Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	potassium ion leak channel activity	KCNK16 KCNK4 KCNK17	6.51e-05	16	100	3	GO:0022841
GeneOntologyMolecularFunction	narrow pore channel activity	KCNK16 KCNK4 KCNK17	1.11e-04	19	100	3	GO:0022842
GeneOntologyMolecularFunction	leak channel activity	KCNK16 KCNK4 KCNK17	1.11e-04	19	100	3	GO:0022840
GeneOntologyMolecularFunction	rRNA (cytosine-C5-)-methyltransferase activity	NSUN5 NSUN5P2	1.48e-04	4	100	2	GO:0009383
GeneOntologyMolecularFunction	outward rectifier potassium channel activity	KCNK16 KCNK4 KCNK17	3.27e-04	27	100	3	GO:0015271
GeneOntologyMolecularFunction	ribosome binding	PTTG1 DHX9 PTTG3P GCN1 PTTG2	3.44e-04	120	100	5	GO:0043022
GeneOntologyMolecularFunction	rRNA (cytosine) methyltransferase activity	NSUN5 NSUN5P2	3.68e-04	6	100	2	GO:0016434
GeneOntologyMolecularFunction	C-methyltransferase activity	NSUN5 NSUN5P2	6.82e-04	8	100	2	GO:0008169
GeneOntologyBiologicalProcess	mitotic sister chromatid cohesion	PTTG1 PTTG3P PDS5A NIPBL PTTG2	8.10e-07	36	100	5	GO:0007064
GeneOntologyBiologicalProcess	sister chromatid cohesion	PTTG1 PTTG3P PDS5A NIPBL PTTG2	1.84e-05	67	100	5	GO:0007062
GeneOntologyBiologicalProcess	homologous chromosome segregation	PTTG1 PTTG3P MLH1 ATM PTTG2	3.86e-05	78	100	5	GO:0045143
GeneOntologyBiologicalProcess	stabilization of membrane potential	KCNK16 KCNK4 KCNK17	7.16e-05	17	100	3	GO:0030322
GeneOntologyBiologicalProcess	meiosis I	PTTG1 TDRD9 PTTG3P MLH1 ATM PTTG2	8.13e-05	147	100	6	GO:0007127
GeneOntologyBiologicalProcess	meiosis I cell cycle process	PTTG1 TDRD9 PTTG3P MLH1 ATM PTTG2	1.09e-04	155	100	6	GO:0061982
MousePheno	small spleen	PTTG1 SLC40A1 RPS27L TGFB1 NSUN5 PTTG3P NSUN5P2 ATM POLQ VPS13B PTTG2	4.73e-06	416	68	11	MP:0000692
MousePheno	decreased pancreatic beta cell mass	ILDR2 PTTG1 PTTG3P PTTG2	1.66e-05	32	68	4	MP:0009114
MousePheno	abnormal cell cycle checkpoint function	PTTG1 PTTG3P ATM GCN1 PTTG2	1.67e-05	66	68	5	MP:0004045
MousePheno	decreased pancreatic beta cell proliferation	PTTG1 PTTG3P PTTG2	1.77e-05	11	68	3	MP:0011820
MousePheno	decreased spleen weight	PTTG1 RPS27L NSUN5 PTTG3P NSUN5P2 PTTG2	1.78e-05	113	68	6	MP:0004953
MousePheno	abnormal pancreatic beta cell mass	ILDR2 PTTG1 PTTG3P PTTG2	7.80e-05	47	68	4	MP:0009112
MousePheno	abnormal circulating alanine transaminase level	SETD6 FKBP9 SIRT3 TGFB1 NSUN5 ATG4B MLH1 NSUN5P2 PYGL TANC1	1.37e-04	498	68	10	MP:0001573
MousePheno	abnormal pancreatic beta cell proliferation	PTTG1 PTTG3P PTTG2	1.38e-04	21	68	3	MP:0011818
MousePheno	decreased circulating insulin level	ILDR2 PTTG1 ADCYAP1R1 TGFB1 PTTG3P DRAXIN PTTG2	1.52e-04	238	68	7	MP:0002727
MousePheno	hyperglycemia	ILDR2 PTTG1 SIRT3 PTTG3P PTTG2	1.56e-04	105	68	5	MP:0001559
MousePheno	increased circulating alanine transaminase level	SETD6 SIRT3 TGFB1 NSUN5 ATG4B MLH1 NSUN5P2 PYGL TANC1	1.62e-04	412	68	9	MP:0002941
Domain	Securin_separation-inh_met	PTTG1 PTTG2	2.67e-05	2	97	2	IPR018008
Domain	Cohesin_HEAT	INTS4 NIPBL	2.67e-05	2	97	2	PF12765
Domain	Securin	PTTG1 PTTG2	2.67e-05	2	97	2	PF04856
Domain	Cohesin_HEAT	INTS4 NIPBL	2.67e-05	2	97	2	IPR026003
Domain	Securin_separation_inhibitor	PTTG1 PTTG2	2.67e-05	2	97	2	IPR006940
