Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	cell-cell contact zone	FLOT2 ANK2 PKP4 OBSCN OBSL1 KCNJ11 CTNNB1	1.96e-05	94	184	7	GO:0044291
GeneOntologyCellularComponent	intercalated disc	ANK2 OBSCN OBSL1 KCNJ11 CTNNB1	3.33e-04	68	184	5	GO:0014704
GeneOntologyCellularComponent	C-fiber	SCN10A PRPH	4.57e-04	4	184	2	GO:0044299
GeneOntologyCellularComponent	AP-5 adaptor complex	AP5B1 AP5Z1	4.57e-04	4	184	2	GO:0044599
GeneOntologyCellularComponent	acrosomal vesicle	FLOT2 ZPBP PRAMEF22 PRAMEF19 PRAMEF18 KCNJ11 NXF2 RND2	4.94e-04	206	184	8	GO:0001669
GeneOntologyCellularComponent	basolateral plasma membrane	FLOT2 EPPK1 ANK2 MAP7 SLCO5A1 CLCN2 PKD1 KCNQ1 STK39 CTNNB1	5.63e-04	320	184	10	GO:0016323
HumanPheno	Abnormality of the philtrum	HSPG2 CCDC22 ATRX IFT172 CEP290 RTTN OBSL1 CHSY1 GRIA3 PIGG HUWE1 NEB AP4S1 KIDINS220 ADSL NALCN KCNJ11 BUB1B KMT2A TTI1 CTNNB1 PHIP KDM4B	4.32e-06	726	61	23	HP:0000288
HumanPheno	Abnormal upper lip morphology	HSPG2 CCDC22 ATRX PDGFRA IFT172 CEP290 RTTN OBSL1 CHSY1 EVC GRIA3 PIGG HUWE1 NEB IL1RAPL1 AP4S1 KIDINS220 ADSL NALCN KCNJ11 BUB1B KMT2A CDK5RAP2 TTI1 CTNNB1 PHIP KDM4B	6.27e-06	980	61	27	HP:0000177
HumanPheno	Aggressive behavior	HSPG2 RELN ATRX CEP290 RTTN GRIA3 IL1RAPL1 CLCN2 ADSL NALCN SLC25A13 KMT2A TTI1 ATXN10 CTNNB1 PHIP KDM4B GABRA1	1.93e-05	516	61	18	HP:0000718
HumanPheno	Abnormal aggressive, impulsive or violent behavior	HSPG2 RELN ATRX CEP290 RTTN GRIA3 IL1RAPL1 CLCN2 ADSL NALCN SLC25A13 KMT2A TTI1 ATXN10 CTNNB1 PHIP KDM4B GABRA1	1.93e-05	516	61	18	HP:0006919
HumanPheno	Abnormality of globe location or size	HSPG2 BNC2 RELN CCDC22 ATR ATRX IFT172 CEP290 RTTN GLYCTK CHSY1 EVC GRIA3 PIGG HUWE1 NEB IL1RAPL1 AP4S1 KIDINS220 NALCN BUB1B KCNQ1 KMT2A CDK5RAP2 MACF1 CTNNB1 GNRHR PHIP TAFAZZIN HELLS	2.27e-05	1246	61	30	HP:0000489
HumanPheno	Abnormality of globe location	HSPG2 BNC2 RELN CCDC22 ATRX IFT172 CEP290 RTTN GLYCTK CHSY1 EVC GRIA3 PIGG HUWE1 NEB IL1RAPL1 AP4S1 KIDINS220 NALCN BUB1B KCNQ1 KMT2A CDK5RAP2 MACF1 GNRHR PHIP TAFAZZIN HELLS	2.69e-05	1122	61	28	HP:0100886
HumanPheno	Abnormality of the lower urinary tract	HSPG2 BNC2 CCDC22 ATR ATRX IFT172 CEP290 RTTN OBSL1 EVC PIGG HUWE1 NEB AP5Z1 SLC25A13 BUB1B PKD1 FBXO7 KCNQ1 CDK5RAP2 TTI1 MACF1 ATXN10 GABRA1	9.65e-05	937	61	24	HP:0010936
Domain	ARM-like	SMG1 RIPOR2 CAND2 ATR PKP4 RTTN PSMD2 HEATR1 HUWE1 PIK3R4 PPP4R3B ELMO3 RPTOR AP5Z1 MROH7 TTI1 ATXN10 CTNNB1 HECTD1 IPO11	2.15e-12	270	182	20	IPR011989
Domain	ARM-type_fold	SMG1 RIPOR2 CAND2 ATR IFT172 PKP4 UBR4 RTTN PSMD2 HEATR1 HUWE1 PIK3R4 PPP4R3B ELMO3 RPTOR MROH7 TTI1 ATXN10 CTNNB1 HECTD1 IPO11	1.78e-11	339	182	21	IPR016024
Domain	-	RIPOR2 CAND2 ATR PKP4 RTTN PSMD2 HEATR1 PIK3R4 RPTOR AP5Z1 MROH7 TTI1 ATXN10 CTNNB1 HECTD1 IPO11	5.69e-10	222	182	16	1.25.10.10
Domain	HEAT_REPEAT	SMG1 CAND2 ATR HEATR1 PIK3R4 MROH7 IPO11	5.31e-06	70	182	7	PS50077
Domain	HEAT	CAND2 ATR HEATR1 PIK3R4 RPTOR IPO11	2.10e-05	58	182	6	IPR000357
Domain	P-loop_NTPase	ATRX MYO7B MFHAS1 ATAD5 KIF26B RNF112 WRN DHX57 CHD1L KATNA1 TEP1 MYO3A SPATA17 DQX1 EIF4A1 ABCC12 RND2 GFM1 SEPTIN12 HELLS NLRP5	8.32e-05	848	182	21	IPR027417
Domain	Helicase_C	ATRX WRN DHX57 CHD1L DQX1 EIF4A1 HELLS	9.05e-05	108	182	7	IPR001650
Domain	HELICASE_CTER	ATRX WRN DHX57 CHD1L DQX1 EIF4A1 HELLS	9.60e-05	109	182	7	PS51194
Domain	HELICASE_ATP_BIND_1	ATRX WRN DHX57 CHD1L DQX1 EIF4A1 HELLS	9.60e-05	109	182	7	PS51192
Domain	DEXDc	ATRX WRN DHX57 CHD1L DQX1 EIF4A1 HELLS	9.60e-05	109	182	7	SM00487
Domain	HEAT	CAND2 ATR HEATR1 PIK3R4 RPTOR	1.01e-04	48	182	5	PF02985
Domain	Helicase_ATP-bd	ATRX WRN DHX57 CHD1L DQX1 EIF4A1 HELLS	1.02e-04	110	182	7	IPR014001
Domain	IQ_motif_EF-hand-BS	RASGRF2 MYO7B OBSCN MYO3A SPATA17 SCN10A	2.49e-04	90	182	6	IPR000048
Domain	IQ	RASGRF2 MYO7B OBSCN MYO3A SPATA17 SCN10A	2.98e-04	93	182	6	PS50096
Domain	Helicase_C	ATRX WRN DHX57 CHD1L EIF4A1 HELLS	6.31e-04	107	182	6	PF00271
Domain	HELICc	ATRX WRN DHX57 CHD1L EIF4A1 HELLS	6.31e-04	107	182	6	SM00490
Domain	IQ	MYO7B OBSCN MYO3A SPATA17 SCN10A	6.44e-04	71	182	5	PF00612
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	SMG1 ATR ATRX PKP4 OBSL1 DHX57 CC2D1B PATL1 GMIP XAB2 CEMIP2 PIK3R4 IBTK AP5B1 EIF4A1 BUB1B KMT2A TNFAIP2 QSOX2 SORL1 HELLS	5.74e-11	650	186	21	38777146
Pubmed	5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.	SMG1 CAND2 ATR RPTOR TTI1 ATXN10	5.82e-09	27	186	6	23027611
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	RELN ANK2 ATRX IFT172 UBR4 CEP290 ANKS1B OBSL1 PSMD2 POLE4 HUWE1 XAB2 SMYD2 PIK3R4 PPP4R3B EIF4A1 ZNF197 PKD1 FBXO7 MACF1 ATXN10 SGSM3 RAPGEF2 CABIN1 HECTD1 DOP1B	6.24e-09	1285	186	26	35914814
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	HSPG2 EPPK1 LPAR5 MFHAS1 UBR4 RTTN OBSCN CHSY1 PIGG HUWE1 TEP1 AP4S1 SYNE3 SH3TC1 RPTOR KCNJ11 TMEM132A PKD1 TNFAIP2 CABIN1 HECTD1 TTC38	1.34e-07	1105	186	22	35748872
Pubmed	Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.	SMG1 ATR RPTOR TTI1	2.54e-07	11	186	4	20427287
Pubmed	Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.	HSPG2 CPPED1 EPPK1 LYPLA2 PKP4 UBR4 PSMD2 HEATR1 NEB TGM3 MYO3A ADSL EIF4A1 SLC25A13 MACF1 STK39 DHRS2 CTNNB1	7.48e-07	844	186	18	25963833
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	CAND2 ACAA1 LPAR5 PRAMEF22 PRAMEF19 ANKS1B CC2D1B C10orf90 PRAMEF18 SMYD2 GPR107 FBXO7 MROH7 CDK5RAP2 STK39 KDM7A PLD5 ATXN10 DHRS2 GFM1 KDM4B DOP1B	9.51e-07	1242	186	22	30973865
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	TNK1 FLOT2 PHACTR2 PDGFRA KIF26B MAP7 ARHGEF16 PIK3R4 WWC2 INA RPTOR PHACTR4 BUB1B KMT2A MACF1 RAPGEF2 HECTD1 DOP1B	9.94e-07	861	186	18	36931259
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SMG1 CAND2 MARCHF6 CHSY1 CEMIP2 GPR107 PPP4R3B IBTK RPTOR AP5Z1 CDK5RAP2 KDM7A ARHGAP20 KDM4B	1.13e-06	529	186	14	14621295
Pubmed	Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy.	CCDC22 LPAR5 HEATR1 XAB2 PIK3R4 ADSL RPTOR SLC25A13 TTI1 TAF7 MED7 TAFAZZIN BRF2	1.16e-06	454	186	13	33226137
Pubmed	Duplication and positive selection among hominin-specific PRAME genes.	PRAMEF22 PRAMEF19 PRAMEF18	1.49e-06	5	186	3	16159394
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	EPPK1 UBR4 DHX57 PSMD2 HEATR1 HUWE1 XAB2 TGM3 INA EIF4A1 SLC25A13 KMT2A MACF1 HECTD1 PHIP	2.67e-06	653	186	15	22586326
Pubmed	Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest.	ATR ATRX WRN	2.97e-06	6	186	3	17118963
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	SMG1 PHACTR2 ANK2 ATRX PCDHGB2 NHSL2 PCDHGA4 UBR4 ANKS1B RDH12 DHX57 PSMD2 GRIA3 CC2D1B HEATR1 NEB INA EIF4A1 SLC25A13 KMT2A MACF1 CDK5R2 PRPH	3.10e-06	1442	186	23	35575683
