Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontetrapyrrole binding

CYP4Z2P CYP2J2 CYP4B1 CYP11A1 MTR CYP2S1 PTGS1

3.29e-06164777GO:0046906
GeneOntologyMolecularFunctionmonooxygenase activity

CYP4Z2P MOXD1 CYP2J2 CYP4B1 CYP11A1 CYP2S1

5.44e-06115776GO:0004497
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

CYP4Z2P MOXD1 CYP2J2 CYP4B1 CYP11A1 CYP2S1 PTGS1

9.93e-06194777GO:0016705
GeneOntologyMolecularFunctionheme binding

CYP4Z2P CYP2J2 CYP4B1 CYP11A1 CYP2S1 PTGS1

2.88e-05154776GO:0020037
GeneOntologyMolecularFunctionaromatase activity

CYP2J2 CYP4B1 CYP2S1

3.30e-0435773GO:0070330
GeneOntologyMolecularFunctionubiquitin conjugating enzyme activity

UBE2R2 CDC34 TAF1L

3.90e-0437773GO:0061631
GeneOntologyMolecularFunctioniron ion binding

CYP4Z2P CYP2J2 CYP4B1 CYP11A1 CYP2S1

4.56e-04166775GO:0005506
GeneOntologyMolecularFunctionubiquitin-like protein conjugating enzyme activity

UBE2R2 CDC34 TAF1L

6.09e-0443773GO:0061650
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

CYP2J2 CYP4B1 CYP2S1

8.94e-0449773GO:0016712
DomainCyt_P450_E_grp-I

CYP2J2 CYP4B1 CYP11A1 CYP2S1

2.83e-0545734IPR002401
DomainCyt_P450_CS

CYP2J2 CYP4B1 CYP11A1 CYP2S1

5.44e-0553734IPR017972
DomainCYTOCHROME_P450

CYP2J2 CYP4B1 CYP11A1 CYP2S1

7.25e-0557734PS00086
Domain-

CYP2J2 CYP4B1 CYP11A1 CYP2S1

7.77e-05587341.10.630.10
Domainp450

CYP2J2 CYP4B1 CYP11A1 CYP2S1

7.77e-0558734PF00067
DomainCyt_P450

CYP2J2 CYP4B1 CYP11A1 CYP2S1

8.88e-0560734IPR001128
DomainTMEM14

TMEM14B TMEM14DP

1.50e-045732IPR005349
DomainTmemb_14

TMEM14B TMEM14DP

1.50e-045732PF03647
DomainBromodomain

BPTF ZMYND8 TAF1L

4.38e-0438733PF00439
DomainBROMODOMAIN_2

BPTF ZMYND8 TAF1L

5.49e-0441733PS50014
DomainBROMO

BPTF ZMYND8 TAF1L

5.89e-0442733SM00297
DomainBromodomain

BPTF ZMYND8 TAF1L

5.89e-0442733IPR001487
Domain-

BPTF ZMYND8 TAF1L

5.89e-04427331.20.920.10
DomainDOCK_C

DOCK5 DOCK7

8.10e-0411732IPR010703
DomainDHR-1_domain

DOCK5 DOCK7

8.10e-0411732IPR027007
DomainDHR_2

DOCK5 DOCK7

8.10e-0411732PS51651
DomainDHR_1

DOCK5 DOCK7

8.10e-0411732PS51650
DomainDOCK-C2

DOCK5 DOCK7

8.10e-0411732PF14429
DomainDHR-2

DOCK5 DOCK7

8.10e-0411732IPR027357
DomainDHR-2

DOCK5 DOCK7

8.10e-0411732PF06920
DomainDOCK

DOCK5 DOCK7

8.10e-0411732IPR026791
DomainUIM

ANKIB1 USP37

2.21e-0318732PF02809
DomainZnf_FYVE_PHD

BPTF ZMYND8 ANKIB1 RIMS2

2.63e-03147734IPR011011
DomainUIM

ANKIB1 USP37

3.02e-0321732SM00726
Domainfn3

NEO1 COL12A1 EGFLAM ITGB4

3.73e-03162734PF00041
DomainUIM

ANKIB1 USP37

3.93e-0324732PS50330
DomainUBQ-conjugating_AS

UBE2R2 CDC34

4.26e-0325732IPR023313
DomainUIM_dom

ANKIB1 USP37

4.26e-0325732IPR003903
DomainBromodomain_CS

BPTF TAF1L

4.61e-0326732IPR018359
DomainFN3

NEO1 COL12A1 EGFLAM ITGB4

5.96e-03185734SM00060
DomainFN3

NEO1 COL12A1 EGFLAM ITGB4

7.68e-03199734PS50853
PathwayREACTOME_BIOLOGICAL_OXIDATIONS

CYP2J2 CYP4B1 CYP11A1 MTR CYP2S1 UGT2B28 PTGS1

3.41e-05219597MM14838
PathwayREACTOME_BIOLOGICAL_OXIDATIONS

CYP2J2 CYP4B1 CYP11A1 MTR CYP2S1 UGT2B28 PTGS1

3.51e-05220597M10320
PathwayREACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS

CYP2J2 CYP4B1 CYP11A1 CYP2S1 PTGS1

7.24e-05104595M738
PathwayREACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS

CYP2J2 CYP4B1 CYP11A1 CYP2S1 PTGS1

7.58e-05105595MM14842
PathwayBIOCARTA_EICOSANOID_PATHWAY

CYP2J2 PTGES PTGS1

1.01e-0422593M22003
PathwayREACTOME_ARACHIDONIC_ACID_METABOLISM

CYP2J2 CYP4B1 PTGES PTGS1

1.06e-0459594M27140
PathwayREACTOME_ARACHIDONIC_ACID_METABOLISM

CYP2J2 CYP4B1 PTGES PTGS1

1.21e-0461594MM14861
PathwayWP_OXIDATION_BY_CYTOCHROME_P450

CYP2J2 CYP4B1 CYP11A1 CYP2S1

1.29e-0462594M39653
PathwayREACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE

CYP2J2 CYP4B1 CYP11A1 CYP2S1

1.46e-0464594M5650
PathwayREACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE

CYP2J2 CYP4B1 CYP11A1 CYP2S1

1.64e-0466594MM14839
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

DOCK5 LIG4 TMEM14B DOCK7 ANKIB1 MTR TMEM14DP CDC25B ANKHD1 RFWD3 HELLS

2.24e-07650781138777146
Pubmed

Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.

CYP4Z2P CYP2J2 CYP4B1 CYP11A1 CYP2S1

5.38e-077078515128046
Pubmed

BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates.

UBE2R2 MRPL37 CCDC138 MTR EGFLAM CDC25B CDC34

7.96e-0722678725900982
Pubmed

Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues.

CYP2J2 CYP4B1 CYP11A1 CYP2S1

2.97e-064478412745259
Pubmed

Human transcription factor protein interaction networks.

