Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmolecular adaptor activity

DVL2 DVL3 NCOA3 KMT2C KMT2D SNAP91 RBM33 SPPL2C SF1 EP300

1.73e-0513563010GO:0060090
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

DVL2 DVL3 NCOA3 KMT2C KMT2D SNAP91 RBM33 SF1 EP300

3.44e-051160309GO:0030674
GeneOntologyMolecularFunctionhistone H3K4 monomethyltransferase activity

KMT2C KMT2D

6.08e-058302GO:0140945
GeneOntologyMolecularFunctionhistone H3K4 trimethyltransferase activity

KMT2C KMT2D

9.75e-0510302GO:0140999
GeneOntologyMolecularFunctionhistone modifying activity

NCOA3 KMT2C KMT2D EP300

3.65e-04229304GO:0140993
GeneOntologyMolecularFunctionhistone H3K4 methyltransferase activity

KMT2C KMT2D

4.08e-0420302GO:0042800
GeneOntologyMolecularFunctionperoxisome proliferator activated receptor binding

NCOA3 EP300

4.50e-0421302GO:0042975
GeneOntologyMolecularFunctiontranscription coactivator activity

NCOA3 KMT2C KMT2D EP300

1.04e-03303304GO:0003713
GeneOntologyMolecularFunctionnuclear androgen receptor binding

NCOA3 EP300

1.12e-0333302GO:0050681
GeneOntologyMolecularFunctiontranscription coregulator activity

NCOA3 KMT2C KMT2D SF1 EP300

1.38e-03562305GO:0003712
GeneOntologyMolecularFunctionfrizzled binding

DVL2 DVL3

1.81e-0342302GO:0005109
GeneOntologyMolecularFunctionhistone H3 methyltransferase activity

KMT2C KMT2D

1.98e-0344302GO:0140938
GeneOntologyMolecularFunctionhistone acetyltransferase activity

NCOA3 EP300

2.66e-0351302GO:0004402
GeneOntologyMolecularFunctionnuclear receptor binding

NCOA3 RARG EP300

2.72e-03187303GO:0016922
GeneOntologyMolecularFunctionpeptide-lysine-N-acetyltransferase activity

NCOA3 EP300

3.08e-0355302GO:0061733
GeneOntologyMolecularFunctionpeptide N-acetyltransferase activity

NCOA3 EP300

3.66e-0360302GO:0034212
GeneOntologyMolecularFunctionpre-mRNA binding

SNRPC EP300

4.15e-0364302GO:0036002
GeneOntologyMolecularFunctionchromatin binding

NCOA3 CHD6 RARG ONECUT1 EP300

4.52e-03739305GO:0003682
GeneOntologyMolecularFunctionprotein-lysine N-methyltransferase activity

KMT2C KMT2D

4.67e-0368302GO:0016279
GeneOntologyMolecularFunctionlysine N-methyltransferase activity

KMT2C KMT2D

4.81e-0369302GO:0016278
GeneOntologyMolecularFunctiontranscription factor binding

NCOA3 CHD6 RARG EP300 MEIS2

4.90e-03753305GO:0008134
GeneOntologyMolecularFunctionhistone methyltransferase activity

KMT2C KMT2D

5.08e-0371302GO:0042054
GeneOntologyMolecularFunctionN-acetyltransferase activity

NCOA3 EP300

6.10e-0378302GO:0008080
GeneOntologyMolecularFunctionDNA-binding transcription activator activity, RNA polymerase II-specific

NCOA3 KMT2D ONECUT1 MEIS2

9.40e-03560304GO:0001228
GeneOntologyMolecularFunctionDNA-binding transcription activator activity

NCOA3 KMT2D ONECUT1 MEIS2

9.75e-03566304GO:0001216
GeneOntologyMolecularFunctionN-acyltransferase activity

NCOA3 EP300

1.02e-02102302GO:0016410
GeneOntologyMolecularFunctionprotein methyltransferase activity

KMT2C KMT2D

1.04e-02103302GO:0008276
GeneOntologyMolecularFunctionacetyltransferase activity

NCOA3 EP300

1.06e-02104302GO:0016407
GeneOntologyMolecularFunctionN-methyltransferase activity

KMT2C KMT2D

1.08e-02105302GO:0008170
GeneOntologyMolecularFunctionbeta-catenin binding

DVL3 EP300

1.40e-02120302GO:0008013
GeneOntologyBiologicalProcessmRNA splicing, via spliceosome

RBM25 PRPF40B SNRPC PRPF40A SF1 MBNL1

8.89e-06358296GO:0000398
GeneOntologyBiologicalProcessRNA splicing, via transesterification reactions with bulged adenosine as nucleophile

RBM25 PRPF40B SNRPC PRPF40A SF1 MBNL1

8.89e-06358296GO:0000377
GeneOntologyBiologicalProcessRNA splicing, via transesterification reactions

RBM25 PRPF40B SNRPC PRPF40A SF1 MBNL1

9.47e-06362296GO:0000375
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase II

DVL2 DVL3 NCOA3 KMT2C CHD6 KMT2D RARG ONECUT1 EP300 MEIS2

1.15e-0513902910GO:0045944
GeneOntologyBiologicalProcessmRNA cis splicing, via spliceosome

PRPF40B SNRPC PRPF40A

3.89e-0547293GO:0045292
GeneOntologyBiologicalProcessmRNA splice site recognition

SNRPC SF1 MBNL1

5.27e-0552293GO:0006376
GeneOntologyBiologicalProcesspositive regulation of neuron projection arborization

DVL2 DVL3

5.32e-058292GO:0150012
GeneOntologyBiologicalProcessRNA splicing

RBM25 PRPF40B SNRPC PRPF40A SF1 MBNL1

5.95e-05502296GO:0008380
GeneOntologyBiologicalProcesscochlea development

DVL2 DVL3 SOBP

8.51e-0561293GO:0090102
GeneOntologyBiologicalProcessmRNA processing

RBM25 PRPF40B SNRPC PRPF40A SF1 MBNL1

9.95e-05551296GO:0006397
GeneOntologyBiologicalProcessembryo development

DVL2 DVL3 NCOA3 KMT2D RARG SOBP EP300 MEIS2 MBNL1

1.05e-041437299GO:0009790
GeneOntologyBiologicalProcesspositive regulation of intracellular estrogen receptor signaling pathway

NCOA3 KMT2D

1.25e-0412292GO:0033148
GeneOntologyBiologicalProcessnuclear receptor-mediated signaling pathway

NCOA3 KMT2D RARG EP300

1.75e-04202294GO:0141193
GeneOntologyBiologicalProcessregulation of establishment of planar polarity involved in neural tube closure

DVL2 DVL3

1.98e-0415292GO:0090178
GeneOntologyBiologicalProcessregulation of neuron projection arborization

DVL2 DVL3

1.98e-0415292GO:0150011
GeneOntologyBiologicalProcesschordate embryonic development

DVL2 DVL3 NCOA3 KMT2D RARG EP300 MBNL1

2.06e-04906297GO:0043009
GeneOntologyBiologicalProcessmRNA metabolic process

RBM25 PRPF40B SNRPC RBM33 PRPF40A SF1 MBNL1

2.22e-04917297GO:0016071
GeneOntologyBiologicalProcessestablishment of planar polarity involved in neural tube closure

DVL2 DVL3

2.26e-0416292GO:0090177
GeneOntologyBiologicalProcessembryo development ending in birth or egg hatching

DVL2 DVL3 NCOA3 KMT2D RARG EP300 MBNL1

2.40e-04929297GO:0009792
GeneOntologyBiologicalProcessregulation of intracellular steroid hormone receptor signaling pathway

NCOA3 KMT2D EP300

2.45e-0487293GO:0033143
GeneOntologyBiologicalProcessestablishment of planar polarity of embryonic epithelium

DVL2 DVL3

2.88e-0418292GO:0042249
GeneOntologyBiologicalProcesspositive regulation of intracellular steroid hormone receptor signaling pathway

NCOA3 KMT2D

2.88e-0418292GO:0033145
GeneOntologyBiologicalProcessregulation of establishment of planar polarity

DVL2 DVL3

3.22e-0419292GO:0090175
GeneOntologyBiologicalProcessspliceosomal complex assembly

SNRPC SF1 MBNL1

3.58e-0499293GO:0000245
GeneOntologyBiologicalProcesshormone-mediated signaling pathway

NCOA3 KMT2D RARG EP300

3.60e-04244294GO:0009755
GeneOntologyBiologicalProcessmulticellular organism growth

NCOA3 KMT2C RARG EP300

3.88e-04249294GO:0035264
GeneOntologyBiologicalProcessembryonic morphogenesis

DVL2 DVL3 NCOA3 RARG SOBP MBNL1

4.02e-04713296GO:0048598
GeneOntologyBiologicalProcesssensory organ development

DVL2 DVL3 KMT2C RARG SOBP MEIS2

4.55e-04730296GO:0007423
GeneOntologyBiologicalProcessneural tube closure

DVL2 DVL3 RARG

5.27e-04113293GO:0001843
GeneOntologyBiologicalProcesspositive regulation of axonogenesis

IST1 SNAP91 EP300

5.41e-04114293GO:0050772
GeneOntologyBiologicalProcesstube closure

DVL2 DVL3 RARG

5.41e-04114293GO:0060606
GeneOntologyBiologicalProcesspositive regulation of cell projection organization

DVL2 DVL3 IST1 SNAP91 EP300

5.70e-04494295GO:0031346
GeneOntologyBiologicalProcessprimary neural tube formation

DVL2 DVL3 RARG

6.28e-04120293GO:0014020
GeneOntologyBiologicalProcesscochlea morphogenesis

DVL2 DVL3

7.57e-0429292GO:0090103
GeneOntologyBiologicalProcessregulation of mRNA splicing, via spliceosome

RBM25 SF1 MBNL1

7.75e-04129293GO:0048024
GeneOntologyBiologicalProcessinner ear morphogenesis

DVL2 DVL3 SOBP

7.75e-04129293GO:0042472
GeneOntologyBiologicalProcessdevelopmental cell growth

IST1 KMT2D RARG EP300

7.92e-04301294GO:0048588
GeneOntologyBiologicalProcessneural tube formation

DVL2 DVL3 RARG

8.66e-04134293GO:0001841
GeneOntologyBiologicalProcessnuclear receptor-mediated steroid hormone signaling pathway

NCOA3 KMT2D EP300

9.04e-04136293GO:0030518
GeneOntologyBiologicalProcessembryonic organ development

DVL2 DVL3 NCOA3 RARG SOBP

1.01e-03561295GO:0048568
GeneOntologyBiologicalProcessregulation of intracellular estrogen receptor signaling pathway

NCOA3 KMT2D

1.17e-0336292GO:0033146
GeneOntologyBiologicalProcesssensory organ morphogenesis

DVL2 DVL3 RARG SOBP

1.28e-03343294GO:0090596
GeneOntologyBiologicalProcessear morphogenesis

DVL2 DVL3 SOBP

1.29e-03154293GO:0042471
GeneOntologyBiologicalProcessneuron projection arborization

DVL2 DVL3

1.30e-0338292GO:0140058
GeneOntologyBiologicalProcesssteroid hormone receptor signaling pathway

