Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	PA	NAALADL1 RNF149	1.79e-03	19	62	2	PF02225
Domain	PA_domain	NAALADL1 RNF149	1.79e-03	19	62	2	IPR003137
Pathway	REACTOME_TNFR1_INDUCED_PROAPOPTOTIC_SIGNALING	IKBKE TBK1 USP21	5.15e-05	23	45	3	MM15177
Pathway	REACTOME_TNFR1_INDUCED_PROAPOPTOTIC_SIGNALING	IKBKE TBK1 USP21	6.66e-05	25	45	3	M27435
Pathway	WP_GENETIC_CAUSES_OF_PORTOSINUSOIDAL_VASCULAR_DISEASE	GTF2I DLL4 NOTCH4	2.19e-04	37	45	3	M45513
Pathway	KEGG_MEDICUS_REFERENCE_TLR4_IRF3_7_SIGNALING_PATHWAY	IKBKE TBK1	3.54e-04	9	45	2	M47598
Pathway	KEGG_MEDICUS_REFERENCE_TLR3_IRF3_SIGNALING_PATHWAY	IKBKE TBK1	3.54e-04	9	45	2	M47451
Pathway	WP_SARSCOV2_B117_VARIANT_ANTAGONISES_INNATE_IMMUNE_ACTIVATION	IKBKE TBK1	3.54e-04	9	45	2	M42581
Pathway	REACTOME_REGULATION_OF_TNFR1_SIGNALING	IKBKE TBK1 USP21	4.47e-04	47	45	3	MM15179
Pathway	REACTOME_REGULATION_OF_TBK1_IKK_MEDIATED_ACTIVATION_OF_IRF3_IRF7_UPON_TLR3_LIGATION	IKBKE TBK1	5.38e-04	11	45	2	M48241
Pathway	REACTOME_NOTCH4_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS	DLL4 NOTCH4	5.38e-04	11	45	2	M27882
Pathway	REACTOME_TNF_SIGNALING	IKBKE TBK1 USP21	7.49e-04	56	45	3	MM15453
Pathway	REACTOME_TICAM1_DEPENDENT_ACTIVATION_OF_IRF3_IRF7	IKBKE TBK1	7.60e-04	13	45	2	M27884
Pathway	KEGG_MEDICUS_REFERENCE_NOTCH_SIGNALING_PATHWAY	DLL4 NOTCH4	7.60e-04	13	45	2	M47423
Pathway	REACTOME_TNF_SIGNALING	IKBKE TBK1 USP21	7.88e-04	57	45	3	M27713
Pathway	REACTOME_REGULATION_OF_TBK1_IKK_IKBKE_MEDIATED_ACTIVATION_OF_IRF3_IRF7	IKBKE TBK1	8.85e-04	14	45	2	M48239
Pathway	REACTOME_NEGATIVE_REGULATORS_OF_DDX58_IFIH1_SIGNALING	IKBKE TBK1	8.85e-04	14	45	2	MM15642
Pathway	REACTOME_REGULATION_OF_TBK1_IKK_IKBKE_MEDIATED_ACTIVATION_OF_IRF3_IRF7	IKBKE TBK1	1.02e-03	15	45	2	MM17228
Pathway	REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY	IKBKE TBK1	1.02e-03	15	45	2	M953
Pathway	REACTOME_DEATH_RECEPTOR_SIGNALING	IKBKE TBK1 ARHGEF18 USP21	1.07e-03	142	45	4	MM15431
Pathway	KEGG_MEDICUS_VARIANT_NOTCH_OVEREXPRESSION_TO_NOTCH_SIGNALING_PATHWAY	DLL4 NOTCH4	1.16e-03	16	45	2	M47424
Pathway	REACTOME_DEATH_RECEPTOR_SIGNALING	IKBKE TBK1 ARHGEF18 USP21	1.44e-03	154	45	4	M27697
Pathway	REACTOME_ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_IKBKE	IKBKE TBK1	1.48e-03	18	45	2	M970
Pathway	KEGG_MEDICUS_REFERENCE_TLR3_IRF7_SIGNALING_PATHWAY	IKBKE TBK1	1.65e-03	19	45	2	M47450
Pathway	REACTOME_ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_IKBKE	IKBKE TBK1	1.65e-03	19	45	2	MM15644
Pathway	REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS	PCF11 WDR33	1.83e-03	20	45	2	M497
Pathway	REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS	PCF11 WDR33	1.83e-03	20	45	2	MM15469
Pathway	WP_STING_PATHWAY_IN_KAWASAKILIKE_DISEASE_AND_COVID19	IKBKE TBK1	2.01e-03	21	45	2	M40061
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	PCF11 ATXN2L KMT2D GTF2I SUGP2 CLASP1 YLPM1 ZNF318 LIMCH1 BCL9 SRRM2 CIC	1.86e-08	774	65	12	15302935
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	PCF11 KMT2D WDR33 RANBP3 YLPM1 BCL9 ARID1A CIC	3.87e-08	268	65	8	33640491
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FLNC KMT2D RTL6 GAREM2 SUGP2 SZT2 CASKIN1 WDFY3 BCL9 ARID1A CHPF C2CD2 CIC	1.11e-07	1105	65	13	35748872
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	NEFH ZNF219 PELP1 CLASP1 CASKIN1 TBK1 YLPM1 ARHGEF18 ZNF318 LIMCH1 WDFY3 BCL9	1.98e-07	963	65	12	28671696
Pubmed	Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.	KMT2D GTF2I BCL9 ARID1A CIC	5.06e-07	83	65	5	28794006
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	JCAD ATXN2L CLASP1 IKBKE CEP112 EXPH5 RANBP3 LIMCH1 GNAS SRRM2 CIC	5.32e-07	861	65	11	36931259
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	PCF11 ATXN2L FLNC GTF2I WDR33 YLPM1 ZNF318 SRRM2	7.98e-07	399	65	8	35987950
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	ATXN2L KMT2D GTF2I SUGP2 WDR33 RANBP3 YLPM1 ZNF318 ARID1A	8.31e-07	549	65	9	38280479
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	PCF11 SUGP2 WDR33 YLPM1 BCL9 NCOA5	1.13e-06	180	65	6	35198878
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	PCF11 ATXN2L GTF2I PELP1 SUGP2 WDR33 YLPM1 ZNF318 ARID1A SRRM2 CIC	1.45e-06	954	65	11	36373674
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	ATXN2L CLASP1 WDR33 TBK1 ZNF318 GNAS CLSPN ARID1A CIC	1.46e-06	588	65	9	38580884
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	PCF11 KMT2D WDR33 YLPM1 BCL9 ARID1A CIC NCOA5	2.19e-06	457	65	8	32344865
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	JCAD KMT2D ZNF219 TBX4 WDFY3 BCL9 CSMD2 ARID1A CIC	2.85e-06	638	65	9	31182584
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	ATXN2L FLNC GTF2I PELP1 SUGP2 YLPM1 ZNF318 ARID1A SRRM2	3.44e-06	653	65	9	22586326
Pubmed	Identification of TBK1 and IKKε, the non-canonical IκB kinases, as crucial pro-survival factors in HTLV-1-transformed T lymphocytes.	IKBKE TBK1	3.44e-06	2	65	2	27123832
Pubmed	Breast cancer stem cells: something out of notching?	DLL4 NOTCH4	3.44e-06	2	65	2	21045140
Pubmed	IKKε and TBK1 expression in gastric cancer.	IKBKE TBK1	3.44e-06	2	65	2	27145266
Pubmed	Inhibition of TBK1/IKKε Promotes Regeneration of Pancreatic β-cells.	IKBKE TBK1	3.44e-06	2	65	2	30349097
Pubmed	Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity.	IKBKE TBK1	3.44e-06	2	65	2	15367631
Pubmed	IKKε and TBK1 in diffuse large B-cell lymphoma: A possible mechanism of action of an IKKε/TBK1 inhibitor to repress NF-κB and IL-10 signalling.	IKBKE TBK1	3.44e-06	2	65	2	32858764
Pubmed	Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKε and Reveal Mechanisms for Selective Inhibition.	IKBKE TBK1	3.44e-06	2	65	2	30082428
Pubmed	Nuclear accumulation of cRel following C-terminal phosphorylation by TBK1/IKK epsilon.	IKBKE TBK1	3.44e-06	2	65	2	16888014
Pubmed	Increased IKKϵ protein stability ensures efficient type I interferon responses in conditions of TBK1 deficiency.	IKBKE TBK1	3.44e-06	2	65	2	36936901
Pubmed	Hepatitis C virus NS2 protease inhibits host cell antiviral response by inhibiting IKKε and TBK1 functions.	IKBKE TBK1	3.44e-06	2	65	2	23096996
Pubmed	The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection.	IKBKE TBK1	3.44e-06	2	65	2	15210742
Pubmed	Cutting edge: Role of TANK-binding kinase 1 and inducible IkappaB kinase in IFN responses against viruses in innate immune cells.	IKBKE TBK1	3.44e-06	2	65	2	17056502
Pubmed	Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation.	IKBKE TBK1	3.44e-06	2	65	2	22619329