Pubmed	LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.	ATRX CC2D1B FAM13B SYNE3 RPTOR SCN10A QSOX2 SEPTIN12	3.69e-06	168	186	8	30631154
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	RIPOR2 CAND2 ATRX PRAMEF22 PRAMEF19 OBSCN HEATR1 PATL1 HUWE1 FAM171B PRAMEF18 WWC2 AP4S1 TCP11L2 FBXO7 CDK5RAP2 MACF1 EXOC3L1 QSOX2	6.38e-06	1084	186	19	11544199
Pubmed	A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.	SMG1 ATR TTI1	8.26e-06	8	186	3	20810650
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	ANK2 ANKS1B CHSY1 GRIA3 INA MACF1 PLCL1 CTNNB1 RAPGEF2	9.16e-06	251	186	9	27507650
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	RIPOR2 CYP27C1 UBR4 MARCHF6 PSMD2 C10orf90 NEB SCN10A MACF1 HECTD1	1.02e-05	322	186	10	26514267
Pubmed	Scanning the human proteome for calmodulin-binding proteins.	ATRX PSMD2 HUWE1 NEB DMXL1 PHACTR4	1.05e-05	92	186	6	15840729
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	CCDC22 ATAD5 CEP290 CHD1L HUWE1 MAP7 ADSL BUB1B KMT2A CABIN1 MED7 PHIP KDM4B HELLS	1.10e-05	645	186	14	25281560
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	DAGLB CAND2 UBR4 OBSL1 CHSY1 PSMD2 HEATR1 HUWE1 KIDINS220 RPTOR EIF4A1 ATXN10 CTNNB1 HECTD1 QSOX2 IPO11 HELLS	1.38e-05	942	186	17	31073040
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	PRAMEF22 PRAMEF19 PRAMEF18 NLRP5	1.47e-05	28	186	4	25089626
Pubmed	CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons.	RELN PCDHGB2 PCDHGA4 PCDHA1 TAF7	1.51e-05	58	186	5	30377227
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	FLOT2 CAND2 ANK2 ATRX ATAD5 PKP4 GNB1L UBR4 OBSL1 HEATR1 MAP7 CEMIP2 DMXL1 SYNE3 KIDINS220 PHACTR4 BUB1B CDK5RAP2 MACF1 ATXN10 CTNNB1 HELLS	1.66e-05	1487	186	22	33957083
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	RASGRF2 PAXX OBSCN DHX57 NEB PIK3R4 FBXO22 SLC25A13 KMT2A KDM4B IPO11 HELLS	1.68e-05	497	186	12	36774506
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	EPPK1 ATR ATRX PSMD2 CHD1L HUWE1 MAP7 PIK3R4 EIF4A1 BUB1B MACF1 TNFAIP2 HELLS	1.69e-05	582	186	13	20467437
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	EPPK1 KIDINS220 RPTOR EIF4A1 KMT2A CDK5RAP2 SORL1 NLRP5	1.76e-05	208	186	8	33230847
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	ANK2 NHSL2 PKP4 UBR4 ANKS1B GRIA3 HUWE1 INA RPTOR EIF4A1 CDK5RAP2 MACF1 PLCL1 FRMPD3 CTNNB1 RAPGEF2 CABIN1	1.83e-05	963	186	17	28671696
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	ANK2 PKP4 ANKS1B CHSY1 GRIA3 INA MACF1 PLCL1 RAPGEF2	2.24e-05	281	186	9	28706196
Pubmed	Nervous-tissue-specific elimination of microtubule-actin crosslinking factor 1a results in multiple developmental defects in the mouse brain.	RELN INA MACF1	2.41e-05	11	186	3	20170731
Pubmed	Maternal diabetes alters transcriptional programs in the developing embryo.	ATRX PDGFRA POLE4 PHIP	2.53e-05	32	186	4	19538749
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	HSPG2 ATR MARCHF6 CHSY1 PSMD2 PIGG MAP7 SLC7A11 CEMIP2 GPR107 DMXL1 FBXO22 ADSL TMEM132A TTI1 CTNNB1 HECTD1 QSOX2 SORL1	2.64e-05	1201	186	19	35696571
Pubmed	Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates.	UBR4 MARCHF6 HUWE1 FBXO7 HECTD1	2.84e-05	66	186	5	24811749
Pubmed	FBXO22 protein is required for optimal synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine.	SRR FBXO22	2.84e-05	2	186	2	25336657
Pubmed	Polycystin-1 C-terminal tail associates with beta-catenin and inhibits canonical Wnt signaling.	PKD1 CTNNB1	2.84e-05	2	186	2	18632682
Pubmed	Werner's syndrome protein is phosphorylated in an ATR/ATM-dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycle.	ATR WRN	2.84e-05	2	186	2	12629512
Pubmed	KCNJ11 and KCNQ1 Gene Polymorphisms and Placental Expression in Women with Gestational Diabetes Mellitus.	KCNJ11 KCNQ1	2.84e-05	2	186	2	35893051
Pubmed	Identification of a novel beta-catenin-interacting protein.	CTNNB1 RAPGEF2	2.84e-05	2	186	2	10873669
Pubmed	Stability of GABAA/benzodiazepine receptor alpha 1 subunit mRNA expression in reeler mouse cerebellar Purkinje cells during postnatal development.	RELN GABRA1	2.84e-05	2	186	2	1664786
Pubmed	Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease.	SMYD2 PKD1	2.84e-05	2	186	2	28604386
Pubmed	Mechanical unloading reduces microtubule actin crosslinking factor 1 expression to inhibit β-catenin signaling and osteoblast proliferation.	MACF1 CTNNB1	2.84e-05	2	186	2	29219183
Pubmed	A comparative immunohistochemical analysis of small round cell tumors of childhood: utility of peripherin and alpha-internexin as markers for neuroblastomas.	INA PRPH	2.84e-05	2	186	2	18528283
Pubmed	Positive cross talk between protein kinase D and β-catenin in intestinal epithelial cells: impact on β-catenin nuclear localization and phosphorylation at Ser552.	PKD1 CTNNB1	2.84e-05	2	186	2	26739494
Pubmed	Bidirectional KCNQ1:β-catenin interaction drives colorectal cancer cell differentiation.	KCNQ1 CTNNB1	2.84e-05	2	186	2	28373572
Pubmed	Cereal genes similar to Snf2 define a new subfamily that includes human and mouse genes.	CHD1L HELLS	2.84e-05	2	186	2	12471446
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	BNC2 LPAR5 LYPLA2 PKP4 SRR CHD1L MAP7 TTI1 CTNNB1 HECTD1 TBCEL IPO11	3.51e-05	536	186	12	15840001
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	BNC2 LPAR5 LYPLA2 PKP4 SRR CHD1L MAP7 TTI1 CTNNB1 HECTD1 TBCEL IPO11	3.64e-05	538	186	12	10512203
Pubmed	Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex.	RELN ANK2 ADRA2C EIF4A1	3.64e-05	35	186	4	37758766
Pubmed	Defining the membrane proteome of NK cells.	FLOT2 ACAA1 PDGFRA UBR4 CEP290 MARCHF6 CHSY1 PSMD2 HEATR1 PIGG HUWE1 XAB2 PIK3R4 SYNE3 KIDINS220 EIF4A1 ATXN10 PRPH	6.07e-05	1168	186	18	19946888
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	FLOT2 ANK2 PKP4 ARHGEF16 SLC7A11 CEMIP2 GPR107 KIDINS220 CLCN2 INA PHACTR4 CTNNB1	6.22e-05	569	186	12	30639242
Pubmed	A "double adaptor" method for improved shotgun library construction.	ACAA1 ANK2 UBR4 OBSL1 DHX57 SMYD2 EIF4A1 ASB1 RAPGEF2 KDM4B SORL1 HELLS	6.75e-05	574	186	12	8619474
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	CAND2 IFT172 UBR4 OBSL1 PSMD2 HEATR1 HUWE1 WWC2 FBXO22 KIDINS220 ADSL ATXN10 GFM1 HECTD1 QSOX2 SORL1	7.59e-05	974	186	16	28675297
Pubmed	β-Catenin Stabilization in Skin Fibroblasts Causes Fibrotic Lesions by Preventing Adipocyte Differentiation of the Reticular Dermis.	PDGFRA CTNNB1	8.50e-05	3	186	2	26902921
Pubmed	Association of torsades de pointes with novel and known single nucleotide polymorphisms in long QT syndrome genes.	ANK2 KCNQ1	8.50e-05	3	186	2	17161064
Pubmed	WRN helicase regulates the ATR-CHK1-induced S-phase checkpoint pathway in response to topoisomerase-I-DNA covalent complexes.	ATR WRN	8.50e-05	3	186	2	22159421