NCOA3 KMT2D EP300

1.32e-03155293GO:0043401
GeneOntologyBiologicalProcessregulation of mRNA processing

RBM25 SF1 MBNL1

1.39e-03158293GO:0050684
GeneOntologyBiologicalProcessembryonic organ morphogenesis

DVL2 DVL3 RARG SOBP

1.40e-03351294GO:0048562
GeneOntologyBiologicalProcessembryonic epithelial tube formation

DVL2 DVL3 RARG

1.42e-03159293GO:0001838
GeneOntologyBiologicalProcesspositive regulation of neurogenesis

IST1 SNAP91 EP300 NCAN

1.44e-03354294GO:0050769
GeneOntologyBiologicalProcessdevelopmental growth

IST1 NCOA3 KMT2C KMT2D RARG EP300

1.45e-03911296GO:0048589
GeneOntologyBiologicalProcessanimal organ morphogenesis

DVL2 DVL3 NCOA3 RARG SOBP EP300 MEIS2

1.55e-031269297GO:0009887
GeneOntologyBiologicalProcesscell growth

IST1 NCOA3 KMT2D RARG EP300

1.63e-03625295GO:0016049
GeneOntologyBiologicalProcessregulation of nervous system development

IST1 RARG SNAP91 EP300 NCAN

1.63e-03625295GO:0051960
GeneOntologyBiologicalProcessestablishment of planar polarity

DVL2 DVL3

1.74e-0344292GO:0001736
GeneOntologyBiologicalProcessepithelial tube formation

DVL2 DVL3 RARG

1.80e-03173293GO:0072175
GeneOntologyBiologicalProcessestablishment of tissue polarity

DVL2 DVL3

1.82e-0345292GO:0007164
GeneOntologyBiologicalProcesstube formation

DVL2 DVL3 RARG

2.25e-03187293GO:0035148
GeneOntologyBiologicalProcessmorphogenesis of embryonic epithelium

DVL2 DVL3 RARG

2.36e-03190293GO:0016331
GeneOntologyBiologicalProcessregulation of axonogenesis

IST1 SNAP91 EP300

2.43e-03192293GO:0050770
GeneOntologyBiologicalProcessintracellular receptor signaling pathway

NCOA3 KMT2D RARG EP300

2.60e-03416294GO:0030522
GeneOntologyBiologicalProcesspositive regulation of nervous system development

IST1 SNAP91 EP300 NCAN

2.64e-03418294GO:0051962
GeneOntologyBiologicalProcessWnt signaling pathway, planar cell polarity pathway

DVL2 DVL3

2.71e-0355292GO:0060071
GeneOntologyBiologicalProcessepithelial tube morphogenesis

DVL2 DVL3 NCOA3 RARG

2.71e-03421294GO:0060562
GeneOntologyBiologicalProcessneural tube development

DVL2 DVL3 RARG

2.80e-03202293GO:0021915
GeneOntologyBiologicalProcessestrogen receptor signaling pathway

NCOA3 KMT2D

2.90e-0357292GO:0030520
GeneOntologyBiologicalProcessregulation of RNA splicing

RBM25 SF1 MBNL1

3.00e-03207293GO:0043484
GeneOntologyBiologicalProcessregulation of alternative mRNA splicing, via spliceosome

RBM25 MBNL1

3.11e-0359292GO:0000381
GeneOntologyBiologicalProcesspositive regulation of cell growth

IST1 NCOA3 EP300

3.25e-03213293GO:0030307
GeneOntologyBiologicalProcessregulation of mRNA metabolic process

RBM25 RBM33 SF1 MBNL1

3.26e-03443294GO:1903311
GeneOntologyBiologicalProcesschromatin remodeling

NCOA3 KMT2C CHD6 KMT2D EP300

3.42e-03741295GO:0006338
GeneOntologyBiologicalProcessface development

RARG EP300

3.53e-0363292GO:0060324
GeneOntologyBiologicalProcessregulation of anatomical structure morphogenesis

DVL2 DVL3 IST1 SNAP91 PRPF40A EP300

3.58e-031090296GO:0022603
GeneOntologyBiologicalProcessregulation of cell development

IST1 RARG SNAP91 EP300 MEIS2 NCAN

3.66e-031095296GO:0060284
GeneOntologyCellularComponentU2-type prespliceosome

PRPF40B SNRPC PRPF40A

2.15e-0618303GO:0071004
GeneOntologyCellularComponentprespliceosome

PRPF40B SNRPC PRPF40A

2.15e-0618303GO:0071010
GeneOntologyCellularComponentU1 snRNP

PRPF40B SNRPC PRPF40A

1.41e-0533303GO:0005685
GeneOntologyCellularComponentMLL3/4 complex

KMT2C KMT2D

1.30e-0412302GO:0044666
GeneOntologyCellularComponentspliceosomal complex

PRPF40B SNRPC PRPF40A SF1

2.42e-04215304GO:0005681
GeneOntologyCellularComponentspliceosomal snRNP complex

PRPF40B SNRPC PRPF40A

3.48e-0496303GO:0097525
GeneOntologyCellularComponentU2-type spliceosomal complex

PRPF40B SNRPC PRPF40A

3.59e-0497303GO:0005684
GeneOntologyCellularComponentsmall nuclear ribonucleoprotein complex

PRPF40B SNRPC PRPF40A

4.79e-04107303GO:0030532
GeneOntologyCellularComponentSm-like protein family complex

PRPF40B SNRPC PRPF40A

6.53e-04119303GO:0120114
GeneOntologyCellularComponentchromatin

DVL3 IST1 NCOA3 CHD6 RARG ONECUT1 EP300 MEIS2

8.87e-041480308GO:0000785
GeneOntologyCellularComponentclathrin adaptor complex

SYNRG SNAP91

9.02e-0431302GO:0030131
GeneOntologyCellularComponentclathrin vesicle coat

SYNRG SNAP91

1.36e-0338302GO:0030125
GeneOntologyCellularComponentnuclear body

DVL2 RBM25 PRPF40B SNRPC PRPF40A SF1

1.56e-03903306GO:0016604
GeneOntologyCellularComponentAP-type membrane coat adaptor complex

SYNRG SNAP91

2.16e-0348302GO:0030119
GeneOntologyCellularComponentnuclear protein-containing complex

NCOA3 KMT2C KMT2D PRPF40B SNRPC PRPF40A SF1

2.82e-031377307GO:0140513
GeneOntologyCellularComponentclathrin coat

SYNRG SNAP91

2.92e-0356302GO:0030118
GeneOntologyCellularComponentGolgi-associated vesicle membrane

SYNRG SPPL2C

3.46e-0361302GO:0030660
GeneOntologyCellularComponentvesicle coat

SYNRG SNAP91

4.15e-0367302GO:0030120
GeneOntologyCellularComponentclathrin-coated vesicle

DVL2 SYNRG SNAP91

4.66e-03237303GO:0030136
GeneOntologyCellularComponenthistone methyltransferase complex

KMT2C KMT2D

5.18e-0375302GO:0035097
HumanPhenoSupernumerary tooth

DVL3 KMT2C CHD6 KMT2D EP300

2.35e-088575HP:0011069
HumanPhenoNatal tooth

KMT2C CHD6 KMT2D EP300

9.07e-083874HP:0000695
HumanPhenoAdvanced eruption of teeth

KMT2C CHD6 KMT2D EP300

2.00e-074674HP:0006288
HumanPhenoAbnormality of the dentition

DVL3 KMT2C CHD6 KMT2D SOBP EP300 MEIS2

1.36e-05103077HP:0000164
HumanPhenoHigh, narrow palate

DVL3 CHD6 KMT2D EP300

2.76e-0515674HP:0002705
HumanPhenoHypoplastic heart

DVL3 KMT2D EP300

3.83e-055473HP:0001961
HumanPhenoAbnormal midface morphology

DVL3 KMT2C CHD6 KMT2D SOBP EP300

4.23e-0570476HP:0000309
HumanPhenoPilomatrixoma

KMT2D EP300

5.80e-05972HP:0030434
HumanPhenoAbnormal number of teeth

DVL3 KMT2C CHD6 KMT2D EP300

6.88e-0542175HP:0006483
HumanPhenoNarrow palate

DVL3 CHD6 KMT2D EP300

7.65e-0520274HP:0000189
HumanPhenoBroad hallux

KMT2D EP300 MEIS2

1.07e-047673HP:0010055
HumanPhenoVesicoureteral reflux

DVL3 KMT2C KMT2D EP300

1.09e-0422174HP:0000076
HumanPhenoAbnormality of dental eruption

KMT2C CHD6 KMT2D EP300

1.50e-0424074HP:0006292
HumanPhenoBroad toe

KMT2D EP300 MEIS2

1.60e-048773HP:0001837
HumanPhenoAbnormal ureter physiology

DVL3 KMT2C KMT2D EP300

1.63e-0424574HP:0025634
HumanPhenoAbnormal 5th finger morphology

DVL3 CHD6 KMT2D EP300 MEIS2

1.73e-0450975HP:0004207
HumanPhenoBroad thumb

DVL3 EP300 MEIS2

1.77e-049073HP:0011304
HumanPhenoConvex nasal ridge

CHD6 EP300 MEIS2

2.08e-049573HP:0000444
HumanPhenoAbnormal nasal dorsum morphology

CHD6 KMT2D EP300 MEIS2

2.12e-0426274HP:0011119
HumanPhenoPremature thelarche

KMT2D EP300

2.18e-041772HP:0010314
HumanPhenoAplasia/hypoplasia involving bones of the hand

DVL3 CHD6 KMT2D EP300 MEIS2

2.26e-0453875HP:0005927
HumanPhenoSkin appendage neoplasm

KMT2D EP300

2.45e-041872HP:0012842
HumanPhenoAbnormal eyelash morphology

DVL3 CHD6 KMT2D EP300

2.90e-0428474HP:0000499
HumanPhenoAplasia/hypoplasia involving bones of the upper limbs

DVL3 CHD6 KMT2D EP300 MEIS2

3.04e-0457275HP:0006496
HumanPhenoShort phalanx of finger

DVL3 KMT2D EP300 MEIS2

3.87e-0430674HP:0009803
HumanPhenoAgenesis of permanent teeth

DVL3 EP300

4.04e-042372HP:0006349
HumanPhenoInguinal hernia

DVL3 KMT2C KMT2D MEIS2

4.17e-0431274HP:0000023
HumanPhenoAplasia/Hypoplasia of the phalanges of the hand

