Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	Ion_trans_dom	CACNA1B SCN11A KCNH4 NALCN TRPM3 SCN10A KCNS3 CNGA4	2.56e-06	114	142	8	IPR005821
Domain	Ion_trans	CACNA1B SCN11A KCNH4 NALCN TRPM3 SCN10A KCNS3 CNGA4	2.56e-06	114	142	8	PF00520
Domain	Channel_four-helix_dom	CACNA1B SCN11A NALCN SCN10A KCNS3	7.21e-05	57	142	5	IPR027359
Domain	-	CACNA1B SCN11A NALCN SCN10A KCNS3	7.21e-05	57	142	5	1.20.120.350
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	FLT1 POLRMT NBEA MAGT1 USP9Y TRRAP TTC19 VPS13D CYFIP1 TRANK1 DNAH12 ZNF592 ANO3	2.35e-07	497	148	13	36774506
Pubmed	Heat-resistant action potentials require TTX-resistant sodium channels NaV1.8 and NaV1.9.	SCN11A SCN10A	1.80e-05	2	148	2	29970412
Pubmed	Correlation of Nav1.8 and Nav1.9 sodium channel expression with neuropathic pain in human subjects with lingual nerve neuromas.	SCN11A SCN10A	1.80e-05	2	148	2	24144460
Pubmed	Sodium Channel Nav1.8 Underlies TTX-Resistant Axonal Action Potential Conduction in Somatosensory C-Fibers of Distal Cutaneous Nerves.	SCN11A SCN10A	1.80e-05	2	148	2	28450535
Pubmed	Maladaptive activation of Nav1.9 channels by nitric oxide causes triptan-induced medication overuse headache.	SCN11A SCN10A	1.80e-05	2	148	2	31534133
Pubmed	Localization and subcellular distribution of prolyl oligopeptidase in the mouse placenta.	FLT1 PREP	1.80e-05	2	148	2	21544597
Pubmed	Tetrodotoxin-resistant voltage-gated sodium channels Na(v)1.8 and Na(v)1.9 are expressed in the retina.	SCN11A SCN10A	1.80e-05	2	148	2	18399542
Pubmed	CKLF1 Aggravates Focal Cerebral Ischemia Injury at Early Stage Partly by Modulating Microglia/Macrophage Toward M1 Polarization Through CCR4.	CMTM2 CCR4	1.80e-05	2	148	2	30982091
Pubmed	Human Dicer C-terminus functions as a 5-lipoxygenase binding domain.	DICER1 ALOX5	1.80e-05	2	148	2	19022417
Pubmed	Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets.	RAP1GAP2 SYTL1	1.80e-05	2	148	2	19528539
Pubmed	Small RNAs control sodium channel expression, nociceptor excitability, and pain thresholds.	DICER1 SCN10A	1.80e-05	2	148	2	20702715
Pubmed	Exploring the role of nociceptor-specific sodium channels in pain transmission using Nav1.8 and Nav1.9 knockout mice.	SCN11A SCN10A	1.80e-05	2	148	2	19931571
Pubmed	Contributions of NaV1.8 and NaV1.9 to excitability in human induced pluripotent stem-cell derived somatosensory neurons.	SCN11A SCN10A	1.80e-05	2	148	2	34930944
Pubmed	Dissecting the role of sodium currents in visceral sensory neurons in a model of chronic hyperexcitability using Nav1.8 and Nav1.9 null mice.	SCN11A SCN10A	1.80e-05	2	148	2	16857712
Pubmed	The Nav1.9 channel is a key determinant of cold pain sensation and cold allodynia.	SCN11A SCN10A	1.80e-05	2	148	2	25959819
Pubmed	A disease mutation reveals a role for NaV1.9 in acute itch.	SCN11A SCN10A	5.38e-05	3	148	2	30395542
Pubmed	Optimal CD8+ T-cell memory formation following subcutaneous cytomegalovirus infection requires virus replication but not early dendritic cell responses.	XCR1 ZBTB46	5.38e-05	3	148	2	34003499
Pubmed	Nuanced role for dendritic cell intrinsic IRE1 RNase in the regulation of antitumor adaptive immunity.	XCR1 ERN1	5.38e-05	3	148	2	37346037
Pubmed	Vitamin D mediates the relationship between placental cathelicidin and group B streptococcus colonization during pregnancy.	CYP27B1 CUBN	5.38e-05	3	148	2	28622535
Pubmed	Genetic Analysis of SCN11A, SCN10A, and SCN9A in Familial Episodic Pain Syndrome (FEPS) in Japan and Proposal of Clinical Diagnostic Criteria.	SCN11A SCN10A	5.38e-05	3	148	2	38999942
Pubmed	An Ionizable Lipid Material with a Vitamin E Scaffold as an mRNA Vaccine Platform for Efficient Cytotoxic T Cell Responses.	XCR1 ZBTB46	5.38e-05	3	148	2	37814788
Pubmed	Yield of peripheral sodium channels gene screening in pure small fibre neuropathy.	SCN11A SCN10A	5.38e-05	3	148	2	30554136
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ABCC3 FRAS1 EPPK1 PGAP3 POLRMT MED14 RAP1GAP2 SRGAP2 TRRAP TRIM7 CPTP HEYL ZNF592 ZNF324B ALOX5	7.92e-05	1105	148	15	35748872
Pubmed	Genetic variation in SCN10A influences cardiac conduction.	AOC1 SCN10A	1.07e-04	4	148	2	20062061
Pubmed	Interaction of 5-lipoxygenase with cellular proteins.	DICER1 ALOX5	1.07e-04	4	148	2	10051563
Pubmed	Behavioral abnormalities observed in Zfhx2-deficient mice.	ZFHX2 ZFHX3	1.07e-04	4	148	2	23300874
Pubmed	Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.	EPPK1 ZSWIM5 CCDC110 MED14 VPS13D NPHP3 GLUD2 NAV3 MMS19 KLHL4	1.60e-04	564	148	10	21565611
Pubmed	Type I Interferon Delivery by iPSC-Derived Myeloid Cells Elicits Antitumor Immunity via XCR1+ Dendritic Cells.	XCR1 IRF3	1.78e-04	5	148	2	31577946