Pubmed	The kinases IKBKE and TBK1 regulate MYC-dependent survival pathways through YB-1 in AML and are targets for therapy.	IKBKE TBK1	3.44e-06	2	65	2	30504235
Pubmed	Functionally distinct effects of the C-terminal regions of IKKε and TBK1 on type I IFN production.	IKBKE TBK1	3.44e-06	2	65	2	24722368
Pubmed	Are the IKKs and IKK-related kinases TBK1 and IKK-epsilon similarly activated?	IKBKE TBK1	3.44e-06	2	65	2	18353649
Pubmed	The non-canonical IκB kinases IKKε and TBK1 as potential targets for the development of novel therapeutic drugs.	IKBKE TBK1	3.44e-06	2	65	2	23157677
Pubmed	Crystal structure and mechanism of activation of TANK-binding kinase 1.	IKBKE TBK1	3.44e-06	2	65	2	23453971
Pubmed	Notch signaling in primary endothelial cells.	DLL4 NOTCH4	3.44e-06	2	65	2	12814948
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	ATXN2L KMT2D WDR33 RANBP3 YLPM1 ARID1A SRRM2	3.50e-06	341	65	7	32971831
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	PCF11 ATXN2L KMT2D GTF2I SUGP2 CLASP1 ZNF318 BCL9 ARID1A SRRM2 CIC	5.80e-06	1103	65	11	34189442
Pubmed	OTUD1 deubiquitinase regulates NF-κB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways.	FLNC IKBKE TBK1	5.91e-06	19	65	3	35941131
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	ATXN2L CLASP1 WDR33 YLPM1 RNF149 ARHGEF18 CLSPN PPP1R13L VAMP4	8.71e-06	733	65	9	34672954
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	ATXN2L PELP1 WDR33 BCL9 CIC	9.98e-06	152	65	5	38360978
Pubmed	Importance of Validating Antibodies and Small Compound Inhibitors Using Genetic Knockout Studies-T Cell Receptor-Induced CYLD Phosphorylation by IKKε/TBK1 as a Case Study.	IKBKE TBK1	1.03e-05	3	65	2	29755980
Pubmed	Very large G protein-coupled receptor 1 regulates myelin-associated glycoprotein via Gαs/Gαq-mediated protein kinases A/C.	GNAS ADGRV1	1.03e-05	3	65	2	24191038
Pubmed	ORF45 of Kaposi's sarcoma-associated herpesvirus inhibits phosphorylation of interferon regulatory factor 7 by IKKε and TBK1 as an alternative substrate.	IKBKE TBK1	1.03e-05	3	65	2	22787218
Pubmed	Viral suppression of innate immunity via spatial isolation of TBK1/IKKε from mitochondrial antiviral platform.	IKBKE TBK1	1.03e-05	3	65	2	24706939
Pubmed	HTLV-1 Tax protein recruitment into IKKε and TBK1 kinase complexes enhances IFN-I expression.	IKBKE TBK1	1.03e-05	3	65	2	25531185
Pubmed	Delta-like 4/Notch pathway is differentially regulated in benign and malignant thyroid tissues.	DLL4 NOTCH4	1.03e-05	3	65	2	22066479
Pubmed	Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK.	IKBKE TBK1	1.03e-05	3	65	2	17327220
Pubmed	Single-cell Sequencing Reveals Variants in ARID1A, GPRC5A and MLL2 Driving Self-renewal of Human Bladder Cancer Stem Cells.	KMT2D ARID1A	1.03e-05	3	65	2	27387124
Pubmed	TBK1 and IKKε act like an OFF switch to limit NLRP3 inflammasome pathway activation.	IKBKE TBK1	1.03e-05	3	65	2	34518217
Pubmed	SOCS3 Drives Proteasomal Degradation of TBK1 and Negatively Regulates Antiviral Innate Immunity.	IKBKE TBK1	1.03e-05	3	65	2	25939384
Pubmed	Promoter organization of the interferon-A genes differentially affects virus-induced expression and responsiveness to TBK1 and IKKepsilon.	IKBKE TBK1	1.03e-05	3	65	2	16380379
Pubmed	Phosphorylation of RAB7 by TBK1/IKKε Regulates Innate Immune Signaling in Triple-Negative Breast Cancer.	IKBKE TBK1	1.03e-05	3	65	2	31662325
Pubmed	Evasion of antiviral immunity through sequestering of TBK1/IKKε/IRF3 into viral inclusion bodies.	IKBKE TBK1	1.03e-05	3	65	2	24335286
Pubmed	The role of the vascular endothelial growth factor-Delta-like 4 ligand/Notch4-ephrin B2 cascade in tumor vessel remodeling and endothelial cell functions.	DLL4 NOTCH4	1.03e-05	3	65	2	16951162
Pubmed	Peroxiredoxin 1 Interacts with TBK1/IKKε and Negatively Regulates Pseudorabies Virus Propagation by Promoting Innate Immunity.	IKBKE TBK1	1.03e-05	3	65	2	34260286
Pubmed	IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2.	IKBKE TBK1	1.03e-05	3	65	2	11839743
Pubmed	The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice.	IKBKE TBK1	1.03e-05	3	65	2	32220666
Pubmed	A20 is a negative regulator of IFN regulatory factor 3 signaling.	IKBKE TBK1	1.03e-05	3	65	2	15661910
Pubmed	The vascular delta-like ligand-4 (DLL4)-Notch4 signaling correlates with angiogenesis in primary glioblastoma: an immunohistochemical study.	DLL4 NOTCH4	1.03e-05	3	65	2	26472724
Pubmed	Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1.	IKBKE TBK1	1.03e-05	3	65	2	24368730
Pubmed	Human transcription factor protein interaction networks.	PCF11 KMT2D GTF2I SUGP2 WDR33 YLPM1 HIC2 ZNF318 BCL9 ARID1A SRRM2 CIC	1.18e-05	1429	65	12	35140242
Pubmed	Functional proteomics mapping of a human signaling pathway.	FLNC KMT2D TBX4 PELP1 EXPH5 YLPM1 PPP1R13L CHPF	1.43e-05	591	65	8	15231748
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	PCF11 GTF2I SUGP2 RANBP3 YLPM1 ZNF318	1.52e-05	283	65	6	30585729
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	JCAD RANBP3 YLPM1 ARHGEF18 BCL9 CLSPN CIC	1.58e-05	430	65	7	35044719
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	ZNF219 GTF2I PELP1 SUGP2 YLPM1 ARID1A SRRM2 NCOA5	1.69e-05	605	65	8	28977666
Pubmed	Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.	PCF11 KMT2D GTF2I SRRM2 NCOA5	1.71e-05	170	65	5	16159877
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	PCF11 ATXN2L GTF2I PELP1 YLPM1 ZNF318 ARID1A	1.83e-05	440	65	7	34244565
Pubmed	Cancer gene mutation frequencies for the U.S. population.	KMT2D ARID1A	2.06e-05	4	65	2	34645806
Pubmed	Mitochondria-associated membrane collapse impairs TBK1-mediated proteostatic stress response in ALS.	IKBKE TBK1	2.06e-05	4	65	2	37967220
Pubmed	Whirlin complexes with p55 at the stereocilia tip during hair cell development.	GNAS MYO15A	2.06e-05	4	65	2	16829577
Pubmed	Genetically programmed alternative splicing of NEMO mediates an autoinflammatory disease phenotype.	IKBKE TBK1	2.06e-05	4	65	2	35289316
Pubmed	TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells.	IKBKE TBK1	2.06e-05	4	65	2	32268090
Pubmed	SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways.	IKBKE TBK1	2.06e-05	4	65	2	16281057
Pubmed	Suppression of innate antiviral response by severe acute respiratory syndrome coronavirus M protein is mediated through the first transmembrane domain.	IKBKE TBK1	2.06e-05	4	65	2	24509444
Pubmed	Beyond conventional chemotherapy: Emerging molecular targeted and immunotherapy strategies in urothelial carcinoma.	KMT2D ARID1A	2.06e-05	4	65	2	26138514
Pubmed	TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation.	IKBKE TBK1	2.06e-05	4	65	2	24562310