DVL3 KMT2D EP300 MEIS2

4.54e-0431974HP:0009767
HumanPhenoLong eyelashes

DVL3 KMT2D EP300

5.16e-0412973HP:0000527
HumanPhenoPerimembranous ventricular septal defect

EP300 MEIS2

5.18e-042672HP:0011682
HumanPhenoCleft palate

DVL3 KMT2C KMT2D EP300 MEIS2

5.33e-0464375HP:0000175
HumanPhenoAbnormal hard palate morphology

DVL3 KMT2C KMT2D EP300 MEIS2

5.49e-0464775HP:0100737
HumanPhenoPatent foramen ovale

DVL3 KMT2D EP300

5.89e-0413573HP:0001655
HumanPhenoAbnormal earlobe morphology

KMT2C KMT2D EP300

6.15e-0413773HP:0000363
HumanPhenoShort columella

KMT2D EP300

6.46e-042972HP:0002000
HumanPhenoAbnormal testis morphology

DVL3 KMT2C CHD6 KMT2D EP300 MEIS2

6.66e-04112976HP:0000035
HumanPhenoAbnormal eyebrow morphology

KMT2C CHD6 KMT2D EP300 MEIS2

6.67e-0467475HP:0000534
HumanPhenoNon-obstructive azoospermia

DVL3 KMT2C CHD6 KMT2D EP300 MEIS2

6.76e-04113276HP:0011961
HumanPhenoAbnormality of calvarial morphology

DVL3 KMT2C CHD6 KMT2D EP300 MEIS2

6.83e-04113476HP:0002648
HumanPhenoAvascular necrosis of the capital femoral epiphysis

DVL3 EP300

6.91e-043072HP:0005743
HumanPhenoCraniofacial cleft

DVL3 KMT2C KMT2D EP300 MEIS2

7.67e-0469475HP:5201015
HumanPhenoOrofacial cleft

DVL3 KMT2C KMT2D EP300 MEIS2

7.67e-0469475HP:0000202
HumanPhenoAzoospermia

DVL3 KMT2C CHD6 KMT2D EP300 MEIS2

7.67e-04115776HP:0000027
HumanPhenoBroad phalanx

DVL3 EP300 MEIS2

7.72e-0414873HP:0006009
HumanPhenoBroad phalanges of the hand

DVL3 EP300 MEIS2

7.72e-0414873HP:0009768
HumanPhenoCoarctation of aorta

KMT2D EP300 MEIS2

8.03e-0415073HP:0001680
HumanPhenoSparse eyebrow

CHD6 KMT2D MEIS2

8.19e-0415173HP:0045075
HumanPhenoProportionate short stature

DVL3 CHD6 KMT2D

8.51e-0415373HP:0003508
HumanPhenoBroad finger

DVL3 EP300 MEIS2

8.67e-0415473HP:0001500
HumanPhenoDental malocclusion

DVL3 KMT2D EP300

9.01e-0415673HP:0000689
HumanPhenoAbnormal spermatogenesis

DVL3 KMT2C CHD6 KMT2D EP300 MEIS2

9.02e-04119076HP:0008669
HumanPhenoAbnormality of the ureter

DVL3 KMT2C KMT2D EP300

9.17e-0438374HP:0000069
HumanPhenoBroad long bones

DVL3 EP300 MEIS2

9.18e-0415773HP:0005622
HumanPhenoAbnormal number of permanent teeth

DVL3 EP300

9.43e-043572HP:0011044
HumanPhenoAbnormal palate morphology

DVL3 KMT2C CHD6 KMT2D EP300 MEIS2

9.56e-04120276HP:0000174
HumanPhenoHydrocele testis

KMT2D EP300

9.97e-043672HP:0000034
HumanPhenoNasolacrimal duct obstruction

KMT2D EP300

9.97e-043672HP:0000579
HumanPhenoFrontal bossing

DVL3 CHD6 KMT2D EP300 MEIS2

1.03e-0373875HP:0002007
HumanPhenoAbnormal shape of the frontal region

DVL3 CHD6 KMT2D EP300 MEIS2

1.05e-0374175HP:0011218
HumanPhenoAbnormal frontal bone morphology

DVL3 CHD6 KMT2D EP300 MEIS2

1.05e-0374275HP:0430000
HumanPhenoAbnormal male internal genitalia morphology

DVL3 KMT2C CHD6 KMT2D EP300 MEIS2

1.16e-03124376HP:0000022
HumanPhenoCapillary hemangioma

DVL3 EP300

1.17e-033972HP:0005306
HumanPhenoAplasia involving bones of the extremities

DVL3 CHD6 KMT2D EP300 MEIS2

1.17e-0375975HP:0009825
HumanPhenoAplasia/hypoplasia involving bones of the extremities

DVL3 CHD6 KMT2D EP300 MEIS2

1.19e-0376175HP:0045060
HumanPhenoTelecanthus

DVL3 CHD6 KMT2D

1.22e-0317373HP:0000506
HumanPhenoAbnormal calvaria morphology

DVL3 KMT2C CHD6 KMT2D EP300 MEIS2

1.22e-03125476HP:0002683
HumanPhenoTooth malposition

DVL3 KMT2D SOBP EP300

1.28e-0341874HP:0000692
HumanPhenoClinodactyly of the 5th finger

DVL3 CHD6 KMT2D EP300

1.30e-0342074HP:0004209
HumanPhenoFunctional abnormality of male internal genitalia

DVL3 KMT2C CHD6 KMT2D EP300 MEIS2

1.31e-03126976HP:0000025
HumanPhenoClinodactyly of hands

DVL3 CHD6 KMT2D EP300

1.32e-0342174HP:0001157
HumanPhenoDeviation of the 5th finger

DVL3 CHD6 KMT2D EP300

1.32e-0342174HP:0009179
HumanPhenoJuvenile aseptic necrosis

DVL3 EP300

1.42e-034372HP:0100323
HumanPhenoBrachydactyly (hand)

DVL3 KMT2D EP300 MEIS2

1.43e-0343074HP:0100667
HumanPhenoCleft upper lip

DVL3 KMT2D MEIS2

1.43e-0318373HP:0000204
HumanPhenoAbnormal heart morphology

DVL3 KMT2D EP300

1.46e-0318473HP:3000001
HumanPhenoSmooth philtrum

KMT2D EP300 MEIS2

1.48e-0318573HP:0000319
HumanPhenoPrecocious puberty

KMT2C KMT2D EP300

1.50e-0318673HP:0000826
HumanPhenoEarly onset of sexual maturation

KMT2C KMT2D EP300

1.58e-0318973HP:0100000
HumanPhenoAbnormal male reproductive system physiology

DVL3 KMT2C CHD6 KMT2D EP300 MEIS2

1.59e-03131476HP:0012874
HumanPhenoAplasia/hypoplasia of the extremities

DVL3 CHD6 KMT2D EP300 MEIS2

1.62e-0381375HP:0009815
HumanPhenoFlared metaphysis

DVL3 EP300 MEIS2

1.62e-0319173HP:0003015
HumanPhenoProminent fingertip pads

KMT2D EP300

1.63e-034672HP:0001212
HumanPhenoSecundum atrial septal defect

KMT2D MEIS2

1.63e-034672HP:0001684
HumanPhenoRadial deviation of finger

DVL3 CHD6 KMT2D EP300

1.67e-0344874HP:0009466
HumanPhenoAbnormal thorax morphology

DVL3 KMT2C CHD6 KMT2D EP300 MEIS2

1.69e-03132876HP:0000765
HumanPhenoAbnormal male external genitalia morphology

DVL3 KMT2C CHD6 KMT2D EP300 MEIS2

1.70e-03132976HP:0000032
HumanPhenoFinger clinodactyly

DVL3 CHD6 KMT2D EP300

1.72e-0345274HP:0040019
HumanPhenoChiari type I malformation

KMT2D EP300

1.77e-034872HP:0007099
HumanPhenoProminent digit pad

KMT2D EP300

1.77e-034872HP:0011298
HumanPhenoRadial deviation of the hand or of fingers of the hand

