Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	PCMTD2 PCMTD1	4.17e-05	3	75	2	GO:0004719
GeneOntologyMolecularFunction	histone H3K27me2/H3K27me3 demethylase activity	KDM6A UTY	1.38e-04	5	75	2	GO:0071558
GeneOntologyMolecularFunction	carboxyl-O-methyltransferase activity	PCMTD2 PCMTD1	2.89e-04	7	75	2	GO:0010340
GeneOntologyMolecularFunction	protein carboxyl O-methyltransferase activity	PCMTD2 PCMTD1	2.89e-04	7	75	2	GO:0051998
MousePheno	increased diameter of long bones	HOXA11 ACP5 CHST11 TNFRSF11A	1.33e-05	36	57	4	MP:0008151
Domain	PCMT	PCMTD2 PCMTD1	4.51e-05	3	73	2	IPR000682
Domain	PCMT	PCMTD2 PCMTD1	4.51e-05	3	73	2	PS01279
Domain	TPR-contain_dom	SH3TC2 VPS13A CDC27 KDM6A UTY	3.03e-04	150	73	5	IPR013026
Domain	PAN	PLG KLKB1	3.12e-04	7	73	2	PS50948
Domain	Pan_app	PLG KLKB1	3.12e-04	7	73	2	IPR003609
Domain	PAN_1	PLG KLKB1	3.12e-04	7	73	2	PF00024
Domain	TPR_1	SH3TC2 CDC27 KDM6A UTY	4.26e-04	90	73	4	PF00515
Domain	TPR_1	SH3TC2 CDC27 KDM6A UTY	4.26e-04	90	73	4	IPR001440
Domain	TPR_REGION	SH3TC2 VPS13A CDC27 KDM6A UTY	4.69e-04	165	73	5	PS50293
Domain	TPR	SH3TC2 VPS13A CDC27 KDM6A UTY	4.69e-04	165	73	5	PS50005
Pubmed	An H-YDb epitope is encoded by a novel mouse Y chromosome gene.	KDM6A UTY	4.71e-06	2	76	2	8944031
Pubmed	Sex-specific differences in expression of histone demethylases Utx and Uty in mouse brain and neurons.	KDM6A UTY	4.71e-06	2	76	2	18434530
Pubmed	Target sequencing and CRISPR/Cas editing reveal simultaneous loss of UTX and UTY in urothelial bladder cancer.	KDM6A UTY	4.71e-06	2	76	2	27533081
Pubmed	Positive and negative selection on mammalian Y chromosomes.	KDM6A UTY	4.71e-06	2	76	2	15758204
Pubmed	Lysine demethylases KDM6A and UTY: The X and Y of histone demethylation.	KDM6A UTY	4.71e-06	2	76	2	31097364
Pubmed	Leveraging the Mendelian disorders of the epigenetic machinery to systematically map functional epigenetic variation.	CREBBP KDM6A	1.41e-05	3	76	2	34463256
Pubmed	The UTX gene escapes X inactivation in mice and humans.	KDM6A UTY	1.41e-05	3	76	2	9499428
Pubmed	Inhibitory properties of a novel human Kunitz-type protease inhibitor homologous to tissue factor pathway inhibitor.	PLG KLKB1	2.82e-05	4	76	2	8555184
Pubmed	Spindle assembly checkpoint protein Cdc20 transcriptionally activates expression of ubiquitin carrier protein UbcH10.	CDC27 CREBBP	2.82e-05	4	76	2	21454660
Pubmed	Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms.	KDM6A UTY	2.82e-05	4	76	2	9854018
Pubmed	CREB binding protein is required for both short-term and long-term memory formation.	ARNT CREBBP	2.82e-05	4	76	2	20881124
Pubmed	X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis.	KDM6A UTY	2.82e-05	4	76	2	32732223
Pubmed	Deletion and expression analysis of AZFa genes on the human Y chromosome revealed a major role for DBY in male infertility.	KDM6A UTY	2.82e-05	4	76	2	10767340
