Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	hippocampal mossy fiber	MAPK8IP1 MAP1B	1.08e-04	7	48	2	GO:0097457
GeneOntologyCellularComponent	dense core granule	DMXL2 BACE2 P2RX2	2.89e-04	56	48	3	GO:0031045
GeneOntologyCellularComponent	presynaptic active zone	CTNNA2 TENM3 TRIO P2RX2	3.07e-04	141	48	4	GO:0048786
MousePheno	abnormal heart atrium morphology	PCSK5 JARID2 JUP CMYA5 IFT172 RYR1 MAP3K3	2.58e-06	232	38	7	MP:0003105
Domain	Arrestin-like_N	ARR3 ARRDC1	2.52e-04	10	45	2	IPR011021
Domain	Arrestin_C-like	ARR3 ARRDC1	2.52e-04	10	45	2	IPR011022
Domain	Arrestin_C	ARR3 ARRDC1	2.52e-04	10	45	2	PF02752
Domain	Arrestin_N	ARR3 ARRDC1	2.52e-04	10	45	2	PF00339
Domain	Arrestin_C	ARR3 ARRDC1	2.52e-04	10	45	2	SM01017
Domain	PTPc	PTPN1 PTPRM	3.39e-03	36	45	2	SM00194
Domain	TYR_PHOSPHATASE_PTP	PTPN1 PTPRM	3.97e-03	39	45	2	PS50055
Domain	PTPase_domain	PTPN1 PTPRM	4.38e-03	41	45	2	IPR000242
Domain	Y_phosphatase	PTPN1 PTPRM	4.38e-03	41	45	2	PF00102
Domain	WD40_repeat_dom	DMXL2 TENM3 UTP15 IFT172	5.59e-03	297	45	4	IPR017986
Domain	PTPc_motif	PTPN1 PTPRM	8.90e-03	59	45	2	SM00404
Domain	Tyr_Pase_cat	PTPN1 PTPRM	8.90e-03	59	45	2	IPR003595
Pubmed	Improved metabolic phenotype of hypothalamic PTP1B-deficiency is dependent upon the leptin receptor.	PTPN1 LEPR	1.87e-06	2	48	2	24749060
Pubmed	Deficiency of PTP1B in leptin receptor-expressing neurons leads to decreased body weight and adiposity in mice.	PTPN1 LEPR	1.87e-06	2	48	2	22802463
Pubmed	ER stress increases expression of intracellular calcium channel RyR1 to modify Ca2+ homeostasis in pancreatic beta cells.	LEPR RYR1	1.87e-06	2	48	2	37468098
Pubmed	Increased proteolytic processing of protein tyrosine phosphatase mu in confluent vascular endothelial cells: the role of PC5, a member of the subtilisin family.	PCSK5 PTPRM	1.87e-06	2	48	2	8620001
Pubmed	Severe energy deficit upregulates leptin receptors, leptin signaling, and PTP1B in human skeletal muscle.	PTPN1 LEPR	1.87e-06	2	48	2	28729389
Pubmed	S-adenosylmethionine levels regulate the schwann cell DNA methylome.	GNMT LEPR	1.87e-06	2	48	2	24607226
Pubmed	Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity.	PTPN1 LEPR	1.87e-06	2	48	2	23512805
Pubmed	Tyrosine phosphatase 1B and leptin receptor genes and their interaction in type 2 diabetes.	PTPN1 LEPR	1.87e-06	2	48	2	15189365
Pubmed	Deletion of protein tyrosine phosphatase 1b improves peripheral insulin resistance and vascular function in obese, leptin-resistant mice via reduced oxidant tone.	PTPN1 LEPR	1.87e-06	2	48	2	19797171
Pubmed	Cholesteryl ester transfer protein expression prevents diet-induced atherosclerotic lesions in male db/db mice.	CETP LEPR	1.87e-06	2	48	2	12791674
Pubmed	Increasing peripheral insulin sensitivity by protein tyrosine phosphatase 1B deletion improves control of blood pressure in obesity.	PTPN1 LEPR	5.59e-06	3	48	2	23045458
