Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR8H3 UTS2R OR4N2 HTR6 OR10P1 ESR1 OR5AN1 OR5B17 TAAR3P OR14I1 OR6C65 TAAR8 OR13J1 OR14A16 OR2AJ1 OR51A7 GPR149 OR6C75 OR52E8 OR52E6 HRH4 OR51V1 OR5AP2	2.28e-10	884	107	23	GO:0004930
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR8H3 UTS2R OR4N2 HTR6 OR10P1 ESR1 OR5AN1 OR5B17 TAAR3P OR14I1 OR6C65 TAAR8 OR13J1 OR14A16 CHRNA5 CHRNB2 OR2AJ1 OR51A7 MS4A2 P2RX3 EDAR GPR149 OR6C75 OR52E8 OR52E6 HRH4 OR51V1 OR5AP2	3.43e-10	1353	107	28	GO:0004888
GeneOntologyMolecularFunction	olfactory receptor activity	OR8H3 OR4N2 OR10P1 OR5AN1 OR5B17 OR14I1 OR6C65 OR13J1 OR14A16 OR2AJ1 OR51A7 OR6C75 OR52E8 OR52E6 OR51V1 OR5AP2	1.21e-09	431	107	16	GO:0004984
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	CACNA1B CACNA1C PKD1L2 SLC30A1 CHRNA5 CHRNB2 SLC9A4 SLC9A3 TRPM5 SLC25A12 P2RX3 NALCN KCND1 KCND3 SLC10A6 SLC4A10 CACNA1H TMCO1 SCN3B	2.24e-09	664	107	19	GO:0008324
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	CACNA1B CACNA1C PKD1L2 SLC30A1 SLC9A4 SLC9A3 TRPM5 NALCN KCND1 KCND3 SLC10A6 SLC4A10 CACNA1H TMCO1 SCN3B	2.72e-08	465	107	15	GO:0046873
GeneOntologyMolecularFunction	monoatomic cation channel activity	CACNA1B CACNA1C PKD1L2 CHRNA5 CHRNB2 TRPM5 P2RX3 NALCN KCND1 KCND3 CACNA1H TMCO1 SCN3B	3.83e-08	343	107	13	GO:0005261
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	CACNA1B CACNA1C PKD1L2 SLC30A1 CHRNA5 CHRNB2 SLC9A4 SLC9A3 TRPM5 SLC25A12 P2RX3 NALCN KCND1 KCND3 SLC10A6 SLC4A10 CACNA1H TMCO1 SCN3B	3.92e-08	793	107	19	GO:0015075
GeneOntologyMolecularFunction	transmembrane transporter activity	CACNA1B CACNA1C ABCA4 GJB6 PKD1L2 SLC30A1 CHRNA5 CHRNB2 SLC9A4 SLC9A3 TRPM5 SLC25A12 P2RX3 NALCN KCND1 KCND3 SLC10A6 SLC4A10 CACNA1H TMCO1 SLC16A7 DISP1 SCN3B	5.40e-08	1180	107	23	GO:0022857
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	CACNA1B CACNA1C PKD1L2 SLC30A1 SLC9A4 SLC9A3 TRPM5 SLC25A12 NALCN KCND1 KCND3 SLC10A6 SLC4A10 CACNA1H TMCO1 SCN3B	2.26e-07	627	107	16	GO:0022890
GeneOntologyMolecularFunction	transporter activity	CACNA1B CACNA1C ABCA4 GJB6 PKD1L2 SLC30A1 CHRNA5 CHRNB2 SLC9A4 SLC9A3 TRPM5 SLC25A12 P2RX3 NALCN KCND1 KCND3 SLC10A6 SLC4A10 CACNA1H TMCO1 SLC16A7 DISP1 SCN3B	2.64e-07	1289	107	23	GO:0005215
GeneOntologyMolecularFunction	channel activity	CACNA1B CACNA1C GJB6 PKD1L2 CHRNA5 CHRNB2 TRPM5 P2RX3 NALCN KCND1 KCND3 CACNA1H TMCO1 SCN3B	8.22e-07	525	107	14	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	CACNA1B CACNA1C GJB6 PKD1L2 CHRNA5 CHRNB2 TRPM5 P2RX3 NALCN KCND1 KCND3 CACNA1H TMCO1 SCN3B	8.41e-07	526	107	14	GO:0022803
GeneOntologyMolecularFunction	monoatomic ion channel activity	CACNA1B CACNA1C PKD1L2 CHRNA5 CHRNB2 TRPM5 P2RX3 NALCN KCND1 KCND3 CACNA1H TMCO1 SCN3B	1.07e-06	459	107	13	GO:0005216
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	CACNA1B CACNA1C PKD1L2 SLC30A1 SLC9A4 SLC9A3 TRPM5 SLC25A12 NALCN KCND1 KCND3 SLC10A6 SLC4A10 CACNA1H TMCO1 SCN3B	2.74e-06	758	107	16	GO:0015318
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SLC9A4 SLC9A3 TRPM5 NALCN SLC10A6 SLC4A10 CACNA1H SCN3B	3.89e-06	171	107	8	GO:0015081
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1B CACNA1C CACNA1H	5.22e-05	14	107	3	GO:0008331
GeneOntologyMolecularFunction	odorant binding	OR8H3 OR5AN1 OR5B17 OR14I1 OR14A16 OR5AP2	6.29e-05	127	107	6	GO:0005549
GeneOntologyMolecularFunction	G protein-coupled amine receptor activity	HTR6 TAAR3P TAAR8 HRH4	6.77e-05	41	107	4	GO:0008227
GeneOntologyMolecularFunction	calcium channel activity	CACNA1B CACNA1C PKD1L2 TRPM5 CACNA1H TMCO1	6.86e-05	129	107	6	GO:0005262
GeneOntologyMolecularFunction	gated channel activity	CACNA1B CACNA1C CHRNA5 CHRNB2 TRPM5 P2RX3 KCND1 KCND3 CACNA1H	7.84e-05	334	107	9	GO:0022836
GeneOntologyMolecularFunction	metal cation:monoatomic cation antiporter activity	SLC30A1 SLC9A4 SLC9A3 SLC4A10	8.19e-05	43	107	4	GO:0140828
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	CACNA1B CACNA1C PKD1L2 TRPM5 CACNA1H TMCO1	1.63e-04	151	107	6	GO:0015085
GeneOntologyMolecularFunction	A-type (transient outward) potassium channel activity	KCND1 KCND3	1.69e-04	4	107	2	GO:0005250
GeneOntologyMolecularFunction	sodium channel activity	TRPM5 NALCN CACNA1H SCN3B	1.73e-04	52	107	4	GO:0005272
GeneOntologyMolecularFunction	acetylcholine receptor activity	CHRNA5 CHRNB2 HRH4	2.45e-04	23	107	3	GO:0015464
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	NALCN CACNA1H SCN3B	3.56e-04	26	107	3	GO:0005248
GeneOntologyMolecularFunction	metal cation:proton antiporter activity	SLC30A1 SLC9A4 SLC9A3	3.98e-04	27	107	3	GO:0051139
GeneOntologyMolecularFunction	histamine receptor activity	HTR6 HRH4	4.21e-04	6	107	2	GO:0004969
GeneOntologyMolecularFunction	trace-amine receptor activity	TAAR3P TAAR8	7.80e-04	8	107	2	GO:0001594
GeneOntologyMolecularFunction	antiporter activity	SLC30A1 SLC9A4 SLC9A3 SLC25A12 SLC4A10	8.86e-04	138	107	5	GO:0015297
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC30A1 SLC9A4 SLC9A3 SLC25A12 SLC10A6 SLC4A10 SLC16A7	1.08e-03	296	107	7	GO:0015291
GeneOntologyMolecularFunction	voltage-gated monoatomic cation channel activity	CACNA1B CACNA1C KCND1 KCND3 CACNA1H	1.36e-03	152	107	5	GO:0022843
GeneOntologyMolecularFunction	excitatory extracellular ligand-gated monoatomic ion channel activity	CHRNA5 CHRNB2 P2RX3	1.58e-03	43	107	3	GO:0005231
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	CACNA1B CACNA1C CACNA1H	1.92e-03	46	107	3	GO:0005245
GeneOntologyMolecularFunction	neurotransmitter receptor activity	HTR6 CHRNA5 CHRNB2 HRH4	2.06e-03	100	107	4	GO:0030594
GeneOntologyMolecularFunction	potassium ion transmembrane transporter activity	SLC9A4 SLC9A3 TRPM5 KCND1 KCND3	2.06e-03	167	107	5	GO:0015079