Domain	HEAT_REPEAT	BTAF1 INTS4 PDS5A GCN1 NIPBL	3.16e-05	70	97	5	PS50077
Domain	2pore_dom_K_chnl	KCNK16 KCNK4 KCNK17	5.91e-05	15	97	3	IPR003280
Domain	ARM-type_fold	BTAF1 RRP12 INTS4 PDS5A ATM STKLD1 GCN1 NIPBL XPOT	6.76e-05	339	97	9	IPR016024
Domain	ARM-like	BTAF1 RRP12 INTS4 PDS5A STKLD1 GCN1 NIPBL XPOT	8.18e-05	270	97	8	IPR011989
Domain	-	BTAF1 RRP12 INTS4 PDS5A GCN1 NIPBL XPOT	1.58e-04	222	97	7	1.25.10.10
Domain	K_chnl_dom	KCNK16 KCNK4 KCNK17	1.69e-04	21	97	3	IPR013099
Domain	Ion_trans_2	KCNK16 KCNK4 KCNK17	1.69e-04	21	97	3	PF07885
Domain	HEAT	BTAF1 INTS4 GCN1 NIPBL	2.34e-04	58	97	4	IPR000357
Domain	MeTrfase_RsmB/NOP2	NSUN5 NSUN5P2	7.32e-04	8	97	2	IPR001678
Domain	Methyltr_RsmB-F	NSUN5 NSUN5P2	7.32e-04	8	97	2	PF01189
Domain	2pore_dom_K_chnl_TASK	KCNK16 KCNK17	9.39e-04	9	97	2	IPR003092
Pathway	REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS	KCNK16 KCNK4 KCNK17	2.29e-05	12	68	3	M1071
Pathway	REACTOME_PHASE_4_RESTING_MEMBRANE_POTENTIAL	KCNK16 KCNK4 KCNK17	9.84e-05	19	68	3	M27452
Pubmed	Mice lacking pituitary tumor transforming gene show testicular and splenic hypoplasia, thymic hyperplasia, thrombocytopenia, aberrant cell cycle progression, and premature centromere division.	PTTG1 PTTG3P PTTG2	2.31e-08	3	100	3	11682618
Pubmed	Pituitary Tumor Transforming Gene 1 Orchestrates Gene Regulatory Variation in Mouse Ventral Midbrain During Aging.	PTTG1 PTTG3P PTTG2	2.31e-08	3	100	3	33173537
Pubmed	PTTG1 Reprograms Asparagine Metabolism to Promote Hepatocellular Carcinoma Progression.	PTTG1 PTTG3P PTTG2	2.31e-08	3	100	3	37159932
Pubmed	Mad2 is required for inhibiting securin and cyclin B degradation following spindle depolymerisation in meiosis I mouse oocytes.	PTTG1 PTTG3P PTTG2	2.31e-08	3	100	3	16322543
Pubmed	PTTG1 alleviates acute alcoholic liver injury by inhibiting endoplasmic reticulum stress-induced hepatocyte pyroptosis.	PTTG1 PTTG3P PTTG2	2.31e-08	3	100	3	36737842
Pubmed	Pituitary senescence: the evolving role of Pttg.	PTTG1 PTTG3P PTTG2	2.31e-08	3	100	3	20153804
Pubmed	Pituitary tumor transforming gene (PTTG) transforming and transactivation activity.	PTTG1 PTTG3P PTTG2	2.31e-08	3	100	3	10713046
Pubmed	Sex-steroid milieu determines diabetes rescue in pttg-null mice.	PTTG1 PTTG3P PTTG2	2.31e-08	3	100	3	16731783
Pubmed	Mechanisms for growth factor-induced pituitary tumor transforming gene-1 expression in pituitary folliculostellate TtT/GF cells.	PTTG1 PTTG3P PTTG2	2.31e-08	3	100	3	16959877
Pubmed	Regulation of pituitary tumor transforming gene (PTTG) expression and phosphorylation in thyroid cells.	PTTG1 PTTG3P PTTG2	2.31e-08	3	100	3	23867215
Pubmed	Characterization of the pituitary tumor transforming gene 1 knockout mouse retina.	PTTG1 PTTG3P PTTG2	2.31e-08	3	100	3	21203837
Pubmed	PTTG is a secretory protein in human pituitary adenomas and in mouse pituitary tumor cell lines.	PTTG1 PTTG3P PTTG2	2.31e-08	3	100	3	17652795
Pubmed	Pttg1/securin is required for the branching morphogenesis of the mammary gland and suppresses mammary tumorigenesis.	PTTG1 PTTG3P PTTG2	2.31e-08	3	100	3	24395789
Pubmed	The lifespan quantitative trait locus gene Securin controls hematopoietic progenitor cell function.	PTTG1 PTTG3P PTTG2	2.31e-08	3	100	3	31073078