Pubmed	Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1.	IKBKE TBK1	2.06e-05	4	65	2	19153231
Pubmed	Notch1 and Notch4 core binding domain peptibodies exhibit distinct ligand-binding and anti-angiogenic properties.	DLL4 NOTCH4	2.06e-05	4	65	2	36376768
Pubmed	IKKε and TBK1 prevent RIPK1 dependent and independent inflammation.	IKBKE TBK1	2.06e-05	4	65	2	38167258
Pubmed	Estrogen receptor alpha inhibits RLR-mediated immune response via ubiquitinating TRAF3.	IKBKE TBK1	2.06e-05	4	65	2	26186972
Pubmed	TTLL12 Inhibits the Activation of Cellular Antiviral Signaling through Interaction with VISA/MAVS.	IKBKE TBK1	2.06e-05	4	65	2	28011935
Pubmed	A CRM1-dependent nuclear export pathway is involved in the regulation of IRF-5 subcellular localization.	IKBKE TBK1	2.06e-05	4	65	2	15556946
Pubmed	The E3 Ubiquitin Ligase TBK1 Mediates the Degradation of Multiple Picornavirus VP3 Proteins by Phosphorylation and Ubiquitination.	IKBKE TBK1	2.06e-05	4	65	2	31534043
Pubmed	Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD.	IKBKE TBK1	2.06e-05	4	65	2	18467330
Pubmed	Association of a Network of Interferon-Stimulated Genes with a Locus Encoding a Negative Regulator of Non-conventional IKK Kinases and IFNB1.	IKBKE TBK1	2.06e-05	4	65	2	27705791
Pubmed	Functional dissection of the TBK1 molecular network.	IKBKE TBK1	2.06e-05	4	65	2	21931631
Pubmed	RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex.	ATXN2L ARID1A SRRM2	2.20e-05	29	65	3	36800290
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	KMT2D ZNF219 GTF2I PELP1 WDR33 YLPM1 ZNF318 ARID1A SRRM2 CIC NCOA5	2.56e-05	1294	65	11	30804502
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	PCF11 FLNC SUGP2 CLASP1 WDR33 YLPM1 HIC2 ARID1A SRRM2 NCOA5	3.09e-05	1082	65	10	38697112
Pubmed	Expression patterns of Notch receptors and their ligands Jagged and Delta in human placenta.	DLL4 NOTCH4	3.43e-05	5	65	2	21726900
Pubmed	TRAF6-dependent Act1 phosphorylation by the IκB kinase-related kinases suppresses interleukin-17-induced NF-κB activation.	IKBKE TBK1	3.43e-05	5	65	2	22851696
Pubmed	IκB kinase ε-dependent phosphorylation and degradation of X-linked inhibitor of apoptosis sensitizes cells to virus-induced apoptosis.	IKBKE TBK1	3.43e-05	5	65	2	22072751
Pubmed	The Ret finger protein inhibits signaling mediated by the noncanonical and canonical IkappaB kinase family members.	IKBKE TBK1	3.43e-05	5	65	2	16393995
Pubmed	IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.	IKBKE TBK1	3.43e-05	5	65	2	21464307
Pubmed	Selective autophagy controls the stability of TBK1 via NEDD4 to balance host defense.	IKBKE TBK1	3.43e-05	5	65	2	34257412
Pubmed	Intraovarian regulation of gonadotropin-dependent folliculogenesis depends on notch receptor signaling pathways not involving Delta-like ligand 4 (Dll4).	DLL4 NOTCH4	3.43e-05	5	65	2	23675950
Pubmed	RING finger protein 11 targets TBK1/IKKi kinases to inhibit antiviral signaling.	IKBKE TBK1	3.43e-05	5	65	2	23308279
Pubmed	A novel IRAK1-IKKε signaling axis limits the activation of TAK1-IKKβ downstream of TLR3.	IKBKE TBK1	3.43e-05	5	65	2	23396947
Pubmed	Involvement of the IkappaB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation.	IKBKE TBK1	3.43e-05	5	65	2	17015689
Pubmed	The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways.	IKBKE TBK1	3.43e-05	5	65	2	17468758
Pubmed	Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system.	IKBKE TBK1	3.43e-05	5	65	2	22007846
Pubmed	The SARS-CoV-2 papain-like protease suppresses type I interferon responses by deubiquitinating STING.	IKBKE TBK1	3.43e-05	5	65	2	37130168
Interaction	AR interactions	PCF11 KMT2D GTF2I PELP1 SUGP2 WDR33 EXPH5 RANBP3 YLPM1 ZNF318 LIMCH1 GNAS BCL9 ARID1A CIC	2.88e-07	992	63	15	int:AR
Interaction	ALG13 interactions	PCF11 KMT2D WDR33 WDFY3 BCL9 ARID1A NCOA5	1.64e-06	183	63	7	int:ALG13
Interaction	TOP3B interactions	FLNC KMT2D RTL6 GTF2I GAREM2 PELP1 SUGP2 SZT2 CASKIN1 WDFY3 GNAS BCL9 ARID1A CHPF ADAMTSL4 C2CD2 CIC	1.72e-06	1470	63	17	int:TOP3B
Interaction	GATA3 interactions	PCF11 KMT2D SUGP2 BCL9 ARID1A CIC USP21	1.89e-06	187	63	7	int:GATA3
Interaction	B9D2 interactions	SUGP2 WDR33 YLPM1 ZNF318 NCOA5	3.24e-06	73	63	5	int:B9D2
Interaction	SP7 interactions	PCF11 KMT2D WDR33 YLPM1 ZNF318 BCL9 ARID1A CIC	4.61e-06	304	63	8	int:SP7
Interaction	CPSF6 interactions	PCF11 ATXN2L SUGP2 WDR33 TBK1 YLPM1 ZNF318 SRRM2 USP21 NCOA5	4.97e-06	526	63	10	int:CPSF6
Interaction	TERF2IP interactions	PCF11 GTF2I SUGP2 WDR33 ZNF318 WDFY3 CLSPN ARID1A SRRM2 CIC	7.59e-06	552	63	10	int:TERF2IP
Interaction	GATA1 interactions	PCF11 KMT2D SUGP2 ZNF318 BCL9 ARID1A	1.56e-05	171	63	6	int:GATA1
Interaction	YAP1 interactions	JCAD ATXN2L KMT2D GTF2I IKBKE WDR33 RANBP3 TBK1 YLPM1 ZNF318 GNAS ARID1A SRRM2	2.77e-05	1095	63	13	int:YAP1
Interaction	YWHAH interactions	JCAD ATXN2L RNF5 CLASP1 IKBKE CEP112 EXPH5 RANBP3 TBK1 LIMCH1 SRRM2 CIC USP21	2.96e-05	1102	63	13	int:YWHAH
Interaction	NUP35 interactions	PCF11 KMT2D WDR33 YLPM1 BCL9 ARID1A CIC NCOA5	5.06e-05	424	63	8	int:NUP35
Interaction	SMG7 interactions	PCF11 KMT2D YLPM1 ZNF318 BCL9 CLSPN ARID1A	6.03e-05	319	63	7	int:SMG7
Interaction	GCM1 interactions	KMT2D BCL9 ARID1A CIC	6.08e-05	68	63	4	int:GCM1
Interaction	SOX15 interactions	KMT2D BCL9 ARID1A SRRM2 CIC	7.92e-05	141	63	5	int:SOX15
Interaction	LRRC10B interactions	IKBKE TBK1	9.56e-05	5	63	2	int:LRRC10B
Interaction	DHX40 interactions	PCF11 WDR33 YLPM1 ZNF318 CLSPN NCOA5	1.26e-04	249	63	6	int:DHX40
Interaction	DLL4 interactions	DLL4 NOTCH4	1.43e-04	6	63	2	int:DLL4
Interaction	LHX4 interactions	KMT2D BCL9 ARID1A ADAMTSL4 CIC	1.71e-04	166	63	5	int:LHX4
Interaction	SOX10 interactions	KMT2D BCL9 ARID1A CIC	1.97e-04	92	63	4	int:SOX10
Interaction	SOX17 interactions	KMT2D BCL9 ARID1A CIC	2.23e-04	95	63	4	int:SOX17
Interaction	SOX9 interactions	KMT2D BCL9 ARID1A CIC	2.42e-04	97	63	4	int:SOX9
Interaction	SMC5 interactions	PCF11 ATXN2L GTF2I PELP1 SUGP2 WDR33 YLPM1 ZNF318 ARID1A SRRM2 CIC	2.44e-04	1000	63	11	int:SMC5
Interaction	FMR1 interactions	ATXN2L ZNF219 CLASP1 CASKIN1 TBK1 ARHGEF18 WDFY3 BCL9	2.54e-04	536	63	8	int:FMR1
Interaction	YBEY interactions	L3MBTL1 GNAS ATPAF1 CHST8	2.61e-04	99	63	4	int:YBEY
Interaction	RBBP5 interactions	KMT2D PELP1 WDR33 TBK1 ARID1A SRRM2	2.72e-04	287	63	6	int:RBBP5
Interaction	SUPT5H interactions	PCF11 KMT2D WDR33 RANBP3 ARID1A CIC NCOA5	2.76e-04	408	63	7	int:SUPT5H
Interaction	MEN1 interactions	PCF11 ATXN2L KMT2D GTF2I PELP1 SUGP2 WDR33 RANBP3 YLPM1 ARID1A SRRM2	3.12e-04	1029	63	11	int:MEN1
