Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioninterleukin-28 receptor binding

IFNL2 IFNL3 IFNL1

1.11e-073973GO:0032003
GeneOntologyBiologicalProcesscellular response to type III interferon

IFNL2 IFNL3 IFNL1

1.57e-0511963GO:0071358
GeneOntologyBiologicalProcesstype III interferon-mediated signaling pathway

IFNL2 IFNL3 IFNL1

1.57e-0511963GO:0038196
GeneOntologyBiologicalProcessresponse to type III interferon

IFNL2 IFNL3 IFNL1

2.70e-0513963GO:0034342
GeneOntologyCellularComponentinterleukin-28 receptor complex

IFNL2 IFNL3 IFNL1

9.32e-075963GO:0032002
DomainINF_lambda

IFNL2 IFNL3 IFNL1

5.08e-074953IPR029177
DomainIL28A

IFNL2 IFNL3 IFNL1

5.08e-074953PF15177
DomainHIF-1a_CTAD

HIF1A EPAS1

2.56e-052952PF08778
DomainFNIP_N_dom

FNIP2 FNIP1

2.56e-052952IPR028084
DomainFNIP_mid_dom

FNIP2 FNIP1

2.56e-052952IPR028085
DomainFNIP_C_dom

FNIP2 FNIP1

2.56e-052952IPR028086
DomainFNIP_C

FNIP2 FNIP1

2.56e-052952PF14638
DomainFNIP_M

FNIP2 FNIP1

2.56e-052952PF14637
DomainFNIP_N

FNIP2 FNIP1

2.56e-052952PF14636
DomainFNIP_fam

FNIP2 FNIP1

2.56e-052952IPR026156
DomainHIF-1_TAD_C

HIF1A EPAS1

2.56e-052952IPR014887
DomainHIF_alpha_subunit

HIF1A EPAS1

7.65e-053952IPR021537
DomainHIF-1

HIF1A EPAS1

7.65e-053952PF11413
DomainPIN_dom

NOB1 DIS3

3.79e-046952IPR002716
DomainPINc

NOB1 DIS3

3.79e-046952SM00670
PathwayWP_TYPE_III_INTERFERON_SIGNALING

IFNL2 IFNL3 IFNL1

1.37e-0510703M39464
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

VWA5B2 EPPK1 HIVEP2 MYO10 RPS6KA2 NOB1 POLRMT SLC10A3 HUWE1 BCR TRRAP RYR1 HIVEP3 FASN C2CD3 RPAP1 KCNJ11 DEF6 PKN1 PC

3.03e-111105982035748872
Pubmed

Interferon-λs: special immunomodulatory agents and potential therapeutic targets.

IFNL2 IFNL3 IFNL1

2.17e-08398323207147
Pubmed

Interferon lambda 2 promotes mammary tumor metastasis via angiogenesis extension and stimulation of cancer cell migration.

IFNL2 IFNL3 IFNL1

2.17e-08398329151074
Pubmed

Murine interferon lambdas (type III interferons) exhibit potent antiviral activity in vivo in a poxvirus infection model.

IFNL2 IFNL3 IFNL1

2.17e-08398315914836
Pubmed

Full house: 12 receptors for 27 cytokines.

IFNL2 IFNL3 IFNL1

2.17e-08398315120645
Pubmed

Genetic polymorphisms of the IFNλ genes are associated with biochemical features in Han Chinese with HCV infection from Yunnan Province, China.

IFNL2 IFNL3 IFNL1

2.17e-08398324269996
Pubmed

Liposome-mediated IL-28 and IL-29 expression in A549 cells and anti-viral effect of IL-28 and IL-29 on WISH cells.

IFNL2 IFNL3 IFNL1

2.17e-08398316539846
Pubmed

Interferon-lambda serum levels in hepatitis C.

IFNL2 IFNL3 IFNL1

2.17e-08398321145813
Pubmed

IFN-λ Decreases Murid Herpesvirus-4 Infection of the Olfactory Epithelium but Fails to Prevent Virus Reactivation in the Vaginal Mucosa.

IFNL2 IFNL3 IFNL1

2.17e-08398331426334
Pubmed

Interleukin 28A aggravates Con A-induced acute liver injury by promoting the recruitment of M1 macrophages.