Pubmed	A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes.	PTTG1 PTTG3P PTTG2	2.31e-08	3	100	3	34262048
Pubmed	Pituitary tumor transforming gene as a novel regulatory factor of liver fibrosis.	PTTG1 PTTG3P PTTG2	2.31e-08	3	100	3	25936962
Pubmed	Discordant proliferation and differentiation in pituitary tumor-transforming gene-null bone marrow stem cells.	PTTG1 PTTG3P PTTG2	2.31e-08	3	100	3	17626243
Pubmed	Pituitary tumor transforming gene: an update.	PTTG1 PTTG3P PTTG2	2.31e-08	3	100	3	15281346
Pubmed	Securin and not CDK1/cyclin B1 regulates sister chromatid disjunction during meiosis II in mouse eggs.	PTTG1 PTTG3P PTTG2	2.31e-08	3	100	3	18639540
Pubmed	Pituitary tumor transforming gene-null male mice exhibit impaired pancreatic beta cell proliferation and diabetes.	PTTG1 PTTG3P PTTG2	2.31e-08	3	100	3	12626748
Pubmed	Maternal age-dependent APC/C-mediated decrease in securin causes premature sister chromatid separation in meiosis II.	PTTG1 PTTG3P PTTG2	2.31e-08	3	100	3	28516917
Pubmed	Characterization of the murine pituitary tumor transforming gene (PTTG) and its promoter.	PTTG1 PTTG3P PTTG2	2.31e-08	3	100	3	10650958
Pubmed	Murine pituitary tumor-transforming gene functions as a securin protein in insulin-secreting cells.	PTTG1 PTTG3P PTTG2	2.31e-08	3	100	3	17065388
Pubmed	Diminished pancreatic beta-cell mass in securin-null mice is caused by beta-cell apoptosis and senescence.	PTTG1 PTTG3P MLH1 PTTG2	4.51e-08	13	100	4	19213844
Pubmed	Anaphase B precedes anaphase A in the mouse egg.	PTTG1 PTTG3P PTTG2	9.21e-08	4	100	3	22342753
Pubmed	Securin and separase phosphorylation act redundantly to maintain sister chromatid cohesion in mammalian cells.	PTTG1 PTTG3P PTTG2	9.21e-08	4	100	3	16030258
Pubmed	Degradation of securin in mouse and pig oocytes is dependent on ubiquitin-proteasome pathway and is required for proteolysis of the cohesion subunit, Rec8, at the metaphase-to-anaphase transition.	PTTG1 PTTG3P PTTG2	9.21e-08	4	100	3	16720305
Pubmed	The pituitary tumor-transforming gene promotes angiogenesis in a mouse model of follicular thyroid cancer.	PTTG1 PTTG3P PTTG2	9.21e-08	4	100	3	17127711
Pubmed	Tumor suppressor activity of KLF6 mediated by downregulation of the PTTG1 oncogene.	PTTG1 PTTG3P PTTG2	9.21e-08	4	100	3	20116377
Pubmed	Pituitary tumor transforming gene 1 induces tumor necrosis factor-α production from keratinocytes: implication for involvement in the pathophysiology of psoriasis.	PTTG1 PTTG3P PTTG2	9.21e-08	4	100	3	23677169
Pubmed	Preimplantation mouse embryos depend on inhibitory phosphorylation of separase to prevent chromosome missegregation.	PTTG1 PTTG3P PTTG2	9.21e-08	4	100	3	19124608
Pubmed	Induction of Dlk1 by PTTG1 inhibits adipocyte differentiation and correlates with malignant transformation.	PTTG1 PTTG3P PTTG2	9.21e-08	4	100	3	19477929
Pubmed	The pituitary tumour-transforming gene 1/delta-like homologue 1 pathway plays a key role in liver fibrogenesis.	PTTG1 PTTG3P PTTG2	9.21e-08	4	100	3	35050550
Pubmed	Spatial learning and long-term memory impairments in RasGrf1 KO, Pttg1 KO, and double KO mice.	PTTG1 PTTG3P PTTG2	9.21e-08	4	100	3	30259712
Pubmed	Expression of PTTG and prc1 genes during telencephalic neurogenesis.	PTTG1 PTTG3P PTTG2	9.21e-08	4	100	3	10727870
