Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	FOXL2 ZFHX4 HOXD11 BHLHE22 MAFA WT1 SKOR1 NHLH1 ZFHX2 NKX1-1 DMRTA2 NR6A1 DBP PHOX2B RAX HSF5 TLX1 ZNF513 NKX1-2	5.38e-08	1244	72	19	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	FOXL2 ZFHX4 HOXD11 BHLHE22 MAFA WT1 SKOR1 NHLH1 ZFHX2 NKX1-1 DMRTA2 NR6A1 DBP PHOX2B RAX HSF5 TLX1 ZNF513 NKX1-2	7.56e-08	1271	72	19	GO:0000987
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	FOXL2 ZFHX4 HOXD11 PURB BHLHE22 MAFA WT1 SKOR1 NHLH1 ZFHX2 NKX1-1 DMRTA2 NR6A1 DBP PHOX2B RAX HSF5 TLX1 ZNF513 NKX1-2	1.30e-07	1459	72	20	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	FOXL2 ZFHX4 HOXD11 PURB BHLHE22 MAFA WT1 SKOR1 NHLH1 ZFHX2 NKX1-1 DMRTA2 NR6A1 DBP PHOX2B RAX TLX1 ZNF513 NKX1-2	3.88e-07	1412	72	19	GO:0000981
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	FOXL2 MAFA WT1 NHLH1 NR6A1 DBP PHOX2B RAX TLX1	1.78e-04	560	72	9	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	FOXL2 MAFA WT1 NHLH1 NR6A1 DBP PHOX2B RAX TLX1	1.93e-04	566	72	9	GO:0001216
GeneOntologyMolecularFunction	armadillo repeat domain binding	STRN3 STRN4	4.54e-04	9	72	2	GO:0070016
GeneOntologyMolecularFunction	protein phosphatase binding	STRN3 STRN4 KCNQ1 IRS2 ITPR1	9.69e-04	210	72	5	GO:0019903
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	STRN3 FOXL2 PURB BHLHE22 MAFA WT1 MED14 NHLH1 IER5 IRF2BPL NR6A1 TAF4 DBP SPAG8 PHOX2B RAX TLX1 ZNF513	1.43e-06	1390	74	18	GO:0045944
GeneOntologyCellularComponent	chromatin	FOXL2 ZFHX4 HOXD11 BHLHE22 MAFA NHLH1 ZFHX2 NKX1-1 DMRTA2 NR6A1 TAF4 DBP PHOX2B RAX TLX1 NKX1-2	4.09e-05	1480	73	16	GO:0000785
Domain	Homeobox_CS	ZFHX4 HOXD11 ZFHX2 NKX1-1 PHOX2B RAX TLX1 NKX1-2	7.16e-07	186	74	8	IPR017970
Domain	Homeobox	ZFHX4 HOXD11 ZFHX2 NKX1-1 PHOX2B RAX TLX1 NKX1-2	3.98e-06	234	74	8	PF00046
Domain	HOMEOBOX_1	ZFHX4 HOXD11 ZFHX2 NKX1-1 PHOX2B RAX TLX1 NKX1-2	4.24e-06	236	74	8	PS00027
Domain	HOX	ZFHX4 HOXD11 ZFHX2 NKX1-1 PHOX2B RAX TLX1 NKX1-2	4.38e-06	237	74	8	SM00389
Domain	HOMEOBOX_2	ZFHX4 HOXD11 ZFHX2 NKX1-1 PHOX2B RAX TLX1 NKX1-2	4.66e-06	239	74	8	PS50071
Domain	Homeobox_dom	ZFHX4 HOXD11 ZFHX2 NKX1-1 PHOX2B RAX TLX1 NKX1-2	4.66e-06	239	74	8	IPR001356
Domain	Striatin	STRN3 STRN4	4.63e-05	3	74	2	PF08232
Domain	Striatin_N	STRN3 STRN4	4.63e-05	3	74	2	IPR013258
Domain	Homeodomain-like	ZFHX4 HOXD11 ZFHX2 NKX1-1 PHOX2B RAX TLX1 NKX1-2	4.98e-05	332	74	8	IPR009057
Domain	-	ZFHX4 HOXD11 ZFHX2 PHOX2B RAX TLX1 NKX1-2	1.29e-04	283	74	7	1.10.10.60
Domain	Homeobox_metazoa	HOXD11 NKX1-1 TLX1 NKX1-2	4.48e-04	90	74	4	IPR020479
Domain	Ion_trans_dom	KCNA3 KCNQ1 CACNA1I ITPR1	1.09e-03	114	74	4	IPR005821
Domain	Ion_trans	KCNA3 KCNQ1 CACNA1I ITPR1	1.09e-03	114	74	4	PF00520
Domain	Filament	KRT1 KRT3 IFFO2	2.81e-03	71	74	3	SM01391
Domain	Filament	KRT1 KRT3 IFFO2	3.04e-03	73	74	3	PF00038
Domain	IF	KRT1 KRT3 IFFO2	3.41e-03	76	74	3	IPR001664
Domain	Keratin_2_head	KRT1 KRT3	4.04e-03	24	74	2	IPR032444
Domain	Keratin_2_head	KRT1 KRT3	4.04e-03	24	74	2	PF16208
