Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR51T1 OR1F2P GPR55 OR8B4 OR52K2 PTGDR OR10T2 OR10R2 GPR75	9.10e-05	884	43	9	GO:0004930
GeneOntologyMolecularFunction	voltage-gated chloride channel activity	CLCN6 CLCN7	2.46e-04	11	43	2	GO:0005247
GeneOntologyMolecularFunction	olfactory receptor activity	OR51T1 OR1F2P OR8B4 OR52K2 OR10T2 OR10R2	3.03e-04	431	43	6	GO:0004984
GeneOntologyMolecularFunction	voltage-gated monoatomic anion channel activity	CLCN6 CLCN7	6.04e-04	17	43	2	GO:0008308
GeneOntologyMolecularFunction	acetylcholine receptor regulator activity	SPDYE7P SPDYE16	1.54e-03	27	43	2	GO:0030548
GeneOntologyMolecularFunction	neurotransmitter receptor regulator activity	SPDYE7P SPDYE16	1.65e-03	28	43	2	GO:0099602
GeneOntologyMolecularFunction	magnesium ion binding	DXO CSNK1A1L ATP10A CSNK1A1	1.93e-03	247	43	4	GO:0000287
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR51T1 OR1F2P GPR55 OR8B4 OR52K2 PTGDR OR10T2 OR10R2 GPR75	2.03e-03	1353	43	9	GO:0004888
GeneOntologyMolecularFunction	tRNA methyltransferase activity	NSUN4 TYW3	2.43e-03	34	43	2	GO:0008175
GeneOntologyMolecularFunction	odorant binding	OR8B4 OR10T2 OR10R2	2.58e-03	127	43	3	GO:0005549
GeneOntologyMolecularFunction	antiporter activity	SLC44A2 CLCN6 CLCN7	3.26e-03	138	43	3	GO:0015297
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR51T1 OR1F2P GPR55 SCN11A OR8B4 OR52K2 PTGDR OR10T2 OR10R2 ADCY5 GPR75	6.21e-05	1395	41	11	GO:0007186
GeneOntologyBiologicalProcess	positive regulation of Rho protein signal transduction	GPR55 CSNK1A1L CSNK1A1	7.37e-05	41	41	3	GO:0035025
GeneOntologyBiologicalProcess	detection of stimulus	OR51T1 OR1F2P SCN11A TIMELESS OR8B4 OR52K2 OR10T2 OR10R2	7.44e-05	722	41	8	GO:0051606
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR51T1 OR1F2P SCN11A OR8B4 OR52K2 OR10T2 OR10R2	1.34e-04	582	41	7	GO:0050906
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR51T1 OR1F2P OR8B4 OR52K2 OR10T2 OR10R2	1.97e-04	432	41	6	GO:0050911
GeneOntologyBiologicalProcess	negative regulation of cytoplasmic pattern recognition receptor signaling pathway	ZDHHC18 CSNK1A1L CSNK1A1	2.08e-04	58	41	3	GO:0039532
GeneOntologyBiologicalProcess	sensory perception of smell	OR51T1 OR1F2P OR8B4 OR52K2 OR10T2 OR10R2	2.93e-04	465	41	6	GO:0007608
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR51T1 OR1F2P OR8B4 OR52K2 OR10T2 OR10R2	3.66e-04	485	41	6	GO:0050907
GeneOntologyCellularComponent	beta-catenin destruction complex	CSNK1A1L CSNK1A1	3.03e-04	13	42	2	GO:0030877
Domain	7tm_1	OR51T1 OR1F2P GPR55 OR8B4 OR52K2 PTGDR OR10T2 OR10R2 GPR75	8.18e-06	677	39	9	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR51T1 OR1F2P GPR55 OR8B4 OR52K2 PTGDR OR10T2 OR10R2 GPR75	8.99e-06	685	39	9	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR51T1 OR1F2P GPR55 OR8B4 OR52K2 PTGDR OR10T2 OR10R2 GPR75	9.64e-06	691	39	9	PS50262
Domain	GPCR_Rhodpsn	OR51T1 OR1F2P GPR55 OR8B4 OR52K2 PTGDR OR10T2 OR10R2 GPR75	9.76e-06	692	39	9	IPR000276
Domain	GPCR_Rhodpsn_7TM	OR51T1 GPR55 OR8B4 OR52K2 PTGDR OR10T2 OR10R2 GPR75	6.04e-05	670	39	8	IPR017452
Domain	Olfact_rcpt	OR51T1 OR1F2P OR8B4 OR52K2 OR10T2 OR10R2	1.51e-04	393	39	6	IPR000725