DVL3 CHD6 KMT2D EP300

1.78e-0345674HP:0009485
HumanPhenoHypoplastic left heart

KMT2D EP300

1.85e-034972HP:0004383
HumanPhenoTracheomalacia

KMT2C CHD6

1.85e-034972HP:0002779
HumanPhenoAbnormal lacrimal duct morphology

KMT2D EP300

1.92e-035072HP:0011481
HumanPhenoAbnormality of thumb phalanx

DVL3 EP300 MEIS2

1.99e-0320573HP:0009602
HumanPhenoCongenital malformation of the left heart

KMT2D EP300

2.00e-035172HP:0045017
HumanPhenoHighly arched eyebrow

KMT2D EP300 MEIS2

2.02e-0320673HP:0002553
HumanPhenoAbnormal external genitalia

DVL3 KMT2C CHD6 KMT2D EP300 MEIS2

2.04e-03137276HP:0000811
HumanPhenoAbnormal finger morphology

DVL3 KMT2C CHD6 KMT2D EP300 MEIS2

2.15e-03138576HP:0001167
HumanPhenoAbnormal hallux morphology

KMT2D EP300 MEIS2

2.20e-0321273HP:0001844
DomainBAT2_N

PRRC2A PRRC2C

6.98e-063292IPR009738
DomainBAT2_N

PRRC2A PRRC2C

6.98e-063292PF07001
DomainDsh_C

DVL2 DVL3

6.98e-063292PF12316
DomainPRRC2

PRRC2A PRRC2C

6.98e-063292IPR033184
DomainDishevelled_C-dom

DVL2 DVL3

6.98e-063292IPR024580
DomainDishevelled

DVL2 DVL3

1.39e-054292PF02377
Domain-

PRPF40B PRPF40A

1.39e-0542921.10.10.440
DomainDsh/Dvl-rel

DVL2 DVL3

1.39e-054292IPR015506
DomainDishevelled_protein_dom

DVL2 DVL3

1.39e-054292IPR003351
DomainDishevelled_fam

DVL2 DVL3

1.39e-054292IPR008339
DomainFYrich_C

KMT2C KMT2D

2.32e-055292IPR003889
DomainFYrich_N

KMT2C KMT2D

2.32e-055292IPR003888
DomainFYRC

KMT2C KMT2D

2.32e-055292SM00542
DomainFYRN

KMT2C KMT2D

2.32e-055292SM00541
DomainFYRN

KMT2C KMT2D

2.32e-055292PF05964
DomainFYRC

KMT2C KMT2D

2.32e-055292PF05965
DomainFYRC

KMT2C KMT2D

2.32e-055292PS51543
DomainFYRN

KMT2C KMT2D

2.32e-055292PS51542
DomainFF

PRPF40B PRPF40A

3.48e-056292PF01846
DomainFF

PRPF40B PRPF40A

3.48e-056292SM00441
DomainNuc_rcpt_coact

NCOA3 EP300

3.48e-056292IPR009110
DomainFF

PRPF40B PRPF40A

3.48e-056292PS51676
DomainFF_domain

PRPF40B PRPF40A

3.48e-056292IPR002713
DomainDIX

DVL2 DVL3

4.87e-057292IPR001158
DomainDIX

DVL2 DVL3

4.87e-057292PS50841
DomainDAX

DVL2 DVL3

4.87e-057292SM00021
DomainDIX

DVL2 DVL3

4.87e-057292PF00778
DomainPost-SET_dom

KMT2C KMT2D

2.76e-0416292IPR003616
DomainPostSET

KMT2C KMT2D

2.76e-0416292SM00508
DomainPOST_SET

KMT2C KMT2D

2.76e-0416292PS50868
DomainDEP

DVL2 DVL3

5.27e-0422292PF00610
DomainEPHD

KMT2C KMT2D

5.27e-0422292PS51805
DomainDEP

DVL2 DVL3

5.27e-0422292SM00049
DomainDEP

DVL2 DVL3

5.27e-0422292PS50186
DomainDEP_dom

DVL2 DVL3

5.77e-0423292IPR000591
DomainSET

KMT2C KMT2D

1.84e-0341292PF00856
DomainSET

KMT2C KMT2D

2.31e-0346292SM00317
DomainWW

PRPF40B PRPF40A

2.41e-0347292PF00397
DomainWW

PRPF40B PRPF40A

2.51e-0348292SM00456
DomainSET_dom

KMT2C KMT2D

2.72e-0350292IPR001214
DomainSET

KMT2C KMT2D

2.72e-0350292PS50280
DomainWW_DOMAIN_2

PRPF40B PRPF40A

2.83e-0351292PS50020
DomainWW_DOMAIN_1

PRPF40B PRPF40A

2.83e-0351292PS01159
DomainWW_dom

PRPF40B PRPF40A

2.94e-0352292IPR001202
DomainHMG_box

KMT2C KMT2D

3.05e-0353292PF00505
DomainHMG

KMT2C KMT2D

3.17e-0354292SM00398
DomainRRM

RBM25 RBM33 ENOX2

4.52e-03217293SM00360
DomainHMG_box_dom

KMT2C KMT2D

4.56e-0365292IPR009071
DomainRRM_dom

RBM25 RBM33 ENOX2

5.13e-03227293IPR000504
DomainRRM

RBM25 RBM33 ENOX2

5.32e-03230293PS50102
PathwayREACTOME_ACTIVATION_OF_ANTERIOR_HOX_GENES_IN_HINDBRAIN_DEVELOPMENT_DURING_EARLY_EMBRYOGENESIS

NCOA3 KMT2C KMT2D RARG EP300

1.67e-06122245M29689
PathwayPID_BETA_CATENIN_DEG_PATHWAY

DVL2 DVL3 SSPOP

3.48e-0618243M31
PathwayWP_MRNA_PROCESSING

RBM25 PRPF40B SNRPC RBM33 PRPF40A MBNL1 ENOX2

7.07e-06451247MM15946
PathwayPID_RETINOIC_ACID_PATHWAY

NCOA3 RARG EP300

1.71e-0530243M207
PathwayREACTOME_NEGATIVE_REGULATION_OF_TCF_DEPENDENT_SIGNALING_BY_DVL_INTERACTING_PROTEINS

DVL2 DVL3

2.77e-055242M27447
PathwayKEGG_SPLICEOSOME

RBM25 PRPF40B SNRPC PRPF40A

5.81e-05127244M2044
PathwayKEGG_NOTCH_SIGNALING_PATHWAY

DVL2 DVL3 EP300

6.69e-0547243M7946
PathwayREACTOME_WNT_MEDIATED_ACTIVATION_OF_DVL

DVL2 DVL3

7.73e-058242M27100
PathwayREACTOME_WNT_MEDIATED_ACTIVATION_OF_DVL

DVL2 DVL3

9.93e-059242MM14792
PathwayREACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT

DVL2 DVL3 KMT2D EP300

1.36e-04158244MM14791
PathwayREACTOME_KILLING_MECHANISMS

DVL2 DVL3

1.81e-0412242M29844
PathwayPID_BETA_CATENIN_NUC_PATHWAY

DVL3 SSPOP EP300

3.27e-0480243M223
PathwayREACTOME_REGULATION_OF_GENE_EXPRESSION_IN_LATE_STAGE_BRANCHING_MORPHOGENESIS_PANCREATIC_BUD_PRECURSOR_CELLS

ONECUT1 EP300

3.29e-0416242M27121
PathwayKEGG_MEDICUS_REFERENCE_WNT5A_ROR_SIGNALING_PATHWAY

DVL2 DVL3

3.29e-0416242M47823
PathwayREACTOME_MRNA_SPLICING

RBM25 SNRPC PRPF40A SF1

3.41e-04201244MM15411
PathwayREACTOME_MRNA_SPLICING

RBM25 SNRPC PRPF40A SF1

4.17e-04212244M14033
PathwayPID_WNT_CANONICAL_PATHWAY

DVL2 DVL3

5.18e-0420242M90
PathwayREACTOME_RUNX1_REGULATES_GENES_INVOLVED_IN_MEGAKARYOCYTE_DIFFERENTIATION_AND_PLATELET_FUNCTION

KMT2C KMT2D EP300

5.58e-0496243M27792
PathwayREACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT

DVL2 DVL3 KMT2D EP300

5.96e-04233244M27099
PathwayBIOCARTA_VDR_PATHWAY

NCOA3 EP300

6.28e-0422242MM1370
PathwayKEGG_MELANOGENESIS

DVL2 DVL3 EP300

6.48e-04101243M7761
PathwayWP_WNT_SIGNALING_PATHWAY_AND_PLURIPOTENCY

DVL2 DVL3 EP300

6.48e-04101243MM15829
PathwayWP_WNT_SIGNALING_AND_PLURIPOTENCY

DVL2 DVL3 EP300

6.48e-04101243M39387
PathwayREACTOME_SIGNALING_BY_WNT

DVL2 DVL3 KMT2D EP300

6.56e-04239244MM14756
PathwayWP_WNT_SIGNALING_PATHWAY

DVL2 DVL3 EP300

8.30e-04110243MM15977
PathwayREACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX

KMT2D EP300

8.81e-0426242MM14793
PathwayREACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA

RBM25 SNRPC PRPF40A SF1

1.14e-03277244MM15414
PathwayREACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA

RBM25 SNRPC PRPF40A SF1

1.23e-03283244M13087
PathwayREACTOME_DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUITMENT_OF_AXIN_TO_THE_MEMBRANE

DVL2 DVL3

1.25e-0331242M27400
PathwayREACTOME_DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUITMENT_OF_AXIN_TO_THE_MEMBRANE

DVL2 DVL3

1.25e-0331242MM15154
PathwayPID_WNT_NONCANONICAL_PATHWAY

DVL2 DVL3

1.34e-0332242M23
PathwayWP_TYPE_2_PAPILLARY_RENAL_CELL_CARCINOMA

DVL2 EP300

1.51e-0334242M39771
PathwayWP_WNT_SIGNALING_IN_KIDNEY_DISEASE

DVL2 DVL3

1.69e-0336242M39699
PathwayKEGG_MEDICUS_VARIANT_FZD7_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY

DVL2 DVL3

1.78e-0337242M47411
PathwayKEGG_WNT_SIGNALING_PATHWAY

DVL2 DVL3 EP300

2.07e-03151243M19428
PathwayPID_FOXM1_PATHWAY

ONECUT1 EP300

2.08e-0340242M176
PathwayREACTOME_SIGNALING_BY_WNT

DVL2 DVL3 KMT2D EP300

2.16e-03330244M7847
PathwayWP_BREAST_CANCER_PATHWAY

DVL2 DVL3 NCOA3

2.19e-03154243M39739
PathwayREACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT

ONECUT1 EP300

2.29e-0342242M17541
PathwayREACTOME_FORMATION_OF_WDR5_CONTAINING_HISTONE_MODIFYING_COMPLEXES

KMT2C KMT2D

2.29e-0342242M48018
PathwayPID_HNF3A_PATHWAY

NCOA3 EP300

2.52e-0344242M285
PathwayWP_WNT_SIGNALING_IN_KIDNEY_DISEASE

DVL2 DVL3

2.52e-0344242MM15878
PathwayREACTOME_RUNX1_REGULATES_GENES_INVOLVED_IN_MEGAKARYOCYTE_DIFFERENTIATION_AND_PLATELET_FUNCTION

KMT2D EP300

2.52e-0344242MM15527
PathwayWP_NOTCH_SIGNALING_WP268

DVL2 DVL3

2.63e-0345242M39571
PathwayKEGG_MEDICUS_VARIANT_LRP6_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY

DVL2 DVL3

2.63e-0345242M47412
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_PATHWAY

DVL2 DVL3

2.75e-0346242M47409
PathwayWP_NOTCH_SIGNALING_PATHWAY

DVL2 DVL3

2.75e-0346242MM15971
PathwayWP_WNT_SIGNALING_WP363

DVL2 DVL3

3.37e-0351242M39721
PathwayPID_TAP63_PATHWAY

SSPOP EP300

3.77e-0354242M256
PathwayKEGG_BASAL_CELL_CARCINOMA

DVL2 DVL3

3.90e-0355242M17807
PathwayREACTOME_DEGRADATION_OF_DVL

DVL2 DVL3

3.90e-0355242MM15153
PathwayREACTOME_DEGRADATION_OF_DVL

DVL2 DVL3

4.19e-0357242M27399
PathwayPID_NOTCH_PATHWAY

SSPOP EP300

4.48e-0359242M17
PathwayWP_WNT_SIGNALING

DVL2 DVL3

4.78e-0361242MM15893
PathwayPID_ERA_GENOMIC_PATHWAY

NCOA3 EP300

5.25e-0364242M200
PathwayWP_HISTONE_MODIFICATIONS

KMT2C KMT2D

5.41e-0365242M39374
PathwayWP_PATHWAYS_AFFECTED_IN_ADENOID_CYSTIC_CARCINOMA

KMT2C EP300

5.41e-0365242M39682
PathwayPID_HDAC_CLASSI_PATHWAY

SSPOP EP300

5.58e-0366242M101
PathwayREACTOME_PKMTS_METHYLATE_HISTONE_LYSINES

KMT2C KMT2D

6.25e-0370242M27231
Pubmed

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.

NCOA3 KMT2C KMT2D PRPF40B SNRPC RBM33 PRPF40A PRRC2C EP300 MBNL1

3.31e-12457301032344865
Pubmed

Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.

DVL2 RBM25 SNRPC RBM33 PRPF40A PRRC2A PRRC2C SF1 MEIS2

3.64e-1139930935987950
Pubmed

Human transcription factor protein interaction networks.

NCOA3 KMT2C CHD6 RBM25 KMT2D SMAP2 RBM33 SOBP PRPF40A PRRC2A PRRC2C EP300 MBNL1

5.62e-111429301335140242
Pubmed

MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis.

KMT2C KMT2D EP300

2.32e-09430328398509
Pubmed

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.

NCOA3 SNRPC RBM33 SOBP SF1 EP300

3.44e-0915230638360978
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

SYNRG KMT2C RBM25 KMT2D PRPF40A PRRC2A PRRC2C EP300

1.58e-0854930838280479
Pubmed

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.

NCOA3 KMT2C RBM25 KMT2D PRPF40A EP300

3.13e-0822030635785414
Pubmed

Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor.

NCOA3 SNRPC RBM33 SF1 EP300

4.42e-0811330523403292
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

RBM25 SNAP91 SNRPC RBM33 PRPF40A PRRC2A PRRC2C SF1 MBNL1

7.22e-0895430936373674
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

DVL3 SYNRG SMAP2 RBM33 PRRC2A PRRC2C SF1 MBNL1

1.32e-0772430836232890
Pubmed

New nomenclature for chromatin-modifying enzymes.

