Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein tyrosine/serine/threonine phosphatase activity	CDC14C DUSP4 DUSP5 CDC14B	7.61e-05	43	105	4	GO:0008138
GeneOntologyMolecularFunction	G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential	GABRB1 GABBR1	8.19e-05	3	105	2	GO:0150047
GeneOntologyMolecularFunction	IMP 5'-nucleotidase activity	NT5C NT5C1A	1.63e-04	4	105	2	GO:0050483
GeneOntologyMolecularFunction	anandamide 8,9 epoxidase activity	CYP2D7 CYP2D6	1.63e-04	4	105	2	GO:0062187
GeneOntologyMolecularFunction	anandamide 11,12 epoxidase activity	CYP2D7 CYP2D6	1.63e-04	4	105	2	GO:0062188
GeneOntologyMolecularFunction	steroid 21-monooxygenase activity	CYP2D7 CYP2D6	1.63e-04	4	105	2	GO:0004509
GeneOntologyMolecularFunction	progesterone 21-hydroxylase activity	CYP2D7 CYP2D6	1.63e-04	4	105	2	GO:0106309
GeneOntologyMolecularFunction	GABA receptor activity	GABRB1 GABRD GABBR1	2.02e-04	22	105	3	GO:0016917
GeneOntologyMolecularFunction	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	GABRB1 GABRD GRIN2B GABBR1	2.81e-04	60	105	4	GO:0099529
GeneOntologyMolecularFunction	anandamide 14,15 epoxidase activity	CYP2D7 CYP2D6	4.05e-04	6	105	2	GO:0062189
GeneOntologyMolecularFunction	anandamide epoxidase activity	CYP2D7 CYP2D6	4.05e-04	6	105	2	GO:0062186
GeneOntologyMolecularFunction	beta-catenin binding	CDH23 GRIN2B CDH22 CTNNA1 CDH18	4.31e-04	120	105	5	GO:0008013
GeneOntologyMolecularFunction	channel activity	GABRB1 GABRD GJD2 KCNV2 PKD2L1 GJC2 GRIN2B P2RX4 APOL4 UNC80	4.48e-04	525	105	10	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	GABRB1 GABRD GJD2 KCNV2 PKD2L1 GJC2 GRIN2B P2RX4 APOL4 UNC80	4.54e-04	526	105	10	GO:0022803
GeneOntologyMolecularFunction	postsynaptic neurotransmitter receptor activity	GABRB1 GABRD GRIN2B GABBR1	6.59e-04	75	105	4	GO:0098960
GeneOntologyMolecularFunction	extracellular ligand-gated monoatomic ion channel activity	GABRB1 GABRD GRIN2B P2RX4	7.28e-04	77	105	4	GO:0005230
GeneOntologyMolecularFunction	phosphatase activity	CDC14C DUSP4 DUSP5 CDC14B NT5C NT5C1A MTM1	8.08e-04	287	105	7	GO:0016791
GeneOntologyMolecularFunction	myosin phosphatase activity	CDC14C DUSP4 DUSP5 CDC14B	1.05e-03	85	105	4	GO:0017018
GeneOntologyMolecularFunction	MAP kinase tyrosine phosphatase activity	DUSP4 DUSP5	1.20e-03	10	105	2	GO:0033550
GeneOntologyMolecularFunction	protein tyrosine/threonine phosphatase activity	DUSP4 DUSP5	1.46e-03	11	105	2	GO:0008330
GeneOntologyMolecularFunction	neurotransmitter receptor activity	GABRB1 GABRD GRIN2B GABBR1	1.92e-03	100	105	4	GO:0030594
GeneOntologyMolecularFunction	calcium ion binding	CAPN9 DCHS2 FAT3 PCDHB13 PCDHB12 RCN2 CDH23 PKD2L1 PLA2G4D CDH22 CDH18	1.95e-03	749	105	11	GO:0005509
GeneOntologyMolecularFunction	G protein-coupled neurotransmitter receptor activity	GABRB1 GABBR1	2.06e-03	13	105	2	GO:0099528
GeneOntologyMolecularFunction	MAP kinase tyrosine/serine/threonine phosphatase activity	DUSP4 DUSP5	2.06e-03	13	105	2	GO:0017017
GeneOntologyMolecularFunction	cadherin binding	PKP4 CDH23 CDH22 P2RX4 PI4KA CTNNA1 CDH18	2.10e-03	339	105	7	GO:0045296
GeneOntologyMolecularFunction	protein tyrosine phosphatase activity	CDC14C DUSP4 DUSP5 CDC14B	2.14e-03	103	105	4	GO:0004725
GeneOntologyMolecularFunction	protein serine/threonine phosphatase activity	CDC14C DUSP4 DUSP5 CDC14B	2.63e-03	109	105	4	GO:0004722
GeneOntologyMolecularFunction	5'-nucleotidase activity	NT5C NT5C1A	2.75e-03	15	105	2	GO:0008253
GeneOntologyMolecularFunction	monoatomic ion channel activity	GABRB1 GABRD KCNV2 PKD2L1 GRIN2B P2RX4 APOL4 UNC80	2.93e-03	459	105	8	GO:0005216
GeneOntologyMolecularFunction	phosphoprotein phosphatase activity	CDC14C DUSP4 DUSP5 CDC14B MTM1	3.24e-03	189	105	5	GO:0004721
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	GABRB1 GABRD GRIN2B	3.36e-03	57	105	3	GO:1904315
GeneOntologyMolecularFunction	hydrolase activity, acting on ester bonds	CDC14C XRN2 DUSP4 DUSP5 ACOT1 PLA2G4D CDC14B NT5C NT5C1A MTM1 PGBD5	3.46e-03	807	105	11	GO:0016788
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	GABRB1 GABRD PKD2L1 GRIN2B P2RX4	3.55e-03	193	105	5	GO:0015276
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	DOHH CYP2D7 CYP2D6 KDM3B P3H2	3.62e-03	194	105	5	GO:0016705
GeneOntologyMolecularFunction	ligand-gated channel activity	GABRB1 GABRD PKD2L1 GRIN2B P2RX4	3.87e-03	197	105	5	GO:0022834
GeneOntologyMolecularFunction	nucleotidase activity	NT5C NT5C1A	3.97e-03	18	105	2	GO:0008252
GeneOntologyMolecularFunction	MAP kinase phosphatase activity	DUSP4 DUSP5	3.97e-03	18	105	2	GO:0033549
GeneOntologyMolecularFunction	phosphoric ester hydrolase activity	CDC14C DUSP4 DUSP5 CDC14B NT5C NT5C1A MTM1	4.30e-03	386	105	7	GO:0042578
GeneOntologyMolecularFunction	cell adhesion molecule binding	PKP4 CDH23 GRIN2B CDH22 P2RX4 ICAM5 PI4KA CTNNA1 CDH18	4.33e-03	599	105	9	GO:0050839
GeneOntologyMolecularFunction	GABA-A receptor activity	GABRB1 GABRD	4.42e-03	19	105	2	GO:0004890
GeneOntologyMolecularFunction	GTPase activating protein binding	ARHGAP35 PLXNB1	4.42e-03	19	105	2	GO:0032794
GeneOntologyMolecularFunction	transmitter-gated channel activity	GABRB1 GABRD GRIN2B	4.87e-03	65	105	3	GO:0022835
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity	GABRB1 GABRD GRIN2B	4.87e-03	65	105	3	GO:0022824
GeneOntologyMolecularFunction	proteasome binding	USP13 ECPAS	4.89e-03	20	105	2	GO:0070628