Domain	Keratin_II	KRT1 KRT3	4.73e-03	26	74	2	IPR003054
Domain	ZnF_U1	ZFHX4 ZFHX2	5.87e-03	29	74	2	SM00451
Domain	Znf_U1	ZFHX4 ZFHX2	5.87e-03	29	74	2	IPR003604
Domain	VG_K_chnl	KCNA3 KCNQ1	7.55e-03	33	74	2	IPR028325
Pathway	REACTOME_DEVELOPMENTAL_BIOLOGY	KRT1 KRT3 CNOT11 FOXL2 HOXD11 MAFA WT1 MED14 SIAH2 CACNA1I IRS2 KAZN NR6A1 VASP	5.37e-05	1432	43	14	M509
Pubmed	A census of human transcription factors: function, expression and evolution.	FOXL2 ZFHX4 HOXD11 BHLHE22 MAFA WT1 SKOR1 NHLH1 ZFHX2 DMRTA2 NR6A1 DBP PHOX2B RAX HSF5 TLX1	8.29e-11	908	75	16	19274049
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	FOXL2 HOXD11 BHLHE22 MAFA SKOR1 NHLH1 DMRTA2 NR6A1 DBP PHOX2B RAX HSF5	2.03e-09	544	75	12	28473536
Pubmed	The Wilms tumor suppressor gene wt1 is required for development of the spleen.	WT1 TLX1	4.59e-06	2	75	2	10469569
Pubmed	Epigenetic Changes in the Methylation Patterns of KCNQ1 and WT1 after a Weight Loss Intervention Program in Obese Stroke Patients.	WT1 KCNQ1	4.59e-06	2	75	2	26238466
Pubmed	Hox11 is required to maintain normal Wt1 mRNA levels in the developing spleen.	WT1 TLX1	4.59e-06	2	75	2	10822272
Pubmed	Functional coupling of the metabotropic glutamate receptor, InsP3 receptor and L-type Ca2+ channel in mouse CA1 pyramidal cells.	GRM5 ITPR1	4.59e-06	2	75	2	22586220
Pubmed	Aberrant and constitutive expression of FOXL2 impairs ovarian development and functions in mice.	FOXL2 WT1 PTCH1	6.41e-06	17	75	3	32945847
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	STRN3 KCNA3 SYT3 KCNJ4 PURB STRN4 DCHS1 NLGN2 TAF4 GRM5 KHSRP	6.74e-06	963	75	11	28671696
Pubmed	Midline-derived Shh regulates mesonephric tubule formation through the paraxial mesoderm.	HOXD11 WT1 PTCH1	7.68e-06	18	75	3	24370450
Pubmed	Repression by PRDM13 is critical for generating precision in neuronal identity.	BHLHE22 PHOX2B TLX1	1.07e-05	20	75	3	28850031
Pubmed	A genome-wide association study confirms previously reported loci for type 2 diabetes in Han Chinese.	C2CD4B KCNQ1	1.37e-05	3	75	2	21799836
Pubmed	Genetic mapping of a Ptch1-associated rhabdomyosarcoma susceptibility locus on mouse chromosome 2.	WT1 PTCH1	1.37e-05	3	75	2	15475264
Pubmed	A comprehensive negative regulatory program controlled by Brn3b to ensure ganglion cell specification from multipotential retinal precursors.	ZFHX4 BHLHE22 WT1	1.65e-05	23	75	3	18367606
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	STRN3 CNOT11 PURB STRN4 MTMR1 IRF2BPL TAF4 VASP HSF5	1.75e-05	689	75	9	36543142
Pubmed	Steroidogenic differentiation and PKA signaling are programmed by histone methyltransferase EZH2 in the adrenal cortex.	FOXL2 WT1 PTCH1	2.14e-05	25	75	3	30541888
Pubmed	Gene expression is dynamically regulated in retinal progenitor cells prior to and during overt cellular differentiation.	BHLHE22 NHLH1 RAX	2.71e-05	27	75	3	24148613
Pubmed	Behavioral abnormalities observed in Zfhx2-deficient mice.	ZFHX4 ZFHX2	2.75e-05	4	75	2	23300874
