Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	BRK	CHD9 CHD7	9.24e-05	6	47	2	SM00592
Domain	BRK_domain	CHD9 CHD7	9.24e-05	6	47	2	IPR006576
Domain	BRK	CHD9 CHD7	9.24e-05	6	47	2	PF07533
Domain	Sec7	CYTH3 CYTH2	6.37e-04	15	47	2	PF01369
Domain	Sec7_alpha_orthog	CYTH3 CYTH2	6.37e-04	15	47	2	IPR023394
Domain	-	CYTH3 CYTH2	6.37e-04	15	47	2	1.10.1000.11
Domain	Sec7	CYTH3 CYTH2	7.27e-04	16	47	2	SM00222
Domain	Sec7_dom	CYTH3 CYTH2	7.27e-04	16	47	2	IPR000904
Domain	SEC7	CYTH3 CYTH2	7.27e-04	16	47	2	PS50190
Domain	RUN	SGSM1 SGSM2	9.24e-04	18	47	2	SM00593
Domain	RUN	SGSM1 SGSM2	1.03e-03	19	47	2	PS50826
Domain	Run_dom	SGSM1 SGSM2	1.03e-03	19	47	2	IPR004012
Domain	RUN	SGSM1 SGSM2	1.03e-03	19	47	2	PF02759
Domain	Chromo_domain	CHD9 CHD7	1.65e-03	24	47	2	IPR023780
Domain	Chromo	CHD9 CHD7	1.94e-03	26	47	2	PF00385
Domain	CHROMO_2	CHD9 CHD7	2.25e-03	28	47	2	PS50013
Domain	CHROMO_1	CHD9 CHD7	2.25e-03	28	47	2	PS00598
Domain	SNF2_N	CHD9 CHD7	2.93e-03	32	47	2	PF00176
Domain	SNF2_N	CHD9 CHD7	2.93e-03	32	47	2	IPR000330
Domain	JMJC	UTY HSPBAP1	2.93e-03	32	47	2	PS51184
Domain	JmjC_dom	UTY HSPBAP1	2.93e-03	32	47	2	IPR003347
Domain	Chromodomain-like	CHD9 CHD7	2.93e-03	32	47	2	IPR016197
Domain	JmjC	UTY HSPBAP1	3.11e-03	33	47	2	SM00558
Domain	CHROMO	CHD9 CHD7	3.11e-03	33	47	2	SM00298
Domain	Chromo/shadow_dom	CHD9 CHD7	3.11e-03	33	47	2	IPR000953
Domain	TBC	SGSM1 SGSM2	6.76e-03	49	47	2	SM00164
Domain	RabGAP-TBC	SGSM1 SGSM2	7.87e-03	53	47	2	PF00566
Domain	TBC_RABGAP	SGSM1 SGSM2	8.46e-03	55	47	2	PS50086
Domain	Rab-GTPase-TBC_dom	SGSM1 SGSM2	8.46e-03	55	47	2	IPR000195
Pubmed	Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes.	CYTH3 CYTH2	1.79e-06	2	47	2	31601460
Pubmed	RNA Sensing by Gut Piezo1 Is Essential for Systemic Serotonin Synthesis.	TLR7 PIEZO1	5.36e-06	3	47	2	32640190
Pubmed	Functional interaction between a novel protein phosphatase 2A regulatory subunit, PR59, and the retinoblastoma-related p107 protein.	PPP2R3B PPP2R3A	5.36e-06	3	47	2	9927208
Pubmed	Phosphoinositide specificity determines which cytohesins regulate β1 integrin recycling.	CYTH3 CYTH2	5.36e-06	3	47	2	22454518
Pubmed	Structural basis and mechanism of autoregulation in 3-phosphoinositide-dependent Grp1 family Arf GTPase exchange factors.	CYTH3 CYTH2	5.36e-06	3	47	2	18042453
Pubmed	Complex regulation of multiple cytohesin-like genes in murine tissues and cells.	CYTH3 CYTH2	5.36e-06	3	47	2	9744817
Pubmed	Diversity in genomic organisation, developmental regulation and distribution of the murine PR72/B" subunits of protein phosphatase 2A.	PPP2R3B PPP2R3A	1.07e-05	4	47	2	18715506
Pubmed	Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors.	CYTH3 CYTH2	1.07e-05	4	47	2	10652308
Pubmed	Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway.	SGSM1 SGSM2	1.07e-05	4	47	2	17509819
Pubmed	Attenuation of cell adhesion in lymphocytes is regulated by CYTIP, a protein which mediates signal complex sequestration.	CYTH3 CYTH2	1.07e-05	4	47	2	12606567
Pubmed	Excitation of Cortical nNOS/NK1R Neurons by Hypocretin 1 is Independent of Sleep Homeostasis.	TACR1 HCRTR1	1.78e-05	5	47	2	29462275
Pubmed	Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains.	CYTH3 CYTH2	1.78e-05	5	47	2	21041639
Pubmed	Interaction protein for cytohesin exchange factors 1 (IPCEF1) binds cytohesin 2 and modifies its activity.	CYTH3 CYTH2	1.78e-05	5	47	2	12920129
