Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsodium channel inhibitor activity

NEDD4L NEDD4

1.03e-048392GO:0019871
GeneOntologyBiologicalProcesspositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

RICTOR MERTK CALCR F2R UBE3A NEDD4

3.09e-06217396GO:0051897
GeneOntologyBiologicalProcessregulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

RICTOR MERTK CALCR F2R UBE3A NEDD4

3.58e-05334396GO:0051896
GeneOntologyBiologicalProcessestablishment of meiotic spindle localization

MYH9 SPIRE2

5.20e-056392GO:0051295
GeneOntologyBiologicalProcessmuscle system process

GATA6 MYH11 SORBS2 GATA5 NEDD4L F2R SCN7A

6.54e-05547397GO:0003012
GeneOntologyBiologicalProcessphosphatidylinositol 3-kinase/protein kinase B signal transduction

RICTOR MERTK CALCR F2R UBE3A NEDD4

7.55e-05382396GO:0043491
GeneOntologyBiologicalProcessregulation of plasma membrane repair

MYH9 AHNAK

9.68e-058392GO:1905684
GeneOntologyBiologicalProcessregulation protein catabolic process at postsynapse

NEDD4L NEDD4

1.55e-0410392GO:0140252
GeneOntologyBiologicalProcessprogesterone receptor signaling pathway

UBE3A NEDD4

2.27e-0412392GO:0050847
DomainGATA_N

GATA6 GATA5

1.21e-053382IPR008013
DomainGATA-N

GATA6 GATA5

1.21e-053382PF05349
DomainHECT

NEDD4L UBE3A NEDD4

2.20e-0527383PF00632
DomainHECTc

NEDD4L UBE3A NEDD4

2.20e-0527383SM00119
DomainHECT_dom

NEDD4L UBE3A NEDD4

2.20e-0527383IPR000569
DomainHECT

NEDD4L UBE3A NEDD4

2.20e-0527383PS50237
DomainZnF_GATA

GATA6 GATA5

2.63e-0412382SM00401
DomainMyosin_N

MYH9 MYH11

4.16e-0415382IPR004009
DomainZnf_GATA

GATA6 GATA5

4.16e-0415382IPR000679
DomainMyosin_N

MYH9 MYH11

4.16e-0415382PF02736
DomainGATA

GATA6 GATA5

4.16e-0415382PF00320
DomainGATA_ZN_FINGER_1

GATA6 GATA5

4.75e-0416382PS00344
DomainGATA_ZN_FINGER_2

GATA6 GATA5

4.75e-0416382PS50114
DomainIQ

MYH9 MYH11 SCN7A

5.94e-0481383SM00015
DomainMyosin_tail_1

MYH9 MYH11

6.04e-0418382PF01576
DomainMyosin_tail

MYH9 MYH11

6.04e-0418382IPR002928
DomainMyosin-like_IQ_dom

MYH9 MYH11

6.74e-0419382IPR027401
Domain-

MYH9 MYH11

6.74e-04193824.10.270.10
DomainIQ_motif_EF-hand-BS

MYH9 MYH11 SCN7A

8.08e-0490383IPR000048
DomainMYOSIN_MOTOR

MYH9 MYH11

2.71e-0338382PS51456
DomainMyosin_head

MYH9 MYH11

2.71e-0338382PF00063
DomainMyosin_head_motor_dom

MYH9 MYH11

2.71e-0338382IPR001609
DomainMYSc

MYH9 MYH11

2.71e-0338382SM00242
Domain-

NEDD4L SNRNP200 NEDD4

3.36e-031483832.60.40.150
DomainWW

NEDD4L NEDD4

4.11e-0347382PF00397
DomainWW

NEDD4L NEDD4

4.29e-0348382SM00456
DomainC2_dom

NEDD4L SNRNP200 NEDD4

4.48e-03164383IPR000008
DomainWW_DOMAIN_2

NEDD4L NEDD4

4.83e-0351382PS50020
DomainWW_DOMAIN_1

NEDD4L NEDD4

4.83e-0351382PS01159
DomainWW_dom

NEDD4L NEDD4

5.01e-0352382IPR001202
DomainHMG_box

SOX8 LEF1

5.20e-0353382PF00505
DomainHMG_BOX_2

SOX8 LEF1

5.40e-0354382PS50118
DomainHMG

SOX8 LEF1

5.40e-0354382SM00398
Domain-

SOX8 LEF1

5.59e-03553821.10.30.10
Domain-

GATA6 GATA5

6.00e-03573823.30.50.10
Pubmed

Faciogenital Dysplasia 5 supports cancer stem cell traits in basal-like breast cancer by enhancing EGFR stability.

MYH9 MYH11 NEDD4L XRCC6 AHNAK NEDD4

7.12e-0819139633762435
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

RICTOR MYH9 MYH11 SNRNP200 XRCC6 AHNAK

9.91e-0820239633005030
Pubmed

Distinct characteristics of two human Nedd4 proteins with respect to epithelial Na(+) channel regulation.

NEDD4L NEDD4

1.23e-06239211502596
Pubmed

Nedd4 and Nedd4-2: ubiquitin ligases at work in the neuron.

NEDD4L NEDD4

1.23e-06239223262292
Pubmed

Down-regulating destruction: phosphorylation regulates the E3 ubiquitin ligase Nedd4-2.

NEDD4L NEDD4

1.23e-06239219602703
Pubmed

A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel.

NEDD4L NEDD4

1.23e-06239211149908
Pubmed

Dietary sodium modulates nephropathy in Nedd4-2-deficient mice.

NEDD4L NEDD4

1.23e-06239231802037
Pubmed

Physiological Functions of the Ubiquitin Ligases Nedd4-1 and Nedd4-2.

NEDD4L NEDD4

1.23e-06239237962894
Pubmed

PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.

CCNH MYH9 MYH11 SNRNP200 XRCC6 AHNAK

2.08e-0634039624332808
Pubmed

Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes.

MYH9 UBE3A SNRNP200 XRCC6

2.56e-068539416051665
Pubmed

A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes.

UBA6 NEDD4L UBE3A NEDD4

2.94e-068839427182664
Pubmed

Regulation of Nedd4-2 self-ubiquitination and stability by a PY motif located within its HECT-domain.

NEDD4L NEDD4

3.67e-06339218498246
Pubmed

Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone-SGK1-Nedd4-2 pathway.

NEDD4L NEDD4

3.67e-06339221852580
Pubmed

The high-affinity choline transporter CHT1 is regulated by the ubiquitin ligase Nedd4-2.

NEDD4L NEDD4

3.67e-06339222361880
Pubmed

Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitination.

NEDD4L NEDD4

3.67e-06339215217910
Pubmed

Nedd4-2-mediated ubiquitination facilitates processing of surfactant protein-C.

