	GO:0140657
GeneOntologyBiologicalProcess	cell surface receptor signaling pathway via JAK-STAT	IL10 KIT IL6 IFNA6 PTK6 IFNAR2	4.84e-05	198	68	6	GO:0007259
GeneOntologyBiologicalProcess	regulation of receptor signaling pathway via JAK-STAT	IL10 KIT IL6 IFNA6 IFNAR2	5.79e-05	125	68	5	GO:0046425
GeneOntologyBiologicalProcess	vasculature development	IL10 SP1 SP100 PNPLA6 DYNC2H1 ABCC8 JMJD8 WT1 SMOC2 HECTD1 KIT IL6	6.91e-05	969	68	12	GO:0001944
GeneOntologyBiologicalProcess	cell surface receptor signaling pathway via STAT	IL10 KIT IL6 IFNA6 PTK6 IFNAR2	7.84e-05	216	68	6	GO:0097696
GeneOntologyBiologicalProcess	regulation of receptor signaling pathway via STAT	IL10 KIT IL6 IFNA6 IFNAR2	1.10e-04	143	68	5	GO:1904892
Domain	DUF2075	SLFN13 SLFN11	3.91e-05	3	68	2	IPR018647
Domain	DUF2075	SLFN13 SLFN11	3.91e-05	3	68	2	PF09848
Domain	AlbA_2	SLFN13 SLFN11	2.71e-04	7	68	2	PF04326
Domain	Schlafen	SLFN13 SLFN11	2.71e-04	7	68	2	IPR029684
Domain	Schlafen_AAA_dom	SLFN13 SLFN11	2.71e-04	7	68	2	IPR007421
Domain	DHC_N1	DYNC2H1 DNAH8	3.61e-04	8	68	2	PF08385
Domain	Dynein_heavy_dom-1	DYNC2H1 DNAH8	3.61e-04	8	68	2	IPR013594
Domain	Sp1_fam	SP8 SP1	5.77e-04	10	68	2	IPR030450
Domain	-	IL10 IL6 IFNA6	8.00e-04	50	68	3	1.20.1250.10
Domain	4_helix_cytokine_core	IL10 IL6 IFNA6	8.48e-04	51	68	3	IPR012351
Domain	I-BAR_dom	ARHGAP10 ACAP3	9.93e-04	13	68	2	IPR013606
Domain	Dynein_heavy_chain_D4_dom	DYNC2H1 DNAH8	1.16e-03	14	68	2	IPR024317
Domain	Dynein_HC_stalk	DYNC2H1 DNAH8	1.16e-03	14	68	2	IPR024743
Domain	Dynein_heavy_dom-2	DYNC2H1 DNAH8	1.16e-03	14	68	2	IPR013602
Domain	DHC_N2	DYNC2H1 DNAH8	1.16e-03	14	68	2	PF08393
Domain	MT	DYNC2H1 DNAH8	1.16e-03	14	68	2	PF12777
Domain	AAA_8	DYNC2H1 DNAH8	1.16e-03	14	68	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DYNC2H1 DNAH8	1.16e-03	14	68	2	IPR011704
Domain	AAA_5	DYNC2H1 DNAH8	1.16e-03	14	68	2	PF07728
Domain	DHC_fam	DYNC2H1 DNAH8	1.33e-03	15	68	2	IPR026983
Domain	Dynein_heavy_dom	DYNC2H1 DNAH8	1.33e-03	15	68	2	IPR004273
Domain	Dynein_heavy	DYNC2H1 DNAH8	1.33e-03	15	68	2	PF03028
Domain	4_helix_cytokine-like_core	IL10 IL6 IFNA6	2.49e-03	74	68	3	IPR009079
Domain	-	DYNC2H1 SLFN13 ABCC8 MYO1F ERCC6L2 SLFN11 POLQ DNAH8	5.56e-03	746	68	8	3.40.50.300
Domain	Kazal_2	WFIKKN1 SMOC2	7.60e-03	36	68	2	PF07648
Pubmed	Mast cells control insulitis and increase Treg cells to confer protection against STZ-induced type 1 diabetes in mice.	IL10 KIT IL6	4.73e-07	8	72	3	26234742
Pubmed	Developmental expression of Smoc1 and Smoc2 suggests potential roles in fetal gonad and reproductive tract differentiation.	WT1 SMOC2 KIT	1.01e-06	10	72	3	19842175
Pubmed	Associations of three well-characterized polymorphisms in the IL-6 and IL-10 genes with pneumonia: a meta-analysis.	IL10 IL6	4.23e-06	2	72	2	25708204
Pubmed	More Evidence of the Link of Interleukin-6 and Interleukin-10 with Critical COVID-19: A Report in Mexican Patients.	IL10 IL6	4.23e-06	2	72	2	34931618
Pubmed	Chronic non-bacterial osteomyelitis is associated with impaired Sp1 signaling, reduced IL10 promoter phosphorylation, and reduced myeloid IL-10 expression.	IL10 SP1	4.23e-06	2	72	2	21925952
Pubmed	Correlations of IL-6 and IL-10 gene polymorphisms with childhood acute lymphoblastic leukemia.	IL10 IL6	4.23e-06	2	72	2	32767331
Pubmed	Interleukin-10 genotypes of the -1087 single nucleotide polymorphism influence sp1 expression in periodontitis lesions.	IL10 SP1	4.23e-06	2	72	2	21309719
Pubmed	Mast cell deficiency exacerbates inflammatory bowel symptoms in interleukin-10-deficient mice.	IL10 KIT	4.23e-06	2	72	2	25083083
Pubmed	Serum levels of interleukins 6, 10, and 13 before and after treatment of classic Hodgkin lymphoma.	IL10 IL6	4.23e-06	2	72	2	21466366
Pubmed	Effects of analgesia methods on serum IL-6 and IL-10 levels after cesarean delivery.	IL10 IL6	4.23e-06	2	72	2	25966252
Pubmed	Chlamydia pneumoniae induces interleukin-6 and interleukin-10 in human gingival fibroblasts.	IL10 IL6	4.23e-06	2	72	2	19039953
Pubmed	IL-6, TNF-α, and IL-10 levels/polymorphisms and their association with type 2 diabetes mellitus and obesity in Brazilian individuals.	IL10 IL6	4.23e-06	2	72	2	28225860
Pubmed	Altered expression of interleukin 6 and interleukin 10 as a result of photodynamic therapy in vivo.	IL10 IL6	4.23e-06	2	72	2	9307269
Pubmed	Polymorphisms of interleukin 6 and interleukin 10 in Egyptian people with Behcet's disease.	IL10 IL6	4.23e-06	2	72	2	24703990
Pubmed	Deciphering the balance of IL-6/IL-10 cytokines in severe to critical COVID-19 patients.	IL10 IL6	4.23e-06	2	72	2	35691133
Pubmed	Image-guided thermal ablation of tumors increases the plasma level of interleukin-6 and interleukin-10.	IL10 IL6	4.23e-06	2	72	2	23582441
Pubmed	Association of IL-10 (- 1082 A/G) and IL-6 (- 174 G/C) gene polymorphism with type 2 diabetes mellitus in Ethiopia population.	IL10 IL6	4.23e-06	2	72	2	33858419
Pubmed	Intensive cytokine induction in pandemic H1N1 influenza virus infection accompanied by robust production of IL-10 and IL-6.	IL10 IL6	4.23e-06	2	72	2	22174866
Pubmed	Cytokines and metabolic patterns in pediatric patients with critical illness.	IL10 IL6	4.23e-06	2	72	2	20490277
Pubmed	Independent and joint effects of the IL-6 and IL-10 gene polymorphisms in pulmonary tuberculosis among the Chinese Han population.	IL10 IL6	4.23e-06	2	72	2	25299090
Pubmed	Immune response in Mansonella ozzardi infection modulated by IL-6/IL-10 axis in Amazon region of Brazil.	IL10 IL6	4.23e-06	2	72	2	29032984