Pubmed	Regulation of ClC-2 activity by SPAK and OSR1.	CLCN2 STK39	8.50e-05	3	186	2	25323061
Pubmed	Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML.	ATR KMT2A	8.50e-05	3	186	2	27625305
Pubmed	Two novel CNRs from the CNR gene cluster have molecular features distinct from those of CNR1 to 8.	RELN PCDHA1	8.50e-05	3	186	2	11401448
Pubmed	Identifying the association between single nucleotide polymorphisms in KCNQ1, ARAP1, and KCNJ11 and type 2 diabetes mellitus in a Chinese population.	KCNJ11 KCNQ1	8.50e-05	3	186	2	32922204
Pubmed	Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071.	PKP4 CTNNB1	8.50e-05	3	186	2	10092585
Pubmed	Structural insight into M-band assembly and mechanics from the titin-obscurin-like-1 complex.	OBSCN OBSL1	8.50e-05	3	186	2	20133654
Pubmed	The expansion of the PRAME gene family in Eutheria.	PRAMEF19 PRAMEF18	8.50e-05	3	186	2	21347312
Pubmed	E3 ubiquitin ligase Mule targets β-catenin under conditions of hyperactive Wnt signaling.	HUWE1 CTNNB1	8.50e-05	3	186	2	28137882
Pubmed	ALC1/eIF4A1-mediated regulation of CtIP mRNA stability controls DNA end resection.	CHD1L EIF4A1	8.50e-05	3	186	2	32392243
Pubmed	Obscurin targets ankyrin-B and protein phosphatase 2A to the cardiac M-line.	ANK2 OBSCN	8.50e-05	3	186	2	18782775
Pubmed	Neural control of heart rate is an arrhythmia risk modifier in long QT syndrome.	ADRA2C KCNQ1	8.50e-05	3	186	2	18308161
Pubmed	SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na(+)-K(+)-Cl(-) cotransporter 2.	STK39 SORL1	8.50e-05	3	186	2	20385770
Pubmed	Binding of Myomesin to Obscurin-Like-1 at the Muscle M-Band Provides a Strategy for Isoform-Specific Mechanical Protection.	OBSCN OBSL1	8.50e-05	3	186	2	27989621
Pubmed	T-cell factor/β-catenin activity is suppressed in two different models of autosomal dominant polycystic kidney disease.	PKD1 CTNNB1	8.50e-05	3	186	2	21389971
Pubmed	Cloning genes encoding receptors related to chemoattractant receptors.	GPR32 GPR32P1	8.50e-05	3	186	2	9653656
Pubmed	IPO11 mediates βcatenin nuclear import in a subset of colorectal cancers.	CTNNB1 IPO11	8.50e-05	3	186	2	31881079
Pubmed	Binding of an ankyrin-1 isoform to obscurin suggests a molecular link between the sarcoplasmic reticulum and myofibrils in striated muscles.	ANK2 OBSCN	8.50e-05	3	186	2	12527750
Pubmed	Dual role of K ATP channel C-terminal motif in membrane targeting and metabolic regulation.	ANK2 KCNJ11	8.50e-05	3	186	2	19805355
Pubmed	Psychiatric Risk Gene Transcription Factor 4 Regulates Intrinsic Excitability of Prefrontal Neurons via Repression of SCN10a and KCNQ1.	SCN10A KCNQ1	8.50e-05	3	186	2	26971948
Pubmed	Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism.	OBSCN OBSL1	8.50e-05	3	186	2	31098411
Pubmed	β-catenin stabilization in gonadotropes impairs FSH synthesis in male mice in vivo.	CTNNB1 GNRHR	8.50e-05	3	186	2	25343272
Pubmed	Forced expression of Wnt antagonists sFRP1 and WIF1 sensitizes chronic myeloid leukemia cells to tyrosine kinase inhibitors.	ATR CTNNB1	8.50e-05	3	186	2	28468589
Pubmed	PDGFRα expression distinguishes GFAP-expressing neural stem cells from PDGF-responsive neural precursors in the adult periventricular area.	PDGFRA CTNNB1	8.50e-05	3	186	2	21715615
Pubmed	The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways.	SMG1 ATR	8.50e-05	3	186	2	15279777
Pubmed	A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese.	SRR KCNQ1	8.50e-05	3	186	2	20174558
Pubmed	Molecular basis of the head-to-tail assembly of giant muscle proteins obscurin-like 1 and titin.	OBSCN OBSL1	8.50e-05	3	186	2	20489725
Pubmed	Stimulation of HERG channel activity by β-catenin.	KCNQ1 CTNNB1	8.50e-05	3	186	2	22905262
Pubmed	Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.	PRAMEF22 PRAMEF19 PRAMEF18	9.68e-05	17	186	3	23565261
Pubmed	Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.	PRAMEF22 PRAMEF19 PRAMEF18	9.68e-05	17	186	3	37781892
Pubmed	Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.	ANK2 ANKS1B GRIA3 FAM171B IL1RAPL1 MACF1 GABRA1	9.76e-05	197	186	7	36604605
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	CAND2 OBSL1 POLE4 SRR CHD1L HEATR1 HUWE1 PPP4R3B KIDINS220 RPTOR TTI1 IPO11	1.12e-04	606	186	12	36538041
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	FLOT2 ATAD5 PKP4 OBSL1 MAP7 TEP1 SH3TC1 RPTOR SLC25A13 IL21R MACF1 STK39 RAPGEF2 TAF7 PHIP QSOX2 SORL1	1.13e-04	1116	186	17	31753913
Pubmed	The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.	PRAMEF22 PRAMEF19 PRAMEF18	1.16e-04	18	186	3	23894331
Pubmed	Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.	PRAMEF22 PRAMEF19 PRAMEF18	1.16e-04	18	186	3	39181896
Pubmed	BDNF regulates spontaneous correlated activity at early developmental stages by increasing synaptogenesis and expression of the K+/Cl- co-transporter KCC2.	RELN GRIA3 GABRA1	1.16e-04	18	186	3	12588844
Pubmed	Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.	PRAMEF22 PRAMEF19 PRAMEF18	1.16e-04	18	186	3	12890732
Pubmed	Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.	PRAMEF22 PRAMEF19 PRAMEF18	1.16e-04	18	186	3	29731491
Pubmed	Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.	PRAMEF22 PRAMEF19 PRAMEF18	1.16e-04	18	186	3	14675769
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	EPPK1 SLC25A33 ANKS1B GRIA3 RPTOR MACF1 STK39 CTNNB1 RAPGEF2 PRPH	1.17e-04	430	186	10	32581705
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	FLOT2 EPPK1 RASGRF2 PKP4 HEATR1 HUWE1 GMIP ARHGEF16 FAM13B TGM3 INA KMT2A CTNNB1 ARHGAP20 SORL1	1.32e-04	916	186	15	32203420
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	FLOT2 EPPK1 CEP290 OBSL1 PSMD2 HEATR1 HUWE1 XAB2 INA EIF4A1 SLC25A13 MACF1 ATXN10 CTNNB1 PHIP HELLS	1.35e-04	1024	186	16	24711643
Pubmed	Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.	PRAMEF22 PRAMEF19 PRAMEF18	1.37e-04	19	186	3	28604677
Pubmed	Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes.	ATR RPTOR TTI1	1.37e-04	19	186	3	20801936
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	ATRX ATAD5 PAXX DHX57 HEATR1 INA KMT2A TAF7 PHIP IPO11 HELLS	1.52e-04	533	186	11	30554943
Interaction	HTR6 interactions	SMG1 CAND2 ATR AP4S1 RPTOR TTI1 ATXN10	7.10e-07	58	176	7	int:HTR6
Interaction	NPTN interactions	SMG1 CAND2 ATR SLC25A33 HEATR1 HUWE1 AP5Z1 TTI1 TNFAIP2 SGSM3 IPO11 DOP1B	6.33e-06	278	176	12	int:NPTN
Interaction	MCM2 interactions	HSPG2 CPPED1 EPPK1 ATR ATRX LYPLA2 PKP4 UBR4 OBSL1 PSMD2 HEATR1 HUWE1 NEB TGM3 MYO3A ADSL EIF4A1 SLC25A13 FBXO7 KMT2A MACF1 STK39 DHRS2 CTNNB1 CABIN1	8.14e-06	1081	176	25	int:MCM2
Interaction	GPR182 interactions	CAND2 ATR HEATR1 PIGG GPR107 PIK3R4 KIDINS220 AP5Z1 TTI1 TNFAIP2 QSOX2 TAFAZZIN IPO11 DOP1B HELLS	1.16e-05	455	176	15	int:GPR182