NEDD4L NEDD4

3.67e-06339219423771
Pubmed

Perception of differentiation cues by GATA factors in primitive endoderm lineage determination of mouse embryonic stem cells.

GATA6 GATA5

3.67e-06339216162334
Pubmed

Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein.

NEDD4L NEDD4

3.67e-06339212050153
Pubmed

Interaction of serum- and glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation.

NEDD4L NEDD4

3.67e-06339220730100
Pubmed

Nedd4-2 but not Nedd4-1 is critical for protein kinase C-regulated ubiquitination, expression, and transport activity of human organic anion transporter 1.

NEDD4L NEDD4

3.67e-06339226823285
Pubmed

Mutations in TNK2 in severe autosomal recessive infantile onset epilepsy.

NEDD4L NEDD4

3.67e-06339223686771
Pubmed

Alternative splicing determines the domain structure of WWP1, a Nedd4 family protein.

NEDD4L NEDD4

3.67e-06339211779188
Pubmed

Characterization of the interactions between Nedd4-2, ENaC, and sgk-1 using surface plasmon resonance.

NEDD4L NEDD4

3.67e-06339212729930
Pubmed

Self-regulated alternative splicing at the AHNAK locus.

AHNAK PRX

3.67e-06339221940993
Pubmed

Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation.

GATA6 GATA5

3.67e-0633929566909
Pubmed

14-3-3 proteins modulate the expression of epithelial Na+ channels by phosphorylation-dependent interaction with Nedd4-2 ubiquitin ligase.

NEDD4L NEDD4

3.67e-06339215677482
Pubmed

GATA-5: a transcriptional activator expressed in a novel temporally and spatially-restricted pattern during embryonic development.

GATA6 GATA5

3.67e-0633929119112
Pubmed

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.

UBA6 NEDD4L UBE3A NEDD4

3.99e-069539429643511
Pubmed

Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.

RICTOR MYH9 SNRNP200 XRCC6 AHNAK

4.18e-0621539535973513
Pubmed

USP45 and Spindly are part of the same complex implicated in cell migration.

MYH9 MYH11 SNRNP200 XRCC6 AHNAK

6.44e-0623539530258100
Pubmed

SGK1/Nedd4-2 signaling pathway regulates the activity of human organic anion transporters 3.

NEDD4L NEDD4

7.34e-06439228608480
Pubmed

The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1.

NEDD4L NEDD4

7.34e-06439220026598
Pubmed

C2-lacking isoform of Nedd4-2 regulates excitatory synaptic strength through GluA1 ubiquitination-independent mechanisms.

NEDD4L NEDD4

7.34e-06439231357244
Pubmed

Kir5.1 regulates Nedd4-2-mediated ubiquitination of Kir4.1 in distal nephron.

NEDD4L NEDD4

7.34e-06439229897283
Pubmed

Loss of smooth muscle myosin heavy chain results in the bladder and stomach developing lesion during foetal development in mice.

MYH9 MYH11

7.34e-06439229932067
Pubmed

β-catenin coordinates with Jup and the TCF1/GATA6 axis to regulate human embryonic stem cell fate.

GATA6 LEF1

7.34e-06439228943339
Pubmed

The Ubiquitin Ligase Itch and Ubiquitination Regulate BFRF1-Mediated Nuclear Envelope Modification for Epstein-Barr Virus Maturation.

NEDD4L NEDD4

7.34e-06439227466427
Pubmed

Lung Krüppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase.

GATA6 GATA5

7.34e-06439211375995
Pubmed

Efferocytosis induces macrophage proliferation to help resolve tissue injury.

RICTOR MERTK

7.34e-06439234784501
Pubmed

Wnt2 is a direct downstream target of GATA6 during early cardiogenesis.

GATA6 GATA5

7.34e-06439216621466
Pubmed

GRK2 interacts with and phosphorylates Nedd4 and Nedd4-2.

NEDD4L NEDD4

7.34e-06439217544362
Pubmed

BMP-mediated induction of GATA4/5/6 blocks somitic responsiveness to SHH.

GATA6 GATA5

7.34e-06439225294942
Pubmed

GATA- and Smad1-dependent enhancers in the Smad7 gene differentially interpret bone morphogenetic protein concentrations.

GATA6 GATA5

7.34e-06439212944489
Pubmed

NEDD4-2 associates with gamma(c) and regulates its degradation rate.

NEDD4L NEDD4

7.34e-06439219615332
Pubmed

Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels.

NEDD4L NEDD4

7.34e-06439222024150
Pubmed

Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel.

NEDD4L NEDD4

7.34e-06439211696533
Pubmed

Nedd4-2-dependent ubiquitylation and regulation of the cardiac potassium channel hERG1.

NEDD4L NEDD4

7.34e-06439221463633
Pubmed

Chemically synthesized cinobufagin suppresses nasopharyngeal carcinoma metastasis by inducing ENKUR to stabilize p53 expression.

MYH9 UBE3A

1.22e-05539235114328
Pubmed

Oligomerization of the HECT ubiquitin ligase NEDD4-2/NEDD4L is essential for polyubiquitin chain assembly.

NEDD4L NEDD4

1.22e-05539230287686
Pubmed

An obligatory heterodimer of 14-3-3beta and 14-3-3epsilon is required for aldosterone regulation of the epithelial sodium channel.

NEDD4L NEDD4

1.22e-05539218687683
Pubmed

Ubiquitin-specific protease 2-45 (Usp2-45) binds to epithelial Na+ channel (ENaC)-ubiquitylating enzyme Nedd4-2.

NEDD4L NEDD4

1.22e-05539221478478
Pubmed

The ESCRT pathway and HIV-1 budding.

NEDD4L NEDD4

1.22e-05539219143627
Pubmed

Rescue of DeltaF508-CFTR by the SGK1/Nedd4-2 signaling pathway.

NEDD4L NEDD4

1.22e-05539219617352
Pubmed

Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response.

NEDD4L NEDD4

1.22e-05539225631046
Pubmed

The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family.

NEDD4L NEDD4

1.22e-05539217289006
Pubmed

Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins.

NEDD4L NEDD4

1.22e-05539215548568
Pubmed

Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth.

NEDD4L NEDD4

1.22e-05539225157163
Pubmed

Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases.

UBE3A NEDD4

1.22e-0553929182527
Pubmed

Targeting of PYK2 Synergizes with EGFR Antagonists in Basal-like TNBC and Circumvents HER3-Associated Resistance via the NEDD4-NDRG1 Axis.

NEDD4L NEDD4

1.22e-05539227793840
Pubmed

The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation.

NEDD4L NEDD4

1.22e-05539222385262
Pubmed

NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor.

NEDD4L NEDD4

1.22e-05539231867777
Pubmed

A Nedd4 E3 Ubiquitin Ligase Pathway Inhibits Robo1 Repulsion and Promotes Commissural Axon Guidance across the Midline.