Pubmed	Positive affective style covaries with stimulated IL-6 and IL-10 production in a middle-aged community sample.	IL10 IL6	4.23e-06	2	72	2	17548183
Pubmed	[Gene IL6 G(-174)C and gene IL10 G(-1082)A polymorphisms are associated with unfavourable outcomes in patients with acute coronary syndrome].	IL10 IL6	4.23e-06	2	72	2	21090240
Pubmed	Interleukin-6 leads to interleukin-10 production in several human multiple myeloma cell lines. Does interleukin-10 enhance the proliferation of these cells?	IL10 IL6	4.23e-06	2	72	2	19762082
Pubmed	IL-6 and IL-10 Closely Correlate with Bacterial Bloodstream Infection.	IL10 IL6	4.23e-06	2	72	2	32996896
Pubmed	The expression of the Wilms' tumour gene, WT1, in the developing mammalian embryo.	WT1 KIT	4.23e-06	2	72	2	8382938
Pubmed	Evaluating IL-6 and IL-10 as rapid diagnostic tools for Gram-negative bacteria and as disease severity predictors in pediatric sepsis patients in the intensive care unit.	IL10 IL6	4.23e-06	2	72	2	36544765
Pubmed	The effects of IL-6 and IL-10 and their specific antibodies in the acute inflammatory responses induced by carrageenan in the mouse model of pleurisy.	IL10 IL6	4.23e-06	2	72	2	11895333
Pubmed	The Association of Circulatory Cytokines (IL-6 and IL-10) Level with Spontaneous Abortion-a Preliminary Observation.	IL10 IL6	4.23e-06	2	72	2	32789572
Pubmed	Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma.	IL10 IL6	4.23e-06	2	72	2	17875732
Pubmed	Interleukin-6-gene C/G 174 polymorphism in nonagenarian and octogenarian subjects in the BELFAST study. Reciprocal effects on IL-6, soluble IL-6 receptor and for IL-10 in serum and monocyte supernatants.	IL10 IL6	4.23e-06	2	72	2	12714267
Pubmed	Interleukin (IL)-6 and IL-10 Are Up Regulated in Late Stage Trypanosoma brucei rhodesiense Sleeping Sickness.	IL10 IL6	4.23e-06	2	72	2	26090964
Pubmed	IL-6/IL-10 mRNA expression ratio in tumor tissues predicts prognosis in gastric cancer patients without distant metastasis.	IL10 IL6	4.23e-06	2	72	2	36371539
Pubmed	A meta-analysis of differences in IL-6 and IL-10 between people with and without depression: exploring the causes of heterogeneity.	IL10 IL6	4.23e-06	2	72	2	22687336
Pubmed	Targeted Deletion of Interleukin-6 in a Mouse Model of Chronic Inflammation Demonstrates Opposing Roles in Aging: Benefit and Harm.	IL10 IL6	4.23e-06	2	72	2	32585682
Pubmed	IL-6 and IL-10 promoter gene polymorphisms in psoriasis vulgaris.	IL10 IL6	4.23e-06	2	72	2	18311435
Pubmed	Gene-gene interaction between interleukin-6 and interleukin-10 reduces AD risk.	IL10 IL6	4.23e-06	2	72	2	15452323
Pubmed	Longitudinal profiling of inflammatory cytokines and C-reactive protein during uncomplicated and preterm pregnancy.	IL10 IL6	4.23e-06	2	72	2	24807462
Pubmed	Utility of Assessing Cytokine Levels for the Differential Diagnosis of Pneumonia in a Pediatric Population.	IL10 IL6	4.23e-06	2	72	2	28198756
Pubmed	Role of WT1-ZNF224 interaction in the expression of apoptosis-regulating genes.	WT1 ZNF224	4.23e-06	2	72	2	23362234
Pubmed	Phenotype and Polyfunctional Deregulation Involving Interleukin 6 (IL-6)- and IL-10-Producing Monocytes in HIV-Infected Patients Receiving Combination Antiretroviral Therapy Differ From Those in Healthy Older Individuals.	IL10 IL6	4.23e-06	2	72	2	26518043
Pubmed	Influence of cytokine gene polymorphisms on erythropoetin dose requirements in chronic haemodialysis patients.	IL10 IL6	4.23e-06	2	72	2	17875573
Pubmed	Genetic polymorphisms of interleukin 6 and interleukin 10 in Egyptian patients with systemic lupus eythematosus.	IL10 IL6	4.23e-06	2	72	2	26568585
Pubmed	IL-6 and IL-10 are associated with good prognosis in early stage invasive breast cancer patients.	IL10 IL6	4.23e-06	2	72	2	29256156
Pubmed	Effects of insomnia disorder and knee osteoarthritis on resting and pain-evoked inflammatory markers.	IL10 IL6	4.23e-06	2	72	2	25532786
Pubmed	Molecular analysis of WT1 and KIT mutations in patients from an Indian population with de novo acute myeloid leukemia: determination of incidence, distribution patterns, and report of a novel KIT mutation.	WT1 KIT	4.23e-06	2	72	2	21504297
Pubmed	An age-related decline in interleukin-10 may contribute to the increased expression of interleukin-6 in brain of aged mice.	IL10 IL6	4.23e-06	2	72	2	11847480
Pubmed	Polymorphisms of IL-6 174 G/C, IL-10 -592 C/A and risk of HIV/AIDS among North Indian population.	IL10 IL6	4.23e-06	2	72	2	19936625
Pubmed	Preliminary study of the plasma and cerebrospinal fluid concentrations of IL-6 and IL-10 in patients with chronic pain receiving intrathecal opioid infusions by chronically implanted pump for pain management.	IL10 IL6	4.23e-06	2	72	2	20202139
Pubmed	Interleukin-6 and interleukin-10 gene polymorphism, endothelial dysfunction, and postoperative prognosis in patients with peripheral arterial disease.	IL10 IL6	4.23e-06	2	72	2	20385468
Pubmed	Multipotent stromal cells skew monocytes towards an anti-inflammatory interleukin-10-producing phenotype by production of interleukin-6.	IL10 IL6	4.23e-06	2	72	2	23349310
Pubmed	Association of IL-10 (-819T/C, -592A/C and -1082A/G) and IL-6 -174G/C gene polymorphism and the risk of pneumonia-induced sepsis.	IL10 IL6	4.23e-06	2	72	2	27388228
Pubmed	Biochemical and functional interaction between ZNF224 and ZNF255, two members of the Kruppel-like zinc-finger protein family and WT1 protein isoforms.	WT1 ZNF224	4.23e-06	2	72	2	20591825