SFXN1 BPTF ACACB GTF3C2 PITRM1 DNAH10 MRPL37 CCDC138 ZMYND8 MTR GRN ANKHD1 TAF1L HELLS

3.20e-061429781435140242
Pubmed

Defective generation of a humoral immune response is associated with a reduced incidence and severity of collagen-induced arthritis in microsomal prostaglandin E synthase-1 null mice.

PTGES PTGS1

4.97e-06278218523303
Pubmed

Expression of cytochrome P450 genes encoding enzymes active in the metabolism of tamoxifen in human uterine endometrium.

CYP4B1 CYP11A1

4.97e-0627829498238
Pubmed

Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles.

RTTN STIL

4.97e-06278228811500
Pubmed

Up-regulation of microsomal prostaglandin E synthase-1 in COX-1 and COX-2 knock-out mouse fibroblast cell lines.

PTGES PTGS1

4.97e-06278219114118
Pubmed

Regulation of the microsomal prostaglandin E synthase-1 in polarized mononuclear phagocytes and its constitutive expression in neutrophils.

PTGES PTGS1

4.97e-06278217505022
Pubmed

Cyclooxygenase-1 and -2 Play Contrasting Roles in Listeria-Stimulated Immunity.

PTGES PTGS1

4.97e-06278229678951
Pubmed

Combined variants in factor VIII and prostaglandin synthase-1 amplify hemorrhage severity across three generations of descendants.

F8 PTGS1

4.97e-06278227629384
Pubmed

The impact of microsomal prostaglandin e synthase 1 on blood pressure is determined by genetic background.

PTGES PTGS1

4.97e-06278220065147
Pubmed

The coupling of alpha6beta4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation.

GRB2 ITGB4

4.97e-0627829171350
Pubmed

Increased lethality and defective pulmonary clearance of Streptococcus pneumoniae in microsomal prostaglandin E synthase-1-knockout mice.

PTGES PTGS1

4.97e-06278227059285
Pubmed

Distribution of microsomal prostaglandin E synthase-1 in the mouse brain.

PTGES PTGS1

4.97e-06278224668417
Pubmed

Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry.

BPTF CYP2J2 RIMS2 PTGS1

7.32e-065578418570454
Pubmed

Identification of the Mitochondrial Heme Metabolism Complex.

SFXN1 TMEM14B TMEM14DP

1.40e-052178326287972
Pubmed

TMEM14C is required for erythroid mitochondrial heme metabolism.

TMEM14B TMEM14DP

1.49e-05378225157825
Pubmed

The communal relation of MTHFR, MTR, ACE gene polymorphisms and hyperhomocysteinemia as conceivable risk of coronary artery disease.

MTR ACE

1.49e-05378228514598
Pubmed

Prostaglandin E(2) produced by the lung augments the effector phase of allergic inflammation.

PTGES PTGS1

1.49e-05378222412193
Pubmed

DOCK7 is a critical regulator of the RAGE-Cdc42 signaling axis that induces formation of dendritic pseudopodia in human cancer cells.

AGER DOCK7

1.49e-05378223254359
Pubmed

Inducible prostaglandin E2 synthesis interacts in a temporally supplementary sequence with constitutive prostaglandin-synthesizing enzymes in creating the hypothalamic-pituitary-adrenal axis response to immune challenge.

PTGES PTGS1

1.49e-05378219193887
Pubmed

Relationship of the Topological Distances and Activities between mPGES-1 and COX-2 versus COX-1: Implications of the Different Post-Translational Endoplasmic Reticulum Organizations of COX-1 and COX-2.

PTGES PTGS1

1.49e-05378225988363
Pubmed

Genetic polymorphisms of CYP2S1, CYP2J2 and CYP2R1 genes in three Chinese populations: Han, Tibetan and Uighur.

CYP2J2 CYP2S1

1.49e-05378230019995
Pubmed

Advanced glycation end product-mediated matrix metallo-proteinase-9 and apoptosis via renin-angiotensin system in type 2 diabetes.

AGER ACE

1.49e-05378220215707
Pubmed

Tetra primer ARMS-PCR relates folate/homocysteine pathway genes and ACE gene polymorphism with coronary artery disease.

MTR ACE

1.49e-05378221567207
Pubmed

Immunohistochemical localization of microsomal PGE synthase-1 and cyclooxygenases in male mouse reproductive organs.

PTGES PTGS1

1.49e-05378212021206
Pubmed

COX-1 is coupled with mPGES-1 and ABCC4 in human cervix cancer cells.

PTGES PTGS1

1.49e-05378219399588
Pubmed

Cutting Edge: Murine NK Cells Degranulate and Retain Cytotoxic Function without Store-Operated Calcium Entry.

STIM2 NCR1

1.49e-05378228794231
Pubmed

Membrane-associated PGE synthase-1 (mPGES-1) is coexpressed with both COX-1 and COX-2 in the kidney.

PTGES PTGS1

1.49e-05378215086459
Pubmed

RAGE drives the development of glomerulosclerosis and implicates podocyte activation in the pathogenesis of diabetic nephropathy.

AGER DOCK7

1.49e-05378212651605
Pubmed

Association of genetic variants with hemorrhagic stroke in Japanese individuals.

UBE2R2 PITRM1 USP37 ACE TBL3

1.82e-0514378520198315
Pubmed

Structural and functional consequences of NEDD8 phosphorylation.

UBE2R2 GRN ANKHD1 CDC34

1.92e-057078434642328
Pubmed

Protein composition of axonal dopamine release sites in the striatum.

SYT1 RIMS2

2.97e-05478236579890
Pubmed

Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function.

PTGES PTGS1

2.97e-05478216614756
Pubmed

Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes.

GRB2 ITGB4

2.97e-0547827556090
Pubmed

Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2.

PTGES PTGS1

2.97e-05478212835322
Pubmed

Alpha 6 integrins participate in pro-T cell homing to the thymus.

ITGB4 F8

2.97e-0547827621877
Pubmed

[Polymorphic markers of the CYP1B1 (4326C > G), CYP2F1 (c.14_15insC), CYP2J2 (-76G > T), and CYP2S1 (13106C > T and 13255A > G) genes and genetic predisposition to chronic respiratory diseases induced by smoking and occupational factors].

CYP2J2 CYP2S1

2.97e-05478222232929
Pubmed

A context-dependent and disordered ubiquitin-binding motif.

UBE2R2 CDC34

2.97e-05478235974206
Pubmed

Mapping of the CYP2J cytochrome P450 genes to human chromosome 1 and mouse chromosome 4.

CYP2J2 DOCK7

2.97e-0547829570962
Pubmed

Pulmonary and cardiorenal cyclooxygenase-1 (COX-1), -2 (COX-2), and microsomal prostaglandin E synthase-1 (mPGES-1) and -2 (mPGES-2) expression in a hypertension model.

PTGES PTGS1

2.97e-05478217641732
Pubmed

Coupling of COX-1 to mPGES1 for prostaglandin E2 biosynthesis in the murine mammary gland.