NEDD4L NEDD4

1.22e-05539236002265
Pubmed

Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons.

NEDD4L NEDD4

1.22e-05539219706893
Pubmed

The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels.

NEDD4L NEDD4

1.22e-05539218577513
Pubmed

Telokin expression is restricted to smooth muscle tissues during mouse development.

MYH9 MYH11

1.22e-05539211121372
Pubmed

N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking.

NEDD4L NEDD4

1.83e-05639215252135
Pubmed

Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes.

UBE3A NEDD4

1.83e-0563929990509
Pubmed

The zinc finger-containing transcription factor Gata-4 is expressed in the developing endocrine pancreas and activates glucagon gene expression.

GATA6 GATA5

1.83e-05639215539431
Pubmed

Ubiquitin-specific Protease 36 (USP36) Controls Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-2 (Nedd4-2) Actions over the Neurotrophin Receptor TrkA and Potassium Voltage-gated Channels 7.2/3 (Kv7.2/3).

NEDD4L NEDD4

1.83e-05639227445338
Pubmed

Cell survival through Trk neurotrophin receptors is differentially regulated by ubiquitination.

NEDD4L NEDD4

1.83e-05639216701206
Pubmed

p34 is a novel regulator of the oncogenic behavior of NEDD4-1 and PTEN.

CCNH NEDD4

1.83e-05639224141722
Pubmed

Regulation of Itch and Nedd4 E3 Ligase Activity and Degradation by LRAD3.

NEDD4L NEDD4

1.83e-05639226854353
Pubmed

β-Sheet Augmentation Is a Conserved Mechanism of Priming HECT E3 Ligases for Ubiquitin Ligation.

NEDD4L NEDD4

1.83e-05639229964046
Pubmed

Lysosomal-associated protein transmembrane 5 ameliorates non-alcoholic steatohepatitis by promoting the degradation of CDC42 in mice.

NEDD4L NEDD4

1.83e-05639237156795
Pubmed

Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5.

NEDD4L UBE3A

1.83e-0563928576257
Pubmed

N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein.

NEDD4L NEDD4

1.83e-05639211748237
Pubmed

Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways.

MYH9 SNRNP200 XRCC6 AHNAK

2.56e-0515239416009940
Pubmed

A cell-based high-throughput screening method based on a ubiquitin-reference technique for identifying modulators of E3 ligases.

NEDD4L NEDD4

2.56e-05739230587574
Pubmed

Gata4 expression in lateral mesoderm is downstream of BMP4 and is activated directly by Forkhead and GATA transcription factors through a distal enhancer element.

GATA6 GATA5

2.56e-05739215987774
Pubmed

Lysine 63-linked polyubiquitination of the dopamine transporter requires WW3 and WW4 domains of Nedd4-2 and UBE2D ubiquitin-conjugating enzymes.

NEDD4L NEDD4

2.56e-05739220051513
Pubmed

HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK.

NEDD4L NEDD4

2.56e-05739220086093
Pubmed

Lys-63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized α-synuclein.

NEDD4L NEDD4

2.56e-05739224831002
Pubmed

Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases.

NEDD4L NEDD4

2.56e-05739211046148
Pubmed

Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming.

NEDD4L NEDD4

2.56e-05739223644597
Pubmed

NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition.

RICTOR LEF1

2.56e-05739226588989
Pubmed

GATA factors and androgen receptor collaborate to transcriptionally activate the Rhox5 homeobox gene in Sertoli cells.

GATA6 GATA5

2.56e-05739218212046
Pubmed

The ubiquitin-protein ligases Nedd4 and Nedd4-2 show similar ubiquitin-conjugating enzyme specificities.

NEDD4L NEDD4

2.56e-05739216337426
Pubmed

LOXL2 Upregulates Phosphorylation of Ezrin to Promote Cytoskeletal Reorganization and Tumor Cell Invasion.

MYH9 MYH11 SNRNP200 XRCC6 AHNAK

3.16e-0532739531409639
Pubmed

The necdin interactome: evaluating the effects of amino acid substitutions and cell stress using proximity-dependent biotinylation (BioID) and mass spectrometry.

MYH9 POTEJ SNRNP200 XRCC6 AHNAK

3.30e-0533039532529326
Pubmed

The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel.

NEDD4L NEDD4

3.42e-05839211244092
Pubmed

Ndfip1 expression in developing neurons indicates a role for protein ubiquitination by Nedd4 E3 ligases during cortical development.

NEDD4L NEDD4

3.42e-05839224036464
Pubmed

Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain.

NEDD4L NEDD4

3.42e-05839217719543
Pubmed

Gata6 restricts Isl1 to the posterior of nascent hindlimb buds through Isl1 cis-regulatory modules.

GATA6 GATA5

3.42e-05839229197504
Pubmed

Distinct Roles of Smooth Muscle and Non-muscle Myosin Light Chain-Mediated Smooth Muscle Contraction.

MYH9 MYH11

3.42e-05839233424621
Pubmed

The cardiac determination factor, Nkx2-5, is activated by mutual cofactors GATA-4 and Smad1/4 via a novel upstream enhancer.

GATA6 GATA5

3.42e-05839214662776
Pubmed

ZFAND5/ZNF216 is an activator of the 26S proteasome that stimulates overall protein degradation.

UBE3A NEDD4

4.39e-05939230254168
Pubmed

Regulation of BMP-dependent chondrogenesis in early limb mesenchyme by TGFbeta signals.

GATA6 GATA5

4.39e-05939220501701
Pubmed

Functional regulation of the epithelial Na+ channel by IkappaB kinase-beta occurs via phosphorylation of the ubiquitin ligase Nedd4-2.

NEDD4L NEDD4

4.39e-05939218981174
Pubmed

Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages.

UBE3A NEDD4

4.39e-05939217426036
Pubmed

S5a/Rpn10, a UIM-protein, as a universal substrate for ubiquitination.