Pubmed	Spatial and temporal deletion reveals a latent effect of Megf8 on the left-right patterning and heart development.	MEGF8 WT1	2.75e-05	4	75	2	32203821
Pubmed	Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain.	STRN3 STRN4	2.75e-05	4	75	2	10748158
Pubmed	FOXL2 transcriptionally represses Sf1 expression by antagonizing WT1 during ovarian development in mice.	FOXL2 WT1	2.75e-05	4	75	2	24451388
Pubmed	Siah2 integrates mitogenic and extracellular matrix signals linking neuronal progenitor ciliogenesis with germinal zone occupancy.	SIAH2 PTCH1	2.75e-05	4	75	2	33082319
Pubmed	The c-Ski family member and transcriptional regulator Corl2/Skor2 promotes early differentiation of cerebellar Purkinje cells.	SKOR1 PTCH1 ITPR1	3.04e-05	28	75	3	24491816
Pubmed	Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate.	TMEFF1 NR6A1 PTCH1	3.75e-05	30	75	3	20583170
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	PIP4P1 TMEM151B WT1 IRF2BPL PTCH1 NYAP1 VASP	4.05e-05	430	75	7	35044719
Pubmed	Embryonic forebrain transcriptome of mice with polyalanine expansion mutations in the ARX homeobox gene.	KCNA3 ASPHD1 PTCH1	4.15e-05	31	75	3	27798109
Pubmed	Targeted Disruption of Lats1 and Lats2 in Mice Impairs Testis Development and Alters Somatic Cell Fate.	FOXL2 WT1 PTCH1	4.15e-05	31	75	3	36362374
Pubmed	Hox11 expression characterizes developing zeugopod synovial joints and is coupled to postnatal articular cartilage morphogenesis into functional zones in mice.	HOXD11 TLX1	4.57e-05	5	75	2	34010606
Pubmed	Microcystic Stromal Tumor: A Distinctive Ovarian Sex Cord-Stromal Neoplasm Characterized by FOXL2, SF-1, WT-1, Cyclin D1, and β-catenin Nuclear Expression and CTNNB1 Mutations.	FOXL2 WT1	4.57e-05	5	75	2	26200099
Pubmed	The armadillo repeat domain of the APC tumor suppressor protein interacts with Striatin family members.	STRN3 STRN4	4.57e-05	5	75	2	18502210
Pubmed	The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.	WT1 SIAH2 PTCH1 ITPR1	6.43e-05	99	75	4	19730683
Pubmed	Pleiotropic patterning response to activation of Shh signaling in the limb apical ectodermal ridge.	HOXD11 PTCH1	6.84e-05	6	75	2	21465622
Pubmed	Derivation of lung mesenchymal lineages from the fetal mesothelium requires hedgehog signaling for mesothelial cell entry.	WT1 PTCH1	6.84e-05	6	75	2	24130328
Pubmed	Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.	KCNA3 KCNJ4 MTMR1 LRRC4B NLGN2	6.93e-05	197	75	5	36604605
Pubmed	In vitro differentiation of mouse pluripotent stem cells into corticosteroid-producing adrenocortical cells.	FOXL2 HOXD11 WT1	7.10e-05	37	75	3	39178848
Pubmed	Characterization of the zinc-induced Shank3 interactome of mouse synaptosome.	PURB LRRC4B NLGN2 ITPR1	9.35e-05	109	75	4	29111324
Pubmed	FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction.	MAFA IRS2	9.57e-05	7	75	2	16154098
Pubmed	Formation of the rete testis during mouse embryonic development.	FOXL2 WT1	9.57e-05	7	75	2	32852840
Pubmed	A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny.	WT1 TLX1	9.57e-05	7	75	2	15944191