Domain	Cl-channel_core	CLCN6 CLCN7	1.52e-04	9	39	2	IPR014743
Domain	-	CLCN6 CLCN7	1.52e-04	9	39	2	1.10.3080.10
Domain	Voltage_CLC	CLCN6 CLCN7	1.52e-04	9	39	2	PF00654
Domain	Cl-channel_volt-gated	CLCN6 CLCN7	1.52e-04	9	39	2	IPR001807
Domain	CBS	CLCN6 CLCN7	5.01e-04	16	39	2	SM00116
Domain	CBS_dom	CLCN6 CLCN7	7.88e-04	20	39	2	IPR000644
Domain	CBS	CLCN6 CLCN7	7.88e-04	20	39	2	PF00571
Domain	CBS	CLCN6 CLCN7	7.88e-04	20	39	2	PS51371
Domain	ZINC_PROTEASE	ATP23 ZMPSTE24	1.78e-02	98	39	2	PS00142
Pathway	WP_INFLUENCE_OF_LAMINOPATHIES_ON_WNT_SIGNALING	CSNK1A1L ZMPSTE24 CSNK1A1	6.44e-05	37	30	3	M39817
Pathway	WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES	CSNK1A1L ZMPSTE24 CSNK1A1	2.35e-04	57	30	3	M39877
Pathway	REACTOME_ACTIVATION_OF_SMO	CSNK1A1L CSNK1A1	3.92e-04	14	30	2	MM15228
Pubmed	Tissue-specific distribution of mouse casein kinase I alpha mRNA.	CSNK1A1L CSNK1A1	1.49e-06	2	43	2	9522121
Pubmed	Casein kinase 1 alpha regulates chromosome congression and separation during mouse oocyte meiotic maturation and early embryo development.	CSNK1A1L CSNK1A1	1.49e-06	2	43	2	23690993
Pubmed	Drosophila glucome screening identifies Ck1alpha as a regulator of mammalian glucose metabolism.	CSNK1A1L CSNK1A1	1.49e-06	2	43	2	25994086
Pubmed	The exon-intron architecture of human chloride channel genes is not conserved.	CLCN6 CLCN7	1.49e-06	2	43	2	9565675
Pubmed	CSNK1A1/CK1α suppresses autoimmunity by restraining the CGAS-STING1 signaling.	CSNK1A1L CSNK1A1	1.49e-06	2	43	2	37723657
Pubmed	Casein Kinase 1α Regulates Testosterone Synthesis and Testis Development in Adult Mice.	CSNK1A1L CSNK1A1	1.49e-06	2	43	2	36929849
Pubmed	Class III β-Tubulin Expression Is of Value in Selecting nab -Paclitaxel and Gemcitabine as First-Line Therapy in Unresectable Pancreatic Cancer.	CSNK1A1L CSNK1A1	1.49e-06	2	43	2	35695793
Pubmed	Csnk1a1 inhibition modulates the inflammatory secretome and enhances response to radiotherapy in glioma.	CSNK1A1L CSNK1A1	1.49e-06	2	43	2	34216174
Pubmed	Casein Kinase 1α as a Novel Factor Affects Thyrotropin Synthesis via PKC/ERK/CREB Signaling.	CSNK1A1L CSNK1A1	1.49e-06	2	43	2	37108197
Pubmed	Systems biology approach identifies the kinase Csnk1a1 as a regulator of the DNA damage response in embryonic stem cells.	CSNK1A1L CSNK1A1	1.49e-06	2	43	2	23354688
Pubmed	Knockdown of Csnk1a1 results in preimplantation developmental arrest in mice.	CSNK1A1L CSNK1A1	1.49e-06	2	43	2	36542875
Pubmed	Exploring the role of casein kinase 1α splice variants across cancer cell lines.	CSNK1A1L CSNK1A1	1.49e-06	2	43	2	38852281
Pubmed	Complete genomic structure of the CLCN6 and CLCN7 putative chloride channel genes(1).	CLCN6 CLCN7	1.49e-06	2	43	2	10500249
Pubmed	ClC-6 and ClC-7 are two novel broadly expressed members of the CLC chloride channel family.	CLCN6 CLCN7	1.49e-06	2	43	2	8543009
Pubmed	Mammalian casein kinase 1alpha and its leishmanial ortholog regulate stability of IFNAR1 and type I interferon signaling.	CSNK1A1L CSNK1A1	4.48e-06	3	43	2	19805514
Pubmed	Distinct neuropathologic phenotypes after disrupting the chloride transport proteins ClC-6 or ClC-7/Ostm1.	CLCN6 CLCN7	4.48e-06	3	43	2	21107136