UBE3A NEDD4

4.39e-05939222350919
InteractionLRRC31 interactions

RICTOR MYH9 MYH11 SNRNP200 XRCC6 AHNAK

2.17e-06205386int:LRRC31
InteractionSCN2A interactions

MYH9 NEDD4L NEDD4

5.87e-0619383int:SCN2A
InteractionLGR4 interactions

MYH9 MYH11 POTEJ NEDD4L SNRNP200 NEDD4

8.88e-06262386int:LGR4
InteractionANXA2 interactions

RICTOR MYH9 PUS3 NEDD4L UBE3A AHNAK NEDD4

1.16e-05419387int:ANXA2
InteractionPPP5D1P interactions

MYH9 MYH11

2.07e-054382int:PPP5D1P
InteractionPRRG3 interactions

NEDD4L NEDD4

3.45e-055382int:PRRG3
InteractionSMAD4 interactions

GATA6 UBA6 RICTOR GATA5 LEF1 UBE3A XRCC6

5.20e-05530387int:SMAD4
InteractionARRDC3 interactions

PHF1 NEDD4L F2R SNRNP200 NEDD4

6.04e-05224385int:ARRDC3
InteractionUBE2L6 interactions

UBA6 NEDD4L UBE3A NEDD4

6.61e-05116384int:UBE2L6
InteractionMYH9 interactions

RICTOR MYH9 MYH11 SORBS2 DNAH5 UBE3A XRCC6 AHNAK

6.68e-05754388int:MYH9
InteractionAURKC interactions

MYH11 NEDD4L NEDD4

7.25e-0543383int:AURKC
InteractionRUVBL1 interactions

RICTOR MYH9 LEF1 SNRNP200 XRCC6 AHNAK NEDD4

8.68e-05575387int:RUVBL1
InteractionPSMB6 interactions

UBA6 RICTOR MYH9 UBE3A L3MBTL4

8.87e-05243385int:PSMB6
InteractionSMAD7 interactions

NEDD4L LEF1 XRCC6 NEDD4

9.40e-05127384int:SMAD7
InteractionCYYR1 interactions

NEDD4L NEDD4

9.62e-058382int:CYYR1
InteractionPMEPA1 interactions

MYH9 NEDD4L NEDD4

1.21e-0451383int:PMEPA1
InteractionMS4A10 interactions

NEDD4L NEDD4

1.54e-0410382int:MS4A10
InteractionPRRG2 interactions

NEDD4L NEDD4

1.54e-0410382int:PRRG2
InteractionKCNA3 interactions

UBA6 RICTOR MYH9 NEDD4L DNAH5 SNRNP200 XRCC6 AHNAK

1.82e-04871388int:KCNA3
InteractionSCN10A interactions

NEDD4L NEDD4

1.88e-0411382int:SCN10A
InteractionTMEM252 interactions

NEDD4L NEDD4

1.88e-0411382int:TMEM252
InteractionILDR1 interactions

NEDD4L NEDD4

1.88e-0411382int:ILDR1
InteractionSPINK1 interactions

SERPINI2 UBE3A

2.26e-0412382int:SPINK1
InteractionENO1 interactions

RICTOR MYH9 MYH11 UBE3A XRCC6 AHNAK NEDD4

2.94e-04701387int:ENO1
InteractionSPDL1 interactions

MYH9 MYH11 SNRNP200 XRCC6 AHNAK

2.97e-04315385int:SPDL1
InteractionAHNAK interactions

RICTOR MYH9 UBE3A AHNAK PRX

3.10e-04318385int:AHNAK
InteractionMOB3A interactions

NEDD4L NEDD4

3.11e-0414382int:MOB3A
InteractionUBFD1 interactions

RICTOR MYH9 UBE3A

3.37e-0472383int:UBFD1
InteractionKLF2 interactions

GATA6 GATA5

3.58e-0415382int:KLF2
InteractionPRRG1 interactions

NEDD4L NEDD4

3.58e-0415382int:PRRG1
InteractionTRIR interactions

RICTOR SNRNP200 XRCC6

3.66e-0474383int:TRIR
InteractionCHMP4B interactions

RICTOR MYH9 MYH11 SORBS2 SNRNP200 XRCC6 AHNAK

3.67e-04727387int:CHMP4B
InteractionBGLT3 interactions

MYH9 SNRNP200 XRCC6

3.80e-0475383int:BGLT3
InteractionTARDBP interactions

RICTOR MYH9 UBE3A SNRNP200 XRCC6 AHNAK

3.92e-04520386int:TARDBP
InteractionDAZAP2 interactions

NEDD4L LEF1 UBE3A NEDD4

4.06e-04186384int:DAZAP2
InteractionPRR16 interactions

NEDD4L NEDD4

4.09e-0416382int:PRR16
InteractionSCN3A interactions

NEDD4L NEDD4

4.09e-0416382int:SCN3A
InteractionSUSD6 interactions

NEDD4L NEDD4

4.09e-0416382int:SUSD6
InteractionROBO3 interactions

CXCL14 NEDD4L

4.09e-0416382int:ROBO3
InteractionDSTN interactions

MYH9 MYH11 UBE3A SCN7A

4.14e-04187384int:DSTN
InteractionSGK1 interactions

RICTOR NEDD4L NEDD4

4.60e-0480383int:SGK1
InteractionTMEM92 interactions

NEDD4L NEDD4

4.62e-0417382int:TMEM92
InteractionTMEM255A interactions

NEDD4L NEDD4

4.62e-0417382int:TMEM255A
InteractionFBP1 interactions

MYH9 NEDD4L SNRNP200 XRCC6 NEDD4

4.69e-04348385int:FBP1
InteractionTNK2 interactions

MYH9 MERTK NEDD4L NEDD4

4.85e-04195384int:TNK2
InteractionWBP2 interactions

NEDD4L UBE3A NEDD4

4.94e-0482383int:WBP2
InteractionPRX interactions

AHNAK PRX

5.20e-0418382int:PRX
InteractionTMEM174 interactions

NEDD4L NEDD4

5.20e-0418382int:TMEM174
InteractionRASL11B interactions

NEDD4L NEDD4

5.80e-0419382int:RASL11B
InteractionCALCA interactions

PHF1 CALCR

5.80e-0419382int:CALCA
InteractionSP1 interactions

GATA6 MYH9 MYH11 SOX8 NEDD4L

5.82e-04365385int:SP1
InteractionPSMD4 interactions

MYH9 NEDD4L UBE3A XRCC6 NEDD4

6.04e-04368385int:PSMD4
InteractionFGD5 interactions

MYH9 MYH11 XRCC6 AHNAK

6.07e-04207384int:FGD5
InteractionYWHAZ interactions

RICTOR MYH9 SPIRE2 MYH11 SORBS2 NEDD4L UBE3A XRCC6 NEDD4

6.19e-041319389int:YWHAZ
InteractionDAPK3 interactions

MYH9 NEDD4L UBE3A

6.28e-0489383int:DAPK3
InteractionSCN8A interactions

NEDD4L NEDD4

6.44e-0420382int:SCN8A
InteractionCLIC2 interactions

NEDD4L NEDD4

6.44e-0420382int:CLIC2
InteractionUBE2L3 interactions

UBA6 NEDD4L UBE3A NEDD4

6.52e-04211384int:UBE2L3
InteractionDUX4 interactions

MYH9 SNRNP200 XRCC6 AHNAK

6.88e-04214384int:DUX4
InteractionSCN9A interactions

NEDD4L NEDD4

7.11e-0421382int:SCN9A
InteractionKCNQ1 interactions

NEDD4L NEDD4

7.11e-0421382int:KCNQ1
InteractionHAT1 interactions

PHF1 RICTOR UBE3A XRCC6

7.24e-04217384int:HAT1
InteractionAMOTL1 interactions