Interaction	MAPK3 interactions	PCF11 ZNF219 GTF2I IER3 CLSPN CIC USP21	3.34e-04	421	63	7	int:MAPK3
Coexpression	GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN	ATXN2L KMT2D SUGP2 SZT2 RANBP3 SRRM2 CIC USP21	1.87e-06	338	65	8	M17094
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BCL6B JCAD DLL4 SLC38A5 HAPLN3 NOTCH4 ADM5	1.67e-08	199	65	7	1295f34a350bf48987e2fad411aaac3630efd3f1
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BCL6B JCAD DLL4 SLC38A5 NOTCH4 ADM5	3.86e-07	193	65	6	3f8280ef849d95b2fcea5e6824b95a07febc96d0
ToppCell	10x5'v1-week_14-16-Endothelial-stroma-proliferating_EC\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	BCL6B JCAD DLL4 HAPLN3 FZD10 NOTCH4	3.98e-07	194	65	6	8a4be91414a2e69dd410aa75791f16008204c9a1
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BCL6B JCAD DLL4 SLC38A5 NOTCH4 ADM5	4.35e-07	197	65	6	62c0a90869431e582bb7bb329e0b0cc59123d3d1
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BCL6B JCAD DLL4 SLC38A5 NOTCH4 ADM5	4.35e-07	197	65	6	a312d9cf4ced949307eb9620be4eed926300b892
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BCL6B JCAD DLL4 SLC38A5 NOTCH4 ADM5	4.35e-07	197	65	6	9e948b2e0f7e426f1e6f95bbbf4282fbddc2b99d
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BCL6B JCAD DLL4 SLC38A5 NOTCH4 ADM5	4.35e-07	197	65	6	16f0eb047df9d702518f82ee99c6e7dc1350b2fb
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-A\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BCL6B JCAD DLL4 SLC38A5 HAPLN3 NOTCH4	4.48e-07	198	65	6	72e8b9cccb7b0a2ea9d415218fff4fa2f09728f4
ToppCell	metastatic_Brain-Endothelial_cells\|metastatic_Brain / Location, Cell class and cell subclass	BCL6B JCAD DLL4 SLC38A5 NOTCH4 ADM5	4.48e-07	198	65	6	97ef7946ef11ac93318c1dd46b548dc01e5a6aba
ToppCell	metastatic_Brain-Endothelial_cells-Tumor_ECs\|metastatic_Brain / Location, Cell class and cell subclass	BCL6B JCAD DLL4 SLC38A5 NOTCH4 ADM5	4.48e-07	198	65	6	5e274f29cc796dae7d64d6035e904816c25f9914
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BCL6B JCAD DLL4 SLC38A5 NOTCH4 ADM5	4.62e-07	199	65	6	236b1417ed0875e98c6ec1ec714003bfce438d65
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BCL6B JCAD DLL4 SLC38A5 NOTCH4 ADM5	4.62e-07	199	65	6	c5c12c8288fe868322bae9d691b91fee953ceb3e
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BCL6B JCAD DLL4 SLC38A5 NOTCH4 ADM5	4.62e-07	199	65	6	0602e2b2aa56d106da63bd342a38bef437b4d496
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BCL6B JCAD DLL4 SLC38A5 NOTCH4 ADM5	4.75e-07	200	65	6	86ec951234015ced7126b016199e5869a0f22478
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BCL6B JCAD DLL4 SLC38A5 NOTCH4 ADM5	4.75e-07	200	65	6	c239e6f5d23caa9a59b83e9b352b2d6a691dcb28
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BCL6B JCAD DLL4 SLC38A5 NOTCH4 ADM5	4.75e-07	200	65	6	061ba851f941c616ddb462512e826c412881c3ce
ToppCell	368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)\|368C / Donor, Lineage, Cell class and subclass (all cells)	BCL6B JCAD DLL4 EXPH5 NOTCH4	4.45e-06	166	65	5	30a991fc3275b571d53bd0976df4789e5d40b01d
ToppCell	368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	BCL6B JCAD DLL4 EXPH5 NOTCH4	4.45e-06	166	65	5	76b4cd32698900797ec009f17e50ea7ae36b85f4
ToppCell	356C-Endothelial_cells-Endothelial-B_(Artery)\|356C / Donor, Lineage, Cell class and subclass (all cells)	BCL6B JCAD DLL4 NOTCH4 ADM5	4.85e-06	169	65	5	605cc2638271803cf1d972ab3fa8f13f89666376
ToppCell	356C-Endothelial_cells-Endothelial-B_(Artery)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	BCL6B JCAD DLL4 NOTCH4 ADM5	4.85e-06	169	65	5	337be3bf485b54afad86e256cb0c4c1d0c2a9a2a
ToppCell	10x3'2.3-week_14-16-Endothelial-stroma-proliferating_EC\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	BCL6B JCAD DLL4 HAPLN3 NOTCH4	6.96e-06	182	65	5	997d37ca2af661c92a56add888762724dfccc890
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	BCL6B JCAD DLL4 NOTCH4 ADM5	7.14e-06	183	65	5	ce8be9418b473ea94ec806edc7a2078cc30c1703
ToppCell	5'-GW_trimst-2-LymphNode-Endothelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BCL6B JCAD HAPLN3 NOTCH4 ADM5	7.33e-06	184	65	5	df2d42e1eae29fa0a1ed9e389c95b38952b46892
ToppCell	3'-Child09-12-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	JCAD DLL4 LIMCH1 NOTCH4 ADM5	7.33e-06	184	65	5	842473fa415575441b595073a994b6d621169776
ToppCell	5'-GW_trimst-2-LymphNode-Endothelial-blood_vessel_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BCL6B JCAD HAPLN3 NOTCH4 ADM5	7.33e-06	184	65	5	1ace70f12b417185bdd46042833f72b3b6815966
ToppCell	normal_Lung-Endothelial_cells-Tumor_ECs\|normal_Lung / Location, Cell class and cell subclass	BCL6B JCAD DLL4 NOTCH4 ADM5	7.33e-06	184	65	5	7ee98acda030366ac6cf3890a6d93fd0426712ed
ToppCell	COPD-Endothelial-VE_Capillary_A\|COPD / Disease state, Lineage and Cell class	BCL6B JCAD DLL4 EXPH5 NOTCH4	7.33e-06	184	65	5	5f4f7775d488ececf086c71441defecbee9d8a9c
ToppCell	droplet-Fat-Scat-21m-Endothelial-Cd36+\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BCL6B JCAD DLL4 LIMCH1 NOTCH4	8.14e-06	188	65	5	8671fdbc4138e6f9559920779c98628ed80f0da3
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BCL6B JCAD SLC38A5 NOTCH4 ADM5	8.35e-06	189	65	5	f44ddb6cdbb406b0528a9b0ba3811183ab6d1fc6
ToppCell	3'-GW_trimst-1-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BCL6B JCAD DLL4 LIMCH1 NOTCH4	8.35e-06	189	65	5	1d660bceee449aebf12fc9af4c74af246837b27a
ToppCell	droplet-Fat-Scat-21m-Endothelial-endothelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BCL6B JCAD DLL4 LIMCH1 NOTCH4	8.57e-06	190	65	5	d3e46cf800a07ca9b01c78192962d223b9785d05
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BCL6B JCAD DLL4 SLC38A5 NOTCH4	8.57e-06	190	65	5	06bfb62b94b0faf467ef93d5bc5d08924c770098
ToppCell	droplet-Fat-Scat-21m-Endothelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BCL6B JCAD DLL4 LIMCH1 NOTCH4	8.57e-06	190	65	5	dd89ef1ecea20b2f6fbdc6cea4ca41b28b3ed822
ToppCell	human_hepatoblastoma-Endothelial_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	BCL6B JCAD DLL4 LIMCH1 NOTCH4	8.57e-06	190	65	5	8d6ef93d69e96cd6921816d152bea3b0710cf147
ToppCell	facs-Heart-LA-3m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BCL6B JCAD DLL4 LIMCH1 NOTCH4	8.79e-06	191	65	5	a15f0fb4bd7dd77ef5f931b6fc9d68697deec1d1
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	BCL6B JCAD DLL4 NOTCH4 ADM5	8.79e-06	191	65	5	04c7aa2e39fdd08ca24c10d43b29a5e41a73b9e0
