Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	sialic acid binding	SIGLEC12 SIGLEC9 SIGLEC14 SIGLEC6	5.97e-05	25	173	4	GO:0033691
GeneOntologyCellularComponent	extracellular matrix	COL4A5 RELN VWF FN1 EFEMP2 COL25A1 ERBIN ITGB4 ADAMTS12 ADAMTS10 LRIG1 ADAMTS9 ADAMTS15 NID1 PLXNA2	3.78e-04	656	173	15	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	COL4A5 RELN VWF FN1 EFEMP2 COL25A1 ERBIN ITGB4 ADAMTS12 ADAMTS10 LRIG1 ADAMTS9 ADAMTS15 NID1 PLXNA2	3.90e-04	658	173	15	GO:0030312
GeneOntologyCellularComponent	collagen-containing extracellular matrix	COL4A5 RELN VWF FN1 EFEMP2 COL25A1 ERBIN ITGB4 ADAMTS10 ADAMTS9 ADAMTS15 NID1 PLXNA2	4.86e-04	530	173	13	GO:0062023
GeneOntologyCellularComponent	basement membrane	COL4A5 FN1 EFEMP2 ERBIN ITGB4 NID1	5.39e-04	122	173	6	GO:0005604
Domain	Kinesin_assoc	KIF13B KIF13A KIF1C	1.43e-05	6	169	3	PF16183
Domain	Kinesin_assoc	KIF13B KIF13A KIF1C	1.43e-05	6	169	3	IPR032405
Domain	ADAM_spacer1	ADAMTS12 ADAMTS10 ADAMTS9 ADAMTS15	5.01e-05	23	169	4	IPR010294
Domain	ADAM_spacer1	ADAMTS12 ADAMTS10 ADAMTS9 ADAMTS15	5.01e-05	23	169	4	PF05986
Domain	Peptidase_M12B_ADAM-TS	ADAMTS12 ADAMTS10 ADAMTS9 ADAMTS15	5.97e-05	24	169	4	IPR013273
Domain	Pep_M12B_propep	ADAMTS12 ADAMTS10 ADAMTS9 ADAMTS15	4.16e-04	39	169	4	PF01562
Domain	Peptidase_M12B_N	ADAMTS12 ADAMTS10 ADAMTS9 ADAMTS15	4.16e-04	39	169	4	IPR002870
Domain	DISINTEGRIN_1	ADAMTS12 ADAMTS10 ADAMTS9 ADAMTS15	4.59e-04	40	169	4	PS00427
Domain	Reprolysin	ADAMTS12 ADAMTS10 ADAMTS9 ADAMTS15	4.59e-04	40	169	4	PF01421
Domain	ADAM_MEPRO	ADAMTS12 ADAMTS10 ADAMTS9 ADAMTS15	4.59e-04	40	169	4	PS50215
Domain	DISINTEGRIN_2	ADAMTS12 ADAMTS10 ADAMTS9 ADAMTS15	4.59e-04	40	169	4	PS50214
Domain	Peptidase_M12B	ADAMTS12 ADAMTS10 ADAMTS9 ADAMTS15	4.59e-04	40	169	4	IPR001590
Domain	Kinesin-like_KIF1-typ	KIF13B KIF13A	4.83e-04	4	169	2	IPR022140
Domain	KIF1B	KIF13B KIF13A	4.83e-04	4	169	2	PF12423
Domain	Disintegrin_dom	ADAMTS12 ADAMTS10 ADAMTS9 ADAMTS15	5.05e-04	41	169	4	IPR001762
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	RAD52 COL4A5 SHROOM3 TUT4 CACNA2D2 ASH1L HECTD4 HIPK2 RNF213 SYNPO ATP10A ERBIN NEK9 INKA2 BICD1 PCNX2 PHKB BMPR1B PWWP2B FUBP1 SHPRH AFF1 KDM2A PRKCI PISD BOD1L1 TMCC1 CREB3L2	2.41e-09	1489	177	28	28611215
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	KIF13B KDM5B SHROOM3 HIVEP1 COBLL1 INPP5F ERBIN NEK9 FSIP2 ZNF106 SYNE2 ZNF286B PRKCI TNKS1BP1 BOD1L1 KIF13A DNMBP AKAP1 RGL2 TMCC1 KIF1C	3.53e-09	861	177	21	36931259
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	COL4A5 SHROOM3 SZT2 HECTD4 POLRMT AMBRA1 IRF5 ICE1 ITGB4 RNF43 ARHGEF10L C2CD2L PCNX2 PWWP2B PLA2G4B NISCH TNKS1BP1 PRKDC DNMBP RGL2 DHX34 IQGAP3 BAHCC1	1.18e-08	1105	177	23	35748872
Pubmed	The murine inhibitory receptor mSiglec-E is expressed broadly on cells of the innate immune system whereas mSiglec-F is restricted to eosinophils.	SIGLEC12 SIGLEC9 SIGLEC14 SIGLEC6	2.24e-08	7	177	4	15048729
Pubmed	[Functions and molecular evolution of Siglecs, a family of sialic acid receptor proteins].	SIGLEC12 SIGLEC9 SIGLEC14 SIGLEC6	2.24e-08	7	177	4	18453149
Pubmed	Selective Response to Bacterial Infection by Regulating Siglec-E Expression.	SIGLEC12 SIGLEC9 SIGLEC14 SIGLEC6	2.08e-07	11	177	4	32889432
Pubmed	CD24-Siglec axis is an innate immune checkpoint against metaflammation and metabolic disorder.	SIGLEC12 SIGLEC9 SIGLEC14 SIGLEC6	4.47e-07	13	177	4	35921817
Pubmed	Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	COBLL1 ICE1 INPP5F NISCH SYNE2 KDM2A DNMBP	9.65e-07	102	177	7	10231032
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	TUT4 UBE2Q1 NMNAT1 HIPK2 INPP5F DMXL1 GGT5 ADAMTS12 ADAMTS10 BMPR1B PLA2G4B FUBP1 ADAMTS15 KDM2A PRKCI ATP4A	1.16e-06	730	177	16	34857952
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SHROOM3 SZT2 HECTD4 TOPBP1 AMBRA1 SYNPO ICE1 NCSTN INPP5F ARHGEF10L TNKS1BP1 DNMBP DHX34	3.58e-06	529	177	13	14621295
Pubmed	Hypoplastic basement membrane of the lens anlage in the inheritable lens aplastic mouse (lap mouse).	COL4A5 FN1 NID1	4.47e-06	7	177	3	10716744
Pubmed	alpha3beta1 Integrin is required for normal development of the epidermal basement membrane.	FN1 ITGB4 NID1	4.47e-06	7	177	3	9151677
Pubmed	Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms.	SIGLEC12 SIGLEC9 SIGLEC14 SIGLEC6	6.36e-06	24	177	4	15331780
Pubmed	Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1.	SIGLEC12 SIGLEC9 SIGLEC6	7.12e-06	8	177	3	25187624
Pubmed	A human MAP kinase interactome.	HIVEP1 VWF COBLL1 HIPK2 SYNPO ERBIN ITGB4 ZNF106 KDM2A CCDC97 PRKDC RGL2	8.16e-06	486	177	12	20936779
Pubmed	Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs.	SIGLEC12 SIGLEC9 SIGLEC6	1.51e-05	10	177	3	25320078
Pubmed	ADAMTS: a novel family of extracellular matrix proteases.	ADAMTS12 ADAMTS10 ADAMTS9	1.51e-05	10	177	3	11167130
Pubmed	Binding of mouse and human fibulin-2 to extracellular matrix ligands.	COL4A5 FN1 NID1	2.08e-05	11	177	3	7500359
Pubmed	Bile acids: natural ligands for an orphan nuclear receptor.	NCOA1 NR1H4	2.58e-05	2	177	2	10334993
Pubmed	Identification of a nuclear receptor for bile acids.	NCOA1 NR1H4	2.58e-05	2	177	2	10334992
Pubmed	Selection on cis-regulatory variation at B4galnt2 and its influence on von Willebrand factor in house mice.	VWF B4GALNT2	2.58e-05	2	177	2	19088380
Pubmed	Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation.	NCOA1 NR1H4	2.58e-05	2	177	2	18391212
Pubmed	Correlation of farnesoid X receptor coactivator recruitment and cholesterol 7alpha-hydroxylase gene repression by bile acids.	NCOA1 NR1H4	2.58e-05	2	177	2	11136553
Pubmed	Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.	STRC STRCP1	2.58e-05	2	177	2	34910522
Pubmed	αv-Class integrin binding to fibronectin is solely mediated by RGD and unaffected by an RGE mutation.	FN1 NID1	2.58e-05	2	177	2	33141174
Pubmed	The farnesoid X receptor controls gene expression in a ligand- and promoter-selective fashion.	NCOA1 NR1H4	2.58e-05	2	177	2	14684751
Pubmed	Laminar distribution of synaptopodin in normal and reeler mouse brain depends on the position of spine-bearing neurons.	RELN SYNPO	2.58e-05	2	177	2	12357430
Pubmed	Inhibition of the histone demethylase Kdm5b promotes neurogenesis and derepresses Reln (reelin) in neural stem cells from the adult subventricular zone of mice.	KDM5B RELN	2.58e-05	2	177	2	26739753
Pubmed	Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.	STRC STRCP1	2.58e-05	2	177	2	11687802
Pubmed	In vitro farnesoid X receptor ligand sensor assay using surface plasmon resonance and based on ligand-induced coactivator association.	NCOA1 NR1H4	2.58e-05	2	177	2	14698205