Pubmed	Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia.	CSNK1A1L CSNK1A1	4.48e-06	3	43	2	24616378
Pubmed	Role of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS.	CSNK1A1L CSNK1A1	4.48e-06	3	43	2	25242043
Pubmed	CK1α ablation in keratinocytes induces p53-dependent, sunburn-protective skin hyperpigmentation.	CSNK1A1L CSNK1A1	4.48e-06	3	43	2	28878021
Pubmed	Type I Interferons Control Proliferation and Function of the Intestinal Epithelium.	CSNK1A1L CSNK1A1	4.48e-06	3	43	2	26811327
Pubmed	Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors.	CSNK1A1L CSNK1A1	4.48e-06	3	43	2	28655862
Pubmed	Collaborative effect of Csnk1a1 haploinsufficiency and mutant p53 in Myc induction can promote leukemic transformation.	CSNK1A1L CSNK1A1	8.94e-06	4	43	2	38147624
Pubmed	Cx43 phosphorylation sites regulate pancreatic cancer metastasis.	CSNK1A1L CSNK1A1	8.94e-06	4	43	2	33603164
Pubmed	The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic.	CSNK1A1L CSNK1A1	8.94e-06	4	43	2	32728212
Pubmed	Regulation of p53-MDMX interaction by casein kinase 1 alpha.	CSNK1A1L CSNK1A1	8.94e-06	4	43	2	16024788
Pubmed	A CK1α Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma.	CSNK1A1L CSNK1A1	8.94e-06	4	43	2	30487124
Pubmed	Chloride and the endosomal-lysosomal pathway: emerging roles of CLC chloride transporters.	CLCN6 CLCN7	8.94e-06	4	43	2	17110406
Pubmed	FAM83D directs protein kinase CK1α to the mitotic spindle for proper spindle positioning.	CSNK1A1L CSNK1A1	8.94e-06	4	43	2	31338967
Pubmed	Rps14, Csnk1a1 and miRNA145/miRNA146a deficiency cooperate in the clinical phenotype and activation of the innate immune system in the 5q- syndrome.	CSNK1A1L CSNK1A1	1.49e-05	5	43	2	30651631
Pubmed	Crbn I391V is sufficient to confer in vivo sensitivity to thalidomide and its derivatives in mice.	CSNK1A1L CSNK1A1	1.49e-05	5	43	2	30064974
Pubmed	CK1α deficiency impairs mouse uterine adenogenesis by inducing epithelial cell apoptosis through GSK3β pathway and inhibiting Foxa2 expression through p53 pathway†.	CSNK1A1L CSNK1A1	1.49e-05	5	43	2	37944068
Pubmed	Glutaredoxin 1 protects lens epithelial cells from epithelial-mesenchymal transition by preventing casein kinase 1α S-glutathionylation during posterior capsular opacification.	CSNK1A1L CSNK1A1	1.49e-05	5	43	2	36989576
Pubmed	Phosphorylation of FADD by the kinase CK1α promotes KRASG12D-induced lung cancer.	CSNK1A1L CSNK1A1	1.49e-05	5	43	2	25628462
Pubmed	A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism.	CSNK1A1L CSNK1A1	1.49e-05	5	43	2	23890787
Pubmed	CKIα ablation highlights a critical role for p53 in invasiveness control.	CSNK1A1L CSNK1A1	1.49e-05	5	43	2	21331045
Pubmed	Protein kinase CK1alpha regulates mRNA binding by heterogeneous nuclear ribonucleoprotein C in response to physiologic levels of hydrogen peroxide.	CSNK1A1L CSNK1A1	2.23e-05	6	43	2	15687492
Pubmed	Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways.	CSNK1A1L CSNK1A1	2.23e-05	6	43	2	11884395
Pubmed	Casein kinase 1alpha governs antigen-receptor-induced NF-kappaB activation and human lymphoma cell survival.	CSNK1A1L CSNK1A1	2.23e-05	6	43	2	19118383