Pubmed	PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells.	PPP2R3B PPP2R3A	1.78e-05	5	47	2	10629059
Pubmed	Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens.	PPP2R3B PPP2R3A	2.67e-05	6	47	2	9847399
Pubmed	INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling.	CYTH3 CYTH2	2.67e-05	6	47	2	30355448
Pubmed	Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development.	SCNN1A TRPM6 PKD1L1	2.95e-05	44	47	3	19322198
Pubmed	FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex.	CYTH3 CYTH2	4.98e-05	8	47	2	20080746
Pubmed	The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane.	CYTH3 CYTH2	4.98e-05	8	47	2	17398095
Pubmed	RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and Regulates Melanogenic Enzyme Trafficking in Melanocytes.	DCT SGSM2	4.98e-05	8	47	2	26620560
Pubmed	The N-terminal coiled-coil domain of the cytohesin/ARNO family of guanine nucleotide exchange factors interacts with Galphaq.	CYTH3 CYTH2	6.40e-05	9	47	2	17846866
Pubmed	Interaction of GRASP, a protein encoded by a novel retinoic acid-induced gene, with members of the cytohesin family of guanine nucleotide exchange factors.	CYTH3 CYTH2	7.99e-05	10	47	2	10828067
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TYK2 LRRC8E C2CD3 ATG9A RALGAPA2 CYTH3 SGSM2 PIEZO1	1.06e-04	1105	47	8	35748872
Pubmed	A crucial role for Arf6 in the response of commissural axons to Slit.	CYTH3 CYTH2	3.01e-04	19	47	2	30674481
Pubmed	C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions.	CYTH3 CYTH2	6.14e-04	27	47	2	29420262
Pubmed	A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.	TRPM6 PKD1L1	9.19e-04	33	47	2	19834762
Pubmed	Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos.	BLMH AMZ2	9.75e-04	34	47	2	7490078
GeneFamily	Small G protein signaling modulators	SGSM1 SGSM2	6.93e-06	3	28	2	751
GeneFamily	WD repeat domain containing\|Protein phosphatase 2 regulatory subunits	PPP2R3B PPP2R3A	2.40e-04	15	28	2	696
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PLEKHA7 CYTH3 CYTH2	3.87e-03	206	28	3	682
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS16 SCNN1A TRPM6 CRISPLD1	3.62e-05	177	47	4	c9e8149639551a4c8daa90fcb2b895fdcff2e2ba
ToppCell	wk_15-18-Epithelial-Distal_epithelial_progenitor-epi-tip_intermediate\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	RALGAPA2 PLEKHA7 SGSM2 CLN5	4.30e-05	185	47	4	636505a3d96f75d951ab42bcf8af6ae07abc732d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS16 SCNN1A TRPM6 PPP2R3A	4.39e-05	186	47	4	d65fa6d8e8a195ea10cfde1499d096d6acf7a634
ToppCell	IPF-Endothelial-VE_Peribronchial\|Endothelial / Disease state, Lineage and Cell class	TRPM6 PPP2R3A TACR1 PLEKHA7	5.60e-05	198	47	4	b8bd1ba268480f54451648e01631b615a3401144
ToppCell	kidney_cells-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SCNN1A SLC17A4 CHD9 UTY	5.71e-05	199	47	4	174f6013af6eafa577f84205a62927f2b367fda3
ToppCell	Globus_pallidus-Macroglia-POLYDENDROCYTE-P1-Tnr-Polydendrocyte.Tnr.Pdgfa-Pik3r3_(Pdgfa)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	MYMK DCT PKD1L1	5.81e-05	71	47	3	2220e1b02baa71961cfc85536bafeb313e588bf3
ToppCell	Globus_pallidus-Macroglia-POLYDENDROCYTE-P1-Tnr-Polydendrocyte.Tnr.Pdgfa-Pik3r3_(Pdgfa)-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	MYMK DCT PKD1L1	5.81e-05	71	47	3	cc5de8bbcfefa2bf93cc137c74b49a745d5da229