Pubmed	HIV Protease Inhibitor Ritonavir Impairs Endothelial Function Via Reduction in Adipose Mass and Endothelial Leptin Receptor-Dependent Increases in NADPH Oxidase 1 (Nox1), C-C Chemokine Receptor Type 5 (CCR5), and Inflammation.	PTPN1 LEPR	5.59e-06	3	48	2	33003981
Pubmed	Protein-tyrosine phosphatase 1B (PTP1B) is a novel regulator of central brain-derived neurotrophic factor and tropomyosin receptor kinase B (TrkB) signaling.	PTPN1 LEPR	5.59e-06	3	48	2	25288805
Pubmed	Overexpression of forebrain PTP1B leads to synaptic and cognitive impairments in obesity.	PTPN1 LEPR	5.59e-06	3	48	2	38336024
Pubmed	Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1.	PTPN1 LEPR	1.12e-05	4	48	2	30158241
Pubmed	Distinct cadherin-catenin complexes in Ca(2+)-dependent cell-cell adhesion.	JUP CTNNA2	1.12e-05	4	48	2	7982500
Pubmed	The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species.	JUP CTNNA2	1.86e-05	5	48	2	2788574
Pubmed	Bace2 is a β cell-enriched protease that regulates pancreatic β cell function and mass.	BACE2 LEPR	1.86e-05	5	48	2	21907142
Pubmed	Distinct roles of c-Jun N-terminal kinase isoforms in neurite initiation and elongation during axonal regeneration.	MAPK8IP1 MAP1B	1.86e-05	5	48	2	20534829
Pubmed	Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule.	JUP CTNNA2	1.86e-05	5	48	2	2349235
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	JUP RAPGEF6 TENM3 TRIO PTPRM RAB11FIP2	2.42e-05	421	48	6	36976175
Pubmed	Soy-isoflavone-enriched foods and markers of lipid and glucose metabolism in postmenopausal women: interactions with genotype and equol production.	CETP LEPR	2.79e-05	6	48	2	16522905
Pubmed	Akt2 (Protein Kinase B Beta) Stabilizes ATP7A, a Copper Transporter for Extracellular Superoxide Dismutase, in Vascular Smooth Muscle: Novel Mechanism to Limit Endothelial Dysfunction in Type 2 Diabetes Mellitus.	PTPN1 LEPR	2.79e-05	6	48	2	29301787
Pubmed	Complement C5a Induces Renal Injury in Diabetic Kidney Disease by Disrupting Mitochondrial Metabolic Agility.	C5 LEPR	2.79e-05	6	48	2	31624141
Pubmed	Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1.	MAPK8IP1 VRK2	2.79e-05	6	48	2	17709393
Pubmed	Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.	LAMP2 C5 PTPRM CETP LEPR	2.80e-05	257	48	5	16335952
Pubmed	Large-scale structural analysis of the classical human protein tyrosine phosphatome.	PTPN1 PTPRM LEPR	3.83e-05	47	48	3	19167335
Pubmed	The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin.	JUP CTNNA2	3.90e-05	7	48	2	12808048
Pubmed	Expression and cell membrane localization of catenins during mouse preimplantation development.	JUP CTNNA2	3.90e-05	7	48	2	8853988
Pubmed	The cell adhesion molecule M-cadherin is not essential for muscle development and regeneration.	JUP CTNNA2	3.90e-05	7	48	2	12052883
Pubmed	Functional analysis of ectodermal β-catenin during external genitalia formation.	JUP CTNNA2	5.19e-05	8	48	2	23480356