MRPS35 NEDD4L NEDD4

7.60e-0495383int:AMOTL1
InteractionSUMO2 interactions

MERTK LEF1 SNRNP200 XRCC6 AHNAK NEDD4

7.70e-04591386int:SUMO2
InteractionSLC22A8 interactions

NEDD4L NEDD4

7.81e-0422382int:SLC22A8
InteractionSCNN1G interactions

NEDD4L NEDD4

7.81e-0422382int:SCNN1G
InteractionYAP1 interactions

MYH9 MYH11 POTEJ NEDD4L SNRNP200 XRCC6 AHNAK NEDD4

8.42e-041095388int:YAP1
InteractionYWHAH interactions

RICTOR SPIRE2 MYH11 SORBS2 NEDD4L UBE3A AHNAK NEDD4

8.77e-041102388int:YWHAH
GeneFamilyGATA zinc finger domain containing|Myb/SANT domain containing

GATA6 GATA5

2.76e-041530282
GeneFamilyMyosin heavy chains

MYH9 MYH11

2.76e-04153021098
GeneFamilyGlycosyltransferase family 6|Blood group antigens

B3GALNT1 FUT3

1.71e-0337302454
CoexpressionGSE5542_UNTREATED_VS_IFNA_TREATED_EPITHELIAL_CELLS_24H_UP

MYH9 GTDC1 F2R SNRNP200 AHNAK

1.15e-05200395M6524
CoexpressionSWEET_LUNG_CANCER_KRAS_DN

CXCL14 MYH11 CALCR AHNAK PRX SCN7A

3.50e-05422396M7396
CoexpressionSWEET_LUNG_CANCER_KRAS_DN

CXCL14 MYH11 CALCR AHNAK PRX SCN7A

4.64e-05444396MM1051
CoexpressionAtlasDevelopingKidney_e15.5_ureter tip_flank cortic collct_emap-27752_k-means-cluster#2_top-relative-expression-ranked_1000

CXCL14 SORBS2 PUS3 UBE3A

4.88e-05110394gudmap_developingKidney_e15.5_ureter tip_flank cortic collct_1000_k2
CoexpressionAtlasDevelopingLowerUrinaryTract_P2_bladder stroma (LCM)_emap-30396_top-relative-expression-ranked_500

CXCL14 MYH11 SLC44A1 GATA5 SOX8 SCN7A

6.92e-05387396gudmap_developingLowerUrinaryTract_P2_bladder stroma (LCM)_500
CoexpressionAtlasDevelopingLowerUrinaryTract_P2_bladder stroma (LCM)_emap-30396_top-relative-expression-ranked_1000

CXCL14 RICTOR MYH11 SLC44A1 GATA5 SOX8 AHNAK SCN7A

7.35e-05783398gudmap_developingLowerUrinaryTract_P2_bladder stroma (LCM)_1000
CoexpressionAtlasDevelopingKidney_e15.5_ureter tip_flank cortic collct_emap-27752_k-means-cluster#4_top-relative-expression-ranked_100

CXCL14 SORBS2

9.14e-058392gudmap_developingKidney_e15.5_ureter tip_flank cortic collct_100_k4
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ bladder_emap-6668_top-relative-expression-ranked_500

GATA6 UBA6 MYH11 GATA5 UBE3A SCN7A

1.11e-04422396DevelopingLowerUrinaryTract_e14.5_ bladder_emap-6668_500
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CXCL14 CALCR IL1RAPL2 L3MBTL4 SCN7A

4.86e-07179395c7afbd10072d36a35cd20ae73670d76b9cefd22d
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MYH11 GATA5 F2R IL1RAPL2 SCN7A

5.14e-071813959c157de9d3403e092c907599f2a2c16db5b21131
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MYH11 GATA5 F2R IL1RAPL2 SCN7A

5.14e-07181395eea943fdcbef0bbaa8578f3296923e874893b405
ToppCelldroplet-Lung-nan-21m-Mesenchymal-Myofibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

B3GALNT1 SLC6A7 MYH11 GATA5 SOX8

5.42e-07183395b153425ab0df1e5fa9b953e1f6d4e8e3dc6621b0
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MYH11 GATA5 F2R IL1RAPL2 SCN7A

5.42e-07183395bc7dd6a40ec9c773d005c1a46f305d40cdd0a326
ToppCelldroplet-Lung-nan-21m-Mesenchymal-pulmonary_interstitial_fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

B3GALNT1 SLC6A7 MYH11 GATA5 SOX8

5.42e-0718339519e7be1cfdd111bfb840532a6f7c780345dffccf
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_myocytic|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

CXCL14 MYH9 MYH11 LEF1 L3MBTL4

6.36e-07189395b6d5dec55bf352f6ae19d8f488ae70aa10fb9a8f
ToppCell18-Airway-Mesenchymal-Airway_Smooth_Muscle|Airway / Age, Tissue, Lineage and Cell class

CXCL14 MYH11 GATA5 F2R LEF1

6.70e-0719139586ce98d2c90c196474b06869de888cf5d1eed196
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_myocytic|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

CXCL14 MYH9 MYH11 F2R LEF1

7.05e-07193395000b9e6a819b94ea2e6e9173daf97ba9ac2b6cc6
ToppCellRA-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

MYH9 MYH11 SORBS2 NEDD4L L3MBTL4

7.23e-0719439589812fb164065041357bb37a3c2d87028ec3de4e
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_myocytic|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

CXCL14 MYH9 MYH11 F2R LEF1

7.23e-0719439567f5e2f05a8de2213ab80d5ea16fdee121684633
ToppCell18-Distal-Mesenchymal-Airway_Smooth_Muscle|Distal / Age, Tissue, Lineage and Cell class

CXCL14 MYH11 GATA5 F2R LEF1

8.20e-071993959dd130c041beaa319727f9d22b3f45ba0da49487
ToppCellLA-16._Neuronal|World / Chamber and Cluster_Paper

IL1RAPL2 AHNAK PRX SCN7A

1.39e-051683942fd1fd2a16ac1c5eb028f93cc3a2477c7747693e
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CXCL14 GATA5 SERPINI2 SCN7A

1.39e-05168394fc80e4fecfc92458eb627013a983041d8ca025a9
ToppCellLA-16._Neuronal|LA / Chamber and Cluster_Paper

IL1RAPL2 AHNAK PRX SCN7A

1.39e-05168394c55bbfbde8bb954f1cb9af82007bdd1f8070fee3
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CXCL14 GATA5 SERPINI2 SCN7A

1.39e-05168394e96859dbf51cf8c4def8ee8db132f4d874fb4381
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SLC6A7 MYH11 SORBS2 GATA5