Pubmed	Serum IL-6, IL-10, and TNFα levels in pediatric sickle cell disease patients during vasoocclusive crisis and steady state condition.	IL10 IL6	4.23e-06	2	72	2	25569375
Pubmed	Cytokine mediated changes of pain sensitivity in predisposition to substance dependence.	IL10 IL6	4.23e-06	2	72	2	29244477
Pubmed	Malnutrition-inflammation syndrome in a hemodialysis population: the influence of polymorphic IL-6-174 and IL-10-1082 genes.	IL10 IL6	4.23e-06	2	72	2	17132891
Pubmed	Diagnostic performance of serum interleukin-6 and interleukin-10 levels and clinical predictors in children with rotavirus and norovirus gastroenteritis.	IL10 IL6	4.23e-06	2	72	2	22592039
Pubmed	Maternal cytokines and disease severity influence pregnancy outcomes in women with rheumatoid arthritis.	IL10 IL6	4.23e-06	2	72	2	26629845
Pubmed	Serum interleukin-6 and -10 levels in patients with gastric cancer.	IL10 IL6	4.23e-06	2	72	2	19562463
Pubmed	Increased Serum Interleukin 10 Levels Are Associated with Increased Disease Activity and Increased Risk of Anti-SS-A/Ro Antibody Positivity in Patients with Systemic Lupus Erythematosus.	IL10 IL6	4.23e-06	2	72	2	37371554
Pubmed	Community-acquired pneumonia in older patients: does age influence systemic cytokine levels in community-acquired pneumonia?	IL10 IL6	4.23e-06	2	72	2	19272082
Pubmed	Aberrant cytokine expression in COVID-19 patients: Associations between cytokines and disease severity.	IL10 IL6	4.23e-06	2	72	2	33840589
Pubmed	Interleukin-10 activates the transcription factor C/EBP and the interleukin-6 gene promoter in human intestinal epithelial cells.	IL10 IL6	4.23e-06	2	72	2	12219016
Pubmed	The association of cytokines genes (IL-6 and IL-10) with the susceptibility to schizophrenia: A systematic review and meta-analysis.	IL10 IL6	4.23e-06	2	72	2	37923001
Pubmed	The transmembrane proteins contribute to immunodeficiencies induced by HIV-1 and other retroviruses.	IL10 IL6	4.23e-06	2	72	2	24445366
Pubmed	Low serum IL-10 concentrations and loss of regulatory association between IL-6 and IL-10 in adults with major depression.	IL10 IL6	4.23e-06	2	72	2	19552919
Pubmed	Wilms' tumor protein Wt1 regulates the Interleukin-10 (IL-10) gene.	IL10 WT1	4.23e-06	2	72	2	20974136
Pubmed	Prolonged restraint stress increases IL-6, reduces IL-10, and causes persistent depressive-like behavior that is reversed by recombinant IL-10.	IL10 IL6	4.23e-06	2	72	2	23520517
Pubmed	Exaggerated expression of skeletal muscle-derived interleukin-6, but not TNFalpha, in mice lacking interleukin-10.	IL10 IL6	4.23e-06	2	72	2	18565597
Pubmed	Interleukin-10 and interleukin-6 gene polymorphisms as risk factors for Alzheimer's disease.	IL10 IL6	4.23e-06	2	72	2	15212825
Pubmed	IL-6 and IL-10 levels in the umbilical cord blood of newborns with a history of crack/cocaine exposure in utero: a comparative study.	IL10 IL6	4.23e-06	2	72	2	27074340
Pubmed	IL-6 and IL-10 promoter gene polymorphisms of patients and donors of allogeneic sibling hematopoietic stem cell transplants associate with the risk of acute graft-versus-host disease.	IL10 IL6	4.23e-06	2	72	2	15993715
Pubmed	Association of interleukin-6 and interleukin-10 expression, gene polymorphisms, and Takayasu arteritis in a Chinese Han population.	IL10 IL6	4.23e-06	2	72	2	30171380
Pubmed	IL-6 and IL-10 are associated with disease severity and higher comorbidity in adults with COVID-19.	IL10 IL6	4.23e-06	2	72	2	33839002
Pubmed	Polymorphisms in interleukin-6 and interleukin-10 may be associated with risk of preeclampsia.	IL10 IL6	4.23e-06	2	72	2	28252161
Pubmed	Haplotypes of IL6 and IL10 and susceptibility to human T lymphotropic virus type I infection among children.	IL10 IL6	4.23e-06	2	72	2	17083041
Pubmed	An interleukin 6-based genetic risk score strengthened with interleukin 10 polymorphisms associated with long-term kidney allograft outcomes.	IL10 IL6	4.23e-06	2	72	2	36453708
Pubmed	IL-6 and IL-10 Are Associated With Gram-Negative and Gram-Positive Bacteria Infection in Lymphoma.	IL10 IL6	4.23e-06	2	72	2	35432366
Pubmed	Analysis of serum and cerebrospinal fluid cytokine levels in subacute sclerosing panencephalitis in Papua New Guinea.	IL10 IL6	4.23e-06	2	72	2	16413199
Pubmed	Genetic variants in IL-6 and IL-10 genes and susceptibility to hepatocellular carcinoma in HCV infected patients.	IL10 IL6	4.23e-06	2	72	2	28340949
Pubmed	Correlations between indicators of interleukin-10 and interleukin-6 in patients with periodic disease.	IL10 IL6	4.23e-06	2	72	2	30701854
Pubmed	Identification and predictive value of interleukin-6+ interleukin-10+ and interleukin-6- interleukin-10+ cytokine patterns in ST-elevation acute myocardial infarction.	IL10 IL6	4.23e-06	2	72	2	22931953
Pubmed	Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease.	IL10 IL6	4.23e-06	2	72	2	19698145
Pubmed	Association of polymorphisms G(-174)C in IL-6 gene and G(-1082)A in IL-10 gene with traditional cardiovascular risk factors in patients with coronary artery disease.	IL10 IL6	4.23e-06	2	72	2	25296499
Pubmed	Serum levels of interleukins IL-6 and IL-10 in individuals with posttraumatic stress disorder in a population-based sample.	IL10 IL6	4.23e-06	2	72	2	29179015
Pubmed	Serum interleukin 6 and 10 levels in Takotsubo cardiomyopathy: Increased admission levels may predict adverse events at follow-up.	IL10 IL6	4.23e-06	2	72	2	27680775