GeneOntologyMolecularFunction	peroxisome proliferator activated receptor binding	NCOA3 NCOR1	5.39e-03	21	105	2	GO:0042975
GeneOntologyCellularComponent	catenin complex	CDH23 CDH22 CTNNA1 CDH18	1.87e-05	32	104	4	GO:0016342
GeneOntologyCellularComponent	GABA receptor complex	GABRB1 GABRD GABBR1	1.49e-04	21	104	3	GO:1902710
GeneOntologyCellularComponent	anchoring junction	DCHS2 TRIM15 GJD2 PKP4 NOX4 GJC2 DES CDH22 PIK3R2 PI4KA CSPG4 KAZN CTNNA1 CDH18	3.38e-04	976	104	14	GO:0070161
MousePheno	abnormal learning/memory/conditioning	GABRB1 CDC14C GABRD CHST5 RELCH GJD2 KDM3B CDH23 GJC2 ACOT1 NDN GRIN2B CDC14B OPA1 NCOR1 THOP1 LZTS1 ICAM5 AUTS2 UNC80 PGBD5 GABBR1 CDH18 CA8	5.09e-07	1239	89	24	MP:0002063
MousePheno	abnormal cognition	GABRB1 CDC14C GABRD CHST5 RELCH GJD2 KDM3B CDH23 GJC2 ACOT1 NDN GRIN2B CDC14B OPA1 NCOR1 THOP1 LZTS1 ICAM5 AUTS2 UNC80 PGBD5 GABBR1 CDH18 CA8	5.64e-07	1246	89	24	MP:0014114
Domain	Cadherin_CS	DCHS2 FAT3 PCDHB13 PCDHB12 CDH23 CDH22 CDH18	2.08e-06	109	101	7	IPR020894
Domain	CADHERIN_1	DCHS2 FAT3 PCDHB13 PCDHB12 CDH23 CDH22 CDH18	2.65e-06	113	101	7	PS00232
Domain	Cadherin	DCHS2 FAT3 PCDHB13 PCDHB12 CDH23 CDH22 CDH18	2.65e-06	113	101	7	PF00028
Domain	CADHERIN_2	DCHS2 FAT3 PCDHB13 PCDHB12 CDH23 CDH22 CDH18	2.81e-06	114	101	7	PS50268
Domain	-	DCHS2 FAT3 PCDHB13 PCDHB12 CDH23 CDH22 CDH18	2.81e-06	114	101	7	2.60.40.60
Domain	CA	DCHS2 FAT3 PCDHB13 PCDHB12 CDH23 CDH22 CDH18	2.98e-06	115	101	7	SM00112
Domain	Cadherin-like	DCHS2 FAT3 PCDHB13 PCDHB12 CDH23 CDH22 CDH18	3.16e-06	116	101	7	IPR015919
Domain	Cadherin	DCHS2 FAT3 PCDHB13 PCDHB12 CDH23 CDH22 CDH18	3.54e-06	118	101	7	IPR002126
Domain	HEAT_type_2	RELCH DOHH DNAAF5	9.88e-05	17	101	3	IPR021133
Domain	PTPc_motif	DUSP4 DUSP5 CDC14B MTM1	2.92e-04	59	101	4	SM00404
Domain	Tyr_Pase_cat	DUSP4 DUSP5 CDC14B MTM1	2.92e-04	59	101	4	IPR003595
Domain	HEAT_REPEAT	RELCH DOHH ECPAS DNAAF5	5.62e-04	70	101	4	PS50077
Domain	Filament_head	DES NEFL	5.97e-04	7	101	2	PF04732
Domain	CULLIN	CUL3 ANAPC2	5.97e-04	7	101	2	SM00182
Domain	Intermed_filament_DNA-bd	DES NEFL	5.97e-04	7	101	2	IPR006821
Domain	Tyr_Pase_AS	DUSP4 DUSP5 CDC14B MTM1	6.59e-04	73	101	4	IPR016130
Domain	TYR_PHOSPHATASE_DUAL	DUSP4 DUSP5 CDC14B	8.13e-04	34	101	3	PS50054
Domain	TYR_PHOSPHATASE_DUAL_dom	DUSP4 DUSP5 CDC14B	8.86e-04	35	101	3	IPR020422
Domain	DSPc	DUSP4 DUSP5 CDC14B	8.86e-04	35	101	3	SM00195
Domain	Cullin_homology	CUL3 ANAPC2	1.02e-03	9	101	2	IPR016158
Domain	TYR_PHOSPHATASE_1	DUSP4 DUSP5 CDC14B MTM1	1.22e-03	86	101	4	PS00383
Domain	MKP	DUSP4 DUSP5	1.27e-03	10	101	2	IPR008343
Domain	Cullin	CUL3 ANAPC2	1.27e-03	10	101	2	PF00888
Domain	CULLIN_2	CUL3 ANAPC2	1.27e-03	10	101	2	PS50069
Domain	Cullin_N	CUL3 ANAPC2	1.27e-03	10	101	2	IPR001373
Domain	CULLIN_1	CUL3 ANAPC2	1.27e-03	10	101	2	PS01256
Domain	TYR_PHOSPHATASE_2	DUSP4 DUSP5 CDC14B MTM1	1.27e-03	87	101	4	PS50056
Domain	TYR_PHOSPHATASE_dom	DUSP4 DUSP5 CDC14B MTM1	1.27e-03	87	101	4	IPR000387
Domain	-	RELCH DOHH PKP4 PSMD2 ECPAS DNAAF5	1.31e-03	222	101	6	1.25.10.10
Domain	Rho_GTPase_activation_prot	ARHGAP35 PIK3R2 PLXNB1 ARAP1	1.33e-03	88	101	4	IPR008936
Domain	Dual-sp_phosphatase_cat-dom	DUSP4 DUSP5 CDC14B	1.41e-03	41	101	3	IPR000340
Domain	DSPc	DUSP4 DUSP5 CDC14B	1.41e-03	41	101	3	PF00782
Domain	-	DUSP4 DUSP5 CDC14B MTM1	1.56e-03	92	101	4	3.90.190.10
Domain	Prot-tyrosine_phosphatase-like	DUSP4 DUSP5 CDC14B MTM1	2.05e-03	99	101	4	IPR029021
Domain	ARM-type_fold	RELCH DOHH PKP4 PSMD2 ECPAS DNAAF5 PI4KA	2.44e-03	339	101	7	IPR016024
Domain	ARM-like	RELCH DOHH PKP4 PSMD2 ECPAS DNAAF5	3.48e-03	270	101	6	IPR011989
Domain	HEAT	DOHH ECPAS DNAAF5	3.82e-03	58	101	3	IPR000357
Domain	RhoGAP	ARHGAP35 PIK3R2 ARAP1	4.61e-03	62	101	3	SM00324
Domain	CONNEXINS_1	GJD2 GJC2	4.66e-03	19	101	2	PS00407
Domain	RhoGAP	ARHGAP35 PIK3R2 ARAP1	4.82e-03	63	101	3	PF00620
Domain	RHOGAP	ARHGAP35 PIK3R2 ARAP1	5.04e-03	64	101	3	PS50238
Domain	RhoGAP_dom	ARHGAP35 PIK3R2 ARAP1	5.04e-03	64	101	3	IPR000198
Domain	-	ARHGAP35 PIK3R2 ARAP1	5.04e-03	64	101	3	1.10.555.10
Domain	CONNEXINS_2	GJD2 GJC2	5.16e-03	20	101	2	PS00408
Domain	Connexin	GJD2 GJC2	5.16e-03	20	101	2	IPR000500
Domain	Connexin_CCC	GJD2 GJC2	5.16e-03	20	101	2	IPR019570
Domain	Connexin_N	GJD2 GJC2	5.16e-03	20	101	2	IPR013092
Domain	Connexin	GJD2 GJC2	5.16e-03	20	101	2	PF00029
Domain	Connexin_CCC	GJD2 GJC2	5.16e-03	20	101	2	SM01089
Domain	Connexin_CS	GJD2 GJC2	5.16e-03	20	101	2	IPR017990
Domain	CNX	GJD2 GJC2	5.16e-03	20	101	2	SM00037
Domain	RHOD	DUSP4 DUSP5	6.23e-03	22	101	2	SM00450
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	RELCH RBM15 BCAS2 PKP4 DUSP4 DUSP5 RCN2 KRI1 PSMD2 CLPX CDC14B OPA1 NEFL NCOR1 PI4KA MTM1 CTNNA1	1.69e-08	1049	105	17	27880917
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	CUL3 USP13 XRN2 PKP4 KDM3B GON4L CLPX ARHGEF40 ANAPC2 CDK5RAP1 PLXNB1	4.54e-06	650	105	11	38777146
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	CUL3 RBM15 XRN2 AICDA RCN2 KRI1 BAZ1B PSMD2 CLPX ECPAS OPA1	4.75e-06	653	105	11	33742100
Pubmed	Comprehensive identification of phosphorylation sites in postsynaptic density preparations.	PKP4 GJC2 GRIN2B ARHGAP35 NEFL PRICKLE2 GABBR1	6.82e-06	231	105	7	16452087
Pubmed	Overexpression of CDC14B causes mitotic arrest and inhibits zygotic genome activation in mouse preimplantation embryos.	CDC14C CDC14B	9.03e-06	2	105	2	19923902