Pubmed	Plasma fibronectin supports hemostasis and regulates thrombosis.	VWF FN1	2.58e-05	2	177	2	25180602
Pubmed	Matrilin-2 interacts with itself and with other extracellular matrix proteins.	COL4A5 FN1 NID1	2.76e-05	12	177	3	12180907
Pubmed	Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics.	ADAMTS12 ADAMTS10 ADAMTS9	2.76e-05	12	177	3	25770910
Pubmed	Cytoplasmic plaque formation in hemidesmosome development is dependent on SoxF transcription factor function.	VWF ITGB4 NID1	3.57e-05	13	177	3	22962592
Pubmed	Basal lamina molecules are concentrated in myogenic regions of the mouse limb bud.	COL4A5 FN1 NID1	3.57e-05	13	177	3	9833687
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	CUBN ADAMTS12 ADAMTS10 ADAMTS9 ADAMTS15	4.17e-05	75	177	5	20637190
Pubmed	A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis.	CACNA1B ETV6 STRC STRCP1	4.18e-05	38	177	4	38346162
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CSMD3 ERBIN RNF157 C2CD2L NISCH BOD1L1 ASXL2 TRAK2 ST18 PLXNA2	4.90e-05	407	177	10	12693553
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KIF13B COBLL1 RNF213 ATP10A NEK9 ADAMTS9 ZNF286B IRF2BPL KDM2A TMCC1 KIF1C	4.91e-05	493	177	11	15368895
Pubmed	Functional proteomics mapping of a human signaling pathway.	HIVEP1 VWF FN1 ASH1L ERBIN ZNF106 POLI AFF1 NID1 KDM2A ASXL2 KIF13A	5.52e-05	591	177	12	15231748
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	KDM5B HIVEP1 POLRMT ICE1 INPP5F NEK9 MSTO1 TMF1 TNKS1BP1 AKAP1	6.11e-05	418	177	10	34709266
Pubmed	Suppression of C/EBPalpha expression in periportal hepatoblasts may stimulate biliary cell differentiation through increased Hnf6 and Hnf1b expression.	ITGB4 NID1 PRKDC	6.91e-05	16	177	3	17021047
Pubmed	Perinatal lethality and endothelial cell abnormalities in several vessel compartments of fibulin-1-deficient mice.	FN1 SYNPO NID1	6.91e-05	16	177	3	11564885
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	HIVEP1 NMNAT1 DCUN1D5 TOPBP1 SYNPO CMAS FSIP2 TADA2B SHPRH TMPO KDM2A BOD1L1	7.23e-05	608	177	12	36089195
Pubmed	High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.	LINC01600 UBE2Q1 SZT2 HIPK2 SYNPO COL25A1 ARHGEF10L ADAMTS10 TRAFD1 ADAMTS15 B4GALNT2 TNKS1BP1 AKAP1 TMCC1 GABBR1 KIF1C	7.28e-05	1021	177	16	26760575
Pubmed	Haptoglobin phenotype and the risk of restenosis after coronary artery stent implantation.	ACE HP	7.70e-05	3	177	2	11909563
Pubmed	Identification of two new members of the CSMD gene family.	CSMD2 CSMD3	7.70e-05	3	177	2	12906867
Pubmed	Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.	STRC STRCP1	7.70e-05	3	177	2	30801007
Pubmed	Cloning and characterization of a novel mouse Siglec, mSiglec-F: differential evolution of the mouse and human (CD33) Siglec-3-related gene clusters.	SIGLEC14 SIGLEC6	7.70e-05	3	177	2	11579105
Pubmed	Mast Cell-Specific Expression of Human Siglec-8 in Conditional Knock-in Mice.	SIGLEC14 SIGLEC6	7.70e-05	3	177	2	30577572
Pubmed	Multiple tumor-suppressor genes on chromosome 3p contribute to head and neck squamous cell carcinoma tumorigenesis.	XIRP1 ALS2CL	7.70e-05	3	177	2	20657180
Pubmed	A novel Siglec-F+ neutrophil subset in the mouse nasal mucosa exhibits an activated phenotype and is increased in an allergic rhinitis model.	SIGLEC14 SIGLEC6	7.70e-05	3	177	2	32247614
Pubmed	Platelets, inflammatory cells, von Willebrand factor, syndecan-1, fibrin, fibronectin, and bacteria co-localize in the liver thrombi of Bacillus anthracis-infected mice.	VWF FN1	7.70e-05	3	177	2	22001909
Pubmed	Retinoic acid represses CYP7A1 expression in human hepatocytes and HepG2 cells by FXR/RXR-dependent and independent mechanisms.	NCOA1 NR1H4	7.70e-05	3	177	2	20338915
Pubmed	Frequency and clinical impact of ETV6/RUNX1, AF4-MLL, and BCR/ABL fusion genes on features of acute lymphoblastic leukemia at presentation.	ETV6 AFF1	7.70e-05	3	177	2	26856288
Pubmed	The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching.	CD40 PRKDC	7.70e-05	3	177	2	8885865
Pubmed	Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis.	SIGLEC14 SIGLEC6	7.70e-05	3	177	2	25497369
Pubmed	Negative regulation of beta4 integrin transcription by homeodomain-interacting protein kinase 2 and p53 impairs tumor progression.	HIPK2 ITGB4	7.70e-05	3	177	2	19567674
Pubmed	LncRNA ADAMTS9-AS2 regulates periodontal ligament cell migration under mechanical compression via ADAMTS9/fibronectin.	FN1 ADAMTS9	7.70e-05	3	177	2	37957805
Pubmed	Siglec-F-dependent negative regulation of allergen-induced eosinophilia depends critically on the experimental model.	SIGLEC14 SIGLEC6	7.70e-05	3	177	2	24698729
Pubmed	Reelin signaling modulates GABAB receptor function in the neocortex.	RELN GABBR1	7.70e-05	3	177	2	32083308
Pubmed	Siglec-F is induced by granulocyte-macrophage colony-stimulating factor and enhances interleukin-4-induced expression of arginase-1 in mouse macrophages.	SIGLEC14 SIGLEC6	7.70e-05	3	177	2	31520477
Pubmed	Antiallergic effect of anti-Siglec-F through reduction of eosinophilic inflammation in murine allergic rhinitis.	SIGLEC14 SIGLEC6	7.70e-05	3	177	2	23710953
Pubmed	Anti-Siglec-F antibody reduces allergen-induced eosinophilic inflammation and airway remodeling.	SIGLEC14 SIGLEC6	7.70e-05	3	177	2	19783675
Pubmed	γ-Aminobutyric acid type B (GABAB) receptor expression is needed for inhibition of N-type (Cav2.2) calcium channels by analgesic α-conotoxins.	CACNA1B GABBR1	7.70e-05	3	177	2	22613715
Pubmed	Ligand binding and heterodimerization with retinoid X receptor α (RXRα) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding.	NCOA1 NR1H4	7.70e-05	3	177	2	30275017
Pubmed	Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development.	VWF FN1	7.70e-05	3	177	2	10625534
Pubmed	Fibronectin 1 derived from tumor-associated macrophages and fibroblasts promotes metastasis through the JUN pathway in hepatocellular carcinoma.	FN1 KIF13A	7.70e-05	3	177	2	36461607
Pubmed	CD40/CD40L contributes to hypercholesterolemia-induced microvascular inflammation.	CD40 PRKDC	7.70e-05	3	177	2	19112095
Pubmed	Variants in DNA double-strand break repair and DNA damage-response genes and susceptibility to lung and head and neck cancers.	RAD52 PRKDC	7.70e-05	3	177	2	18449888
Pubmed	The depletion of Circ-PRKDC enhances autophagy and apoptosis in T-cell acute lymphoblastic leukemia via microRNA-653-5p/Reelin mediation of the PI3K/AKT/mTOR signaling pathway.	RELN PRKDC	7.70e-05	3	177	2	33615686
Pubmed	Mice lacking the extracellular matrix protein MAGP1 display delayed thrombotic occlusion following vessel injury.	VWF FN1	7.70e-05	3	177	2	18281502