ToppCell	facs-Heart-LA-3m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BCL6B JCAD DLL4 LIMCH1 NOTCH4	8.79e-06	191	65	5	827be47d3574c6c5b021c6f1c1670834344f10cb
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	BCL6B JCAD DLL4 NOTCH4 ADM5	8.79e-06	191	65	5	db8dd6bbba803585bdd6a55d5c403d383f2e9acf
ToppCell	facs-Lung-EPCAM-18m-Mesenchymal-Alveolar_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBX4 SLC38A5 LIMCH1 CHPF CHST8	9.24e-06	193	65	5	fa45042d30f9cfeed10e23270a78f18551219cfa
ToppCell	PCW_05-06-Endothelial-Endothelial_mature-endo_capillary_(2)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	BCL6B JCAD DLL4 NOTCH4 ADM5	9.24e-06	193	65	5	4f38aae346ea3b4258744e9dc1e5aeb4fea13d06
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	BCL6B JCAD DLL4 NOTCH4 ADM5	9.24e-06	193	65	5	3a9fe4e709c09ec787c71bdd6b58a71c419896de
ToppCell	facs-Lung-EPCAM-18m-Mesenchymal-fibroblast_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBX4 SLC38A5 LIMCH1 CHPF CHST8	9.24e-06	193	65	5	ab511ea9e09216a965b3ae5a94f8c3c1ae33d944
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BCL6B JCAD DLL4 SLC38A5 NOTCH4	9.48e-06	194	65	5	ea5e1bc8d9e27cabfe1fb833ca47ec0893593b12
ToppCell	facs-Heart-LA-3m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BCL6B JCAD DLL4 LIMCH1 NOTCH4	9.48e-06	194	65	5	33cc4f1d716cb71d54cdedbe9bbdc0d7b17c4777
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BCL6B JCAD DLL4 SLC38A5 NOTCH4	9.48e-06	194	65	5	cceb7c88492bb6cd531e1c2651638da1ddf30931
ToppCell	PCW_10-12-Endothelial-Endothelial_immature-endo_immature_arterial1_(12)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	BCL6B JCAD DLL4 NOTCH4 ADM5	9.72e-06	195	65	5	3826bfafe85f8aa9a508202ceb2b02e81b090498
ToppCell	3'-Child09-12-SmallIntestine-Endothelial-blood_vessel_EC\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BCL6B JCAD LIMCH1 NOTCH4 ADM5	9.96e-06	196	65	5	a0ba408b802fa6d6e42e6d234b6879fdb1583f81
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BCL6B JCAD SLC38A5 NOTCH4 ADM5	9.96e-06	196	65	5	ed818de15f84f7f28bd06fd69d7876710da232a0
ToppCell	Tracheal-10x3prime_v2-Stromal-Fibroblastic-Fibro_immune_recruiting\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ABHD4 NAALADL1 CCBE1 ADAMTSL4 USP21	1.02e-05	197	65	5	4edf043e8f586fd375f56485841fe992a18bf853
ToppCell	3'-Child09-12-SmallIntestine-Endothelial\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BCL6B JCAD LIMCH1 NOTCH4 ADM5	1.02e-05	197	65	5	86a02fd7b4762b3278e5e60b5483b5fc1206e597
ToppCell	3'-GW_trimst-1-LargeIntestine-Endothelial\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BCL6B JCAD DLL4 HAPLN3 NOTCH4	1.02e-05	197	65	5	4623cce5eca0c26c8103950e9874b40918226aa5
ToppCell	356C-Endothelial_cells\|356C / Donor, Lineage, Cell class and subclass (all cells)	BCL6B JCAD DLL4 NOTCH4 ADM5	1.02e-05	197	65	5	f20eda534b2b28986790b28ce150ca3ba067593a
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BCL6B JCAD DLL4 HAPLN3 NOTCH4	1.02e-05	197	65	5	dfc052a447c3b32235fcaffdf06c4e0941723d19
ToppCell	H1299-infected-SARSCoV2\|infected / Cell line, Condition and Strain	NEFH PELP1 CLSPN SRRM2 KNG1	1.02e-05	197	65	5	0fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-A\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BCL6B JCAD DLL4 SLC38A5 NOTCH4	1.02e-05	197	65	5	9244f087ba4b60fdc81d54ce91860de715b3e12c
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BCL6B JCAD DLL4 SLC38A5 NOTCH4	1.05e-05	198	65	5	218f33e068eb126458ec33176de3cfa6fc06ddf0
ToppCell	(6)_Endothelial_cells\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	BCL6B JCAD DLL4 NOTCH4 ADM5	1.05e-05	198	65	5	f38f49d532fa6211f57e36ee494478bdd3f4f89c
ToppCell	tumor_Lung-Endothelial_cells-Tumor_ECs\|tumor_Lung / Location, Cell class and cell subclass	BCL6B JCAD DLL4 NOTCH4 ADM5	1.05e-05	198	65	5	5228c4bf2513186140c2c4eaa67a268c732bdc84
ToppCell	3'-Pediatric_IBD-SmallIntestine-Endothelial-blood_vessel_EC\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BCL6B JCAD LIMCH1 NOTCH4 ADM5	1.05e-05	198	65	5	5b86dc00acf8ac2ede008f5d79c09996485bf250
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BCL6B JCAD DLL4 SLC38A5 NOTCH4	1.05e-05	198	65	5	e1fa02184ce93c4f8aa5cf04b70949cd4c425ff0
ToppCell	5'-Adult-Distal_Rectal-Endothelial-blood_vessel_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	JCAD DLL4 HAPLN3 LIMCH1 NOTCH4	1.05e-05	198	65	5	d1f54ed3ef5e05ebda7da999e172d168dc6802cd
ToppCell	5'-Adult-Distal_Rectal-Endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	JCAD DLL4 HAPLN3 LIMCH1 NOTCH4	1.05e-05	198	65	5	8d6b0b9da7c1e64155cbcbb04ad38d129a29030c
ToppCell	3'-Child04-06-SmallIntestine-Endothelial-blood_vessel_EC\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BCL6B JCAD DLL4 LIMCH1 NOTCH4	1.05e-05	198	65	5	99be7a7a84199dac598e993a5a0144d9030f13ce
ToppCell	5'-Adult-Appendix-Endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BCL6B JCAD CEP112 LIMCH1 NOTCH4	1.05e-05	198	65	5	90e85fe7a0ab376a41666dfff6c0e95b7f1c9475
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BCL6B JCAD DLL4 SLC38A5 NOTCH4	1.05e-05	198	65	5	7cddd474416651088a4e08edfc0ac420ff10a5fe
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BCL6B JCAD DLL4 LIMCH1 NOTCH4	1.05e-05	198	65	5	f7a957e8f09d54a55a5dbecfaa9cdf01e6fd543d
ToppCell	(6)_Endothelial-E\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	BCL6B JCAD DLL4 NOTCH4 ADM5	1.05e-05	198	65	5	a5e1b321376caf262ea48904d31afd1b8e9d3be2
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_immature\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BCL6B JCAD DLL4 SLC38A5 NOTCH4	1.07e-05	199	65	5	9c40b3ee39860e9d8edafd007daec11abdd95435
ToppCell	343B-Endothelial_cells-Endothelial-E-\|343B / Donor, Lineage, Cell class and subclass (all cells)	BCL6B JCAD DLL4 NOTCH4 ADM5	1.07e-05	199	65	5	bff61a784ef8bc040f5c7baabccaf7a7cddd5a31
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BCL6B JCAD DLL4 NOTCH4 ADM5	1.07e-05	199	65	5	b15304d3d3f6c254969b54a61bee3d9f368840b2
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BCL6B JCAD DLL4 SLC38A5 NOTCH4	1.07e-05	199	65	5	d95d78b2ebc9a20532466e4d4be579b4faf6776f
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BCL6B JCAD DLL4 SLC38A5 NOTCH4	1.07e-05	199	65	5	cdcfca94baba66e213cc3ffb0cfb4c75d6ab44ec
ToppCell	3'-Child04-06-SmallIntestine-Endothelial-blood_vessel_EC-arterial_capillary\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BCL6B JCAD DLL4 LIMCH1 NOTCH4	1.07e-05	199	65	5	57709dc893da8d9333830b8277a6d92e25aa8bc0
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BCL6B JCAD DLL4 SLC38A5 NOTCH4	1.07e-05	199	65	5	72b34bce8157abe389e95cd3ed8ba578dce0cbf6