NCOA3 KMT2C KMT2D EP300

1.72e-075730418022353
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

NCOA3 KMT2C KMT2D RBM33 PRRC2A PRRC2C SF1 EP300 MBNL1

2.47e-07110330934189442
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

RBM25 SNRPC RBM33 PRPF40A PRRC2A PRRC2C SF1 MBNL1

3.02e-0780730822681889
Pubmed

Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation.

KMT2C KMT2D

7.19e-07230228483418
Pubmed

Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation.

KMT2C KMT2D

7.19e-07230236869380
Pubmed

Genetic analysis of disheveled 2 and disheveled 3 in human neural tube defects.

DVL2 DVL3

7.19e-07230222892949
Pubmed

Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability.

KMT2C KMT2D

7.19e-07230228967912
Pubmed

The MLL3/4 H3K4 methyltransferase complex in establishing an active enhancer landscape.

KMT2C KMT2D

7.19e-07230234156443
Pubmed

Planar polarization of node cells determines the rotational axis of node cilia.

DVL2 DVL3

7.19e-07230220098415
Pubmed

Crucial roles of mixed-lineage leukemia 3 and 4 as epigenetic switches of the hepatic circadian clock controlling bile acid homeostasis in mice.

KMT2C KMT2D

7.19e-07230225346535
Pubmed

Homeodomain proteins: an update.

ONECUT1 MEIS2

7.19e-07230226464018
Pubmed

KMT2C/D COMPASS complex-associated diseases [KCDCOM-ADs]: an emerging class of congenital regulopathies.

KMT2C KMT2D

7.19e-07230231924266
Pubmed

Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal Adenocarcinoma.

KMT2C KMT2D

7.19e-07230227280393
Pubmed

Disheveled proteins promote cell growth and tumorigenicity in ALK-positive anaplastic large cell lymphoma.

DVL2 DVL3

7.19e-07230223022960
Pubmed

Association of KMT2C/D loss-of-function variants with response to immune checkpoint blockades in colorectal cancer.

KMT2C KMT2D

7.19e-07230236601880
Pubmed

Dishevelled-3 C-terminal His single amino acid repeats are obligate for Wnt5a activation of non-canonical signaling.

DVL2 DVL3

2.16e-06330221092292
Pubmed

Dishevelled stability is positively regulated by PKCζ-mediated phosphorylation induced by Wnt agonists.

DVL2 DVL3

2.16e-06330228366812
Pubmed

Prp40 pre-mRNA processing factor 40 homolog B (PRPF40B) associates with SF1 and U2AF65 and modulates alternative pre-mRNA splicing in vivo.

PRPF40B SF1

2.16e-06330225605964
Pubmed

Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators.

NCOA3 EP300

2.16e-06330211823864
Pubmed

Mutations of PTCH1, MLL2, and MLL3 are not frequent events in hepatoblastoma.

KMT2C KMT2D

2.16e-06330222183980
Pubmed

AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor.

NCOA3 EP300

2.16e-06330210866661
Pubmed

The transcriptional co-activator p/CIP (NCoA-3) is up-regulated by STAT6 and serves as a positive regulator of transcriptional activation by STAT6.

NCOA3 EP300

2.16e-06330215145939
Pubmed

Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3.

DVL2 DVL3

2.16e-06330218093802
Pubmed

Genomic organization of mouse Dishevelled genes.

DVL2 DVL3

2.16e-0633028973355
Pubmed

Dishevelled family proteins are expressed in non-small cell lung cancer and function differentially on tumor progression.

DVL2 DVL3

2.16e-06330218692936
Pubmed

DVL mutations identified from human neural tube defects and Dandy-Walker malformation obstruct the Wnt signaling pathway.

DVL2 DVL3

2.16e-06330232900645
Pubmed

Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay.

DVL2 DVL3

2.16e-06330227744318
Pubmed

Dishevelled proteins are significantly upregulated in chronic lymphocytic leukaemia.

DVL2 DVL3

2.16e-06330227086035
Pubmed

The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression.

KMT2D EP300

2.16e-06330237410700
Pubmed

Activation of the non-canonical Dvl-Rac1-JNK pathway by Frizzled homologue 10 in human synovial sarcoma.

DVL2 DVL3

2.16e-06330219137009
Pubmed

A WW domain binding region in methyl-CpG-binding protein MeCP2: impact on Rett syndrome.

PRPF40B PRPF40A

2.16e-06330214618241
Pubmed

Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.

KMT2C KMT2D

2.16e-06330223932714
Pubmed

The MN1 oncoprotein synergizes with coactivators RAC3 and p300 in RAR-RXR-mediated transcription.

NCOA3 EP300

2.16e-06330212569362
Pubmed

A UTX-MLL4-p300 Transcriptional Regulatory Network Coordinately Shapes Active Enhancer Landscapes for Eliciting Transcription.

KMT2D EP300

2.16e-06330228732206
Pubmed

HOXC6 Is transcriptionally regulated via coordination of MLL histone methylase and estrogen receptor in an estrogen environment.

KMT2C KMT2D

2.16e-06330221683083
Pubmed

Dishevelled proteins are associated with olfactory sensory neuron presynaptic terminals.

DVL2 DVL3

2.16e-06330223437169
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

NCOA3 KMT2C CHD6 KMT2D PRRC2C RTL9

2.63e-0646930627634302
Pubmed

SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.

PRPF40A PRRC2A PRRC2C SF1 MBNL1

2.65e-0625830537794589
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

NCOA3 SYNRG RBM25 KMT2D PRPF40A PRRC2A SF1

3.43e-0677430715302935
Pubmed

Crucial roles for interactions between MLL3/4 and INI1 in nuclear receptor transactivation.

KMT2C KMT2D

4.31e-06430219221051
Pubmed

Cancer gene mutation frequencies for the U.S. population.

KMT2C KMT2D

4.31e-06430234645806
Pubmed

Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the Wnt signaling pathway.

DVL2 DVL3

4.31e-06430224643799
Pubmed

CBP/p300 interact with and function as transcriptional coactivators of BRCA1.

NCOA3 EP300

4.31e-06430210655477
Pubmed

DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling.

DVL2 DVL3

4.31e-06430225557784
Pubmed

Peptidyl-prolyl isomerase 1 (Pin1) serves as a coactivator of steroid receptor by regulating the activity of phosphorylated steroid receptor coactivator 3 (SRC-3/AIB1).

NCOA3 EP300

4.31e-06430216227615
Pubmed

cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene.

DVL2 DVL3

4.31e-0643028817329
Pubmed

Targeting NSD2-mediated SRC-3 liquid-liquid phase separation sensitizes bortezomib treatment in multiple myeloma.

NCOA3 EP300

4.31e-06430233589584
Pubmed

Human dishevelled genes constitute a DHR-containing multigene family.

DVL2 DVL3

4.31e-0643029192851
Pubmed

Structural Insights of Transcriptionally Active, Full-Length Androgen Receptor Coactivator Complexes.

NCOA3 EP300

4.31e-06430232668201
Pubmed

Activation of p53 by Dishevelled independent of Wnt or planar polarity pathways.

DVL2 DVL3

4.31e-06430217593335
Pubmed

The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers.

KMT2C KMT2D

4.31e-06430224081332
Pubmed

Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways.

DVL2 DVL3

4.31e-06430219625296
Pubmed

A transcriptional switch mediated by cofactor methylation.

NCOA3 EP300

4.31e-06430211701890
Pubmed

Loss of Dishevelleds disrupts planar polarity in ependymal motile cilia and results in hydrocephalus.

DVL2 DVL3

4.31e-06430225043421
Pubmed

A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.

KMT2C KMT2D

4.31e-06430223129768
Pubmed

Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein.

DVL2 DVL3

4.31e-06430219465938
Pubmed

Phosphorylation of Dishevelled by protein kinase RIPK4 regulates Wnt signaling.

DVL2 DVL3

4.31e-06430223371553
Pubmed

Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation.

DVL2 DVL3

4.31e-06430218772438
Pubmed

KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.

RBM25 RBM33 PRPF40A SF1

4.74e-0613030435545047
Pubmed

WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif.

SNRPC PRPF40A

7.18e-0653029724750
Pubmed

Structure of a biologically active estrogen receptor-coactivator complex on DNA.

NCOA3 EP300

7.18e-06530225728767
Pubmed

Helicobacter pylori-induced activation of beta-catenin involves low density lipoprotein receptor-related protein 6 and Dishevelled.

DVL2 DVL3

7.18e-06530220137080
Pubmed

Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family.

DVL2 DVL3

7.18e-06530215456783
Pubmed

A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4.

DVL2 DVL3

7.18e-06530225424568
Pubmed

CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation.

DVL2 DVL3

7.18e-06530224469800
Pubmed

The E3 ubiquitin ligase ITCH negatively regulates canonical Wnt signaling by targeting dishevelled protein.

DVL2 DVL3

7.18e-06530222826439
Pubmed

MLL3/MLL4-Associated PAGR1 Regulates Adipogenesis by Controlling Induction of C/EBPβ and C/EBPδ.

KMT2C KMT2D

7.18e-06530232601106
Pubmed

SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4.

NCOA3 EP300

7.18e-0653029812974
Pubmed

Ligand-independent interactions of p160/steroid receptor coactivators and CREB-binding protein (CBP) with estrogen receptor-alpha: regulation by phosphorylation sites in the A/B region depends on other receptor domains.

NCOA3 EP300

7.18e-06530212714702
Pubmed

Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF.

KMT2C KMT2D

7.18e-06530231127101
Pubmed

Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein.

RARG EP300

7.18e-06530210336495
Pubmed

Fbxo22-mediated KDM4B degradation determines selective estrogen receptor modulator activity in breast cancer.

NCOA3 EP300

7.18e-06530230418174
Pubmed

A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex.

KMT2C KMT2D

7.18e-06530226744420
Pubmed

Tagging genes with cassette-exchange sites.

NCOA3 KMT2C RARG PRPF40A PRRC2C

9.41e-0633530515741177
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

KMT2C CHD6 RBM25 KMT2D SNRPC PRPF40A SF1 EP300

1.01e-05129430830804502
Pubmed

High expression of IGFBP7 in fibroblasts induced by colorectal cancer cells is co-regulated by TGF-β and Wnt signaling in a Smad2/3-Dvl2/3-dependent manner.

DVL2 DVL3

1.08e-05630224427302
Pubmed

Temporal/spatial expression of nuclear receptor coactivators in the mouse lung.

NCOA3 EP300

1.08e-05630211076796
Pubmed

Deletion of the Dishevelled family of genes disrupts anterior-posterior axis specification and selectively prevents mesoderm differentiation.

DVL2 DVL3

1.08e-05630232579954
Pubmed

Targeting E3 Ubiquitin Ligase WWP1 Prevents Cardiac Hypertrophy Through Destabilizing DVL2 via Inhibition of K27-Linked Ubiquitination.

DVL2 DVL3

1.08e-05630234139860
Pubmed

Nuclear factor of activated T cells (NFAT) proteins repress canonical Wnt signaling via its interaction with Dishevelled (Dvl) protein and participate in regulating neural progenitor cell proliferation and differentiation.

DVL2 DVL3

1.08e-05630221880741
Pubmed

Structural and Functional Impacts of ER Coactivator Sequential Recruitment.