IFNL2 IFNL3 IFNL1

2.17e-08398338265281
Pubmed

Interferon-lambda-treated dendritic cells specifically induce proliferation of FOXP3-expressing suppressor T cells.

IFNL2 IFNL3 IFNL1

2.17e-08398316478884
Pubmed

Impact and regulation of lambda interferon response in human metapneumovirus infection.

IFNL2 IFNL3 IFNL1

2.17e-08398325355870
Pubmed

Type III interferon attenuates a vesicular stomatitis virus-based vaccine vector.

IFNL2 IFNL3 IFNL1

2.17e-08398325008938
Pubmed

Interleukin-28A enhances autoimmune disease in a retinal autoimmunity model.

IFNL2 IFNL3 IFNL1

2.17e-08398325138017
Pubmed

Induction of interferon lambda in influenza a virus infected cells treated with shRNAs against M1 transcript.

IFNL2 IFNL3 IFNL1

2.17e-08398326104331
Pubmed

Interferon-lambdas: the modulators of antivirus, antitumor, and immune responses.

IFNL2 IFNL3 IFNL1

2.17e-08398319304895
Pubmed

Interferon Lambda Upregulates IDO1 Expression in Respiratory Epithelial Cells After Influenza Virus Infection.

IFNL2 IFNL3 IFNL1

8.66e-08498325756191
Pubmed

IFN-λ resolves inflammation via suppression of neutrophil infiltration and IL-1β production.

IFNL2 IFNL3 IFNL1

8.66e-08498325941255
Pubmed

Guarding the frontiers: the biology of type III interferons.

IFNL2 IFNL3 IFNL1

8.66e-08498326194286
Pubmed

Nasally delivered interferon-λ protects mice against infection by SARS-CoV-2 variants including Omicron.

IFNL2 IFNL3 IFNL1

8.66e-08498335523172
Pubmed

Disruption of Type III Interferon (IFN) Genes Ifnl2 and Ifnl3 Recapitulates Loss of the Type III IFN Receptor in the Mucosal Antiviral Response.

IFNL2 IFNL3 IFNL1

8.66e-08498331462571
Pubmed

IFNalpha and IFNlambda differ in their antiproliferative effects and duration of JAK/STAT signaling activity.

IFNL2 IFNL3 IFNL1

8.66e-08498318698163
Pubmed

Characterization of the mouse IFN-lambda ligand-receptor system: IFN-lambdas exhibit antitumor activity against B16 melanoma.

IFNL2 IFNL3 IFNL1

8.66e-08498316618774
Pubmed

IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex.

IFNL2 IFNL3 IFNL1

2.16e-07598312483210
Pubmed

Type III interferons disrupt the lung epithelial barrier upon viral recognition.

IFNL2 IFNL3 IFNL1

2.16e-07598332527925
Pubmed

IPS-1 is essential for type III IFN production by hepatocytes and dendritic cells in response to hepatitis C virus infection.

IFNL2 IFNL3 IFNL1

2.16e-07598324532585
Pubmed

IFN-lambda determines the intestinal epithelial antiviral host defense.

IFNL2 IFNL3 IFNL1

2.16e-07598321518880
Pubmed

Gestational Stage and IFN-λ Signaling Regulate ZIKV Infection In Utero.

IFNL2 IFNL3 IFNL1

2.16e-07598328910635
Pubmed

IL-28, IL-29 and their class II cytokine receptor IL-28R.

IFNL2 IFNL3 IFNL1

2.16e-07598312469119
Pubmed

HIFα Regulates Developmental Myelination Independent of Autocrine Wnt Signaling.

HIF1A WLS EPAS1

4.31e-07698333208471
Pubmed

Interferon-λ Mediates Non-redundant Front-Line Antiviral Protection against Influenza Virus Infection without Compromising Host Fitness.

IFNL2 IFNL3 IFNL1

4.31e-07698328514692
Pubmed

Activation of Epithelial Signal Transducer and Activator of Transcription 1 by Interleukin 28 Controls Mucosal Healing in Mice With Colitis and Is Increased in Mucosa of Patients With Inflammatory Bowel Disease.

IFNL2 IFNL3 IFNL1

4.31e-07698328342759
Pubmed

Transcriptional regulation of IFN-λ genes in hepatitis C virus-infected hepatocytes via IRF-3·IRF-7·NF-κB complex.