Pubmed	Physiological role for casein kinase 1 in glutamatergic synaptic transmission.	CSNK1A1L CSNK1A1	2.23e-05	6	43	2	16014721
Pubmed	MDMX inhibits casein kinase 1α activity and stimulates Wnt signaling.	CSNK1A1L CSNK1A1	2.23e-05	6	43	2	32511789
Pubmed	MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism.	CSNK1A1L CSNK1A1	2.23e-05	6	43	2	33667384
Pubmed	The synovial sarcoma SYT-SSX2 oncogene remodels the cytoskeleton through activation of the ephrin pathway.	CSNK1A1L CSNK1A1	3.12e-05	7	43	2	17686994
Pubmed	Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5.	CSNK1A1L CSNK1A1	3.12e-05	7	43	2	25644602
Pubmed	NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly.	CSNK1A1L CSNK1A1	3.12e-05	7	43	2	34615873
Pubmed	Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism.	CSNK1A1L CSNK1A1	4.16e-05	8	43	2	17244647
Pubmed	The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1.	CSNK1A1L CSNK1A1	4.16e-05	8	43	2	21930935
Pubmed	Casein kinase 1 delta (CK1delta) interacts with the SNARE associated protein snapin.	CSNK1A1L CSNK1A1	4.16e-05	8	43	2	17101137
Pubmed	The human olfactory receptor gene family.	OR51T1 OR1F2P OR8B4 OR52K2 OR10T2 OR10R2	5.15e-05	541	43	6	14983052
Pubmed	Changing expression of chloride channels during preimplantation mouse development.	CLCN6 CLCN7	5.35e-05	9	43	2	23115349
Pubmed	Effects of Fam83h truncation mutation on enamel developmental defects in male C57/BL6J mice.	CSNK1A1L CSNK1A1	5.35e-05	9	43	2	36272714
Pubmed	Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta.	CSNK1A1L CSNK1A1	5.35e-05	9	43	2	9601641
Pubmed	Murine fertility and spermatogenesis are independent of the testis-specific Spdye4a gene.	SPDYE7P SPDYE16	5.35e-05	9	43	2	36272447
Pubmed	Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7.	CSNK1A1L CSNK1A1	6.68e-05	10	43	2	25500533
Pubmed	Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex.	CSNK1A1L CSNK1A1	8.15e-05	11	43	2	21709260
Pubmed	Peli1 Modulates the Subcellular Localization and Activity of Mdmx.	CSNK1A1L CSNK1A1	9.78e-05	12	43	2	29523541
Pubmed	Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins.	SPDYE7P SPDYE16	1.15e-04	13	43	2	15611625
Pubmed	Casein kinase 1α mediates estradiol secretion via CYP19A1 expression in mouse ovarian granulosa cells.	CSNK1A1L CSNK1A1	1.35e-04	14	43	2	39183304
Pubmed	Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction.	CSNK1A1L CSNK1A1	1.55e-04	15	43	2	18827223
Pubmed	The COP9 signalosome mediates beta-catenin degradation by deneddylation and blocks adenomatous polyposis coli destruction via USP15.	CSNK1A1L CSNK1A1	1.77e-04	16	43	2	19576224
Pubmed	Characterization of a new family of cyclin-dependent kinase activators.	SPDYE7P SPDYE16	2.01e-04	17	43	2	15574121
Pubmed	Integral and associated lysosomal membrane proteins.	SLC44A2 CLCN6 CLCN7	5.15e-04	126	43	3	17897319
Pubmed	Casein kinase 1α is required to maintain murine hypothalamic pro-opiomelanocortin expression.	CSNK1A1L CSNK1A1	6.79e-04	31	43	2	37168577
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	SCN11A CLCN6 CLCN7	6.86e-04	139	43	3	16985003