NCOA3 EP300

1.08e-05630228844863
Pubmed

Roles of coactivators in hypoxic induction of the erythropoietin gene.

NCOA3 EP300

1.08e-05630220368990
Pubmed

SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling.

DVL2 DVL3

1.08e-05630220439735
Pubmed

Signaling within a coactivator complex: methylation of SRC-3/AIB1 is a molecular switch for complex disassembly.

NCOA3 EP300

1.08e-05630216923966
Pubmed

Activation of rapid oestrogen signalling in aggressive human breast cancers.

NCOA3 EP300

1.08e-05630223065768
Pubmed

Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases.

KMT2C KMT2D

1.08e-05630217021013
Pubmed

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.

DVL2 IST1 CHD6 SSPOP PRPF40A PRRC2A

1.16e-0560830616713569
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

DVL2 DVL3 CHD6 RBM25 SNRPC PRPF40A SF1 MBNL1

1.16e-05131830830463901
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

DVL2 IST1 SYNRG PRPF40A PRRC2A PRRC2C SF1

1.17e-0593430733916271
Pubmed

Interaction network of human early embryonic transcription factors.

NCOA3 KMT2C KMT2D SOBP EP300

1.18e-0535130538297188
InteractionALG13 interactions

NCOA3 RBM25 KMT2D SMAP2 RBM33 PRPF40A PRRC2A PRRC2C SF1 EP300

7.64e-141833010int:ALG13
InteractionNUP35 interactions

NCOA3 KMT2C KMT2D PRPF40B SNRPC RBM33 PRPF40A PRRC2C EP300 MBNL1

3.15e-104243010int:NUP35
InteractionWWTR1 interactions

DVL2 DVL3 SYNRG RBM25 KMT2D PRPF40A PRRC2A PRRC2C EP300

6.89e-09422309int:WWTR1
InteractionSP7 interactions

NCOA3 KMT2C RBM25 KMT2D RBM33 PRPF40A EP300 MBNL1

1.07e-08304308int:SP7
InteractionEYA4 interactions

DVL3 NCOA3 SNRPC RBM33 SOBP SF1 EP300

5.46e-08243307int:EYA4
InteractionDAZL interactions

SMAP2 RBM33 PRRC2A PRRC2C SF1 MBNL1

6.44e-08145306int:DAZL
InteractionELF5 interactions

KMT2C RBM25 KMT2D SNRPC PRPF40A EP300

6.99e-08147306int:ELF5
InteractionKLF4 interactions

DVL3 NCOA3 KMT2C KMT2D MYO15B EP300

1.16e-07160306int:KLF4
InteractionKLF15 interactions

DVL3 NCOA3 KMT2C KMT2D PRRC2A PRRC2C EP300

1.82e-07290307int:KLF15
InteractionSNRPA interactions

RBM25 SNRPC PRPF40A PRRC2C SF1 EP300 MBNL1 ENOX2

3.72e-07482308int:SNRPA
InteractionPAX7 interactions

NCOA3 KMT2C CHD6 KMT2D EP300

1.02e-06124305int:PAX7
InteractionTLE3 interactions

NCOA3 CHD6 KMT2D PRPF40B SNRPC EP300 MBNL1

1.05e-06376307int:TLE3
InteractionPAX9 interactions

NCOA3 KMT2C KMT2D EP300 MBNL1

1.29e-06130305int:PAX9
InteractionCRX interactions

NCOA3 KMT2C KMT2D MYO15B SMAP2 EP300

1.74e-06254306int:CRX
InteractionFAM168A interactions

DVL2 SNRPC SMAP2 SF1 MEIS2

2.00e-06142305int:FAM168A
InteractionNCOA1 interactions

NCOA3 RARG SNRPC SF1 EP300

2.29e-06146305int:NCOA1
InteractionGCM1 interactions

NCOA3 KMT2C KMT2D EP300

3.04e-0668304int:GCM1
InteractionSOX6 interactions

NCOA3 RBM33 SOBP PRRC2A PRRC2C

3.28e-06157305int:SOX6
InteractionRPA4 interactions

DVL2 DVL3 RBM25 PRPF40A PRRC2A PRRC2C SF1

3.55e-06452307int:RPA4
InteractionCELF1 interactions

SMAP2 RBM33 PRRC2A PRRC2C SF1 MBNL1

3.60e-06288306int:CELF1
InteractionPRPF3 interactions

DVL2 DVL3 RBM25 SNRPC PRPF40A EP300

3.82e-06291306int:PRPF3
InteractionSOX5 interactions

CHD6 KMT2D RBM33 PRRC2A PRRC2C

3.82e-06162305int:SOX5
InteractionFUBP3 interactions

SMAP2 RBM33 PRRC2A PRRC2C SF1 EP300

4.29e-06297306int:FUBP3
InteractionTLX1 interactions

NCOA3 KMT2C KMT2D EP300 MEIS2

5.57e-06175305int:TLX1
InteractionHNF1A interactions

NCOA3 KMT2C KMT2D EP300

5.83e-0680304int:HNF1A
InteractionZBTB8A interactions

DVL2 DVL3 MYO15B EP300

6.13e-0681304int:ZBTB8A
InteractionSOX7 interactions

NCOA3 KMT2C KMT2D EP300

6.44e-0682304int:SOX7
InteractionDDX6 interactions

DVL2 RBM25 SMAP2 PRPF40A PRRC2A PRRC2C EP300

7.16e-06503307int:DDX6
InteractionIRF4 interactions

NCOA3 KMT2C KMT2D EP300

7.43e-0685304int:IRF4
InteractionGSC interactions

NCOA3 KMT2C KMT2D EP300

8.15e-0687304int:GSC
InteractionCPSF7 interactions

DVL2 RBM25 SNRPC PRPF40A SF1 EP300

9.00e-06338306int:CPSF7
InteractionKLF5 interactions

NCOA3 KMT2C KMT2D PRRC2A EP300

9.43e-06195305int:KLF5
InteractionSNW1 interactions

DVL2 DVL3 MYO15B SNRPC RBM33 PRPF40A SF1 EP300

9.73e-06747308int:SNW1
InteractionSMC5 interactions

RBM25 SNAP91 SNRPC RBM33 PRPF40A PRRC2A PRRC2C SF1 MBNL1

9.78e-061000309int:SMC5
InteractionFOXI1 interactions

NCOA3 KMT2C KMT2D EP300

1.02e-0592304int:FOXI1
InteractionGATA2 interactions

NCOA3 KMT2C CHD6 KMT2D EP300

1.04e-05199305int:GATA2
InteractionBEND7 interactions

DVL2 DVL3 MYO15B PRPF40A

1.11e-0594304int:BEND7
InteractionFEV interactions

NCOA3 KMT2C CHD6 KMT2D EP300

1.15e-05203305int:FEV
InteractionNEIL3 interactions

RBM25 PRPF40A PRRC2A SF1

1.26e-0597304int:NEIL3
InteractionSOX9 interactions

NCOA3 KMT2C KMT2D EP300

1.26e-0597304int:SOX9
InteractionRBM39 interactions

DVL3 RBM25 SNRPC PRPF40A PRRC2A PRRC2C SF1 EP300 MBNL1

1.36e-051042309int:RBM39
InteractionPAX6 interactions

NCOA3 KMT2C CHD6 KMT2D EP300 MEIS2

1.41e-05366306int:PAX6
InteractionERG interactions

NCOA3 KMT2C KMT2D PRPF40A EP300

1.80e-05223305int:ERG
InteractionFOXK2 interactions

DVL2 DVL3 KMT2D PRRC2C EP300

1.88e-05225305int:FOXK2
InteractionKLF3 interactions

DVL3 CHD6 KMT2D SOBP EP300

2.01e-05228305int:KLF3
InteractionPAX8 interactions

NCOA3 KMT2C KMT2D EP300

2.14e-05111304int:PAX8
InteractionKLF1 interactions

DVL3 SNRPC EP300

2.24e-0537303int:KLF1
InteractionPSMF1 interactions

DVL2 DVL3 PRRC2A PRRC2C

2.29e-05113304int:PSMF1
InteractionTBR1 interactions

NCOA3 KMT2C KMT2D EP300

2.29e-05113304int:TBR1
InteractionAP1B1 interactions

DVL2 SYNRG SNAP91 SMAP2 EP300

2.42e-05237305int:AP1B1
InteractionTBXT interactions

NCOA3 KMT2C KMT2D EP300

2.54e-05116304int:TBXT
InteractionLUC7L interactions

RBM25 SNRPC PRPF40A PRRC2A EP300

2.67e-05242305int:LUC7L
InteractionBAG2 interactions

RBM25 SMAP2 RBM33 PRRC2C SF1 EP300 MBNL1

2.83e-05622307int:BAG2
InteractionCHEK2 interactions

DVL2 RBM25 KMT2D SNRPC PRPF40A

3.12e-05250305int:CHEK2
InteractionRNPS1 interactions

DVL2 RBM25 SNRPC RBM33 PRPF40A EP300

3.28e-05425306int:RNPS1
InteractionNPAS2 interactions

NCOA3 RBM25 EP300

3.29e-0542303int:NPAS2
InteractionCPSF1 interactions

RBM25 SNRPC PRPF40A PRRC2A EP300

3.43e-05255305int:CPSF1
InteractionSNRPB2 interactions

RBM25 SNRPC PRPF40A SF1 EP300

3.43e-05255305int:SNRPB2
InteractionRARB interactions

NCOA3 RARG EP300

4.33e-0546303int:RARB
InteractionSORCS3 interactions

RBM33 SF1

4.48e-057302int:SORCS3
InteractionCWC15 interactions

RBM25 SNRPC PRPF40A SF1

4.48e-05134304int:CWC15
InteractionBCAS2 interactions

RBM25 SNRPC SF1 EP300 MBNL1

4.51e-05270305int:BCAS2
InteractionSRRM2 interactions

RBM25 PRPF40B SNRPC PRPF40A PRRC2C EP300

5.23e-05462306int:SRRM2
InteractionSOX15 interactions

NCOA3 KMT2D EP300 MBNL1

5.46e-05141304int:SOX15
InteractionCEBPA interactions

NCOA3 KMT2C KMT2D RBM33 PRRC2A PRRC2C SF1 EP300 MBNL1

5.57e-051245309int:CEBPA
InteractionMAB21L2 interactions

IST1 PRPF40A PRRC2C MEIS2

5.77e-05143304int:MAB21L2
InteractionNCOA6 interactions

KMT2C KMT2D SF1 EP300

6.09e-05145304int:NCOA6
InteractionTLX3 interactions

NCOA3 KMT2C CHD6 KMT2D EP300

6.43e-05291305int:TLX3
InteractionMAP2K1 interactions

DVL2 RBM25 RBM33 SF1 EP300

6.64e-05293305int:MAP2K1
InteractionMFAP1 interactions

RBM25 PRPF40B SNRPC PRPF40A EP300

6.86e-05295305int:MFAP1
InteractionAP1G1 interactions

DVL2 SYNRG SMAP2 EP300

6.95e-05150304int:AP1G1
InteractionIFI6 interactions

RBM25 PRPF40A PRRC2A

7.01e-0554303int:IFI6
InteractionSNRPA1 interactions

RBM25 SNRPC PRPF40A SF1 EP300

7.42e-05300305int:SNRPA1
InteractionSAP18 interactions

NCOA3 RBM25 SNRPC RBM33 PRPF40A

8.03e-05305305int:SAP18
InteractionNCBP3 interactions

SNRPC RBM33 PRPF40A EP300

8.09e-05156304int:NCBP3
InteractionRARG interactions

NCOA3 RARG EP300

8.69e-0558303int:RARG
InteractionPRPF38A interactions

DVL3 RBM25 SNRPC PRPF40A

9.15e-05161304int:PRPF38A