Pubmed	Integrin-Linked Kinase Regulates Bone Formation by Controlling Cytoskeletal Organization and Modulating BMP and Wnt Signaling in Osteoprogenitors.	ILK TNFRSF11A	4.69e-05	5	76	2	28574598
Pubmed	Calmodulin-dependent protein kinase II potentiates transcriptional activation through activating transcription factor 1 but not cAMP response element-binding protein.	CAMK2G CREBBP	4.69e-05	5	76	2	8663317
Pubmed	Cell cycle-dependent expression of centrosomal ninein-like protein in human cells is regulated by the anaphase-promoting complex.	NINL CDC27	4.69e-05	5	76	2	17403670
Pubmed	Double disruption of α2A- and α2C-adrenoceptors results in sympathetic hyperactivity and high-bone-mass phenotype.	ACP5 TNFRSF11A	4.69e-05	5	76	2	20814988
Pubmed	Cathepsin X cleaves the C-terminal dipeptide of alpha- and gamma-enolase and impairs survival and neuritogenesis of neuronal cells.	PLG CTSZ	7.03e-05	6	76	2	19433310
Pubmed	Role of the captured retroviral envelope syncytin-B gene in the fusion of osteoclast and giant cell precursors and in bone resorption, analyzed ex vivo and in vivo in syncytin-B knockout mice.	ACP5 TNFRSF11A	7.03e-05	6	76	2	31360740
Pubmed	Quantitative trait loci associated with blood pressure of metabolic syndrome in the progeny of NZO/HILtJxC3H/HeJ intercrosses.	PTPN14 KLKB1	7.03e-05	6	76	2	17641813
Pubmed	Role of CBP in regulating HIF-1-mediated activation of transcription.	ARNT CREBBP	7.03e-05	6	76	2	15615775
Pubmed	UTX Affects Neural Stem Cell Proliferation and Differentiation through PTEN Signaling.	KDM6A UTY	9.83e-05	7	76	2	29551674
Pubmed	Maternal epigenetic factors in embryonic and postnatal development.	MLLT10 KDM6A	9.83e-05	7	76	2	36906847
Pubmed	UTX deficiency in neural stem/progenitor cells results in impaired neural development, fetal ventriculomegaly, and postnatal death.	KDM6A UTY	1.31e-04	8	76	2	36412518
Pubmed	UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development.	KDM6A UTY	1.68e-04	9	76	2	23028370
Pubmed	UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity.	KDM6A UTY	1.68e-04	9	76	2	22949634
Pubmed	Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp).	IGSF8 ARNT MTMR4	1.72e-04	49	76	3	10051400
Pubmed	Novel gene expression patterns along the proximo-distal axis of the mouse embryo before gastrulation.	CUBN CTSZ	2.10e-04	10	76	2	17302988
Pubmed	Deregulation of Rb-E2F1 axis causes chromosomal instability by engaging the transactivation function of Cdc20-anaphase-promoting complex/cyclosome.	CDC27 CREBBP	2.56e-04	11	76	2	25368385
Pubmed	Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides.	CPN2 PZP KLKB1	2.99e-04	59	76	3	17330941
Pubmed	LncRNA-HIT Functions as an Epigenetic Regulator of Chondrogenesis through Its Recruitment of p100/CBP Complexes.	HOXA11 CREBBP	3.07e-04	12	76	2	26633036