Pubmed	Pituitary tumor-transforming gene 1 regulates the patterning of retinal mosaics.	PTTG1 PTTG3P PTTG2	9.21e-08	4	100	3	24927528
Pubmed	Glypican-1 regulates anaphase promoting complex/cyclosome substrates and cell cycle progression in endothelial cells.	PTTG1 PTTG3P PTTG2	9.21e-08	4	100	3	18417614
Pubmed	Pituitary hypoplasia in Pttg-/- mice is protective for Rb+/- pituitary tumorigenesis.	PTTG1 PTTG3P PTTG2	9.21e-08	4	100	3	15919720
Pubmed	Securin is not required for cellular viability, but is required for normal growth of mouse embryonic fibroblasts.	PTTG1 PTTG3P PTTG2	9.21e-08	4	100	3	11516952
Pubmed	Tumorigenic potential of pituitary tumor transforming gene (PTTG) in vivo investigated using a transgenic mouse model, and effects of cross breeding with p53 (+/-) transgenic mice.	PTTG1 PTTG3P PTTG2	9.21e-08	4	100	3	23164239
Pubmed	Abnormal megakaryocyte development and platelet function in Nbeal2(-/-) mice.	PTTG1 PTTG3P PTTG2	9.21e-08	4	100	3	23861251
Pubmed	The selective continued linkage of centromeres from mitosis to interphase in the absence of mammalian separase.	PTTG1 PTTG3P PTTG2	9.21e-08	4	100	3	16533944
Pubmed	Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression.	PTTG1 PTTG3P PTTG2	9.21e-08	4	100	3	16533945
Pubmed	Aberrant accumulation of PTTG1 induced by a mutated thyroid hormone beta receptor inhibits mitotic progression.	PTTG1 PTTG3P PTTG2	9.21e-08	4	100	3	17039256
Pubmed	Transcriptional profiling reveals functional links between RasGrf1 and Pttg1 in pancreatic beta cells.	PTTG1 PTTG3P PTTG2	9.21e-08	4	100	3	25421944
Pubmed	A single amino acid substitution (Cys249Trp) in Crb1 causes retinal degeneration and deregulates expression of pituitary tumor transforming gene Pttg1.	PTTG1 PTTG3P PTTG2	9.21e-08	4	100	3	17234588
Pubmed	Homologue disjunction in mouse oocytes requires proteolysis of securin and cyclin B1.	PTTG1 PTTG3P PTTG2	9.21e-08	4	100	3	14593421
Pubmed	Securin regulates entry into M-phase by modulating the stability of cyclin B.	PTTG1 PTTG3P PTTG2	9.21e-08	4	100	3	18364698
Pubmed	p21(Cip1) restrains pituitary tumor growth.	PTTG1 PTTG3P PTTG2	2.30e-07	5	100	3	18981426
Pubmed	MEIKIN expression and its C-terminal phosphorylation by PLK1 is closely related the metaphase-anaphase transition by affecting cyclin B1 and Securin stabilization in meiotic oocyte.	PTTG1 PTTG3P PTTG2	2.30e-07	5	100	3	39093409
Pubmed	PTTG-binding factor (PBF) is a novel regulator of the thyroid hormone transporter MCT8.	PTTG1 PTTG3P PTTG2	2.30e-07	5	100	3	22535767
Pubmed	Smurf1 targets Securin for ubiquitin-dependent degradation and regulates the metaphase-to-anaphase transition.	PTTG1 PTTG3P PTTG2	2.30e-07	5	100	3	28658604
Pubmed	The meiosis I-to-meiosis II transition in mouse oocytes requires separase activity.	PTTG1 PTTG3P PTTG2	2.30e-07	5	100	3	14561405
Pubmed	The Rae1-Nup98 complex prevents aneuploidy by inhibiting securin degradation.	PTTG1 PTTG3P PTTG2	2.30e-07	5	100	3	16355229
Pubmed	Altered expression of securin (Pttg1) and serpina3n in the auditory system of hearing-impaired Tff3-deficient mice.	PTTG1 PTTG3P PTTG2	2.30e-07	5	100	3	21076990
Pubmed	Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ phosphatase.	PTTG1 PTTG3P PTTG2	2.30e-07	5	100	3	21156286