Pubmed	Critical role of IL-10 in the induction of low zone tolerance to contact allergens.	IL10 KIT	4.23e-06	2	72	2	12865418
Pubmed	Mast cell IL-6 improves survival from Klebsiella pneumonia and sepsis by enhancing neutrophil killing.	KIT IL6	4.23e-06	2	72	2	18832718
Pubmed	Inverse production of IL-6 and IL-10 by abdominal aortic aneurysm explant tissues in culture.	IL10 IL6	4.23e-06	2	72	2	22445549
Pubmed	IL-6 and IL-10 gene polymorphisms in patients with aggressive periodontitis: effects on GCF, serum and clinic parameters.	IL10 IL6	4.23e-06	2	72	2	28099578
Pubmed	LPS induces IL-10 production by human alveolar macrophages via MAPKinases- and Sp1-dependent mechanisms.	IL10 SP1	4.23e-06	2	72	2	17916230
Pubmed	[The association between single-nucleotide polymorphisms in IL6, IL10 genes and the susceptibility to primary hepatic carcinoma in Shunde District of Foshan City].	IL10 IL6	4.23e-06	2	72	2	28763918
Pubmed	Relation of anti- to pro-inflammatory cytokine ratios with acute myocardial infarction.	IL10 IL6	4.23e-06	2	72	2	20195402
Pubmed	Cytokine profiles in acute myeloid leukemia patients at diagnosis: survival is inversely correlated with IL-6 and directly correlated with IL-10 levels.	IL10 IL6	4.23e-06	2	72	2	23357299
Pubmed	Periodontal disease progression and gene polymorphisms: results after 3 years of active periodontal treatment.	IL10 IL6	4.23e-06	2	72	2	35686958
Pubmed	Diagnostic and Prognostic Potential of Exosomal Cytokines IL-6 and IL-10 in Polytrauma Patients.	IL10 IL6	4.23e-06	2	72	2	37511589
Pubmed	Cocaine abuse and effects in the serum levels of cytokines IL-6 and IL-10.	IL10 IL6	4.23e-06	2	72	2	26679059
Pubmed	The evaluation of the relationship between serum levels of Interleukin-6 and Interleukin-10 and metabolic acidosis in hemodialysis patients.	IL10 IL6	4.23e-06	2	72	2	28098099
Pubmed	Differences in innate cytokine responses between European and African children.	IL10 IL6	4.23e-06	2	72	2	24743542
Pubmed	A 1-year follow-up study on immunological changes following deep brain stimulation in patients with epilepsy.	IL10 IL6	4.23e-06	2	72	2	34215817
Cytoband	4q31.23	ARHGAP10 IQCM	5.07e-05	7	72	2	4q31.23
GeneFamily	Schlafen family	SLFN13 SLFN11	1.62e-04	7	51	2	1110
GeneFamily	Zinc fingers C2H2-type\|Sp transcription factors	SP8 SP1	2.77e-04	9	51	2	755
GeneFamily	Interferons	IL6 IFNA6	3.67e-03	32	51	2	598
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	SP8 SP1 ZNF566 WT1 ZIM2 ZNF84 ZNF224	3.83e-03	718	51	7	28
GeneFamily	Endogenous ligands\|Interleukins	IL10 IL6	6.54e-03	43	51	2	601
Coexpression	GSE5542_UNTREATED_VS_IFNA_TREATED_EPITHELIAL_CELLS_24H_UP	PNPLA6 SLFN13 ARHGAP10 MYO1F SLFN11 ANKRD27	1.60e-05	200	70	6	M6524
Coexpression	FIGUEROA_AML_METHYLATION_CLUSTER_1_UP	TBC1D31 GPR149 WT1 GAN N4BP1	1.91e-05	122	70	5	M2159
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP10 ABCC8 ADAM33 SMOC2 NPAS4 RCAN2	6.50e-07	190	72	6	562ee3b025c29edf07b8b344323edb49d82f1c7e
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP10 ABCC8 ADAM33 SMOC2 NPAS4 RCAN2	6.50e-07	190	72	6	f5fb989afabb49d64d91324570cd8c80a4b9e67d
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-3_VIP_SSTR1\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 GPR149 ADAM33 SSTR1 KIT	8.28e-06	170	72	5	667443062882642211ad116043775ef8eda38859
ToppCell	Transverse-(2)_B_cell-(24)_B_cell_cycling\|Transverse / shred on region, Cell_type, and subtype	PEG10 JMJD8 CCDC106 POLQ IL6	1.81e-05	200	72	5	e3f9736227151f23f0e331eec0a7a15ce464b517
ToppCell	Transverse-B_cell-B_cell_cycling\|Transverse / Region, Cell class and subclass	PEG10 JMJD8 CCDC106 POLQ IL6	1.81e-05	200	72	5	0e270f8019d9f22068ca426d661937262a5cd331
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-OPRM1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SP8 GPR149 ADAM33 SMOC2 KIT	1.81e-05	200	72	5	559cf4001a3f985c8357f0102b34fab2e34d2a04
ToppCell	distal-3-mesenchymal-Airway_Smooth_Muscle\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	LNP1 KCNC4 ADAM33 SMOC2 RCAN2	1.81e-05	200	72	5	4072cfb3047954f507289587b4bfaf1526936992
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-OPRM1-L1-4\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SP8 GPR149 ADAM33 SMOC2 KIT	1.81e-05	200	72	5	cc0d639d38eb99414ba8b54d3000701962394465
ToppCell	LPS-IL1RA-Endothelial-Epi-like-Alv_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SP1 SMOC2 KIT RCAN2	7.41e-05	138	72	4	5f8ac8f67e34a7cf560099208e6884102532391e
ToppCell	COVID-19_Mild-PLT_3\|World / Disease Group and Platelet Clusters	DLGAP1 ELMO3 DYNC2H1 PEG10	9.47e-05	147	72	4	9d3271aa735ddb6f32ab864d7afcfb0f8754383b
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SP8 CRACR2A PEG10 KIT	1.16e-04	155	72	4	105d59d8a1bb8cb37eef2c1767d737b2108ac7c5
ToppCell	Paneth_cell\|World / shred on cell type and cluster	DLGAP1 CRACR2A SMOC2 DNAH8	1.31e-04	160	72	4	d787b7cdb8c3f677ac9c4934a5df9cc194df3987
ToppCell	C_07\|World / shred on cell type and cluster	DLGAP1 CRACR2A SMOC2 DNAH8	1.31e-04	160	72	4	b7c5a8a1c85da92e1945721b6887b32fad7b76b8
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-4_VIP_LGI2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 GPR149 ADAM33 KIT	1.34e-04	161	72	4	c210f3fd7724d46c6aa92b2d56adf68164d62543
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP10 SMOC2 NPAS4 RCAN2	1.48e-04	165	72	4	4f83ac71efc57be3668d8db1e62bad05dc6a5e2b