PTGES PTGS1

2.97e-05478216204198
Pubmed

Characterization of the prostaglandin biosynthetic pathway in non-small cell lung cancer: a comparison with small cell lung cancer and correlation with angiogenesis, angiogenic factors and metastases.

PTGES PTGS1

2.97e-05478215870920
Pubmed

c-Jun N-terminal kinase-mediated stabilization of microsomal prostaglandin E2 synthase-1 mRNA regulates delayed microsomal prostaglandin E2 synthase-1 expression and prostaglandin E2 biosynthesis by cardiomyocytes.

PTGES PTGS1

2.97e-05478216627484
Pubmed

Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development.

NEO1 ZMYND8 TAF1L

4.66e-053178325838543
Pubmed

Mechanism of Lysine 48 Selectivity during Polyubiquitin Chain Formation by the Ube2R1/2 Ubiquitin-Conjugating Enzyme.

UBE2R2 CDC34

4.94e-05578227044868
Pubmed

[Folate gene polymorphism and the risk of Down syndrome pregnancies in young Chinese women].

SLC19A2 MTR

4.94e-05578220466634
Pubmed

Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins.

DOCK5 DOCK7

4.94e-05578222158624
Pubmed

The cyclooxygenase-1/mPGES-1/endothelial prostaglandin EP4 receptor pathway constrains myocardial ischemia-reperfusion injury.

PTGES PTGS1

4.94e-05578231015404
Pubmed

Skp1-Cul1-F-box ubiquitin ligase (SCF(βTrCP))-mediated destruction of the ubiquitin-specific protease USP37 during G2-phase promotes mitotic entry.

USP37 CDC34

7.40e-05678223027877
Pubmed

Common polymorphisms and cardiovascular factors in patients with myocardial infarction of Costa Rica.

ACE F8

7.40e-05678218457169
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

SFXN1 GTF3C2 PITRM1 DNAH10 PRMT5 MRPL37 DOCK7 MTR PRDM7 ANKHD1 TBL3 HELLS

7.60e-051425781230948266
Pubmed

Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis.

TMEM14B TMEM14DP

1.04e-04778219656490
Pubmed

Common polymorphisms in the prostaglandin pathway genes and their association with breast cancer susceptibility and survival.

PTGES PTGS1

1.04e-04778219276290
Pubmed

Contribution of Prostaglandin Transporter OATP2A1/SLCO2A1 to Placenta-to-Maternal Hormone Signaling and Labor Induction.

PTGES PTGS1

1.38e-04878232408168
Pubmed

Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke.

PTGES PTGS1

1.38e-04878219046748
Pubmed

CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation.

UBE2R2 CDC34

1.38e-04878212037680
Pubmed

A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.

UBE2R2 DOCK7 USP37 CDC25B CDC34

1.80e-0423278525515538
Pubmed

Determination of genetic predisposition to patent ductus arteriosus in preterm infants.

CYP11A1 PTGES MTR PTGS1

2.08e-0412978419336370
Pubmed

Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members.

PRMT5 PIWIL4

2.21e-041078219584108
Pubmed

Expression patterns of mouse and human CYP orthologs (families 1-4) during development and in different adult tissues.

CYP4B1 CYP2S1

2.21e-041078215752708
Pubmed

Fever During Localized Inflammation in Mice Is Elicited by a Humoral Pathway and Depends on Brain Endothelial Interleukin-1 and Interleukin-6 Signaling and Central EP3 Receptors.

PTGES PTGS1

2.21e-041078233941650
Pubmed

Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways.

UBE2R2 CDC34

2.21e-041078231868589
Pubmed

Disrupted gonadogenesis and male-to-female sex reversal in Pod1 knockout mice.

TCF21 CYP11A1

2.70e-041178215289436
Pubmed

Oxidative damage to biological macromolecules in Prague bus drivers and garagemen: impact of air pollution and genetic polymorphisms.

MTR EPHX3

2.70e-041178220723587
Pubmed

Analysis of Netrin 1 receptors during inner ear development.

NEO1 ITGB4

2.70e-041178217616930
Pubmed

PCR isolation and cloning of novel splice variant mRNAs from known drug target genes.

CYP2J2 CYP4B1 PTGS1

2.76e-045678315028279
Pubmed

Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.

UBE2R2 PITRM1 USP37 ACE

3.01e-0414278419851296
Pubmed

Polymorphisms in DNA repair genes modulate survival in cisplatin/gemcitabine-treated non-small-cell lung cancer patients.

LIG4 MTR

3.23e-041278216407418
Pubmed

Common genetic variation, residential proximity to traffic exposure, and left ventricular mass: the multi-ethnic study of atherosclerosis.

ACE PTGS1

3.23e-041278220308035
Pubmed

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network.

UBE2R2 DZIP3 CDC34 RFWD3

3.61e-0414978419549727
Pubmed

A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.

BPTF ACACB GRB2 EFCAB3 STIL CDC25B

3.69e-0442078628065597
Pubmed

Neuronal Ceroid-Lipofuscinoses – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY

CLN6 GRN

3.81e-041378220301601
Pubmed

Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice.

PTGES PTGS1

3.81e-041378226690700
Pubmed

Ubiquitination of STING at lysine 224 controls IRF3 activation.

UBE2R2 CDC34

3.81e-041378228763789
Pubmed

Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord.

MOXD1 PKD1L1 OSBPL5 PIWIL4

4.29e-0415678422008794
Pubmed

Loss of all 3 Extended Synaptotagmins does not affect normal mouse development, viability or fertility.

OSBPL5 SYT1

4.44e-041478227399837
Pubmed

Easi-CRISPR: a robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins.

COL12A1 SYT1

4.44e-041478228511701
Pubmed

Local abnormalities in coagulation and fibrinolytic pathways predispose to alveolar fibrin deposition in the adult respiratory distress syndrome.

PTGES PTGS1

4.44e-04147822788176
Pubmed

Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.

DOCK5 DOCK7

4.44e-041478212432077
Pubmed

ALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQ.

ACACB PRMT5 MRPL37 STIL ANKHD1 TBL3 HELLS

5.08e-0462478733729478
Pubmed

SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation.

SYT1 RIMS2

5.12e-041578223999003
Pubmed

A signaling pathway involving TGF-beta2 and snail in hair follicle morphogenesis.

GRB2 ITGB4

5.12e-041578215630473
Pubmed

A mitochondrial protein compendium elucidates complex I disease biology.

SFXN1 ACP6 OMA1 ACACB PITRM1 CYP11A1 MRPL37 TMEM14B TMEM14DP

5.57e-04104778918614015
Pubmed

Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway?

PRMT5 PIWIL4

5.84e-041678216787967
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

TBC1D9B DOCK7 ANKIB1 MTR KIAA2013

7.06e-0431378538270169
Pubmed

Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration.

UBE2R2 GRB2 SYT1

7.59e-047978327325702
Pubmed

A candidate gene approach to genetic prognostic factors of IgA nephropathy--a result of Polymorphism REsearch to DIstinguish genetic factors Contributing To progression of IgA Nephropathy (PREDICT-IgAN).