Pubmed	The Cdc14B phosphatase displays oncogenic activity mediated by the Ras-Mek signaling pathway.	CDC14C CDC14B	9.03e-06	2	105	2	21502810
Pubmed	Molecular evolution of the CYP2D subfamily in primates: purifying selection on substrate recognition sites without the frequent or long-tract gene conversion.	CYP2D7 CYP2D6	9.03e-06	2	105	2	25808902
Pubmed	Polymorphisms in CYP2D6 duplication-negative individuals with the ultrarapid metabolizer phenotype: a role for the CYP2D6*35 allele in ultrarapid metabolism?	CYP2D7 CYP2D6	9.03e-06	2	105	2	11207030
Pubmed	Birth and rapid subcellular adaptation of a hominoid-specific CDC14 protein.	CDC14C CDC14B	9.03e-06	2	105	2	18547142
Pubmed	Characterization of the common genetic defect in humans deficient in debrisoquine metabolism.	CYP2D7 CYP2D6	9.03e-06	2	105	2	3123997
Pubmed	Epilepsy, hyperalgesia, impaired memory, and loss of pre- and postsynaptic GABA(B) responses in mice lacking GABA(B(1)).	GABRB1 GABBR1	9.03e-06	2	105	2	11498050
Pubmed	Cullin 3 mediates SRC-3 ubiquitination and degradation to control the retinoic acid response.	CUL3 NCOA3	9.03e-06	2	105	2	22147914
Pubmed	Differential roles of GABAB1 subunit isoforms on locomotor responses to acute and repeated administration of cocaine.	GABRB1 GABBR1	9.03e-06	2	105	2	26518330
Pubmed	Direct interactions between corepressors and coactivators permit the integration of nuclear receptor-mediated repression and activation.	NCOA3 NCOR1	9.03e-06	2	105	2	12089344
Pubmed	Structure and expression of the mouse necdin gene. Identification of a postmitotic neuron-restrictive core promoter.	NDN NEFL	9.03e-06	2	105	2	8557705
Pubmed	Characterization of Cyp2d22, a novel cytochrome P450 expressed in mouse mammary cells.	CYP2D7 CYP2D6	9.03e-06	2	105	2	11032406
Pubmed	Myotubularin controls desmin intermediate filament architecture and mitochondrial dynamics in human and mouse skeletal muscle.	DES MTM1	9.03e-06	2	105	2	21135508
Pubmed	Silencing of spontaneous activity at α4β1/3δ GABAA receptors in hippocampal granule cells reveals different ligand pharmacology.	GABRB1 GABRD	9.03e-06	2	105	2	32484592
Pubmed	The expression of CYP2D22, an ortholog of human CYP2D6, in mouse striatum and its modulation in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype and nicotine-mediated neuroprotection.	CYP2D7 CYP2D6	9.03e-06	2	105	2	19594327
Pubmed	Coding-noncoding gene expression in intrahepatic cholangiocarcinoma.	CYP2D7 CYP2D6	9.03e-06	2	105	2	26297049
Pubmed	A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine.	CYP2D7 CYP2D6	9.03e-06	2	105	2	15051713
Pubmed	Lack of GABAB receptors modifies behavioural and biochemical alterations induced by precipitated nicotine withdrawal.	GABRB1 GABBR1	9.03e-06	2	105	2	25479464
Pubmed	GABA(B) receptor 1 polymorphism (G1465A) is associated with temporal lobe epilepsy.	GABRB1 GABBR1	9.03e-06	2	105	2	12601092
Pubmed	GABA neurotransmitter signaling in the developing mouse lens: dynamic regulation of components and functionality.	GABRB1 GABRD GABBR1	2.11e-05	18	105	3	18985723
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	RBM15 XRN2 PKP4 ARHGAP35 CLPX ECPAS NEFL ARHGEF40 PIK3R2 KAZN CTNNA1 ARAP1	2.15e-05	916	105	12	32203420
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	CUL3 NCOA3 RBM15 XRN2 HIRIP3 KDM3B BAZ1B ARHGAP35 ECPAS NCOR1 CTNNA1	2.31e-05	774	105	11	15302935
Pubmed	Early-onset aging and defective DNA damage response in Cdc14b-deficient mice.	CDC14C CDC14B	2.70e-05	3	105	2	21262768
Pubmed	Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription.	CDC14C CDC14B	2.70e-05	3	105	2	22355704
Pubmed	Mutations in the calcium-binding motifs of CDH23 and the 35delG mutation in GJB2 cause hearing loss in one family.	GJD2 CDH23	2.70e-05	3	105	2	12522556
Pubmed	Involvement of Brain-Enriched Guanylate Kinase-Associated Protein (BEGAIN) in Chronic Pain after Peripheral Nerve Injury.	GRIN2B ICAM5	2.70e-05	3	105	2	27785460
Pubmed	High-Throughput Sequencing Identifies 3 Novel Susceptibility Genes for Hereditary Melanoma.	CDH23 ARHGEF40	2.70e-05	3	105	2	32276436
Pubmed	The E3 ubiquitin ligase Asb2β is downregulated in a mouse model of hypertrophic cardiomyopathy and targets desmin for proteasomal degradation.	DES ASB2	2.70e-05	3	105	2	26343497
Pubmed	The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.	CYP2D7 CYP2D6	2.70e-05	3	105	2	2574001
Pubmed	Impaired bidirectional communication between interneurons and oligodendrocyte precursor cells affects social cognitive behavior.	CSPG4 GABBR1	2.70e-05	3	105	2	35296664
Pubmed	CDC14B acts through FZR1 (CDH1) to prevent meiotic maturation of mouse oocytes.	CDC14C CDC14B	2.70e-05	3	105	2	19129509
Pubmed	Cdc14A and Cdc14B Redundantly Regulate DNA Double-Strand Break Repair.	CDC14C CDC14B	2.70e-05	3	105	2	26283732
Pubmed	Identification of the primary gene defect at the cytochrome P450 CYP2D locus.	CYP2D7 CYP2D6	2.70e-05	3	105	2	1978251
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CUL3 RELCH KDM3B AKNA ECPAS ANAPC2 AUTS2 PLXNB1 ARAP1	3.36e-05	529	105	9	14621295
Pubmed	Early growth response 1 (Egr-1) directly regulates GABAA receptor α2, α4, and θ subunits in the hippocampus.	GABRB1 GABRD GRIN2B	3.42e-05	21	105	3	25708312