ToppCell	Ionocyte\|World / shred by cell class for turbinate	GPRC6A SSTR1 KIT RCAN2	1.48e-04	165	72	4	0cb2199b87f17ece743fb2652b2f448dfa78ae0b
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP10 SMOC2 NPAS4 RCAN2	1.48e-04	165	72	4	cd8de98af8a1a8a6c81d71fae807cc07f319f4c9
ToppCell	343B-Lymphocytic-ILC\|343B / Donor, Lineage, Cell class and subclass (all cells)	SP100 TBC1D31 HEATR5A NUP205	1.51e-04	166	72	4	a54377c703efff42d2cc1a8fdb610facc58053dd
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-3_VIP_SSTR1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GPR149 ADAM33 SSTR1 KIT	1.55e-04	167	72	4	73720fbffdffe0d28ce4e8c7967e968d870b1f56
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-T_cells-Th17\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LNP1 TBC1D31 CRACR2A KIT	1.58e-04	168	72	4	97bf074b91c9ae0064edc31fa4a2658ffdcfefa3
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-4_VIP_CHRNA2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 GPR149 ADAM33 KIT	1.58e-04	168	72	4	11ab08e373abe4bbd0f2134db38a2e8efa0eb159
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DYNC2H1 ARHGAP10 FARP1 ADAM33	1.62e-04	169	72	4	c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-4_VIP_CHRNA2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 GPR149 BOD1L2 KIT	1.66e-04	170	72	4	45584bd9953257dd28c06ffbbfe4395ce7b1b88d
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-3_VIP_SSTR1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 ADAM33 SSTR1 KIT	1.73e-04	172	72	4	458fe1ae92620882dbc95c989a6da9b2ca216b5b
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-4_VIP_LGI2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 GPR149 ADAM33 KIT	1.81e-04	174	72	4	ef9232610829cd3a34f0c0e284cdbee449c19c00
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-3_VIP_SSTR1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 ADAM33 SSTR1 KIT	1.93e-04	177	72	4	fdab7b7ddfb06f913b8224c0c80574dc3cf4cbd4
ToppCell	3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SP8 GPRC6A KIT RCAN2	1.93e-04	177	72	4	6d89042bda8e244babb68929e84b25edcb545a77
ToppCell	3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SP8 GPRC6A KIT RCAN2	1.93e-04	177	72	4	daaccf1249dcf816df4caca695a944f53078291a
ToppCell	3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SP8 GPRC6A KIT RCAN2	1.93e-04	177	72	4	338bdda26796bf4e16072878c070212d1006cf57
ToppCell	facs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TBC1D31 ABCC8 POLQ NPAS4	1.93e-04	177	72	4	8abdf1d970b2f15e17e185f3e612dd5065c88757
ToppCell	3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SP8 GPRC6A KIT RCAN2	1.93e-04	177	72	4	c5a16f984c836dbf7d0faf061677844167ab612a
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic-T_cells-LTi-like_NCR+_ILC3\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TBC1D31 ARHGAP10 KIT ANKRD27	1.98e-04	178	72	4	0b59e3d75b143bd7bf91a7800a49699c51e68c5a
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBXO10 EXOC3L4 DNAH8 ACAP3	2.02e-04	179	72	4	025d414ec88d5680d99c8173e70ee3bb0b694f74
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-4_VIP_LGI2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 GPR149 ADAM33 KIT	2.02e-04	179	72	4	8dd10e3a9ab39d9a770cecac6e2ed3676b79e906
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 GPR149 ADAM33 SMOC2	2.06e-04	180	72	4	c6030e725e3d86d5d74a1676330c77ffeceb324f
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-5_VIP_TOX2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 GPR149 ADAM33 KIT	2.11e-04	181	72	4	35bcdcd2651149692e5b150e887c0f450c81d2d4
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-2_VIP_PPAPDC1A\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 GPR149 ADAM33 KIT	2.11e-04	181	72	4	42f5a645beeb5a1a746d79ea7fe7fd3786fd35ad
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-5_VIP_TOX2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 GPR149 ADAM33 KIT	2.15e-04	182	72	4	3d7a8d2ee2137b098248597058974ef5ae09c19e
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 GPR149 ADAM33 KIT	2.15e-04	182	72	4	420a8fd30543e37a66ba0786215d056d308660d0
ToppCell	cellseq-Epithelial-Epithelial_Neuro-Secretory-Ionocyte\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CRACR2A GPRC6A KIT RCAN2	2.15e-04	182	72	4	6e7dac78dc030f74e546b9f6db07556e9bb13ac2
ToppCell	Pericytes-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	KCNC4 ADAM33 SMOC2 NPAS4	2.15e-04	182	72	4	46c213597445b1f4f09dc367f27702d24b201daf
ToppCell	21-Trachea-Mesenchymal-Mesenchyme_SERPINF1-high\|Trachea / Age, Tissue, Lineage and Cell class	ABCC8 WT1 ADAM33 RCAN2	2.15e-04	182	72	4	354dcdb01360597f68c4fe157a682aee1c0b8bb1
ToppCell	cellseq-Epithelial-Epithelial_Neuro-Secretory-Ionocyte-Ionocyte\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CRACR2A GPRC6A KIT RCAN2	2.15e-04	182	72	4	cd972d30519db706477c6b0c901165b81b74abed
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Cplx3\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SP8 CRACR2A GPR149	2.17e-04	72	72	3	0bc1df0405fe854e0364f44b9dacc39b115a9b77
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L3-6_VIP_KCTD13\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PEG10 GPR149 ADAM33 SMOC2	2.20e-04	183	72	4	f06c06c75aab55fa8c803665afaa399446aec5af
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 GPR149 ADAM33 KIT	2.24e-04	184	72	4	32473dbdb2de66391157c5814ef34e790806e4f2