CYP2J2 MTR ACE

7.87e-048078319420105
Pubmed

Identification of genetic factors associated with susceptibility to angiotensin-converting enzyme inhibitors-induced cough.

PTGES ACE

8.28e-041978221052031
Pubmed

Loss of Glis3 causes dysregulation of retrotransposon silencing and germ cell demise in fetal mouse testis.

CYP11A1 PIWIL4

8.28e-041978229941866
Pubmed

WT1 maintains adrenal-gonadal primordium identity and marks a population of AGP-like progenitors within the adrenal gland.

TCF21 CYP11A1

9.19e-042078224135228
Pubmed

Expression profile analysis of vulnerable CA1 pyramidal neurons in young-Middle-Aged Ts65Dn mice.

BPTF AGER PTGS1

9.39e-048578325131634
Pubmed

Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.

OMA1 GTF3C2 PITRM1 MRPL37 DOCK7 PTGS1

1.07e-0351578631617661
Pubmed

HERC5/IFI16/p53 signaling mediates breast cancer cell proliferation and migration.

UBE2R2 DZIP3 CDC34

1.11e-039078335671810
Pubmed

Genetic risk factors for cerebrovascular disease in children with sickle cell disease: design of a case-control association study and genomewide screen.

ACE F8

1.11e-032278212871600
Pubmed

A Large-scale genetic association study of esophageal adenocarcinoma risk.

LIG4 COL12A1 PTGES MTR PTGS1

1.18e-0335178520453000
Pubmed

The MALDI-TOF E2/E3 Ligase Assay as Universal Tool for Drug Discovery in the Ubiquitin Pathway.

UBE2R2 CDC34

1.22e-032378230017913
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

GTF3C2 PITRM1 OSBPL5 ANKIB1 ANKHD1 RIMS2

1.23e-0352978614621295
CytobandEnsembl 112 genes in cytogenetic band chr1p33

CYP4Z2P CYP4B1 STIL

1.58e-0461783chr1p33
CytobandEnsembl 112 genes in cytogenetic band chr1p32

OMA1 CYP2J2 MRPL37

2.39e-03155783chr1p32
CoexpressionGSE27859_DC_VS_CD11C_INT_F480_HI_MACROPHAGE_DN

SFXN1 TTC7A DOCK5 PITRM1 CLN6 CDC34

6.23e-06158756M8595
ToppCellrenal_papilla_nuclei-Adult_normal_reference|renal_papilla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

MOXD1 COL12A1 ACACB ASPA MTR SYT1 PTGS1

4.32e-081927776c106b91e46eabbe686a52a65a9c94ad9cbe9390
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Neuronal-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK5 MOXD1 COL12A1 ASPA EGFLAM ITGB4

8.03e-07184776e33bb572af9dfd11127105f1ac99bc958a7cafbb
ToppCellPND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MOXD1 CCDC138 SLC19A2 STIL HELLS

1.09e-0516877508f6e171a1ea5cf65149744296d0fcd6c7b9684e
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL12A1 CCDC138 PTGES STIL HELLS

1.15e-05170775b1a16600754e0c12f7d39c9221f1b03135833f16
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MOXD1 COL12A1 CYP4B1 CYP11A1 SYT1

1.52e-05180775c2746092ef251e9d5910fe96461afdd0624a24c6
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MOXD1 COL12A1 CYP4B1 CYP11A1 SYT1

1.52e-0518077532c6a3886428d82fb4355d987c6d2645f333447b
ToppCellCOPD-Epithelial-ATI|World / Disease state, Lineage and Cell class

CYP4Z2P COL12A1 CYP4B1 AGER SYT1

1.60e-05182775e95d946a43b1579af199900bb0e3eacbb9d65300
ToppCellIPF-Epithelial-ATI|World / Disease state, Lineage and Cell class

CYP4Z2P COL12A1 CYP4B1 AGER SYT1

1.64e-0518377531fef35ecf30162662f24d335d8f0cceacc07039
ToppCellIPF-Epithelial-ATI|IPF / Disease state, Lineage and Cell class

CYP4Z2P COL12A1 CYP4B1 AGER SYT1

1.64e-05183775c0a3541c45bd0c587603521f392f42dd86c3c35b
ToppCellControl-Epithelial-ATI|World / Disease state, Lineage and Cell class

CYP4Z2P COL12A1 CYP4B1 AGER SYT1

1.73e-051857750563d5042bb96ecce8446fbf26d05ef7a45e23c5
ToppCellStriatum-Macroglia-OLIGODENDROCYTE|Striatum / BrainAtlas - Mouse McCarroll V32

DOCK5 ASPA EFCAB3 ITGB4

1.73e-0589774ee1dd3571f5914a8274b71f9ca8b36132ae87fe1
ToppCellCOPD-Epithelial-ATI|COPD / Disease state, Lineage and Cell class

CYP4Z2P COL12A1 CYP4B1 AGER SYT1

1.78e-05186775df0977f6f48a2d4e11b59971f098b01204242f0f
ToppCellControl-Epithelial-ATI|Epithelial / Disease state, Lineage and Cell class

CYP4Z2P COL12A1 CYP4B1 AGER SYT1

1.82e-051877753a032432f780525f4f4c2a358897d9989b1ecae7
ToppCelldroplet-Heart-nan-18m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL12A1 RTTN ASPA SLC19A2 ITGB4

1.92e-051897750493f7b79127c207fd7ade778ef4810500495d7e
ToppCellhuman_hepatoblastoma-Tumor_cells-T1|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

RTTN CCDC138 STIL RFWD3 HELLS

2.12e-051937754b9fa2a4424f8abe63fa7bee78db93dda04ab15f
ToppCellThalamus-Macroglia-OLIGODENDROCYTE-O1-Trf|Thalamus / BrainAtlas - Mouse McCarroll V32

DOCK5 PKD1L1 ASPA ITGB4

4.28e-05112774cb351e57c99aaaf9ae6c7ff7e8ce5375552b1639
ToppCellThalamus-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendrocyte.Trf.Il33_(Il33)|Thalamus / BrainAtlas - Mouse McCarroll V32

DOCK5 PKD1L1 ASPA ITGB4

4.28e-05112774999b5eeed4305e1a1385aadbaf017b64f21c1ee0
ToppCellThalamus-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendrocyte.Trf.Il33_(Il33)-|Thalamus / BrainAtlas - Mouse McCarroll V32

DOCK5 PKD1L1 ASPA ITGB4

4.28e-05112774004cd69b66c3b26b9a61f03279b48230da351574
ToppCellThalamus-Macroglia-OLIGODENDROCYTE-O1|Thalamus / BrainAtlas - Mouse McCarroll V32

DOCK5 PKD1L1 ASPA ITGB4

4.28e-05112774502e3f356f6e1c959bff0a39c98f33f863ce8265
ToppCellThalamus-Macroglia-OLIGODENDROCYTE|Thalamus / BrainAtlas - Mouse McCarroll V32