Pubmed	Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein.	MAPK8IP1 VRK2	5.19e-05	8	48	2	18286207
Pubmed	The genes coding for alpha and beta catenin (Catna1 and Catnb) and plakoglobin (Jup) map to mouse chromosomes 18, 9, and 11, respectively.	JUP CTNNA2	5.19e-05	8	48	2	7626889
Pubmed	beta-Catenin protects the epidermis from mechanical stresses.	JUP CTNNA2	6.67e-05	9	48	2	23816618
Pubmed	Adipocyte-Derived Hormone Leptin Is a Direct Regulator of Aldosterone Secretion, Which Promotes Endothelial Dysfunction and Cardiac Fibrosis.	PTPN1 LEPR	6.67e-05	9	48	2	26362633
Pubmed	Expression of catenins during mouse embryonic development and in adult tissues.	JUP CTNNA2	6.67e-05	9	48	2	8821035
Pubmed	Lis1 is essential for cortical microtubule organization and desmosome stability in the epidermis.	JUP CTNNA2	1.02e-04	11	48	2	21844209
Pubmed	A role for chromosomal protein HMGN1 in corneal maturation.	JUP CTNNA2	1.02e-04	11	48	2	16466397
Pubmed	Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry.	MAPK8IP1 CTNNA2 MAP1B	1.11e-04	67	48	3	29254152
Pubmed	Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.	SHPRH PCNX1 BACE2 TENM3 PTPRM	1.58e-04	371	48	5	15747579
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	MEPCE JUP RAPGEF6 MAP1B TRIO MAP3K3 RAB11FIP2	1.69e-04	861	48	7	36931259
Pubmed	Cloning and characterization of PTP-K1, a novel nonreceptor protein tyrosine phosphatase highly expressed in bone marrow.	PTPN1 PTPRM	2.21e-04	16	48	2	8875997
Pubmed	Role of topoisomerase IIbeta in the expression of developmentally regulated genes.	CTNNA2 TENM3	2.21e-04	16	48	2	16923961
Pubmed	Desmoplakin is essential in epidermal sheet formation.	JUP CTNNA2	2.50e-04	17	48	2	11781569
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	DIP2A PCNX1 UTP15 RBM10 RWDD1	2.80e-04	420	48	5	28065597
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	MAPK8IP1 DIP2A DMXL2 CMYA5 BACE2 TRIO SBNO1 IFT172	3.44e-04	1285	48	8	35914814
Pubmed	Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.	VRK2 C5 CMYA5 ARRDC1 SLC35B4 SYCP1	3.50e-04	686	48	6	29987050
Pubmed	A novel functional role for MMSET in RNA processing based on the link between the REIIBP isoform and its interaction with the SMN complex.	MAP1B RBM10	3.85e-04	21	48	2	24923560
Pubmed	ARRDC1 and ARRDC3 act as tumor suppressors in renal cell carcinoma by facilitating YAP1 degradation.	MAP1B ARRDC1	3.85e-04	21	48	2	29416926
Pubmed	E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions.	JUP CTNNA2	3.85e-04	21	48	2	15775979
Pubmed	Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability.	PTPN1 JUP VRK2 RAPGEF6 SPCS2	4.55e-04	467	48	5	30194290
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	JUP LAMP2 UPK2 C5 ARRDC1 CETP RYR1	4.61e-04	1016	48	7	19056867