Pubmed	MiR-16 mediates trastuzumab and lapatinib response in ErbB-2-positive breast and gastric cancer via its novel targets CCNJ and FUBP1.	CCNJ FUBP1	7.70e-05	3	177	2	27157613
Pubmed	Frontline Science: Superior mouse eosinophil depletion in vivo targeting transgenic Siglec-8 instead of endogenous Siglec-F: Mechanisms and pitfalls.	SIGLEC14 SIGLEC6	7.70e-05	3	177	2	32134149
Pubmed	The self-association and fibronectin-binding sites of fibulin-1 map to calcium-binding epidermal growth factor-like domains.	FN1 NID1	7.70e-05	3	177	2	9278415
Pubmed	IRF5 guides monocytes toward an inflammatory CD11c+ macrophage phenotype and promotes intestinal inflammation.	IRF5 ITGAX	7.70e-05	3	177	2	32444476
Pubmed	Endothelial CD40 Mediates Microvascular von Willebrand Factor-Dependent Platelet Adhesion Inducing Inflammatory Venothrombosis in ADAMTS13 Knockout Mice.	VWF CD40	7.70e-05	3	177	2	32135568
Pubmed	Siglec-F is a novel intestinal M cell marker.	SIGLEC14 SIGLEC6	7.70e-05	3	177	2	27524237
Pubmed	Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus.	COL4A5 FN1 NID1	8.36e-05	17	177	3	18082680
Pubmed	Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization.	SIGLEC14 SIGLEC6 PRKDC	8.36e-05	17	177	3	35709757
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	KDM5B RELN VWF FN1 EFEMP2 ASH1L HECTD4 SYNPO CMAS MSTO1 BICD1 ADAMTS9 NISCH ZNF624 EXOC1 PRKDC ST18 MAPK8IP2	1.06e-04	1285	177	18	35914814
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	FAM47A FN1 RNF213 ZC2HC1C ICE1 CSMD2 ADAMTS9 ALDH16A1 MYO3B ADAMTS15 TMPO BOD1L1 PRKDC	1.10e-04	736	177	13	29676528
Pubmed	Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation.	UBE2Q1 DCUN1D5 ACE	1.39e-04	20	177	3	25340798
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	KIF13B COL4A5 FN1 UBE2Q1 ASH1L HIPK2 PHTF2 NCSTN CUBN ERBIN ITGB4 PHKB AFF1 BOD1L1 ASXL2 KIF13A	1.45e-04	1084	177	16	11544199
Pubmed	Serum amyloid p component does not circulate in complex with C4-binding protein, fibronectin or any other major protein ligand.	FN1 ITGAX	1.53e-04	4	177	2	12100475
Pubmed	Distinct endocytic mechanisms of CD22 (Siglec-2) and Siglec-F reflect roles in cell signaling and innate immunity.	SIGLEC14 SIGLEC6	1.53e-04	4	177	2	17562860
Pubmed	Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils.	SIGLEC14 SIGLEC6	1.53e-04	4	177	2	17272508
Pubmed	Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.	STRC STRCP1	1.53e-04	4	177	2	18849963
Pubmed	Human-specific elimination of epithelial Siglec-XII suppresses the risk of inflammation-driven colorectal cancers.	SIGLEC12 SIGLEC9	1.53e-04	4	177	2	38990656
Pubmed	Leishmania donovani Utilize Sialic Acids for Binding and Phagocytosis in the Macrophages through Selective Utilization of Siglecs and Impair the Innate Immune Arm.	SIGLEC12 SIGLEC9	1.53e-04	4	177	2	27494323
Pubmed	Siglec-9 acts as an immune-checkpoint molecule on macrophages in glioblastoma, restricting T-cell priming and immunotherapy response.	SIGLEC12 SIGLEC9	1.53e-04	4	177	2	37460871
Pubmed	Group B Streptococcus engages an inhibitory Siglec through sialic acid mimicry to blunt innate immune and inflammatory responses in vivo.	SIGLEC12 SIGLEC9	1.53e-04	4	177	2	24391502
Pubmed	RNF144A, an E3 ubiquitin ligase for DNA-PKcs, promotes apoptosis during DNA damage.	RNF144B PRKDC	1.53e-04	4	177	2	24979766
Pubmed	The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis.	SIGLEC12 SIGLEC9	1.53e-04	4	177	2	38454157
Pubmed	Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells.	SIGLEC12 SIGLEC9	1.53e-04	4	177	2	30130255
Pubmed	Siglec receptors impact mammalian lifespan by modulating oxidative stress.	SIGLEC12 SIGLEC9	1.53e-04	4	177	2	25846707
Pubmed	Immunosuppressive Siglec-E ligands on mouse aorta are up-regulated by LPS via NF-κB pathway.	SIGLEC12 SIGLEC9	1.53e-04	4	177	2	31918287
Pubmed	Sialylated ligands on pathogenic Trypanosoma cruzi interact with Siglec-E (sialic acid-binding Ig-like lectin-E).	SIGLEC12 SIGLEC9	1.53e-04	4	177	2	19552697
Pubmed	Targeting the Siglec-sialic acid axis promotes antitumor immune responses in preclinical models of glioblastoma.	SIGLEC12 SIGLEC9	1.53e-04	4	177	2	37467314
Pubmed	Siglec-8 on human eosinophils and mast cells, and Siglec-F on murine eosinophils, are functionally related inhibitory receptors.	SIGLEC14 SIGLEC6	1.53e-04	4	177	2	19178537
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS12 ADAMTS10 ADAMTS9 ADAMTS15	4.86e-06	19	111	4	50
GeneFamily	CD molecules\|C2-set domain containing\|Sialic acid binding Ig like lectins	SIGLEC12 SIGLEC9 SIGLEC14 SIGLEC6	2.46e-05	28	111	4	745
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	CSMD2 CSMD3 HP GABBR1	4.14e-04	57	111	4	1179
GeneFamily	CD molecules\|Activating leukocyte immunoglobulin like receptors	LILRA1 LILRA4	5.51e-04	6	111	2	1181
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	LILRA1 SIGLEC9 ACE ITGAX ITGB4 BMPR1B SIGLEC6 CD40 LILRA4	7.23e-04	394	111	9	471
GeneFamily	Ring finger proteins	RNF144B TRIM49D1 RNF213 RNF43 RNF157 SHPRH MARCHF11	1.54e-03	275	111	7	58
GeneFamily	PHD finger proteins	KDM5B ASH1L SHPRH KDM2A	2.29e-03	90	111	4	88
GeneFamily	Kinesins\|Pleckstrin homology domain containing	KIF13B KIF13A KIF1C	2.82e-03	46	111	3	622
Coexpression	GSE17721_LPS_VS_POLYIC_2H_BMDC_DN	KDM5B ASH1L TOPBP1 NEK9 CYFIP2 PHKB GSTZ1 FUBP1 ADAMTS15 PISD RGL2 C8orf33 KIF1C	8.09e-10	200	172	13	M3802
Coexpression	REN_ALVEOLAR_RHABDOMYOSARCOMA_UP	VWF CACNA2D2 CYFIP2 ZNF106 SYNE2 NCOA1 ASXL2	4.16e-06	99	172	7	M768
Coexpression	GSE2405_S_AUREUS_VS_A_PHAGOCYTOPHILUM_NEUTROPHIL_DN	NMNAT1 SZT2 POLRMT MAMDC4 RNF157 C2CD2L DNMBP PIGO GABBR1	7.37e-06	200	172	9	M6208
Coexpression	LAKE_ADULT_KIDNEY_C2_PODOCYTES	NPAS3 ALS2CL ATP10A ERBIN BICD1 PLA2R1 ADAMTS9 NCOA1 KIF13A	1.18e-05	212	172	9	M39221
Coexpression	NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP	KDM5B LILRA1 ATP10A SIGLEC6 CD40 TMPO DHX34 TMCC1 GABBR1	1.52e-05	219	172	9	M41199
Coexpression	KIM_MYC_AMPLIFICATION_TARGETS_DN	KIF13B SPAG1 SHROOM3 HECTD4 ETV6 PLXNA2	4.68e-05	98	172	6	M6319
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	KDM5B TUT4 HIVEP1 TOPBP1 INPP5F BICD1 LRIG1 FUBP1 SYNE2 NCOA1 AFF1 PRKCI BCAR3 DNMBP TMCC1 MYBL1 CREB3L2	5.17e-05	856	172	17	M4500
Coexpression	GSE30083_SP1_VS_SP4_THYMOCYTE_DN	ADGRG5 RNF213 ALS2CL TRAFD1 IGFBP4 ZBTB25 SYNE2 PRKDC	5.53e-05	200	172	8	M5030
Coexpression	GSE22140_GERMFREE_VS_SPF_ARTHRITIC_MOUSE_CD4_TCELL_UP	FN1 EFEMP2 DMXL1 NISCH TMF1 TACC1 BCAR3 DNMBP	5.53e-05	200	172	8	M7649
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN	TUT4 HIVEP1 TOPBP1 INPP5F FUBP1 NCOA1 AFF1 PRKCI BCAR3 DNMBP MYBL1 CREB3L2	6.30e-05	466	172	12	M13522