DOCK5 ASPA ANKIB1 ITGB4

7.42e-05129774b3cb0c10659d1216b8f7de3aa1f9aac101cb65dd
ToppCellE16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-matrix_-_immature_3|E16.5-samps / Age Group, Lineage, Cell class and subclass

NEO1 COL12A1 TCF21 PTGES

1.30e-04149774651494e84be03dc7b061ebdfa91756a1c507b9b4
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1-AT1_Progenitor|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

OMA1 CYP11A1 AGER PTGS1

1.40e-04152774960fa1af2a1499796ac79ccbd884fe2ca14c0ca8
ToppCellTransplant_Alveoli_and_parenchyma-Epithelial-Type_1_alveolar|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

COL12A1 CYP4B1 CYP11A1 AGER

1.70e-0416077458ed3a074932ccc951e07868dfdc61b99ae1cc2b
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Th_Sst|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

MOXD1 EPHX3 PTGS1

1.95e-0465773c336aa3501b9576bf12ef1bbefae55fff7705662
ToppCell356C-Epithelial_cells-Epithelial-D_(AT2)-|356C / Donor, Lineage, Cell class and subclass (all cells)

CYP2J2 CYP4B1 AGER EPHX3

1.96e-041667742e4cb4056e6b0c43290a5588ff525f5f05b8beee
ToppCell356C-Epithelial_cells-Epithelial-D_(AT2)|356C / Donor, Lineage, Cell class and subclass (all cells)

CYP2J2 CYP4B1 AGER EPHX3

1.96e-04166774eb8d972326a734549675307e411fc795af66da70
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

UBE2R2 ACACB SLC19A2 GRN

2.01e-04167774881f64db8dea3faa7588bf04d87c20924a4e5952
ToppCellPND28-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_prolif|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TTC7A OMA1 CCDC138 RFWD3

2.05e-0416877427cdf5cfa1d906868cfd60fdfab3cd51f3b3602f
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TCF21 ASPA PTGES EGFLAM

2.10e-0416977416c52a0f6d96ecc1832922fce9b39691849f0d73
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_104|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MOXD1 TCF21 SYT1 TBL3

2.10e-041697746ff1172da690ca17f7108f1617b255b766971a57
ToppCelldroplet-Lung-1m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-proliferating_NK|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CYP11A1 STIL NCR1 ZNF365

2.30e-04173774c399786aa25bdbe3394988db6955842b5b7e6b41
ToppCellnormal_Lymph_Node-Myeloid_cells-pDCs|Myeloid_cells / Location, Cell class and cell subclass

STIM2 DNAH10 CCDC138 ANKHD1

2.35e-041747742274648b80dd74f3c948a779bba3391095964c34
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MOXD1 TCF21 SYT1 EGFLAM

2.35e-041747749c916af5eebd932f67dc9117e1d26ff194a2ff2c
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MOXD1 TCF21 SYT1 EGFLAM

2.35e-04174774bc71521f44a5fe013af42b06b5d1bd2446ecf3b5
ToppCellControl-Epithelial_cells-AT1|Control / group, cell type (main and fine annotations)

COL12A1 CYP4B1 AGER SYT1

2.35e-04174774548d7f2b958a2bfd2c95eb049ceaab55a559c77d
ToppCellAT1-AT2_cells-Donor_06|World / lung cells shred on cell class, cell subclass, sample id

COL12A1 CYP4B1 CYP11A1 AGER

2.40e-04175774bdd85ba280648a0283c1984662a34c7b840f64dd
ToppCelldroplet-Fat-Bat-18m-Endothelial-endothelial_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACP6 ACACB CYP4B1 EPHX3

2.61e-04179774e6224864eb76a2e9c1fc0c61513d9e936bb5c72c
ToppCelldroplet-Fat-Bat-18m-Endothelial-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACP6 ACACB CYP4B1 EPHX3

2.61e-041797749863ab3ceb160a4b1d9790033a4ac48845863d65
ToppCelldroplet-Fat-Bat-18m-Endothelial|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACP6 ACACB CYP4B1 EPHX3

2.61e-04179774dfe110add7228cd834b35916cbcc849769a01bb9
ToppCellfacs-Lung-24m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

COL12A1 ACACB CYP4B1 ACE

2.67e-04180774baa5825e6ce23a98d9c21d024a4b0ab8ba353d0c
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MOXD1 COL12A1 ASPA ITGB4

2.67e-04180774d9c9399df3e2d9f23dbbfffb6cbe8404bf01e2b7
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Neuronal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MOXD1 COL12A1 ASPA ITGB4

2.67e-04180774dad458398683ff80a6e207bdc08e257d1bb757d6
ToppCellfacs-Lung-24m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

COL12A1 ACACB CYP4B1 ACE

2.67e-041807742d608b9394d28d19cfc85c6ac94003d5177c8a92
ToppCellLPS-IL1RA-Endothelial-Endothelial-Alv_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

EGFLAM CDC25B ACE PTGS1

2.67e-04180774544fb373a3346186ec60afe2cfcf141bb04a1eed
ToppCellLPS-antiTNF-Endothelial-Endothelial-Alv_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

EGFLAM CDC25B ACE PTGS1

2.67e-0418077430cf3c7ee29694eaccb89bf8053a82037d5c9f1d
ToppCellfacs-Lung-24m-Endothelial-arterial_endothelial|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

COL12A1 ACACB CYP4B1 ACE

2.67e-041807740f9b27054358c4737eed06c8ea01987cccc3cb55
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MOXD1 COL12A1 ASPA ITGB4

2.78e-04182774812ff2a50a510b18d865e89465dba1754a08ef61
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT1-AT1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

COL12A1 CYP4B1 AGER SYT1

2.90e-0418477457c792e6e2fedba25d3350ffe649fd74750b579d
ToppCellControl-Neu_4|World / 5 Neutrophil clusters in COVID-19 patients

OMA1 TBC1D9B DNAH10 CLN6

2.90e-04184774ce7f044956613118ee2e9fb6af2455c3166cb414
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1-D122|Adult / Lineage, Cell type, age group and donor

COL12A1 CYP4B1 AGER SYT1

2.90e-04184774561592edc3083fad41b91811151b442207c65dd9
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

COL12A1 CYP4B1 AGER SYT1

2.90e-04184774d7bd0f0c607bade67c99e9fb3578a570298bf926
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1|Children_(3_yrs) / Lineage, Cell type, age group and donor

COL12A1 CYP4B1 AGER SYT1

2.96e-041857741c222f7285d6e3dae0354dc7e853ddc0ea55e63e
ToppCellStriatum-Macroglia-OLIGODENDROCYTE-O2|Striatum / BrainAtlas - Mouse McCarroll V32

ASPA PIWIL4 ITGB4

2.98e-0475773a34bb5997d056727abce1095f762f94b7818c105
ToppCellStriatum-Macroglia-OLIGODENDROCYTE-O2-Trf-Oligodendrocyte.Trf.Klk6_(Klk6)|Striatum / BrainAtlas - Mouse McCarroll V32