Pubmed	Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function.	SCN11A SCN10A	1.78e-04	5	148	2	37117223
Pubmed	Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication.	MED14 UBASH3A TRIM7 PSMD6 NPHP3 UMODL1 AQR	2.21e-04	283	148	7	18854154
Pubmed	Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons.	SCN11A SCN10A	2.67e-04	6	148	2	16029194
Pubmed	Multimodal control of dendritic cell functions by nociceptors.	ZBTB46 SCN10A	2.67e-04	6	148	2	36996219
Pubmed	An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways.	SCN11A SCN10A	2.67e-04	6	148	2	23711479
Pubmed	Notch2-dependent DC2s mediate splenic germinal center responses.	STAT4 ZBTB46	2.67e-04	6	148	2	30279176
Pubmed	Lymph node medulla regulates the spatiotemporal unfolding of resident dendritic cell networks.	XCR1 ZBTB46	2.67e-04	6	148	2	37463581
Pubmed	Sterile liver injury induces a protective tissue-resident cDC1-ILC1 circuit through cDC1-intrinsic cGAS-STING-dependent IL-12 production.	XCR1 STAT4	2.67e-04	6	148	2	36807146
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	CAPN2 POLRMT TRRAP DICER1 CYFIP1 NUP160	3.07e-04	212	148	6	33853758
Pubmed	A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils.	XCR1 ZBTB46	3.72e-04	7	148	2	30926233
Pubmed	Vitamin D.	CYP27B1 CUBN	3.72e-04	7	148	2	15951480
Pubmed	TRIM7 inhibits encephalomyocarditis virus replication by activating interferon-β signaling pathway.	IRF3 TRIM7	3.72e-04	7	148	2	37023504
Pubmed	T cell fate following Salmonella infection is determined by a STING-IRF1 signaling axis in mice.	IRF3 ZBTB46	3.72e-04	7	148	2	31840109
Pubmed	Dicer is required for embryonic angiogenesis during mouse development.	FLT1 DICER1	3.72e-04	7	148	2	15613470
Pubmed	Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling.	SESN3 RRAGD	3.72e-04	7	148	2	25259925
Pubmed	Localization of STRO-1, BMP-2/-3/-7, BMP receptors and phosphorylated Smad-1 during the formation of mouse periodontium.	ACVR1 BMP3	3.72e-04	7	148	2	17662325
Pubmed	Dicer cleavage by calpain determines platelet microRNA levels and function in diabetes.	CAPN2 DICER1	3.72e-04	7	148	2	25944670
Pubmed	Pain without nociceptors? Nav1.7-independent pain mechanisms.	SCN11A SCN10A	3.72e-04	7	148	2	24440715
Pubmed	Type 1 conventional dendritic cells maintain and guide the differentiation of precursors of exhausted T cells in distinct cellular niches.	XCR1 ZBTB46	3.72e-04	7	148	2	35366396
Pubmed	Congenital Insensitivity to Pain Overview	SCN11A ZFHX2	3.72e-04	7	148	2	29419974
Pubmed	A role for Piezo2 in EPAC1-dependent mechanical allodynia.	SCN11A SCN10A	3.72e-04	7	148	2	23575686
Pubmed	HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP.	TRRAP DICER1 ZNF169	4.10e-04	34	148	3	25925205
Pubmed	Epigenetic patterns at the mouse prolyl oligopeptidase gene locus suggest the CpG island in the gene body to be a novel regulator for gene expression.	FLT1 PREP	4.95e-04	8	148	2	20600704
Pubmed	Significant determinants of mouse pain behaviour.	SCN11A SCN10A	4.95e-04	8	148	2	25101983
Pubmed	The linkage map of sheep Chromosome 6 compared with orthologous regions in other species.	CCNA2 BMP3	4.95e-04	8	148	2	8661727
Pubmed	A ubiquitin-based effector-to-inhibitor switch coordinates early brain, craniofacial, and skin development.	KLHL1 KLHL22 VPS13D KLHL4	5.33e-04	87	148	4	37495603
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	POLRMT MED14 TRRAP DICER1 ZNF592 MMS19 NUP160 AQR	6.21e-04	440	148	8	34244565
Pubmed	International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.	SCN11A SCN10A	6.35e-04	9	148	2	16382098
Pubmed	Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes.	IRF3 UBASH3A	6.35e-04	9	148	2	17599067
Pubmed	Update on the Kelch-like (KLHL) gene family.	KLHL1 KLHL22 KLHL4	7.15e-04	41	148	3	23676014
Pubmed	Indoleamine 2,3-dioxygenase 1 activation in mature cDC1 promotes tolerogenic education of inflammatory cDC2 via metabolic communication.	XCR1 ZBTB46	7.91e-04	10	148	2	35704993
Pubmed	Genome-wide linkage scans for type 2 diabetes mellitus in four ethnically diverse populations-significant evidence for linkage on chromosome 4q in African Americans: the Family Investigation of Nephropathy and Diabetes Research Group.	ZNF7 PREP	7.91e-04	10	148	2	19795399
Pubmed	Common variants associated with general and MMR vaccine-related febrile seizures.	CAPN2 ANO3	7.91e-04	10	148	2	25344690
Pubmed	Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations.	ZNF169 GIPR	7.91e-04	10	148	2	22344221