Coexpression	GSE37532_VISCERAL_ADIPOSE_TISSUE_VS_LN_DERIVED_PPARG_KO_TCONV_CD4_TCELL_DN	SZT2 AMBRA1 FSIP2 NID1 GABBR1 CREB3L2	6.52e-05	104	172	6	M8938
ToppCell	COVID-19-Heart-EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	RNF144B VWF COBLL1 HIPK2 ADAMTS12 ADAMTS9 SYNE2 TACC1 PLXNA2	6.65e-08	190	175	9	a21653bfb7bafbc273f94fa7c13bfb48cf8fd562
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_B-ABC_aged-B_memory\|lymph-node_spleen / Manually curated celltypes from each tissue	ADGRG5 IRF5 SYNPO INPP5F ITGAX SIGLEC6 CD40 BCAR3 LILRA4	7.95e-08	194	175	9	b57ae94a092b58623a244a258b4659a3864542c7
ToppCell	Caecum-(4)_Monocyte\|Caecum / shred on region, Cell_type, and subtype	SIGLEC12 RNF144B LILRA1 SIGLEC9 SIGLEC14 ITGAX CXCL3 HP BAHCC1	1.03e-07	200	175	9	6bfd6ab395e09087aeedc9a7c9ada1b4b8a26194
ToppCell	Caecum-Monocyte-Monocyte\|Caecum / Region, Cell class and subclass	SIGLEC12 RNF144B LILRA1 SIGLEC9 SIGLEC14 ITGAX CXCL3 HP BAHCC1	1.03e-07	200	175	9	d33619b6c721eae3ebe50fba6b9d31fa99f2248f
ToppCell	Caecum-(4)_Monocyte-(40)_Monocyte\|Caecum / shred on region, Cell_type, and subtype	SIGLEC12 RNF144B LILRA1 SIGLEC9 SIGLEC14 ITGAX CXCL3 HP BAHCC1	1.03e-07	200	175	9	b078058efc51f0ff4d92123b712933b32824c655
ToppCell	Caecum-Monocyte\|Caecum / Region, Cell class and subclass	SIGLEC12 RNF144B LILRA1 SIGLEC9 SIGLEC14 ITGAX CXCL3 HP BAHCC1	1.03e-07	200	175	9	9e8d38d024a315512521b349e8ac7caa56219daf
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWF COBLL1 ACE ATP10A MSMP GGT5 IGFBP4 NID1 PLXNA2	1.03e-07	200	175	9	061ba851f941c616ddb462512e826c412881c3ce
ToppCell	droplet-Liver-Npc-18m-Lymphocytic-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRG5 VWF SZT2 PHTF2 ADAMTS10 PLA2G4B PRKDC BAHCC1	5.42e-07	178	175	8	09d2687e0d79f12e90af35fc1c0453d249cf2d19
ToppCell	droplet-Lung-1m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	VWF COBLL1 SYNPO ITGB4 SYT15 LRIG1 ADAMTS9 CREB3L2	6.15e-07	181	175	8	136b0c60680068838d184d32aa99d7bea8718dbc
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COBLL1 NPAS3 PHTF2 BICD1 BMPR1B B4GALNT2 AFF1 BCAR3	7.26e-07	185	175	8	d602a9b35e86e6f2a14a58e40fc4fb97f5fa3b08
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B RELN CACNA2D2 NPAS3 COL25A1 ADAMTS9 MARCHF11 SHISA6	7.87e-07	187	175	8	85f1678338a47d91e296f0620d4887f057eb7e70
ToppCell	COVID-19-Heart-EC_2\|Heart / Disease (COVID-19 only), tissue and cell type	RNF144B VWF COBLL1 ITGB4 ADAMTS9 SYNE2 TACC1 PLXNA2	7.87e-07	187	175	8	40ffc06a3e3251d9b12da390210d3e045af7537a
ToppCell	renal_medulla_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A5 COBLL1 AMBRA1 CYFIP2 BMPR1B MYO3B ADAMTS15 TACC1	8.53e-07	189	175	8	830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWF COBLL1 ACE ATP10A MSMP GGT5 IGFBP4 PLXNA2	9.98e-07	193	175	8	3f8280ef849d95b2fcea5e6824b95a07febc96d0
ToppCell	RV-10._Endothelium_II\|World / Chamber and Cluster_Paper	VWF HIPK2 ATP10A BMPR1B ADAMTS9 SYNE2 TACC1 PLXNA2	9.98e-07	193	175	8	2531266bc57339d4e2b22a88817008e32b8c1598
ToppCell	RV-10._Endothelium_II\|RV / Chamber and Cluster_Paper	VWF FN1 HIPK2 ATP10A BMPR1B ADAMTS9 TACC1 PLXNA2	9.98e-07	193	175	8	01c2df9206f1527c578e808978e58196c35e72f5
ToppCell	10x5'v1-week_17-19-Endothelial\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	GALNT15 COL4A5 VWF SYNPO IGFBP4 ADAMTS9 NID1 TNKS1BP1	1.04e-06	194	175	8	e141beafc9252e5d8c949252bfab53e127c881dc
ToppCell	LV-10._Endothelium_II\|LV / Chamber and Cluster_Paper	VWF FN1 HIPK2 ATP10A ITGB4 ADAMTS9 TACC1 PLXNA2	1.04e-06	194	175	8	b6cc849fa08599bff9839ef382d190cc964e273e
ToppCell	10x5'v1-week_17-19-Endothelial-stroma\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	GALNT15 COL4A5 VWF SYNPO IGFBP4 ADAMTS9 NID1 TNKS1BP1	1.04e-06	194	175	8	953578102ffc7b612ee8fce45e414750800fef5d
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN ASH1L CYFIP2 NISCH NCOA1 BOD1L1 ST18 MAPK8IP2	1.08e-06	195	175	8	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWF COBLL1 ACE MSMP GGT5 IGFBP4 NID1 PLXNA2	1.16e-06	197	175	8	62c0a90869431e582bb7bb329e0b0cc59123d3d1
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWF COBLL1 ACE MSMP GGT5 IGFBP4 NID1 PLXNA2	1.16e-06	197	175	8	16f0eb047df9d702518f82ee99c6e7dc1350b2fb
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWF COBLL1 ACE ALS2CL ATP10A GGT5 NID1 PLXNA2	1.26e-06	199	175	8	236b1417ed0875e98c6ec1ec714003bfce438d65
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GALNT15 VWF COBLL1 CUBN ACE ATP10A MSMP GGT5	1.26e-06	199	175	8	c5c12c8288fe868322bae9d691b91fee953ceb3e
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWF FN1 COBLL1 ACE ATP10A GGT5 IGFBP4 NID1	1.26e-06	199	175	8	1295f34a350bf48987e2fad411aaac3630efd3f1
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma\|TCGA-Brain / Sample_Type by Project: Shred V9	ZNF438 SZT2 ERBIN ITGB4 ARHGEF10L BMPR1B KIF1C	3.67e-06	162	175	7	810881210e015c788814e4fe8d7a24c929cf2621
ToppCell	TCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-8\|TCGA-Thryoid / Sample_Type by Project: Shred V9	HIVEP1 NPAS3 SYNPO BICD1 ADAMTS9 TRAK2 SHISA6	4.66e-06	168	175	7	00646601548b0fee42ae16bfa5e93603bc7c5129
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VWF NADK2 NCSTN BICD1 SYT15 POLI DNMBP	5.65e-06	173	175	7	4968712af1cca8c932abd3323631d7dcaffd4a66
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ADGRG5 TUT4 RNF213 ICE1 ERBIN SYNE2 MYBL1	6.56e-06	177	175	7	d3e6c768b88b7906f3c7fdd00ba20842212c14b1
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ADGRG5 TUT4 RNF213 ICE1 ERBIN SYNE2 MYBL1	6.56e-06	177	175	7	f8f101c772c043636bedd6b2ec81409b1d2599bf
ToppCell	COVID-19_Mild-Lymphoid_T/NK-NK_activated\|COVID-19_Mild / Disease group, lineage and cell class	ADGRG5 TUT4 RNF213 ICE1 ERBIN SYNE2 MYBL1	6.56e-06	177	175	7	6978a22fef40c8b455342373abe7593f5ede0fa4
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	ADGRG5 TUT4 RNF213 ICE1 ERBIN SYNE2 MYBL1	6.56e-06	177	175	7	936ab2b180a052387124f68d0c7f41c0b164e748
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ADGRG5 TUT4 RNF213 ICE1 ERBIN SYNE2 MYBL1	6.56e-06	177	175	7	d5aeda113afaa2425874394610344570c9078478
ToppCell	LPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL4A5 SHROOM3 COBLL1 CXCL3 RNF43 SYNE2 AKAP1	7.06e-06	179	175	7	fd2cbee532e7b44113410dca82aec7db1a7fb69f
ToppCell	RA-07._Pericyte\|RA / Chamber and Cluster_Paper	HIPK2 ATP10A GGT5 ADAMTS12 ADAMTS9 NR1H4 SHISA6	7.59e-06	181	175	7	8dfb42d096db6c2df9b41303a7199d134d4bff07
ToppCell	Children_(3_yrs)-Immune-enucleated_erythrocyte-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL4A5 SPAG1 IL17RC CUBN PLA2R1 NR1H4 CDCA4	7.87e-06	182	175	7	3fddadb2ff75013ec6eeb415872667a6bae1da2d