ASPA PIWIL4 ITGB4

2.98e-0475773dfc7007f3ecf2b340dbbca519db013c72b3cbbf4
ToppCellStriatum-Macroglia-OLIGODENDROCYTE-O2-Trf|Striatum / BrainAtlas - Mouse McCarroll V32

ASPA PIWIL4 ITGB4

2.98e-04757739501cfd3c5ec820f363e9a52181de34bac725036
ToppCellStriatum-Macroglia-OLIGODENDROCYTE-O2-Trf-Oligodendrocyte.Trf.Klk6_(Klk6)-|Striatum / BrainAtlas - Mouse McCarroll V32

ASPA PIWIL4 ITGB4

2.98e-04757730e25dcbb4194c2f96c9591020f5bddd41542c2b5
ToppCellControl-Endothelial-Endothelial-Vein|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

STIM2 SLC19A2 CLN6 ITGB4

3.02e-0418677492092f11ecce22c14f244e42c499af0822977e6f
ToppCell3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.4.4.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CYP2J2 CYP4B1 PTGES EPHX3

3.09e-0418777482bbc107f58c623f3b90430c90c562624a12abef
ToppCellControl-Epithelial-ATI|Control / Disease state, Lineage and Cell class

CYP4Z2P COL12A1 CYP4B1 AGER

3.09e-04187774fdd1c57b61ca9392ac27661a82729f37593df63c
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

COL12A1 CYP4B1 AGER SYT1

3.09e-04187774d4b0afd9b92c47c8aa348bbd1af7eb54c3d478f2
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.3.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PITRM1 CYP2S1 ITGB4 ZNF365

3.09e-04187774a6a112689d1c9049f57935ad9d2f4955538427de
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1|Adult / Lineage, Cell type, age group and donor

COL12A1 CYP4B1 AGER SYT1

3.09e-0418777477f78aec946bc6bd85c29aee9ca978ce49f853a3
ToppCellP03-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MOXD1 STIM2 ITGB4 PTGS1

3.15e-041887745eb107122064f0a99dfd445cc87d3766f7257216
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DOCK5 COL12A1 CYP4B1 AGER

3.15e-04188774eea652bab161f19148a883e7e3fe2523b36b3cea
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK5 ACACB CYP2J2 ASPA

3.15e-04188774505b6b4277d7dea87aee27191d0acca67928b8e6
ToppCelldroplet-Marrow-nan-3m-Lymphocytic-naive_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFXN1 TBC1D9B TMEM53 HELLS

3.15e-04188774e079a3873cf442e98ff41a240c80b80995aace11
ToppCelldroplet-Heart-HEART-1m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MOXD1 COL12A1 ASPA ITGB4

3.15e-04188774921a2c9212a0f2a00fd72c594d80924f27e8b9b7
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Macroglial|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK5 ACACB CYP2J2 ASPA

3.21e-04189774784ace2be87f2ecb19490f4974f63a559516e0eb
ToppCellCOPD-Epithelial-ATI|Epithelial / Disease state, Lineage and Cell class

COL12A1 CYP4B1 AGER SYT1

3.21e-0418977414e8e57e4db336fbef005270647983b4edf407c0
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK5 ACACB CYP2J2 ASPA

3.21e-0418977437ecbd73408d462b47d7e5611f203143e08a2689
ToppCellNS-critical-d_07-13-Epithelial-FOXN4+|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

RTTN STIL RFWD3 HELLS

3.28e-041907747be0f2ff86ca8500a43e0d44e5e292530f9ba0bb
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MOXD1 COL12A1 TCF21 SYT1

3.28e-041907742306aa9dbeaef3be8484a5b236605de23cd75d4c
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK5 ACACB CYP2J2 ASPA

3.28e-0419077407f21386ea6eb23416a537d2250e3042efe93fb0
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MOXD1 COL12A1 TCF21 SYT1

3.28e-041907741f83f7f24288a3b9ab33c2e113e845dba96adc8a
ToppCelldroplet-Marrow-BM_(NON-STC)-30m-Lymphocytic-naive_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFXN1 TMEM53 PTGS1 HELLS

3.28e-04190774a1b5775a21d42633224b7d348f0d12b0589dad12
ToppCellpdx-Tumor_cells-T1|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

CCDC138 STIL RFWD3 HELLS

3.28e-04190774d06ee5f89f1cec8db6897fe3b2a890a07cd3697b
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MOXD1 COL12A1 TCF21 SYT1

3.34e-04191774a58c75e9580139fb370b498d95660f10f3a2a27b
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK5 MOXD1 COL12A1 SYT1

3.34e-041917741caf726bd07fdca389e678fc16304a6ef1790423
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK5 MOXD1 COL12A1 SYT1

3.34e-041917743d60c46bced2984c27a1fcf2910bc38b31fb0148
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK5 MOXD1 COL12A1 SYT1

3.41e-041927744022f208eb5db760abd0aac782a25e8ab63efc64
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MOXD1 COL12A1 TCF21 SYT1

3.41e-041927749093a9e94a25682d109a7f6edc256a25a61103a0
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MOXD1 COL12A1 TCF21 SYT1

3.41e-041927749ed5d49621ec1aa01716dc369bba1450b5f015f5
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK5 MOXD1 COL12A1 SYT1

3.41e-041927749333aba0d04203ccccad78d82bf6359922f810a7
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MOXD1 COL12A1 CYP4B1 SYT1

3.48e-0419377409a9ab029f01234459a88e3e994fe90ef4cbb8c6
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

MOXD1 NEO1 COL12A1 EGFLAM

3.48e-04193774cd45118ced91b10baed3b1068d4673ec99824b86
ToppCelldroplet-Bladder-nan-24m-Epithelial-bladder_mesenchymal_cell_(Car3+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MOXD1 COL12A1 TCF21 EGFLAM

3.48e-041937742d891c00b8f0aace17d4c300b63e2341dcffa199
ToppCellLAM-LAM-LAM+|LAM / Condition, Lineage and Cell class

MOXD1 TCF21 SYT1 EGFLAM

3.55e-041947744ba73a9145ed44896e359f6df9c1f32bbe24a189
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MOXD1 COL12A1 TCF21 SYT1

3.55e-04194774240d122dcb9dd1ab2867503ad85869853adcacae
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MOXD1 COL12A1 TCF21 SYT1

3.55e-04194774ae7df037592f1c20c9d32be15fe6fc3c562ebeb1
ToppCelldroplet-Limb_Muscle-nan-18m-Mesenchymal-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYP4B1 EGFLAM RIMS2 EPHX3

3.55e-0419477452ecec2618c3bb5fdd7fb06b5a40bd6f0aedfe1d
ToppCellLAM-LAM|LAM / Condition, Lineage and Cell class

MOXD1 TCF21 SYT1 EGFLAM

3.55e-041947744c6561a64711c72c4ef4a3e67c41d2e8d31fba57
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MOXD1 COL12A1 TCF21 SYT1