Pubmed	Notch1 is essential for postnatal hair follicle development and homeostasis.	KRT1 PTCH1	9.57e-05	7	75	2	15978571
Pubmed	Wt1 Positive dB4 Neurons in the Hindbrain Are Crucial for Respiration.	WT1 PHOX2B	9.57e-05	7	75	2	33328840
Pubmed	Hox10 and Hox11 genes are required to globally pattern the mammalian skeleton.	HOXD11 TLX1	1.27e-04	8	75	2	12869760
Pubmed	WT1 regulates the development of the posterior taste field.	WT1 PTCH1	1.27e-04	8	75	2	24803588
Pubmed	Hox11 paralogous genes are essential for metanephric kidney induction.	HOXD11 WT1	1.27e-04	8	75	2	12050119
Pubmed	KCNE2 forms potassium channels with KCNA3 and KCNQ1 in the choroid plexus epithelium.	KCNA3 KCNQ1	1.27e-04	8	75	2	21859894
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	RIN3 MEGF8 STRN4 MED14 SIAH2 NLGN2 IRS2 PTCH1 TESK1 FBXO46	1.28e-04	1105	75	10	35748872
Pubmed	Sex reversal in C57BL/6J XY mice caused by increased expression of ovarian genes and insufficient activation of the testis determining pathway.	FOXL2 WT1 PTCH1	1.46e-04	47	75	3	22496664
Pubmed	GATA6 is a crucial factor for Myocd expression in the visceral smooth muscle cell differentiation program of the murine ureter.	WT1 PTCH1 PHOX2B	1.55e-04	48	75	3	35905011
Pubmed	MicroRNAs-140-5p/140-3p modulate Leydig cell numbers in the developing mouse testis.	FOXL2 WT1	1.64e-04	9	75	2	23616593
Pubmed	Transcriptional regulatory control of mammalian nephron progenitors revealed by multi-factor cistromic analysis and genetic studies.	HOXD11 WT1	1.64e-04	9	75	2	29377931
Pubmed	Eye formation in the absence of retina.	FOXL2 RAX	1.64e-04	9	75	2	18675797
Pubmed	Testis formation in XX individuals resulting from novel pathogenic variants in Wilms' tumor 1 (WT1) gene.	FOXL2 WT1	1.64e-04	9	75	2	32493750
Pubmed	Mafa-dependent GABAergic activity promotes mouse neonatal apneas.	MAFA PHOX2B	1.64e-04	9	75	2	35672398
Pubmed	Loss of function mutation in the palmitoyl-transferase HHAT leads to syndromic 46,XY disorder of sex development by impeding Hedgehog protein palmitoylation and signaling.	FOXL2 WT1	1.64e-04	9	75	2	24784881
Pubmed	Bhlhb5 and Prdm8 form a repressor complex involved in neuronal circuit assembly.	PRDM8 BHLHE22	1.64e-04	9	75	2	22284184
Pubmed	Impaired skin and hair follicle development in Runx2 deficient mice.	KRT1 PTCH1	1.64e-04	9	75	2	18262513
Pubmed	Mouse limbs expressing only the Gli3 repressor resemble those of Sonic hedgehog mutants.	HOXD11 PTCH1	1.64e-04	9	75	2	23644062
Pubmed	Molecular architecture of the developing mouse brain.	NHLH1 PTCH1 PHOX2B RAX	1.96e-04	132	75	4	34321664
Pubmed	Inhibition of Sox2-dependent activation of Shh in the ventral diencephalon by Tbx3 is required for formation of the neurohypophysis.	FOXL2 PTCH1 RAX	1.97e-04	52	75	3	23674600
Pubmed	Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death.	NHLH1 TAF4 BBC3	1.97e-04	52	75	3	35361962