ToppCell	RA-07._Pericyte\|World / Chamber and Cluster_Paper	FN1 HIPK2 ATP10A GGT5 ADAMTS9 TACC1 NR1H4	7.87e-06	182	175	7	2075efeae633550fb2eb026d0dfd741c8252482e
ToppCell	COVID-19_Mild-Lymphoid_T/NK-CD4+_T_activated\|COVID-19_Mild / Disease group, lineage and cell class	TUT4 ICE1 ALS2CL ERBIN RNF157 PCNX2 SYNE2	8.16e-06	183	175	7	7717fce227b4e02ed41baad8ae7dd2e22bd7c13e
ToppCell	COVID-19_Mild-gd_T\|COVID-19_Mild / Disease condition and Cell class	CACNA2D2 RNF213 ERBIN CYFIP2 SYNE2 SHISA6 MYBL1	8.16e-06	183	175	7	f593a89b0aa8fffdfa403769916facfd30358521
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	VWF CUBN ACE ITGB4 SYT15 IGFBP4 PLXNA2	8.45e-06	184	175	7	087666ba949b129c53d7ace40f9e543e3875a7de
ToppCell	wk_08-11-Hematologic-Myeloid-DC3\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	SIGLEC12 ADGRG5 LILRA1 SIGLEC9 SIGLEC14 IRF5 ITGAX	8.45e-06	184	175	7	7d9294e5a55964903feda135e5bea0338824ed83
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-5_PVALB_TRIM67\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B RELN CACNA2D2 NPAS3 COL25A1 ADAMTS9 MARCHF11	8.45e-06	184	175	7	7f6c8912677764d438ab0555faca344d74c2f483
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B RELN NPAS3 COL25A1 ADAMTS9 MARCHF11 SHISA6	9.07e-06	186	175	7	96f6603cc75fa1ffc2a2fdb94ec0ec09498e540a
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL4A5 SHROOM3 CXCL3 RNF43 CYFIP2 AKAP1 PLXNA2	9.07e-06	186	175	7	e83718fabb057100835d3357df407f283d23fe16
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A5 COBLL1 BICD1 BMPR1B B4GALNT2 AFF1 BCAR3	9.39e-06	187	175	7	e3095455d2f255854f339f6b05fa87852af0700f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A5 COBLL1 BICD1 BMPR1B B4GALNT2 AFF1 BCAR3	1.01e-05	189	175	7	3a295c215b5c18e7c673f92b7af5be523421682c
ToppCell	RA-10._Endothelium_II\|World / Chamber and Cluster_Paper	VWF FN1 HIPK2 BMPR1B ADAMTS9 TACC1 PLXNA2	1.01e-05	189	175	7	75c248b9de5e2fb7a0baa8cdbab516e575cc4394
ToppCell	RA-10._Endothelium_II\|RA / Chamber and Cluster_Paper	VWF FN1 HIPK2 BMPR1B ADAMTS9 TACC1 PLXNA2	1.01e-05	189	175	7	c81787a8c662db5d7814c583dd64562857629e81
ToppCell	LA-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	SHROOM3 FN1 COBLL1 ETV6 ATP10A ARHGEF10L KIF13A	1.01e-05	189	175	7	6b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCell	COVID-19-Heart-Mito_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GALNT15 XIRP1 VWF SYNPO IGFBP4 ADAMTS9 KIF1C	1.04e-05	190	175	7	ea74e0e38bcaba125b48c88331e9ba09228d3178
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RNF144B HIVEP1 SIGLEC14 ITGAX ERBIN ACOD1 ZNF697	1.08e-05	191	175	7	0b296404ebad0aadb75737f8c0462ec6934fc8bb
ToppCell	(1)_Osterolineage_cells-(10)_OLC-1\|(1)_Osterolineage_cells / Cell class and subclass of bone marrow stroma cells in homeostatis	EFEMP2 COL25A1 CYFIP2 GGT5 ADAMTS9 HP PLXNA2	1.08e-05	191	175	7	78ad7c555409ce1391bce406bc0f3ef575329ece
ToppCell	LPS_only-Epithelial_alveolar-AT_2-Differentiating_AT1\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL4A5 SHROOM3 CXCL3 RNF43 SYNE2 STRC	1.11e-05	127	175	6	5b0adbcafad31a6759c9bdce2f7f9591a8edc450
ToppCell	15-Trachea-Endothelial-Endothelial\|Trachea / Age, Tissue, Lineage and Cell class	GALNT15 RELN VWF FN1 SYNPO IGFBP4 NID1	1.15e-05	193	175	7	6ea0444fc3dc156997129387184e6418947f4b12
ToppCell	15-Trachea-Endothelial\|Trachea / Age, Tissue, Lineage and Cell class	GALNT15 RELN VWF FN1 SYNPO IGFBP4 NID1	1.15e-05	193	175	7	b1ebf8df2d55e2938e5a495ea68b80c4ac216dc0
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN ASH1L CYFIP2 NISCH NCOA1 BOD1L1 ST18	1.23e-05	195	175	7	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	COVID-19_Severe-Lymphoid_T/NK-gd_T\|COVID-19_Severe / Disease group, lineage and cell class	ADGRG5 CACNA2D2 RNF213 ERBIN CYFIP2 SYNE2 MYBL1	1.23e-05	195	175	7	9990440bda7fac5d00ef80444fab07459be625e1
ToppCell	PCW_13-14-Endothelial-Endothelial_mature\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	RNF144B VWF COBLL1 ACE ITGB4 IGFBP4 CD40	1.23e-05	195	175	7	31353269591c9eee84872838e91995d4a035da46
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	ADGRG5 CACNA2D2 RNF213 ERBIN CYFIP2 SYNE2 MYBL1	1.27e-05	196	175	7	418e8e0a51c5cb60e3b903e7d2d800dc8b9f3d5c
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ADGRG5 CACNA2D2 RNF213 ERBIN CYFIP2 SYNE2 MYBL1	1.27e-05	196	175	7	581fc8c8d42005aacd7b401a2c9d1fc331fb4af7
ToppCell	(6)_Endothelial_cells-(6)_Endothelial-B_(Artery)\|(6)_Endothelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	RNF144B FN1 EFEMP2 SYNPO CUBN CXCL3 PLXNA2	1.27e-05	196	175	7	f540cf17b4405a6dd38d2b6123e6541d0aac889e
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A5 SHROOM3 COBLL1 CYFIP2 ARHGEF10L MYO3B NR1H4	1.27e-05	196	175	7	6ce74aa3f0ce3ca284b67e5a4660ffd2cc9611e0
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ADGRG5 CACNA2D2 RNF213 ERBIN CYFIP2 SYNE2 MYBL1	1.27e-05	196	175	7	6beaf0c2799424c59819b286fbb5c1a83d85e4d1
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ADGRG5 CACNA2D2 RNF213 ERBIN CYFIP2 SYNE2 MYBL1	1.27e-05	196	175	7	c35f2349dfe35baa845f790b9f31673dceac54c0
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RNF144B LILRA1 SIGLEC9 SIGLEC14 ITGAX CXCL3 ACOD1	1.32e-05	197	175	7	59aa4a31674125ae422450aee45db3ced5c405d3
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-6_mon-Macroglial\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	SHROOM3 EFEMP2 NPAS3 ERBIN ZNF106 IGFBP4 LRIG1	1.32e-05	197	175	7	965d5a3f8c9b12cb8a8d3429702ae29ebd8c6122
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-6_mon-Macroglial-Astroglia\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	SHROOM3 EFEMP2 NPAS3 ERBIN ZNF106 IGFBP4 LRIG1	1.32e-05	197	175	7	3f088eb29197bc575400d6dafd8083e69e4a149f
ToppCell	Non-neuronal-Postmitotic-Mural\|World / Primary Cells by Cluster	VWF FN1 COBLL1 CXCL3 GGT5 CD40 NID1	1.36e-05	198	175	7	dd38840a96171f58da243daa22b013e15a81db4a
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWF FN1 ATP10A GGT5 NID1 TACC1 PLXNA2	1.36e-05	198	175	7	0a4626b51ba8b52acbaf616f0ced850079cd7149
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWF COBLL1 ACE GGT5 IGFBP4 NID1 PLXNA2	1.36e-05	198	175	7	e1fa02184ce93c4f8aa5cf04b70949cd4c425ff0
ToppCell	Non-neuronal-Postmitotic-Mural-Mural\|World / Primary Cells by Cluster	VWF FN1 COBLL1 CXCL3 GGT5 CD40 NID1	1.36e-05	198	175	7	9fc1035ea447a4551a66944c869c4671e17cec61