3.62e-04195774d8ebb94f30d4a655d6b29dd6a3076be2403d2356
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar-AT1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

COL12A1 CYP4B1 AGER SYT1

3.62e-04195774a71ba5e4043e2d35a45a2c60a96b087e31832345
ToppCellfacs-Marrow-B-cells-3m-Lymphocytic-late_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIG4 STIL CDC25B HELLS

3.62e-04195774294c74336fafc1bad237d851efb4a487475078eb
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CYP2J2 PTGES CLN6 RIMS2

3.62e-04195774e7230a849ea31e6eef9bc6f5468938499450582d
ToppCellsevere-Myeloid-Immature_Neutrophils_1|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

SFXN1 ACP6 PTGES GRN

3.62e-04195774becad890a420267ca41e98e61a8da343b51e1945
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MOXD1 COL12A1 TCF21 SYT1

3.62e-0419577444d7bef5f59c2c2bad1392ee6aabdaa5d7f531d9
ToppCelldroplet-Bladder-nan-3m-Epithelial-bladder_mesenchymal_cell_(Car3+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MOXD1 COL12A1 TCF21 EGFLAM

3.62e-04195774095b8e0be385b6390420589124a95fa4ba3682ab
ToppCellfacs-Marrow-B-cells-3m-Lymphocytic-late_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIG4 STIL CDC25B HELLS

3.62e-041957745749ea833be84e262e3d0a4fe1a9a373f0ef545f
ToppCellCOVID-19-Epithelial-Club,_Basal_cells|COVID-19 / Condition, Lineage and Cell class

CYP2J2 CYP4B1 PTGES ITGB4

3.69e-04196774dd32046067d93b9484cfbf1d7826a436a3d9f0e9
ComputationalCytochrome P450.

CYP2J2 CYP4B1 CYP11A1

1.96e-0514423MODULE_106
ComputationalGenes in the cancer module 135.

CYP2J2 CYP4B1 CYP11A1

1.20e-0425423MODULE_135
ComputationalGenes in the cancer module 70.

ACE PTGS1 TBL3

6.14e-0443423MODULE_70
Drughydroxyl radicals

DOCK5 ACP6 CYP2J2 CYP4B1 CYP11A1 AGER ASPA MTR SYT1 SI CYP2S1 USP37 CDC25B ACE EPHX3 F8 PTGS1

1.27e-0613417517CID000000961
Drug5,6-epoxyeicosatrienoic acid

CYP2J2 CYP4B1 MTR CYP2S1 PTGS1

3.00e-0668755CID000001778
DrugAC1L1CJI

CYP2J2 CYP4B1 CYP2S1 ACE

5.26e-0635754CID000001929
Drug11,14,15-THET

CYP2J2 CYP4B1 CYP2S1 PTGS1

8.18e-0639754CID006439531
Drug11,12,15-trihydroxyeicosatrienoic acid

CYP2J2 CYP4B1 CYP2S1 PTGS1

1.11e-0542754CID006439610
Drug19-HETE

CYP2J2 CYP4B1 CYP2S1 PTGS1

2.06e-0549754CID006439528
Drugaminopyrine

CYP2J2 CYP4B1 CYP11A1 CYP2S1 UGT2B28 PTGS1

2.16e-05171756CID000006009
Drugketorolac

TCF21 PTGES PTGS1

3.20e-0519753CID000003826
DiseaseX-24748 measurement

ACP6 CYP4Z2P CYP4B1

9.11e-078763EFO_0022136
DiseaseAlzheimer's disease (implicated_via_orthology)

PITRM1 AGER ACE PTGS1

1.45e-0557764DOID:10652 (implicated_via_orthology)
Diseaserenal fibrosis (is_marker_for)

AGER ACE

3.92e-054762DOID:0050855 (is_marker_for)
DiseaseAdult neuronal ceroid lipofuscinosis

CLN6 GRN

9.75e-056762cv:C0022797
Disease10-undecenoate 11:1n1 measurement

CYP4Z2P CYP4B1

1.36e-047762EFO_0021099
Diseaseproteinuria (is_implicated_in)

AGER ACE

1.36e-047762DOID:576 (is_implicated_in)
DiseaseX-18899 measurement

CYP4Z2P CYP4B1

1.36e-047762EFO_0800793
Diseasepimeloylcarnitine/3-methyladipoylcarnitine (C7-DC) measurement

CYP4Z2P CYP4B1

1.81e-048762EFO_0800494
Diseaserenovascular hypertension (implicated_via_orthology)

ACE PTGS1

2.33e-049762DOID:1591 (implicated_via_orthology)
Diseaseureteral obstruction (implicated_via_orthology)

CYP2J2 ACE

2.33e-049762DOID:5199 (implicated_via_orthology)
Diseasemultiple myeloma (is_implicated_in)

LIG4 MTR ACE

4.81e-0459763DOID:9538 (is_implicated_in)
Diseaseundecenoylcarnitine (C11:1) measurement

CYP4Z2P CYP4B1

5.01e-0413762EFO_0800588
Diseasepre-eclampsia (implicated_via_orthology)

CYP2J2 PTGS1

5.01e-0413762DOID:10591 (implicated_via_orthology)
Diseasetriglycerides in small VLDL measurement

BPTF DNAH10 DOCK7

5.31e-0461763EFO_0022145
Diseasephospholipids in large VLDL measurement

BPTF DNAH10 DOCK7

5.57e-0462763EFO_0022169
Diseasetriglyceride measurement, phospholipid measurement

BPTF ACACB DNAH10 DOCK7

5.60e-04146764EFO_0004530, EFO_0004639
Diseaseidiopathic scoliosis (implicated_via_orthology)

DNAH10 PRMT5

7.67e-0416762DOID:0060250 (implicated_via_orthology)
Diseaserenal fibrosis (implicated_via_orthology)

AGER ACE

8.68e-0417762DOID:0050855 (implicated_via_orthology)
Diseasetriglyceride measurement, low density lipoprotein cholesterol measurement

BPTF ACACB DNAH10 DOCK7

9.04e-04166764EFO_0004530, EFO_0004611
Diseasebipolar disorder (is_marker_for)

GRN PTGS1

1.09e-0319762DOID:3312 (is_marker_for)
DiseasePrimary microcephaly

RTTN STIL

1.46e-0322762C0431350
Diseasenephrosis (biomarker_via_orthology)

CYP11A1 ACE

1.46e-0322762DOID:2527 (biomarker_via_orthology)
Diseasetriglycerides:total lipids ratio, high density lipoprotein cholesterol measurement

BPTF ACACB DNAH10 DOCK7

2.00e-03206764EFO_0004612, EFO_0020947
Diseasemyocardial infarction (is_implicated_in)

CYP2J2 AGER ACE

2.16e-0399763DOID:5844 (is_implicated_in)
Diseaseazoospermia (implicated_via_orthology)

UBE2R2 CDC34

2.20e-0327762DOID:14227 (implicated_via_orthology)
Diseasecoronary artery disease (is_implicated_in)