Interaction	TOP3B interactions	HSPG2 EPPK1 LPAR5 MFHAS1 UBR4 RTTN WRN OBSCN CHSY1 DHX57 PATL1 PIGG HUWE1 TEP1 IBTK AP4S1 FBXO22 SYNE3 SH3TC1 RPTOR EIF4A1 SLC25A13 KCNJ11 TMEM132A PKD1 TNFAIP2 CABIN1 HECTD1 TTC38	2.94e-05	1470	176	29	int:TOP3B
Cytoband	5q31	PCDHGB2 PCDHGA4 PCDHA1 FAM13B TAF7	1.19e-04	115	189	5	5q31
GeneFamily	Phosphatase and actin regulators	PHACTR2 PHACTR4	2.77e-04	4	124	2	679
GeneFamily	PRAME family	PRAMEF22 PRAMEF19 PRAMEF18	5.74e-04	24	124	3	686
GeneFamily	EF-hand domain containing\|Plakins	EPPK1 MACF1	1.27e-03	8	124	2	939
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN	ATR ATRX PKP4 MARCHF6 WRN CHSY1 IBTK ADSL SLC25A13 BUB1B STK39 RAPGEF2 PHIP DOP1B	6.63e-06	466	186	14	M13522
ToppCell	343B-Lymphocytic-CD4_T-cell-Treg_cell_4\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	FLOT2 PHACTR2 IFT172 SH3TC1 IL21R ZNF197 KCNQ1 TNFAIP2	1.20e-06	186	186	8	bca5215d406f1785bf3a420201d5686071fcaca5
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN KIF26B RNF112 INA KCNJ11 TMEM132A PLD5 GABRA1	1.24e-06	187	186	8	1b2fdbfb1ce3f19795dfc4b1da5a94f4b057ec41
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	SMG1 MARCHF6 HUWE1 CEMIP2 KMT2A MACF1 CTNNB1 RAPGEF2	1.30e-06	188	186	8	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	HEATR1 HUWE1 CEMIP2 SYNE3 KIDINS220 MACF1 DOP1B HELLS	1.46e-06	191	186	8	9454f642c3621370fa23640b631301346b300950
ToppCell	356C-Fibroblasts-Fibroblast-E\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	NEB TEP1 KIDINS220 SH3TC1 RAPGEF2 ARHGAP20 QSOX2	1.72e-06	136	186	7	edfd453c9a650d69d05a5a3ab15f7df56349fa86
ToppCell	356C-Fibroblasts-Fibroblast-E-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	NEB TEP1 KIDINS220 SH3TC1 RAPGEF2 ARHGAP20 QSOX2	1.72e-06	136	186	7	03e4e2353c23ceffde35b2d0aadd15299e3db09f
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW08-Mesenchymal\|GW08 / Sample Type, Dataset, Time_group, and Cell type.	KIF26B CLCN2 CLYBL SH3TC1 TTI1 TNFAIP2 ARHGAP20 CABIN1	2.06e-06	200	186	8	e5b7d9622b96bb20c81ac76b4e60e8b44fa9cca1
ToppCell	droplet-Marrow-nan-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NHSL2 SLC7A11 IBTK TCP11L2 STK39 KDM7A TBCEL	8.10e-06	172	186	7	d354424c1f861b6607dfd63b9724f4c237b30275
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BNC2 SERPINE3 ANK2 PDGFRA OBSCN IL1RAPL1 PLCL1	9.77e-06	177	186	7	bd602db857f37869ef76d14c05ef522c509f08ee
ToppCell	343B-Lymphocytic-CD4_T-cell-Treg_cell_4\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	FLOT2 IFT172 SH3TC1 IL21R ZNF197 KCNQ1 TNFAIP2	1.21e-05	183	186	7	3cbe0175d05fd39bc430de1ef471ff2c5b56460e
ToppCell	COVID-19-Heart-CM_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ANK2 OBSCN SMYD2 IL1RAPL1 SLCO5A1 GALNT17 NALCN	1.26e-05	184	186	7	e737f0f14c49b07bbb04a165083ac32210bc5690
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	HEATR1 HUWE1 SLC7A11 KIDINS220 MACF1 DOP1B HELLS	1.30e-05	185	186	7	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	HEATR1 HUWE1 SLC7A11 KIDINS220 MACF1 DOP1B HELLS	1.35e-05	186	186	7	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	368C-Lymphocytic-NK_cells-NK_cell_D3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	PKP4 PTGDR AP4S1 CDK5RAP2 TTI1 BRF2 HELLS	1.40e-05	187	186	7	c667fae6440dc98072b584f203d00f0fb1cb2f21
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN RNF112 INA TMEM132A PLD5 FRMPD3 GABRA1	1.49e-05	189	186	7	f57200c93d39c9bce1adba0a6a1c178c028dd86b
ToppCell	Children_(3_yrs)-Immune-natural_killer_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	BNC2 RIPOR2 PTGDR IL21R STK39 TTC38 SORL1	1.71e-05	193	186	7	1cb666375bc4e1b11a146d20896c9b5ae6fd0887
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN RNF112 INA TMEM132A PLD5 FRMPD3 GABRA1	1.71e-05	193	186	7	5fb7808dd971c1cc64c2bd4f8f1de646fb2d77f4
ToppCell	COVID-19-Heart-CM_1\|Heart / Disease (COVID-19 only), tissue and cell type	ANK2 OBSCN SMYD2 SLCO5A1 GALNT17 NALCN PLCL1	1.83e-05	195	186	7	f1ef50331eda8f1239dba6ea970df4eaccf032f1
ToppCell	5'-GW_trimst-2-SmallIntestine-Neuronal-neurons_B-Branch_B1_(eMN)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BNC2 ANK2 ANKS1B INA PLD5 CDK5R2 PRPH	1.95e-05	197	186	7	5593721407f61fc5bc3f2f8bf8fa2604c4e29565
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_basal-Dividing_Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ATAD5 RTTN FAM171B MYO3A EIF4A1 BUB1B HELLS	2.02e-05	198	186	7	d5e125f0c4f41b47d567568d0838adcca7655f6d
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW13-Mesenchymal-Mesoderm\|GW13 / Sample Type, Dataset, Time_group, and Cell type.	TNK1 RASGRF2 CYP27C1 CC2D1B AP4S1 EXOC3L1 BRF2	2.15e-05	200	186	7	0f4b8b0868bda406fe6bf01d1b722510fdfd0168
ToppCell	Mild/Remission-B_intermediate-10\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	ANK2 C10orf90 NEB CEMIP2 PLCL1 CDK5R2	2.32e-05	136	186	6	1b3c6edcbe0eb674d2d9c838e83ebe2b93e3eec1
ToppCell	facs-Trachea-24m-Hematologic-myeloid-granulocyte-granulocyte_l8\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RIPOR2 RDH12 SLC7A11 TNFAIP2 SLC22A20P SORL1	4.49e-05	153	186	6	338684d420b01e32918fa19048ccdda234942ce1
ToppCell	367C-Myeloid-Macrophage-SPP1+_Macrophage_3\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	RASGRF2 RNF112 PIK3R6 RND2 RAPGEF2 ARHGAP20	4.83e-05	155	186	6	335cd798afbaa0a3a3e1dc558a81cfa32da48983
ToppCell	PND07-Immune-Immune_Myeloid-DC-cDC2-cDC2_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RASGRF2 SLC25A33 TEP1 ULK3 SLC25A13 HELLS	4.83e-05	155	186	6	b5d5c38b269e9318970fcce564df1c8ed7a7ccc6
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Radial_glial-gliogenic/outer_RGCs_and_astrocytes\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	GLYCTK CHSY1 GMIP GALNT17 AP5B1 PGBD2	5.19e-05	157	186	6	2c1219ee19a6246a3b9f5c2c1a37f26ea934a822
ToppCell	Adult-Mesenchymal-myofibroblast_cell-D122\|Adult / Lineage, Cell type, age group and donor	SERPINE3 IL1RAPL1 GALNT17 NALCN TMEM132A EXOC3L1	5.37e-05	158	186	6	410fa08c9d880d27e80ec939fa5ba5a41dcb31ab
ToppCell	facs-Lung-ENDOMUCIN-18m-Myeloid-neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RIPOR2 RDH12 SLC7A11 KDM7A TNFAIP2 SORL1	5.37e-05	158	186	6	d43b335e6aa12d84a75b988fbd6127ff1f4af25c
ToppCell	facs-Lung-ENDOMUCIN-18m-Myeloid-Neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RIPOR2 RDH12 SLC7A11 KDM7A TNFAIP2 SORL1	5.37e-05	158	186	6	ab12b29ce51ca2fcac469cc932391217d97145f9
ToppCell	facs-Lung-nan-3m-Myeloid-neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RIPOR2 RDH12 SLC7A11 TNFAIP2 SLC22A20P SORL1	5.56e-05	159	186	6	836c4b5f9a714ffb5a449087ebefdbb37dd3a2a9