Pubmed	Phosphorylation-dependent interaction of the N-methyl-D-aspartate receptor epsilon 2 subunit with phosphatidylinositol 3-kinase.	GRIN2B PIK3R2	5.40e-05	4	105	2	10620012
Pubmed	Grb2 mediates semaphorin-4D-dependent RhoA inactivation.	ARHGAP35 PLXNB1	5.40e-05	4	105	2	22505611
Pubmed	Gigaxonin glycosylation regulates intermediate filament turnover and may impact giant axonal neuropathy etiology or treatment.	CUL3 NEFL	5.40e-05	4	105	2	31944090
Pubmed	Mis12 controls cyclin B1 stabilization via Cdc14B-mediated APC/CCdh1 regulation during meiotic G2/M transition in mouse oocytes.	CDC14C CDC14B	5.40e-05	4	105	2	32341029
Pubmed	Planar cell polarity-dependent asymmetric organization of microtubules for polarized positioning of the basal body in node cells.	DCHS2 PRICKLE2	5.40e-05	4	105	2	35420656
Pubmed	CDC14A phosphatase is essential for hearing and male fertility in mouse and human.	CDC14C CDC14B	5.40e-05	4	105	2	29293958
Pubmed	Positive regulation by γ-aminobutyric acid B receptor subunit-1 of chondrogenesis through acceleration of nuclear translocation of activating transcription factor-4.	GABRB1 GABBR1	5.40e-05	4	105	2	22879594
Pubmed	Regulation of angiopoietin-1/Tie-2 receptor signaling in endothelial cells by dual-specificity phosphatases 1, 4, and 5.	DUSP4 DUSP5	5.40e-05	4	105	2	24308939
Pubmed	Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control.	USP13 PSMD2	5.40e-05	4	105	2	21571647
Pubmed	Nuclear receptor coregulator SNP discovery and impact on breast cancer risk.	NCOA3 NCOR1	5.40e-05	4	105	2	20003447
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	RBM15 XRN2 FAT3 KRI1 GON4L SLC4A5	8.04e-05	234	105	6	36243803
Pubmed	The endothelial transcription factor ERG promotes vascular stability and growth through Wnt/β-catenin signaling.	DES CSPG4	8.97e-05	5	105	2	25584796
Pubmed	Coactivator and corepressor gene expression in rat cerebellum during postnatal development and the effect of altered thyroid status.	NCOA3 NCOR1	8.97e-05	5	105	2	10803578
Pubmed	Pericyte dynamics in the mouse germinal matrix angiogenesis.	DES CSPG4	8.97e-05	5	105	2	35506590
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	CUL3 TRIM15 RBM15 HIRIP3 BCAS2 BAZ1B PSMD2 ECPAS PI4KA PRICKLE2	9.79e-05	754	105	10	35906200
Pubmed	Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.	GABRB1 GABRD GRIN2B GABBR1	1.09e-04	81	105	4	22723691
Pubmed	A protein interaction landscape of breast cancer.	XRN2 PKP4 FADD CLPX ECPAS DNAAF5 PIK3R2 PI4KA CTNNA1	1.34e-04	634	105	9	34591612
Pubmed	A novel partial agonist of peroxisome proliferator-activated receptor-gamma (PPARgamma) recruits PPARgamma-coactivator-1alpha, prevents triglyceride accumulation, and potentiates insulin signaling in vitro.	NCOA3 NCOR1	1.34e-04	6	105	2	16373399
Pubmed	Armc8 is an evolutionarily conserved armadillo protein involved in cell-cell adhesion complexes through multiple molecular interactions.	PKP4 CTNNA1	1.34e-04	6	105	2	30482882
Pubmed	Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation.	NCOR1 CSPG4	1.34e-04	6	105	2	18829436
Pubmed	Heterogeneity in gene loci associated with type 2 diabetes on human chromosome 20q13.1.	SLC13A3 CDH22	1.34e-04	6	105	2	18602983
Pubmed	Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A.	CUL3 AICDA	1.34e-04	6	105	2	26320660
Pubmed	Polymorphism of metabolic genes and susceptibility to occupational chronic manganism.	CYP2D7 CYP2D6	1.34e-04	6	105	2	12171760
Pubmed	Klhl6 Deficiency Impairs Transitional B Cell Survival and Differentiation.	CUL3 AICDA	1.34e-04	6	105	2	28807996
Pubmed	Amygdala gene expression of NMDA and GABA(A) receptors in patients with mesial temporal lobe epilepsy.	GABRB1 GRIN2B	1.34e-04	6	105	2	20848605
Pubmed	The role of Cullin3-mediated ubiquitination of the catalytic subunit of PP2A in TRAIL signaling.	CUL3 FADD	1.34e-04	6	105	2	25551360
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CUL3 NCOA3 PKP4 GRIN2B OPA1 NEFL NCOR1 LZTS1 ICAM5 PI4KA CTNNA1	1.62e-04	963	105	11	28671696
Pubmed	Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.	DCHS2 GRIN2B AUTS2 SLC4A5	1.71e-04	91	105	4	22610502
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	NCOA3 RBM15 XRN2 BCAS2 RCN2 KRI1 BAZ1B PSMD2 CLPX ANAPC2 CDH18	1.74e-04	971	105	11	33306668
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	DUSP4 DUSP5 RCN2 KRI1 PSMD2 ECPAS OPA1 DNAAF5 THOP1 MTM1 CTNNA1	1.78e-04	974	105	11	28675297
Pubmed	Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila.	DCHS2 FAT3	1.88e-04	7	105	2	16059920
Pubmed	S1P1 inhibits sprouting angiogenesis during vascular development.	DES CSPG4	1.88e-04	7	105	2	22951644
Pubmed	HIV gp120- and methamphetamine-mediated oxidative stress induces astrocyte apoptosis via cytochrome P450 2E1.	CYP2D6 NOX4	1.88e-04	7	105	2	24113184
Pubmed	The GTPase-deficient Rnd proteins are stabilized by their effectors.	ARHGAP35 PLXNB1	1.88e-04	7	105	2	22807448
Pubmed	Associations and interactions between Ets-1 and Ets-2 and coregulatory proteins, SRC-1, AIB1, and NCoR in breast cancer.	NCOA3 NCOR1	1.88e-04	7	105	2	15788656
Pubmed	Effects of infection of MRSA on the expression and activity of renal cytochrome P450s in mice.	CYP2D7 CYP2D6	1.88e-04	7	105	2	30944282
Pubmed	Involvement of the Reck tumor suppressor protein in maternal and embryonic vascular remodeling in mice.	DES CSPG4	1.88e-04	7	105	2	20691046