Pubmed	Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches.	KDM6A UTY	3.62e-04	13	76	2	14660691
Pubmed	Osteoclast differentiation and dynamic mRNA expression during mice embryonic palatal bone development.	ACP5 TNFRSF11A	3.62e-04	13	76	2	37704707
Pubmed	UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program.	KDM6A UTY	3.62e-04	13	76	2	22192413
Pubmed	Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.	NELL1 TSEN34 CHST11 GREB1 HEPHL1 PZP KLKB1 CREBBP	4.03e-04	814	76	8	23251661
Pubmed	Th2 and eosinophil responses suppress inflammatory arthritis.	ACP5 TNFRSF11A	4.22e-04	14	76	2	27273006
Pubmed	Mediator of DNA damage checkpoint 1 (MDC1) regulates mitotic progression.	CDC27 CREBBP	4.22e-04	14	76	2	19826003
Pubmed	SIRT3 regulates cancer cell proliferation through deacetylation of PYCR1 in proline metabolism.	PDHB CREBBP	4.86e-04	15	76	2	31108370
Pubmed	Efficient and fast targeted production of murine models based on ENU mutagenesis.	GREB1 MFRP	4.86e-04	15	76	2	16075367
Pubmed	Quantitative trait loci analysis reveals candidate genes implicated in regulating functional deficit and CNS vascular permeability in CD8 T cell-initiated blood-brain barrier disruption.	AFDN PLG	4.86e-04	15	76	2	24090483
Pubmed	KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis.	KDM6A UTY	5.54e-04	16	76	2	35212626
Pubmed	Proteome-wide characterization of N-glycosylation events by diagonal chromatography.	CPN2 PZP KLKB1	6.53e-04	77	76	3	16944957
Pubmed	A global genomic transcriptional code associated with CNS-expressed genes.	ZNF462 PTPN14 GALNT17 GPATCH2 PCMTD1	6.73e-04	318	76	5	16919269
Pubmed	Sex differences in sex chromosome gene expression in mouse brain.	KDM6A UTY	7.05e-04	18	76	2	12023983
Pubmed	Mfrp, a gene encoding a frizzled related protein, is mutated in the mouse retinal degeneration 6.	NLRX1 MFRP	7.05e-04	18	76	2	12140190
Pubmed	The HOX homeodomain proteins block CBP histone acetyltransferase activity.	HOXA11 CREBBP	7.05e-04	18	76	2	11585930
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	TRAF7 ILK PDHB CAMK2G NLRX1 GPATCH2 CDC27 CREBBP	8.36e-04	910	76	8	36736316
Pubmed	Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis.	KDM6A UTY	8.73e-04	20	76	2	19047629
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	ZNF462 HOXA11 ARNT BAZ2A AFDN MLLT10 CREBBP	9.19e-04	709	76	7	22988430
Pubmed	A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes.	PTPN14 NADK AFDN	9.32e-04	87	76	3	17979178
Pubmed	The DNA sequence and comparative analysis of human chromosome 20.	ANKEF1 NINL PCMTD2 LRRN4 CTSZ ACTL10	9.51e-04	517	76	6	11780052
Pubmed	A gain-of-function mutation in Tnni2 impeded bone development through increasing Hif3a expression in DA2B mice.	ARNT ACP5	9.63e-04	21	76	2	25340332