Pubmed	A Large-scale genetic association study of esophageal adenocarcinoma risk.	ABCC3 FLT1 CAPN2 CYP27B1 CCNA2 UGT1A4 ALOX5	7.96e-04	351	148	7	20453000
Pubmed	Proteomic analysis of the mouse liver mitochondrial inner membrane.	SLC25A42 SRGAP2 TK2 GLUD2 UQCRQ	9.43e-04	175	148	5	12865426
Pubmed	Sequence- and target-independent angiogenesis suppression by siRNA via TLR3.	FLT1 IRF3	9.65e-04	11	148	2	18368052
Pubmed	Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	GREB1L ZFHX2 KIAA1755 KLHL4	9.68e-04	102	148	4	11214970
Pubmed	Topical application of aminoglycoside antibiotics enhances host resistance to viral infections in a microbiota-independent manner.	XCR1 IRF3	1.15e-03	12	148	2	29632368
Pubmed	Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.	SDHAF1 USP30 SLC25A42 CYP27B1 POLRMT NARS2 TTC19 VPS13D FARS2 TK2 GLUD2 UQCRQ TMEM143	1.18e-03	1136	148	13	34800366
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	USP30 BBS1 TRRAP DICER1 CCNA2 KLHL22 PSMD6 GLA FARS2 MMS19 NUP160 AQR	1.28e-03	1005	148	12	19615732
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	EPPK1 CYP27B1 MC2R IRF3 CUBN ATAT1 DICER1 NARS2 CCNA2 DENND1B DPEP2 ANO3 ABHD16A MYBPC1	1.29e-03	1293	148	14	15342556
Pubmed	UGT1A1 is a major locus influencing bilirubin levels in African Americans.	KLHL1 UGT1A4	1.36e-03	13	148	2	22085899
Pubmed	Congenital Hepatic Fibrosis Overview ─ RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	BBS1 NPHP3 TMEM231	1.43e-03	52	148	3	20301743
Pubmed	Mapping brain gene coexpression in daytime transcriptomes unveils diurnal molecular networks and deciphers perturbation gene signatures.	ZSWIM6 KCNH4 TRANK1	1.51e-03	53	148	3	36265442
Pubmed	Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circulating bilirubin levels.	MROH2A UGT1A4	1.58e-03	14	148	2	21646302
Pubmed	Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS.	NARS2 FARS2	1.58e-03	14	148	2	15779907
Pubmed	Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.	UCK1 GLA SENP5	1.60e-03	54	148	3	26288249
Pubmed	Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3.	MED14 TRRAP	1.82e-03	15	148	2	18418385
Pubmed	Selective disruption of trigeminal sensory neurogenesis and differentiation in a mouse model of 22q11.2 deletion syndrome.	SCN11A SCN10A	1.82e-03	15	148	2	33722956
Pubmed	Deletion of the sclerotome-enriched lncRNA PEAT augments ribosomal protein expression.	BMP3 HEYL	1.82e-03	15	148	2	27986952
Pubmed	Polymorphisms in innate immunity genes and risk of childhood leukemia.	ICAM3 STAT4 CCR4 ALOX5 ABHD16A	1.94e-03	206	148	5	20438785
Pubmed	Risk of meningioma and common variation in genes related to innate immunity.	ICAM3 STAT4 CCR4 ALOX5 ABHD16A	1.98e-03	207	148	5	20406964
Pubmed	Common variation in genes related to innate immunity and risk of adult glioma.	ICAM3 STAT4 CCR4 ALOX5 ABHD16A	2.02e-03	208	148	5	19423540
Pubmed	Y Chromosome Infertility	USP9Y CDY2A	2.08e-03	16	148	2	20301513
Pubmed	Molecular heterogeneity of developing retinal ganglion and amacrine cells revealed through single cell gene expression profiling.	CACNA1B ZFHX3	2.08e-03	16	148	2	17444492
Pubmed	Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression.	XCR1 ZBTB46	2.08e-03	16	148	2	32895539
Pubmed	Cross-Regulation of Two Type I Interferon Signaling Pathways in Plasmacytoid Dendritic Cells Controls Anti-malaria Immunity and Host Mortality.	IRF3 ZBTB46	2.08e-03	16	148	2	27793594
Pubmed	Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.	EPPK1 USP9Y KLHL22 GLA ASPM PIP4K2B UQCRQ KLHL4	2.10e-03	533	148	8	25544563
Pubmed	Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci.	ZFP90 MAS1 ZNF7	2.27e-03	61	148	3	8662221
Pubmed	Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.	UBASH3A STAT4	2.35e-03	17	148	2	21383967
Pubmed	ASPM regulates symmetric stem cell division by tuning Cyclin E ubiquitination.	CCNA2 ASPM	2.35e-03	17	148	2	26581405
Pubmed	Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors.	FLT1 HEYL	2.35e-03	17	148	2	22615585
Pubmed	A molecular analysis of matrix remodeling and angiogenesis during long bone development.	FLT1 BMP3	2.35e-03	17	148	2	11165481
Pubmed	The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription.	MED14 CCNA2	2.35e-03	17	148	2	16109376
Pubmed	Comprehensive analysis of low-abundance proteins in human urinary exosomes using peptide ligand library technology, peptide OFFGEL fractionation and nanoHPLC-chip-MS/MS.	AOC1 CUBN	2.35e-03	17	148	2	21082674
Pubmed	Functional screen identifies regulators of murine hematopoietic stem cell repopulation.	NBEA STAT4	2.63e-03	18	148	2	26880577