Pubmed	The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map.	FAT3 DUSP4 NEFL AUTS2	1.94e-04	94	105	4	23431145
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	CUL3 PKP4 GRIN2B OPA1 NEFL PI4KA	2.17e-04	281	105	6	28706196
Pubmed	p190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin signalling.	ARHGAP35 PLXNB1	2.50e-04	8	105	2	16188938
Pubmed	The quest for juvenile myoclonic epilepsy genes.	GABRD GJD2	2.50e-04	8	105	2	23756480
Pubmed	Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept.	GABRB1 AUTS2	2.50e-04	8	105	2	19567891
Pubmed	Expression of catenins during mouse embryonic development and in adult tissues.	NEFL CTNNA1	3.21e-04	9	105	2	8821035
Pubmed	Superresolution imaging of chemical synapses in the brain.	GRIN2B GABBR1	3.21e-04	9	105	2	21144999
Pubmed	TRAF2 Sets a threshold for extrinsic apoptosis by tagging caspase-8 with a ubiquitin shutoff timer.	CUL3 FADD	3.21e-04	9	105	2	23142077
Pubmed	Msx1 is expressed in retina endothelial cells at artery branching sites.	DES CSPG4	3.21e-04	9	105	2	23213427
Pubmed	Perlecan maintains microvessel integrity in vivo and modulates their formation in vitro.	DES CSPG4	3.21e-04	9	105	2	23320101
Pubmed	Genome-wide association study of smoking initiation and current smoking.	CDH23 GRIN2B	3.21e-04	9	105	2	19268276
Pubmed	A CNS-specific hypomorphic Pdgfr-beta mutant model of diabetic retinopathy.	DES CSPG4	3.21e-04	9	105	2	23633653
Pubmed	Dysmorphogenesis of kidney cortical peritubular capillaries in angiopoietin-2-deficient mice.	DES CSPG4	3.21e-04	9	105	2	15579434
Pubmed	BDNF+/- mice exhibit deficits in oligodendrocyte lineage cells of the basal forebrain.	NEFL CSPG4	3.21e-04	9	105	2	20091777
Pubmed	Role of the Wilms' tumor suppressor gene Wt1 in pancreatic development.	DES CSPG4	3.21e-04	9	105	2	29708625
Pubmed	Nestin mRNA expression correlates with the central nervous system progenitor cell state in many, but not all, regions of developing central nervous system.	DES NEFL	3.21e-04	9	105	2	7720210
Pubmed	Biological insights from 108 schizophrenia-associated genetic loci.	CUL3 CYP2D6 HIRIP3 KDM3B CTNNA1 CA8	3.25e-04	303	105	6	25056061
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	CUL3 PKP4 PSMD2 GJC2 GRIN2B ARHGAP35 OPA1 NEFL LZTS1 ICAM5 PI4KA PRICKLE2 CTNNA1	3.81e-04	1431	105	13	37142655
Pubmed	Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1.	CUL3 NCOA3	4.00e-04	10	105	2	21577200
Pubmed	Enhancer activation requires trans-recruitment of a mega transcription factor complex.	NCOA3 NCOR1	4.00e-04	10	105	2	25303530
Pubmed	Single-neuron diversity generated by Protocadherin-β cluster in mouse central and peripheral nervous systems.	PCDHB13 PCDHB12	4.00e-04	10	105	2	22969705
Pubmed	Transcriptional cofactors exhibit differential preference toward peroxisome proliferator-activated receptors alpha and delta in uterine cells.	NCOA3 NCOR1	4.00e-04	10	105	2	15001550
Pubmed	Adhesion molecule CADM1 contributes to gap junctional communication among pancreatic islet α-cells and prevents their excessive secretion of glucagon.	GJD2 GJC2	4.00e-04	10	105	2	22513384
Pubmed	Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss.	DUSP4 DUSP5 NOX4	4.19e-04	48	105	3	30938680
GeneFamily	Cadherin related	DCHS2 FAT3 CDH23	3.96e-05	17	72	3	24
GeneFamily	CD molecules\|5'-nucleotidases	NT5C NT5C1A	3.24e-04	7	72	2	1042
GeneFamily	MAP kinase phosphatases	DUSP4 DUSP5	8.40e-04	11	72	2	895
GeneFamily	CD molecules\|Type II classical cadherins	CDH22 CDH18	1.19e-03	13	72	2	1186
GeneFamily	Gamma-aminobutyric acid type A receptor subunits	GABRB1 GABRD	2.56e-03	19	72	2	563
GeneFamily	CD molecules\|Mucins	MUC15 MUC16	3.13e-03	21	72	2	648
GeneFamily	Gap junction proteins	GJD2 GJC2	3.43e-03	22	72	2	314
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHST5 DUSP4 NDN DES CSPG4 KAZN PLXNB1	2.57e-07	182	105	7	9edaccf1154cec92ca9a28e9b1f9075cfd422bfd
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHST5 DUSP4 NDN DES CSPG4 KAZN PLXNB1	2.57e-07	182	105	7	aba4c06d5d7618ac21b2695bca8e7a1346a91090
ToppCell	E17.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_myogenic_precursor_(Axin2+)\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	DUSP5 NOX4 NDN CDC14B DES CSPG4 KAZN	3.32e-07	189	105	7	26cfe5b7e7f477f225f4e9f25f983f432f01e183
ToppCell	Hippocampus-Neuronal-Excitatory\|Hippocampus / BrainAtlas - Mouse McCarroll V32	GABRB1 FAT3 DUSP5 NEFL LZTS1 ICAM5 PRICKLE2	3.32e-07	189	105	7	4b90d181eb0a42814eeb23bc82e52fd3a12392a7
ToppCell	droplet-Lung-1m-Mesenchymal-myofibroblast-pericyte_cell-pericyte\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CHST5 DUSP4 NDN DES CSPG4 PLXNB1	4.96e-06	184	105	6	4cb5f299dd7413e0be1ad7af817ee614b23a18ae
ToppCell	droplet-Lung-1m-Mesenchymal-myofibroblast-pericyte_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CHST5 DUSP4 NDN DES CSPG4 PLXNB1	4.96e-06	184	105	6	39bb0eb55bdc2cea46e41c7f21d8c5883f14e6bd
ToppCell	E17.5-Mesenchymal-developing_mesenchymal_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	NOX4 NDN CDC14B DES CSPG4 KAZN	5.96e-06	190	105	6	2ab604d35456beba71c25511e0f819000e6642d2
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_neuro-secretory\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	GABRB1 FAT3 MUC16 PKD2L1 CDH22 UNC80	6.72e-06	194	105	6	2dcc3b99dbedaf8a6916891c85091ddb79d7ee31