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Myeloid-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RIPOR2 SLC25A33 RDH12 SLC7A11 TNFAIP2 SORL1	5.56e-05	159	186	6	a6093b230afdd4d91870d289c6ac91d1856666a3
ToppCell	droplet-Lung-1m-Hematologic-myeloid-neutrophil-neutrophil\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RIPOR2 RDH12 SLC7A11 TNFAIP2 SLC22A20P SORL1	5.56e-05	159	186	6	be54b910ccb73e37eb81945bbad9a89d2bcec34b
ToppCell	droplet-Lung-1m-Hematologic-myeloid-neutrophil\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RIPOR2 RDH12 SLC7A11 TNFAIP2 SLC22A20P SORL1	5.56e-05	159	186	6	178678173b005cb8225472306657f0d8289b133b
ToppCell	facs-Lung-nan-3m-Myeloid-Neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RIPOR2 RDH12 SLC7A11 TNFAIP2 SLC22A20P SORL1	5.56e-05	159	186	6	a6742ba2216427409173aec4e05a537d7fde226c
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	RASGRF2 WRN PIGG GALNT17 IL21R BUB1B	5.56e-05	159	186	6	2233fee5dcdb6c7dee5b1bd8efbc07d86b339927
ToppCell	droplet-Marrow-BM-30m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TEP1 PIK3R6 TCP11L2 KDM7A TNFAIP2 TBCEL	5.76e-05	160	186	6	822adcf5f9208f305cafffd8ed97f3a061e82b03
ToppCell	droplet-Marrow-BM-30m-Myeloid-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TEP1 PIK3R6 TCP11L2 KDM7A TNFAIP2 TBCEL	6.17e-05	162	186	6	76e289ad9fd3694f77fd0d19e74c1cb8e87b8094
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Myeloid-neutrophil\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RIPOR2 RDH12 TGM3 KDM7A FRMPD3 SORL1	6.83e-05	165	186	6	4fe7c3c9370a556cf4e308a2e723b4b907a6cc25
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PDGFRA RNF112 CYP27C1 GRIA3 IL1RAPL1 ARHGAP20	7.80e-05	169	186	6	c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCell	Ionocyte-iono-1\|World / Class top	SLC25A33 PIGG RPTOR KCNQ1 PLCL1 RND2	7.80e-05	169	186	6	4b68bcb4b5fc3cd2db23cd4edace7444aa2d605c
ToppCell	COVID-19-Heart-CM_+_Macrophage\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ANK2 OBSCN SMYD2 SLCO5A1 GALNT17 PLCL1	8.06e-05	170	186	6	3f15242a1d3e4e9871d9170b2ef05842fb609c29
ToppCell	facs-BAT-Fat-3m-Myeloid-granulocyte\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC25A33 RDH12 SLC7A11 TMEM132A TNFAIP2 SORL1	8.06e-05	170	186	6	8fd0a55266066a51266ab616c38c883e2680bcf4
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c5-CD16\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	OR2L5 CHSY1 DMXL1 EXOC3L1 GABRA1	8.27e-05	106	186	5	005ca899efc5ad0c9c17b2697022b594c8cea2c1
ToppCell	10x5'-GI_small-bowel-Lymphocytic_NK-NK_CD16\|GI_small-bowel / Manually curated celltypes from each tissue	BNC2 RIPOR2 PTGDR FRMPD3 TTC38 SORL1	8.32e-05	171	186	6	1ee505b91f15191d294a5d491ecdf154c08b8622
ToppCell	3'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-D_cells_(SST+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZPBP RDH12 NEB DHRS2 GABRA1 KLB	8.32e-05	171	186	6	fa5cc720bd0045d0307439be547b41d56def5b43
ToppCell	droplet-Liver-Npc-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 RASGRF2 CEMIP2 TGM3 ADRA2C SH3TC1	8.59e-05	172	186	6	a6fb1bde8d942c7b5caaf7bd14de0b7ce32fda55
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-neuro-epithelial\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGM3 CBLN4 INA KCNJ11 CDK5R2 PRPH	8.87e-05	173	186	6	07798461d12d04f3dabff03481c999cb07c5af2f
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-neuro-epithelial-N_cells_(NTS+)\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGM3 INA KCNJ11 DHRS2 CDK5R2 PRPH	8.87e-05	173	186	6	f31e738c2b3b319fb40b0b16b2393a51c9a8999c
ToppCell	droplet-Liver-Npc-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 RASGRF2 CEMIP2 TGM3 ADRA2C SH3TC1	9.75e-05	176	186	6	3494ffa8555e6edf4b1250e10434bae9b73ec845
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-neuro-epithelial\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGM3 CBLN4 KCNJ11 DHRS2 CDK5R2 PRPH	9.75e-05	176	186	6	fb718a6b07aa5d56600263280afa530bcb63db42
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nptxr-Excitatory_Neuron.Slc17a7.Nptxr-Drd1_(Deep_layer_pyramidal_cells)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	CCDC22 IFT172 EVC XAB2 CTU1 QSOX2	9.75e-05	176	186	6	3c76a5c4ca2b378667cb155fbb9675519572b35d
ToppCell	droplet-Liver-Npc-18m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 RASGRF2 CEMIP2 TGM3 ADRA2C SH3TC1	9.75e-05	176	186	6	d43f6b7828b98e1dab7b726a5f99499d65a7db80
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RIPOR2 PAXX CEMIP2 PPP4R3B MACF1 TTC38	1.01e-04	177	186	6	d3e6c768b88b7906f3c7fdd00ba20842212c14b1
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RIPOR2 PAXX CEMIP2 PPP4R3B MACF1 TTC38	1.01e-04	177	186	6	f8f101c772c043636bedd6b2ec81409b1d2599bf
ToppCell	COVID-19_Mild-Lymphoid_T/NK-NK_activated\|COVID-19_Mild / Disease group, lineage and cell class	RIPOR2 PAXX CEMIP2 PPP4R3B MACF1 TTC38	1.01e-04	177	186	6	6978a22fef40c8b455342373abe7593f5ede0fa4
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	RIPOR2 PAXX CEMIP2 PPP4R3B MACF1 TTC38	1.01e-04	177	186	6	936ab2b180a052387124f68d0c7f41c0b164e748
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	RIPOR2 PAXX CEMIP2 PPP4R3B MACF1 TTC38	1.01e-04	177	186	6	d5aeda113afaa2425874394610344570c9078478
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATRX ANKS1B GRIA3 ABCC12 ATXN10 KLB	1.01e-04	177	186	6	426a9845df7fd13b02e744532c336c60bc4d4a22
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPPK1 PCDHGA4 AP5B1 CDK5RAP2 PLCL1 ARHGAP20	1.07e-04	179	186	6	b44e2d53b82c3c141bfc6539054b19708200a0d9
ToppCell	COVID-19-Heart-CM_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ANK2 OBSCN SMYD2 SLCO5A1 GALNT17 PLCL1	1.14e-04	181	186	6	719eb532453ab7cd7893726885bc75d74a10b21e
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF26B PCDHGA4 IL1RAPL1 SLCO5A1 GALNT17 TMEM132A	1.14e-04	181	186	6	7af469f5bcb9b1ab3f35b2758bf2afb87e8eba57
ToppCell	Control-Myeloid-DC1\|Control / Condition, Lineage and Cell class	TNK1 HSPG2 LPAR5 PKP4 SLCO5A1 PIK3R6	1.14e-04	181	186	6	5a2a1f017ad23baed9972c68b4a46f4c618ef21a
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BNC2 ANKS1B GRIA3 IL1RAPL1 GALNT17 NALCN	1.21e-04	183	186	6	12daaea821e49bc94a01e2496331e92a80d27339
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN MYO7B KIF26B OBSCN NEB GUCY2F	1.24e-04	184	186	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	Control-Myeloid-DC1\|Myeloid / Condition, Lineage and Cell class	TNK1 HSPG2 LPAR5 PKP4 SLCO5A1 PIK3R6	1.24e-04	184	186	6	b5c1f57f0356969cfb0e1dac764684fc5583bc04