Pubmed	Senescence mediates pituitary hypoplasia and restrains pituitary tumor growth.	PTTG1 PTTG3P PTTG2	2.30e-07	5	100	3	17975001
Pubmed	Involvement of histone deacetylase 1/2 in adrenocorticotropic hormone synthesis and proliferation of corticotroph tumor AtT-20 cells.	PTTG1 PTTG3P PTTG2	4.58e-07	6	100	3	33181265
Pubmed	mTOR promotes pituitary tumor development through activation of PTTG1.	PTTG1 PTTG3P PTTG2	4.58e-07	6	100	3	27524416
Pubmed	Function of COP9 signalosome in regulation of mouse oocytes meiosis by regulating MPF activity and securing degradation.	PTTG1 PTTG3P PTTG2	4.58e-07	6	100	3	21991377
Pubmed	Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein.	KCNK16 KCNK4 KCNK17	8.01e-07	7	100	3	18516069
Pubmed	Loss of Cdc20 causes a securin-dependent metaphase arrest in two-cell mouse embryos.	PTTG1 PTTG3P PTTG2	8.01e-07	7	100	3	17325031
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	PTTG1 YARS2 DHX9 THEM6 TTBK2 PTTG3P TSR1 RRP12 SNU13 PDS5A ATM GCN1 NIPBL VPS13B PTTG2	1.09e-06	1155	100	15	20360068
Pubmed	A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K(+) Channels.	KCNK16 KCNK4 KCNK17	1.28e-06	8	100	3	26919430
Pubmed	Identification of disease-relevant modulators of the SHH pathway in the developing brain.	PTTG1 PTTG3P PTTG2	1.91e-06	9	100	3	34463328
Pubmed	Nuclear pore protein NUP88 activates anaphase-promoting complex to promote aneuploidy.	PTTG1 PTTG3P PTTG2	2.73e-06	10	100	3	26731471
Pubmed	Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives.	ILDR2 PTTG1 GLTP KDM5D PTTG3P PYGL ATM PTTG2	3.02e-06	306	100	8	18973680
Pubmed	Separase phosphosite mutation leads to genome instability and primordial germ cell depletion during oogenesis.	PTTG1 PTTG3P PTTG2	3.74e-06	11	100	3	21494564
Pubmed	Specificity and Redundancy of Profilin 1 and 2 Function in Brain Development and Neuronal Structure.	PTTG1 PTTG3P PTTG2	6.46e-06	13	100	3	34571959
Pubmed	Gene signatures and prognostic analyses of the Tob/BTG pituitary tumor-transforming gene (PTTG) family in clinical breast cancer patients.	PTTG1 PTTG3P	8.18e-06	2	100	2	33173433
Pubmed	Mice with NOP2/sun RNA methyltransferase 5 deficiency die before reaching puberty due to fatal kidney damage.	NSUN5 NSUN5P2	8.18e-06	2	100	2	38712768
Pubmed	The mouse genomic instability mutation chaos1 is an allele of Polq that exhibits genetic interaction with Atm.	ATM POLQ	8.18e-06	2	100	2	15542845
Pubmed	ATM and TGFB1 genes polymorphisms in prediction of late complications of chemoradiotherapy in patients with locally advanced cervical cancer.	TGFB1 ATM	8.18e-06	2	100	2	24195511
Pubmed	Visualizing late states of human 40S ribosomal subunit maturation.	TSR1 RRP12	8.18e-06	2	100	2	29875412
Pubmed	RNA-methyltransferase Nsun5 controls the maternal-to-zygotic transition by regulating maternal mRNA stability.	NSUN5 NSUN5P2	8.18e-06	2	100	2	36495115
Pubmed	Sirtuin 3 Activation by Honokiol Decreases Unilateral Ureteral Obstruction-Induced Renal Inflammation and Fibrosis via Regulation of Mitochondrial Dynamics and the Renal NF-κBTGF-β1/Smad Signaling Pathway.	SIRT3 TGFB1	8.18e-06	2	100	2	31936371
Pubmed	TGF-β induced chemoresistance in liver cancer is modulated by xenobiotic nuclear receptor PXR.	TGFB1 NR1I2	8.18e-06	2	100	2	31739702