Pubmed	Yes-associated protein and WW-containing transcription regulator 1 regulate the expression of sex-determining genes in Sertoli cells, but their inactivation does not cause sex reversal.	FOXL2 WT1	2.04e-04	10	75	2	28637242
Pubmed	Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity.	VASP ITPR1	2.04e-04	10	75	2	22427743
Pubmed	The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis.	HOXD11 PTCH1	2.04e-04	10	75	2	23141541
Pubmed	The -KTS splice variant of WT1 is essential for ovarian determination in mice.	FOXL2 WT1	2.04e-04	10	75	2	37917714
Pubmed	Function and regulation of Alx4 in limb development: complex genetic interactions with Gli3 and Shh.	HOXD11 PTCH1	2.04e-04	10	75	2	16039644
Pubmed	Complete male-to-female sex reversal in XY mice lacking the miR-17~92 cluster.	FOXL2 WT1	2.04e-04	10	75	2	38714644
Pubmed	Paired-related homeobox genes cooperate in handplate and hindlimb zeugopod morphogenesis.	HOXD11 PTCH1	2.04e-04	10	75	2	9882503
Pubmed	Essential role for Sonic hedgehog during hair follicle morphogenesis.	KRT1 PTCH1	2.04e-04	10	75	2	9882493
Pubmed	Replicated anterior zeugopod (raz): a polydactylous mouse mutant with lowered Shh signaling in the limb bud.	HOXD11 PTCH1	2.49e-04	11	75	2	14597572
Pubmed	Ex vivo cultures combined with vivo-morpholino induced gene knockdown provide a system to assess the role of WT1 and GATA4 during gonad differentiation.	FOXL2 WT1	2.49e-04	11	75	2	28426816
Pubmed	Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development.	HOXD11 PTCH1	2.99e-04	12	75	2	9152009
Pubmed	Shox2 is required for the proper development of the facial motor nucleus and the establishment of the facial nerves.	PTCH1 PHOX2B	2.99e-04	12	75	2	26156498
Pubmed	Bile salt-stimulated lipase plays an unexpected role in arthritis development in rodents.	FOXL2 WT1	2.99e-04	12	75	2	23071697
Pubmed	Ptch1 is essential for cochlear marginal cell differentiation and stria vascularis formation.	KCNQ1 PTCH1	2.99e-04	12	75	2	38602877
Pubmed	Hoxa11 and Hoxd11 regulate chondrocyte differentiation upstream of Runx2 and Shox2 in mice.	HOXD11 PTCH1	2.99e-04	12	75	2	22916278
Pubmed	Epithelial-to-mesenchymal transition in epicardium is independent of Snail1.	KRT1 WT1	2.99e-04	12	75	2	23097346
Pubmed	Germ cells are not required to establish the female pathway in mouse fetal gonads.	FOXL2 WT1	3.52e-04	13	75	2	23091613
Pubmed	Gorab Is Required for Dermal Condensate Cells to Respond to Hedgehog Signals during Hair Follicle Morphogenesis.	KRT1 PTCH1	3.52e-04	13	75	2	26967474
Pubmed	The splanchnic mesodermal plate directs spleen and pancreatic laterality, and is regulated by Bapx1/Nkx3.2.	WT1 TLX1	3.52e-04	13	75	2	15329346
Pubmed	Role of epidermal primary cilia in the homeostasis of skin and hair follicles.	KRT1 PTCH1	3.52e-04	13	75	2	21429982
Pubmed	Long-term expandable mouse and human-induced nephron progenitor cells enable kidney organoid maturation and modeling of plasticity and disease.	HOXD11 WT1	3.52e-04	13	75	2	38692273
Pubmed	The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons.	NHLH1 PHOX2B	3.52e-04	13	75	2	9539123