1.49e-0517139482de2885c8ce4fb7776da6a0207b3355c0910121
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SLC6A7 MYH11 SORBS2 GATA5

1.49e-0517139409e653973962fb884878089d281f0947f7a285f6
ToppCellChildren_(3_yrs)-Mesenchymal-myofibroblast_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

CXCL14 MYH11 GATA5 F2R

1.56e-051733941f16d47f5548e257e4b17f8070c5619780a9c5fd
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-epithelial_progenitor_cell-Proximal_progenitor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GATA6 SPIRE2 SORBS2 GATA5

1.64e-051753946759d200a133034756de9cdf2d5daceca927aac9
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1_PAX6_CA4|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CXCL14 IL1RAPL2 L3MBTL4 SCN7A

1.75e-05178394e86ed30652c2de70f16430f04b78789b87df4af2
ToppCellChildren_(3_yrs)-Mesenchymal-myofibroblast_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

CXCL14 MYH11 F2R SCN7A

1.83e-0518039401f2e5d96016823482f89ba503d007d4bd88eeac
ToppCellCOVID-19-Endothelial_cells-Capillary_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

B3GALNT1 NEDD4L PRX NEDD4

1.87e-05181394c5f9c92af1384d9089c65afdf41c6feb8345a3ae
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CXCL14 IL1RAPL2 L3MBTL4 SCN7A

2.03e-05185394487fa382232564f075960899d50afa0edae5d258
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

CXCL14 MYH11 F2R LEF1

2.12e-05187394387cb27c8a20031cd87381a9e1172f1f62e1488b
ToppCellFetal_29-31_weeks-Mesenchymal-myofibroblast_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CXCL14 MYH11 F2R LEF1

2.12e-05187394c104fbfef2d0bef64077ac721edf2379fd59d547
ToppCellLA-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

MYH9 SORBS2 NEDD4L L3MBTL4

2.17e-051883946d249fe92d51a19da19ec14bb2262d394255d577
ToppCellControl-Endothelial-VE_Capillary_A|Endothelial / Disease state, Lineage and Cell class

B3GALNT1 MYH9 NEDD4L PRX

2.17e-0518839488b3415e33db81726dd29c1f50c886e057af50a0
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

CXCL14 MYH11 IL1RAPL2 L3MBTL4

2.17e-0518839474f7d216209cabdc96b2d46685b0ae017fdcc8fc
ToppCelldroplet-Lung-21m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

B3GALNT1 SLC6A7 MYH11 GATA5

2.21e-05189394cd42ce4aa217d0bd95e0cc0ba357bdfeb3e55a48
ToppCelldroplet-Lung-21m-Mesenchymal-myofibroblast-myofibroblast_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

B3GALNT1 SLC6A7 MYH11 GATA5

2.21e-05189394102501eee7760d5882dec41ea9d00147b3f4fb73
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_myocytic|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

CXCL14 MYH9 MYH11 LEF1

2.21e-05189394f75cebd4c3e54e297557449ba67ccc8d1a2a14f5
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

CXCL14 MYH11 F2R LEF1

2.21e-051893940abc7a4900cc9033bc1be69b770ccc54a6bf41b4
ToppCelldroplet-Lung-21m-Mesenchymal-myofibroblast|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

B3GALNT1 SLC6A7 MYH11 GATA5

2.21e-051893946e83bf855d4771885b60bb8992df2f9b508eef97
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_1|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

CXCL14 MYH11 F2R LEF1

2.26e-05190394d24af6af3271e34afab744352afd28be8a7cc5c3
ToppCellAdult-Epithelial-club_cell|Adult / Lineage, Cell type, age group and donor

SORBS2 NEDD4L DNAH5 L3MBTL4

2.26e-05190394756bff697d30aec56c0ebfca94295f084a15bf37
ToppCellLPS-IL1RA-Endothelial-Endothelial-Artery|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GATA6 SORBS2 MERTK F2R

2.26e-05190394aed65d584ca0c25f6a8313c66b421a6618af82ea
ToppCellwk_08-11-Mesenchymal-Myofibro_&_SMC-Myofibro_1|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

CXCL14 MYH11 F2R LEF1

2.26e-0519039471a00f63fdd4eb4cc6f190d37e7a0417cdaafacb
ToppCellPND10|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MYH9 MYH11 AHNAK SCN7A

2.26e-05190394d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCellfacs-Lung-3m-Mesenchymal-myofibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

B3GALNT1 MYH11 GATA5 F2R

2.30e-05191394fd8331c7abdd999f55ba43d307945c6abfccbf84
ToppCellILEUM-non-inflamed|ILEUM / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

CCNH CXCL14 AHNAK SCN7A

2.30e-05191394c4a78ef7b87ffadbb1b9b69cbfa7c164ca456f9a
ToppCellwk_08-11-Mesenchymal-Myofibro_&_SMC-Early_airway_SMC_1|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

CXCL14 MYH11 F2R LEF1

2.35e-051923947ae3e1ca8bfc078c0e12a1595ecb0e343dab5d2f
ToppCellwk_20-22-Mesenchymal-Myofibro_&_SMC-Myofibro_2|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

CXCL14 MYH11 F2R LEF1

2.40e-051933942f203f6f0c2135acb046c9351a633c3b5b254a46
ToppCellMesenchymal_cells-Stromal_fibro.|World / Lineage and Cell class

B3GALNT1 SOX8 AHNAK SCN7A

2.50e-0519539469723b06c2a5c2aaf4d10874b11bca7f06822bdc
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-T_lymphocytic-CD8-positive,_alpha-beta_cytotoxic_T_cell|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

GATA6 MYH9 F2R AHNAK

2.50e-05195394730c613cf6f4d16ca51fd44de1f5a883f615c5c5
ToppCell15-Distal-Mesenchymal|Distal / Age, Tissue, Lineage and Cell class

CXCL14 MYH11 GATA5 SCN7A

2.55e-05196394b8d95b5f4780e73d16dcc528e70a5496f0314373
ToppCell15-Distal-Mesenchymal-Airway_Smooth_Muscle|Distal / Age, Tissue, Lineage and Cell class

CXCL14 MYH11 F2R LEF1

2.55e-051963940e45817625b96d21a8cc4dfbbd465ee6403b6802
ToppCellPND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MYH9 MYH11 F2R LEF1

2.55e-051963946708026bafd19c35c5c4e81911344d36a0f508cd
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-skeletal_muscle_satellite_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NEDD4L CALCR F2R NEDD4

2.60e-051973945bc11aff92da2a0aca8473f997fe7a99f3cae75d
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CXCL14 F2R DNAH5 LEF1

2.60e-051973942e3d64648a1e4f01b9256a96b94b8a640ee1824c
ToppCell10x5'-Liver-Lymphocytic_T_CD4|Liver / Manually curated celltypes from each tissue