TCF21 AGER ACE

2.22e-03100763DOID:3393 (is_implicated_in)
Diseasefree cholesterol measurement, very low density lipoprotein cholesterol measurement

BPTF ACACB DNAH10 DOCK7

2.33e-03215764EFO_0008317, EFO_0008591
Diseasevery low density lipoprotein cholesterol measurement, lipid measurement

BPTF ACACB DNAH10 DOCK7

2.54e-03220764EFO_0004529, EFO_0008317
Diseaseamyotrophic lateral sclerosis (is_marker_for)

BPTF GRN

2.54e-0329762DOID:332 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
PLWVGPFTMFFNIHD

CYP4Z2P

81

Q8N1L4
FSIQWKMPRHPGSPI

EGFLAM

51

Q63HQ2
NVFPWIMKFLPGPHQ

CYP2J2

231

P51589
LGLLPVPPEFWNKSM

ACE

931

P12821
QVPWMEKAPAHLSLP

GRN

341

P28799
WFHDMNPQSIALIPP

ANKIB1

976

Q9P2G1
HKMAWPFLEPVDPND

BPTF

2946

Q12830
SPQIHWMKDGVPLPL

AGER

266

Q15109
KMDFSHWPHVLPLEP

RFWD3

621

Q6PCD5
PEMFRQALFKLWGSP

ACACB

1721

O00763
IPGLESMHLWVGFPF

OR52E1

16

Q8NGJ3
PFQQPKHFTGGVMRW

HELLS

211

Q9NRZ9
LPKPFIWAEPHFMVP

NCR1

26

O76036
MEPWKPQHSFFFLLL

IGKV3D-7

1

A0A0C4DH55
EMFSWFLRPLPGPHK

CYP2S1

221

Q96SQ9
PKMLGIFWFHLPEIS

OR52A5

81

Q9H2C5
GFVFKMPWKPTHPSS

CDC25B

196

P30305
HLFNIAKPRPPWMGL

F8

76

P00451
WHPLMPDSFKVGSQE

PTGS1

386

P23219
EPITFAGKMHFVPWL

MRPL37

56

Q9BZE1
AGKMHFVPWLARPIF

MRPL37

61

Q9BZE1
NYIEMKPHPWFFGKI

GRB2

51

P62993
RKIHFNWLPPSGKPM

ITGB4

1141

P16144
HLNVFPAPKKGWNME

DZIP3

476

Q86Y13
LSGPWPKQPMELHNL

OXER1

31

Q8TDS5
ILWIMPAFGARPHFS

OTOP2

506

Q7RTS6
ELSNMVIGWFKLFPP

RIMS2

1366

Q9UQ26
LQWMPFVNIKLHEPF

CCDC138

411

Q96M89
WYNLGPHKIKFIPSM

DOCK5

1091

Q9H7D0
PLPGMKWVDNHKGVF

DOCK7

706

Q96N67
KTKSFVPWQPRFMIH

LIG4

731

P49917
VHMSWAKPVDPIVGY

COL12A1

41

Q99715
HAYHMVKPSPWPLTG

MT-CO3

6

P00414
MFSWFPILFPIKQPI

PRMT5

576

O14744
LMPEKPISFTFWPFN

CYP11A1

501

P05108
NGPLMLFLHGFPENW

EPHX3

96

Q9H6B9
KAMDKFPGPPTHWLF

CYP4B1

41

P13584
PWPPQALHAVAKSFL

DNAH10

2961

Q8IVF4
QRKFQHTGPGMLWSP

EFCAB3

166

Q8N7B9
NPHPLVWAKLKGFPF

ZMYND8

276

Q9ULU4
WFLPMPQKSLFFHHI

SLC19A2

206

O60779
PSPGWFISHVMVKEL

PKD1L1

1871

Q8TDX9
GFPGPWKIQIIFFSM

OR11H7

16

Q8NGC8
ESLMPWKPQLFHLDP

OSBPL5

686

Q9H0X9
LGMAPFHFWVPEVTQ

MT-ND2

106

P03891
FLHLLEWFNFPSVPM

RTTN

46

Q86VV8
KFMNELHKIPLPPWA

SYT1

46

P21579
FLKRFPWMSAPIQVG

SFXN1

256

Q9H9B4
KTLPMTDFQPPLGWH

FER1L5

816

A0AVI2
PWAQDYMHPKLPTLS

FER1L5

1341

A0AVI2
SIPAMELWQPFFPTH

TAF1L

611

Q8IZX4
ELWQPFFPTHMGPIK

TAF1L

616

Q8IZX4
QMDWLSEPHPVKPTF

MTR

941

Q99707
NSKSIMIHWQPPAPA

NEO1

646

Q92859
VKPPWMAFRGEQSKH

PRDM7

101

Q9NQW5
PTFKPWQMKTHFLMP

PITRM1

846

Q5JRX3
EPMEIPQHKLSLWPG

PIWIL4

231

Q7Z3Z4
KQFLWGPAFMVTPVL

SI

1626

P14410
FLGPNPFVAWMHFLV

PTGES

91

O14684
LHGQPKMPEWLSTHP

OMA1

426

Q96E52
PQALPPMLVHGTFWK

TRPT1

121

Q86TN4
WTPFNKLHIPGQMFI

TBC1D9B

311

Q66K14
DWKPLHPGDPMFLTL

ASPA

251

P45381
PGTWAPHIGNMHLKY

ANKHD1

2526

Q8IWZ3
MLVFPLEWFPLNKPS

CLN6

66

Q9NWW5
MVPFHFPPSKCALWN

STIL

21

Q15468
SPPAFRFLTKMWHPN

CDC34

71

P49427
AGLWVSLFHTIPPGM

MOXD1

341

Q6UVY6
VVLFGPLTRPPHNWM

STIM2

201

Q9P246
PLTRPPHNWMKDFIL

STIM2

206

Q9P246
HNMKLPVPAAAPTPW

TBL3

786

Q12788
PWHMVFFSESLGIPS

TMEM53

71

Q6P2H8
MEKPLFPLVPLHWFG

TMEM14DP

1

A8MWL7
HPVNLTWPFMVAGKP

TCF21

146

O43680
LLMTLGIFDHKWPPF

ACP6

341

Q9NPH0
MEKPLFPLVPLHWFG

TMEM14B

1

Q9NUH8
IPVLTWFFPIIGHMG

TMEM222

61

Q9H0R3
ENTKPPFTLGWSAHM

USP37

596

Q86T82
WSPLSHPLPEFMGKE

TTC7A

301

Q9ULT0
PNGLPNHIMAPVWKC

GTF3C2

296

Q8WUA4
MKQAPPWKDHLTFQP

ZNF365

51

Q70YC4
SPPTFRFLTKMWHPN

UBE2R2

71

Q712K3
HGIPMVGIPLFWDQP

UGT2B28

386

Q9BY64
PPNHRKGILCMFPWQ

PRO1933

41

Q9H354
EHMAQQDPGLPFLFW

KIAA2013

581

Q8IYS2