Pubmed	PCP effector gene Inturned is an important regulator of cilia formation and embryonic development in mammals.	HOXD11 PTCH1	3.52e-04	13	75	2	20067783
Pubmed	HectD1 E3 ligase modifies adenomatous polyposis coli (APC) with polyubiquitin to promote the APC-axin interaction.	STRN3 STRN4	3.52e-04	13	75	2	23277359
Pubmed	Eya1 and Six1 are essential for early steps of sensory neurogenesis in mammalian cranial placodes.	NHLH1 PHOX2B	3.52e-04	13	75	2	15496442
Pubmed	Formation of brainstem (nor)adrenergic centers and first-order relay visceral sensory neurons is dependent on homeodomain protein Rnx/Tlx3.	PHOX2B TLX1	4.11e-04	14	75	2	11581159
Pubmed	Two distinct origins for Leydig cell progenitors in the fetal testis.	FOXL2 MAFA	4.11e-04	14	75	2	21255566
Pubmed	Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors.	HOXD11 PTCH1	4.11e-04	14	75	2	15930098
Pubmed	Gene Regulatory and Expression Differences between Mouse and Pig Limb Buds Provide Insights into the Evolutionary Emergence of Artiodactyl Traits.	HOXD11 PTCH1	4.11e-04	14	75	2	32268095
Pubmed	Hoxa11 and Hoxd11 regulate branching morphogenesis of the ureteric bud in the developing kidney.	HOXD11 WT1	4.11e-04	14	75	2	11493536
Pubmed	Planar cell polarity effector gene Fuzzy regulates cilia formation and Hedgehog signal transduction in mouse.	HOXD11 PTCH1	4.11e-04	14	75	2	19877275
Pubmed	Hox11 genes are required for regional patterning and integration of muscle, tendon and bone.	HOXD11 TLX1	4.11e-04	14	75	2	24154528
Pubmed	Gli3 (Xt) and formin (ld) participate in the positioning of the polarising region and control of posterior limb-bud identity.	HOXD11 PTCH1	4.11e-04	14	75	2	9834182
Pubmed	The chromatin remodeler Mi-2beta is required for establishment of the basal epidermis and normal differentiation of its progeny.	KRT1 PTCH1	4.11e-04	14	75	2	17360773
Pubmed	Regulation of downstream neuronal genes by proneural transcription factors during initial neurogenesis in the vertebrate brain.	NHLH1 PHOX2B	4.11e-04	14	75	2	27923395
Pubmed	Mouse Twist is required for fibroblast growth factor-mediated epithelial-mesenchymal signalling and cell survival during limb morphogenesis.	HOXD11 PTCH1	4.11e-04	14	75	2	12175489
Pubmed	Basic helix-loop-helix transcription factors cooperate to specify a cortical projection neuron identity.	BHLHE22 NHLH1	4.11e-04	14	75	2	18160702
Pubmed	Headbobber: a combined morphogenetic and cochleosaccular mouse model to study 10qter deletions in human deafness.	KCNQ1 NKX1-2	4.11e-04	14	75	2	23457544
Pubmed	Positive autofeedback regulation of Ptf1a transcription generates the levels of PTF1A required to generate itch circuit neurons.	BHLHE22 TLX1	4.73e-04	15	75	2	32241803
Pubmed	Conditional ablation of the heparan sulfate-synthesizing enzyme Ext1 leads to dysregulation of bone morphogenic protein signaling and severe skeletal defects.	HOXD11 PTCH1	4.73e-04	15	75	2	20404326