CCNH MYH9 LEF1 AHNAK

2.60e-051973944891111894b741555f549deec6af8006376d9358
ToppCellproximal-3-Endothelial-Artery|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SOX8 TP53TG5 F2R PRX

2.65e-05198394946f72b594d22ae7b8e4c22483814c284cb43eea
ToppCellfacs-Tongue-nan-3m-Epithelial-basal_cell_of_epidermis|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH9 F2R AHNAK NEDD4

2.65e-0519839422559b161e67b49fe8028bfaf861e069063599f5
ToppCellproximal-Endothelial-Artery|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SOX8 TP53TG5 F2R PRX

2.65e-051983940e5572298676b6c2a2b1a77967574020b664aebd
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CXCL14 F2R DNAH5 LEF1

2.65e-051983944a4566f86c9365a41b4cfd1609eac09bd73b3f34
ToppCellTracheal-10x3prime_v2-Stromal-Fibroblastic-Fibro_myofibroblast|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

MYH11 GATA5 F2R SCN7A

2.65e-0519839408d393853e195a7eacace454153e425a273e2d23
ToppCellproximal-Endothelial-Artery-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SOX8 TP53TG5 F2R PRX

2.65e-05198394a56b80bdc824e4cc60366f273fb616cd0efec456
ToppCellSkin-Mesangial|Skin / Skin and Kidney Cells in Lupus Nephritis Patients.

SLC6A7 MYH11 SORBS2 TP53TG5

2.71e-05199394bcb78838a91cc7828680fb413fbacdb091c5fac0
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CXCL14 MYH11 F2R AHNAK

2.71e-051993943d8c76e3d05acf72a35ca755b51579fc3ae63562
ToppCell11.5-Airway-Mesenchymal-Airway_Smooth_Muscle|Airway / Age, Tissue, Lineage and Cell class

CXCL14 MYH11 F2R LEF1

2.71e-051993941a8c77d241bd817a195e1532fd25f51358cb1ff1
ToppCell10x_5'_v1-Non-neoplastic|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CCNH MYH9 F2R AHNAK

2.76e-0520039488e94b067da1068b2ff1f95c730f2a49c66d7fe6
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6|Neuronal / cells hierarchy compared to all cells using T-Statistic

CXCL14 IL1RAPL2 L3MBTL4 SCN7A

2.76e-052003948a8f9d9e5ffab3f736c4bd0a5bb616d442d137d1
ToppCellParenchymal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

MYH11 TP53TG5 GTDC1 LEF1

2.76e-05200394a372ef3f9e6ff6e3c3376d6e10182977c5067788
ToppCellE18.5-samps-Epithelial-Alveolar_epithelial-Uncommitted_AE_Progenitor|E18.5-samps / Age Group, Lineage, Cell class and subclass

GATA6 PHF1 NEDD4L

1.70e-041233935f002f5180fe47fe57ab888b5f0319df99ab2c59
ToppCellBronchial_Biopsy-Mesenchymal-Fibroblasts|Mesenchymal / Tissue, Lineage and Cell class of Lung Cells from 10X

CXCL14 F2R SCN7A

1.95e-0412939313cd10ffdd8f1ef7721884e9efd2cf25f170f414
ToppCellRA-06._Ventricular_Cardiomyocyte_II|World / Chamber and Cluster_Paper

CCDC168 SORBS2 SERPINI2

2.23e-041353936121b1d30d05b7d476661b932f51191da09dfeeb
ToppCellRV-16._Neuronal|World / Chamber and Cluster_Paper

IL1RAPL2 AHNAK SCN7A

2.98e-041493933a2f8c4173dcf9e3f8d3b8ffddbc597098adf7a9
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-3|TCGA-Brain / Sample_Type by Project: Shred V9

RICTOR CCDC168 FUT3

2.98e-04149393768877bade04ca0321593b8470b5011ad8270431
ToppCellCOVID-19-Epithelial_cells-Airway_mucous|COVID-19 / group, cell type (main and fine annotations)

SERPINI2 NEDD4L DNAH5

3.10e-041513938216462e723fec2797387929dde095370947e10a
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH11 DNAH5 AHNAK

3.16e-04152393d5ba87b5d34e52cef8475befafea962d70fa8a1d
ToppCelldroplet-Liver-LIVER_HEPATOCYTES|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH11 DNAH5 AHNAK

3.16e-04152393d88d68a788a3256671ebbc06e104833f1f58f07d
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lect1_Oxtr|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CXCL14 AHNAK SCN7A

3.35e-0415539399e749f7075e2c64e9a0bf91009f95b6969197c8
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_2|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

CXCL14 MYH11 F2R

3.47e-04157393b9d04ee417c0d8ea0801d10f1c54e138587009fd
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-Z|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

MYH9 CCDC168 AHNAK

3.60e-04159393bf8ff9251bcb64b2b9d6dd93461aec97659686ec
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NEDD4L CALCR LEF1

3.67e-041603931e210e526ea4d84fc58a798a26c0929bcb69fd89
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Neural-neural_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SOX8 IL1RAPL2 SCN7A

3.81e-04162393d28b2ea1d2c8f3c6a107991573471b6d0c49c4ae
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mast-Mast|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

GATA6 CALCR AHNAK

3.81e-0416239330508c4007faa38b76246e3c6d7b3fde4492cc85
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mast|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

GATA6 CALCR AHNAK

3.81e-0416239333b73c6727b5c5ada2dddf304f56d84397725ca8
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SOX8 IL1RAPL2 SCN7A

3.81e-041623935bbd7130d4dad9035e73a439dda568195c136f31
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PHF1 CCNH LEF1

3.81e-0416239380317c4253bf8e897782e562f29835f181c65b98
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SOX8 IL1RAPL2 SCN7A

3.81e-04162393eed223e61c8162a2fe004ab4e09de5e037be7553
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mast-Mast-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

GATA6 CALCR AHNAK

3.81e-0416239344ef0932ee38964ff11edc2aa14698d9db3b2b6b
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Neural|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SOX8 IL1RAPL2 SCN7A

3.81e-04162393e35ddce830e20ebeac1a2c405293fc4a5323dd4a
ToppCellInfluenza_Severe-NK_CD56bright|Influenza_Severe / Disease group and Cell class

LEF1 PRX L3MBTL4

3.88e-041633937748d5709e8cf6673f5a8370108309f76cd830f4
ToppCellChildren_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

SLC6A7 MYH11 GATA5

3.95e-04164393e3983f655cdba308fb192182829f17bef99ce0ba
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

B3GALNT1 IL1RAPL2 SCN7A

3.95e-04164393d167c7a987b9b35d1e7725c803df4f9cd5380e47
ToppCell15-Airway-Mesenchymal-Airway_Smooth_Muscle|Airway / Age, Tissue, Lineage and Cell class