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN MYO7B KIF26B OBSCN NEB GUCY2F	1.24e-04	184	186	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN MYO7B KIF26B OBSCN NEB GUCY2F	1.24e-04	184	186	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	COVID-19-Heart-CM_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ANK2 OBSCN IL1RAPL1 SLCO5A1 GALNT17 PLCL1	1.28e-04	185	186	6	549eeb521c3985bff396ea0f202db21822efa51f
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BNC2 ANKS1B GRIA3 IL1RAPL1 GALNT17 NALCN	1.28e-04	185	186	6	6712512100ccef456d2e2bd201d0987986c92ac9
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BNC2 ANKS1B GRIA3 IL1RAPL1 GALNT17 NALCN	1.28e-04	185	186	6	3b2dfc8f4c87be516265dbecfc251276034d0efd
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	ANK2 OBSCN SMYD2 SLCO5A1 GALNT17 PLCL1	1.28e-04	185	186	6	6baccb26f999145e51b91d94315bf8d4655bef31
ToppCell	5'-GW_trimst-2-SmallIntestine-Neuronal-neurons_B-Branch_B2_(eMN)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KLHL1 ANKS1B INA NALCN CDK5R2 PRPH	1.32e-04	186	186	6	24b23880d4ff8fb4a23e2012d5890b9e2fcf7283
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	BNC2 RELN KIF26B GRIA3 IL1RAPL1 CBLN4	1.32e-04	186	186	6	8915436d09775f2828a7678af203b1082b36e21c
ToppCell	droplet-Limb_Muscle-nan-24m-Macroglial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANKS1B ARHGEF16 IL1RAPL1 FBXO7 DHRS2 GABRA1	1.32e-04	186	186	6	ea936e66ae4b7b40564711fad60ac0137327995f
ToppCell	RV-04._Ventricular_Cardiomyocyte_I\|World / Chamber and Cluster_Paper	OBSCN SMYD2 IL1RAPL1 SLCO5A1 GALNT17 PLCL1	1.36e-04	187	186	6	78cdcf8bc141d3b155c3c8af908431fc419c4d08
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	ANK2 OBSCN SMYD2 IL1RAPL1 GALNT17 PLCL1	1.44e-04	189	186	6	5e80c47f63980904c4c1ff02c201b67b456a0974
ToppCell	facs-Skin-nan-18m-Mesenchymal-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK2 PDGFRA GRIA3 GALNT17 PIK3R6 ARHGAP20	1.44e-04	189	186	6	29287525120be2953b76881ba3cfc4379c265e7a
ToppCell	facs-Skin-nan-18m-Mesenchymal-fibroblast\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK2 PDGFRA GRIA3 GALNT17 PIK3R6 ARHGAP20	1.44e-04	189	186	6	7150dad9a92a715487c2d8130fa01b752ea69663
ToppCell	facs-Skin-nan-18m-Mesenchymal\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK2 PDGFRA GRIA3 GALNT17 PIK3R6 ARHGAP20	1.44e-04	189	186	6	6e4c0effd5192fd00052abc048fdb87a74fb6554
ToppCell	Control-Lymphoid-NK\|World / Disease state, Lineage and Cell class	BNC2 PTGDR CEMIP2 IL21R TTC38 SORL1	1.44e-04	189	186	6	89ef0d0e66dc96cacaae6be7aacdaa884e8e66a8
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	ANK2 OBSCN SMYD2 IL1RAPL1 GALNT17 PLCL1	1.44e-04	189	186	6	0a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCell	Children_(3_yrs)-Immune-natural_killer_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	BNC2 RIPOR2 PTGDR STK39 TTC38 SORL1	1.52e-04	191	186	6	9b8b64a36e27a2523b8730c7922fd7ad865a021e
ToppCell	Children_(3_yrs)-Immune-natural_killer_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	BNC2 RIPOR2 PTGDR IL21R STK39 TTC38	1.52e-04	191	186	6	6345c1aa0fd2f9f2154a44f9393bf7c72bb1f44e
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	BNC2 ANK2 PDGFRA NHSL2 GALNT17 MACF1	1.52e-04	191	186	6	6688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	SMG1 CEMIP2 KMT2A MACF1 PLCL1 SORL1	1.57e-04	192	186	6	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	BNC2 ANK2 PDGFRA NHSL2 GALNT17 MACF1	1.57e-04	192	186	6	99ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_NOS-6\|TCGA-Stomach / Sample_Type by Project: Shred V9	PKP4 PSMD2 PATL1 SLC7A11 TNFAIP2 GFM1	1.57e-04	192	186	6	4e689bca7a242f8482e25f273656e2caba8821c0
ToppCell	Control-B_intermediate-10\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	ANK2 NEB CEMIP2 WWC2 KCNJ11 PLCL1	1.57e-04	192	186	6	224bd958369ba8fa0d7be2126f7dc61c9f6ac19d
ToppCell	facs-Aorta-Heart-3m\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATRX UBR4 CEMIP2 MACF1 TNFAIP2 CTNNB1	1.57e-04	192	186	6	1ccc47792edf9ee23501c8e2165d11271636b66a
ToppCell	nucseq-Immune-Lymphocytic_T/NK-Lymphocytic_T/NK-NK\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	BNC2 PTGDR CEMIP2 IL21R TTC38 SORL1	1.57e-04	192	186	6	a06d5d3c2537f8d2b1dc6b6f3e88a80b5c2a1850
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Stem-like-OPC-like-OPC-like-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NUP210L MYO3A GALNT17 DQX1 ABCC12 ADGRD2	1.61e-04	193	186	6	315840bc48899f3a36d57b19197509de19716e3d
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN PHACTR2 RIPOR2 RASGRF2 KIF26B SYNE3	1.61e-04	193	186	6	d1445b8bf2bab36e1a326ddb2a528151db016c7d
ToppCell	COVID-19-Heart-CM_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	ANK2 OBSCN SMYD2 SLCO5A1 GALNT17 PLCL1	1.61e-04	193	186	6	dd5378a1ef8eb0eda9a3aae62f3c2f3a1402bda0
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN PHACTR2 RIPOR2 RASGRF2 KIF26B SYNE3	1.61e-04	193	186	6	3ed46f5a7419ec4eddbd0df0d9b5f53aa486198b
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN PHACTR2 RIPOR2 RASGRF2 KIF26B SYNE3	1.61e-04	193	186	6	e74fdc8718fe0933e1f4dd3fe37e2134983b99b6
ToppCell	Control-Fibroblasts-Intermediate_pathological_FB\|Control / group, cell type (main and fine annotations)	BNC2 ANK2 PDGFRA NHSL2 KIF26B NALCN	1.66e-04	194	186	6	03a269f75a481ea54aea8e6444605db8d6df493d
ToppCell	COPD-Endothelial-VE_Peribronchial\|Endothelial / Disease state, Lineage and Cell class	BNC2 RASGRF2 MFHAS1 PKP4 SRR HEATR1	1.66e-04	194	186	6	8dcde77767b23e75360adb316cdccf56a00e3726
ToppCell	10x5'-Liver-Lymphocytic_NK\|Liver / Manually curated celltypes from each tissue	BNC2 PAXX PTGDR CEMIP2 TTC38 SORL1	1.66e-04	194	186	6	0b78f4ed84bbaca9f72f005c16c7492bb01d4328
ToppCell	COVID-19-Heart-CM_2\|Heart / Disease (COVID-19 only), tissue and cell type	ANK2 OBSCN SMYD2 SLCO5A1 GALNT17 PLCL1	1.70e-04	195	186	6	75fc81bddb246dca3b437fb60827b1d4fe416405
ToppCell	COVID-19-lung-NK/NKT\|lung / Disease (COVID-19 only), tissue and cell type	BNC2 RIPOR2 PTGDR STK39 TTC38 SORL1	1.70e-04	195	186	6	3ab941a369e3815f338890b116dc77aefa054098
Drug	Loperamide hydrochloride [34552-83-5]; Up 200; 7.8uM; PC3; HT_HG-U133A	MARCHF6 GRIA3 HUWE1 TEP1 ARHGEF16 SLC7A11 FBXO22 KDM7A PRPH	2.32e-05	189	183	9	4672_UP
Drug	Proadifen hydrochloride [62-68-0]; Up 200; 10.2uM; MCF7; HT_HG-U133A	CEP290 TEP1 SLC7A11 KIDINS220 RNF6 DHRS2 RAPGEF2 CABIN1 BRF2	2.53e-05	191	183	9	7165_UP
Drug	vinblastine sulfate; Up 200; 0.1uM; PC3; HT_HG-U133A	TNK1 BNC2 PKP4 CEP290 PPP4R3B SGSM3 CABIN1 TTC38 TAFAZZIN	2.63e-05	192	183	9	7556_UP
Drug	Benzocaine [94-09-7]; Down 200; 24.2uM; PC3; HT_HG-U133A	MFHAS1 ATAD5 MAP7 SLC7A11 CEMIP2 PPP4R3B ASB1 SGSM3 RAPGEF2	2.97e-05	195	183	9	4224_DN