Pubmed	The lncRNA PTTG3P promotes the progression of CRPC via upregulating PTTG1.	PTTG1 PTTG3P	8.18e-06	2	100	2	33743960
Pubmed	Selenium compounds activate ATM-dependent DNA damage response via the mismatch repair protein hMLH1 in colorectal cancer cells.	MLH1 ATM	8.18e-06	2	100	2	20709753
Pubmed	SIRT3, a metabolic target linked to ataxia-telangiectasia mutated (ATM) gene deficiency in diffuse large B-cell lymphoma.	SIRT3 ATM	8.18e-06	2	100	2	33273545
Pubmed	Agenesis and Hypomyelination of Corpus Callosum in Mice Lacking Nsun5, an RNA Methyltransferase.	NSUN5 NSUN5P2	8.18e-06	2	100	2	31174389
Pubmed	NSUN5 is essential for proper cell proliferation and differentiation of mouse preimplantation embryos.	NSUN5 NSUN5P2	8.18e-06	2	100	2	38670153
Pubmed	Cognitive deficits in mice lacking Nsun5, a cytosine-5 RNA methyltransferase, with impairment of oligodendrocyte precursor cells.	NSUN5 NSUN5P2	8.18e-06	2	100	2	30485550
Pubmed	Identification of the human pituitary tumor transforming gene (hPTTG) family: molecular structure, expression, and chromosomal localization.	PTTG3P PTTG2	8.18e-06	2	100	2	10806349
Pubmed	The long non-coding RNA PTTG3P promotes cell growth and metastasis via up-regulating PTTG1 and activating PI3K/AKT signaling in hepatocellular carcinoma.	PTTG1 PTTG3P	8.18e-06	2	100	2	29803224
Pubmed	Loss of the ribosomal RNA methyltransferase NSUN5 impairs global protein synthesis and normal growth.	NSUN5 NSUN5P2	8.18e-06	2	100	2	31722427
Pubmed	Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma.	SLC40A1 GPNMB	8.18e-06	2	100	2	31675496
Pubmed	International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels.	KCNK16 KCNK4 KCNK17	8.20e-06	14	100	3	16382106
Pubmed	TIF1β association with HP1 is essential for post-gastrulation development, but not for Sertoli cell functions during spermatogenesis.	PTTG1 PTTG3P PTTG2	1.02e-05	15	100	3	21163256
Pubmed	Inhibitory phosphorylation of separase is essential for genome stability and viability of murine embryonic germ cells.	PTTG1 PTTG3P PTTG2	1.26e-05	16	100	3	18232736
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	LONP2 BTAF1 ZZEF1 EXOC8 PTK7 TSR1 AP5B1 MLH1 TANC1 ZC3H7B	1.86e-05	650	100	10	38777146
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	NEBL LONP2 ABCF2 RPS27L THEM6 NSUN5 TSR1 RRP12 MLH1 CDC42EP5 PDS5A ZFHX3 TANC1 ZC3H7B NIPBL	2.44e-05	1497	100	15	31527615
Pubmed	Knockdown of PTTG1 inhibits the growth and invasion of lung adenocarcinoma cells through regulation of TGFB1/SMAD3 signaling.	PTTG1 TGFB1	2.45e-05	3	100	2	25816405
Pubmed	NSUN5 Facilitates Viral RNA Recognition by RIG-I Receptor.	NSUN5 NSUN5P2	2.45e-05	3	100	2	33177158
Pubmed	Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels.	KCNK16 KCNK17	2.45e-05	3	100	2	11263999
Pubmed	Impaired genomic stability and increased oxidative stress exacerbate different features of Ataxia-telangiectasia.	MLH1 ATM	2.45e-05	3	100	2	16150740
Pubmed	Repair genes expression profile of MLH1, MSH2 and ATM in the normal oral mucosa of chronic smokers.	MLH1 ATM	2.45e-05	3	100	2	27693945
Pubmed	Transforming growth factor-β regulates the sphere-initiating stem cell-like feature in breast cancer through miRNA-181 and ATM.	TGFB1 ATM	2.45e-05	3	100	2	21102523