Pubmed	A systematic study of nuclear interactome of C-terminal domain small phosphatase-like 2 using inducible expression system and shotgun proteomics.	EPPK1 NUP160	2.63e-03	18	148	2	26674342
Pubmed	Generalist genes analysis of DNA markers associated with mathematical ability and disability reveals shared influence across ages and abilities.	FRAS1 SRGAP2	2.63e-03	18	148	2	20602751
Pubmed	An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo.	SCN11A SCN10A	2.63e-03	18	148	2	31666509
Pubmed	Mapping the interactome of HPV E6 and E7 oncoproteins with the ubiquitin-proteasome system.	KLHL1 IRF3 KLHL22 KLHL4	2.93e-03	138	148	4	28786561
Pubmed	Type I Interferon Response Dysregulates Host Iron Homeostasis and Enhances Candida glabrata Infection.	IRF3 STAT4	2.93e-03	19	148	2	32075740
Interaction	SCN11A interactions	CACNA1B SCN11A NALCN SCN10A	3.21e-06	15	144	4	int:SCN11A
Cytoband	3p22.2	SCN11A TRANK1 SCN10A	6.32e-05	24	148	3	3p22.2
Cytoband	6q22	PREP DSE	2.85e-04	8	148	2	6q22
Cytoband	Ensembl 112 genes in cytogenetic band chr3p22	SCN11A TRANK1 SCN10A CCR4 DLEC1	3.41e-04	184	148	5	chr3p22
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN11A SCN10A	1.02e-03	9	98	2	1203
GeneFamily	Zinc fingers SWIM-type\|Mitogen-activated protein kinase kinase kinases	ZSWIM5 ZSWIM6	1.02e-03	9	98	2	90
GeneFamily	Kelch like\|BTB domain containing	KLHL1 KLHL22 KLHL4	1.52e-03	42	98	3	617
ToppCell	P28-Mesenchymal-mesenchymal_fibroblast-mesenchymal_progenitor_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	EFCAB5 MYCBPAP BMP3 MFAP5 ASPM DLEC1 TMEM231	8.18e-07	154	147	7	44d4d99b08216c0901e3bc32743fa0a8b85b5149
ToppCell	RSV-Healthy-2\|Healthy / Virus stimulation, Condition and Cluster	LCN12 RAP1GAP2 CCNA2 ASPM UQCRQ SKA1 NSMCE4A	1.92e-06	175	147	7	c47440c0b0513e67fe13b85f10dd8a8d42d0e9a3
ToppCell	RSV-Healthy-2\|RSV / Virus stimulation, Condition and Cluster	LCN12 RAP1GAP2 CCNA2 ASPM UQCRQ SKA1 NSMCE4A	1.92e-06	175	147	7	0e97189585b7afaf3bd622c3ef10c86412393829
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC3 SCN11A PPFIBP2 BMP3 NAV3 SYTL1 ALOX5	2.50e-06	182	147	7	678eadd57e7e830fc2bf9fd35616d3badce01705
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell-Papillary_Tip_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC3 SCN11A PPFIBP2 BMP3 NAV3 SYTL1 ALOX5	2.50e-06	182	147	7	8d1229fa5aa6e2e38f2ac6fe4f4dc89752fe9344
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1B FRAS1 NDST4 USP9Y SCN10A DMBT1	8.79e-06	145	147	6	96712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1B FRAS1 NDST4 USP9Y SCN10A DMBT1	1.65e-05	162	147	6	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 MAS1 PSG11 KCNH4 CCR4 KLHL4	1.83e-05	165	147	6	6a621b300442c52adfc15b61d3a6d3a3cb00099f
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 MROH2A CUBN KCNH4 TRANK1 NALCN	2.10e-05	169	147	6	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPPK1 KLHL1 NDST4 KCNS3 ANO3 ALOX5	2.17e-05	170	147	6	17bd7fd25a2657cb536ad47e294332920f759e95
ToppCell	facs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l15\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ATAT1 TMEM196 HEYL NAV3 KIAA1755 DLEC1	2.32e-05	172	147	6	de4961f4037c439d3e0ec706a257b0ec17f4d5be
ToppCell	390C-Fibroblasts-Fibroblast-B_(Myofibroblast)\|390C / Donor, Lineage, Cell class and subclass (all cells)	ABCC3 MXRA5 NDST4 COL6A5 SYDE1 KIAA1755	2.64e-05	176	147	6	852d3da0907fe87c0ef23d75a63ce07619cf0c54
ToppCell	390C-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	ABCC3 MXRA5 NDST4 COL6A5 SYDE1 KIAA1755	2.64e-05	176	147	6	d2df1e435996c51213e88270af9f928e9e09a6f5
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CCNA2 TMEM196 MFAP5 HEYL ASPM SKA1	2.72e-05	177	147	6	4197cf2b1e743230c821f422836fa5991b155a52
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_2\|356C / Donor, Lineage, Cell class and subclass (all cells)	USP30 SLC25A42 PKD1L1 ZBTB46 DENND1B CCR4	2.81e-05	178	147	6	8b939659f713eea50a1a6e28b571f680ca0b4c12
ToppCell	Entopeduncular-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendendrocytes_NG2_cells_(Tnr-Cspg5)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	MROH2A PKD1L1 SYTL1 SKA1 MYBPC1	3.09e-05	109	147	5	87f647cfebbb7de725e434cc27058e1c6accbb90
ToppCell	Entopeduncular-Macroglia-POLYDENDROCYTE-P3-Tnr\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	MROH2A PKD1L1 SYTL1 SKA1 MYBPC1	3.09e-05	109	147	5	e3696d84da1dcd15f15d0434ea9d1955f2af22d6
ToppCell	Entopeduncular-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendendrocytes_NG2_cells_(Tnr-Cspg5)-\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	MROH2A PKD1L1 SYTL1 SKA1 MYBPC1	3.09e-05	109	147	5	6678036ff66c825a18d2506e33be421c27cf82e1