Pubmed	An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance.	CSNK1A1L CSNK1A1	7.69e-04	33	43	2	30783098
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR51T1 OR1F2P OR8B4 OR52K2	8.20e-04	340	43	4	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR51T1 OR1F2P OR8B4 OR52K2	8.20e-04	340	43	4	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR51T1 OR1F2P OR8B4 OR52K2	8.47e-04	343	43	4	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR51T1 OR1F2P OR8B4 OR52K2	8.75e-04	346	43	4	14611657
Pubmed	Ion channel expression in the developing enteric nervous system.	CLCN6 CLCN7	9.67e-04	37	43	2	25798587
Cytoband	1p34	NSUN4 ZMPSTE24	4.18e-04	32	43	2	1p34
Cytoband	1q23.1	OR10T2 OR10R2	8.64e-04	46	43	2	1q23.1
GeneFamily	Chloride voltage-gated channels	CLCN6 CLCN7	1.11e-04	10	29	2	302
Disease	syndromic X-linked intellectual disability Najm type (implicated_via_orthology)	CSNK1A1L CSNK1A1	3.03e-05	7	36	2	DOID:0060807 (implicated_via_orthology)
Disease	platelet component distribution width	SLC44A2 SCN11A ATP23 BRF1 ADCY5 RTTN	2.78e-04	755	36	6	EFO_0007984
Disease	ocular hypertension, response to triamcinolone acetonide	TIMELESS CFAP61	1.64e-03	49	36	2	EFO_0006954, EFO_1001069
Disease	HOMA-B	ATP10A ADCY5	2.06e-03	55	36	2	EFO_0004469
Disease	polychlorinated biphenyls measurement	CYP2B6 ADCY5	2.87e-03	65	36	2	EFO_0007042
Disease	serum alanine aminotransferase measurement, response to combination chemotherapy	RNF213 ZDHHC18	3.41e-03	71	36	2	EFO_0004735, EFO_0007965

Protein segments in the cluster

Peptide	Gene	Start	Entry
ARSLDFMNFVFSLFS	CFAP61	401	Q8NHU2
FMNFVFSLFSDKNFC	CFAP61	406	Q8NHU2
LFLFFTTILQNFSMA	CYP2B6	446	P20813
SFFMLFSSNFVLNRC	CARNMT1	231	Q8N4J0
FLAAFVNMFTCNSRD	ADCY5	846	O95622
FQFFCGFSASTMIDQ	ATP10A	1106	O60312
DNSLCQAFAFFMSFF	PTGDR	101	Q13258
CMTQLFFFCFFVNSE	OR8B4	96	Q96RC9
FFSSFFTSNQKCQLR	ATP23	41	Q9Y6H3
MEVFNANIFSTSCLF	KCTD21	141	Q4G0X4
LQSHFVLFFFSMCQS	MIR17HG	31	Q75NE6
RIFFASMISTFTLNF	CLCN7	326	P51798
AREISFKACFIQMFF	OR51T1	91	Q8NGJ9
FRMFNCSFQFSLENI	PNPLA1	211	Q8N8W4
SLEDLFNFCSRRFTM	CSNK1A1L	96	Q8N752
ISFFLQLSMCFSNVN	GPR55	266	Q9Y2T6
VCMNFCAAFLSFAQS	DXO	326	O77932
RTNFDFMILNLSFCD	GPR75	76	O95800
RVFMDTFCFFSSCQV	NSUN4	346	Q96CB9
FFLSNMSFVDNCFST	OR1F2P	61	Q96R84
KTISFMACATQLFFF	OR10T2	91	Q8NGX3
LFCSMSATFTLNFFR	CLCN6	281	P51797
RRMFSSLFQFSNCSQ	CCDC3	151	Q9BQI4
FNNFISCLVRLDAMF	CAPNS2	206	Q96L46
SSSAFTFTCNKFFRR	FBXO40	471	Q9UH90
LLFQFGMNASSSRFF	LAMP1	286	P11279
TNFCTSARNAFFLLM	SLC44A2	571	Q8IWA5
ISQMNSFLCFFLFAV	ZMPSTE24	351	O75844
TISFNCCALQMFFFL	OR10R2	111	Q8NGX6
FFACLAQMFFLHSFS	OR52K2	96	Q8NGK3
RCMFDLNFSAFDRNS	RTTN	1501	Q86VV8
KFSNEVFRFASACMN	SAMD9L	216	Q8IVG5
LVLSAQSCFFRSMFT	KBTBD4	61	Q9NVX7
QSCFFRSMFTSNLKE	KBTBD4	66	Q9NVX7
SLEDLFNFCSRRFTM	CSNK1A1	96	P48729
FRQMCNSFFVDLVST	RNF213	4061	Q63HN8
ALAFFMAFNRAASFR	TIMELESS	381	Q9UNS1
IALFQKLRFQFFCSM	SPDYE16	266	A6NNV3
IALFQKLRFQFFCSM	SPDYE18	306	P0DV79
QKLRFQFFCSMSCRA	SPDYE7P	166	Q495Y7
CLDTAFNFFKMAVSR	BRF1	106	Q92994
IFNFKTFASSMLCLF	SCN11A	1531	Q9UI33
LFQKLRFQFFCSMSG	nan	246	A6NJR5
VKNFLMFFSFCRRQQ	UGT3A2	201	Q3SY77
LFFFVMSCLLQTSFT	ZDHHC18	131	Q9NUE0
FLNMRDQFFTTSSCA	TYW3	36	Q6IPR3