InteractionSSBP4 interactions

MYO15B EP300 MBNL1

9.15e-0559303int:SSBP4
InteractionEEA1 interactions

DVL2 DVL3 RBM33 EP300

9.37e-05162304int:EEA1
InteractionFSAF1 interactions

SNRPC RBM33 PRPF40A

9.62e-0560303int:FSAF1
InteractionSMG7 interactions

NCOA3 KMT2D SMAP2 RBM33 PRRC2A

9.91e-05319305int:SMG7
InteractionETS2 interactions

DVL2 NCOA3 EP300

1.01e-0461303int:ETS2
InteractionRBM25 interactions

RBM25 PRPF40B SNRPC PRPF40A EP300

1.05e-04323305int:RBM25
InteractionFOXA1 interactions

IST1 NCOA3 KMT2C RBM25 ONECUT1 SF1

1.06e-04525306int:FOXA1
InteractionRBM11 interactions

CHD6 MYO15B SNRPC PRRC2A

1.10e-04169304int:RBM11
InteractionKLF8 interactions

NCOA3 KMT2D PRRC2A PRRC2C EP300

1.15e-04329305int:KLF8
InteractionPRP4K interactions

RBM25 SNRPC PRPF40A PRRC2A EP300

1.15e-04329305int:PRP4K
InteractionEGR2 interactions

NCOA3 KMT2C KMT2D EP300

1.15e-04171304int:EGR2
InteractionIFI27L1 interactions

RBM25 PRPF40A PRRC2A

1.22e-0465303int:IFI27L1
InteractionRBPMS interactions

DVL2 SNRPC SF1 MEIS2 MBNL1

1.34e-04340305int:RBPMS
InteractionETV4 interactions

NCOA3 KMT2D EP300

1.46e-0469303int:ETV4
InteractionGATA3 interactions

NCOA3 KMT2D PRPF40A EP300

1.63e-04187304int:GATA3
InteractionATN1 interactions

DVL2 KMT2C SSPOP PRRC2A

1.63e-04187304int:ATN1
InteractionASCL2 interactions

KMT2C EP300

1.65e-0413302int:ASCL2
InteractionNFIA interactions

NCOA3 RBM25 KMT2D EP300

1.66e-04188304int:NFIA
InteractionSMAP2 interactions

SYNRG SMAP2 PRRC2A PRRC2C

1.70e-04189304int:SMAP2
InteractionPAXIP1 interactions

KMT2C RBM25 KMT2D PRPF40A EP300

1.72e-04359305int:PAXIP1
InteractionHNF1B interactions

NCOA3 KMT2C KMT2D EP300

1.73e-04190304int:HNF1B
InteractionCEBPB interactions

RBM25 KMT2D SNRPC PRPF40A PRRC2A PRRC2C SF1 EP300 MBNL1

1.74e-041443309int:CEBPB
InteractionMYOD1 interactions

NCOA3 KMT2C KMT2D EP300

1.88e-04194304int:MYOD1
Cytoband20q12

NCOA3 CHD6

1.13e-042430220q12
CytobandEnsembl 112 genes in cytogenetic band chr7q36

KMT2C RBM33 SSPOP

1.55e-04159303chr7q36
Cytoband7q36.1

KMT2C SSPOP

1.08e-03743027q36.1
CytobandEnsembl 112 genes in cytogenetic band chr12q13

KMT2D RARG PRPF40B

2.62e-03423303chr12q13
GeneFamilyDishevelled segment polarity proteins|PDZ domain containing

DVL2 DVL3

6.27e-064192505
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

NCOA3 EP300

1.41e-0417192486
GeneFamilyAtaxins|Trinucleotide repeat containing

NCOA3 KMT2D

3.09e-0425192775
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

KMT2C KMT2D

5.75e-0434192487
GeneFamilyRNA binding motif containing

RBM25 RBM33 ENOX2

1.36e-03213193725
GeneFamilyPHD finger proteins

KMT2C KMT2D

3.97e-039019288
GeneFamilyPDZ domain containing

DVL2 DVL3

1.09e-021521921220
CoexpressionBUSSLINGER_GASTRIC_IMMUNE_CELLS

NCOA3 SYNRG KMT2C KMT2D SMAP2 RBM33 PRPF40A SF1 EP300 MBNL1

3.64e-0614923010M40023
CoexpressionGSE15624_CTRL_VS_3H_HALOFUGINONE_TREATED_CD4_TCELL_UP

DVL3 NCOA3 RARG PRPF40B

3.24e-05160304M7116
CoexpressionGSE24671_CTRL_VS_SENDAI_VIRUS_INFECTED_MOUSE_SPLENOCYTES_DN

KMT2C RBM25 KMT2D PRRC2C

7.57e-05199304M9443
CoexpressionGSE411_WT_VS_SOCS3_KO_MACROPHAGE_DN

DVL2 CHD6 RBM33 SF1

7.72e-05200304M5991
CoexpressionAtlasDevelopingGonad_e11.5_testes_emap-3226_top-relative-expression-ranked_1000

DVL2 RBM25 SNRPC PRPF40A PRRC2A PRRC2C SF1 MEIS2

1.60e-05843308gudmap_developingGonad_e11.5_testes_1000
CoexpressionAtlaskidney_P0_CapMes_Crym_k-means-cluster#3_top-relative-expression-ranked_200

SNAP91 SOBP MEIS2

1.91e-0537303gudmap_kidney_P0_CapMes_Crym_k3_200
CoexpressionAtlaskidney_P1_CapMes_Crym_k-means-cluster#4_top-relative-expression-ranked_200

SNAP91 SOBP MEIS2

5.68e-0553303gudmap_kidney_P1_CapMes_Crym_k4_200
CoexpressionAtlasDevelopingGonad_e11.5_testes_emap-3226_k-means-cluster#2_top-relative-expression-ranked_1000

DVL2 RBM25 PRPF40A PRRC2A

1.63e-04197304gudmap_developingGonad_e11.5_testes_k2_1000
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

KMT2C RBM25 RBM33 PRRC2C SF1 MBNL1

3.89e-0920030612f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellCOVID-19|World / Disease, condition lineage and cell class

KMT2C RBM25 SMAP2 PRRC2C SF1 MBNL1

3.89e-092003067dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCellsevere-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

KMT2C RBM25 PRRC2C SF1 MBNL1

1.99e-0719730557ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell3'_v3-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

RBM25 KMT2D SF1 MBNL1

2.81e-0614730494998bc40f5c08295cfe3bdcbe43f13b1e564b3d
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-B_cell-B_cell|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NCOA3 SMAP2 EP300 MBNL1

6.12e-06179304fad1fbee002fcd424c03460d695559060ce41a3f
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-B_cell|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NCOA3 SMAP2 EP300 MBNL1

6.12e-061793046d4e4b64e633b2ae8514ffa1e45829d6508dac54
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-B_cell-B_cell-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NCOA3 SMAP2 EP300 MBNL1

6.12e-0617930461a7cc01fae4115325fce0efaa5bacf8f9af5ba2
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

KMT2C RBM25 SF1 MBNL1

8.08e-0619230447646d7e4990be85072987f92bf18d52f8da752e
ToppCellhuman_hepatoblastoma|World / Sample and Cell Type and Tumor Cluster (all cells)

CHD6 RBM33 PRRC2C MBNL1

8.24e-06193304e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCellH1299-infected-SARSCoV2|infected / Cell line, Condition and Strain

RBM25 PRPF40A PRRC2A PRRC2C

8.94e-061973040fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCellCOVID-19_Mild|World / Disease group, lineage and cell class

KMT2C RBM25 PRRC2C SF1

8.94e-061973045c33454b10023decd2f5ccda9229b6512659711e
ToppCellmoderate-Lymphoid-CTL|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

SYNRG PRRC2C SF1 MBNL1

9.12e-061983040a868098b1ee4b28b2149ed766acb09e9c0ce14c
ToppCellPBMC_fresh-frozen|World / Compartment, severity and other cell annotations on 10x 3' data (130k)

RBM25 PRRC2C SF1 MBNL1

9.12e-06198304dcc223a0396b8b673e4ed8c6733ec6cd74e9a03a
ToppCellPBMC-Mild|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)

KMT2C RBM25 PRRC2C SF1

9.12e-0619830444417089b62056269cac38d3134ff209c05b7007
ToppCellPBMC-Mild|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

KMT2C RBM25 PRRC2C SF1

9.12e-0619830428ef3fc4c17dcb765537b75917f7db78baa522db
ToppCellmegakaryocytic-CD34+_Megakaryoblast|megakaryocytic / Lineage and Cell class

RBM25 PRPF40A PRRC2C SF1

9.30e-0619930499a65887d3c8a2cde26693dd74404b101bba9d58
ToppCell10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8|bone_marrow / Manually curated celltypes from each tissue

KMT2C RBM25 SF1

1.55e-041563031545169694f686d28648a68b552c2ae606599d66
ToppCellnormal_Lymph_Node-B_lymphocytes-Undetermined|normal_Lymph_Node / Location, Cell class and cell subclass

SMAP2 PRRC2C SF1

1.73e-0416230391ac35ae7fde411cd6a44e715a33dac62419cab8
ToppCell5'-Adult-SmallIntestine-Epithelial-Tuft-related-Tuft|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KMT2C CHD6 RTL9

1.93e-041683038072d0496b7b730c4601009eaa69ec5366d26d73
ToppCellC_00|World / shred on cell type and cluster

CHD6 RBM25 PRRC2C

2.32e-04179303da2dadc3266ffebd4a34ac61bfa05fddcadcde4c
ToppCelldroplet-Liver-LIVER_HEP|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RARG PRRC2C MEIS2

2.36e-04180303423454e3390080ae03bb3cbb267255ebfe4df080
ToppCelldroplet-Liver-LIVER_HEP-30m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RARG PRRC2C MEIS2

2.36e-04180303dd1b10c7f5a0fbc63163844ca1882884a24a84d3
ToppCelldroplet-Marrow-nan-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRRC2C EP300 MBNL1

2.52e-041843031154a5ad7b8512272b7476f949ddac350910bfb7
ToppCellBrain_organoid-organoid_Kanton_Nature|Brain_organoid / Sample Type, Dataset, Time_group, and Cell type.