Pubmed	Meiotic gatekeeper STRA8 suppresses autophagy by repressing Nr1d1 expression during spermatogenesis in mice.	LAMP2 SYCP1	4.63e-04	23	48	2	31059511
Pubmed	Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.	CETP LEPR	5.93e-04	26	48	2	19060910
Pubmed	Epidermal development requires ninein for spindle orientation and cortical microtubule organization.	JUP CTNNA2	5.93e-04	26	48	2	30923192
Pubmed	BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.	PTPN1 DMXL2 JUP VRK2	6.47e-04	285	48	4	34369648
Pubmed	WFS1 Spectrum Disorder	MAPK8IP1 PTPN1	6.89e-04	28	48	2	20301750
Pubmed	Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.	CTNNA2 MAP1B	6.89e-04	28	48	2	18839057
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	MAPK8IP1 DIP2A DMXL2 JUP CTNNA2 MAP1B TRIO PIP4K2A	7.01e-04	1431	48	8	37142655
Pubmed	KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.	MAP1B SBNO1 RBM10	7.80e-04	130	48	3	35545047
Pubmed	The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.	PTPN1 JUP MAP3K3	8.52e-04	134	48	3	24658140
Pubmed	In silico prediction of physical protein interactions and characterization of interactome orphans.	PTPN1 JUP MAP3K3	8.89e-04	136	48	3	25402006
Pubmed	Retinoid-related orphan nuclear receptor RORbeta is an early-acting factor in rod photoreceptor development.	ARR3 SLC24A1	9.01e-04	32	48	2	19805139
Pubmed	Severe obesity is associated with novel single nucleotide polymorphisms of the ESR1 and PPARgamma locus in Han Chinese.	PTPN1 LEPR	9.01e-04	32	48	2	19491387
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	MAPK8IP1 PTPN1 DMXL2 CTNNA2 MAP1B TRIO RAB11FIP2	9.04e-04	1139	48	7	36417873
Pubmed	Integration-independent Transgenic Huntington Disease Fragment Mouse Models Reveal Distinct Phenotypes and Life Span in Vivo.	DMXL2 MAP1B	9.58e-04	33	48	2	26025364
Pubmed	Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.	PTPN1 CETP LEPR	9.87e-04	141	48	3	18636124
Pubmed	Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease.	LAMP2 MAP1B	1.02e-03	34	48	2	25915474
Pubmed	Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex.	DMXL2 MAP1B	1.08e-03	35	48	2	37758766
Pubmed	The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability.	JUP CTNNA2 MAP1B RBM10	1.09e-03	328	48	4	23398456
Pubmed	Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.	PCSK5 JARID2	1.34e-03	39	48	2	19010793
ToppCell	nucseq\|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	JARID2 PTPN1 PCNX1 TRIO PTPRM	2.03e-06	193	48	5	779276e775cb2492e8dd36436295a536084a6415
Drug	Ni-fe Reduced Active Center	MAPK8IP1 C5 P2RX2 CETP	4.41e-07	31	46	4	CID005459384
Disease	VACTERL association (implicated_via_orthology)	PCSK5 IFT172	3.55e-05	6	46	2	DOID:14679 (implicated_via_orthology)
Disease	asthma, response to diisocyanate	RAPGEF6 CMYA5 TENM3 CETP RYR1	5.31e-05	261	46	5	EFO_0006995, MONDO_0004979
Disease	Schizophrenia	JARID2 PTPN1 VRK2 RAPGEF6 CTNNA2 CMYA5 SBNO1 PIP4K2A	5.93e-05	883	46	8	C0036341