GeneOntologyMolecularFunction	acetylcholine binding	CHRNA5 CHRNB2	2.13e-03	13	107	2	GO:0042166
GeneOntologyMolecularFunction	potassium:proton antiporter activity	SLC9A4 SLC9A3	2.48e-03	14	107	2	GO:0015386
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	CACNA1B CACNA1C KCND1 KCND3 CACNA1H	2.99e-03	182	107	5	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	CACNA1B CACNA1C KCND1 KCND3 CACNA1H	3.14e-03	184	107	5	GO:0022832
GeneOntologyMolecularFunction	sodium:proton antiporter activity	SLC9A4 SLC9A3	3.25e-03	16	107	2	GO:0015385
GeneOntologyMolecularFunction	acetylcholine-gated monoatomic cation-selective channel activity	CHRNA5 CHRNB2	3.67e-03	17	107	2	GO:0022848
GeneOntologyMolecularFunction	active transmembrane transporter activity	ABCA4 SLC30A1 SLC9A4 SLC9A3 SLC25A12 SLC10A6 SLC4A10 SLC16A7	4.15e-03	477	107	8	GO:0022804
GeneOntologyMolecularFunction	secondary active monocarboxylate transmembrane transporter activity	SLC10A6 SLC16A7	4.58e-03	19	107	2	GO:0015355
GeneOntologyMolecularFunction	solute:potassium antiporter activity	SLC9A4 SLC9A3	4.58e-03	19	107	2	GO:0022821
GeneOntologyMolecularFunction	active monoatomic ion transmembrane transporter activity	SLC30A1 SLC9A4 SLC9A3 SLC25A12 SLC10A6 SLC4A10	5.66e-03	301	107	6	GO:0022853
GeneOntologyMolecularFunction	G protein-coupled serotonin receptor activity	HTR6 HRH4	6.13e-03	22	107	2	GO:0004993
GeneOntologyMolecularFunction	organic hydroxy compound transmembrane transporter activity	ABCA4 SLC10A6 SLC16A7	6.31e-03	70	107	3	GO:1901618
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR8H3 OR4N2 OR10P1 OR5AN1 OR5B17 TAAR3P OR14I1 OR6C65 OR13J1 OR14A16 OR2AJ1 OR51A7 P2RX3 OR6C75 OR52E8 OR52E6 OR51V1 OR5AP2	4.16e-10	547	107	18	GO:0007606
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR8H3 OR4N2 OR10P1 OR5AN1 OR5B17 OR14I1 OR6C65 OR13J1 OR14A16 OR2AJ1 OR51A7 OR6C75 OR52E8 OR52E6 OR51V1 OR5AP2	7.90e-10	432	107	16	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of smell	OR8H3 OR4N2 OR10P1 OR5AN1 OR5B17 OR14I1 OR6C65 OR13J1 OR14A16 OR2AJ1 OR51A7 OR6C75 OR52E8 OR52E6 OR51V1 OR5AP2	2.28e-09	465	107	16	GO:0007608
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR8H3 OR4N2 OR10P1 OR5AN1 OR5B17 OR14I1 OR6C65 OR13J1 OR14A16 OR2AJ1 OR51A7 OR6C75 OR52E8 OR52E6 OR51V1 OR5AP2	4.15e-09	485	107	16	GO:0050907
GeneOntologyBiologicalProcess	sensory perception	OR8H3 ABCA4 OR4N2 OR10P1 GJB6 OR5AN1 OR5B17 TAAR3P OR14I1 OR6C65 OR13J1 OR14A16 CHRNA5 CHRNB2 OR2AJ1 OR51A7 P2RX3 OR6C75 OR52E8 OR52E6 SLC4A10 OR51V1 OR5AP2	5.01e-09	1072	107	23	GO:0007600
GeneOntologyBiologicalProcess	detection of stimulus	OR8H3 ABCA4 OR4N2 OR10P1 OR5AN1 OR5B17 OR14I1 OR6C65 PKD1L2 OR13J1 OR14A16 CHRNA5 OR2AJ1 OR51A7 OR6C75 OR52E8 OR52E6 OR51V1 OR5AP2	5.21e-09	722	107	19	GO:0051606
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR8H3 UTS2R OR4N2 HTR6 OR10P1 ESR1 OR5AN1 OR5B17 TAAR3P OR14I1 OR6C65 VPS54 TAAR8 OR13J1 OR14A16 ADCY9 OR2AJ1 OR51A7 MS4A2 GPR149 OR6C75 OR52E8 OR52E6 HRH4 OR51V1 OR5AP2	7.73e-09	1395	107	26	GO:0007186
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR8H3 OR4N2 OR10P1 OR5AN1 OR5B17 OR14I1 OR6C65 OR13J1 OR14A16 CHRNA5 OR2AJ1 OR51A7 OR6C75 OR52E8 OR52E6 OR51V1 OR5AP2	7.97e-09	582	107	17	GO:0050906
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR8H3 OR4N2 OR10P1 OR5AN1 OR5B17 OR14I1 OR6C65 OR13J1 OR14A16 OR2AJ1 OR51A7 OR6C75 OR52E8 OR52E6 OR51V1 OR5AP2	1.24e-08	524	107	16	GO:0009593
GeneOntologyBiologicalProcess	metal ion transport	CACNA1B CACNA1C PKD1L2 SLC30A1 CHRNB2 SLC9A4 SLC9A3 TRPM5 MS4A2 P2RX3 NALCN KCND1 KCND3 HECW2 SLC10A6 SLC4A10 CACNA1H TMCO1 SCN3B	8.48e-07	1000	107	19	GO:0030001
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	CACNA1B CACNA1C PKD1L2 SLC30A1 CHRNA5 CHRNB2 SLC9A4 SLC9A3 TRPM5 SLC25A12 MS4A2 P2RX3 NALCN KCND1 KCND3 HECW2 SLC4A10 CACNA1H TMCO1 SCN3B	1.03e-06	1115	107	20	GO:0034220
GeneOntologyBiologicalProcess	inorganic cation transmembrane transport	CACNA1B CACNA1C PKD1L2 SLC30A1 SLC9A4 SLC9A3 TRPM5 SLC25A12 MS4A2 P2RX3 NALCN KCND1 KCND3 HECW2 SLC4A10 CACNA1H TMCO1 SCN3B	1.17e-06	922	107	18	GO:0098662
GeneOntologyBiologicalProcess	monoatomic cation transmembrane transport	CACNA1B CACNA1C PKD1L2 SLC30A1 SLC9A4 SLC9A3 TRPM5 SLC25A12 MS4A2 P2RX3 NALCN KCND1 KCND3 HECW2 SLC4A10 CACNA1H TMCO1 SCN3B	1.58e-06	942	107	18	GO:0098655
GeneOntologyBiologicalProcess	monoatomic ion transport	CACNA1B CACNA1C PKD1L2 SLC30A1 CLDN10 CHRNA5 CHRNB2 SLC9A4 SLC9A3 TRPM5 SLC25A12 MS4A2 P2RX3 NALCN KCND1 KCND3 HECW2 SLC10A6 SLC4A10 CACNA1H TMCO1 SCN3B	1.80e-06	1374	107	22	GO:0006811
GeneOntologyBiologicalProcess	monoatomic cation transport	CACNA1B CACNA1C PKD1L2 SLC30A1 CHRNB2 SLC9A4 SLC9A3 TRPM5 SLC25A12 MS4A2 P2RX3 NALCN KCND1 KCND3 HECW2 SLC10A6 SLC4A10 CACNA1H TMCO1 SCN3B	1.81e-06	1157	107	20	GO:0006812
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	CACNA1B CACNA1C PKD1L2 SLC30A1 SLC9A4 SLC9A3 TRPM5 SLC25A12 MS4A2 P2RX3 NALCN KCND1 KCND3 HECW2 SLC4A10 CACNA1H TMCO1 SCN3B	4.64e-06	1017	107	18	GO:0098660
GeneOntologyBiologicalProcess	inorganic ion import across plasma membrane	CACNA1B CACNA1C SLC30A1 SLC9A4 SLC9A3 KCND3 CACNA1H	9.28e-06	142	107	7	GO:0099587
GeneOntologyBiologicalProcess	inorganic cation import across plasma membrane	CACNA1B CACNA1C SLC30A1 SLC9A4 SLC9A3 KCND3 CACNA1H	9.28e-06	142	107	7	GO:0098659
GeneOntologyBiologicalProcess	action potential	CACNA1C CHRNA5 CHRNB2 P2RX3 KCND1 KCND3 CACNA1H SCN3B	1.01e-05	201	107	8	GO:0001508
GeneOntologyBiologicalProcess	sodium ion transmembrane transport	SLC9A4 SLC9A3 TRPM5 NALCN HECW2 SLC4A10 CACNA1H SCN3B	1.30e-05	208	107	8	GO:0035725