Pubmed	Interaction network of human early embryonic transcription factors.	ZNF462 ARNT L3MBTL2 CREBBP KDM6A	1.05e-03	351	76	5	38297188
Pubmed	Non-EST-based prediction of novel alternatively spliced cassette exons with cell signaling function in Caenorhabditis elegans and human.	CRYGN UTY	1.26e-03	24	76	2	17452356
Pubmed	Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding.	GALNT17 CUBN	1.26e-03	24	76	2	31740596
Pubmed	Interaction of Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) and Vav3 in the Receptor Activator of Nuclear Factor κB (RANK) Signaling Complex Enhances Osteoclastogenesis.	TNFRSF11A CPN2	1.26e-03	24	76	2	27507811
Pubmed	Functional coherence of the human Y chromosome.	KDM6A UTY	1.37e-03	25	76	2	9381176
Pubmed	β-catenin activity in late hypertrophic chondrocytes locally orchestrates osteoblastogenesis and osteoclastogenesis.	ACP5 TNFRSF11A	1.60e-03	27	76	2	27621061
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	TRAF7 ARNT PTPN14 ZNF507 TSEN34 CREBBP	1.83e-03	588	76	6	38580884
Pubmed	Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2.	ARNT PLG	1.84e-03	29	76	2	16966370
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZNF462 ARNT BAZ2A ZNF507 MLLT10 KDM6A UTY	1.94e-03	808	76	7	20412781
Pubmed	Inherited genetic variant predisposes to aggressive but not indolent prostate cancer.	ZNF462 CHST11	1.97e-03	30	76	2	20080650
Pubmed	Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer.	LDHD CAMK2G UTY	2.13e-03	116	76	3	30652415
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	SH3TC2 CDC27 KDM6A UTY	3.58e-04	115	53	4	769
GeneFamily	Ankyrin repeat domain containing	ILK TRPA1 ANKUB1 ANKEF1 ANKRD10	7.01e-04	242	53	5	403
GeneFamily	Kallikreins	KLK9 KLKB1	9.85e-04	16	53	2	616
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM6A UTY	2.23e-03	24	53	2	485
Coexpression	MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN	ARNT MTMR4 ACP5 SEPTIN1 PELI1 PLG MLLT10 CUBN CDC27	1.72e-05	519	75	9	M3395
Coexpression	MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN	ARNT MTMR4 ACP5 SEPTIN1 PELI1 PLG MLLT10 CUBN CDC27	2.45e-05	543	75	9	MM997
Disease	Kabuki syndrome (implicated_via_orthology)	KDM6A UTY	1.81e-05	3	73	2	DOID:0060473 (implicated_via_orthology)
Disease	tyrosine-protein kinase JAK2 measurement	CPN2 KLKB1	1.67e-04	8	73	2	EFO_0020825
Disease	IGFBP-3 measurement	MFHAS1 GREB1 CREBBP	3.29e-04	54	73	3	EFO_0004626
Disease	hepcidin:transferrin saturation ratio	NELL1 PDHB	6.21e-04	15	73	2	EFO_0007902
Disease	cardiac troponin I measurement	NELL1 GREB1 PZP KLKB1	9.66e-04	176	73	4	EFO_0010071
Disease	Meningioma	TRAF7 MLLT10	1.00e-03	19	73	2	C0025286
Disease	Craniosynostosis	ZNF462 NELL1	1.11e-03	20	73	2	C0010278
Disease	apolipoprotein L1 measurement	CPN2 PKD1L3	1.75e-03	25	73	2	EFO_0021854