ToppCell	Entopeduncular-Macroglia-POLYDENDROCYTE-P3\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	MROH2A PKD1L1 SYTL1 SKA1 MYBPC1	3.09e-05	109	147	5	c9d1e69f9841135f4d114563a293a69a8ba5f965
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-1\|TCGA-Skin / Sample_Type by Project: Shred V9	XCR1 DOCK8 ICAM3 UBASH3A STAT4 CCR4	3.28e-05	183	147	6	cd00e2cd901df4b3f5f7aed747cc0b47f6d3c811
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-Proliferating_T_cell-proliferating_T\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	UBASH3A CCNA2 ASPM KIAA1755 SYTL1 SKA1	3.38e-05	184	147	6	1edefa2a049d7e22d0bdb1ea3d7ef1c8d6ae0fe3
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 MROH2A TRANK1 TRPM3 NAV3 ANO3	3.38e-05	184	147	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-Proliferating_T_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	UBASH3A CCNA2 ASPM KIAA1755 SYTL1 SKA1	3.38e-05	184	147	6	8578c50eaa8ce1cefc0228185c66c8e25f4bfc32
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 MROH2A TRANK1 TRPM3 NAV3 ANO3	3.38e-05	184	147	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 MROH2A TRANK1 TRPM3 NAV3 ANO3	3.38e-05	184	147	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	USP30 SLC25A42 PGAP3 PKD1L1 ZBTB46 DENND1B	3.48e-05	185	147	6	e06a784a297f357f3f8e761c24fa70722048ab42
ToppCell	Ciliated_cells-B-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	MYCBPAP C1orf141 GIPR DNAH12 DLEC1 TMEM231	3.70e-05	187	147	6	2b4262c2e7c7830a976be168cee6eeb738d4feda
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HEYL NALCN NAV3 KIAA1755 ANO3 KLHL4	4.16e-05	191	147	6	107113b930d9ad171f1b2aa20df4567c94fae7d8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HEYL NALCN NAV3 KIAA1755 ANO3 KLHL4	4.16e-05	191	147	6	bc353a79a1d11ca52bba5e3874a80d432e1a7715
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NBEA C1orf141 GIPR DNAH12 DLEC1 TMEM231	4.54e-05	194	147	6	4a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Calb2-Excitatory_Neuron.Slc17a7.Calb2-Vgll3_(Dentate_hilum?)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	MROH2A USP9Y SCN10A MYBPC1	4.63e-05	60	147	4	aa75fef294803ec6396c7d2c1f51d52bc4a5b43f
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Calb2-Excitatory_Neuron.Slc17a7.Calb2-Vgll3_(Dentate_hilum?)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	MROH2A USP9Y SCN10A MYBPC1	4.63e-05	60	147	4	069fbabfd0e48e5809ff01a026439fd0bd017779
ToppCell	COVID-19-kidney-Epithelial_(Imm)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CYP27B1 NDST4 CUBN TMEM196 TRPM3	4.71e-05	119	147	5	7cde7c73bb71f5e1911706e51c2ea6dcc72930ac
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MYCBPAP GIPR DNAH12 ZFHX2 DLEC1 TMEM231	4.95e-05	197	147	6	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	Mild_COVID-19-T/NK-CD4+_T_1\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	ERN1 ICAM3 UBASH3A STAT4 CCR4 SYTL1	4.95e-05	197	147	6	98fca0a2e2f66525c5c9d6cdaebcad14b4d53da4
ToppCell	Mild-Lymphoid-T-CCR7+_T\|Mild / Condition, Lineage, Cell class and cell subclass	ICAM3 UBASH3A STAT4 TRANK1 CCR4 SYTL1	4.95e-05	197	147	6	f23bd8f6ad011730699a5bb7211cd0feeaebc42b
ToppCell	Severe_COVID-19-T/NK-CD4+_T_1\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	ERN1 ICAM3 SESN3 STAT4 CCR4 SYTL1	5.09e-05	198	147	6	bc6b983fdb9547ef8a9e693bc15fced1b73e101f
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_ciliated-Deuterosomal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DNAH12 UMODL1 ASPM ZFHX2 DLEC1 TMEM231	5.09e-05	198	147	6	f31790442ef142f1c0c49bf3daf2d0efb193d2c9
ToppCell	BAL-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_1\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	ERN1 ICAM3 SESN3 STAT4 CCR4 SYTL1	5.09e-05	198	147	6	32ec322ed144c545014b191da5274d12feeaf96b
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|Control_saline / Treatment groups by lineage, cell group, cell type	CMTM2 CYP27B1 COL6A5 UCK1 MFAP5 SKA1	5.09e-05	198	147	6	0c4d2c68a42f8a9e964e2dd28092fe75f5216834
ToppCell	BAL-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_1-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ERN1 ICAM3 SESN3 STAT4 CCR4 SYTL1	5.09e-05	198	147	6	1e281d8f0291e8cf814e9e5abd7f5860402a7c77
ToppCell	BAL-Severe-Lymphocyte-T/NK-CD4+_T\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	ERN1 ICAM3 UBASH3A STAT4 CCR4 SYTL1	5.23e-05	199	147	6	4669b6be3b513d80b6f79bd10a1974fefdf58093
ToppCell	LPS_anti-TNF-Hematopoietic_Myeloid-Granulocytic_cells-Mast-cells\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	ERN1 PPFIBP2 UBASH3A GLA ANO3 ALOX5	5.38e-05	200	147	6	0b02f3ca3d8612ed7af46381195b0ed5591313cf