GeneOntologyBiologicalProcess	sodium ion transport	SLC9A4 SLC9A3 TRPM5 NALCN HECW2 SLC10A6 SLC4A10 CACNA1H SCN3B	1.34e-05	275	107	9	GO:0006814
GeneOntologyBiologicalProcess	calcium ion transport	CACNA1B CACNA1C PKD1L2 SLC30A1 CHRNB2 TRPM5 MS4A2 P2RX3 NALCN CACNA1H TMCO1	6.80e-05	509	107	11	GO:0006816
GeneOntologyBiologicalProcess	synaptic transmission, cholinergic	HTR6 CHRNA5 CHRNB2 NALCN	7.92e-05	44	107	4	GO:0007271
GeneOntologyBiologicalProcess	import across plasma membrane	CACNA1B CACNA1C SLC30A1 SLC9A4 SLC9A3 KCND3 CACNA1H	1.98e-04	230	107	7	GO:0098739
GeneOntologyBiologicalProcess	calcium ion transmembrane transport	CACNA1B CACNA1C PKD1L2 TRPM5 MS4A2 P2RX3 NALCN CACNA1H TMCO1	2.05e-04	392	107	9	GO:0070588
GeneOntologyBiologicalProcess	neuronal action potential	CHRNA5 CHRNB2 P2RX3 CACNA1H	3.22e-04	63	107	4	GO:0019228
GeneOntologyBiologicalProcess	regulation of branching involved in prostate gland morphogenesis	ESR1 BMP7	3.95e-04	6	107	2	GO:0060687
GeneOntologyBiologicalProcess	membrane depolarization	CACNA1C CHRNA5 CHRNB2 CACNA1H SCN3B	4.22e-04	121	107	5	GO:0051899
GeneOntologyBiologicalProcess	postsynaptic signal transduction	CHRNA5 CHRNB2 HRH4 KPNA1	4.57e-04	69	107	4	GO:0098926
GeneOntologyCellularComponent	monoatomic ion channel complex	CACNA1B CACNA1C CHRNA5 CHRNB2 TRPM5 NALCN KCND1 KCND3 CACNA1H SCN3B	2.46e-05	378	107	10	GO:0034702
GeneOntologyCellularComponent	transporter complex	CACNA1B CACNA1C ERGIC2 CHRNA5 CHRNB2 TRPM5 NALCN KCND1 KCND3 CACNA1H SCN3B	1.20e-04	550	107	11	GO:1990351
GeneOntologyCellularComponent	dendrite	CACNA1B CACNA1C HTR6 SLC30A1 CHRNA5 ADCY9 TRPM5 P2RX3 KCND1 KCND3 SLC4A10 HRH4 CACNA1H KPNA1	1.22e-04	858	107	14	GO:0030425
GeneOntologyCellularComponent	dendritic tree	CACNA1B CACNA1C HTR6 SLC30A1 CHRNA5 ADCY9 TRPM5 P2RX3 KCND1 KCND3 SLC4A10 HRH4 CACNA1H KPNA1	1.25e-04	860	107	14	GO:0097447
GeneOntologyCellularComponent	postsynaptic membrane	CACNA1C NBEA SLC30A1 CHRNA5 CHRNB2 KCND1 KCND3 CACNA1H SLC16A7	2.37e-04	405	107	9	GO:0045211
GeneOntologyCellularComponent	transmembrane transporter complex	CACNA1B CACNA1C CHRNA5 CHRNB2 TRPM5 NALCN KCND1 KCND3 CACNA1H SCN3B	3.54e-04	523	107	10	GO:1902495
GeneOntologyCellularComponent	somatodendritic compartment	CACNA1B CACNA1C HTR6 MYO10 ESR1 SLC30A1 CHRNA5 ADCY9 TRPM5 P2RX3 KCND1 KCND3 SLC4A10 HRH4 CACNA1H KPNA1	5.03e-04	1228	107	16	GO:0036477
GeneOntologyCellularComponent	synaptic membrane	CACNA1C NBEA SLC30A1 CHRNA5 CHRNB2 P2RX3 KCND1 KCND3 CACNA1H SLC16A7	8.20e-04	583	107	10	GO:0097060
GeneOntologyCellularComponent	plasma membrane raft	CACNA1C ASAH2 CHRNB2 KCND3 CACNA1H	9.60e-04	147	107	5	GO:0044853
GeneOntologyCellularComponent	cation channel complex	CACNA1B CACNA1C KCND1 KCND3 CACNA1H SCN3B	1.33e-03	235	107	6	GO:0034703
GeneOntologyCellularComponent	nucleocytoplasmic transport complex	XPO5 KPNA1	1.66e-03	12	107	2	GO:0031074
GeneOntologyCellularComponent	voltage-gated calcium channel complex	CACNA1B CACNA1C CACNA1H	1.69e-03	46	107	3	GO:0005891
GeneOntologyCellularComponent	postsynapse	DOCK1 CACNA1C NBEA SLC30A1 CHRNA5 CHRNB2 P2RX3 KCND1 KCND3 SLC4A10 CACNA1H SLC16A7 KPNA1	2.09e-03	1018	107	13	GO:0098794
GeneOntologyCellularComponent	plasma membrane protein complex	CACNA1B CACNA1C GJB6 CHRNA5 CHRNB2 NOX1 MS4A2 KCND1 KCND3 CACNA1H SCN3B	2.29e-03	785	107	11	GO:0098797
Domain	7tm_1	OR8H3 UTS2R OR4N2 HTR6 OR10P1 OR5AN1 OR5B17 TAAR3P OR14I1 OR6C65 TAAR8 OR13J1 OR14A16 OR2AJ1 OR51A7 GPR149 OR6C75 OR52E8 OR52E6 HRH4 OR51V1 OR5AP2	2.07e-11	677	105	22	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR8H3 UTS2R OR4N2 HTR6 OR10P1 OR5AN1 OR5B17 TAAR3P OR14I1 OR6C65 TAAR8 OR13J1 OR14A16 OR2AJ1 OR51A7 GPR149 OR6C75 OR52E8 OR52E6 HRH4 OR51V1 OR5AP2	2.60e-11	685	105	22	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR8H3 UTS2R OR4N2 HTR6 OR10P1 OR5AN1 OR5B17 TAAR3P OR14I1 OR6C65 TAAR8 OR13J1 OR14A16 OR2AJ1 OR51A7 GPR149 OR6C75 OR52E8 OR52E6 HRH4 OR51V1 OR5AP2	3.08e-11	691	105	22	PS50262
Domain	GPCR_Rhodpsn	OR8H3 UTS2R OR4N2 HTR6 OR10P1 OR5AN1 OR5B17 TAAR3P OR14I1 OR6C65 TAAR8 OR13J1 OR14A16 OR2AJ1 OR51A7 GPR149 OR6C75 OR52E8 OR52E6 HRH4 OR51V1 OR5AP2	3.17e-11	692	105	22	IPR000276
Domain	Olfact_rcpt	OR8H3 OR4N2 OR10P1 OR5AN1 OR5B17 OR14I1 OR6C65 OR13J1 OR14A16 OR2AJ1 OR51A7 OR6C75 OR52E8 OR52E6 OR51V1 OR5AP2	6.20e-10	393	105	16	IPR000725
Domain	GPCR_Rhodpsn_7TM	OR8H3 UTS2R OR4N2 HTR6 OR10P1 OR5AN1 OR5B17 OR14I1 OR6C65 TAAR8 OR13J1 OR14A16 OR51A7 GPR149 OR6C75 OR52E8 OR52E6 HRH4 OR51V1 OR5AP2	8.50e-10	670	105	20	IPR017452
Domain	Channel_four-helix_dom	CACNA1B CACNA1C NALCN KCND1 KCND3 CACNA1H	7.86e-07	57	105	6	IPR027359
Domain	-	CACNA1B CACNA1C NALCN KCND1 KCND3 CACNA1H	7.86e-07	57	105	6	1.20.120.350
Domain	Ion_trans_dom	CACNA1B CACNA1C TRPM5 NALCN KCND1 KCND3 CACNA1H	3.64e-06	114	105	7	IPR005821
Domain	Ion_trans	CACNA1B CACNA1C TRPM5 NALCN KCND1 KCND3 CACNA1H	3.64e-06	114	105	7	PF00520
Domain	VDCCAlpha1	CACNA1B CACNA1C CACNA1H	2.01e-05	10	105	3	IPR002077
Domain	TMEM183	TMEM183A TMEM183BP	3.13e-05	2	105	2	IPR026509
Domain	DUF1088	NBEA LRBA	3.13e-05	2	105	2	IPR010508
Domain	DUF1088	NBEA LRBA	3.13e-05	2	105	2	PF06469
Domain	DUF3399	KCND1 KCND3	9.36e-05	3	105	2	PF11879
Domain	K_chnl_volt-dep_Kv4	KCND1 KCND3	9.36e-05	3	105	2	IPR003975
Domain	Shal-type	KCND1 KCND3	9.36e-05	3	105	2	PF11601
Domain	Shal-type_N	KCND1 KCND3	9.36e-05	3	105	2	IPR021645
Domain	K_chnl_volt-dep_Kv4_C	KCND1 KCND3	9.36e-05	3	105	2	IPR024587
Domain	DOCK_N	DOCK1 DOCK2	3.10e-04	5	105	2	PF16172
Domain	DOCK_N	DOCK1 DOCK2	3.10e-04	5	105	2	IPR032376
Domain	DUF4704	NBEA LRBA	3.10e-04	5	105	2	IPR031570
Domain	DUF4704	NBEA LRBA	3.10e-04	5	105	2	PF15787