ToppCell	(11)_FOXN4+-(2)_GFP_FOXI1\|(11)_FOXN4+ / shred by cell type by condition	SHROOM3 HIPK2 ZNF106 SYNE2 TMF1 BOD1L1 TRAK2	1.36e-05	198	175	7	76d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCell	Non-neuronal-Postmitotic-Mural-Mural-18\|World / Primary Cells by Cluster	VWF FN1 COBLL1 CXCL3 GGT5 CD40 NID1	1.36e-05	198	175	7	21efb7bcd24f24d20791b34e75d6f9d46a129481
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWF ACE MSMP GGT5 IGFBP4 NID1 PLXNA2	1.41e-05	199	175	7	0602e2b2aa56d106da63bd342a38bef437b4d496
ToppCell	Non-neuronal-Postmitotic-Endothelial\|World / Primary Cells by Cluster	VWF FN1 COBLL1 ACE GGT5 IGFBP4 NID1	1.41e-05	199	175	7	b9763ac9857a60db6f1f104fe1e9ea2266cf931b
ToppCell	Non-neuronal-Postmitotic-Endothelial-Endothelial-24\|World / Primary Cells by Cluster	VWF FN1 COBLL1 ACE GGT5 IGFBP4 NID1	1.41e-05	199	175	7	0b4edf3e359749827ef978a77b5267ddde732d71
ToppCell	Non-neuronal-Postmitotic-Endothelial-Endothelial\|World / Primary Cells by Cluster	VWF FN1 COBLL1 ACE GGT5 IGFBP4 NID1	1.41e-05	199	175	7	9e01eee126247a0696c71b019f855a8a41a0ede3
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWF ACE MSMP GGT5 IGFBP4 NID1 PLXNA2	1.41e-05	199	175	7	463ba77dc4c85eebb343f29a42c7ac889b0497c9
ToppCell	Transverse-Monocyte\|Transverse / Region, Cell class and subclass	RNF144B LILRA1 SIGLEC9 SIGLEC14 ITGAX CXCL3 HP	1.45e-05	200	175	7	d70aeb57b98496474b97906505576640fdbdf34c
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWF COBLL1 ACE ATP10A GGT5 NID1 PLXNA2	1.45e-05	200	175	7	86ec951234015ced7126b016199e5869a0f22478
ToppCell	Sigmoid-(4)_Monocyte\|Sigmoid / shred on region, Cell_type, and subtype	RNF144B LILRA1 SIGLEC9 CXCL3 HP NID1 ZNF697	1.45e-05	200	175	7	7f3920a0434d5199c6c8f0b3064a305bb0d87b60
ToppCell	Sigmoid-Monocyte-Monocyte\|Sigmoid / Region, Cell class and subclass	RNF144B LILRA1 SIGLEC9 CXCL3 HP NID1 ZNF697	1.45e-05	200	175	7	010ca36970cb8894bdbca08779c0ecf56be22fc9
ToppCell	Sigmoid-Monocyte\|Sigmoid / Region, Cell class and subclass	RNF144B LILRA1 SIGLEC9 CXCL3 HP NID1 ZNF697	1.45e-05	200	175	7	c41bd6ec0f2262fce5cadb37a400d487e6662f49
ToppCell	Sigmoid-(4)_Monocyte-(40)_Monocyte\|Sigmoid / shred on region, Cell_type, and subtype	RNF144B LILRA1 SIGLEC9 CXCL3 HP NID1 ZNF697	1.45e-05	200	175	7	576c0a1098e6a934448705de3673ef798fcf1b26
ToppCell	Parenchymal-10x3prime_v2-Stromal-Peri/Epineurial_-NAF_epineurial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	INPP5F BICD1 ADAMTS12 PLA2R1 LRR1 AKAP1 PLPPR2	1.45e-05	200	175	7	be46efc899d06c55ee297bee3126f69bcdb2048b
ToppCell	Transverse-(4)_Monocyte\|Transverse / shred on region, Cell_type, and subtype	RNF144B LILRA1 SIGLEC9 SIGLEC14 ITGAX CXCL3 HP	1.45e-05	200	175	7	85714e8da539366b5bce071dfea8f8055de527bc
ToppCell	Transverse-Monocyte-Monocyte\|Transverse / Region, Cell class and subclass	RNF144B LILRA1 SIGLEC9 SIGLEC14 ITGAX CXCL3 HP	1.45e-05	200	175	7	96ecfab57e998134e164b4a62881ef6f2612bd8d
ToppCell	Transverse-(4)_Monocyte-(40)_Monocyte\|Transverse / shred on region, Cell_type, and subtype	RNF144B LILRA1 SIGLEC9 SIGLEC14 ITGAX CXCL3 HP	1.45e-05	200	175	7	0187a4b1d2c3c89b7769d632e6d88190a06b093e
ToppCell	LPS-IL1RA-Myeloid-Monocytes,_Macrophages-Neutrophils\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LILRA1 IRF5 ITGAX ITGB4 ARHGEF10L CCDC97	1.86e-05	139	175	6	505bf5a483fc2ba69377db9850c3b26ab2f416d1
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	BNIP5 SHROOM3 COBLL1 BMPR1B MARCHF11 DHX34	3.20e-05	153	175	6	9b6675ace8a83c8d446b722301d0ec4e6840f3fc
ToppCell	droplet-Lung-nan-3m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IRF5 ACE ITGAX CYFIP2 ARHGEF10L TMCC1	3.20e-05	153	175	6	6dcab3d50ab50051955204dc4e4a64c1ca855bcd
ToppCell	droplet-Lung-nan-3m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IRF5 ACE ITGAX CYFIP2 ARHGEF10L TMCC1	3.20e-05	153	175	6	f6ef14d949107c08cb3690e26ec91e194cb43518
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Rspo1_Itga4\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RNF144B NPAS3 INPP5F CSMD3 ST18 SHISA6	3.44e-05	155	175	6	cba6f3f7742b4d5d54ad0a0ac0dd4016e73fe658
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	BNIP5 SHROOM3 COBLL1 BMPR1B MARCHF11 DHX34	3.69e-05	157	175	6	2c5295043611bac7dfa4aef2146681bce4a33a8f
ToppCell	droplet-Lung-LUNG-1m-Myeloid-neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CXCL3 GGT5 ACOD1 HP TMCC1 HDC	3.83e-05	158	175	6	30cceb73cf5e24b692da84d33342fd3b1ad5efe5
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CXCL3 GGT5 ACOD1 HP TMCC1 HDC	3.83e-05	158	175	6	47793463640f98ee5f680a1ee5786b453355fd57
ToppCell	droplet-Lung-1m-Hematologic-myeloid-neutrophil-neutrophil\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CXCL3 GGT5 ACOD1 HP TMCC1 HDC	3.96e-05	159	175	6	be54b910ccb73e37eb81945bbad9a89d2bcec34b
ToppCell	droplet-Lung-1m-Hematologic-myeloid-neutrophil\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CXCL3 GGT5 ACOD1 HP TMCC1 HDC	3.96e-05	159	175	6	178678173b005cb8225472306657f0d8289b133b
ToppCell	droplet-Limb_Muscle-nan-24m-Myeloid-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL25A1 GPR179 HP ST18 IQGAP3 HDC	4.10e-05	160	175	6	984990be02642a562f0c60ea99c01f005e7c02c2
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ETV6 ACE ITGAX CYFIP2 ST18 IQGAP3	4.40e-05	162	175	6	93bd29c52846c3156b8b0d2e39c552373efdfe93
Drug	Levopropoxyphene napsylate [5714-90-9]; Down 200; 7.4uM; MCF7; HT_HG-U133A	COBLL1 ASH1L PHTF2 IRF5 NEK9 BICD1 PCNX2 KIF13A PLPPR2 PIGO	2.76e-06	199	171	10	3543_DN
Drug	AC1L1H6N	CACNA1B XIRP1 POLI	4.12e-06	5	171	3	CID000003999
Drug	AC1L9INI	COL4A5 FN1 SYNPO ITGB4 ZNF106 NID1	5.33e-06	59	171	6	CID000445839
Disease	autosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)	STRC STRCP1	3.30e-05	2	170	2	DOID:0110471 (implicated_via_orthology)
Disease	Malignant neoplasm of breast	ZNF438 XIRP1 VWF FN1 CUBN ALS2CL CXCL3 MAMDC4 PHKB HP NISCH SYNE2 CD40 NCOA1 AFF1 BOD1L1 BCAR3 SPOCD1	5.16e-05	1074	170	18	C0006142
Disease	revision of total hip arthroplasty	ICE1 ADAMTS12 STRCP1	6.53e-05	14	170	3	EFO_0020973
Disease	liver cirrhosis (is_marker_for)	RELN IRF5 ACE HP FUBP1	1.14e-04	82	170	5	DOID:5082 (is_marker_for)
Disease	thiopurine methyltransferase activity measurement	RNF144B KIF13A	1.96e-04	4	170	2	EFO_0007852
Disease	Colorectal Carcinoma	FN1 CUBN CSMD3 RNF43 ARHGEF10L ADAMTS15 B4GALNT2 ZNF624 NID1 KDM2A PLPPR2 PIGO HDC	2.29e-04	702	170	13	C0009402
Disease	urinary albumin to creatinine ratio	SHROOM3 CUBN MSTO1 PRKCI CCDC97 BAHCC1	6.18e-04	179	170	6	EFO_0007778
Disease	cholesterol:total lipids ratio, intermediate density lipoprotein measurement	SHROOM3 COBLL1 ZNF106 SYNE2 AFF1	6.94e-04	121	170	5	EFO_0008595, EFO_0020943