ToppCell	Hematolymphoid-Microglia-TYROBP----L1-3\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	DOCK8 SRGAP2 ZSWIM6 CYFIP1 NAV3 ALOX5	5.38e-05	200	147	6	a20dce14f94777687aad57d6fbe3258ad376f63f
ToppCell	Hematolymphoid-Microglia-TYROBP--\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	DOCK8 SRGAP2 ZSWIM6 CYFIP1 NAV3 ALOX5	5.38e-05	200	147	6	dc344b3ec51d506952e38f0b3a7795d65f9dd4eb
ToppCell	Hematolymphoid-Microglia-TYROBP-\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	DOCK8 SRGAP2 ZSWIM6 CYFIP1 NAV3 ALOX5	5.38e-05	200	147	6	3bba5219453322198e8fdb0921d5f8c403598751
ToppCell	Hematolymphoid-Microglia\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	DOCK8 SRGAP2 ZSWIM6 CYFIP1 NAV3 ALOX5	5.38e-05	200	147	6	21bcca3b670fe9bac034aef2275d3de4a9a73e2b
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Monocytic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ABCC3 DOCK8 RAP1GAP2 SRGAP2 DPEP2 ALOX5	5.38e-05	200	147	6	8872d5fa101d413fb43b4231d476878678543035
ToppCell	Hematolymphoid-Microglia-TYROBP---\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	DOCK8 SRGAP2 ZSWIM6 CYFIP1 NAV3 ALOX5	5.38e-05	200	147	6	a8646d0fca99f10827c2d2a12e584660ef7155f1
ToppCell	Hematolymphoid-Microglia-TYROBP\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	DOCK8 SRGAP2 ZSWIM6 CYFIP1 NAV3 ALOX5	5.38e-05	200	147	6	33036d21c1c82109284473a515c4f890b33fdd5c
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	TMEM196 DNAH12 KCNS3 HCRTR1	9.47e-05	72	147	4	7877184d5c9dd6d96476d71e7504e58c0b4d0f26
ToppCell	LPS-IL1RA-Hematopoietic_Mast-Mast_cells-T-cells\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1B UBASH3A STAT4 DPEP2 CCR4	9.51e-05	138	147	5	10c263c58b83a018791f77098f18927d904cb13b
ToppCell	facs-Heart-Unknown-3m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EFCAB5 FRAS1 MROH2A CYP27B1 TRANK1	1.05e-04	141	147	5	4aa4b3476dc5abefbd348353cfe711cd5fe3d52f
ToppCell	facs-Heart-Unknown-3m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EFCAB5 FRAS1 MROH2A CYP27B1 TRANK1	1.05e-04	141	147	5	e40c6f1b7fbaa46b3eaa55f1b37ef360b04370a8
ToppCell	facs-Heart-Unknown-3m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EFCAB5 FRAS1 MROH2A CYP27B1 TRANK1	1.09e-04	142	147	5	759fbbd15b4fb313bd6269b7f087edafebd530ef
ToppCell	PND01-03-samps-Mesenchymal-Myofibroblast-myofibroblast_-_immature_2\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	KLHL1 ZSWIM5 MFAP5 UMODL1 KIAA1755	1.12e-04	143	147	5	abe6ec0f6956b87f394d537926eb2427fcfad93f
ToppCell	LPS-IL1RA+antiTNF-Hematopoietic_Mast-Mast_cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1B UBASH3A STAT4 DPEP2 CCR4	1.24e-04	146	147	5	a5c84ad44d6ffb25028a4fd5454fd5de81b16a5e
ToppCell	LPS-IL1RA+antiTNF-Hematopoietic_Mast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1B UBASH3A STAT4 DPEP2 CCR4	1.24e-04	146	147	5	8133037881c15e75637fc616091a7055488dd5fc
ToppCell	LPS-antiTNF-Hematopoietic_Mast-Mast_cells-T-cells\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1B UBASH3A STAT4 DPEP2 SYTL1	1.28e-04	147	147	5	1ecd7c084e73eb6fae1ab1f9aae17115d3d62cbd
Disease	Leigh Syndrome due to Mitochondrial Complex V Deficiency	NARS2 TTC19 FARS2 UQCRQ	2.92e-05	36	145	4	C1850600
Disease	Necrotizing encephalopathy, infantile subacute, of Leigh	NARS2 TTC19 FARS2 UQCRQ	2.92e-05	36	145	4	C2931891
Disease	Leigh Syndrome due to Mitochondrial Complex III Deficiency	NARS2 TTC19 FARS2 UQCRQ	2.92e-05	36	145	4	C1850598
Disease	Leigh Syndrome Due To Mitochondrial Complex II Deficiency	NARS2 TTC19 FARS2 UQCRQ	2.92e-05	36	145	4	C1850597
Disease	Leigh Syndrome due to Mitochondrial Complex IV Deficiency	NARS2 TTC19 FARS2 UQCRQ	2.92e-05	36	145	4	C1850599
Disease	LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY	NARS2 TTC19 FARS2 UQCRQ	3.26e-05	37	145	4	C1838951
Disease	Primary Erythermalgia	SCN11A SCN10A	7.17e-05	3	145	2	C0014805
Disease	PAROXYSMAL EXTREME PAIN DISORDER	SCN11A SCN10A	7.17e-05	3	145	2	C1833661
Disease	Leigh Disease	NARS2 TTC19 FARS2 UQCRQ	8.47e-05	47	145	4	C0023264
Disease	pulse pressure measurement	MXRA5 INPP5B NBEA KCNH4 CCNA2 GIPR ZBTB46 CYFIP1 TRANK1 DENND1B TRPM3 COMMD7 SCN10A KIAA1755 ZFHX3 DLEC1 NUP160 SOS2	1.70e-04	1392	145	18	EFO_0005763
Disease	beta-hydroxybutyric acid measurement	MSGN1 KCNS3	3.55e-04	6	145	2	EFO_0010465
Disease	Digitotalar Dysmorphism	NALCN MYBPC1	3.55e-04	6	145	2	C1852085
Disease	ARTHROGRYPOSIS, DISTAL, TYPE 1	NALCN MYBPC1	3.55e-04	6	145	2	C0220662
Disease	response to ketamine	SCN11A DOCK8 PPFIBP2 ZFHX3	3.77e-04	69	145	4	EFO_0009748