Domain	PH_BEACH	NBEA LRBA	4.63e-04	6	105	2	PF14844
Domain	VDCC_a1su_IQ	CACNA1B CACNA1C	6.45e-04	7	105	2	IPR014873
Domain	TAAR_fam	TAAR3P TAAR8	6.45e-04	7	105	2	IPR009132
Domain	GPHH	CACNA1B CACNA1C	6.45e-04	7	105	2	PF16905
Domain	GPHH_dom	CACNA1B CACNA1C	6.45e-04	7	105	2	IPR031649
Domain	Ca_chan_IQ	CACNA1B CACNA1C	6.45e-04	7	105	2	SM01062
Domain	Ca_chan_IQ	CACNA1B CACNA1C	6.45e-04	7	105	2	PF08763
Domain	PH-BEACH_dom	NBEA LRBA	8.57e-04	8	105	2	IPR023362
Domain	-	NBEA LRBA	8.57e-04	8	105	2	2.30.29.40
Domain	PH_BEACH	NBEA LRBA	8.57e-04	8	105	2	PS51783
Domain	NaH_exchanger	SLC9A4 SLC9A3	1.10e-03	9	105	2	IPR004709
Domain	BEACH_dom	NBEA LRBA	1.10e-03	9	105	2	IPR000409
Domain	BEACH	NBEA LRBA	1.10e-03	9	105	2	PS50197
Domain	Beach	NBEA LRBA	1.10e-03	9	105	2	PF02138
Domain	-	NBEA LRBA	1.10e-03	9	105	2	1.10.1540.10
Domain	Ptc/Disp	PTCHD1 DISP1	1.10e-03	9	105	2	IPR003392
Domain	Patched	PTCHD1 DISP1	1.10e-03	9	105	2	PF02460
Domain	Beach	NBEA LRBA	1.10e-03	9	105	2	SM01026
Domain	DOCK_C	DOCK1 DOCK2	1.67e-03	11	105	2	IPR010703
Domain	Cation/H_exchanger_CPA1	SLC9A4 SLC9A3	1.67e-03	11	105	2	IPR018422
Domain	DHR-1_domain	DOCK1 DOCK2	1.67e-03	11	105	2	IPR027007
Domain	DHR_2	DOCK1 DOCK2	1.67e-03	11	105	2	PS51651
Domain	DHR_1	DOCK1 DOCK2	1.67e-03	11	105	2	PS51650
Domain	DOCK-C2	DOCK1 DOCK2	1.67e-03	11	105	2	PF14429
Domain	DHR-2	DOCK1 DOCK2	1.67e-03	11	105	2	IPR027357
Domain	DHR-2	DOCK1 DOCK2	1.67e-03	11	105	2	PF06920
Domain	DOCK	DOCK1 DOCK2	1.67e-03	11	105	2	IPR026791
Domain	SSD	PTCHD1 DISP1	2.35e-03	13	105	2	IPR000731
Domain	SSD	PTCHD1 DISP1	2.35e-03	13	105	2	PS50156
Domain	FERM_central	MYO10 JAK1 NF2	2.64e-03	49	105	3	IPR019748
Domain	FERM_domain	MYO10 JAK1 NF2	2.64e-03	49	105	3	IPR000299
Domain	Na_H_Exchanger	SLC9A4 SLC9A3	2.73e-03	14	105	2	PF00999
Domain	Cation/H_exchanger	SLC9A4 SLC9A3	2.73e-03	14	105	2	IPR006153
Domain	FERM_1	MYO10 JAK1 NF2	2.79e-03	50	105	3	PS00660
Domain	FERM_2	MYO10 JAK1 NF2	2.79e-03	50	105	3	PS00661
Domain	FERM_3	MYO10 JAK1 NF2	2.79e-03	50	105	3	PS50057
Domain	Band_41_domain	MYO10 JAK1 NF2	2.79e-03	50	105	3	IPR019749
Domain	B41	MYO10 JAK1 NF2	2.79e-03	50	105	3	SM00295
Domain	ARM-type_fold	DOCK1 DOCK2 NBEA URB1 XPO5 LRBA KPNA1	3.04e-03	339	105	7	IPR016024
Domain	Nicotinic_acetylcholine_rcpt	CHRNA5 CHRNB2	3.57e-03	16	105	2	IPR002394
Domain	Fd_Rdtase_FAD-bd	POR NOX1	5.03e-03	19	105	2	IPR017927
Domain	FAD_FR	POR NOX1	5.03e-03	19	105	2	PS51384
Domain	Riboflavin_synthase-like_b-brl	POR NOX1	5.03e-03	19	105	2	IPR017938
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR8H3 OR4N2 OR10P1 OR5AN1 OR5B17 OR14I1 OR6C65 OR13J1 OR14A16 OR2AJ1 OR51A7 OR6C75 OR52E8 OR52E6 OR51V1 OR5AP2	6.31e-09	417	89	16	M4072
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR8H3 OR4N2 OR10P1 OR5AN1 OR5B17 OR14I1 OR6C65 OR13J1 OR14A16 OR51A7 OR6C75 OR52E8 OR52E6 OR51V1 OR5AP2	1.86e-08	389	89	15	M14091
Pathway	REACTOME_SENSORY_PERCEPTION	OR8H3 ABCA4 OR4N2 OR10P1 OR5AN1 OR5B17 OR14I1 OR6C65 OR13J1 OR14A16 OR2AJ1 OR51A7 TRPM5 OR6C75 OR52E8 OR52E6 OR51V1 OR5AP2	7.12e-08	636	89	18	M41834
Pathway	REACTOME_AMINE_LIGAND_BINDING_RECEPTORS	HTR6 TAAR3P TAAR8 HRH4	1.38e-04	42	89	4	MM14971
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR8H3 OR4N2 OR10P1 OR5AN1 OR6C65 OR13J1 OR2AJ1 OR51A7 OR6C75 OR52E8 OR51V1 OR5AP2	6.78e-10	340	107	12	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR8H3 OR4N2 OR10P1 OR5AN1 OR6C65 OR13J1 OR2AJ1 OR51A7 OR6C75 OR52E8 OR51V1 OR5AP2	6.78e-10	340	107	12	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR8H3 OR4N2 OR10P1 OR5AN1 OR6C65 OR13J1 OR2AJ1 OR51A7 OR6C75 OR52E8 OR51V1 OR5AP2	7.49e-10	343	107	12	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR8H3 OR4N2 OR10P1 OR5AN1 OR6C65 OR13J1 OR2AJ1 OR51A7 OR6C75 OR52E8 OR51V1 OR5AP2	8.27e-10	346	107	12	14611657
Pubmed	The human olfactory receptor gene family.	OR8H3 OR4N2 OR10P1 OR5AN1 OR5B17 OR13J1 OR14A16 OR2AJ1 OR51A7 OR52E8 OR52E6 OR51V1	1.15e-07	541	107	12	14983052
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	CACNA1B CACNA1C P2RX3 KCND1 KCND3 CACNA1H SCN3B	2.61e-07	139	107	7	16985003
Pubmed	The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease.	CLDN10 CHRNA5 CHRNB2 BMP7 SLC9A4 SLC9A3 TRPM5 SLC10A6	3.25e-07	212	107	8	19521566
Pubmed	International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.	CACNA1B CACNA1C CACNA1H	2.35e-06	9	107	3	16382099
Pubmed	Ion channel expression in the developing enteric nervous system.	CACNA1B CACNA1C KCND3 CACNA1H	5.17e-06	37	107	4	25798587
Pubmed	Nuclear factor-kappaB regulates estrogen receptor-alpha transcription in the human heart.	ESR1 NFKB1	9.38e-06	2	107	2	19584059
Pubmed	Indicaxanthin inhibits NADPH oxidase (NOX)-1 activation and NF-κB-dependent release of inflammatory mediators and prevents the increase of epithelial permeability in IL-1β-exposed Caco-2 cells.	NOX1 NFKB1	9.38e-06	2	107	2	23931157
Pubmed	ICI 182,780-regulated gene expression in DU145 prostate cancer cells is mediated by estrogen receptor-beta/NFkappaB crosstalk.	ESR1 NFKB1	9.38e-06	2	107	2	16756716
Pubmed	Targeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of DOCK1.	DOCK1 DOCK2	9.38e-06	2	107	2	28467910
Pubmed	CACNA1H downregulation induces skeletal muscle atrophy involving endoplasmic reticulum stress activation and autophagy flux blockade.	CACNA1C CACNA1H	9.38e-06	2	107	2	32332705
Pubmed	A cytoplasmic substrate of mitogen-activated protein kinase is responsible for estrogen receptor-alpha down-regulation in breast cancer cells: the role of nuclear factor-kappaB.	ESR1 NFKB1	9.38e-06	2	107	2	15056731
Pubmed	Assembly of human neuronal nicotinic receptor alpha5 subunits with alpha3, beta2, and beta4 subunits.	CHRNA5 CHRNB2	9.38e-06	2	107	2	8663494