Pubmed	Murine candidate bleomycin induced pulmonary fibrosis susceptibility genes identified by gene expression and sequence analysis of linkage regions.	PTTG1 PTTG3P PTTG2	2.95e-05	21	100	3	15937080
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	PTTG1 EPPK1 KDM5D ARHGAP31 AP5B1 STON2 ATM ADGRL3	3.53e-05	430	100	8	35044719
GeneFamily	Potassium two pore domain channel subfamily K	KCNK16 KCNK4 KCNK17	1.54e-05	15	60	3	277
ToppCell	PND10-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NID2 UNC119 ATG4B AP5B1 PYGL GPNMB POLQ	1.16e-07	170	100	7	7534ac69ca3a378df78d61c284e89bc96a71a4a8
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SETD6 AP5B1 STON2 TANC1 POLQ FRMD5	2.29e-06	169	100	6	8a6d05b5d60b2b2e43a8ff7521feb79cd6dbd940
ToppCell	10x5'v1-week_14-16-Myeloid_neutrophil-granulo-neutrophil-myelocyte\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	EPPK1 TGFB1 NSUN5 STXBP2 AP5B1 PYGL	5.86e-06	199	100	6	a1635a52318be0423f8e4fc03d971c28cd22b57e
ToppCell	COVID-19_Mild-PLT_1\|COVID-19_Mild / Disease Group and Platelet Clusters	SLC40A1 TGFB1 STXBP2 STON2 PYGL ARHGAP45	5.86e-06	199	100	6	7f32958a73bc6020ea8a0e595ec749bbfe74c1b3
ToppCell	Neuronal-Inhibitory-iB-iB_3(PVALB-SST)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ADCY8 ADCYAP1R1 SIAH3 STON2 TANC1 FRMD5	6.03e-06	200	100	6	107854f4855fc99c9f7e737eb246f0d868e6c5fd
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; HL60; HG-U133A	ABCF2 EPS8L1 TSR1 RRP12 ATM ZC3H7B GCN1 XPOT	2.21e-06	195	99	8	1561_DN
Disease	heart conduction disease (implicated_via_orthology)	KCNK16 KCNK4 KCNK17	1.50e-04	32	95	3	DOID:10273 (implicated_via_orthology)
Disease	Cornelia de Lange syndrome (implicated_via_orthology)	PDS5A NIPBL	1.53e-04	6	95	2	DOID:11725 (implicated_via_orthology)
Disease	Inherited neuropathies	TTBK2 SACS ATM	2.93e-04	40	95	3	C0598589
Disease	alcohol use disorder (implicated_via_orthology)	EPS8L1 KDM5D ADCYAP1R1 CHRND STXBP2	4.29e-04	195	95	5	DOID:1574 (implicated_via_orthology)
Disease	Williams-Beuren syndrome (implicated_via_orthology)	NSUN5 NSUN5P2	1.05e-03	15	95	2	DOID:1928 (implicated_via_orthology)
Disease	aspartate aminotransferase to alanine aminotransferase ratio	EPPK1 CYP7A1 MLH1 STKLD1 ARHGAP45	1.07e-03	239	95	5	EFO_0010934
Disease	non-alcoholic steatohepatitis (is_marker_for)	CYP7A1 IRF5	1.52e-03	18	95	2	DOID:0080547 (is_marker_for)
Disease	Hereditary Non-Polyposis Colon Cancer Type 2	MLH1 ATM	1.69e-03	19	95	2	C1333991
Disease	Asthma	GSDMB ADCYAP1R1 TGFB1	2.22e-03	80	95	3	C0004096
Disease	serum IgM measurement	GSDMB UBXN7	2.27e-03	22	95	2	EFO_0004993
Disease	systemic scleroderma	GSDMB IRF5 ARHGAP31	2.64e-03	85	95	3	EFO_0000717
Disease	Hereditary Nonpolyposis Colorectal Neoplasms	MLH1 ATM	3.17e-03	26	95	2	C0009405
Disease	migraine disorder, pulse pressure measurement	TGFB1 STXBP2	3.17e-03	26	95	2	EFO_0005763, MONDO_0005277

Protein segments in the cluster

Peptide	Gene	Start	Entry
LLVLHLSLASAPMDP	ADCY8	196	P40145
MPLSSHLLPALVLFL	MAMDC4	1	Q6UXC1
FLETLPELLHMSRPA	CHRND	351	Q07001
RPFMLLLDEPTNHLD	ABCF2	246	Q9UG63
VFLMHLLLLQPGEPS	BTNL9	21	Q6UXG8
LAAAMLHLFDPTLEP	CFAP61	1006	Q8NHU2