Disease	Colorectal Carcinoma	NELL1 ARNT VPS13A CUBN PZP KDM6A PRIMA1	1.75e-03	702	73	7	C0009402

Protein segments in the cluster

Peptide	Gene	Start	Entry
CSHYWGAIIRQQLGH	AFDN	811	P55196
PHFVVVHCTGYIKAW	ARNT	301	P27540
VCHATPIYAGHSWHQ	ACTL10	26	Q5JWF8
ALHGNPWQCDCHLAY	CPN2	391	P22792
AHIAAFGGHPQCLVW	ANKRD10	96	Q9NXR5
RNQHIPQYCGSCWAH	CTSZ	81	Q9UBR2
IHNIQPSDNGQYWCH	BTNL2	111	Q9UIR0
QHTHINGVTCWGIDY	ADAM21	581	Q9UKJ8
HLHHPSVAYDCLWNY	BAZ2A	81	Q9UIF9
HQICVLHYDIIWPSG	CREBBP	1291	Q92793
NFLWTPLHFACHAGQ	ANKEF1	556	Q9NU02
TVHPNLCFHYSWVAE	PZP	421	P20742
YPHQLLCTWHISVPA	MFRP	321	Q9BY79
AQHSQCFAAWYGHCP	PDHB	156	P11177
VYCLPIGHWIEATGH	EPM2A	121	O95278
AWALSNVAAGPCHHI	KPNA7	346	A9QM74
LQCQHHPAWYGDTLK	KIAA0100	1606	Q14667
VWLHNCHTGNSYPAN	LOXL4	726	Q96JB6
HWPASCSNGVDLYHE	GREB1	836	Q4ZG55
QEWPGLHYTVHILCS	MFHAS1	971	Q9Y4C4
HDFWCNLGTVDVHPI	L3MBTL2	256	Q969R5
YICAVQLDHGHAAAW	KDM6A	341	O15550
CHGDETWSYNHPIRG	NADK	26	O95544
WKHGNIHLSAPCIYS	PCMTD1	56	Q96MG8
WKHGNIHLSAPCIYS	PCMTD2	56	Q9NV79
TKWHPRGNLAHCYSA	HOXA11	71	P31270
HHQIAAACFLPSYCW	NLRX1	361	Q86UT6
SIHVESGAWVCFNHP	CRYGN	41	Q8WXF5
HNHSRCVNLPGWYHC	NELL1	561	Q92832
PVCHVRALHLWTAVY	MTMR4	556	Q9NYA4
KYTNHPPALWVHNTC	OXNAD1	131	Q96HP4
HLAGCQEQAAWYHTL	PAQR8	236	Q8TEZ7
VYPHGINCTWHILVQ	CUBN	951	O60494
AALYALCWGPHHALI	GALR3	241	O60755
VYHCAPSAWVQHADY	IGSF8	541	Q969P0
EIPHHTAWYSPCVSL	LDHD	216	Q86WU2
VNEHGNVPLHYACFW	ILK	96	Q13418
NHTAILYPCHGWGPQ	GALNT17	486	Q6IS24
PADANCLTWVYHSHI	HEPHL1	176	Q6MZM0
VGCPYVRFHTEVHWH	MAN2C1	791	Q9NTJ4
ENKLCHWAYPGHISD	KLK9	171	Q9UKQ9
HQWVLTAAHCFDGLP	KLKB1	426	P03952
YNVHHPWETGHCLSE	GPATCH2	76	Q9NW75
LPSHHYNTGWVLCQI	CDC27	491	P30260
KWLNVHYHCSGAPAA	CAMK2G	541	Q13555
ALVHWCAPNSVVHGY	LRRN4	596	Q8WUT4
DEKQPWVYLNCGHVH	PELI1	301	Q96FA3
NVSRWFCHIQHYPGI	EEF1E1	141	O43324
TFWVPLCGHRQVDHF	OR2J3	166	O76001
WHGRTNDEPAHYCSI	UTY	1266	O14607
QWVVSAGHCYKPHIQ	PRSS3P2	56	Q8NHM4
CALHPLWGFVQVTHG	PRIMA1	21	Q86XR5
EWHYIATQGPLPHTC	PTPN14	976	Q15678
WARVVPENHHHFCCY	PKD1L3	1061	Q7Z443
NPEACITYHEHWLAL	SH3TC2	976	Q8TF17
KAWSHYQVPEESGCH	NINL	281	Q9Y2I6
CQAWDSQSPHAHGYI	PLG	206	P00747
KAFPVWEGGVCHHVY	SNED1	1361	Q8TER0
DYVAPGHCWLNVHTN	ADGRD2	786	Q7Z7M1
DNGGWAHVVCALYIP	MLLT10	96	P55197
AVGVHPYRAWCHEAL	ANKUB1	221	A6NFN9
NEHWQTVYSLCHPCH	CHST11	256	Q9NPF2
RYSWGTVEVENPHHC	SEPTIN1	251	Q8WYJ6
WDVSGGLCQHLIFPH	WDR90	1191	Q96KV7
IPAHLQWQCGAIAVY	TRPA1	826	O75762
WAYAIHGVLEVNVCP	VPS13A	331	Q96RL7
PLRFHAHYIAQCWAP	TSEN34	251	Q9BSV6
KSIPHNCYEIGHTWH	TMEM135	6	Q86UB9
NCYEIGHTWHPSCRV	TMEM135	11	Q86UB9
TFVGHQGPVWCLCVY	TRAF7	391	Q6Q0C0
YPVWSIAEHGPTHCL	ACP5	206	P13686
VLVRHHGAWGYVCNQ	SCART1	41	Q4G0T1
SHLWEAYCRATAPHP	SNX19	186	Q92543
HAWKHAGEVDCSYPI	ZNF507	266	Q8TCN5
WCIYSHTEPNGLLLH	ZNF462	1316	Q96JM2
AGAAFVHACEWNPHA	TRMT12	256	Q53H54
HWSVHTGARPYECIA	ZNF772	396	Q68DY9
YLQKEVDSGHCPHWA	TNFRSF11A	421	Q9Y6Q6