Disease	aspartate aminotransferase measurement	SHROOM3 CACNA2D2 COBLL1 HECTD4 RNF213 INPP5F CUBN ADAMTS12 TRAFD1 ADAMTS9 PRKCI CCDC97 DNMBP GABBR1	7.85e-04	904	170	14	EFO_0004736
Disease	triglycerides:total lipids ratio, intermediate density lipoprotein measurement	SHROOM3 COBLL1 ZNF106 SYNE2 AFF1	8.64e-04	127	170	5	EFO_0008595, EFO_0020947
Disease	sialic acid-binding Ig-like lectin 6 measurement	SIGLEC12 SIGLEC6	9.03e-04	8	170	2	EFO_0008285
Disease	sarcoidosis (is_marker_for)	ACE HP	9.03e-04	8	170	2	DOID:11335 (is_marker_for)
Disease	sialic acid-binding Ig-like lectin 9 measurement	SIGLEC12 SIGLEC9	1.16e-03	9	170	2	EFO_0008286
Disease	Focal Segmental Glomerulosclerosis, Not Otherwise Specified	COL4A5 SYNPO	1.16e-03	9	170	2	C4049702
Disease	renovascular hypertension (implicated_via_orthology)	FN1 ACE	1.16e-03	9	170	2	DOID:1591 (implicated_via_orthology)
Disease	Cardiovascular Diseases	VWF ACE HP	1.17e-03	36	170	3	C0007222
Disease	Focal glomerulosclerosis	COL4A5 FN1 SYNPO	1.17e-03	36	170	3	C0017668
Disease	obesity (implicated_via_orthology)	PNPLA5 ADAMTS9 HP CD40 NCOA1 PRKCI	1.59e-03	215	170	6	DOID:9970 (implicated_via_orthology)
Disease	end stage renal disease (is_implicated_in)	VWF ACE CD40	1.71e-03	41	170	3	DOID:783 (is_implicated_in)
Disease	triglycerides:total lipids ratio, low density lipoprotein cholesterol measurement	SHROOM3 COBLL1 ZNF106 SYNE2 AFF1	1.81e-03	150	170	5	EFO_0004611, EFO_0020947
Disease	very low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio	SHROOM3 COBLL1 CYP2W1 BSND ZNF106 SYNE2	1.87e-03	222	170	6	EFO_0008317, EFO_0020943
Disease	triglycerides in large LDL measurement	COBLL1 SYNE2 AFF1	1.96e-03	43	170	3	EFO_0022319
Disease	schizophrenia (is_marker_for)	RELN VWF ACE	2.09e-03	44	170	3	DOID:5419 (is_marker_for)
Disease	Alcohol Use Disorder	VWF ST18 GABBR1	2.09e-03	44	170	3	C0001956
Disease	sialic acid-binding Ig-like lectin 14 measurement	SIGLEC14 SIGLEC6	2.10e-03	12	170	2	EFO_0008284
Disease	nervous system disease (implicated_via_orthology)	ATP4A KIF1C	2.10e-03	12	170	2	DOID:863 (implicated_via_orthology)
Disease	papillary thyroid carcinoma	TRMO PCNX2	2.10e-03	12	170	2	EFO_0000641
Disease	Paroxysmal atrial fibrillation	VWF ACE LRIG1 SYNE2 IRF2BPL	2.15e-03	156	170	5	C0235480
Disease	familial atrial fibrillation	VWF ACE LRIG1 SYNE2 IRF2BPL	2.15e-03	156	170	5	C3468561
Disease	Persistent atrial fibrillation	VWF ACE LRIG1 SYNE2 IRF2BPL	2.15e-03	156	170	5	C2585653
Disease	albuminuria	SHROOM3 CUBN PRKCI BAHCC1	2.17e-03	94	170	4	EFO_0004285
Disease	end stage renal disease (is_marker_for)	VWF FN1 CD40	2.38e-03	46	170	3	DOID:783 (is_marker_for)
Disease	Atrial Fibrillation	VWF ACE LRIG1 SYNE2 IRF2BPL	2.39e-03	160	170	5	C0004238
Disease	juvenile polyposis syndrome (implicated_via_orthology)	HIVEP1 BMPR1B	2.47e-03	13	170	2	DOID:0050787 (implicated_via_orthology)
Disease	leukemia (is_implicated_in)	ETV6 ACE	2.47e-03	13	170	2	DOID:1240 (is_implicated_in)
Disease	Adenoid Cystic Carcinoma	ERBIN ITGB4 PRKDC MYBL1	2.71e-03	100	170	4	C0010606
Disease	cholestasis (biomarker_via_orthology)	ACE HP NR1H4	2.85e-03	49	170	3	DOID:13580 (biomarker_via_orthology)
Disease	trimethylamine-N-oxide measurement	CUBN ST18	2.87e-03	14	170	2	EFO_0010541
Disease	atrial fibrillation (is_implicated_in)	VWF ACE	2.87e-03	14	170	2	DOID:0060224 (is_implicated_in)
Disease	cholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement	COBLL1 ZNF106 SYNE2 AFF1	3.02e-03	103	170	4	EFO_0008595, EFO_0020944
Disease	hair colour measurement	SHROOM3 TRMO ATP10A ADAMTS12 ZNF469 SYNE2 TACC1 ASXL2 BCAR3 AKAP1	3.12e-03	615	170	10	EFO_0007822
Disease	Proteinuria	VWF CUBN	3.30e-03	15	170	2	HP_0000093
Disease	Familial thoracic aortic aneurysm and aortic dissection	COL4A5 EFEMP2 ADAMTS10	3.56e-03	53	170	3	C4707243
Disease	Intrahepatic cholestasis of pregnancy	SHROOM3 ATP4A	3.76e-03	16	170	2	EFO_0009048
Disease	Metastatic melanoma	BMPR1B PRKCI PRKDC	3.76e-03	54	170	3	C0278883
Disease	triglyceride measurement, intermediate density lipoprotein measurement	SHROOM3 COBLL1 SYNE2 AFF1	3.95e-03	111	170	4	EFO_0004530, EFO_0008595
Disease	hepatocellular carcinoma (is_implicated_in)	RAD52 ACE RNF43 FUBP1 NR1H4	4.06e-03	181	170	5	DOID:684 (is_implicated_in)
Disease	Autistic Disorder	KDM5B RELN ACE CSMD3 ATP10A GABBR1	4.15e-03	261	170	6	C0004352
Disease	triglycerides in LDL measurement	COBLL1 SYNE2 AFF1	4.16e-03	56	170	3	EFO_0022320
Disease	sphingomyelin 14:0 measurement	SYNE2 NID1	4.24e-03	17	170	2	EFO_0010390
Disease	Alzheimer's disease (implicated_via_orthology)	HIVEP1 NCSTN ACE	4.38e-03	57	170	3	DOID:10652 (implicated_via_orthology)
Disease	very low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio	COBLL1 HECTD4 CYP2W1 BSND ZNF106 SYNE2	4.39e-03	264	170	6	EFO_0008317, EFO_0020944
Disease	Drug habituation	ETV6 CSMD3 PLA2R1 BCAR3	4.48e-03	115	170	4	C0013170
Disease	Drug abuse	ETV6 CSMD3 PLA2R1 BCAR3	4.48e-03	115	170	4	C0013146
Disease	Prescription Drug Abuse	ETV6 CSMD3 PLA2R1 BCAR3	4.48e-03	115	170	4	C4316881
Disease	Substance-Related Disorders	ETV6 CSMD3 PLA2R1 BCAR3	4.48e-03	115	170	4	C0236969
Disease	Drug Use Disorders	ETV6 CSMD3 PLA2R1 BCAR3	4.48e-03	115	170	4	C0013222
Disease	Drug Dependence	ETV6 CSMD3 PLA2R1 BCAR3	4.48e-03	115	170	4	C1510472
Disease	Substance Dependence	ETV6 CSMD3 PLA2R1 BCAR3	4.48e-03	115	170	4	C0038580
Disease	Substance Use Disorders	ETV6 CSMD3 PLA2R1 BCAR3	4.48e-03	115	170	4	C0038586
Disease	Organic Mental Disorders, Substance-Induced	ETV6 CSMD3 PLA2R1 BCAR3	4.48e-03	115	170	4	C0029231
Disease	Substance abuse problem	ETV6 CSMD3 PLA2R1 BCAR3	4.62e-03	116	170	4	C0740858
Disease	serum alanine aminotransferase measurement	GALNT15 SHROOM3 COBLL1 HECTD4 ETV6 CYFIP2 TRAFD1 ADAMTS9 PISD CCDC97 DNMBP GABBR1	4.67e-03	869	170	12	EFO_0004735
Disease	non-alcoholic steatohepatitis (is_marker_for)	IRF5 NR1H4	4.75e-03	18	170	2	DOID:0080547 (is_marker_for)
Disease	adenosine monophosphate measurement	CSMD3 AKAP1	4.75e-03	18	170	2	EFO_0010454
Disease	waist-hip ratio	FN1 DCUN1D5 COBLL1 HECTD4 PHTF2 INKA2 RNF157 ADAMTS10 BMPR1B ADAMTS9 NISCH MYO3B SYNE2 NID1 SHISA6	5.00e-03	1226	170	15	EFO_0004343
Disease	Sjogren syndrome	RELN IRF5 NCOA1	5.05e-03	60	170	3	EFO_0000699
Disease	basophil measurement	ZNF469 AFF1 HDC	5.05e-03	60	170	3	EFO_0803539
Disease	Schizophrenia	CACNA1B RELN NPAS3 AMBRA1 CSMD2 ACE ALS2CL ADAMTS12 HP PLA2G4B PLXNA2 GABBR1	5.28e-03	883	170	12	C0036341
Disease	bipolar disorder (is_marker_for)	RELN VWF	5.29e-03	19	170	2	DOID:3312 (is_marker_for)
Disease	type 1 diabetes mellitus (biomarker_via_orthology)	VWF HP	5.29e-03	19	170	2	DOID:9744 (biomarker_via_orthology)