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Proliferating_Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBC1D31 WFIKKN1 POLQ NUP205	2.24e-04	184	72	4	16aa8e88bdd51b1d132d5cf33c29963b384a8bae
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 GPR149 ADAM33 KIT	2.29e-04	185	72	4	cefd81adb480c027545a5c78dcd05669783717f4
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 GPR149 ADAM33 KIT	2.29e-04	185	72	4	bdfa8c284bbc5e85c806327fbb7778cf16242a38
ToppCell	Control-Epithelial-Mesothelial\|Epithelial / Disease state, Lineage and Cell class	WT1 ADAM33 SMOC2 SSTR1	2.29e-04	185	72	4	0af540323c0113203ba6c1a4cb32d2fb9cf79d39
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-4_VIP_CHRNA2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 GPR149 ADAM33 KIT	2.29e-04	185	72	4	3189e91fe26df59bd605d2b6223ceb1779daf0b8
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1_VIP_PCDH20\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 ADAM33 SMOC2 KIT	2.34e-04	186	72	4	531774f2ba8bef5ed355edc86c670bb97ae85900
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 GPR149 ADAM33 KIT	2.38e-04	187	72	4	ae2ee6f8e5c37cb88a67f3e742cf86e57657bfaf
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 GPR149 ADAM33 KIT	2.43e-04	188	72	4	6ee3f8f94ea7bdf652c9575fc65bff08070093a4
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 GPR149 ADAM33 KIT	2.43e-04	188	72	4	c66fccdfe68760b8c3efca77e3c25966dc9a8a5f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP10 ADAM33 SMOC2 RCAN2	2.43e-04	188	72	4	b2d68a32314e9b099ed74d974079ad96359d1ae3
ToppCell	343B-Lymphocytic-ILC-ILC-1\|343B / Donor, Lineage, Cell class and subclass (all cells)	TBC1D31 HEATR5A SLFN11 NUP205	2.43e-04	188	72	4	8f6b45ad82bde65e044d17f0edbc3db90d457915
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP10 ADAM33 NPAS4 RCAN2	2.48e-04	189	72	4	127ad2ba3e794df8cce2eee3e4171bccb5aad51b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP10 ADAM33 NPAS4 RCAN2	2.48e-04	189	72	4	2cfb4d12f75678d1619f4743838a0e954bd57761
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ARHGAP10 WT1 ADAM33 SMOC2	2.53e-04	190	72	4	0fea33f2dc1efa23aaa2da1c318482a52a313ff1
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	KCNC4 ADAM33 NPAS4 RCAN2	2.53e-04	190	72	4	d6b3a92119b210974a32af3fe9875d60eb02761e
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 GPR149 ADAM33 KIT	2.58e-04	191	72	4	764c3a8829ae1253a0790744138266e81fc075ec
ToppCell	(04)_Pre-ciliated\|World / shred by cell type and Timepoint	TBC1D31 HEATR5A DNAH8 NUP205	2.58e-04	191	72	4	37cf121e6e80760c8519075b7845b9029958a988
ToppCell	Mesenchymal-vascular_smooth_muscle_cell\|World / Lineage, Cell type, age group and donor	KCNC4 ADAM33 NPAS4 RCAN2	2.58e-04	191	72	4	fd89fbc62aa1c73e0f659991e3bd726a0c97bd68
ToppCell	COVID-19-lung-Macrophage_PPARGhi_CD5Lhi\|lung / Disease (COVID-19 only), tissue and cell type	PNPLA6 ARHGAP10 SLC22A15 MYO1F	2.58e-04	191	72	4	dab953682b8c9ed680a799161f837f792a7e4f33
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 GPR149 ADAM33 KIT	2.64e-04	192	72	4	3abee376c37c3646da33ac381aa63d50a01607a6
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP10 ADAM33 SMOC2 RCAN2	2.64e-04	192	72	4	24e2f15f5767a97eb3b389922bcfd7b13805e1ce
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 GPR149 ADAM33 SMOC2	2.64e-04	192	72	4	025fac36b862f9ca7f96fb4a1946c44ba7cbc382
ToppCell	3'-Child09-12-SmallIntestine-Mesenchymal-Pericytes\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARHGAP10 ABCC8 SMOC2 RCAN2	2.64e-04	192	72	4	7aadc7c5bd03274f9861dde2febda5c37f8afc9c
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 GPR149 ADAM33 KIT	2.64e-04	192	72	4	6a252e298f8a454623fa9c1c893a7a45a886d694
ToppCell	343B-Lymphocytic-ILC-ILC-1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TBC1D31 HEATR5A SLFN11 NUP205	2.64e-04	192	72	4	445985fe1bcd33e4f0a1704b27988fbfc9334538
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SP100 PEG10 SMOC2 IL6	2.69e-04	193	72	4	7cd9671e0ac64f7f3607f564485c63abbb7e7a63
ToppCell	Immune-alveolar_macrophage_(MARCO_positive)\|World / Lineage, Cell type, age group and donor	PNPLA6 ARHGAP10 SLC22A15 MYO1F	2.80e-04	195	72	4	f92114ef995e690a3bedc62c89c5fd6773d0d9f7
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-Transitional_Stromal_3_(C3+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	WT1 ADAM33 SMOC2 IL6	2.80e-04	195	72	4	fc43cd295f2cc3f6e9442232e028944f011c82cc
ToppCell	5'-Adult-Appendix\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SP100 WT1 SMOC2 IL6	2.85e-04	196	72	4	a579211ef14f348d0c5a290553150222dfbf1515
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Macrophage_alveolar-Macro_alv_dividing\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PNPLA6 GPR85 SLFN11 POLQ	2.91e-04	197	72	4	d669d90c3f9e98b41bcbc49dbdc5698e0b42597c
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-fibroblastic\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PEG10 WT1 SMOC2 IL6	2.91e-04	197	72	4	6668f0da54f3bf96769275e668cd57e00b8a5ef9
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PEG10 WT1 SMOC2 IL6	2.91e-04	197	72	4	7c275a2ac24a9a4f83fceda93a067e754837102f
ToppCell	356C-Fibroblasts-Fibroblast-J_(Lipofibroblast)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	IL10 PEG10 WT1 IL6	3.02e-04	199	72	4	f4fdf94c561dca35bb17766d908c5030655f43eb