Drug	Dextromethorphan hydrobromide monohydrate [6700-34-1]; Up 200; 10.8uM; MCF7; HT_HG-U133A	RELN INA SH3TC1 AP5Z1 ASB1 RAPGEF2 TTC38 GNRHR KDM4B	2.97e-05	195	183	9	5401_UP
Drug	Flucloxacillin sodium [1847-24-1]; Down 200; 8.4uM; PC3; HT_HG-U133A	TNK1 CPPED1 MFHAS1 PPP4R3B RNF6 TMEM132A SGSM3 TTC38 TAFAZZIN	3.10e-05	196	183	9	5102_DN
Drug	Prazosin hydrochloride [19237-84-4]; Up 200; 9.6uM; HL60; HT_HG-U133A	HSPG2 CEMIP2 FBXO22 ADRA2C CLCN2 INA GALNT8 TTC38 CDK5R2	3.22e-05	197	183	9	3098_UP
Drug	trifluoperazine dihydrochloride; Down 200; 10uM; MCF7; HT_HG-U133A	CPPED1 CEP290 XAB2 GPR107 PHACTR4 ATXN10 SGSM3 CABIN1 BRF2	3.22e-05	197	183	9	6984_DN
Drug	5211181; Down 200; 12uM; MCF7; HT_HG-U133A_EA	TNK1 PHACTR2 CCDC22 EPPK1 AP5Z1 ATXN10 DHRS2 RAPGEF2 TTC38	3.35e-05	198	183	9	950_DN
Drug	Flucloxacillin sodium [1847-24-1]; Up 200; 8.4uM; HL60; HT_HG-U133A	BNC2 RELN OBSL1 SLC7A11 GPR107 KIDINS220 KCNQ1 PLCL1 KDM4B	3.35e-05	198	183	9	3128_UP
Drug	Bemegride [64-65-3]; Down 200; 25.8uM; PC3; HT_HG-U133A	HSPG2 ATAD5 GMIP NEB XAB2 AP5Z1 DHRS2 CABIN1 TTC38	3.35e-05	198	183	9	6668_DN
Drug	Levodopa [59-92-7]; Down 200; 20.2uM; MCF7; HT_HG-U133A	ATAD5 MAP7 XAB2 CLCN2 RNF6 TNFAIP2 SGSM3 CABIN1 TAFAZZIN	3.49e-05	199	183	9	1472_DN
Drug	haloperidol; Down 200; 10uM; MCF7; HT_HG-U133A	ATAD5 PKP4 CEP290 MAP7 CEMIP2 KMT2A DHRS2 TAFAZZIN BRF2	3.49e-05	199	183	9	6963_DN
Disease	lung disease severity measurement	C8orf89 GPR32 GPR32P1 NHSL2 CBLN4 PLCL1	7.60e-05	118	175	6	EFO_0007744
Disease	Romano-Ward Syndrome	ANK2 SCN10A KCNQ1	1.08e-04	16	175	3	C0035828
Disease	Amyotrophic Lateral Sclerosis, Familial	GRIA3 INA GABRA1 PRPH	1.90e-04	48	175	4	C4551993
Disease	Amyotrophic Lateral Sclerosis, Sporadic	GRIA3 INA GABRA1 PRPH	1.90e-04	48	175	4	C1862941
Disease	Juvenile myoclonic epilepsy	CLCN2 GABRA1	2.08e-04	4	175	2	cv:C0270853
Disease	AMYOTROPHIC LATERAL SCLEROSIS 1	GRIA3 INA GABRA1 PRPH	2.23e-04	50	175	4	C1862939
Disease	Adenocarcinoma of lung (disorder)	TNK1 ATR SRR GUCY2F STK39 CTNNB1 HELLS	2.40e-04	206	175	7	C0152013
Disease	Primary microcephaly	RTTN CDK5RAP2 CTNNB1	2.91e-04	22	175	3	C0431350
Disease	medulloblastoma (is_marker_for)	PDGFRA KDM4B	3.46e-04	5	175	2	DOID:0050902 (is_marker_for)
Disease	Idiopathic generalized epilepsy	CLCN2 GABRA1	5.16e-04	6	175	2	cv:C0270850
Disease	long QT syndrome (is_implicated_in)	ANK2 KCNQ1	7.20e-04	7	175	2	DOID:2843 (is_implicated_in)
Disease	remission	HSPG2 RPTOR	7.20e-04	7	175	2	EFO_0009785
Disease	aggressive behaviour measurement, ADHD symptom measurement	MFHAS1 RPTOR KDM7A PLCL1	7.24e-04	68	175	4	EFO_0007826, EFO_0007860
Disease	creatinine measurement	CAND2 KIF26B RNF112 OBSCN EVC PSMD2 NEB ULK3 FBXO22 ADSL AP5B1 KCNQ1 SGSM3 QSOX2 SORL1	9.07e-04	995	175	15	EFO_0004518
Disease	X-11787 measurement	CLYBL HELLS	9.57e-04	8	175	2	EFO_0021258
Disease	syndromic X-linked intellectual disability (implicated_via_orthology)	HUWE1 KDM7A	9.57e-04	8	175	2	DOID:0060309 (implicated_via_orthology)
Disease	Juvenile Myoclonic Epilepsy	CLCN2 GABRA1	9.57e-04	8	175	2	C0270853
Disease	cystic fibrosis (implicated_via_orthology)	CLCN2 ABCC12	1.23e-03	9	175	2	DOID:1485 (implicated_via_orthology)
Disease	cystic kidney disease (implicated_via_orthology)	IFT172 CEP290	1.53e-03	10	175	2	DOID:2975 (implicated_via_orthology)
Disease	Glioma	ATR ATRX DMXL1 CLCN2	1.81e-03	87	175	4	C0017638
Disease	hippocampal CA4 volume	NUP210L GMIP TMEM132A	1.85e-03	41	175	3	EFO_0009396
Disease	Adrenal Gland Neoplasms	CTNNB1 GNRHR	1.86e-03	11	175	2	C0001624
Disease	cognitive decline measurement, memory performance, language measurement	C8orf89 TNFAIP2	1.86e-03	11	175	2	EFO_0004874, EFO_0007710, EFO_0007797
Disease	Adrenal Cancer	CTNNB1 GNRHR	1.86e-03	11	175	2	C0750887
Disease	Childhood Medulloblastoma	PDGFRA CTNNB1 KDM4B	2.13e-03	43	175	3	C0278510
Disease	Melanotic medulloblastoma	PDGFRA CTNNB1 KDM4B	2.13e-03	43	175	3	C1275668
Disease	Medullomyoblastoma	PDGFRA CTNNB1 KDM4B	2.13e-03	43	175	3	C0205833
Disease	Desmoplastic Medulloblastoma	PDGFRA CTNNB1 KDM4B	2.13e-03	43	175	3	C0751291
Disease	Adult Medulloblastoma	PDGFRA CTNNB1 KDM4B	2.13e-03	43	175	3	C0278876
Disease	Myopia	KLHL1 ANKS1B C10orf90 ADRA2C TCP11L2 CTNNB1 RAPGEF2 NLRP5	2.20e-03	385	175	8	HP_0000545
Disease	Intestinal Neoplasms	KCNQ1 CTNNB1	2.22e-03	12	175	2	C0021841
Disease	Intestinal Cancer	KCNQ1 CTNNB1	2.22e-03	12	175	2	C0346627
Disease	Craniofacial Abnormalities	HSPG2 BNC2 ATRX PDGFRA CTNNB1	2.43e-03	156	175	5	C0376634
Disease	mood disorder	RELN SORL1	2.61e-03	13	175	2	EFO_0004247
Disease	Infantile Severe Myoclonic Epilepsy	RAPGEF2 GABRA1	2.61e-03	13	175	2	C0751122
Disease	Bardet-Biedl Syndrome	IFT172 CEP290	2.61e-03	13	175	2	C0752166
Disease	Leber congenital amaurosis (implicated_via_orthology)	CEP290 RDH12	2.61e-03	13	175	2	DOID:14791 (implicated_via_orthology)
Disease	FEV/FEC ratio	HSPG2 BNC2 GNB1L ANKS1B FAM171B NEB CEMIP2 SLCO5A1 WWC2 KDM7A PLCL1 ATXN10 TAF7 ARHGAP20 CTU1 SORL1	2.73e-03	1228	175	16	EFO_0004713
Disease	atrial fibrillation (is_implicated_in)	ANK2 KCNQ1	3.04e-03	14	175	2	DOID:0060224 (is_implicated_in)
Disease	T wave morphology measurement	SCN10A KCNQ1	3.04e-03	14	175	2	EFO_0008398
Disease	polycystic kidney disease (implicated_via_orthology)	IFT172 PKD1	3.04e-03	14	175	2	DOID:0080322 (implicated_via_orthology)
Disease	Medulloblastoma	PDGFRA CTNNB1 KDM4B	3.28e-03	50	175	3	C0025149
Disease	P wave duration	CAND2 SCN10A	3.49e-03	15	175	2	EFO_0005094
Disease	pulse pressure measurement	BNC2 FLOT2 ANK2 PDGFRA MFHAS1 PCDHA1 PIK3R4 ULK3 SPATA17 RPTOR KCNJ11 PHACTR4 PKD1 SCN10A QSOX2 KDM4B KLB	3.91e-03	1392	175	17	EFO_0005763
Disease	Leber congenital amaurosis	CEP290 RDH12	3.97e-03	16	175	2	cv:C0339527
Disease	Ciliopathies	CEP290 RDH12 EVC ATXN10	4.24e-03	110	175	4	C4277690
Disease	protein C measurement	MYO7B CYP27C1	4.49e-03	17	175	2	EFO_0004633
Disease	Autistic Disorder	RELN IL1RAPL1 ADSL STK39 PLD5 GABRA1	4.78e-03	261	175	6	C0004352
Disease	Malignant neoplasm of breast	ANK2 RASGRF2 GNB1L UBR4 OBSCN PIK3R4 INA GUCY2F MROH7 MACF1 EXOC3L1 CTNNB1 CTU1 SORL1	4.96e-03	1074	175	14	C0006142
Disease	Malignant neoplasm of endometrium	ATR CTNNB1	5.03e-03	18	175	2	C0007103
Disease	Carcinoma in situ of endometrium	ATR CTNNB1	5.03e-03	18	175	2	C0346191
Disease	dense area measurement, mammographic density measurement	ADSL SGSM3	5.60e-03	19	175	2	EFO_0005941, EFO_0006503
Disease	response to methotrexate, neurotoxicity	MACF1 PLCL1	5.60e-03	19	175	2	EFO_0011057, GO_0031427

Protein segments in the cluster

Peptide	Gene	Start	Entry
IPALLRLLRKSIDAE	PKP4	616	Q99569
VLAQRRPLAVLKTSE	BUB1B	551	O60566