IFNL2 IFNL3 IFNL1

4.31e-07698324385435
Pubmed

Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia.

CACNA1C HLA-E TRANK1

7.53e-07798324280982
Pubmed

A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis.

IFNL2 IFNL3 IFNL1

1.20e-06898331130511
Pubmed

Glial type specific regulation of CNS angiogenesis by HIFα-activated different signaling pathways.

HIF1A WLS EPAS1

1.20e-06898332332719
Pubmed

The TIP60 Complex Is a Conserved Coactivator of HIF1A.

HIF1A POLRMT SAMHD1 TRRAP IQGAP1 FASN

1.21e-0612098627320910
Pubmed

Interaction between von Hippel-Lindau Protein and Fatty Acid Synthase Modulates Hypoxia Target Gene Expression.

HIF1A FASN EPAS1

1.80e-06998328775317
Pubmed

IFN-λ derived from nonsusceptible enterocytes acts on tuft cells to limit persistent norovirus.

IFNL2 IFNL3 IFNL1

3.52e-061198337703370
Pubmed

Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection.

IFNL2 IFNL3 IFNL1

3.52e-061198326006013
Pubmed

Suppression of HIF2 signalling attenuates the initiation of hypoxia-induced pulmonary hypertension.

HIF1A EPAS1

7.86e-06298231515405
Pubmed

Epigenetic regulation of HIF-1α in renal cancer cells involves HIF-1α/2α binding to a reverse hypoxia-response element.

HIF1A EPAS1

7.86e-06298221841824
Pubmed

A microfluidic oxygen gradient demonstrates differential activation of the hypoxia-regulated transcription factors HIF-1α and HIF-2α.

HIF1A EPAS1

7.86e-06298228840922
Pubmed

ECM-dependent HIF induction directs trophoblast stem cell fate via LIMK1-mediated cytoskeletal rearrangement.

HIF1A EPAS1

7.86e-06298223437279
Pubmed

The Synergistic Effect of Fluvastatin and IFN-λ on Peripheral Blood Mononuclear Cells of Chronic Hepatitis C Virus (HCV) Patients with IL-28B rs12979860 CC Genotype.

IFNL3 IFNL1

7.86e-06298232245297
Pubmed

Lambda interferon inhibits hepatitis B and C virus replication.

IFNL2 IFNL3

7.86e-06298215731279
Pubmed

Neuronal HIF-1α and HIF-2α deficiency improves neuronal survival and sensorimotor function in the early acute phase after ischemic stroke.

HIF1A EPAS1

7.86e-06298226746864
Pubmed

HIF-1α and HIF-2α correlate with migration and invasion in gastric cancer.

HIF1A EPAS1

7.86e-06298220559021
Pubmed

Loss of either hypoxia inducible factor 1 or 2 promotes lung cancer cell colonization.

HIF1A EPAS1

7.86e-06298221610325
Pubmed

Effect of radiation and ibuprofen on normoxic renal carcinoma cells overexpressing hypoxia-inducible factors by loss of von Hippel-Lindau tumor suppressor gene function.

HIF1A EPAS1

7.86e-06298215217953
Pubmed

Constitutive expression of HIF-α plays a major role in generation of clear-cell phenotype in human primary and metastatic renal carcinoma.

HIF1A EPAS1

7.86e-06298225046225
Pubmed

Interleukin-28B dampens airway inflammation through up-regulation of natural killer cell-derived IFN-γ.

IFNL2 IFNL3

7.86e-06298228620197
Pubmed

Association Between IL28B, IL29 Gene Polymorphisms and Clinical Manifestations of Behçet's Disease.

IFNL3 IFNL1

7.86e-06298232646311
Pubmed

The Deubiquitinase USP13 Maintains Cancer Cell Stemness by Promoting FASN Stability in Small Cell Lung Cancer.

USP13 FASN

7.86e-06298235898882
Pubmed

Hypoxia induced HIF-1/HIF-2 activity alters trophoblast transcriptional regulation and promotes invasion.

HIF1A EPAS1

7.86e-06298226531845
Pubmed

Mutation analysis of hypoxia-inducible factors HIF1A and HIF2A in renal cell carcinoma.