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Rectal_Adenocarcinoma-5\|TCGA-Colorectal / Sample_Type by Project: Shred V9	CAPN9 CHST5 MUC15 PLA2G4D CA8	1.18e-05	125	105	5	c82b4bddc98b2a2d2ee00c1392df86f9735c0623
ToppCell	Frontal_cortex-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	CAPN9 CHST5 IL25 IFI44L	2.28e-05	70	105	4	986c7a1002a4ffd3a246495bedde2997ffdc2c9d
ToppCell	Frontal_cortex-Macroglia-POLYDENDROCYTE-P3-Tnr\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	CAPN9 CHST5 IL25 IFI44L	2.28e-05	70	105	4	c0330216305491d7d57cdbea0ae3cb8e9092c8e3
ToppCell	Frontal_cortex-Macroglia-POLYDENDROCYTE-P3\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	CAPN9 CHST5 IL25 IFI44L	2.28e-05	70	105	4	86dde790fcdaec2095e2256463953077811145d2
ToppCell	Frontal_cortex-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	CAPN9 CHST5 IL25 IFI44L	2.28e-05	70	105	4	e604660b2efbc03e21806dcaecf7a72321673ae2
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Colon_Adenocarcinoma-5\|TCGA-Colorectal / Sample_Type by Project: Shred V9	CAPN9 CHST5 DUSP4 SHF CA8	3.54e-05	157	105	5	5fb41af247465aa29aa7b8edd26e3d3794766f80
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	DUSP5 NEFL CDH22 LZTS1 ICAM5	3.99e-05	161	105	5	ba7ce599b173cf81c8323e7c96dc3d57379f1ed6
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	DUSP5 NEFL LZTS1 ICAM5 CDH18	4.23e-05	163	105	5	218b9ba099cb27aa91c6b73bf89b44895f5dddc3
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	GABRB1 DUSP5 NEFL ICAM5 PRICKLE2	4.88e-05	168	105	5	6db453cbbbaf4144a86fadcfa5805d33396713b5
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DUSP5 NDN DES P3H2 CSPG4	5.17e-05	170	105	5	1f994b690e881106a5d54b3080ccce6260bc3ac5
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DCHS2 FAT3 LZTS1 CSPG4 GABBR1	5.17e-05	170	105	5	5570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCell	Bronchial_Biopsy-Endothelial-Lymphatic\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	PCDHB12 NOX4 GJC2 GRIN2B P3H2	5.46e-05	172	105	5	c41f5a66781bbf63afce7ca5d118cc6d8e0fe0bc
ToppCell	facs-Lung-EPCAM-3m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHST5 DUSP4 DES CSPG4 KAZN	5.61e-05	173	105	5	3059325901b1e5e12a1a91183f14267288b2f600
ToppCell	facs-Lung-EPCAM-3m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHST5 DUSP4 DES CSPG4 KAZN	5.61e-05	173	105	5	36c8338463ee4cc432f568728d55989360f9a68d
ToppCell	facs-Heart-LV-24m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT3 DUSP4 DES ASB2 PLXNB1	5.77e-05	174	105	5	197686570cec6d96a92e77e6409325d3bfe6f991
ToppCell	facs-Heart-LV-24m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT3 DUSP4 DES ASB2 PLXNB1	5.77e-05	174	105	5	2eee7b5471672b439f95eba11494c2adf8cb7006
ToppCell	facs-Trachea-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l39\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	AICDA DES P3H2 CSPG4 ASB2	6.26e-05	177	105	5	928118b0ed120ec01c7d753ce523ab609ac24e5f
ToppCell	facs-Lung-18m-Mesenchymal-myofibroblast-pericyte_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CHST5 DUSP4 DES CSPG4 PLXNB1	6.43e-05	178	105	5	8bae5db100f4563aa1fc7f881e7f8c59d669e37a
ToppCell	facs-Lung-18m-Mesenchymal-myofibroblast-pericyte_cell-pericyte\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CHST5 DUSP4 DES CSPG4 PLXNB1	6.43e-05	178	105	5	bc0336692b84bd0fa49747ed5a031b8ed8afa0fd
ToppCell	tumor_Lymph_Node_/_Brain-Myeloid_cells-Activated_DCs\|Myeloid_cells / Location, Cell class and cell subclass	DUSP4 DUSP5 ICAM5 AUTS2 LONRF2	6.60e-05	179	105	5	5f7e6670a0e906a0a5bc75735408361d88e78fa2
ToppCell	COVID-19_Convalescent-Classical_Monocyte-cMono_4\|Classical_Monocyte / Disease condition and Cell class	USP13 DUSP5 ARHGAP35 ARHGEF40 IFI44L	6.60e-05	179	105	5	9d51318ac198a8801bd5c7031ebf2b0c74ffeeb6
ToppCell	15-Distal-Epithelial-Neuroendocrine\|Distal / Age, Tissue, Lineage and Cell class	MUC15 PKD2L1 PLA2G4D CHST13 CA8	6.60e-05	179	105	5	bc04789f0fbd293fdcea66acba8cf227af251b7a
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L2-4_RORB_GRIK1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FAT3 NOX4 NEFL CDH22 CDH18	6.77e-05	180	105	5	fd8c2059fcb382ffbfe19e598e37a49e1d5637b5
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FAT3 NOX4 NEFL CDH22 CDH18	6.77e-05	180	105	5	5391d23817f5cc88a0871ddb98968897c839f464
ToppCell	10x5'-bone_marrow-Hematopoietic_Erythro-Mega-Mega-Mast\|bone_marrow / Manually curated celltypes from each tissue	USP13 CYP2D6 NDN PRICKLE2 KAZN	7.71e-05	185	105	5	a62ebaff92f2ed27b27b32c27c89cfbe2cb35116
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	P3H2 AUTS2 KAZN CDH18 CA8	7.91e-05	186	105	5	e83718fabb057100835d3357df407f283d23fe16
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GABRD SHF UNC80 CDH18 CA8	8.53e-05	189	105	5	f57200c93d39c9bce1adba0a6a1c178c028dd86b
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NOX4 NDN DES CSPG4 KAZN	8.53e-05	189	105	5	ca3a04c202afc32aa11d17154066ef7dc6d01405
ToppCell	P03-Mesenchymal-developing_mesenchymal_cell-mesenchymal_myogenic_precursor_(Axin2+)\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	DUSP5 NDN DES CSPG4 KAZN	8.74e-05	190	105	5	979b1476fd2692fde977ce56257315fcfc8a01d5
ToppCell	PCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_neuroendocrine1[NE1]_(11)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	GJD2 CDH22 LONRF2 UNC80 CA8	8.74e-05	190	105	5	b1095b2a7467c152d16e4f19a9515aeb61fc9e3d