ToppCell	Substantia_nigra-Macroglia-POLYDENDROCYTE-P1-P1_2-Tnr\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	MYMK DCT PKD1L1	8.30e-05	80	47	3	0d02b242164d27f38f70ed77b106612fc7a3abca
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Chodl_(MGE-derived_cortical_interneurons--Long-range-projecting_interneurons)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	FCRLB TACR1 HCRTR1	8.30e-05	80	47	3	f102890f86fffb30d180a2450b71581181c803cf
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Chodl_(MGE-derived_cortical_interneurons--Long-range-projecting_interneurons)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	FCRLB TACR1 HCRTR1	8.30e-05	80	47	3	1f022bd04de842ec7193e98acae0df17913f4749
ToppCell	Substantia_nigra-Macroglia-POLYDENDROCYTE-P1-P1_2-Tnr-Polydendrocyte.Tnr.Tmem2_(Tmem2)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	MYMK DCT PKD1L1	8.30e-05	80	47	3	b95e4456adb7f7d42825351f010376c10bb35380
ToppCell	Substantia_nigra-Macroglia-POLYDENDROCYTE-P1-P1_2\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	MYMK DCT PKD1L1	8.30e-05	80	47	3	313344cf7309bc17ca131b92a91b24489df577e2
Disease	CHARGE syndrome (implicated_via_orthology)	CHD9 CHD7	5.19e-05	7	47	2	DOID:0050834 (implicated_via_orthology)
Disease	triacylglycerol 50:5 measurement	LRRC8E TM6SF2	2.94e-04	16	47	2	EFO_0010412
Disease	gestational age, birth measurement	PPP2R3A HCRTR1	5.12e-04	21	47	2	EFO_0005112, EFO_0006921
Disease	anxiety disorder	KCNK9 PKD1L1	1.05e-03	30	47	2	EFO_0006788
Disease	liver fat measurement	TM6SF2 LMBRD1	2.15e-03	43	47	2	EFO_0010821
Disease	Mood Disorders	TACR1 KCNK9 HCRTR1	2.45e-03	168	47	3	C0525045

Protein segments in the cluster

Peptide	Gene	Start	Entry
HYICDAYDFEKQIWF	USP26	841	Q9BXU7
EYIKWLTGYCKAYFY	AMZ2	106	Q86W34
CFQIELAHWFYLDFY	DCP2	36	Q8IU60
FYVKYKNFSYLHCQW	CHD7	826	Q9P2D1
KDAFCKDYFHWCYLV	ADAMTS16	1186	Q8TE57
FSYEHFYVIYCKFWE	PPP2R3B	311	Q9Y5P8
FYVIYCKFWELDTDH	PPP2R3B	316	Q9Y5P8
CEEWSFFHAYYYCFI	KCNK9	181	Q9NPC2
CVFFWIPFVYFYYEE	LMBRD1	111	Q9NUN5
YVAEHEDGVYWKYCE	KREMEN1	96	Q96MU8
CYETALHWYAKYFPY	LRRC8E	106	Q6NSJ5
HARVFCYLYELWYKL	RALGAPA2	951	Q2PPJ7
SYEHFYVIYCKFWEL	PPP2R3A	896	Q06190
WADDLYPKIYHSCFF	HCRTR1	206	O43613
SKFWAYADYKYFVSL	HSPBAP1	121	Q96EW2
WDKYYAECHGVIYVI	ARFRP1	86	Q13795
FFVKYKNYSYLHCEW	CHD9	716	Q3L8U1
YLRYKFYDHEAFWTP	C2CD3	1436	Q4AC94
SWYDEVKDFSYPYEH	CRISPLD1	136	Q9H336
IYNICCYWEIHSFYL	ATG9A	151	Q7Z3C6
WFILTDNCLYYFEYT	CYTH2	281	Q99418
WFILTDNCLYYFEYT	CYTH3	286	O43739
YALYLSAYHERKFWF	DPY19L4	66	Q7Z388
YLFFWDKVERCYFFL	BLMH	101	Q13867
ICLHAFYYAIWKRYG	EDEM1	456	Q92611
GWYDKVVYKLHYYHD	FCRLB	126	Q6BAA4
FVYHWKAITHYYIET	FHIP2A	26	Q5W0V3
AILVSYFCEYWLFYT	SLC17A4	296	Q9Y2C5
DYRKHSSWGYCYYKL	SCNN1A	446	P37088
YCKFTEYLEDFHVWL	PKD1L1	1926	Q8TDX9
FWFYYKSRKNLLHCY	PRIMPOL	86	Q96LW4
VYFYYNAFHWAIKAF	UTY	136	O14607
NEWYYGLFYCKFHNF	TACR1	96	P25103
WFVLADYCLFYYKDS	PLEKHA7	186	Q6IQ23
THFYFCYRWFLLDFK	SGSM2	906	O43147
WPFYHFYAEQLSYLC	SLC25A44	201	Q96H78
IVHKQFYLFYNFEYW	CLN5	316	O75503
VYEFYSAPIVKFWFY	TRPM6	831	Q9BX84
YCYFKKPEIYTHWHD	HEATR9	71	A2RTY3
ENCWYFGLTFCKIYY	TAAR2	106	Q9P1P5
DYTHFYFCYRWFLLD	SGSM1	1046	Q2NKQ1
VYDFFVWLHYYSVRD	DCT	181	P40126
HLYFWDVWYIYHFCK	TLR7	861	Q9NYK1
WYFVKCIYFALSAYQ	PIEZO1	2066	Q92508
FICYWDGTVHYLLYL	TM6SF2	111	Q9BZW4
VKFIFYSSDKYWYFS	ZFYVE16	1071	Q7Z3T8
ECLKEYKFYYASDVW	TYK2	1071	P29597
FEDWDYTYVHSFYHC	MYMK	171	A6NI61