Pubmed	Lineage specification of ovarian theca cells requires multicellular interactions via oocyte and granulosa cells.	FOXL2 WT1	4.73e-04	15	75	2	25917826
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	FCGBP MEGF8 SYT3 STRN4 LRRC4B HSPBP1 DBP BBC3 FBXO46 VASP	2.41e-05	1192	75	10	chr19q13
GeneFamily	WD repeat domain containing\|Protein phosphatase 2 regulatory subunits	STRN3 STRN4	7.69e-04	15	50	2	696
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZFHX4 ZFHX2	7.69e-04	15	50	2	529
GeneFamily	NKL subclass homeoboxes and pseudogenes	NKX1-1 TLX1 NKX1-2	8.42e-04	67	50	3	519
GeneFamily	Zinc fingers C2H2-type\|PR/SET domain family	PRDM8 PRDM6	9.93e-04	17	50	2	1197
GeneFamily	Protein phosphatase catalytic subunits\|STRIPAK complex	STRN3 STRN4	1.38e-03	20	50	2	1371
GeneFamily	Keratins, type II	KRT1 KRT3	2.52e-03	27	50	2	609
GeneFamily	Phosphoinositide phosphatases	PIP4P1 MTMR1	3.53e-03	32	50	2	1079
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	PRDM8 PRDM6	3.97e-03	34	50	2	487
GeneFamily	Potassium voltage-gated channels	KCNA3 KCNQ1	5.47e-03	40	50	2	274
ToppCell	Cerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb\|Cerebellum / BrainAtlas - Mouse McCarroll V32	PRDM8 KCNA3 PURB BHLHE22 SKOR1	5.33e-06	149	75	5	6e9ca280a599d96f8956ef26f2a46b9484de5488
ToppCell	Cerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	PRDM8 PURB TMEM151B SKOR1 NYAP1	9.28e-06	167	75	5	9efb9511a211d0824bb97f82c1a5860c43d2138f
ToppCell	Cerebellum-Neuronal-Inhibitory\|Cerebellum / BrainAtlas - Mouse McCarroll V32	PRDM8 PURB TMEM151B SKOR1 NYAP1	9.28e-06	167	75	5	904c613aac3f9919a432b110bb1dcc832b5aec0a
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Neuronal-Neuron\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	DNAAF2 MED14 NHLH1 IRF2BPL NLGN2	1.16e-05	175	75	5	2812ac2ef41d245db544697fb6da1883361c96e8
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYT3 KCNJ4 GRM5 NYAP1 ITPR1	1.30e-05	179	75	5	a3922476f33d2e4137a12dbda21a1703dff79684
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZFHX4 LRRC4B NLGN2 PTCH1 PRDM6	1.44e-05	183	75	5	12daaea821e49bc94a01e2496331e92a80d27339
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PURB BHLHE22 TMEM151B SKOR1 ITPR1	1.64e-05	188	75	5	1efbc99bcd6542e5d9fa91edb7c4295167914786
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Intermediate\|5w / Sample Type, Dataset, Time_group, and Cell type.	ZFHX4 MEGF8 TMEM151B LRRC4B NLGN2	2.21e-05	200	75	5	c92e4fc0442404481fcac623d691dae6215b852d
Disease	Schizoaffective disorder-bipolar type	PURB PTCH1	7.08e-04	16	73	2	EFO_0009965
Disease	kidney volume	HOXD11 PTCH1	9.00e-04	18	73	2	EFO_0600044
Disease	birth weight, parental genotype effect measurement	ZFHX4 WT1 KCNQ1 PTCH1	1.33e-03	192	73	4	EFO_0004344, EFO_0005939
Disease	Pancreatic Neoplasm	WT1 SSTR1 PTCH1	1.98e-03	100	73	3	C0030297
Disease	electrocardiography	KCNA3 WT1 KCNQ1 LRRC4B YTHDC2 PRDM6	2.01e-03	530	73	6	EFO_0004327
Disease	obesity (implicated_via_orthology)	ZFHX4 DCHS1 ZFHX2 ITPR1	2.01e-03	215	73	4	DOID:9970 (implicated_via_orthology)