ToppCell	3'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BCL6B JCAD DLL4 HAPLN3 NOTCH4	1.07e-05	199	65	5	0d63da0afa93741c37609d879941de202d9ac86c
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BCL6B JCAD DLL4 SLC38A5 NOTCH4	1.07e-05	199	65	5	463ba77dc4c85eebb343f29a42c7ac889b0497c9
ToppCell	343B-Endothelial_cells-Endothelial-E\|343B / Donor, Lineage, Cell class and subclass (all cells)	BCL6B JCAD DLL4 NOTCH4 ADM5	1.07e-05	199	65	5	3cb1d9d9de64ed0a56c4f8d5e2fa02a13a73d8ac
ToppCell	proximal-Endothelial\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	BCL6B JCAD DLL4 HAPLN3 ADM5	1.10e-05	200	65	5	970dac1b11ae8f4adb26634717064289967b4bde
ToppCell	proximal-3-Endothelial\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	BCL6B JCAD DLL4 HAPLN3 ADM5	1.10e-05	200	65	5	90c36cfb9632a3bdc9a335b2193f6b08aba35208
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-venous_capillary\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BCL6B JCAD DLL4 LIMCH1 NOTCH4	1.10e-05	200	65	5	ae6cc5462a8a254682793fb8cc348b9721c729bf
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BCL6B JCAD DLL4 LIMCH1 NOTCH4	1.10e-05	200	65	5	9e44da8aaac239ed69d674dcd53800c5eaf397cb
ToppCell	distal-Endothelial-Capillary_Intermediate_1-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	BCL6B JCAD DLL4 EXPH5 NOTCH4	1.10e-05	200	65	5	43bc48413b100a06f8edd9acd812296788fcbf5b
ToppCell	distal-Endothelial-Capillary_Intermediate_1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	BCL6B JCAD DLL4 EXPH5 NOTCH4	1.10e-05	200	65	5	4d6714d48738cdee7d535923f6dd2431e5304741
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_STALK\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	BCL6B TBX4 DLL4 SLC38A5	5.70e-05	143	65	4	35d3652680c4dddd293301595d813161c66e5673
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(NPW+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EXPH5 CASKIN1 ADGRV1 CHST8	7.79e-05	155	65	4	498e52e2364ff44d3c0c707ba22468217031f5bd
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_STALK\|Thalamus / BrainAtlas - Mouse McCarroll V32	BCL6B TBX4 DLL4 NOTCH4	7.79e-05	155	65	4	fe6c4aba0e98cda84bf178aeac2e9fa834477f22
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	BCL6B JCAD FZD10 NOTCH4	7.99e-05	156	65	4	f894fac4e44a23718b20ad80c9677bf4f2118002
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell_prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	JCAD DLL4 CLSPN CHST8	8.81e-05	160	65	4	830e3ef8c9708d25872c3052a0b2682fa9372111
ToppCell	TCGA-Adrenal-Primary_Tumor-Pheochromocytoma-Pheochromocytoma-3\|TCGA-Adrenal / Sample_Type by Project: Shred V9	BCL6B DLL4 FZD10 NOTCH4	9.02e-05	161	65	4	52239a887799362256ecd7e740b716b88ed59a62
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_artery-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	BCL6B JCAD DLL4 NOTCH4	9.24e-05	162	65	4	25bb1b9709f960fdf90faff56e874f52a8f5d17e
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla-lymphatic_endothelial_cell_of_renal_medulla\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	BCL6B RTL6 GAREM2 CHST8	9.69e-05	164	65	4	a784f47f67a5eda84d58ad7d9400e3978edbb487
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	BCL6B RTL6 GAREM2 CHST8	9.69e-05	164	65	4	1a1795969673232191425dde84ab24ee6a98143f
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	BCL6B RTL6 GAREM2 CHST8	9.69e-05	164	65	4	8f074940afdbda88a4b697a7ddc687e09a4b818b
ToppCell	E17.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	JCAD SLC38A5 FZD10 LIMCH1	1.11e-04	170	65	4	7fa022471e14ac8a3bc147c793368a4d56a8e591
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_artery-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	BCL6B JCAD DLL4 NOTCH4	1.16e-04	172	65	4	de9b11ab109d04937186c09772cec9105a935f95
ToppCell	Endothelial-A-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	BCL6B JCAD NOTCH4 ADM5	1.16e-04	172	65	4	a3201773a25832e92dd113fad165f1ecd37f5e91
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-arterial_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	BCL6B JCAD DLL4 NOTCH4	1.19e-04	173	65	4	3a9e9a09b3eeb37cbe56d650e112a8398879477f
ToppCell	droplet-Kidney-nan-18m-Endothelial-kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DLL4 LIMCH1 NOTCH4 CHST8	1.27e-04	176	65	4	5386386619cf173939d3c117b20e6f27ab397993
ToppCell	droplet-Kidney-nan-18m-Endothelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DLL4 LIMCH1 NOTCH4 CHST8	1.27e-04	176	65	4	820edade963768e4bfd86b554da4cd7100567ac8
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	JCAD NAALADL1 DLL4 NOTCH4	1.27e-04	176	65	4	64e426f5e84884ce2c29acf6f4b958962a63927f
Drug	Etofenamate [30544-47-9]; Up 200; 10.8uM; MCF7; HT_HG-U133A	ATXN2L L3MBTL1 SZT2 CEP112 LIMCH1 SRRM2 CIC	1.25e-06	192	65	7	4108_UP
Drug	Naringenine [480-41-1]; Up 200; 14.6uM; MCF7; HT_HG-U133A	SZT2 IKBKE ARHGEF18 HIC2 CHPF SRRM2 CIC	1.39e-06	195	65	7	3278_UP
Drug	trifluoperazine dihydrochloride; Down 200; 10uM; MCF7; HT_HG-U133A	GTF2I SUGP2 CLASP1 RANBP3 ZNF318 WDFY3 C2CD2	1.39e-06	195	65	7	1649_DN
Drug	Colchicine [64-86-8]; Down 200; 10uM; PC3; HT_HG-U133A	GTF2I CEP112 ZNF318 LIMCH1 WDFY3 GNAS USP21	1.39e-06	195	65	7	4614_DN
Drug	Prilocaine hydrochloride [1786-81-8]; Down 200; 15.6uM; MCF7; HT_HG-U133A	ATXN2L EXPH5 RANBP3 WDFY3 BCL9 ARID1A CIC	1.44e-06	196	65	7	2314_DN
Drug	clozapine; Down 200; 10uM; HL60; HT_HG-U133A	ATXN2L ZNF219 L3MBTL1 SZT2 RANBP3 MYO15A	1.82e-05	192	65	6	6188_DN
Drug	rosiglitazone; Up 200; 10uM; MCF7; HT_HG-U133A	RANBP3 YLPM1 ZNF318 GNAS MYO15A CHST8	2.04e-05	196	65	6	6950_UP
Drug	Ketoprofen [22071-15-4]; Down 200; 15.8uM; MCF7; HT_HG-U133A	WDR33 WDFY3 GNAS BCL9 ARID1A VAMP4	2.10e-05	197	65	6	4751_DN
Drug	Brinzolamide [138890-62-7]; Up 200; 10.4uM; MCF7; HT_HG-U133A	SZT2 IKBKE HIC2 LIMCH1 SRRM2 ADAMTSL4	2.10e-05	197	65	6	5016_UP
Drug	Meclocycline sulfosalicylate [73816-42-9]; Down 200; 5.8uM; MCF7; HT_HG-U133A	IKBKE RANBP3 HIC2 BCL9 SRRM2 CIC	2.10e-05	197	65	6	3277_DN
Drug	Esculin Hydrate [531-75-9]; Up 200; 11.8uM; PC3; HT_HG-U133A	ATXN2L GTF2I L3MBTL1 IKBKE RANBP3 ARID1A	2.10e-05	197	65	6	6310_UP
Drug	Azaperone [1649-18-9]; Down 200; 12.2uM; MCF7; HT_HG-U133A	SUGP2 RANBP3 ZNF318 BCL9 ARID1A CIC	2.10e-05	197	65	6	7231_DN
Drug	Roxarsone [121-19-7]; Up 200; 15.2uM; MCF7; HT_HG-U133A	ZNF219 SZT2 ZNF318 WDFY3 ADAMTSL4 CHST8	2.16e-05	198	65	6	5470_UP
Drug	Papaverine hydrochloride [61-25-6]; Up 200; 10.6uM; MCF7; HT_HG-U133A	ATXN2L IKBKE POM121L2 GNAS CIC CHST8	2.22e-05	199	65	6	2747_UP