SRSKVTEEIAIPLRR	ATAD5	716	Q96QE3
KLAREDPALLVAAVR	EXOC3L1	211	Q86VI1
ASRSEVPRLLKLVER	FAM246A	61	A0A494C0Y3
ASRSEVPRLLKLVER	FAM246B	61	A0A494C0N9
ASRSEVPRLLKLVER	FAM246C	61	P0DSO1
VRALLKETLRLFPVL	CYP27C1	401	Q4G0S4
AVPVRLKILLDRLFS	BNC2	181	Q6ZN30
TAPRTIFQRVLDILK	ATXN10	41	Q9UBB4
VAKPDLTSALREIRA	INA	256	Q16352
LVVIAVLTSRALRAP	ADRA2C	71	P18825
LQVFKEARSVPRTLL	ASB1	286	Q9Y576
ANRPKRLLLVLVSAF	GPR32	251	O75388
LRTDKELIATVRRPA	FLOT2	276	Q14254
AVLSREAARRDPKLL	ARHGEF16	111	Q5VV41
KRLPRADAEVSAVRL	C8orf89	81	P0DMQ9
RSQDLIPRASLLLSK	AP5Z1	711	O43299
QALRLKSRAVELLPD	CCDC22	381	O60826
ESRLKRPSVLISALT	CDK5R2	51	Q13319
VVPLSKFVLLRSVDL	DMXL1	1191	Q9Y485
AALLRLKASLAADIP	CLYBL	16	Q8N0X4
TLLLESRPDLLKVVR	CDK5RAP2	786	Q96SN8
RARQVALLPVSLLAS	MROH7	761	Q68CQ1
LRALRFLSVISIVDP	PTGDR	306	Q13258
RSERTDIATLLIPAI	HSPG2	2001	P98160
ARLPRLLVLLAAAAV	QSOX2	31	Q6ZRP7
LILDISRSEVRVKSP	GPR107	121	Q5VW38
EAAPRLRALTLGLAK	PAXX	116	Q9BUH6
ELLLERGAPLLARTK	ANK2	316	Q01484
TNRARILAPLLILDK	AP4S1	126	Q9Y587
PRVSIRKSVDLLHAS	ANKS1B	1216	Q7Z6G8
SPALLLQKEDTVRRL	OBSL1	941	O75147
PGLRARSKVLVTVLD	PCDHGA4	356	Q9Y5G9
NRELKLVAPTLRSEL	PDGFRA	511	P16234
YLLLERLKVSAPARV	RDH12	156	Q96NR8
ERVLTFLPAKALLRV	FBXO22	31	Q8NEZ5
ATRELLRIPQAALAK	PATL1	721	Q86TB9
AELATRAIPELTKLL	CTNNB1	146	P35222
PFLLRRLKSDVALEV	HELLS	446	Q9NRZ9
FLSSRTPVLVARDVK	KIDINS220	1031	Q9ULH0
LRSRVFPSADEIIIK	KDM7A	126	Q6ZMT4
LRFARKPISIIDLIV	KCNQ1	191	P51787
IAEVTIRPDRKILAT	GNB1L	256	Q9BYB4
PEEATRLLAEKRRLA	MAP7	476	Q14244
RSKLVAASVPARDRV	LPAR5	261	Q9H1C0
LRGLPEDISALRALK	MFHAS1	216	Q9Y4C4
ARLLSKLDSEAVPRA	GMIP	941	Q9P107
AALIRSREKPLALIQ	IBTK	1296	Q9P2D0
AIPLLRSDIVRILSA	DOP1B	266	Q9Y3R5
DLLDILIRSPGSIKR	MED7	91	O43513
QPERRKLSALALLSL	IPO11	841	Q9UI26
KISAVSRLLLASPRA	KIF26B	1731	Q2KJY2
ILPASTDILERTIRA	FAM13B	291	Q9NYF5
LEALTLASARGPLRK	KCNJ11	356	Q14654
IARKIASLSRPVVSL	ECHDC3	236	Q96DC8
RADIAVAPLTITLVR	GRIA3	501	P42263
LDLKATQALVLAPTR	EIF4A1	96	P60842
RPSIVFKRDTLLIRE	IL1RAPL1	191	Q9NZN1
PRSLRSLTEDKVLAV	OR2L5	261	Q8NG80
LSVRDLPARKLRVSA	PCDHGB2	56	Q9Y5G2
TVKPELTAALRDIRA	PRPH	256	P41219
RLEPLRALLEKVAAT	PRAMEF18	336	Q5VWM3
LEEELPKRVRSRLSL	KDM4B	1026	O94953
STRKPVIIAVRADLL	MYCLP1	176	P12525
VRKLAAPVISVLLLS	MARCHF6	806	O60337
VSKIDRLSRIAFPLL	GABRA1	416	P14867
IRSLLRKVLLPESFL	NLRP5	391	P59047
RKVLLPESFLIVTVR	NLRP5	396	P59047
ALRRPLLLAATTALA	AP5B1	91	Q2VPB7
SRKLSLRPTVAELQA	PHACTR2	556	O75167
SVLSSPIRREKLALA	PPP4R3B	151	Q5MIZ7
PVIRRSSLLTEKLLR	HUWE1	3441	Q7Z6Z7
PTVAELLARKILRFN	PHACTR4	631	Q8IZ21
SSLVLLLKRRQIAEP	DQX1	411	Q8TE96
EKSLRPAVERLELLL	MACF1	416	Q9UPN3
IALEIPLKARSGSTR	RELN	2276	P78509
AGLPAKAARLVLTRE	IFT172	776	Q9UG01
LAELVPRLFRVASKT	PCDHA1	56	Q9Y5I3
SKASLIVRERPAAII	OBSCN	2816	Q5VST9
LTIRALPARFIEDVK	OBSCN	3531	Q5VST9
KELRLALLAPAELSA	BTBD19	221	C9JJ37
LLLEESDLRRSPRVK	ATRX	646	P46100
AKEPILALRRALLSL	ATR	1896	Q13535
DESRPAVALIRKLIA	HECTD1	956	Q9ULT8
ANLLKRIATIVPRTE	CABIN1	1006	Q9Y6J0
LRAALPRSVKTVLSR	GLYCTK	276	Q8IVS8
SLDRSLAITRPLALK	GNRHR	136	P30968
RLRLPATAEREKLIA	CEP290	1506	O15078
VIPRLSVTNLEDLKR	DAGLB	496	Q8NCG7
IRSVKRLQLLPESFI	FBXO7	271	Q9Y3I1
EAPRERLIELIRSAK	FRMPD3	106	Q5JV73
ANRPKRLLLVLVSAL	GPR32P1	251	Q8NGA4
NRTPSRLLKEIILVD	GALNT8	206	Q9NY28
PRRISAISVAERVAK	DHX57	601	Q6P158
LLKRLEAARPSAVLD	CTU1	251	Q7Z7A3
LFSKALPEVAARLAI	GUCY2F	66	P51841
PFLLRRVKAEVATEL	CHD1L	256	Q86WJ1
RALSAVPAVLLVLTL	CBLN4	6	Q9NTU7
PSVREQLALLEARKL	CC2D1B	531	Q5T0F9
ASPIQDAVLKRLSLL	GALNT17	56	Q6IS24
EKPRVAALIDRLIAF	CEMIP2	766	Q9UHN6
VLRAVDRAIPLVLVS	CPPED1	111	Q9BRF8
VREQLARTLALKPTS	ELMO3	471	Q96BJ8
PASSRLQELLAVLLR	BRF2	261	Q9HAW0
LTAEKLRSVVTPARV	LYPLA2	186	O95372
ARLSRLPLARVKALV	POLE4	36	Q9NR33
SALPRLTEAERRLLK	KLB	801	Q86Z14
AISSRIIKTPRRFIE	KMT2A	416	Q03164
LPSAKGREELLRISL	KATNA1	381	O75449
PRRKLISVDSRSVSL	IL21R	171	Q9HBE5
TIVTRFLKLVPDLLA	HEATR1	1636	Q9H583
LAALARVPLAESKLL	EVC	906	P57679
LRNEITRLPAIKALT	CAND2	621	O75155
TRLPAIKALTLVAVS	CAND2	626	O75155
TRTLALELAPKDIRV	DHRS2	196	Q13268
LAIRRATLKRSFTPV	GFM1	281	Q96RP9
RLLETSALPRKSIIE	EFCAB3	146	Q8N7B9
NSILDLFRTPAIRKV	SLC22A20P	326	A6NK97
LAVVLLKARLVPAAA	FAM171B	16	Q6P995
LKARLVPAAARAELS	FAM171B	21	Q6P995
RVLRKLEVISSSPVL	NUP210L	1721	Q5VU65
IPIERLASERAITVK	PKD1	2861	P98161
IERLFLRSPATKVII	NXPE1	461	Q8N323
RRTKRDIVDSLSALP	NXF2	461	Q9GZY0
KPVATALEDLRARLL	NRAC	126	Q8N912
AERRRSAPSLILDKA	ARHGAP20	41	Q9P2F6
TKRPLIDARVLSRVT	RTTN	791	Q86VV8
VRVDRVPLASKLVDL	TAF7	56	Q15545
TLRVAEPIDELKLAR	SPATA17	261	Q96L03
EALRLLRKATALPAR	XAB2	451	Q9HCS7
VIVALARDSLALARP	SORL1	116	Q92673
LLARRSKAEELGLPI	ACAA1	286	P09110
DRARASLVLKQVPVL	TAPBPL	56	Q9BX59
PDLDAKIREALVLRS	PLD5	361	Q8N7P1
PELASRLTRISAVLL	TCP11L2	361	Q8N4U5
VSERDIRALIPLAKA	TMEM132A	391	Q24JP5
KALAQRLLEVTASLP	SYNE3	456	Q6ZMZ3
AELLKTTNPLARRII	NHSL2	1196	Q5HYW2
LRRAVPLALALISVS	PSMD2	686	Q13200
LAVSRTSSPVRARKL	RASGRF2	731	O14827
RLEPLRALLEKVAAT	PRAMEF19	336	Q5SWL8
IGDSKLRVILPALSR	PRAMEF19	361	Q5SWL8
KALLSHRPREVTVSL	PIK3R6	596	Q5UE93
FIRLEPLRALLEKVA	PRAMEF22	336	A3QJZ6
PLRALLEKVAATLQT	PRAMEF22	341	A3QJZ6
LLPKLARVISRLADF	ADSL	131	P30566
PKLAALLRVFSTVVR	SMG1	396	Q96Q15
LPALTRRLTAIIEEA	EPPK1	3631	P58107
LPALTRRLTAIIEEA	EPPK1	4701	P58107
LPRSEKLRSLVLAGI	SGSM3	101	Q96HU1
KDVRDLPRAAVRILS	SLCO5A1	416	Q9H2Y9
ELVEPSSVALRSILR	RNF6	471	Q9Y252
PTDLTLQLLAVRRKS	SH3TC1	81	Q8TE82
AFSKLENPRRVSILL	WRN	271	Q14191
LNAVRSLVPDALERK	SRR	61	Q9GZT4
ILLRRKLTAPVAFSV	ABCC12	366	Q96J65
VLKLLQSSARELRPL	RPTOR	476	Q8N122
PFVARSLLEKLSRQI	RIPOR2	766	Q9Y4F9
PLEVIKTRLQSSRLA	SLC25A33	31	Q9BSK2
TLTLEVLNEARVRKP	TGM3	596	Q08188
PAALLAVVRFLKRVV	ADGRD2	426	Q7Z7M1
VALTKRADPAELRTI	SLC25A13	6	Q9UJS0
VLASRLVLPRASELK	CHSY1	21	Q86X52
RKRLLFPALVTLLIS	CLCN2	361	P51788
PARSLTLQEALEVRK	C10orf90	566	Q96M02
LDASDRFAKVRPLII	PGBD2	236	Q6P3X8
PRVRAEALRTLTKVL	PIK3R4	431	Q99570
NDPSLRDKVTRVVLL	RAPGEF2	321	Q9Y4G8
LLIIRPAATAVISLA	SLC7A11	131	Q9UPY5
LEAARATPRRSSIIK	PLCL1	66	Q15111
DLATLRELSKQRLIP	RND2	126	P52198
IKRVLLVELPAFLRS	TNFAIP2	386	Q03169
LRPEARTKAQILELL	ZNF197	71	O14709
PDILKAEISTTRLRV	WWC2	161	Q6AWC2
LLLRSVLPALQARAA	TEP1	916	Q99973
DADLLVPASVKVLRR	PHIP	1726	Q8WWQ0
DVATKRIFSALRVLP	RNF112	476	Q9ULX5
LPVLERLRAENKSAV	TAFAZZIN	216	Q16635
SEVAPIKALRTLRAL	SCN10A	1241	Q9Y5Y9
ILNSKLRDRIPFAVV	SEPTIN12	236	Q8IYM1
ATALLLLKRSRIPIF	SERPINE3	361	A8MV23
SQLKLRVDIAVPLRA	nan	176	Q6ZUG5
LVRLPRAFRLTKDSV	ZPBP	46	Q9BS86
NSPLTERLIRKAATV	TTC38	451	Q5R3I4
LATRNLLLASPRTIK	TNK1	246	Q13470
LRVALSSIQPRLDKL	ZBED9	1301	Q6R2W3
LSVPQALRRKAELEV	PIGG	451	Q5H8A4
NPSETVRLTARILAK	SMYD2	101	Q9NRG4
LIEKLLTRTPDIAQR	STK39	346	Q9UEW8
KDPLAALRVRDILSR	UBR4	436	Q5T4S7
EERRKLVIARLPSVS	TBCEL	271	Q5QJ74
RDKPRLLAALEVASA	ULK3	371	Q6PHR2
DAPLAVLRAFKVLRT	TTI1	921	O43156
RKIPAHRLVLSSVSD	KLHL1	221	Q9NR64
RVVRLIKISPALEDF	NALCN	481	Q8IZF0
KNRDTLPTDIVLLLR	MYO3A	846	Q8NEV4
DRSQLASVPKILREL	MYO7B	1946	Q6PIF6
LRTDAIPIRAAKAAR	NEB	1066	P20929