Disease	severe acute respiratory syndrome, COVID-19	ABCC3 XCR1 MXRA5 KLHL1 RAP1GAP2 SRGAP2 FARS2 ZFHX3 KLHL4	3.83e-04	447	145	9	EFO_0000694, MONDO_0100096
Disease	creatinine measurement	ARMC9 CUBN CCNA2 GIPR ZBTB46 DUOX1 RRAGD ZNF592 COMMD7 KIAA1755 KCNS3 ZFHX3 DLEC1 SOS2	4.09e-04	995	145	14	EFO_0004518
Disease	Congenital Pain Insensitivity	SCN11A SCN10A	4.96e-04	7	145	2	C0002768
Disease	Hereditary Sensory Autonomic Neuropathy, Type 5	SCN11A SCN10A	4.96e-04	7	145	2	C0020075
Disease	metastatic colorectal cancer, survival time	MSGN1 KCNS3	6.59e-04	8	145	2	EFO_0000714, EFO_1001480
Disease	Unilateral agenesis of kidney	FRAS1 GREB1L	6.59e-04	8	145	2	C0266294
Disease	sick sinus syndrome	SCN10A ZFHX3	6.59e-04	8	145	2	MONDO_0001823
Disease	familial sick sinus syndrome	SCN10A ZFHX3	6.59e-04	8	145	2	MONDO_0012061
Disease	MITOCHONDRIAL COMPLEX III DEFICIENCY (disorder)	TTC19 UQCRQ	6.59e-04	8	145	2	C1852372
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	FLT1 ERN1 MSGN1 NAV3 ALOX5	8.42e-04	148	145	5	C0279702
Disease	Distal arthrogryposis	NALCN MYBPC1	8.44e-04	9	145	2	cv:C0265213
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN11A SCN10A	1.05e-03	10	145	2	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN11A SCN10A	1.05e-03	10	145	2	DOID:0080422 (implicated_via_orthology)
Disease	hepatocellular carcinoma	STAT4 CCR4 DLEC1	1.08e-03	41	145	3	EFO_0000182
Disease	Secondary Biliary Cholangitis	ICAM3 STAT4 DENND1B	1.16e-03	42	145	3	C0238065
Disease	Biliary cirrhosis	ICAM3 STAT4 DENND1B	1.16e-03	42	145	3	C0023892
Disease	Biliary Cirrhosis, Primary, 1	ICAM3 STAT4 DENND1B	1.16e-03	42	145	3	C4551595
Disease	insomnia, bilirubin measurement	MROH2A UGT1A4	1.28e-03	11	145	2	EFO_0004570, EFO_0004698
Disease	QT interval	FRAS1 AOC1 C1orf141 ZNF592 PREP SCN10A KIAA1755 ZFHX3 NUP160	1.34e-03	534	145	9	EFO_0004682
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN11A SCN10A	1.53e-03	12	145	2	DOID:0060170 (implicated_via_orthology)
Disease	pancreatic cancer (is_marker_for)	ABCC3 ACVR1 CCR4 ALOX5	1.58e-03	101	145	4	DOID:1793 (is_marker_for)
Disease	Primary biliary cirrhosis	ICAM3 STAT4 DENND1B	1.61e-03	47	145	3	C0008312
Disease	T wave morphology measurement	PREP SCN10A	2.10e-03	14	145	2	EFO_0008398
Disease	MMR-related febrile seizures	CAPN2 ANO3	2.41e-03	15	145	2	EFO_0006519
Disease	Polydactyly	FRAS1 BBS1 NPHP3 TMEM231	2.70e-03	117	145	4	C0152427
Disease	Spermatogenic Failure, Nonobstructive, Y-Linked	USP9Y CDY2A	2.75e-03	16	145	2	C1839071
Disease	Spermatogenic failure, Y-linked, 2	USP9Y CDY2A	2.75e-03	16	145	2	cv:C1839071
Disease	SPERMATOGENIC FAILURE, Y-LINKED, 2	USP9Y CDY2A	2.75e-03	16	145	2	415000
Disease	Myopia	SCN11A FRAS1 KLHL1 BMP3 MFAP5 TRPM3 ANO3	3.02e-03	385	145	7	HP_0000545
Disease	X-21441 measurement	ABCC3 UGT1A4	3.11e-03	17	145	2	EFO_0800814
Disease	sphingomyelin 14:0 measurement	TRPM3 ZFHX3	3.11e-03	17	145	2	EFO_0010390
Disease	Meckel syndrome type 1	NPHP3 TMEM231	3.48e-03	18	145	2	C3714506
Disease	schizophrenia, inflammatory bowel disease	IRF3 ZSWIM6	3.48e-03	18	145	2	EFO_0003767, MONDO_0005090
Disease	Sarcomatoid Renal Cell Carcinoma	FLT1 MSGN1 NAV3 ALOX5	3.73e-03	128	145	4	C1266043
Disease	Chromophobe Renal Cell Carcinoma	FLT1 MSGN1 NAV3 ALOX5	3.73e-03	128	145	4	C1266042
Disease	Collecting Duct Carcinoma of the Kidney	FLT1 MSGN1 NAV3 ALOX5	3.73e-03	128	145	4	C1266044
Disease	Papillary Renal Cell Carcinoma	FLT1 MSGN1 NAV3 ALOX5	3.73e-03	128	145	4	C1306837
Disease	Renal Cell Carcinoma	FLT1 MSGN1 NAV3 ALOX5	3.73e-03	128	145	4	C0007134
Disease	Global developmental delay	CACNA1B NBEA TRRAP TRPM3	4.27e-03	133	145	4	C0557874
Disease	obesity (implicated_via_orthology)	CAPN2 BBS1 STAT4 ZFHX2 ZFHX3	4.28e-03	215	145	5	DOID:9970 (implicated_via_orthology)
Disease	Seizures	CACNA1B NBEA TRRAP NARS2 TRPM3	4.54e-03	218	145	5	C0036572
Disease	gestational age	PREP DLEC1 HCRTR1 SENP5	4.87e-03	138	145	4	EFO_0005112

Protein segments in the cluster

Peptide	Gene	Start	Entry
TFHVRVYRGMELLRS	UMODL1	341	Q5DID0
ASFILRTDHYIMARV	TMEM62	421	Q0P6H9
RTDHYIMARVLFVLI	TMEM62	426	Q0P6H9
VSEHMLRLYDRYSTV	BMP3	56	P12645
MHFTIRLTESAITYR	CDY2A	271	Q9Y6F7
YVRMLLLTKNRFSSH	C1orf141	216	Q5JVX7
IRVFNYNTLERVHMF	COPB2	81	P35606
QITSYLVAHTLGRRM	ABHD16A	206	O95870
FRETELYNTVMLRHE	ACVR1	246	Q04771
VQFSHAMDTLLFRLY	HTR3C	416	Q8WXA8
HMSLALNRTGRSIVY	GLA	186	P06280
YIHINLFTSFMLRAA	GIPR	171	P48546
MTTIHYDRITSLQRA	AQR	326	O60306
MSIDRYLAIVHAVFS	CCR4	131	P51679
RTYRLQIHSMADQVL	AOC1	591	P19801
QMLELITRLHQYIFS	DICER1	841	Q9UPY3
TNLLRRFCHYIVTMR	CACNA1B	1136	Q00975
RAATFIQSTFRMHRL	ASPM	2336	Q8IZT6
SNATRSRIVYHMLER	ANO3	301	Q9BYT9