Drug	Flurbiprofen [5104-49-4]; Up 200; 16.4uM; HL60; HT_HG-U133A	ZNF219 RANBP3 YLPM1 MYO15A PPP1R13L ARID1A	2.22e-05	199	65	6	3095_UP
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	GTF2I RANBP3 WDFY3 ARID1A SRRM2	1.40e-04	174	65	5	6493_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A	GTF2I WDR33 WDFY3 ARID1A SRRM2	1.56e-04	178	65	5	5086_DN
Drug	Azaguanine-8 [134-58-7]; Down 200; 26.2uM; PC3; HT_HG-U133A	PCF11 SUGP2 EXPH5 TBK1 ZNF318	1.69e-04	181	65	5	1791_DN
Drug	retinoic acid; Down 200; 1uM; HL60; HT_HG-U133A	ATXN2L ZNF219 MYO15A C2CD2 CIC	2.06e-04	189	65	5	6170_DN
Drug	17-DMAG; Down 200; 0.1uM; MCF7; HT_HG-U133A	PCF11 HIC2 ZNF318 BCL9 PPP1R13L	2.17e-04	191	65	5	5210_DN
Drug	Naltrexone hydrochloride dihydrate [16676-29-2]; Down 200; 9.6uM; HL60; HG-U133A	NEFH SUGP2 YLPM1 ZNF318 CIC	2.27e-04	193	65	5	1363_DN
Drug	felodipine; Down 200; 10uM; MCF7; HT_HG-U133A_EA	ABHD4 IKBKE RANBP3 PPP1R13L SRRM2	2.27e-04	193	65	5	965_DN
Drug	ICI 182,780; Up 200; 0.01uM; MCF7; HT_HG-U133A	POM121L2 LIMCH1 WDFY3 SRRM2 CIC	2.33e-04	194	65	5	5235_UP
Drug	Zalcitabine [7481-89-2]; Up 200; 19uM; MCF7; HT_HG-U133A	ATXN2L ZNF219 POM121L2 HIC2 CIC	2.33e-04	194	65	5	7352_UP
Drug	Menadione [58-27-5]; Down 200; 23.2uM; PC3; HT_HG-U133A	JCAD GTF2I IKBKE CEP112 WDFY3	2.33e-04	194	65	5	4662_DN
Drug	Tiabendazole [148-79-8]; Down 200; 19.8uM; MCF7; HT_HG-U133A	IKBKE RANBP3 WDFY3 CHPF CIC	2.33e-04	194	65	5	2840_DN
Drug	Betazole hydrochloride; Up 200; 27uM; PC3; HT_HG-U133A	RANBP3 WDFY3 BCL9 SRRM2 CHST8	2.33e-04	194	65	5	1812_UP
Drug	Kaempferol [520-18-3]; Down 200; 14uM; MCF7; HT_HG-U133A	ZNF219 SUGP2 YLPM1 WDFY3 VAMP4	2.33e-04	194	65	5	7196_DN
Drug	clofibrate; Up 200; 150uM; MCF7; HG-U133A	ATXN2L L3MBTL1 ZNF318 ARID1A ADAMTSL4	2.33e-04	194	65	5	263_UP
Drug	Prednisone [53-03-2]; Down 200; 11.2uM; MCF7; HT_HG-U133A	SUGP2 IKBKE EXPH5 HIC2 ZNF318	2.38e-04	195	65	5	1478_DN
Drug	Ifenprodil tartrate [23210-58-4]; Down 200; 8.4uM; MCF7; HT_HG-U133A	ATXN2L SUGP2 RANBP3 YLPM1 CIC	2.38e-04	195	65	5	7404_DN
Drug	Metyrapone [54-36-4]; Down 200; 17.6uM; MCF7; HT_HG-U133A	ZNF219 WDR33 RANBP3 WDFY3 BCL9	2.38e-04	195	65	5	5667_DN
Drug	haloperidol; Down 200; 10uM; MCF7; HT_HG-U133A	ATXN2L ZNF219 IKBKE CHPF SRRM2	2.38e-04	195	65	5	5241_DN
Drug	Cyclacillin [3485-14-1]; Up 200; 11.8uM; PC3; HT_HG-U133A	ATXN2L L3MBTL1 POM121L2 HIC2 MYO15A	2.38e-04	195	65	5	3800_UP
Drug	Isosorbide dinitrate [87-33-2]; Down 200; 17uM; MCF7; HT_HG-U133A	ATXN2L SZT2 IKBKE RANBP3 SRRM2	2.38e-04	195	65	5	4742_DN
Drug	Flecainide acetate [54143-56-5]; Up 200; 8.4uM; MCF7; HT_HG-U133A	KMT2D CEP112 HIC2 BCL9 KNG1	2.38e-04	195	65	5	3843_UP
Drug	(-)-depudecin; Down 200; 1uM; MCF7; HT_HG-U133A_EA	SUGP2 RANBP3 HIC2 SRRM2 USP21	2.44e-04	196	65	5	982_DN
Drug	Ioxaglic acid [59017-64-0]; Down 200; 3.2uM; MCF7; HT_HG-U133A	ABHD4 ATXN2L SUGP2 BCL9 SRRM2	2.44e-04	196	65	5	7470_DN
Drug	Khellin [82-02-0]; Down 200; 15.4uM; MCF7; HT_HG-U133A	ATXN2L IKBKE RANBP3 LIMCH1 SRRM2	2.44e-04	196	65	5	4987_DN
Drug	Zardaverine [101975-10-4]; Down 200; 15uM; MCF7; HT_HG-U133A	IKBKE EXPH5 RANBP3 PPP1R13L CIC	2.44e-04	196	65	5	4793_DN
Drug	Monocrotaline [315-22-0]; Down 200; 12.2uM; PC3; HT_HG-U133A	SUGP2 HIC2 LIMCH1 GNAS SRRM2	2.44e-04	196	65	5	7127_DN
Drug	Viomycin sulfate [37883-00-4]; Down 200; 5.2uM; MCF7; HT_HG-U133A	FLNC IKBKE RANBP3 ZNF318 CHST8	2.44e-04	196	65	5	3541_DN
Drug	haloperidol; Down 200; 10uM; HL60; HT_HG-U133A	ZNF219 L3MBTL1 WDR33 WDFY3 MYO15A	2.44e-04	196	65	5	6203_DN
Drug	Deptropine citrate [2169-75-7]; Up 200; 7.6uM; HL60; HT_HG-U133A	RANBP3 YLPM1 HIC2 SRRM2 CIC	2.44e-04	196	65	5	3144_UP
Drug	Nifedipine [21829-25-4]; Down 200; 11.6uM; MCF7; HT_HG-U133A	ZNF219 SUGP2 CLASP1 VAMP4 CIC	2.44e-04	196	65	5	1692_DN
Drug	Nomifensine maleate [32795-47-4]; Up 200; 11.2uM; MCF7; HT_HG-U133A	L3MBTL1 RANBP3 LIMCH1 GNAS MYO15A	2.50e-04	197	65	5	7217_UP
Drug	aspirin, USP; Down 200; 100uM; MCF7; HT_HG-U133A	ABHD4 ATXN2L SUGP2 RANBP3 ZNF318	2.50e-04	197	65	5	5201_DN
Drug	Chlorpheniramine maleate [113-92-8]; Down 200; 10.2uM; MCF7; HT_HG-U133A	IKBKE HIC2 ZNF318 LIMCH1 VAMP4	2.50e-04	197	65	5	6773_DN
Drug	Sulfabenzamide [127-71-9]; Down 200; 14.4uM; MCF7; HT_HG-U133A	ATXN2L RANBP3 LIMCH1 BCL9 CHPF	2.50e-04	197	65	5	2814_DN
Drug	Flutamide [13311-84-7]; Down 200; 14.4uM; MCF7; HT_HG-U133A	ZNF219 WDR33 HIC2 LIMCH1 GNAS	2.50e-04	197	65	5	3885_DN
Drug	Piromidic acid [19562-30-2]; Down 200; 13.8uM; MCF7; HT_HG-U133A	IKBKE WDR33 ZNF318 BCL9 SRRM2	2.50e-04	197	65	5	3335_DN
Drug	Iproniazide phosphate [305-33-9]; Down 200; 14.4uM; PC3; HT_HG-U133A	IKBKE YLPM1 WDFY3 PPP1R13L CHST8	2.50e-04	197	65	5	6359_DN
Drug	Meglumine [6284-40-8]; Up 200; 20.4uM; MCF7; HT_HG-U133A	SUGP2 LIMCH1 WDFY3 BCL9 SRRM2	2.50e-04	197	65	5	5285_UP
Drug	PNU-0230031 [267429-39-0]; Down 200; 10uM; MCF7; HT_HG-U133A	ATXN2L GTF2I IKBKE RANBP3 VAMP4	2.50e-04	197	65	5	4754_DN
Drug	prochlorperazine dimaleate salt; Down 200; 10uM; PC3; HT_HG-U133A	PCF11 CLASP1 YLPM1 HIC2 BCL9	2.50e-04	197	65	5	1215_DN
Drug	Ergocryptine-alpha [511-09-1]; Down 200; 7uM; MCF7; HT_HG-U133A	RANBP3 ARHGEF18 ZNF318 BCL9 CIC	2.56e-04	198	65	5	3434_DN
Drug	Dantrolene sodium salt [14663-23-1]; Down 200; 11.8uM; HL60; HT_HG-U133A	ABHD4 IKBKE RANBP3 HIC2 C2CD2	2.56e-04	198	65	5	2369_DN
Drug	Dequalinium dichloride [522-51-0]; Up 200; 7.6uM; PC3; HT_HG-U133A	L3MBTL1 IKBKE ARID1A CIC CHST8	2.56e-04	198	65	5	6296_UP
Drug	Sulfamethazine sodium salt [1981-58-4]; Down 200; 13.4uM; HL60; HT_HG-U133A	GTF2I RANBP3 GNAS VAMP4 C2CD2	2.56e-04	198	65	5	2560_DN
Drug	Calciferol [50-14-6]; Up 200; 10uM; PC3; HT_HG-U133A	KMT2D FZD10 HIC2 SRRM2 CIC	2.56e-04	198	65	5	6746_UP
Drug	estradiol, USP; Down 200; 0.1uM; MCF7; HT_HG-U133A	GTF2I SUGP2 CLASP1 RANBP3 ARID1A	2.56e-04	198	65	5	1633_DN
Drug	Naftifine hydrochloride [65473-14-5]; Up 200; 12.4uM; PC3; HT_HG-U133A	ABHD4 GTF2I WDR33 RANBP3 WDFY3	2.56e-04	198	65	5	7273_UP
Drug	haloperidol; Down 200; 10uM; MCF7; HT_HG-U133A	WDR33 YLPM1 HIC2 ZNF318 BCL9	2.56e-04	198	65	5	7003_DN
Drug	Cyclopentolate hydrochloride [5870-29-1]; Down 200; 12.2uM; MCF7; HT_HG-U133A	ZNF219 RANBP3 LIMCH1 WDFY3 BCL9	2.56e-04	198	65	5	3555_DN
Drug	Sulfasalazine [599-79-1]; Down 200; 10uM; PC3; HT_HG-U133A	GTF2I IKBKE YLPM1 SRRM2 USP21	2.56e-04	198	65	5	6346_DN
Drug	Isocorydine (+) [475-67-2]; Up 200; 11.8uM; PC3; HT_HG-U133A	ZNF219 RANBP3 HIC2 MYO15A ARID1A	2.56e-04	198	65	5	4505_UP
Drug	Ceforanide [60925-61-3]; Up 200; 7.6uM; PC3; HT_HG-U133A	ATXN2L KMT2D POM121L2 HIC2 MYO15A	2.56e-04	198	65	5	6751_UP