HIF1A EPAS1

7.86e-06298220032376
Pubmed

The transition from HIF-1 to HIF-2 during prolonged hypoxia results from reactivation of PHDs and HIF1A mRNA instability.

HIF1A EPAS1

7.86e-06298236482296
Pubmed

Identification of CDCP1 as a hypoxia-inducible factor 2α (HIF-2α) target gene that is associated with survival in clear cell renal cell carcinoma patients.

CDCP1 EPAS1

7.86e-06298223378636
Pubmed

Low oxygen atmosphere facilitates proliferation and maintains undifferentiated state of umbilical cord mesenchymal stem cells in an hypoxia inducible factor-dependent manner.

HIF1A EPAS1

7.86e-06298224726658
Pubmed

Increasing expression of hypoxia-inducible proteins in the Barrett's metaplasia-dysplasia-adenocarcinoma sequence.

HIF1A EPAS1

7.86e-06298217437013
Pubmed

DNA methylation repels binding of hypoxia-inducible transcription factors to maintain tumor immunotolerance.

HIF1A EPAS1

7.86e-06298232718321
Pubmed

Histone deacetylase 3 down-regulates cholesterol synthesis through repression of lanosterol synthase gene expression.

YY1 HDAC3

7.86e-06298217925399
Pubmed

Hypoxia inducible factor: a potential prognostic biomarker in oral squamous cell carcinoma.

HIF1A EPAS1

7.86e-06298226880584
Pubmed

Linkage of Lambda Interferons in Protection Against Severe COVID-19.

IFNL2 IFNL1

7.86e-06298233885337
Pubmed

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

HIF1A EPAS1

7.86e-06298215964822
Pubmed

Localization of immunoreactive HIF-1alpha and HIF-2alpha in neuroendocrine cells of both benign and malignant prostate glands.

HIF1A EPAS1

7.86e-06298217562539
Pubmed

Targeting fatty acid synthase modulates sensitivity of hepatocellular carcinoma to sorafenib via ferroptosis.

HIF1A FASN

7.86e-06298236604718
Pubmed

[Expression of HIF-1alpha mRNA and HIF-2alpha mRNA in placentas of pregnant women with intrahepatic cholestasis of pregnancy].

HIF1A EPAS1

7.86e-06298217718430
Pubmed

Extensive regulation of the non-coding transcriptome by hypoxia: role of HIF in releasing paused RNApol2.

HIF1A EPAS1

7.86e-06298224363272
Pubmed

The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha.

HIF1A EPAS1

7.86e-06298217804822
Pubmed

Uncoupling of growth plate maturation and bone formation in mice lacking both Schnurri-2 and Schnurri-3.

HIVEP2 HIVEP3

7.86e-06298220404140
Pubmed

Hypoxia and the expression of HIF-1alpha and HIF-2alpha in the retina of streptozotocin-injected mice and rats.

HIF1A EPAS1

7.86e-06298220005221
Pubmed

Inherent DNA-binding specificities of the HIF-1α and HIF-2α transcription factors in chromatin.

HIF1A EPAS1

7.86e-06298230429208
Pubmed

HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism.

HIF1A EPAS1

7.86e-06298229176561
Pubmed

Interferon-lambda genotype and low serum low-density lipoprotein cholesterol levels in patients with chronic hepatitis C infection.

IFNL2 IFNL3

7.86e-06298220235331
Pubmed

Murine Type III interferons are functionally redundant and correlate with bacterial burden during influenza/bacterial super-infection.

IFNL2 IFNL3

7.86e-06298234618816
Pubmed

Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex.

HIF1A EPAS1

7.86e-06298212123724
Pubmed

Endothelial HIF-2α as a Key Endogenous Mediator Preventing Emphysema.

HIF1A EPAS1

7.86e-06298232515984
Pubmed

Increased size of solid organs in patients with Chuvash polycythemia and in mice with altered expression of HIF-1alpha and HIF-2alpha.

HIF1A EPAS1

7.86e-06298220140661
Pubmed

Upregulated hypoxia inducible factor-1alpha and -2alpha pathway in rheumatoid arthritis and osteoarthritis.

HIF1A EPAS1

7.86e-06298212823854
Pubmed

The acquired radioresistance in HeLa cells under conditions mimicking hypoxia was attenuated by a decreased expression of HIF subunit genes induced by RNA interference.