Pubmed	Requirement of nicotinic acetylcholine receptor subunit beta2 in the maintenance of spiral ganglion neurons during aging.	CHRNA5 CHRNB2	9.38e-06	2	107	2	15788760
Pubmed	17beta-estradiol inhibits inflammatory gene expression by controlling NF-kappaB intracellular localization.	ESR1 NFKB1	9.38e-06	2	107	2	15798185
Pubmed	Origination and evolution of a human-specific transmembrane protein gene, c1orf37-dup.	TMEM183A TMEM183BP	9.38e-06	2	107	2	16644869
Pubmed	Plasticity of prefrontal attention circuitry: upregulated muscarinic excitability in response to decreased nicotinic signaling following deletion of α5 or β2 subunits.	CHRNA5 CHRNB2	9.38e-06	2	107	2	22072695
Pubmed	Chronic hypoxia selectively enhances L- and T-type voltage-dependent Ca2+ channel activity in pulmonary artery by upregulating Cav1.2 and Cav3.2.	CACNA1C CACNA1H	9.38e-06	2	107	2	23686856
Pubmed	Ca2+ influx through T- and L-type Ca2+ channels have different effects on myocyte contractility and induce unique cardiac phenotypes.	CACNA1C CACNA1H	9.38e-06	2	107	2	18832749
Pubmed	Distinct RGK GTPases differentially use α1- and auxiliary β-binding-dependent mechanisms to inhibit CaV1.2/CaV2.2 channels.	CACNA1B CACNA1C	9.38e-06	2	107	2	22590648
Pubmed	Catecholamine outflow from mouse and rat brain slice preparations evoked by nicotinic acetylcholine receptor activation and electrical field stimulation.	CHRNA5 CHRNB2	9.38e-06	2	107	2	17401441
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	MRPS27 WDR18 SMARCAD1 DHX33 OSGEP FANCD2 SLC25A12 SCFD1 LRBA TMCO1 KPNA1	1.15e-05	704	107	11	29955894
Pubmed	Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein.	CACNA1C KCND1 KCND3	1.25e-05	15	107	3	10479680
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	TMEM248 ERGIC2 SLC30A1 ADCY9 STT3A FANCD2 JAK1 XPO5 SLC4A10 UNC93B1 SCFD1 LRBA MYRF	2.36e-05	1061	107	13	33845483
Pubmed	Apocynin prevents cyclooxygenase 2 expression in human monocytes through NADPH oxidase and glutathione redox-dependent mechanisms.	NOX1 NFKB1	2.81e-05	3	107	2	15203187
Pubmed	The BEACH Protein LRBA Promotes the Localization of the Heterotrimeric G-protein Golf to Olfactory Cilia.	NBEA LRBA	2.81e-05	3	107	2	28814779
Pubmed	Role of DOCK2 and DOCK180 in fetal thymus colonization.	DOCK1 DOCK2	2.81e-05	3	107	2	19728314
Pubmed	USP39 Regulates NF-κB-Mediated Inflammatory Responses through Deubiquitinating K48-Linked IκBα.	NFKB1 USP39	2.81e-05	3	107	2	36651806
Pubmed	Association study between polymorphisms in the CACNA1A, CACNA1C, and CACNA1H genes and drug-resistant epilepsy in the Chinese Han population.	CACNA1C CACNA1H	2.81e-05	3	107	2	26216687
Pubmed	An additive interaction between the NFkappaB and estrogen receptor signalling pathways in human endometrial epithelial cells.	ESR1 NFKB1	2.81e-05	3	107	2	19955102
Pubmed	The role of the nAChR subunits α5, β2, and β4 on synaptic transmission in the mouse superior cervical ganglion.	CHRNA5 CHRNB2	2.81e-05	3	107	2	30891952
Pubmed	Interaction between P2X3 and oestrogen receptor (ER)α/ERβ in ATP-mediated calcium signalling in mice sensory neurones.	ESR1 P2RX3	2.81e-05	3	107	2	22175770
Pubmed	ZnT-1 enhances the activity and surface expression of T-type calcium channels through activation of Ras-ERK signaling.	SLC30A1 CACNA1H	2.81e-05	3	107	2	22572848
Pubmed	Unique clustering of A-type potassium channels on different cell types of the main olfactory bulb.	KCND1 KCND3	2.81e-05	3	107	2	18371079
Pubmed	Expression of voltage sensitive calcium channel (VSCC) L-type Cav1.2 (alpha1C) and T-type Cav3.2 (alpha1H) subunits during mouse bone development.	CACNA1C CACNA1H	2.81e-05	3	107	2	16059921
Pubmed	Iron chelation inhibits NF-kappaB-mediated adhesion molecule expression by inhibiting p22(phox) protein expression and NADPH oxidase activity.	NOX1 NFKB1	2.81e-05	3	107	2	16973969
Pubmed	T-type, but not L-type, voltage-gated calcium channels are dispensable for lymphatic pacemaking and spontaneous contractions.	CACNA1C CACNA1H	2.81e-05	3	107	2	31919478
Pubmed	Negative transcriptional regulation of human colonic smooth muscle Cav1.2 channels by p50 and p65 subunits of nuclear factor-kappaB.	CACNA1C NFKB1	2.81e-05	3	107	2	16285952
Pubmed	Estrogen regulation of the transient outward K(+) current involves estrogen receptor α in mouse heart.	ESR1 KCND3	2.81e-05	3	107	2	26205295
Pubmed	Hidden function of neuronal nicotinic acetylcholine receptor beta2 subunits in ganglionic transmission: comparison to alpha5 and beta4 subunits.	CHRNA5 CHRNB2	2.81e-05	3	107	2	15694199
Pubmed	Direct interaction between estrogen receptor alpha and NF-kappaB in the nucleus of living cells.	ESR1 NFKB1	2.81e-05	3	107	2	17590503
Pubmed	Molecular Basis of Regulating High Voltage-Activated Calcium Channels by S-Nitrosylation.	CACNA1B CACNA1C	2.81e-05	3	107	2	26507659
Pubmed	Association of single nucleotide polymorphisms in CACNA 1A/CACNA 1C/CACNA 1H calcium channel genes with diabetic peripheral neuropathy in Chinese population.	CACNA1C CACNA1H	2.81e-05	3	107	2	29581247
Pubmed	Toll-like receptor 9 agonist inhibits ERalpha-mediated transactivation by activating NF-kappaB in breast cancer cell lines.	ESR1 NFKB1	2.81e-05	3	107	2	19724876
Pubmed	NF-kappaB and estrogen receptor alpha interactions: Differential function in estrogen receptor-negative and -positive hormone-independent breast cancer cells.	ESR1 NFKB1	2.81e-05	3	107	2	19350539
Pubmed	Acetylcholine-stimulated [3H]GABA release from mouse brain synaptosomes is modulated by alpha4beta2 and alpha4alpha5beta2 nicotinic receptor subtypes.	CHRNA5 CHRNB2	2.81e-05	3	107	2	19139153