MYH11 GATA5 L3MBTL4

4.02e-04165393531804467601e1ee1f771cffa21501f6d464ae10
ToppCell3'-GW_trimst-2-SmallIntestine-Epithelial-Tuft-related-Tuft|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RICTOR GATA5 FUT3

4.02e-0416539334fd00be2b28716c871ad9fb356de84a299a0c01
ToppCellLV-13._Vascular_Smooth_Muscle|World / Chamber and Cluster_Paper

MYH11 SORBS2 IL1RAPL2

4.02e-04165393f37fd95adc95d7753cf6e55ae819976513c7ec77
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Lymphocytic|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH11 GATA5 AHNAK

4.16e-04167393e1b1a952fce27ab9cf16919b290625ff4a75261e
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

MYH11 LEF1 AHNAK

4.16e-04167393ced6ed9b412739c6ced622523347c10295edbf53
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CXCL14 GATA5 SERPINI2

4.23e-04168393315ca578c945aeeb77acda2727f3e6db8b43f43e
ToppCelldroplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SLC6A7 CXCL14 SCN7A

4.23e-04168393d2b91f2adc95dcfa623f8d7ca2df1c6f884da988
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NEDD4L CALCR L3MBTL4

4.31e-041693934b3a7b4a497178799b6b2f0b744f5fb752cee31a
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NEDD4L CALCR L3MBTL4

4.31e-04169393a4fd646b9bf87225131fca530bd6b52df9eaf489
ToppCell390C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

B3GALNT1 NEDD4L PRX

4.38e-04170393a6fa0cab1fa829ec601fe48306b4c43c83425b04
ToppCell390C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

B3GALNT1 NEDD4L PRX

4.38e-04170393b40255eee45eb18b5a297336d7f3845fd8f8aa3b
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

GATA6 NEDD4L L3MBTL4

4.38e-04170393a2c738e441ced90eeeb1fcc6ca3269b918aaa298
ToppCell368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

B3GALNT1 NEDD4L PRX

4.38e-04170393f0b0d2d0402de3ed7322284a599646db43475761
ToppCell368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

B3GALNT1 NEDD4L PRX

4.38e-04170393054360a3b05f5e41221c98b122d241b1affad26a
DiseaseLiddle syndrome (implicated_via_orthology)

NEDD4L NEDD4

9.67e-064382DOID:0050477 (implicated_via_orthology)
Diseasetetralogy of Fallot (is_implicated_in)

GATA6 GATA5

1.25e-0413382DOID:6419 (is_implicated_in)
DiseaseFEV/FEC ratio

ZNF438 GATA6 PHF1 MRPS35 MYH9 GATA5 TP53TG5 DNAH5

1.41e-041228388EFO_0004713
Diseaseventricular septal defect (is_implicated_in)

GATA6 GATA5

1.46e-0414382DOID:1657 (is_implicated_in)
DiseaseTetralogy of Fallot

GATA6 GATA5

1.92e-0416382C0039685
DiseaseATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)

GATA6 GATA5

3.67e-0422382C1843687
Diseaselower urinary tract symptom, benign prostatic hyperplasia

GATA6 GATA5

7.82e-0432382EFO_0000284, EFO_0008008
Diseasemultiple sclerosis

ZNF438 SOX8 MERTK GTDC1 LEF1

9.42e-04594385MONDO_0005301
DiseaseNeoplasm Invasiveness

MYH9 LEF1 AHNAK

1.71e-03184383C0027626
DiseaseFamilial thoracic aortic aneurysm and aortic dissection

MYH11 GATA5

2.14e-0353382C4707243
Diseasefactor VII measurement

L3MBTL4 NEDD4

2.30e-0355382EFO_0004619
DiseaseMalignant neoplasm of breast

ZNF438 CCNH MYH9 LEF1 IL1RAPL2 NEDD4

2.33e-031074386C0006142

Protein segments in the cluster

PeptideGeneStartEntry
IMKSMRNLVKKYEPP

CCNH

251

P51946
PKPFLYVVGRKKMMD

CALCR

36

P30988
FKMPDLHLKAPKISM

AHNAK

4581

Q09666
RPHIKKPLNAFMLYM

LEF1

296

Q9UJU2
IRPFYKMMLHKPITL

NEDD4

1076

P46934
KPMVILPFMKYGDLH

MERTK

666

Q12866
PRIYEMMGHVKPIKF

B3GALNT1

251

O75752
KVFKMRLPHGFLPNM

L3MBTL4

286

Q8NA19
EMYKGKKRHEMPPHI

MYH9

136

P35579
LKRFHEMKKRGPKPY

RICTOR

476

Q6R327
MKPKYPHCEEKMVII

CXCL14

56

O95715
MKVKKPAVVYMLHLA

F2R

131

P25116
MKLHGVPRPLAMKKE

GATA5

271

Q9BWX5
YMKLHGVPRPLAMKK

GATA6

471

Q92908
PRMILMYIHSQLKGK

SLC44A1

456

Q8WWI5
MKVKKPAISLMPYIN

CCDC168

1091

Q8NDH2
SMGKFMKLIPDHRPK

GTDC1

136

Q4AE62
MTKIKMLPTPAKFHY

DNAH5

2776

Q8TE73
LKKGPYARAMLGMKL

PHF1

151

O43189
VYGRSHKPLPKGTMM

FUT3

221

P21217
RMGYPVKKGVPMAKE

MRPS35

86

P82673
VKMRTYKPLMDRPKC

PUS3

406

Q9BZE2
HLVYEMPIKKKEMLP

IL1RAPL2

551

Q9NP60
SMMKIRIIAPPKRKY

POTEJ

986

P0CG39
LKAKPHVKRPMNAFM

SOX8

96

P57073
APGFLKMYKKMHRIN

SORBS2

446

O94875
PKPLMVHMRKYGGIT

SLC6A7

601

Q99884
MYKGKKRHEMPPHIY

MYH11

141

P35749
FIKPYRNRTPMGHMK

TP53TG5

186

Q9Y2B4
KMLYVPVMPGHAKRL

UBA6

991

A0AVT1
MLMGFKPLVLLKKHH

XRCC6

346

P12956
VHFPMVVYRKLMGKK

UBE3A

631

Q05086
IKMKMPSKKFGHIPV

SPIRE2

601

Q8WWL2
VKMPKLKMPSFGLAR

PRX

1056

Q9BXM0
VKIPMMKALLRTKYG

SERPINI2

211

O75830
RMPKMGKTIHKYVHL

SNRNP200

1166

O75643
KGPKVFHNLMLPLML

SCN7A

1361

Q01118
KKYRSIMPKPIMVIP

ZNF438

431

Q7Z4V0
RVKGFLRLKMAYMPK

NEDD4L

141

Q96PU5