Drug	Iobenguane sulfate; Up 200; 10.8uM; MCF7; HT_HG-U133A	ATXN2L SZT2 POM121L2 LIMCH1 BCL9	2.56e-04	198	65	5	2878_UP
Drug	Evoxine [522-11-2]; Down 200; 11.6uM; PC3; HT_HG-U133A	JCAD IKBKE ARID1A SRRM2 CHST8	2.56e-04	198	65	5	3681_DN
Drug	Baclofen (R,S) [1134-47-0]; Up 200; 18.8uM; MCF7; HT_HG-U133A	ATXN2L GTF2I RANBP3 ZNF318 LIMCH1	2.56e-04	198	65	5	5414_UP
Drug	Furaltadone hydrochloride [3759-92-0]; Down 200; 11uM; MCF7; HT_HG-U133A	ZNF219 SUGP2 RANBP3 ZNF318 BCL9	2.56e-04	198	65	5	3413_DN
Drug	Pronethalol hydrochloride [51-02-5]; Up 200; 15uM; MCF7; HT_HG-U133A	ATXN2L L3MBTL1 ZNF318 LIMCH1 KNG1	2.56e-04	198	65	5	4104_UP
Drug	Prazosin hydrochloride [19237-84-4]; Up 200; 9.6uM; PC3; HT_HG-U133A	GTF2I L3MBTL1 SZT2 IKBKE RANBP3	2.56e-04	198	65	5	6315_UP
Drug	Adrenosterone [382-45-6]; Down 200; 13.4uM; MCF7; HT_HG-U133A	ZNF219 IKBKE EXPH5 YLPM1 CHST8	2.56e-04	198	65	5	6486_DN
Drug	(+/-)-verapamil hydrochloride; Up 200; 10uM; MCF7; HG-U133A	ATXN2L L3MBTL1 SUGP2 ARID1A ADAMTSL4	2.56e-04	198	65	5	161_UP
Drug	N6,2-O-dibutyryladenosine 3,5-cyclic monophosphate sodium salt; Up 200; 2uM; MCF7; HT_HG-U133A_EA	ZNF219 SUGP2 SZT2 WDFY3 VAMP4	2.56e-04	198	65	5	842_UP
Drug	wortmannin from Penicillium funiculosum; Down 200; 0.01uM; HL60; HT_HG-U133A	L3MBTL1 WDR33 HIC2 WDFY3 MYO15A	2.56e-04	198	65	5	6202_DN
Drug	Procaine hydrochloride [51-05-8]; Down 200; 14.6uM; PC3; HT_HG-U133A	JCAD CLASP1 YLPM1 CHST8 USP21	2.56e-04	198	65	5	6329_DN
Drug	clofibrate; Up 200; 100uM; MCF7; HG-U133A	FLNC ZNF219 YLPM1 POM121L2 GNAS	2.62e-04	199	65	5	444_UP
Drug	(R)-(+)-Atenolol [56715-13-0]; Down 200; 15uM; MCF7; HT_HG-U133A	ZNF219 WDR33 EXPH5 RANBP3 CHST8	2.62e-04	199	65	5	2855_DN
Drug	Hexylcaine hydrochloride [532-76-3]; Down 200; 13.4uM; MCF7; HT_HG-U133A	ABHD4 ZNF219 RANBP3 YLPM1 PPP1R13L	2.62e-04	199	65	5	6244_DN
Drug	Bemegride [64-65-3]; Down 200; 25.8uM; MCF7; HT_HG-U133A	SUGP2 POM121L2 LIMCH1 BCL9 ARID1A	2.62e-04	199	65	5	5014_DN
Drug	Doxylamine succinate [562-10-7]; Up 200; 10.2uM; MCF7; HT_HG-U133A	ATXN2L L3MBTL1 IKBKE HIC2 WDFY3	2.62e-04	199	65	5	4819_UP
Drug	Ketanserin tartrate hydrate [83846-83-7]; Up 200; 7uM; MCF7; HT_HG-U133A	IKBKE RANBP3 FZD10 GNAS SRRM2	2.62e-04	199	65	5	4995_UP
Drug	estradiol, USP; Down 200; 0.01uM; MCF7; HT_HG-U133A	ZNF219 IKBKE YLPM1 LIMCH1 WDFY3	2.62e-04	199	65	5	5601_DN
Drug	Oxymetazoline hydrochloride [2315-02-8]; Down 200; 13.4uM; PC3; HT_HG-U133A	GTF2I CEP112 RANBP3 ZNF318 BCL9	2.62e-04	199	65	5	6350_DN
Drug	Benzydamine hydrochloride [132-69-4]; Up 200; 11.6uM; MCF7; HT_HG-U133A	SZT2 IKBKE POM121L2 MYO15A ADAMTSL4	2.62e-04	199	65	5	3169_UP
Drug	Nystatine [1400-61-9]; Down 200; 4.4uM; MCF7; HT_HG-U133A	GTF2I SUGP2 YLPM1 LIMCH1 VAMP4	2.68e-04	200	65	5	4807_DN
Drug	Orlistat; Down 200; 10uM; MCF7; HT_HG-U133A	IKBKE RANBP3 POM121L2 HIC2 WDFY3	2.68e-04	200	65	5	6415_DN
Drug	Apramycin [37321-09-8]; Down 200; 7.4uM; MCF7; HT_HG-U133A	ZNF219 RANBP3 YLPM1 ZNF318 LIMCH1	2.68e-04	200	65	5	4959_DN
Disease	hemangioblastoma (is_marker_for)	DLL4 NOTCH4	2.68e-05	4	63	2	DOID:5241 (is_marker_for)
Disease	hemangiopericytoma (is_marker_for)	DLL4 NOTCH4	1.60e-04	9	63	2	DOID:264 (is_marker_for)
Disease	platelet crit	JCAD CEP112 EXPH5 CCBE1 YLPM1 ZNF318 ADGRV1 ARID1A C2CD2	1.81e-04	952	63	9	EFO_0007985
Disease	T-Cell Lymphoma	KMT2D ARID1A	5.28e-04	16	63	2	C0079772
Disease	Tachyarrhythmia	GNAS KNG1	6.71e-04	18	63	2	C0080203
Disease	Tachycardia	GNAS KNG1	6.71e-04	18	63	2	C0039231
Disease	polycystic kidney disease (biomarker_via_orthology)	DLL4 GNAS	7.49e-04	19	63	2	DOID:0080322 (biomarker_via_orthology)
Disease	Intrahepatic Cholangiocarcinoma	GNAS ARID1A	1.20e-03	24	63	2	C0345905
Disease	Extrahepatic Cholangiocarcinoma	GNAS ARID1A	1.20e-03	24	63	2	C3805278
Disease	Cholangiocarcinoma	GNAS ARID1A	1.41e-03	26	63	2	C0206698
Disease	Sezary Syndrome	KMT2D ARID1A	1.52e-03	27	63	2	C0036920
Disease	blood vanadium measurement	FZD10 GNAS	1.88e-03	30	63	2	EFO_0021533
Disease	Malignant neoplasm of breast	KMT2D DLL4 RNF149 ZNF318 CLSPN ARID1A CIC NOTCH4	1.97e-03	1074	63	8	C0006142
Disease	glycoprotein measurement	CEP112 POM121L2 ADGRV1	2.13e-03	119	63	3	EFO_0004555

Protein segments in the cluster

Peptide	Gene	Start	Entry
PQPRGLFRGGDPSET	ARHGEF18	851	Q6ZSZ5
PVARGGSPARFPGFR	ADM5	81	C9JUS6
GSPARFPGFRPAARG	ADM5	86	C9JUS6
EGGFFRASPQPRRPS	ADAMTSL4	271	Q6UY14
FPVFCGDPGVPSRGR	CSMD2	3066	Q7Z408
DPGGVFEFSPASRGP	ADGRV1	771	Q8WXG9
RGALEGPFTHRPEPG	CEP112	76	Q8N8E3
GFVGSRCEFPVGLPP	DLL4	511	Q9NR61
GRSSRPAFPRDPEGA	ABHD4	106	Q8TB40
PGFPGGADDRIREFS	ATXN2L	1036	Q8WWM7
PPFPRELAGRSAGGS	RANBP3	86	Q9H6Z4
PFQFGRDRVSAPPGT	ARID1A	1456	O14497
TARRGPGESADPGPF	CASKIN1	1076	Q8WXD9
GPRRGSGPEIFTFDP	IER3	26	P46695
EPGVRSFGFPDPQSR	HAPLN3	336	Q96S86
GFGPEFGRPVPRPAT	MYO15A	556	Q9UKN7
SPGRFRVEEGGGAPF	JCAD	931	Q9P266
TGSLPFIPFGGPRRN	IKBKE	216	Q14164
TEAAAPPPGGGLRFR	L3MBTL1	86	Q9Y468
SFDGRGPPGPESQSR	NCOA5	151	Q9HCD5
ITFGGRPIPGSPFRV	FLNC	1421	Q14315
RPGTPREGFKTFSPR	EXPH5	276	Q8NEV8
PPDETFGGRVPRPAF	PELP1	751	Q8IZL8
FRFEGSPGLRFEGSP	PCF11	846	O94913
CRIGFGPIPFSLPEG	NEFH	411	P12036
DEPTRGSGLFPPLFR	FZD10	156	Q9ULW2
PGGPEARGFAPLLDF	BCL6B	81	Q8N143
RKGGPPFLSFEEDPR	C2CD2	91	Q9Y426
VFPVRPGSGRPEGGA	ATPAF1	46	Q5TC12
IFSGPGRGERFPNPQ	BCL9	611	O00512
RGSPGPPGSFDFLLL	CCBE1	326	Q6UXH8
RPPGFSPFRSSRIGE	KNG1	381	P01042
GPGTRVSPAAFFPLR	C2orf81	391	A6NN90
RAPAPRGGFAVPSGE	FIGNL2	351	A6NMB9
EGVPFRRPSTFGIPR	GTF2I	776	P78347
PPTPFDFLGRAGSPR	PPP1R13L	171	Q8WUF5
EGPQAFFPERGPSPR	PPP1R13L	191	Q8WUF5
GGERPFRYGPRTPVS	LIMCH1	306	Q9UPQ0
PPASPRDGATGFGVR	GAREM2	781	Q75VX8
AGSPFERREAGPKGP	HIC2	346	Q96JB3
LPEPFSGDPGRLAGF	RTL6	101	Q6ICC9
SRGGGPLPLDTFPFD	SZT2	2751	Q5T011
PSPASGRRGEGDAPF	SRRM2	296	Q9UQ35
FFLRGPSGPRFGPRN	VAMP4	36	O75379
QRPAPESRGGFQPFG	RNF5	101	Q99942
QEREGFLPSRGPAPG	SLC38A5	21	Q8WUX1
EGFGDDSPPPGLSRV	GNAS	231	Q5JWF2
ATPGREAGPFPRART	NOTCH4	1831	Q99466
FPPAQGSVGRGPFRS	POM121L2	991	Q96KW2
SFEAGASGRPGPAPR	CIC	1191	Q96RK0
GPGPPELGRDTGRFD	CHPF	656	Q8IZ52
DAPFIRPGPGTLDGR	CHST8	131	Q9H2A9
PTAGGFRSPSPGLFR	CLSPN	801	Q9HAW4
PARGFPPLDRFGLGQ	CLASP1	766	Q7Z460
APDTRFFVPEPGGRG	RNF149	91	Q8NC42
FPALIPGEPGRSFEG	ZNF157	11	P51786
GGFPGPPTLFSIRTE	USP21	161	Q9UK80
GIGSGERFFPPPSGL	WDFY3	1086	Q8IZQ1
GREGLRSDVFPGPSF	SUGP2	76	Q8IX01
SSYLESPRGPRFDGP	YLPM1	751	P49750
DFGRDRGPFRPEPGD	YLPM1	1161	P49750
GPSASFPRERGLPQG	TBX4	486	P57082
TPDEFPRFEGGRKPD	WDR33	1166	Q9C0J8
RRLFPPGPAGFRGSS	ZNF318	96	Q5VUA4
AEPGPGRSFGGFRPL	ZNF219	396	Q9P2Y4
TGSLPFRPFEGPRRN	TBK1	216	Q9UHD2
RERGGFFSPEPGEPD	KMT2D	1956	O14686
RLGPGFRPDGDFPAD	NAALADL1	316	Q9UQQ1