ToppCell	Control-Epithelial-Ciliated_cells\|Control / Condition, Lineage and Cell class	MUC15 MUC16 SLC13A3 FAM227A PLXNB1	8.96e-05	191	105	5	ea1d2c6838119b7019e9a2ff71d6212262b51b57
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GABRB1 USP13 PKP4 PRICKLE2 KAZN	8.96e-05	191	105	5	963f4f2e852bbb4faf070aafb0d368297abacd3b
ToppCell	Control-Epithelial\|Control / Condition, Lineage and Cell class	MUC15 MUC16 SLC13A3 FAM227A PLXNB1	8.96e-05	191	105	5	6228302febdb3dffe37dece7062d27ac9ccc6d4b
ToppCell	P03-Mesenchymal-developing_mesenchymal_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	DUSP5 NDN DES CSPG4 KAZN	9.18e-05	192	105	5	063e119c4b58957643908f667e6cfd6f7517fd03
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GABRD NDN SHF UNC80 CDH18	9.41e-05	193	105	5	5fb7808dd971c1cc64c2bd4f8f1de646fb2d77f4
ToppCell	droplet-Lung-3m-Mesenchymal-myofibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CHST5 NDN DES CSPG4 ASB2	9.64e-05	194	105	5	c992e3357f4bf3069f8d697803e5785e49a2ef0a
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_cytotoxic-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ADCK5 AKNA STK11IP NEFL NCOR1	9.87e-05	195	105	5	83c125223e7ca0f08a31414b3a16347912564765
ToppCell	10x5'-Liver-Lymphocytic_T_CD4/8-lo\|Liver / Manually curated celltypes from each tissue	DUSP4 DUSP5 AKNA DNAAF2 AUTS2	9.87e-05	195	105	5	c29c4ae95a756e3ced0f0747bbfe343590e5b8ab
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT3 GRIN2B LZTS1 ICAM5 UNC80	9.87e-05	195	105	5	ffbab350e67d9c4b66c0ab84550daec8b8139a27
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_neuro-secretory-Ionocyte_n_Brush\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DOHH FAT3 PKD2L1 NT5C1A CDH22	1.01e-04	196	105	5	ef650ff106a76c1e926e13c7f002fbc452cc48ae
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Hematopoietic-Megakaryocytic-Megakaryocyte-Mega\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	MUC16 NDN DES CSPG4 PLXNB1	1.06e-04	198	105	5	5cfd1c030c0940136a397b5a4b5d6ecbaecf72eb
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_neuro-secretory-Ionocyte_n_Brush\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FAT3 MUC16 PKD2L1 PSMD2 CDH22	1.06e-04	198	105	5	dd0465b45b02cb8edf0914d19afb52fcaaeb012c
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Hematopoietic-Megakaryocytic\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	MUC16 NDN DES CSPG4 PLXNB1	1.06e-04	198	105	5	ff6d9455ebfe965cc6f48197172c0ebd3bddde81
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Hematopoietic\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	MUC16 NDN DES CSPG4 PLXNB1	1.06e-04	198	105	5	5375a2895cf995f0db4a61861093f01794707901
ToppCell	Bronchial-10x5prime-Epithelial-Epi_airway_neuro-secretory\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PKD2L1 PLA2G4D CDH22 UNC80 CDH18	1.06e-04	198	105	5	2591e08e3fbee86ac40f11becd8147d6d39fded6
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Hematopoietic-Megakaryocytic-Megakaryocyte\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	MUC16 NDN DES CSPG4 PLXNB1	1.06e-04	198	105	5	35edf6d5bedc2181fbdd56f43e458bc39f4eca16
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DUSP4 DUSP5 AUTS2 TMEM238 IFI44L	1.09e-04	199	105	5	c3c73c9404a73133bfad1f9ced292f5e508ef767
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GABRB1 DCHS2 ACOT1 PLXNB1 GABBR1	1.11e-04	200	105	5	07d942803360e1a1e8e131d6e31c726dd0db1a0b
Drug	3-amino-2-butanone	CYP2D7 CYP2D6 PKD2L1 NT5C CSPG4	2.03e-06	46	103	5	CID004472117
Drug	hydroxynortriptyline	CYP2D7 CYP2D6 NT5C	4.95e-06	8	103	3	CID005352542
Drug	CP-101,606	CYP2D7 CYP2D6 GRIN2B	7.41e-06	9	103	3	CID000219101
Drug	E-10	CYP2D7 CYP2D6 CSPG4 NAGPA	1.65e-05	34	103	4	CID006452259
Drug	cupreidine	CYP2D7 CYP2D6	2.03e-05	2	103	2	CID000051196
Drug	3-methoxyphenethylamine	CYP2D7 CYP2D6	2.03e-05	2	103	2	CID000074866
Drug	Carbamazepine [298-46-4]; Down 200; 17uM; MCF7; HT_HG-U133A	DOHH DUSP5 KRI1 BAZ1B ARHGAP35 CPT1B CDC14B	3.21e-05	197	103	7	5518_DN
Drug	Thioproperazine dimesylate [2347-80-0]; Up 200; 6.2uM; MCF7; HT_HG-U133A	DUSP4 BAZ1B GRIN2B PIK3R2 MTM1 PGBD5 PLXNB1	3.21e-05	197	103	7	6265_UP
Drug	N6-methyladenosine [1867-73-8]; Up 200; 14.2uM; MCF7; HT_HG-U133A	CAPN9 DUSP4 BAZ1B ARHGAP35 DNAAF2 NCOR1 MTM1	3.21e-05	197	103	7	5332_UP
Drug	prostaglandin E2; Up 200; 10uM; MCF7; HT_HG-U133A	BAZ1B ECPAS NT5C MTM1 KAZN PLXNB1 CDH18	3.31e-05	198	103	7	6552_UP
Drug	clozapine	GABRB1 GABRD CYP2D7 CYP2D6 GRIN2B NT5C NT5C1A APOL4	3.52e-05	274	103	8	CID000002818
Drug	AC1L1B1W	GABRB1 GABRD GJD2 GRIN2B SLC4A5	4.00e-05	84	103	5	CID000001248
Drug	GW 6471	NOX4 ACOT1 CPT1B	4.82e-05	16	103	3	ctd:C449302
Drug	pregnanolone	GABRB1 GABRD CYP2D7 CYP2D6 GRIN2B	5.57e-05	90	103	5	CID000031402
Drug	1q66	MON1B NCOR1 PI4KA	5.84e-05	17	103	3	CID006323390
Drug	2,4,6-trimethylbenzaldoxime	CYP2D7 CYP2D6	6.06e-05	3	103	2	CID000283782
Drug	O-demethyl encainide	CYP2D7 CYP2D6	6.06e-05	3	103	2	CID000054736
Drug	chlorpromazine N-oxide	CYP2D7 CYP2D6	6.06e-05	3	103	2	CID000443037
Disease	developmental disorder of mental health (implicated_via_orthology)	GABRB1 GABRD GRIN2B NCOR1 PLXNB1	6.51e-07	49	99	5	DOID:0060037 (implicated_via_orthology)