LHMEDPDKPLLSSLF	GSDMB	306	Q8TAX9
LKDLPIMFDVLIHDP	GPNMB	256	Q14956
MLLAPIIHAFSRAPI	ADGRL3	11	Q9HAR2
EFHLPLEMPLSIFVE	CCER1	356	Q8TC90
LPMFELVELQPSHLA	ATG4B	346	Q9Y4P1
ELFAIDPHLLLSVMP	PDS5A	271	Q29RF7
TMLRQSAFLHLPLPE	INTS4	801	Q96HW7
GKHFLLDPLMPELLV	NSUN5	176	Q96P11
GFMDHPKLEIPLFLV	OR9I1	16	Q8NGQ6
EPHMPLLSIYSLALE	ARHGAP45	331	Q92619
LPPEMPILIDFHALK	LONP2	621	Q86WA8
LRAMASPPLDEHVFL	MATN4	181	O95460
HVPPELVRVLSAMLF	KCNK4	161	Q9NYG8
LVILIFPPMVFSHVE	KCNK16	181	Q96T55
LMKLPFTIPELVHAS	ERN2	101	Q76MJ5
MLTPELFDSQPDLLH	KDM5D	541	Q9BY66
LLEPRQYMLLLPEHV	FBXO46	466	Q6PJ61
LFLLLPPLLFSHMEG	KCNK17	191	Q96T54
MPELLVFPAQTDLHE	NSUN5P2	1	Q63ZY6
LELVVPLMEHPSETF	NIPBL	2051	Q6KC79
ARMTHALFPPDLVIL	PNPLA1	226	Q8N8W4
MAADAEPLEIILHLP	SNU13	56	P55769
HFIDAPSLALIMPIV	GCN1	1606	Q92616
DFPTVLLHMPFLEVI	LRRC10	181	Q5BKY1
LLPSLLHDPMALLAR	AP5B1	401	Q2VPB7
PDLLISPHMLPLTDL	IRF5	236	Q13568
LLRIQDIHPFATPLM	NR1I2	411	O75469
LLTAFILMGLPHAPA	OR10G8	6	Q8NGN5
HIIVANLYLLLPPTM	OR52N2	276	Q8NGI0
VLHSLPLEFPLAMAF	HECTD4	2686	Q9Y4D8
FPELHMVLLESLVEI	EXOC8	636	Q8IYI6
HVSLAALLLLPMAPA	ADCYAP1R1	6	P41586
LIILVTLADPMLHSP	OR10A2	31	Q9H208
LPLLMLRAAALHPDE	NID2	21	Q14112
IPPNSVLHFDVLLMD	FKBP9	126	O95302
LLHTMLDLEEFVPPV	FAM189B	231	P81408
LPTPVAEHSLELMLL	FRMD5	431	Q7Z6J6
VEGTLDLLELLIMHP	GSTA4	96	O15217
DLLELLIMHPFLKPD	GSTA4	101	O15217
PEIVVELLMTLHEPA	ATM	1341	Q13315
IHTAPMLFLVLLLPL	DRAXIN	6	Q8NBI3
LIPILPDMLRHIFQF	BTAF1	556	O14981
PEFILLAGEAPMTLH	FRMPD2	311	Q68DX3
LASPIHPDVVMLIAF	SLC1A2	66	P43004
SFLPHELPLLEGMET	POLQ	2011	O75417
SEHSLLPLMLEQFPF	CEP95	561	Q96GE4
DPLLSFHLDLGPSML	CDC42EP5	86	Q6NZY7
MALLAEHLLKPLPAD	GLTP	1	Q9NZD2
MELPFVTHLFLPLVF	ITGA10	1	O75578
IIALYPQLMHLDPEI	CYP7A1	386	P22680
MLLRVSPDHVTLLDP	EPS8L1	76	Q8TE68
PEGDVLLPLSLMHIA	SACS	3296	Q9NZJ4
LLPLSLMHIAVFPNA	SACS	3301	Q9NZJ4
PEMFRTPLHEIALSI	DHX9	791	Q08211
LVAPLPHSFLSFDLM	KBTBD6	466	Q86V97
IAHLPLSGVPLMILD	PTTG1	136	O95997
PGRVLPSDLDLLLHM	THEM6	51	Q8WUY1
LHLLMEIPCQFLELP	TDRD9	991	Q8NDG6
MPLARDLLHPSLEEE	RPS27L	1	Q71UM5
FTFLPLPEIDHIMQL	YARS2	321	Q9Y2Z4
PSLMLLIPHILLENF	SLC22A10	26	Q63ZE4
MLTEVPPSLSHILFL	GNRHR2	206	Q96P88
TEHLLPMGTALPLLE	EPPK1	306	P58107
IAHLPLSEVPLMILD	PTTG3P	136	Q9NZH4
IVLPFMEAHPDLFSL	SETD6	191	Q8TBK2
IVFLATDMHLPAPAD	SIAH3	141	Q8IW03
RFLLHVVDFPMADLL	SIRT3	301	Q9NTG7
PILNVALASLHPMTD	TANC1	756	Q9C0D5
LHFIMVILAPNPEAF	SLC40A1	506	Q9NP59
LMIILPPLSLGFHLE	OR6C68	151	A6NDL8
IAHLPLSGVPLMILD	PTTG2	136	Q9NZH5
LSEPAPLFDLAMLAL	MLH1	576	P40692
HMLTLLKDLLPCFPE	RRP12	306	Q5JTH9
VHPTTLPLLFLLAML	STON2	886	Q8WXE9
LVVPLHSRISLPEAM	TSR1	86	Q2NL82
SLPIDLEAEQHLMSP	ZBTB8A	376	Q96BR9
FPPLSEELISEMIRH	UNC119	196	Q13432
HPEEEPLLVMVYSLL	STKLD1	426	Q8NE28
LLADLLPSFAVEIMP	ILDR2	171	Q71H61
PFLLLMATPLERAQH	TGFB1	256	P01137
AHLLAITAPKDLPMF	SPAG1	826	Q07617
LIMDRAADPVSPLLH	STXBP2	231	Q15833
LMLKHLPPEFSIFLD	TTBK2	246	Q6IQ55
YLLEMKSLILPPEHI	ST7L	416	Q8TDW4
SLILFSPPFPIMDHL	ARHGAP31	1346	Q2M1Z3
HIPITLFMDLQAVLP	TMEM97	21	Q5BJF2
LSMIHIERFTPIPAL	SLC7A6	356	Q92536
MPLLHAIFEVLLRPA	XPOT	766	O43592
IVFSPLFIMRSHLPD	VPS13B	2841	Q7Z7G8
VPLIDLEHVLPLMFQ	ZZEF1	2106	O43149
TTLADLFRPPIDLMH	UBXN7	136	O94888
LVDPHFLPLPILAME	ZSWIM1	146	Q9BR11
THPALAIPELMRIFV	PYGL	341	P06737
TLHLAEIEDMPLFEP	PTK7	316	Q13308
LLPHFPMTTETLLQL	ZFHX3	1776	Q15911
TMPLFPHVLDLLAPL	ZC3H7B	226	Q9UGR2
MHDPVSDLPNLLFLD	NEBL	276	O76041