Disease	factor VIII measurement, Ischemic stroke	VWF HECTD4	5.29e-03	19	170	2	EFO_0004630, HP_0002140
Disease	triglycerides to total lipids in very large HDL percentage	COBLL1 CD40 AFF1	5.54e-03	62	170	3	EFO_0022339

Protein segments in the cluster

Peptide	Gene	Start	Entry
CSPTGNHVNEILESP	TACC1	441	O75410
CTPAHRLLQDSQDVP	ALS2CL	226	Q60I27
DHCRPVSEVSTLQPL	MAMDC4	421	Q6UXC1
QSPNRTEPHDSDCSV	ERBIN	831	Q96RT1
LPTSSQDCARPGHQD	BAHCC1	496	Q9P281
LQTHPPCRRSESSGI	AKAP1	96	Q92667
CESPDAHQPGAERNL	ARHGEF10L	136	Q9HCE6
EPQSTCTPEERRHNQ	ASH1L	2906	Q9NR48
QLAGRQDCPTVSPDT	BICD1	936	Q96G01
TLQSDHCLDPGIPVN	CSMD2	861	Q7Z408
EPTQTSCENPGVPRH	CSMD3	3346	Q7Z407
HSDGPEQCELVQRPR	CACNA2D2	1076	Q9NY47
EQPTCSNADSRAHPL	C8orf33	46	Q9H7E9
PEHRNSVPCQDPITG	ALDH16A1	51	Q8IZ83
GICPPVTRNETHFDA	ACE	501	P12821
GSCPEVIIGHQSRSP	B4GALNT2	511	Q8NHY0
LHEGRESTCVPPNNV	BCAR3	691	O75815
RHPTSEQPSCQQIVS	CCNJ	291	Q5T5M9
LPHVPRCTAADTQLG	CYP2W1	361	Q8TAV3
CTPVSTSPHLLVDQN	DNMBP	616	Q6XZF7
NSDQATPCHLRSPET	LINC01600	101	Q96MT4
PSAEGPTLHCELTNN	AMBRA1	1261	Q9C0C7
GSDFQCRDTPIPHQR	BMPR1B	76	O00238
QPREPHCDLETSGTV	CACNA1B	1021	Q00975
AQRPRGTHLCSTTPD	CACNA1B	2026	Q00975
TVPGRPVEVSCAHTN	DMXL1	1041	Q9Y485
VPQDLAHIQERPASC	COBLL1	306	Q53SF7
NIQSVNVRSPGPHCA	CXCL3	56	P19876
NVRSPGPHCAQTEVI	CXCL3	61	P19876
CRSQPPARLISGEEH	DCUN1D5	31	Q9BTE7
ASVSHPQGPSSCRQE	ASXL2	816	Q76L83
HTQQPVCSLEASGEP	ATP10A	1356	O60312
QASHECTEALRPPTT	ADAMTS10	1036	Q9H324
QPHRSCNINEDSGLP	ADAMTS12	371	P58397
GQRTVPACDAAHRPV	ADAMTS15	871	Q8TE58
SRPSHAVIPADQDCS	RAD52	226	P43351
VEVSHPQNPSLRCSS	ITGAX	986	P20702
QGPLHSNETDRLPRC	NCSTN	606	Q92542
QGLENPIQISPHCSC	NR1H4	6	Q96RI1
HAEVSCRDSQPIVLP	RNF144B	161	Q7Z419
SQHCTSQPSPRVGNL	HDC	476	P19113
NHEEDNCVQRTPRPS	ETV6	151	P41212
VTIECGRHSLPQEPV	PRKCI	186	P41743
EAQHSQRSPPRCSQE	LILRA4	466	P59901
LENHCTGNPRTIIVP	HIPK2	956	Q9H2X6
SPVGVQPILNEHTFC	HP	326	P00738
GIQPLCPERSHISDQ	TMPO	336	P42166
ARLECAATGHPNPQI	LRIG1	616	Q96JA1
HSCLDQDPEQRPTAD	NEK9	286	Q8TD19
RTQPHQSCAQQGPER	INKA2	121	Q9NTI7
QQESVCPRESTVPGH	GPR179	1531	Q6PRD1
HRGCNVDTPVSTLTP	LRR1	111	Q96L50
VNTDPERSEGHLCLP	NADK2	181	Q4G0N4
RIAQITGPPDRCQHA	FUBP1	321	Q96AE4
TGPPDRCQHAAEIIT	FUBP1	326	Q96AE4
QTPNATSEGCQIIHP	GABBR1	21	Q9UBS5
SLGRSEQPHPICSFQ	MAPK8IP2	61	Q13387
CGFPSQPHTNENREI	FSIP2	3341	Q5CZC0
CLQQHPQDSLPTASV	GALNT15	181	Q8N3T1
PVCSQQQGEPDLTEH	CCDC97	76	Q96F63
EPHRINPGECLATSE	C9orf131	526	Q5VYM1
VKPTHSRPEGGCQEV	FAM90A22	226	A8MWA6
RLEDTHFVQCPSVPS	IRF2BPL	721	Q9H1B7
CEPPDATEQGQLHDR	PCNX2	2086	A6NKB5
ETQLLCEPPNLTGQH	PLXNA2	1196	O75051
IDRACHTSQLTPGTP	MSTO1	421	Q9BUK6
QECVHDDSRPALPST	NID1	616	P14543
RSEDPTPAEQHCART	COL25A1	16	Q9BXS0
EQHCLFRSIPQPDGE	KIF1C	541	O43896
HDIPQRQSVQPSETC	KDM5B	211	Q9UGL1
ASAHDSCPNPIQREV	IRF5	351	Q13568
SPEEQLQPRECHTFS	PLA2G4B	671	P0C869
DSSTVEHVRCFQPPI	CYFIP2	1256	Q96F07
HGPPCRIAAVATAQQ	HECTD4	2186	Q9Y4D8
VSCRTHQEVPSEPGR	ITGB4	1211	P16144
PGCPLNTSHLTREEI	IQGAP3	696	Q86VI3
QLCEQGAPTDVTVHP	RELN	176	P78509
VTCVVHNFQSRPPSG	PLPPR2	281	Q96GM1
ETAQRQCPETEPHDT	BOD1L1	2796	Q8NFC6
LPELSGPFTHTRQCV	CUBN	721	O60494
APQREPSTGRHACDT	ADAMTS9	211	Q9P2N4
NTLHLQSEPPECSIG	ICE1	681	Q9Y2F5
LVQHCPARTPQRGDE	KDM2A	836	Q9Y2K7
HDREEACSPQQEPQG	BSND	216	Q8WZ55
QEEVGVENPAPHCRR	BNIP5	416	P0C671
LPPRASISHVTCVDQ	C2CD2L	131	O14523
EGRLDTSVQTPCPQH	LINC00322	46	Q6ZN03
SCHPVGTDEEPLQFR	FN1	2226	P02751
NPADPISHCNRSEDL	CENPJ	626	Q9HC77
RHSQTTDAPQCPQGT	COL4A5	1466	P29400
DPPQRDEFLGTCVQH	FASTKD1	586	Q53R41
AVVLSRHQAPCGPQA	GGT5	26	P36269
LVHPTQLTSPRFQCG	MARCHF11	356	A6NNE9
LEAFQVSHPCRQPDT	GSTZ1	196	O43708
ACQTPNFVRGLHSEP	MALSU1	51	Q96EH3
HCSNISNVPPTREIL	ASNSD1	256	Q9NWL6
GITVPSFHECQINRP	ACOD1	346	A6NK06
TGVCHLRLEPPDTSQ	FAM47A	406	Q5JRC9
GCHSSSQRPEVQKPR	LCE6A	41	A0A183
SRQHNCGTPLPVSSE	EXOC1	561	Q9NV70
ELVSHRSPGEPQETC	C1orf127	436	Q8N9H9
ASNPLCREQPSSIVH	EFEMP2	331	O95967
LERIAHENTCPQAPQ	DHX34	1081	Q14147
GRESRQCPIPSHVIQ	POLI	381	Q9UNA4
PPLTVRLHTQSVSEC	PWWP2B	466	Q6NUJ5
TPPQESTCVDDIHPR	INPP5F	261	Q9Y2H2
GATQHQELLETCPPT	POLRMT	676	O00411
GESEPQTRSPECTHE	ATP4A	231	P20648
VSPEGNCIEHVQPTS	MYBL1	236	P10243
CEEPRAQSPFTHITT	CREB3L2	86	Q70SY1
LERLVGPQDATHCSP	IL17RC	21	Q8NAC3
QDPRPTTCLHSVFNV	PHKB	141	Q93100
FLVTPAQVQGRCPEH	P2RX6	116	O15547
PRRNKEGCTSETPHA	KIF13A	1436	Q9H1H9
VHGCPQLSRGTPVDE	KIF13B	1231	Q9NQT8
PQSCRHFQSPDLGTQ	SZT2	3346	Q5T011
AQSHRVSCEVEPPGS	RGL2	501	O15211
DGIQNHEPQCETIRP	PHTF2	291	Q8N3S3
AQHLQAPSETCSPLV	SYT15	171	Q9BQS2
SQRPSVQHLGEECGV	RNF157	461	Q96PX1
IDHQTSCNPSRALPS	TRAFD1	306	O14545
RGESEEPSSPQSLCH	SYNE2	6381	Q8WXH0
DTIPNRVTDHTCPSG	TADA2B	126	Q86TJ2
TNEIRPVSSCTPQHI	LINC00869	151	P0C866
EDEHPQCLNSQPRTH	LILRA1	161	O75019
NIQATSPCLHPTDLQ	CMAS	141	Q8NFW8
SVQQDPLSRHPPETC	SPATA31A6	296	Q5VVP1
DDSACRVTQGTPQLP	SYNPO	66	Q8N3V7
QPPSCSREEQGASQH	SYNPO	86	Q8N3V7
VCPEQINDPALRHTG	NCOA1	1351	Q15788
GTVDICPQSTSPNLH	PNPLA5	191	Q7Z6Z6
GSRPQDATVHPACQI	RNF43	666	Q68DV7
TITPRPQDHSTNLTC	SIGLEC6	201	O43699
IPQPQDHGTSLTCQV	SIGLEC9	201	Q9Y336
GPPSRNVIESATVCH	SHPRH	1216	Q149N8
SVPSECPGTLDHQRQ	SHROOM3	1311	Q8TF72
CPGTLDHQRQASRTP	SHROOM3	1316	Q8TF72
QQGPIPIAHCERETI	SHISA6	221	Q6ZSJ9
HQEQSCGPPSRLQAS	SPATA31E1	636	Q6ZUB1
ERITAQHPLPNQSEC	NPAS3	16	Q8IXF0
ARPVPQGSCQSELHR	IGFBP4	166	P22692
PQPQDHGTSLTCQVT	SIGLEC12	331	Q96PQ1
FLQGAICHVPPETRQ	PLA2R1	1226	Q13018
VQHVCQGPTPDVTAS	STRC	501	Q7RTU9
PQTGQCPDQAHRTSL	ST18	456	O60284
PEGCRTEQPSHSQVL	ADGRG5	206	Q8IZF4
CGPPDSQHLTQDRLG	AFF1	151	P51825
VSDLCPVTSAQAPRH	CDCA4	126	Q9BXL8
ERCDPESVISQSHPS	ZBTB25	206	P24278
PHSTPQGIISTFRQC	RNF213	2811	Q63HN8
CRILHPSDITQVTPS	TRAK2	676	O60296
PEPGIATEELHSRCQ	ZNF624	211	Q9P2J8
SGRSATPVNCEQPDI	TMF1	396	P82094
RQLSGCDEPQPHHST	TRMO	201	Q9BU70
VCHPLRSLQQPGQST	AVPR1B	136	P47901
PDQCHTVTCQPDGQT	VWF	1896	P04275
SQHPIDFPAGCEVRQ	MSMP	81	Q1L6U9
QPQCPECHESLGLTQ	SPEM3	656	A0A1B0GUW6
STGDPVLSPQHNCEL	SPOCD1	11	Q6ZMY3
QARPVCGLHSVISPS	PISD	176	Q9UG56
DNLPPVRGSNSCLHV	SPAG1	126	Q07617
SPCHSQLLEAQTPEA	TNKS1BP1	311	Q9C0C2
TDSLTPEHQPIAQGC	NISCH	526	Q9Y2I1
PEHQPIAQGCSDSLE	NISCH	531	Q9Y2I1
QNACAEIDGVPTHPT	TMCC1	86	O94876
QNPSLPGECHSRSDS	TTLL6	756	Q8N841
NPVVEFVSHPSTTCR	PRKDC	2456	P78527
PHCTGISQQDPESDS	ZC2HC1C	86	Q53FD0
VTHPIRGCELPSNHQ	ZNF469	3506	Q96JG9
PQDSRHREAVPDICT	ZNF697	61	Q5TEC3
IGCDRQNAPHITATP	TRIM49D1	311	C9J1S8
TRLELTNHSSCQEPP	PIGO	31	Q8TEQ8
VQHVCQGPTPDVTAS	STRCP1	501	A6NGW2
LHFQCPSDVETRPQS	ZNF286B	106	P0CG31
ELSPPCSEQHNREQI	TUT4	961	Q5TAX3
DPTCTHIVVGHPLRN	TOPBP1	1301	Q92547
LPCHSPSRSDQVNLG	ZNF438	51	Q7Z4V0
HVFETEPLQASGRPC	XIRP1	661	Q702N8
EPSEHPDQVPCSLTR	ZNF106	1121	Q9H2Y7
LPNQVISDPVGTDHC	HIVEP1	1581	P15822
TPRPEDHGTNLTCQV	SIGLEC14	201	Q08ET2
NTAAPVQETLHGCQP	CD40	246	P25942
SVPGDPVRIHCNITE	UBE2Q1	96	Q7Z7E8
SERGCSPSPNLVTHQ	ZFP3	91	Q96NJ6
QDQCHTPGFPTSRET	nan	11	Q96M85
LSSRICHPAPDQQGL	MYO3B	1221	Q8WXR4
CDHQQNSPTLERPGR	NMNAT1	111	Q9HAN9