Disease	Malignant neoplasm of pancreas	WT1 SSTR1 PTCH1	2.09e-03	102	73	3	C0346647

Protein segments in the cluster

Peptide	Gene	Start	Entry
LLPPPGGGGGGSAGS	BHLHE22	76	Q8NFJ8
GGPGSPRGGGTVGPG	BBC3	156	Q96PG8
GSCPGSAGPGGGGEE	DMRTA2	261	Q96SC8
GCEGGGGPNPGPAGG	MTMR1	11	Q13613
PGVPAAGGPAAGGGG	KCNJ4	91	P48050
GGPGAGGPYPRGGSL	DCHS1	3011	Q96JQ0
GGSTPGSGGPPREGG	KCNQ1	621	P51787
PPYPGPGGGGWGSGS	MPLKIP	11	Q8TAP9
SGGGGPGPGPGAAAS	KAZN	41	Q674X7
ATGGAGCAGAGPGGP	GRM5	976	P41594
PSFCAPSPGTGGGGG	MAFA	66	Q8NHW3
GPLSAGGPGKPGGGG	ITPR1	1771	Q14643
PGGENSPGGGGSPCL	DNAAF2	456	Q9NVR5
GCSEAGGPSPGGPGD	ASPHD1	121	Q5U4P2
GPGSLGSPGGFGPGG	KRT3	151	P12035
GGGGGPDAPLGTLCG	C2CD4B	131	A6NLJ0
GAPGGPACLGGTPGV	IRF2BPL	291	Q9H1B7
GGGGRPGCAYPGSPG	FBXO46	281	Q6PJ61
GGGYGGGYGPVCPPG	KRT1	136	P04264
PPSPGKGGGGGGGTA	FOXL2	31	P58012
GGPWGPMGGGCCPPA	MEGF8	2741	Q7Z7M0
VADGGGAPPQGGCGG	KCNA3	66	P22001
GAPPQGGCGGGGCDR	KCNA3	71	P22001
GGPGPGAGGVAAAGP	OSBP	56	P22059
GGGGGSGGPPSAPAP	MED14	16	O60244
ATSGPGPVKCGGGGG	PRDM6	141	Q9NQX0
TPGQPGGLVGCPGSG	IRS2	1221	Q9Y4H2
STGGGCGGPGPGALP	IRS2	1301	Q9Y4H2
CGSGGGGISPKGSGP	CHFR	206	Q96EP1
CGGGAGPDGAGPGGP	NHLH1	26	Q02575
GGPTGGCGVGGQPLG	LINC01599	236	Q8WXQ3
GPGFCGPLSSGTGGP	FCGBP	4276	Q9Y6R7
TGSPGAPGRGPGGAG	CACNA1I	1766	Q9P0X4
GDPRTGAGGGGGSPC	HOXD11	211	P31277
ALAFGCPPGGGGGGC	IFFO2	11	Q5TF58
GGPAGTPPGGGALLG	DBP	16	Q10586
SCPPGVGVGPGTGGS	BTBD2	11	Q9BX70
PGGGAPGGPGLGLGS	NLGN2	21	Q8NFZ4
GPGGSGAGPGGGLTP	PIP4P1	26	Q86T03
GGGGGPCGFQPASRG	PURB	11	Q96QR8
SNPSGGGCGGKGPPG	LRRC4B	676	Q9NT99
GGGGGGGSPPCLVVR	RIN3	966	Q8TB24
GGGLAGPPLGGGGPT	NYAP1	231	Q6ZVC0
PPPSGGGGGGGSAGF	NR6A1	6	Q15406
GGGSAGGPSQPPGGG	KHSRP	51	Q92945
PPASQGCSSGGGGGG	HSPBP1	16	Q9NZL4
AAGVGGGPAGCPAPG	IER5	221	Q5VY09
GGGPGSGEAGTGAPC	SYT3	286	Q9BQG1
DCPGPGSGAEGSGPG	TAF4	1021	O00268
LSPPGPGGGGGTAGA	HSF5	51	Q4G112
GGGGPGCGAEMAPGP	SKOR1	306	P84550
ATGASGPAGPGGPGG	SKOR1	351	P84550
PSPGSCGEGGGSRGP	SSTR1	16	P30872
SPGGNGAAGGGGPPA	STRN3	31	Q13033
GPGSGPGSGPGHGSG	SPAG8	176	Q99932
SSLPCPGGRLGGGGG	SPAG8	466	Q99932
SPRAGPGPGGGAGCG	TMEM151B	456	Q8IW70
PGPGGGAGCGGSRFS	TMEM151B	461	Q8IW70
SAPTGGGGGPGPGAG	NKX1-1	361	Q15270
GPGAGPGTGLPGGLS	NKX1-1	371	Q15270
GGGSGGSPGPPGTGA	NKX1-2	246	Q9UD57
NGGCGSLPSGGGGLP	PRDM8	556	Q9NQV8
GGSGCIGAPGRPAGG	PTCH1	16	Q13635
SGPGGGGGAGPVSPQ	SIAH2	56	O43255
AGPGSGGGPAGGALP	RAX	226	Q9Y2V3
SPPQGCGGGGGGIAL	AMMECR1	71	Q9Y4X0
CGGGGGGIALSPPPS	AMMECR1	76	Q9Y4X0
GPGSGSGGPGGPAGR	CNOT11	46	Q9UKZ1
PTGEGPCCGAGGPGG	ZNF513	126	Q8N8E2
PCCGAGGPGGGPLLP	ZNF513	131	Q8N8E2
PGPGGDGSPGSGIEC	ZFHX4	601	Q86UP3
PESPGAGGTSGGPGG	ZFHX2	2041	Q9C0A1
PSLGGGGGCALPVSG	WT1	16	P19544
PGGTGGGPGRGRPSS	TESK1	26	Q15569
DNDPPGSCGPTGGGG	USP38	1016	Q8NB14
AGAYGTGGPGGPGGP	TLX1	71	P31314
QPAPGGGGGGGPSPC	YTHDC2	11	Q9H6S0
GPSPCGPGGGGRAKG	YTHDC2	21	Q9H6S0
KGGGGGGSPGPTAGP	STRN4	46	Q9NRL3
NQPPGGGGGSGGDCP	TMEFF1	41	Q8IYR6
PGPWGRCTGDCGPGG	THSD7B	46	Q9C0I4
PSCGANGGGGGGPSP	PHOX2B	206	Q99453
NGGGGGGPSPAGAPG	PHOX2B	211	Q99453
PGCSGLGPGGVRGFG	TSEN15	11	Q8WW01
PAAQGPGGGGAGAPG	VASP	211	P50552