Disease	solanidine measurement	CYP2D7 CYP2D6	6.66e-05	4	99	2	EFO_0800966
Disease	acute lymphoblastic leukemia (is_marker_for)	AICDA KDM3B CSPG4	2.03e-04	34	99	3	DOID:9952 (is_marker_for)
Disease	vascular dementia (is_marker_for)	GRIN2B NEFL	6.01e-04	11	99	2	DOID:8725 (is_marker_for)
Disease	depressive disorder (biomarker_via_orthology)	CYP2D7 FADD NEFL	7.19e-04	52	99	3	DOID:1596 (biomarker_via_orthology)
Disease	Schizophrenia	GABRB1 GABRD CYP2D6 GRIN2B OPA1 NEFL PI4KA APOL4 AUTS2 GABBR1	7.73e-04	883	99	10	C0036341
Disease	microglial activation measurement	FAT3 LZTS1 AUTS2	1.04e-03	59	99	3	EFO_0010940
Disease	biological sex	XRN2 FAT3 PKP4 AUTS2 GABBR1	1.09e-03	230	99	5	PATO_0000047
Disease	Myopia	GJD2 P3H2	1.14e-03	15	99	2	C0027092
Disease	Alpha ketoglutarate measurement	KCNV2 SLC13A3	1.30e-03	16	99	2	EFO_0010457
Disease	Malignant neoplasm of liver	ACOT1 CPT1B NCOR1 PRICKLE2	1.36e-03	142	99	4	C0345904
Disease	Liver neoplasms	ACOT1 CPT1B NCOR1 PRICKLE2	1.36e-03	142	99	4	C0023903
Disease	anxiety disorder (implicated_via_orthology)	KDM3B NCOR1	2.46e-03	22	99	2	DOID:2030 (implicated_via_orthology)
Disease	alcohol drinking	FAT3 AUTS2 LONRF2	2.59e-03	81	99	3	EFO_0004329
Disease	Epilepsy, Cryptogenic	GRIN2B P2RX4 AUTS2	2.68e-03	82	99	3	C0086237
Disease	response to selective serotonin reuptake inhibitor	GRIN2B AUTS2 KAZN	2.68e-03	82	99	3	EFO_0005658
Disease	Awakening Epilepsy	GRIN2B P2RX4 AUTS2	2.68e-03	82	99	3	C0751111
Disease	Aura	GRIN2B P2RX4 AUTS2	2.68e-03	82	99	3	C0236018
Disease	Sjogren's syndrome (is_marker_for)	MUC16 NEFL	2.93e-03	24	99	2	DOID:12894 (is_marker_for)
Disease	unipolar depression, response to selective serotonin reuptake inhibitor	CYP2D7 CYP2D6	2.93e-03	24	99	2	EFO_0003761, EFO_0005658

Protein segments in the cluster

Peptide	Gene	Start	Entry
ALLGIRDPRSEYDRT	PKP4	1051	Q99569
RYRADTLGELDLERA	ACOT1	51	Q86TX2
DYSELDPERFRREEL	FAM227A	296	F5H4B4
REDALRYTLDFLVPA	ARHGEF40	41	Q8TER5
DPELEGELDSRYARR	ANAPC2	196	Q9UJX6
ERRYSTVFLALDRDP	GJD2	106	Q9UKL4
LRVVSDREEPEAAYR	CSPG4	1966	Q6UVK1
LTPRELEIRRREDEY	CLPX	221	O76031
VNRRLRELYPDSEDV	NT5C1A	106	Q9BXI3
VRVAELPREEADALY	APOL4	66	Q9BPW4
RRDPQDDVYLDITDR	CDC14B	41	O60729
PERARLYEDRRSSAL	ASB2	401	Q96Q27
EEEDYEVAGLRLRPR	BAZ1B	1271	Q9UIG0
LPLYEVDDLRDAFRT	AICDA	181	Q9GZX7
PEYTRTLRVLEDRAL	ADCK5	161	Q3MIX3
DITDRLRFAILYSRP	CDC14C	21	A4D256
VARPLDREELDHYIL	CDH23	1481	Q9H251
LREALLDESRPLFER	DOHH	161	Q9BU89
PLGERRSDYDREALL	RCN2	31	Q14257
LLYRDRDRDLYPDSD	RBM15	571	Q96T37
AREQYRALRPDLADK	NT5C	46	Q8TCD5
LPRYSFRRLDTRDVE	P2RX4	271	Q99571
EAPYSREEERQRLSD	MON1B	436	Q7L1V2
ELLESGRELPRLRDY	RELCH	116	Q9P260
ALREQERLRLYTADP	DDI1	191	Q8WTU0
ERLRLYTADPLDREA	DDI1	196	Q8WTU0
SPLARRVDRVAIYEE	MUC16	14396	Q8WXI7
ERPLDRESRAEYNIT	PCDHB13	406	Q9Y5F0
LRLAIEDYRDAEAGR	KAZN	501	Q674X7
GELYRRTLDSDEERP	HIRIP3	521	Q9BW71
SSLAYEERPRRCRDE	LZTS1	291	Q9Y250
PLLYEEALRDEEERA	MAGEB4	301	O15481
HRRLYDDRNEPVLRL	MUC15	271	Q8N387
YEEPPEQLRELSRER	GPA33	281	Q99795
PENRRRYEAEITALE	DNAAF2	46	Q9NVR5
PDYSLVVRAAERARA	GJC2	331	Q5T442
LEDVNSRRDILPDYE	GABBR1	196	Q9UBS5
EHRNRLLADIRDYRP	IFI44L	176	Q53G44
RYLLLLAAGDPREEV	ECPAS	516	Q5VYK3
DNRLLREDVEYRPLT	PLXNB1	1736	O43157
ELRVLYAPRLDDSDC	ICAM5	401	Q9UMF0
TPRLYEADRSFRDRE	AUTS2	1106	Q8WXX7
DVAYRDPSLRDEILE	PI4KA	141	P42356
PVEYLLDRELRFLSD	KDM3B	136	Q7LBC6
PELDEGERFLRDYIL	KRI1	231	Q8N9T8
VDRLLKGYDIRLRPD	GABRB1	41	P18505
RARLRPIDADTIDIY	GABRD	416	O14764
EELIFRYLPDELSDR	LONRF2	506	Q1L5Z9
LDPLYRELERIQADE	P3H2	671	Q8IVL5
LNAARYRDEDPRKLL	NOX4	141	Q9NPH5
ERPLDRESRAEYNIT	PCDHB12	406	Q9Y5F1
DRERDPATYDLLVEA	DCHS2	731	Q6V1P9
LKDRPPLRAREDYDQ	PRICKLE2	711	Q7Z3G6
NYPRLRELDRNELFE	OPA1	581	O60313
ALYPFRRERPEDLEL	PIK3R2	11	O00459
RAPALLEAARARYES	PGBD5	11	Q8N414
AYDELLPALERALRE	LACTBL1	356	A8MY62
FSEERFRPSLEERLE	CTNNA1	296	P35221
EYDDPRFLRLLDLAQ	CYP2D6	196	P10635
TSEQYELRFRLLDPR	FNDC11	236	Q9BVV2
EGLIEREYLARTPED	CUL3	746	Q13618
SREARYDPSLLDVRL	CA8	56	P35219
REPTRVAELYEEELR	DES	146	P17661
LSLDDSYVERRRAPL	FAT3	3931	Q8TDW7
IDSIEDRYPRNLTER	FADD	126	Q13158
LYDEDILERDPLREQ	GON4L	1611	Q3T8J9
DPRRELEAEIYRLGS	AKNA	636	Q7Z591
EPRTLAAAKALRDRY	IFNL4	36	K9M1U5
LRNPSAAEELKYRRD	CDH18	676	Q13634
RYELDRDLNRLPQDL	IL25	91	Q9H293
RPVRYAIDRESDLDQ	CDH22	426	Q9UJ99
YRELLVHLDDPERAI	DNAAF5	791	Q86Y56
IDDRLPTFRDRLVFL	CAPN9	146	O14815
IVYDERSPRAESLRE	DUSP4	106	Q13115
LPADSRKEDEYRRNI	SLC13A3	216	Q8WWT9
SARYVLPDEAARARL	DUSP5	61	Q16690
QRYLESVRPLLDDEE	CPT1B	186	Q92523
SPERLASYRRELELR	PLA2G4D	401	Q86XP0
RSAPEDLRLLFYDEV	STK11IP	1026	Q8N1F8
KDTSLYRPALEELRR	PSMD2	66	Q13200
EYLLRLASTPDLRRF	KCNV2	316	Q8TDN2
RERIAAASSDLYLRP	NCOR1	1726	O75376
SRDDDLLLPYPRARA	NAGPA	31	Q9UK23
ALLRYLLDRDDPSDA	NCOA3	736	Q9Y6Q9
AAAALVEEETRRYRP	BCAS2	31	O75934
PYETDEDPRRRNILR	ARHGAP35	1206	Q9NRY4
DLLARDFERLGRLPY	ARAP1	856	Q96P48
EDLAREPLAEIRALY	CHST5	296	Q9GZS9
AEFLAYLLDPRTRRE	CHST13	226	Q8NET6
DAYRDLPRLLAVAES	CDK5RAP1	206	Q96SZ6
EYDDPRFLRLLDLAQ	CYP2D7	196	A0A087X1C5
RLEPRPLAILEDYAD	SHF	96	Q7M4L6
LDPELDRHRYERKIS	UNC80	1381	Q8N2C7
LLVVPYRASDDDLRR	MTM1	201	Q13496
CEILPEERRRAELDY	TBCE	371	Q15813
EAIQPYRDRLRSRLE	TRIM15	121	Q9C019
RRLRAALEEVYPDLT	XRN2	656	Q9H0D6
EDGLLRPELRERVSY	SLC4A5	196	Q9BY07
PYKREEEALEERRLS	PKD2L1	781	Q9P0L9
LERDYGLRPSALARL	TMEM238	101	C9JI98
IDLLYPTEDRNDRLR	SMYD2	241	Q9NRG4
KDSLRPEAARYLERL	THOP1	131	P52888
AYELTRREAEANRRP	USP13	516	Q92995
EFDEIELAYRRRPPR	GRIN2B	1101	Q13224
PSRYREALEEARALR	NDN	291	Q99608
EPSRFRALYEQEIRD	NEFL	131	P07196