CHD6 RBM25 PRRC2C

2.56e-04185303857c7ca8493e91ef1d0078ddafd6082020f9b169
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

KMT2C RBM25 PRRC2C

2.60e-0418630323b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCelldroplet-Bladder-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RBM25 PRPF40A PRRC2C

2.64e-04187303663991a8afe652e92363b64bcbd68c14d0307f0e
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

KMT2C RBM25 MBNL1

2.68e-04188303ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCelldroplet-Tongue-nan|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RBM25 PRPF40A PRRC2C

2.68e-04188303d62cc37e86b7b186e53aeb7f421c4e5ee28f23bd
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)

RBM25 SF1 MBNL1

2.72e-041893030e8d1be3c406d1a393e18faccfe89116a8f82bcf
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)

IST1 PRRC2C SF1

2.81e-041913031ecd9849d14d5ebf3daf610e83fb50820cafd3ed
ToppCellfacs-Thymus-nan-3m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KMT2C PRRC2C SF1

2.94e-0419430366c056232ac216780acf4cc8ea325bd8ed1909c9
ToppCellfacs-Thymus-nan-3m|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KMT2C PRRC2C SF1

2.94e-04194303f1661f9f2439fca5c1012c693b0744c4e3b90a9b
ToppCellfacs-Thymus-nan|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KMT2C PRRC2C SF1

2.94e-04194303cda1b197efb199330ea7ab25a7cee22cae22589d
ToppCellCV-Severe-6|CV / Virus stimulation, Condition and Cluster

IST1 NCOA3 RARG

2.99e-0419530369095c6ce2a7e763afa543c10d5710e0c3dda769
ToppCellCOVID-19_Severe|World / Disease condition and Cell class

SMAP2 PRRC2C MBNL1

3.03e-04196303450ac2aff89c5ca73b8bfbc80663e03be066931f
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IST1 PRRC2C MBNL1

3.03e-04196303151f1a29a91f8b234e9b6ed062666357a2f69128
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCOA3 RARG MEIS2

3.03e-0419630381900dcc9451ff6606ec940c16b559d73247590e
ToppCellControl-Classical_Monocyte-cMono_2|Classical_Monocyte / Disease condition and Cell class

SMAP2 PRRC2C MBNL1

3.08e-04197303eb7610c9496a95a5fd866e16abcbc39b83abe617
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

SMAP2 PRRC2C SF1

3.08e-04197303ef2d1f56acd0be43e69bba7f73f6909ba87f1cb3
ToppCellCOVID-19_Mild|World / Disease condition and Cell class

KMT2C RBM25 PRRC2C

3.12e-0419830361ceb2245b6cb58e308b999a61d218c89dbc615e
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

SMAP2 PRRC2C SF1

3.12e-041983038a7897d98f5296745d9005a7cd777f0a2f78000d
ToppCell(05)_Secretory-(2)_GFP_FOXI1|(05)_Secretory / shred by cell type by condition

RBM25 PRPF40A PRRC2C

3.17e-04199303d72d87e1e530ed894c0ad5e7b5b2b1d6b59fa098
ToppCell(04)_Interm._basal>secr.-(2)_GFP_FOXI1|(04)_Interm._basal>secr. / shred by cell type by condition

RBM25 PRPF40A PRRC2C

3.17e-0419930353ca3861f9e00dab3f3fbefb0837857ee39ab084
ToppCell(00)_Basal-(2)_GFP_FOXI1|(00)_Basal / shred by cell type by condition

SOBP PRPF40A PRRC2C

3.17e-0419930319674e1eaeb51e4196d847cb62aa437c852951d3
ToppCell(01)_IL1RL1+-(2)_GFP_FOXI1|(01)_IL1RL1+ / shred by cell type by condition

RBM25 SOBP PRRC2C

3.17e-04199303a2f7d0cabf35b80fe239fae34a77bf9344d5d743
ToppCellCOVID-19-COVID-19_Mild|COVID-19 / Disease, condition lineage and cell class

RBM25 PRRC2C SF1

3.22e-0420030362c25042086f1afd1102e0720e933c2e476468fd
ToppCellVE|World / Condition, Cell_class and T cell subcluster

SMAP2 PRRC2C MBNL1

3.22e-042003038ae7cb81de3ffac5acdf3466d4b516d80cac95d3
ToppCellSigmoid-Dendritic_cell-cDC2|Dendritic_cell / Region, Cell class and subclass

SYNRG SMAP2

4.18e-04453025488dced1d338166f3021509ebe8673e03995978
ComputationalNeighborhood of RTN1

SNAP91 SOBP NCAN

1.15e-0452203GNF2_RTN1
DrugCaptopril [62571-86-2]; Down 200; 17.2uM; PC3; HT_HG-U133A

NCOA3 RBM25 PRPF40A PRRC2C MBNL1

3.45e-061793054585_DN
DrugNeostigmine bromide [114-80-7]; Down 200; 13.2uM; PC3; HT_HG-U133A

NCOA3 RBM25 PRPF40A PRRC2C SF1

4.39e-061883056735_DN
Drugnocodazole; Up 200; 1uM; MCF7; HG-U133A

SYNRG RARG PRRC2A SF1 ENOX2

5.24e-06195305621_UP
DiseaseBladder Neoplasm

KMT2C CHD6 KMT2D EP300 NCAN

2.90e-07140305C0005695
DiseaseMalignant neoplasm of urinary bladder

KMT2C CHD6 KMT2D EP300 NCAN

3.00e-07141305C0005684
DiseaseKleefstra syndrome 2 (implicated_via_orthology)

KMT2C KMT2D

9.99e-072302DOID:0080598 (implicated_via_orthology)
DiseaseCarcinoma, Transitional Cell

KMT2C CHD6 EP300

9.85e-0641303C0007138
Diseaseprostate cancer (is_marker_for)

NCOA3 KMT2C KMT2D EP300

1.85e-05156304DOID:10283 (is_marker_for)
Diseasebreast carcinoma (is_marker_for)

NCOA3 KMT2D EP300

4.16e-0566303DOID:3459 (is_marker_for)
Diseasecongenital heart disease (implicated_via_orthology)

KMT2C CHD6 KMT2D

4.75e-0569303DOID:1682 (implicated_via_orthology)
Diseasetaurodeoxycholate measurement

SMAP2 MBNL1

6.55e-0512302EFO_0010539
DiseaseT-Cell Lymphoma

KMT2D EP300

1.19e-0416302C0079772
DiseaseSquamous cell carcinoma of esophagus

KMT2C KMT2D EP300

1.23e-0495303C0279626
DiseaseSezary Syndrome

KMT2C KMT2D

3.45e-0427302C0036920
DiseaseMalignant neoplasm of breast

DVL3 NCOA3 KMT2D RARG PRRC2A EP300

6.43e-041074306C0006142
Diseaseesophagus squamous cell carcinoma (is_implicated_in)

KMT2C KMT2D

9.63e-0445302DOID:3748 (is_implicated_in)
Diseasevital capacity

NCOA3 RARG SNRPC MEIS2 RTL9 MBNL1

1.33e-031236306EFO_0004312
DiseaseDiffuse Large B-Cell Lymphoma

KMT2D EP300

1.44e-0355302C0079744
Diseasecognitive function measurement

RBM25 KMT2D RARG PRPF40B PRRC2C MEIS2

2.83e-031434306EFO_0008354
DiseaseCleft Palate

RARG MEIS2

3.08e-0381302C0008925
DiseaseProstatic Neoplasms

NCOA3 KMT2C CHD6 KMT2D

3.35e-03616304C0033578
DiseaseMalignant neoplasm of prostate

NCOA3 KMT2C CHD6 KMT2D

3.35e-03616304C0376358
DiseaseAdenoid Cystic Carcinoma

KMT2C EP300

4.65e-03100302C0010606
Diseaseschizophrenia, intelligence, self reported educational attainment

RARG SNAP91 PRPF40B

5.13e-03346303EFO_0004337, EFO_0004784, MONDO_0005090
DiseaseAdenocarcinoma

NCOA3 KMT2C

6.20e-03116302C0001418
DiseaseCarcinoma, Granular Cell

NCOA3 KMT2C

6.20e-03116302C0205644
DiseaseAdenocarcinoma, Tubular

NCOA3 KMT2C

6.20e-03116302C0205645
DiseaseAdenocarcinoma, Oxyphilic

NCOA3 KMT2C

6.20e-03116302C0205642
DiseaseCarcinoma, Cribriform

NCOA3 KMT2C

6.20e-03116302C0205643
DiseaseAdenocarcinoma, Basal Cell

NCOA3 KMT2C

6.20e-03116302C0205641
DiseaseSquamous cell carcinoma

NCOA3 EP300

7.06e-03124302C0007137

Protein segments in the cluster

PeptideGeneStartEntry
MPPMTPMAPMGMNPP

EP300

1956

Q09472
PMAPMGMNPPPMTRG

EP300

1961

Q09472
GMPPAGTGMPMMPQQ

SNAP91

841

O60641
MLMMPPPPAAMGPPG

DVL3

666

Q92997
PGMALPYNPMMVVMM

DVL2

671

O14641
GTPMIPVPMSIMAPA

RBM25

36

P49756
MPPQLETPRMMMTPP

RBM33

361

Q96EV2
KMEIPGPMPPLIREM

RARG

401

P13631
LGMPPMVMSRFPFMG

KMT2C

3116

Q8NEZ4
PAMMMHGGPPTHPGM

MEIS2

436

O14770
ALGMMTGIPPITPMM

ENOX2

66

Q16206
TMTMACETPPGMSMP

ONECUT1

86

Q9UBC0
NMPPVPHGMMPQMMP

PRPF40A

76

O75400
AYQPGMVPAPMPMMP

MYO15B

831

Q96JP2
MVPAPMPMMPAMGTV

MYO15B

836

Q96JP2
MPMMPAMGTVPAMPA

MYO15B

841

Q96JP2
AMGTVPAMPAMVVPP

MYO15B

846

Q96JP2
SMLPMMLPGMAAVPQ

CHD6

2516

Q8TD26
MMPGAPLQPVPMFSV

MBNL1

106

Q9NR56
GTVPMPMPMPMPSAN

IST1

226

P53990
APASGTMPMPLMSAM

RTL9

956

Q8NET4
VPFMMPTMALPGLPA

SSPOP

2446

A2VEC9
PPMMRPPARPMMVPT

SNRPC

136

P09234
PPARPMMVPTRPGMT

SNRPC

141

P09234
PIAMQAGIPMGPMPA

SYNRG

76

Q9UMZ2
PMMAMLRGPKEWMLP

NCAN

631

O14594
NMNPMPMSGMPMGPD

NCOA3

1406

Q9Y6Q9
PRMMSGRPAMDIPPI

PRRC2C

746

Q9Y520
PPPMPPMNFDPRWMM

PRRC2A

711

P48634
MAMLIPLMPLMPPPS

SPPL2C

631

Q8IUH8
PNSIMGSMMPPPVGM

SMAP2

306

Q8WU79
MPNGPMPVPQMMNFG

SOBP

496

A7XYQ1
PGMVPPMMPGMLMPA

PRPF40B

56

Q6NWY9
PMMPGMLMPAVPVTA

PRPF40B

61

Q6NWY9
MGMGVAGMPPFGMPP

SF1

616

Q15637
PMGTMPPSMCMKPQQ

KMT2D

3381

O14686