Pubmed	Indoxyl sulfate stimulates monocyte chemoattractant protein-1 expression in human umbilical vein endothelial cells by inducing oxidative stress through activation of the NADPH oxidase-nuclear factor-κB pathway.	NOX1 NFKB1	2.81e-05	3	107	2	20818133
Pubmed	Increased expression of the cardiac L-type calcium channel in estrogen receptor-deficient mice.	CACNA1C ESR1	2.81e-05	3	107	2	9236206
Pubmed	Regulation of TRPV5 transcription and expression by E2/ERα signalling contributes to inhibition of osteoclastogenesis.	ESR1 NFKB1	2.81e-05	3	107	2	30063124
Pubmed	Acetylcholine receptor (AChR) α5 subunit variant associated with risk for nicotine dependence and lung cancer reduces (α4β2)₂α5 AChR function.	CHRNA5 CHRNB2	2.81e-05	3	107	2	20881005
Pubmed	Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice.	UNC93B1 LRBA	2.81e-05	3	107	2	31097594
Pubmed	Nicotine enhances excitability of medial habenular neurons via facilitation of neurokinin signaling.	CHRNA5 CHRNB2	2.81e-05	3	107	2	24647947
Pubmed	Estrogen receptor α promotes Cav1.2 ubiquitination and degradation in neuronal cells and in APP/PS1 mice.	CACNA1C ESR1	2.81e-05	3	107	2	31012223
Pubmed	Karyopherin Subunit Alpha 1 Enhances the Malignant Behaviors of Colon Cancer Cells via Promoting Nuclear Factor-κB p65 Nuclear Translocation.	HECW2 KPNA1	2.81e-05	3	107	2	37038032
Pubmed	Electric field stimulation unmasks a subtle role for T-type calcium channels in regulating lymphatic contraction.	CACNA1C CACNA1H	2.81e-05	3	107	2	37739992
Pubmed	Probing the non-canonical interface for agonist interaction with an α5 containing nicotinic acetylcholine receptor.	CHRNA5 CHRNB2	2.81e-05	3	107	2	24144909
Pubmed	Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA).	KCND1 KCND3	2.81e-05	3	107	2	10729221
Pubmed	Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.	HTR6 CHRNA5 ADCY9 CHRNB2 HRH4	3.33e-05	118	107	5	19156168
Pubmed	Brugada Syndrome	CACNA1C KCND3 SCN3B	5.47e-05	24	107	3	20301690
Pubmed	Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia.	OR10P1 OR6C65 OR6C75	5.47e-05	24	107	3	24152035
Pubmed	Expression of P2X3 and TRPV1 receptors in primary sensory neurons from estrogen receptors-α and estrogen receptor-β knockout mice.	ESR1 P2RX3	5.60e-05	4	107	2	22581043
Pubmed	RNF20 Links Histone H2B Ubiquitylation with Inflammation and Inflammation-Associated Cancer.	H2BC1 NFKB1	5.60e-05	4	107	2	26854224
Pubmed	Subunit composition of α5-containing nicotinic receptors in the rodent habenula.	CHRNA5 CHRNB2	5.60e-05	4	107	2	22380605
Pubmed	A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs.	DOCK1 DOCK2	5.60e-05	4	107	2	15723800
Pubmed	NHE1, NHE2, and NHE3 contribute to regulation of intracellular pH in murine duodenal epithelial cells.	SLC9A4 SLC9A3	5.60e-05	4	107	2	10666043
Pubmed	CHRNB2 promoter region: association with subjective effects to nicotine and gene expression differences.	CHRNA5 CHRNB2	5.60e-05	4	107	2	20854418
Pubmed	Agonists for 13 trace amine-associated receptors provide insight into the molecular basis of odor selectivity.	TAAR3P TAAR8	5.60e-05	4	107	2	22545963
Pubmed	Unorthodox Acetylcholine Binding Sites Formed by α5 and β3 Accessory Subunits in α4β2* Nicotinic Acetylcholine Receptors.	CHRNA5 CHRNB2	5.60e-05	4	107	2	27645992
Pubmed	Selectivity of ABT-089 for alpha4beta2* and alpha6beta2* nicotinic acetylcholine receptors in brain.	CHRNA5 CHRNB2	5.60e-05	4	107	2	19481067
Pubmed	Differential role of nicotinic acetylcholine receptor subunits in physical and affective nicotine withdrawal signs.	CHRNA5 CHRNB2	5.60e-05	4	107	2	18184829
Pubmed	TNFα signaling exposes latent estrogen receptor binding sites to alter the breast cancer cell transcriptome.	ESR1 NFKB1	5.60e-05	4	107	2	25752574
Pubmed	Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP beta.	ESR1 NFKB1	5.60e-05	4	107	2	7651415
Pubmed	A protein phosphatase 2calpha-Ca2+ channel complex for dephosphorylation of neuronal Ca2+ channels phosphorylated by protein kinase C.	CACNA1B CACNA1C	5.60e-05	4	107	2	15728831
Pubmed	Jak1/Stat3 is an upstream signaling of NF-κB activation in Helicobacter pylori-induced IL-8 production in gastric epithelial AGS cells.	JAK1 NFKB1	5.60e-05	4	107	2	25837197
Pubmed	Association of genes coding for the alpha-4, alpha-5, beta-2 and beta-3 subunits of nicotinic receptors with cigarette smoking and nicotine dependence.	CHRNA5 CHRNB2	5.60e-05	4	107	2	19482438
Pubmed	Apoptotic body engulfment by hepatic stellate cells promotes their survival by the JAK/STAT and Akt/NF-kappaB-dependent pathways.	JAK1 NFKB1	5.60e-05	4	107	2	19457567
Pubmed	Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk.	CACNA1B CACNA1C	5.60e-05	4	107	2	19065143
Pubmed	Functional importance of L- and P/Q-type voltage-gated calcium channels in human renal vasculature.	CACNA1C CACNA1H	5.60e-05	4	107	2	21788606
Pubmed	Na(+)-dependent transporters mediate HCO(3)(-) salvage across the luminal membrane of the main pancreatic duct.	SLC9A4 SLC9A3	5.60e-05	4	107	2	10841524
Pubmed	Estrogen action and male fertility: roles of the sodium/hydrogen exchanger-3 and fluid reabsorption in reproductive tract function.	ESR1 SLC9A3	5.60e-05	4	107	2	11698654
Pubmed	Contributions of Na+/H+ exchanger isoforms to preimplantation development of the mouse.	SLC9A4 SLC9A3	5.60e-05	4	107	2	9590530
Pubmed	Endotoxin-induced vascular endothelial cell migration is dependent on TLR4/NF-κB pathway, NAD(P)H oxidase activation, and transient receptor potential melastatin 7 calcium channel activity.	NOX1 NFKB1	5.60e-05	4	107	2	25130439
Pubmed	Menin links estrogen receptor activation to histone H3K4 trimethylation.	ESR1 NFKB1	5.60e-05	4	107	2	16651450