ToppCell	Tracheal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_smooth_pulmonary\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	LNP1 ARHGAP10 SMOC2 RCAN2	3.02e-04	199	72	4	056a28c36cd58dc695a5ae6f29b62135d6aad819
ToppCell	Tracheal-10x3prime_v2-Stromal-Myofibroblastic\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	LNP1 ARHGAP10 SMOC2 RCAN2	3.02e-04	199	72	4	534dcfe8b65ad92bb8d749d1c7036ad4807e09cd
ToppCell	Transverse-T_cell-Tfh\|T_cell / Region, Cell class and subclass	DLGAP1 PNPLA6 ANGEL1 USP21	3.02e-04	199	72	4	33ffea12b8228e0b5bd8942531c3b21d24224725
ToppCell	356C-Fibroblasts-Fibroblast-J_(Lipofibroblast)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	IL10 PEG10 WT1 IL6	3.02e-04	199	72	4	c0fe99ed906d0eb99cccdab9a1fa32c17b3542e7
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron-Neuron\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SSTR1 KIT NPAS4 RCAN2	3.08e-04	200	72	4	2f481e2fd248c02a5aa2e0248c16808df142fed2
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_2-TYR-L2-5\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SP8 GPR149 ADAM33 KIT	3.08e-04	200	72	4	04954fbe1e2264077228bb582c9a5897a70e6da2
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron-Neuron-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SSTR1 KIT NPAS4 RCAN2	3.08e-04	200	72	4	bd4b9f6b37f4a3c960c4149cf0cfd2caf3327d2d
ToppCell	Biopsy_Other_PF-Mesenchymal-PLIN2+_Fibroblasts\|Biopsy_Other_PF / Sample group, Lineage and Cell type	WT1 ADAM33 SMOC2 IL6	3.08e-04	200	72	4	0aa316b71f195ecf17ee897e307f8928a755a637
ToppCell	Neuronal-Inhibitory-iA\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SP8 GPR149 ADAM33 KIT	3.08e-04	200	72	4	5ef4a3dc18a44292184a59ced916183c0699b01e
ToppCell	mild-B_intermediate\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SP100 SMOC2 DNAH8 IL6	3.08e-04	200	72	4	fe815824e9e4be3f3db73610e3814a7fd533da65
ToppCell	distal-mesenchymal-Airway_Smooth_Muscle-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	LNP1 ADAM33 SMOC2 RCAN2	3.08e-04	200	72	4	bc969a956f62570419a5faaf0ab0fd17b343c5ca
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_2-TYR\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SP8 GPR149 ADAM33 KIT	3.08e-04	200	72	4	bfdafb024a7b20d46837b2e6480dd4929253cd62
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SSTR1 KIT NPAS4 RCAN2	3.08e-04	200	72	4	dc674124475edf83908b51a4e1454bc2dc4f06fa
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	WT1 ADAM33 SMOC2 IL6	3.08e-04	200	72	4	74e74123ea7bf38d337a3a0248a6a51437c6ab42
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SP8 GPR149 ADAM33 KIT	3.08e-04	200	72	4	75649534a98bc738fca62d071de0978dc61eb24f
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2.Synpr-Crispld2_(Neuron.Gad1Gad2.Synpr-Crispld2)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SP8 CRACR2A IQCM	3.18e-04	82	72	3	7f0ee8dafc37c3628506397f88fbb98fc6420bfb
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2.Synpr-Crispld2_(Neuron.Gad1Gad2.Synpr-Crispld2)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SP8 CRACR2A IQCM	3.18e-04	82	72	3	c8242d273513e99107c154afb489980d11008555
Disease	retinal artery occlusion (is_implicated_in)	IL10 IL6	5.55e-06	2	70	2	DOID:8483 (is_implicated_in)
Disease	thrombocytopenia (is_marker_for)	IL10 IL6	1.66e-05	3	70	2	DOID:1588 (is_marker_for)
Disease	glucosephosphate dehydrogenase deficiency (is_implicated_in)	IL10 IL6	1.66e-05	3	70	2	DOID:2862 (is_implicated_in)
Disease	anogenital venereal wart (is_marker_for)	IL10 IL6 IFNA6	3.20e-05	26	70	3	DOID:11168 (is_marker_for)
Disease	Bright Disease	IL10 WT1 IL6	5.48e-05	31	70	3	C1704377
Disease	Glomerulonephritis	IL10 WT1 IL6	5.48e-05	31	70	3	C0017658
Disease	otitis media (is_implicated_in)	IL10 IL6	5.52e-05	5	70	2	DOID:10754 (is_implicated_in)
Disease	lymphoplasmacytic lymphoma (is_implicated_in)	IL10 IL6	5.52e-05	5	70	2	DOID:0060901 (is_implicated_in)
Disease	Entamoeba histolytica Infection	IL10 IL6	8.27e-05	6	70	2	C4316791
Disease	diffuse scleroderma (is_marker_for)	IL10 IL6	8.27e-05	6	70	2	DOID:1580 (is_marker_for)
Disease	Entamoebiasis	IL10 IL6	8.27e-05	6	70	2	C0014324
Disease	Pleurisy	IL10 IL6	8.27e-05	6	70	2	C0032231
Disease	non-alcoholic steatohepatitis (is_implicated_in)	IL10 IL6	8.27e-05	6	70	2	DOID:0080547 (is_implicated_in)
Disease	sciatic neuropathy (biomarker_via_orthology)	IL10 KCNC4 ABCC8 IL6	9.22e-05	99	70	4	DOID:11446 (biomarker_via_orthology)
Disease	hepatitis B (is_implicated_in)	IL10 IL6 IFNAR2	9.38e-05	37	70	3	DOID:2043 (is_implicated_in)
Disease	Thymic Carcinoma	CYLD KIT	1.16e-04	7	70	2	C0205969
Disease	severe acute respiratory syndrome (biomarker_via_orthology)	IL10 IL6	1.54e-04	8	70	2	DOID:2945 (biomarker_via_orthology)
Disease	Hodgkin's lymphoma (is_marker_for)	IL10 IL6	1.54e-04	8	70	2	DOID:8567 (is_marker_for)
Disease	Diabetes Mellitus, Sudden-Onset	IL10 ABCC8 IL6	1.58e-04	44	70	3	C4554117
Disease	Diabetes Mellitus, Ketosis-Prone	IL10 ABCC8 IL6	1.58e-04	44	70	3	C3837958
Disease	Diabetes, Autoimmune	IL10 ABCC8 IL6	1.58e-04	44	70	3	C0205734
Disease	Brittle diabetes	IL10 ABCC8 IL6	1.58e-04	44	70	3	C0342302
Disease	Diabetes Mellitus, Insulin-Dependent	IL10 ABCC8 IL6	1.69e-04	45	70	3	C0011854
Disease	aggressive periodontitis (is_implicated_in)	IL10 IL6	1.98e-04	9	70	2	DOID:1474 (is_implicated_in)
Disease	Leishmaniasis	IL10 IL6	1.98e-04	9	70	2	C0023281
Disease	adult T-cell leukemia/lymphoma (is_marker_for)	IL10 IL6	1.98e-04	9	70	2	DOID:0050523 (is_marker_for)