GNLTRMRHVISYSLS	UQCRQ	6	O14949
MRHVISYSLSPFEQR	UQCRQ	11	O14949
AHRLNTIMDYTRVLV	ABCC3	1481	O15438
RMRTLADALHTLRNY	MSGN1	136	A6NI15
LSVMEAYHLSFERRQ	ANKRD27	611	Q96NW4
MTQTLKYASRVFHRV	CYP27B1	1	O15528
ILAIMYVFASHHFRR	DUOX1	1201	Q9NRD9
FDLRTTMLYICERHF	DUOX1	1461	Q9NRD9
HMRFISELARYSNSE	CYFIP1	356	Q7L576
MVLDSIYFSRRFHVR	FRAS1	3256	Q86XX4
MRRNPFTVYITHLSI	MAS1	61	P04201
NYSVIVMFTALQLHR	MAGT1	71	Q9H0U3
YTQFALMLSRRHTSR	LCN12	126	Q6JVE5
LTHFYMAAERQRTDL	KIAA1755	941	Q5JYT7
VDRHTVYNIITNFMR	MMS19	146	Q96T76
HSTSDVVRQYMARLI	ARMC9	381	Q7Z3E5
RYFNLLMEHHRIILS	NAV3	2041	Q8IVL0
RMNLVIFRYVLEHLS	DNAH12	2226	Q6ZR08
AIIQRMYSRRSLYHS	KCNH4	476	Q9UQ05
TRSLFQYMFLVQRHF	DSE	266	Q9UL01
RIRLLSHLNSYAAEM	HEYL	146	Q9NQ87
RDIYAQRMHTFITSL	KCNS3	441	Q9BQ31
IAILESSRFQYHMVI	NDST4	96	Q9H3R1
SETLRTLSEMRHYQR	GREB1L	536	Q9C091
LMERSIHSARYIFVE	TK2	131	O00142
DRYLVVLATVRSRHM	NPBWR2	141	P48146
HRLVLSAVSDYFAAM	KLHL4	196	Q9C0H6
FHESRVDRRMLQYLT	PPFIBP2	651	Q8ND30
HQLCFTSLRRMYIVN	MFAP5	106	Q13361
TIVLALMYVFREHQR	ICAM3	501	P32942
EFLLHRAYSELMVLT	MED14	56	O60244
TPNYSVSRLIFVRHM	PREP	481	P48147
HMRTVTNYFIVNLSL	HCRTR1	76	O43613
VMYLRFRSDNSPTHV	CUBN	2311	O60494
ALLELFYDHSSQMLR	EFCAB5	411	A4FU69
FYDHSSQMLRSLLRN	EFCAB5	416	A4FU69
LRDTVASALMYHRNE	KLHL22	266	Q53GT1
EQYRRNTVLTTMHAF	DOCK8	1911	Q8NF50
MHINVAVETLRYLTF	ERN1	241	O75460
RFDYRTHLTIGMREL	COL6A5	1356	A8TX70
YRSLQAMVAHELSNR	CPTP	76	Q5TA50
MYLQVETRTSSRLHL	CYBC1	1	Q9BQA9
QFYSFLHEMERVRTS	COMMD7	181	Q86VX2
SASRMQSNRHVVYIL	ATAT1	66	Q5SQI0
ALFLYTHRRMAITGD	INPP5B	51	P32019
HSLDNSLSILRTFYM	DPEP2	191	Q9H4A9
NVHRIMTRYTLVFNS	FAM186A	76	A6NE01
VNYIDRFLSSMSVLR	CCNA2	236	P20248
TAMHRAFQTDLYLLR	BBS1	446	Q8NFJ9
MSFSDFLRHYSRLEI	CAPN2	326	P17655
HYFRLMVSRPFSVSQ	DLEC1	1516	Q9Y238
SYNRMTIHFRSDISF	DMBT1	1851	Q9UGM3
YASMLHERRIVIISS	DENND1B	206	Q6P3S1
HRMQLSETNRTLFLF	PSG11	191	Q9UQ72
YMEALARLHLTVTRA	RRAGD	151	Q9NQL2
EMHSLRAEALYRLSL	POLRMT	771	O00411
SIFRSDSALQYHLML	PKD1L1	2511	Q8TDX9
VHSALAYTMERSARQ	GLUD2	506	P49448
HRRMRTVTNYFIVNL	TACR2	61	P21452
NLSDRSRQAYTFHLM	PHYHD1	251	Q5SRE7
MIRSHFTHIFALVRY	GARNL3	321	Q5VVW2
VREMRIHAYSQLLES	PSMD6	296	Q15008
MLIFSYVIFLHSLRN	OR4C16	211	Q8NGL9
NSNYERTHSRIMILS	MT-ND4	331	P03905
MLTVHVSYLSLIRFD	PGAP3	206	Q96FM1
SLTDRGVMSYVRHVL	IRF3	251	Q14653
VSRTFHIMFANLYIV	OR52H1	276	Q8NGJ2
VALSRNHFSLVMYEL	MROH2A	151	A6NES4
LRLVSSFHAYNRMTP	SYDE1	536	Q6ZW31
RRSLSPVFNHTMVYD	SYTL1	466	Q8IYJ3
IRSMFRKLHNSYTDV	TRAPPC2L	96	Q9UL33
SVYTTFRDREIMFHV	RAP1GAP2	321	Q684P5
MAALISLHYRSTLDR	SOS2	536	Q07890
IHRLSESMAQVYRGS	TDRD6	276	O60522
MNSVTRNLYHRFIDE	SKA1	186	Q96BD8
RTHLVSEVFGIAMYR	ALOX5	371	P09917
SLYRLVLHSIRESMA	NPHP3	746	Q7Z494
NSQSRRHLAEFYMIE	NARS2	246	Q96I59
YTTIRRVGTVLQLMH	NBEA	631	Q8NFP9
TYMVVTRNVFSHRLT	PIP4K2B	196	P78356
RMYRTHTRRALQTVA	EPPK1	2141	P58107
SSFDMLRYVETLLTH	NSMCE4A	156	Q9NXX6
MSRHSRLQRQVLSLY	SDHAF1	1	A6NFY7
MYSNIFHVFIRISRE	SLC25A42	166	Q86VD7
ALRTVYERLAHASIM	OSCP1	76	Q8WVF1
HYSTLMSRRVCIQLV	OR8U3	131	Q8NH85
IESRARAVDLMTHNY	NUP160	1066	Q12769
TIFHALRYHSIVTMR	MC2R	131	Q01718
EFEMRHLQREYLSLS	CCDC110	761	Q8TBZ0
FAVRSRRSMNLHYLL	CMTM2	166	Q8TAZ6
SDLLYLLDMVVRFHT	CNGA4	76	Q8IV77
SIFFLTIMTIHRYLS	XCR1	116	P46094
LSNLAAVLMHRERYT	TTC19	321	Q6DKK2
LSMIRFRYRILRSQH	SENP5	236	Q96HI0
SYEQRRMFSEREHSL	TMEM196	136	Q5HYL7
THSQLFTIARYMELR	ZSWIM5	996	Q9P217
LVFYSQEIRDMFHLR	UCK1	141	Q9HA47
AVEDMRHLYTFRVNF	TRIM7	476	Q9C029
YETNISRNLRIHMTS	ZFHX2	576	Q9C0A1
RSAQALELAHMLYYR	TMEM143	331	Q96AN5
HRSLRTMSYRGTFQE	SULT4A1	146	Q9BR01
AYRSYVLHRSMALSN	SCN10A	1861	Q9Y5Y9
VDTTMLRRALFNYVH	SESN3	396	P58005
QRTHMLERVTFLIYN	STAT4	296	Q14765
SMHRFLTISRLEELY	TRPM3	536	Q9HCF6
RDYMVLAAHFQRTTE	ZNF592	721	Q92610
TTLIIMRYLFAFLNH	SRGAP2	611	O75044
SELLMHTGETYRRIQ	MYCBPAP	231	Q8TBZ2
FTHRTDYNSLDRIMA	TMEM168	331	Q9H0V1
YFLERSHSARMTLAK	USP9Y	2456	O00507
FSFRERMTHKSLVYL	ZDHHC16	256	Q969W1
SYTQLFTIARYMEHR	ZSWIM6	1026	Q9HCJ5
QLILTFSYRLHRMAT	TMEM231	136	Q9H6L2
FSYRLHRMATLVMQS	TMEM231	141	Q9H6L2
SFISPASIRRYMVTH	ZNF491	111	Q8N8L2
LLFYERVLSRMQHQS	USP30	496	Q70CQ3
LAIRVSVHSLFSMFI	SCN11A	121	Q9UI33
THRSLFFILMVLRDV	VN1R17P	181	Q8TDU5
LYRHFREIESRLQLM	TRANK1	2541	O15050
LLRTVNNRTMHYSIS	FLT1	591	P17948
ITYRHMERTLSQREV	FARS2	416	O95363
FVASLIRHYTMVAVA	TRRAP	1041	Q9Y4A5
RTLYREVMLENYSHL	ZNF169	36	Q14929
IIDFMYSAHLALTSR	ZBTB46	86	Q86UZ6
RALYREVMLENHSSV	ZNF7	26	P17097
RSLYRDVMLENYSHL	ZFP90	36	Q8TF47
RDMRFVHYQTLRALF	UBASH3A	271	P57075
YETNVARNLRIHMTS	ZFHX3	811	Q15911
YRHVMLENFTLVTSL	ZNF324B	26	Q6AW86
FETEHLLKRYSRSMA	UGT1A4	101	P22310
RVSLRMASVQYVHTQ	VPS13D	1966	Q5THJ4
HRLVLSSVSDYFAAM	KLHL1	226	Q9NR64
HDVLSMLSYRSVDIR	NALCN	1531	Q8IZF0
RLSTIRHLYLAENMV	MXRA5	181	Q9NR99
RRIINDLANTSHVYM	MXRA5	616	Q9NR99
FERHSRVYTFEMQII	MYBPC1	116	Q00872