Pubmed	Down-regulated in adenoma Cl/HCO3 exchanger couples with Na/H exchanger 3 for NaCl absorption in murine small intestine.	SLC9A4 SLC9A3	5.60e-05	4	107	2	18930060
Pubmed	G protein-gated inhibitory module of N-type (ca(v)2.2) ca2+ channels.	CACNA1B CACNA1C	5.60e-05	4	107	2	15953418
Pubmed	CBP mediates NF-κB-dependent histone acetylation and estrogen receptor recruitment to an estrogen response element in the BIRC3 promoter.	ESR1 NFKB1	5.60e-05	4	107	2	22083956
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	DOCK1 DOCK2 WDR18 SMARCAD1 FANCD2 XPO5 USP39 MAP2K7 KPNA1	8.11e-05	582	107	9	20467437
Pubmed	Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex.	DOCK1 DOCK2	9.32e-05	5	107	2	12134158
Pubmed	The Rac-specific exchange factors Dock1 and Dock5 are dispensable for the establishment of the glomerular filtration barrier in vivo.	DOCK1 DOCK2	9.32e-05	5	107	2	24365888
Pubmed	BCL8 is a novel, evolutionarily conserved human gene family encoding proteins with presumptive protein kinase A anchoring function.	NBEA LRBA	9.32e-05	5	107	2	12160729
Pubmed	Non-adherent cell-specific expression of DOCK2, a member of the human CDM-family proteins.	DOCK1 DOCK2	9.32e-05	5	107	2	10559471
Pubmed	Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels.	CACNA1B CACNA1C	9.32e-05	5	107	2	11296258
Pubmed	CBP Is a dosage-dependent regulator of nuclear factor-kappaB suppression by the estrogen receptor.	ESR1 NFKB1	9.32e-05	5	107	2	17932106
Pubmed	Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes.	CHRNA5 CHRNB2	9.32e-05	5	107	2	20377613
Pubmed	Identification of a cardiac isoform of the murine calcium channel alpha1C (Cav1.2-a) subunit and its preferential binding with the beta2 subunit.	CACNA1B CACNA1C	9.32e-05	5	107	2	16787652
Pubmed	Irinotecan pharmacogenetics: influence of pharmacodynamic genes.	CDC45 NFKB1	9.32e-05	5	107	2	18347181
Pubmed	Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice.	CACNA1B CACNA1C	9.32e-05	5	107	2	15451373
Cytoband	11p15.4	OR51A7 GVINP1 OR52E8 OR52E6 DENND5A OR51V1	7.95e-06	200	107	6	11p15.4
Cytoband	Ensembl 112 genes in cytogenetic band chr11q12	OR8H3 OR5AN1 OR5B17 MS4A2 P2RX3 MYRF OR5AP2	1.74e-05	345	107	7	chr11q12
Cytoband	12q13.2	OR10P1 OR6C65 OR6C75	2.96e-04	55	107	3	12q13.2
Cytoband	Ensembl 112 genes in cytogenetic band chr11p15	OR51A7 TRPM5 GVINP1 OR52E8 OR52E6 DENND5A OR51V1	3.68e-04	564	107	7	chr11p15
Cytoband	11q12.1	OR8H3 OR5AN1 OR5B17 OR5AP2	5.68e-04	161	107	4	11q12.1
Cytoband	1q44	OR14I1 OR14A16 OR2AJ1	2.22e-03	110	107	3	1q44
GeneFamily	Calcium voltage-gated channel subunits	CACNA1B CACNA1C CACNA1H	1.73e-04	26	76	3	253
GeneFamily	Olfactory receptors, family 14	OR14I1 OR14A16	3.61e-04	7	76	2	163
GeneFamily	Trace amine receptors	TAAR3P TAAR8	6.16e-04	9	76	2	188
GeneFamily	WD repeat domain containing\|BEACH domain containing	NBEA LRBA	6.16e-04	9	76	2	1230
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	MYO10 JAK1 NF2	1.21e-03	50	76	3	1293
GeneFamily	Solute carriers	SLC30A1 SLC9A4 SLC9A3 SLC25A12 SLC10A6 SLC4A10 SLC16A7	1.35e-03	395	76	7	752
GeneFamily	Cholinergic receptors nicotinic subunits	CHRNA5 CHRNB2	2.01e-03	16	76	2	173
GeneFamily	Zinc fingers MYND-type\|A-kinase anchoring proteins	NBEA NF2	6.58e-03	29	76	2	396
Drug	butamben	CACNA1B CACNA1C KCND1 KCND3 CACNA1H	6.03e-09	15	107	5	CID000002482
Drug	KN-62	CACNA1B CACNA1C CHKA ADCY9 JAK1 SLC9A3 P2RX3 KCND3 LRBA	1.42e-06	230	107	9	CID000003838
Disease	lung non-small cell carcinoma (is_implicated_in)	ESR1 CHRNA5 JAK1 XPO5 NFKB1 MAP2K7	7.23e-06	139	98	6	DOID:3908 (is_implicated_in)
Disease	Intellectual Disability	CACNA1B NBEA OSGEP STT3A PTCHD1 SCAMP5 SLC4A10 TMCO1 TRAPPC6A	1.85e-05	447	98	9	C3714756
Disease	Autistic Disorder	CACNA1C NBEA CHRNB2 PTCHD1 SLC25A12 SCAMP5 CACNA1H	2.73e-05	261	98	7	C0004352
Disease	Frontal Epilepsy, Benign, Childhood	CHRNB2 SLC4A10	6.52e-05	4	98	2	C0393671
Disease	Epilepsy, Cingulate	CHRNB2 SLC4A10	6.52e-05	4	98	2	C0393684
Disease	Epilepsy, Supplementary Motor	CHRNB2 SLC4A10	6.52e-05	4	98	2	C0393683
Disease	Epilepsy, Opercular	CHRNB2 SLC4A10	6.52e-05	4	98	2	C0393688
Disease	Anhydrotic Ectodermal Dysplasias	GJB6 BMS1	6.52e-05	4	98	2	C1706004
Disease	Epilepsy, Orbito-Frontal	CHRNB2 SLC4A10	6.52e-05	4	98	2	C0751643
Disease	Epilepsy, Anterior Fronto-Polar	CHRNB2 SLC4A10	6.52e-05	4	98	2	C0751642
Disease	Epilepsy, Frontal Lobe	CHRNB2 SLC4A10	6.52e-05	4	98	2	C0085541
Disease	Brugada Syndrome (disorder)	CACNA1C KCND3 SCN3B	6.83e-05	24	98	3	C1142166
Disease	Global developmental delay	CACNA1B NBEA STT3A SLC25A12 SCAMP5	8.37e-05	133	98	5	C0557874
Disease	nephrolithiasis (implicated_via_orthology)	SLC9A4 SLC9A3	1.08e-04	5	98	2	DOID:585 (implicated_via_orthology)
Disease	Hidrotic Ectodermal Dysplasia	GJB6 BMS1	1.08e-04	5	98	2	C0162361
Disease	Ectodermal Dysplasia	GJB6 BMS1	1.62e-04	6	98	2	C0013575
Disease	Aplasia Cutis Congenita	GJB6 BMS1	1.62e-04	6	98	2	C0282160
Disease	brain edema (is_marker_for)	CACNA1B SCN3B	2.27e-04	7	98	2	DOID:4724 (is_marker_for)
Disease	Brugada syndrome	CACNA1C SCN3B	3.02e-04	8	98	2	cv:C1142166
Disease	helix rolling	EDAR LRBA	3.02e-04	8	98	2	EFO_0007670
Disease	Anxiety States, Neurotic	CACNA1C CHRNA5 CHRNB2	4.26e-04	44	98	3	C0376280
Disease	Anxiety neurosis (finding)	CACNA1C CHRNA5 CHRNB2	4.26e-04	44	98	3	C1279420
Disease	Anxiety Disorders	CACNA1C CHRNA5 CHRNB2	4.26e-04	44	98	3	C0003469
Disease	Other specified cardiac arrhythmias	KCND3 SCN3B	5.89e-04	11	98	2	C0348626
Disease	Nodal rhythm disorder	KCND3 SCN3B	5.89e-04	11	98	2	C0264893
Disease	Ectopic rhythm	KCND3 SCN3B	5.89e-04	11	98	2	C1399226