Disease	venous thromboembolism, fibrinogen measurement	RAPGEF6 SBNO1 LEPR	1.58e-04	67	46	3	EFO_0004286, EFO_0004623
Disease	Tinnitus, response to cisplatin	TENM3 PIP4K2A	2.46e-04	15	46	2	GO_0072718, HP_0000360
Disease	Antibody Deficiency Syndrome	C5 LEPR	3.19e-04	17	46	2	C0003257
Disease	Lipidemias	CETP LEPR	3.19e-04	17	46	2	C1706412
Disease	Hyperlipidemia	CETP LEPR	3.19e-04	17	46	2	C0020473
Disease	Immunologic Deficiency Syndromes	C5 LEPR	5.89e-04	23	46	2	C0021051
Disease	Dyslipidemias	CETP LEPR	6.42e-04	24	46	2	C0242339
Disease	Dyslipoproteinemias	CETP LEPR	6.42e-04	24	46	2	C0598784
Disease	Endogenous Hyperinsulinism	PTPN1 LEPR	7.55e-04	26	46	2	C1257963
Disease	Exogenous Hyperinsulinism	PTPN1 LEPR	7.55e-04	26	46	2	C1257964
Disease	Compensatory Hyperinsulinemia	PTPN1 LEPR	7.55e-04	26	46	2	C1257965
Disease	complex trait	DMXL2 CETP IFT172 LEPR	8.39e-04	271	46	4	EFO_0010578
Disease	TYPE 2 DIABETES MELLITUS	MAPK8IP1 PTPN1	8.76e-04	28	46	2	125853
Disease	Type 2 diabetes mellitus	MAPK8IP1 PTPN1	8.76e-04	28	46	2	cv:C0011860
Disease	Hyperinsulinism	PTPN1 LEPR	8.76e-04	28	46	2	C0020459

Protein segments in the cluster

Peptide	Gene	Start	Entry
STYRSKGFDVTVKYT	BACE2	136	Q9Y5Z0
VSVVFKGTLKYGYTT	CETP	106	P11597
SLITSGYTKKVDITF	ANKEF1	706	Q9NU02
ESVIKEYSSKTYSKV	DMXL2	2091	Q8TDJ6
TDVVLYSLDKYTKTV	ARR3	236	P36575
FSYKLVKTGSVVLTA	ARRDC1	156	Q8N5I2
YGVTSTESYKETLHK	RBM10	906	P98175
KLTLISEDIKSYYTV	PTPN1	141	P18031
YSYETIGKTTKTPED	MAP1B	1921	P46821
TTTSVDVSYKKSYKG	MAGEB3	71	O15480
LTYYTSTSSRQIVKK	SLC24A1	151	O60721
SSYGKRKTLTETIYK	MEPCE	621	Q7L2J0
TSALSYDSVKYTLVV	MAPK8IP1	371	Q9UQF2
ETQKSTYYITGESKE	HSP90AB3P	351	Q58FF7
VKGIIYYVTTSSKLE	PCNX1	1701	Q96RV3
ATTYSSGESYDKKII	PCSK5	356	Q92824
SIYYLGVTSIKKRES	LEPR	1076	P48357
TVRYETTNKTYKTVT	LAMP2	51	P13473
YYKSDLTKDVTTSVL	GNMT	196	Q14749
RQYTLKKTTTYTQGV	JUP	51	P14923
KTNKSSTIYGTESYV	IFT172	141	Q9UG01
YYKINGTTTRTLIKA	P2RX2	306	Q9UBL9
VVLTVKASYVASTKY	CTNNA2	876	P26232
EKKATTTVYINETYT	CCDC175	186	P0C221
EIAYAYKVSITSITV	C5	1556	P01031
VLTTEKEKSYTGIYD	CMYA5	176	Q8N3K9
DTTGKAVYTLTYGKL	DIP2A	356	Q14689
YIEYKTSKEGSTVGV	DIP2A	511	Q14689
SVKKGVIFATYSSLI	SBNO1	391	A3KN83
SIYSLGTTKNTYVEK	RYR1	3171	P21817
TSYDKRYIIKTITSE	PIP4K2A	136	P48426
KAYGALTESVTRKYT	MAP3K3	456	Q99759
GVITLYEITYKAVSS	PTPRM	511	P28827
SSLGIYKVISLFYTV	OR5G3	266	P0C626
VKYTATVTKGAVTYT	JARID2	336	Q92833
GSLDRKVKVYSTTSY	UTP15	266	Q8TED0
KVKVYSTTSYKVVHS	UTP15	271	Q8TED0
YKTVTSSTEKGLIVY	RAPGEF6	1476	Q8TEU7
YSIFKYTSIALVSVG	SLC35B4	116	Q969S0
LTGILYSYSKIVSSI	OR7A10	211	O76100
KKGVSILSIYKYVSS	SHPRH	456	Q149N8
TAITTSEQYYSKEVK	SYCP1	486	Q15431
GILTIYTSYKEKSIF	SPCS2	126	Q15005
SYSGVLYITETDEKK	TENM3	1411	Q9P273
TYTIIQLGKEKYSTS	RAB11FIP2	36	Q7L804
YISYLVKKGTATESS	UPK2	116	O00526
ETVQTTLKFTYSEKY	RWDD1	46	Q9H446
YKYTSTVSTGITDLE	VRK2	451	Q86Y07
LYTCTLSYKTVKAET	ZPBP2	106	Q6X784
YLYKSKLFTSELGVT	TRIO	1531	O75962