Disease	disseminated intravascular coagulation (is_marker_for)	IL10 IL6	2.47e-04	10	70	2	DOID:11247 (is_marker_for)
Disease	Peripheral Nervous System Diseases	PNPLA6 GAN IL6	2.91e-04	54	70	3	C4721453
Disease	hyperinsulinism (is_implicated_in)	ABCC8 IL6	3.61e-04	12	70	2	DOID:2018 (is_implicated_in)
Disease	lung disease (implicated_via_orthology)	IL10 IL6	4.25e-04	13	70	2	DOID:850 (implicated_via_orthology)
Disease	uveitis (is_marker_for)	IL10 IL6	4.25e-04	13	70	2	DOID:13141 (is_marker_for)
Disease	uveitis (is_implicated_in)	IL10 IL6	4.25e-04	13	70	2	DOID:13141 (is_implicated_in)
Disease	Leishmaniasis, Visceral	IL10 IL6	4.25e-04	13	70	2	C0023290
Disease	Graves' disease (is_marker_for)	IL10 IL6	5.71e-04	15	70	2	DOID:12361 (is_marker_for)
Disease	Autoimmune Chronic Hepatitis	IL10 IL6	7.37e-04	17	70	2	C0241910
Disease	major depressive disorder (is_implicated_in)	IL10 IL6	7.37e-04	17	70	2	DOID:1470 (is_implicated_in)
Disease	otitis media (biomarker_via_orthology)	IL10 IL6	7.37e-04	17	70	2	DOID:10754 (biomarker_via_orthology)
Disease	respiratory syncytial virus infectious disease (is_marker_for)	IL10 IL6	8.28e-04	18	70	2	DOID:1273 (is_marker_for)
Disease	Sjogren's syndrome (is_implicated_in)	IL10 IL6	8.28e-04	18	70	2	DOID:12894 (is_implicated_in)
Disease	lung disease (is_marker_for)	IL10 IL6	1.24e-03	22	70	2	DOID:850 (is_marker_for)
Disease	Hepatic Form of Wilson Disease	IL10 IL6	1.48e-03	24	70	2	C1527352
Disease	Hepatolenticular Degeneration	IL10 IL6	1.48e-03	24	70	2	C0019202
Disease	Mammary Carcinoma, Human	IL10 DYNC2H1 WT1 ADAM33 KIT IL6	1.54e-03	525	70	6	C4704874
Disease	Mammary Neoplasms, Human	IL10 DYNC2H1 WT1 ADAM33 KIT IL6	1.54e-03	525	70	6	C1257931
Disease	Mammary Neoplasms	IL10 DYNC2H1 WT1 ADAM33 KIT IL6	1.57e-03	527	70	6	C1458155
Disease	Colitis	IL10 IL6	1.61e-03	25	70	2	C0009319
Disease	Breast Carcinoma	IL10 DYNC2H1 WT1 ADAM33 KIT IL6	1.75e-03	538	70	6	C0678222
Disease	non-alcoholic fatty liver disease (is_marker_for)	IL10 IL6	1.87e-03	27	70	2	DOID:0080208 (is_marker_for)
Disease	TYPE 2 DIABETES MELLITUS	ABCC8 IL6	2.02e-03	28	70	2	125853
Disease	hepatitis C (is_implicated_in)	IL10 IL6	2.02e-03	28	70	2	DOID:1883 (is_implicated_in)
Disease	pneumonia (is_marker_for)	IL10 IL6	2.02e-03	28	70	2	DOID:552 (is_marker_for)
Disease	acute myocardial infarction (biomarker_via_orthology)	IL10 IL6	2.02e-03	28	70	2	DOID:9408 (biomarker_via_orthology)
Disease	Type 2 diabetes mellitus	ABCC8 IL6	2.02e-03	28	70	2	cv:C0011860
Disease	Malignant mesothelioma	WT1 KIT IL6	2.24e-03	109	70	3	C0345967
Disease	Crohn's disease (is_implicated_in)	IL10 IL6	2.31e-03	30	70	2	DOID:8778 (is_implicated_in)
Disease	Hyperglycemia, Postprandial	SP1 IL6	2.31e-03	30	70	2	C1855520
Disease	NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE	WT1 NUP205	2.31e-03	30	70	2	C1868672
Disease	Hyperglycemia	SP1 IL6	2.31e-03	30	70	2	C0020456

Protein segments in the cluster

Peptide	Gene	Start	Entry
FRRSSCSLFRSFRQA	EXOC3L4	76	Q17RC7
FRRCLFLSFVSTDKD	LINC00242	31	Q5T6M2
LFRKLTAKDASCLFR	ALG13	231	Q9NP73
LKSRGLFDSFRRDCK	BOD1L2	46	Q8IYS8
DLESSICFSLFRRRR	FBXO10	91	Q9UK96
TLDRKFRRDSLFCPD	ACAP3	571	Q96P50
SACSRRQLRAFFRKG	ADAM33	386	Q9BZ11
VEEEKCFRRFTRSNS	DLGAP1	681	O14490
VGKTSFLRRFCEDRF	CRACR2A	556	Q9BSW2
EYFKRFCLDSARQTR	FAM193A	1231	P78312
DCVTFQLFKSFRRVR	RCAN2	41	Q14206
STTLFLAREAFRRAC	RFT1	56	Q96AA3
TRSFRLACDSRRVSF	IQCM	201	A0A1B0GVH7
QDSLFASRTLFKSRR	NUP205	1921	Q92621
ASRTLFKSRRLQDSF	NUP205	1926	Q92621
IASFHRTFRECERKS	ANKRD27	156	Q96NW4
RCIDASLREFSNFLK	ARHGAP10	81	A1A4S6
LRAQRDCTFLRISKS	PNPLA6	596	Q8IY17
FSESFERQLCFRTKR	LNP1	111	A1A4G5
CSDPERKRFRFNSES	HIRIP3	86	Q9BW71
LRDLRDAFSRVKTFF	IL10	41	P22301
FLRRKRDSFICSKQE	KIT	681	P10721
EKTFRTLCSRFRCLD	HARBI1	261	Q96MB7
TDDFDKRLLNCFARV	DNAH8	4121	Q96JB1
KSTRDFSVDRVRVCF	PEG10	106	Q86TG7
LTFRLSFCRSRKINS	OR5C1	166	Q8NGR4
DESCTFKISLRNFRS	IFNAR2	36	P48551
RPCFKALRERLSSFT	PTK6	431	Q13882
AATLRFLSKFNCSRE	GPRC6A	111	Q5T6X5
SLRYSRKENRFVSCD	GPR149	651	Q86SP6
LDTDRLFRCRFNTSK	NPAS4	141	Q8IUM7
LFRCRFNTSKSLRRQ	NPAS4	146	Q8IUM7
SIKDFRLDFENRCRG	DYNC2H1	451	Q8NCM8
ALRCFASLADRFTRR	HECTD1	206	Q9ULT8
RDVYKAARSCLTDRS	HEATR5A	176	Q86XA9
RDFLRCQLDKFISSA	CCDC106	86	Q9BWC9
KSSRRLENFCRDFEL	FARP1	656	Q9Y4F1
LLRALSSFREESRFC	GAN	16	Q9H2C0
QTCSIFRARKRASLD	POLQ	981	O75417
KLTCSAFRLQRALRF	GDF5-AS1	11	Q5U4N7
RRSLCAREFRKLGFS	ELMO3	336	Q96BJ8
FSNRELRRCFSTTLL	GPR85	341	P60893
CRKNRDKVLLFSFST	ERCC6L2	531	Q5T890
CEERFSLFKNRNRLS	CYLD	106	Q9NQC7
NRSCRETGSFLDLFR	SLC22A15	286	Q8IZD6
CRAETRETFLREKFE	SLFN13	646	Q68D06
RSFKEFLQSSLRALR	IL6	196	P05231
RISLFSCLKDRHDFR	IFNA6	46	P05013
LSDNFKRSFQRILCL	SSTR1	326	P30872
CTALAFNLRRKSEFL	TBC1D31	86	Q96DN5
LSKDFCAREFEALRS	NDUFAF8	46	A1L188
SDRNICRAETRKTFL	SLFN11	641	Q7Z7L1
CRAETRKTFLRENFE	SLFN11	646	Q7Z7L1
SYCGKRFTRSDELQR	SP1	661	P08047
LFCGKRFTRSDELQR	SP8	391	Q8IXZ3
RQLFCLARAFVRKTS	ABCC8	1486	Q09428
LFRALSDAFFTCRKN	ANGEL1	16	Q9UNK9
FASRSSLRCCRIRFT	CLN3	331	Q13286
RFSTQRFSLDKLDSA	TTLL8	431	A6PVC2
SSTRPLRDFCLRRDF	USP21	231	Q9UK80
DGRTFLSRCEFQRAK	SMOC2	56	Q9H3U7
RKRRFSSSDFSDLSN	SP100	446	P23497
DFKDCERRFSRSDQL	WT1	356	P19544
KRRRTIEDFNKFCSF	PHF23	26	Q9BUL5
RKFLSFRLERHSNIC	ZC2HC1C	396	Q53FD0
SECRKAFRERSSLIN	ZNF84	406	P51523
EFCKRTFSTQVALRR	ZIM2	331	Q9NZV7
RLRSKLALSLCRSDF	WFIKKN1	421	Q96NZ8
EKLTRRDFQCSSFRD	ZNF566	106	Q969W8
FRCDTCDKSFRQRSA	ZNF224	316	Q9NZL3
FSNCRSLFNDRKLVE	UGT1A7	121	Q9HAW7
RSTTRDRNKKAAACF	KCNC4	576	Q03721
RFRALCSRDRLLASF	JMJD8	76	Q96S16
FVSLLCKRFEEATRR	MYO1F	851	O00160
LSNERICQKRRFSDS	N4BP1	276	O75113