Disease	CARDIAC CONDUCTION DEFECT, NONSPECIFIC (disorder)	KCND3 SCN3B	5.89e-04	11	98	2	C2748542
Disease	prostate cancer (is_implicated_in)	ESR1 JAK1 BMP7 NFKB1	6.36e-04	117	98	4	DOID:10283 (is_implicated_in)
Disease	outer ear morphology trait	EDAR LRBA	7.05e-04	12	98	2	EFO_0007664
Disease	Seizures	CACNA1B NBEA SLC30A1 CHRNA5 SCAMP5	8.18e-04	218	98	5	C0036572
Disease	Common variable immunodeficiency	NFKB1 LRBA	8.32e-04	13	98	2	cv:C0009447
Disease	Brugada Syndrome 1	KCND3 SCN3B	8.32e-04	13	98	2	C4551804
Disease	Sinus Node Dysfunction (disorder)	KCND3 SCN3B	1.11e-03	15	98	2	C0428908
Disease	Psychoses, Substance-Induced	HTR6 ESR1	1.44e-03	17	98	2	C0033941
Disease	breast cancer (is_implicated_in)	ESR1 FANCD2 XPO5 NFKB1	1.60e-03	150	98	4	DOID:1612 (is_implicated_in)
Disease	autism spectrum disorder (implicated_via_orthology)	NBEA CHRNB2 SCAMP5 LRBA	1.68e-03	152	98	4	DOID:0060041 (implicated_via_orthology)
Disease	transient cerebral ischemia (biomarker_via_orthology)	GJB6 CHKA JAK1 NFKB1	1.89e-03	157	98	4	DOID:224 (biomarker_via_orthology)
Disease	BRCAX breast cancer	DOCK1 ESR1	2.00e-03	20	98	2	EFO_0009443
Disease	Psychoses, Drug	HTR6 ESR1	2.20e-03	21	98	2	C0033937
Disease	Mood Disorders	CACNA1C HTR6 ESR1 NFKB1	2.42e-03	168	98	4	C0525045
Disease	Schizophrenia	CACNA1B CACNA1C HTR6 ESR1 CTXN3 CHRNA5 CHRNB2 MAP2K7 KPNA1	2.71e-03	883	98	9	C0036341
Disease	blood phosphate measurement	ESR1 ADCY9 SERPINF2 KPNA1	2.74e-03	174	98	4	EFO_0010972
Disease	Cardiac Arrhythmia	CACNA1C KCND3	3.12e-03	25	98	2	C0003811
Disease	response to gemcitabine	DOCK1 CACNA1C	3.12e-03	25	98	2	GO_0036272
Disease	hepatocellular carcinoma (is_implicated_in)	JAK1 NF2 XPO5 NFKB1	3.16e-03	181	98	4	DOID:684 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
SFSTEIVVMMLFLTI	MS4A2	176	Q01362
VSLFTSDLMVGLVVM	HTR6	66	P50406
FFLAISMVGTDFSMI	BDP1	311	A6H8Y1
SSMSLEQKMTFVFVI	CTXN3	21	Q4LDR2
ELDFSTFLTIMHMQI	CALML4	106	Q96GE6
FLDSFSIMSMSIFLL	ABCA4	701	P78363
MMAFTADLFSLVAQT	SERPINF2	86	P08697
LTFNTVAFTEVMGML	EPN3	46	Q9H201
VSLIAFTTMALLTIM	ERGIC2	36	Q96RQ1
MTLTVFEKEFINMTT	GVINP1	1961	Q7Z2Y8
MASTASEIIAFMVSI	CLDN10	1	P78369
FLTDADMVMSFVNLV	BMP7	126	P18075
FEDKLLMSDIVFMRT	BMS1	1086	Q14692
TGVFTFEMVIKMIDL	CACNA1B	1191	Q00975
LNIVFTSMFSMECVL	CACNA1B	1506	Q00975
TSMFSMECVLKIIAF	CACNA1B	1511	Q00975
FITLMTMFAIISSLI	DISP1	526	Q96F81
ISLAFFEAASMMRQV	JAK1	631	P23458
MAFLLAVFTLMVTLA	OR6C65	196	A6NJZ3
VMLLSLFEEEIMSYV	HECW2	1136	Q9P2P5
MTIALILMVTSATEF	NOX1	181	Q9Y5S8
FSLTMAIIIFATVMF	KCND1	331	Q9NSA2
FSLTMAIIIFATVMF	KCND3	326	Q9UK17
VAEEVSLFSMTDMIL	POR	16	P16435
SLFSMTDMILFSLIV	POR	21	P16435
VMKEFSMTDIDLTTL	GABPA	201	Q06546
TFLIFLLVMMSAITV	ASAH2	11	Q9NR71
TALIIAMSTIFIMAI	EDAR	186	Q9UNE0
MVEIFDMLLATSSRF	ESR1	421	P03372
FITNTDVFIAMELMG	MAP2K7	186	O14733
GFTVMESSVLLIMSL	OR51A7	106	Q8NH64
LSFMESSVLLTMAFD	OR51V1	116	Q9H2C8
IHFFTVMESIVLVAM	OR52E6	106	Q96RD3
AMSTCITHIIVIFFM	OR4N2	236	Q8NGD1
FREVITAMDVMQFSK	MYO10	306	Q9HD67
SAAFLLSVMAFVDMF	SLC16A7	281	O60669
TALEIFMANRVAVMF	LRBA	2151	P50851
DEVFTVLYAMVTTML	OR13J1	271	Q8NGT2
MAFSSFIVISCVMIV	OR5AP2	206	Q8NGF4
TVFAMLVEITERAMA	OSGEP	236	Q9NPF4
TDTFFVQVMTAILTM	OR5AN1	191	Q8NGI8
EMLIFIIAGSTLMVS	OR8H3	196	Q8N146
LISMAVSFVESMFVT	PKD1L2	1856	Q7Z442
TFTVRIVTMDAEMEF	NF2	21	P35240
VDDLMSVLSVTIFMF	GPR149	76	Q86SP6
EASMAVISLLFLAVM	ITPRIPL1	6	Q6GPH6
MSIMNSFVTDIFERI	H2BC1	61	Q96A08
MIFVTLSIMVTVFAI	CHRNA5	321	P30532
FLASDVVFATMSLME	CDC45	371	O75419
VLAAMMALFTVSTFE	CACNA1C	1121	Q13936
KMRTDVVDFLMETFI	DOCK1	956	Q14185
TSSELVDFLMETFIM	DOCK2	961	Q92608
TVVAVVMDIFTDMEL	FAM83C	171	Q9BQN1
AMVLESVMFAILAER	CHKA	176	P35790
FLSFTRDDQSVMVEM	FRRS1	221	Q6ZNA5
MLMFTTTVLTCIAFV	FRRS1	416	Q6ZNA5
FTIFMISASVICMLL	GJB6	191	O95452
MDLSVETLFSFMQER	BORCS5	121	Q969J3
KVIVMSATMDVDLFS	DHX33	226	Q9H6R0
KEELQMLFFSETLAM	CATIP	41	Q7Z7H3
MLFFSETLAMVSDTG	CATIP	46	Q7Z7H3
AVSIRMVFFLEDVMA	ADCY9	836	O60503
LMTVAETITALMFPF	DENND5A	321	Q6IQ26
LVMNTVMSFRFVLEG	DNAH14	1211	Q0VDD8
AAFAIMVIFTLSVSM	TMEM259	306	Q4ZIN3
VGSFISLTAVMLMIF	MT-CO1	456	P00395
EISNIVFTSMFALEM	CACNA1H	826	O95180
VMFTVMAVFSFIALS	SCAMP5	156	Q8TAC9
FVVFFRVMMAELEKT	FANCD2	1231	Q9BXW9
ETPIMMEAENFTIFI	P2RX3	161	P56373
MAFFLAVVTLMVTLT	OR6C75	196	A6NL08
LFVIFIMSVTENTLM	OR2AJ1	31	Q8NGZ0
MDTDKIASVFYTMII	OR5B17	266	Q8NGF7
SEISVMTATIVFIMI	OR10P1	196	Q8NGE3
MANLTIVTEFILMGF	OR14A16	1	Q8NHC5
MDNLTKVTEFLLMEF	OR14I1	1	A6ND48
HFFTAMESIVLVAMA	OR52E8	111	Q6IFG1
VTLAFFMSLVAFAIM	HRH4	16	Q9H3N8
LSVVFEVMMQEAFEV	MRPS27	161	Q92552
LSMATTDFLLGFVIM	TAAR3P	71	Q9P1P4
VVFMISVSAMAIAFL	TMEM248	21	Q9NWD8
EMSTMFADTLLIVFI	TMCO1	51	Q9UM00
DRVVLFSQFTMMLDI	SMARCAD1	871	Q9H4L7
FSQFTMMLDILEVLL	SMARCAD1	876	Q9H4L7
ETMVESTFMYLTLDL	USP39	381	Q53GS9
ADFLVGVTVMLFSMV	TAAR8	76	Q969N4
GVTVMLFSMVRTVES	TAAR8	81	Q969N4
DVVASRMFLVAKTME	PTCHD1	641	Q96NR3
MIFTLFTINVSTDMR	TMEM183BP	311	Q1AE95
GVITSDMIEMIFSKS	KPNA1	81	P52294
EDLIMSFTVSMAIGL	MYCT1	66	Q8N699
AVTFLSRLMAMVDVL	NBEA	1431	Q8NFP9
SRLMAMVDVLVFASS	NBEA	1436	Q8NFP9
MLASSAETIIFMFLG	SLC9A3	341	P48764
KMLSSVSETLIFIFM	SLC9A4	356	Q6AI14
VASGMILVMAFFLIT	STT3A	456	P46977
SVLFDVSIMAVTMDL	WDR18	211	Q9BV38
TAVMMEEFVQLFREA	URB1	486	O60287
LMFTMVLVTFSIVTS	CHRNB2	301	P17787
MISGLDFSDIMVTIR	SLC25A12	176	O75746
IVVESVLMAVAFLAM	UNC93B1	286	Q9H1C4
MIFTLFTINVSTDMR	TMEM183A	311	Q8IXX5
TVLAMDFMVFTLRLI	TRPM5	836	Q9NZQ8
IFILMGSSVFMTSIL	SLC4A10	916	Q6U841
MTLFLESVITQMFRT	XPO5	506	Q9HAV4
EDFTSVVSEIMMYIL	SCN3B	151	Q9NY72
METVMDTIVDSLFCF	SCFD1	186	Q8WVM8
ELVFTVVSTVMMGLL	SLC10A6	31	Q3KNW5
MADTVLFEFLHTEMV	TRAPPC6A	1	O75865
FLTMHASIFTLTVMS	UTS2R	131	Q9UKP6
MALRSVMFSDVSIDF	ZFP82	1	Q8N141
ALTFMFMVLEVVVSR	SLC30A1	16	Q9Y6M5
NSMEFITLSRLMETF	VPS54	631	Q9P1Q0
FHMFILSMVTVDVIV	NALCN	386	Q8IZF0
ALVVVMAFSVVSMST	MYRF	771	Q9Y2G1
EMDLSVVRLMFTAFL	NFKB1	206	P19838