HIF1A EPAS1

7.86e-06298225805230
Pubmed

IL-28A (IFN-λ2) modulates lung DC function to promote Th1 immune skewing and suppress allergic airway disease.

IFNL2 IFNL3

7.86e-06298221538995
Pubmed

Roles of hypoxia-inducible factor-1alpha (HIF-1alpha) versus HIF-2alpha in the survival of hepatocellular tumor spheroids.

HIF1A EPAS1

7.86e-06298220513003
Pubmed

Differential regulation of HIF-mediated pathways increases mitochondrial metabolism and ATP production in hypoxic osteoclasts.

HIF1A EPAS1

7.86e-06298223303559
Pubmed

Endothelial deletion of hypoxia-inducible factor-2alpha (HIF-2alpha) alters vascular function and tumor angiogenesis.

HIF1A EPAS1

7.86e-06298219439736
Pubmed

HIF-1α and HIF-2α induced angiogenesis in gastrointestinal vascular malformation and reversed by thalidomide.

HIF1A EPAS1

7.86e-06298227249651
Pubmed

Hepatitis C virus induces interferon-λ and interferon-stimulated genes in primary liver cultures.

IFNL3 IFNL1

7.86e-06298221800339
Pubmed

Differential Contribution of N- and C-Terminal Regions of HIF1α and HIF2α to Their Target Gene Selectivity.

HIF1A EPAS1

7.86e-06298233321829
Pubmed

Differential expression of hypoxia-inducible factors related to the invasiveness of epithelial ovarian cancer.

HIF1A EPAS1

7.86e-06298234824343
Pubmed

Hypoxia Inducible Factors Modify Collagen I Fibers in MDA-MB-231 Triple Negative Breast Cancer Xenografts.

HIF1A EPAS1

7.86e-06298229247885
Pubmed

Oxygen-dependent changes in binding partners and post-translational modifications regulate the abundance and activity of HIF-1α/2α.

HIF1A EPAS1

7.86e-06298234285132
Pubmed

The hypoxia-inducible factors HIF1α and HIF2α are dispensable for embryonic muscle development but essential for postnatal muscle regeneration.

HIF1A EPAS1

7.86e-06298228232488
Pubmed

Hypoxia inducible factor promotes murine allergic airway inflammation and is increased in asthma and rhinitis.

HIF1A EPAS1

7.86e-06298221517900
Pubmed

The Kaposi's Sarcoma-Associated Herpesvirus ORF34 Protein Interacts and Stabilizes HIF-2α via Binding to the HIF-2α bHLH and PAS Domains.

HIF1A EPAS1

7.86e-06298231189709
Pubmed

Biological activity of interleukins-28 and -29: comparison with type I interferons.

IFNL2 IFNL1

7.86e-06298215899585
Pubmed

Neural regulation of hypoxia-inducible factors and redox state drives the pathogenesis of hypertension in a rodent model of sleep apnea.

HIF1A EPAS1

7.86e-06298225953833
Pubmed

HIF1α is necessary for exercise-induced neuroprotection while HIF2α is needed for dopaminergic neuron survival in the substantia nigra pars compacta.

HIF1A EPAS1

7.86e-06298225796140
Pubmed

Impact of HIF-1alpha and HIF-2alpha on proliferation and migration of human pulmonary artery fibroblasts in hypoxia.

HIF1A EPAS1

7.86e-06298216263938
Pubmed

The relation between hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression with anemia and outcome in surgically treated head and neck cancer.

HIF1A EPAS1

7.86e-06298216826581
Pubmed

IFN-λ3 is induced by Leishmania donovani and can inhibit parasite growth in cell line models but not in the mouse model, while it shows a significant association with leishmaniasis in humans.

IFNL2 IFNL3

7.86e-06298238193711
InteractionTOP3B interactions

VWA5B2 EPPK1 HIVEP2 MYO10 RPS6KA2 NOB1 POLRMT SLC10A3 APOB HUWE1 BCR TRRAP RYR1 IQGAP1 HIVEP3 FASN C2CD3 RPAP1 KCNJ11 DEF6 PKN1 PC

9.65e-0714709522int:TOP3B
InteractionCRYBB3 interactions

HAUS5 HDAC3 CRYBB3 RPAP1 IFNL1

1.19e-0563955int:CRYBB3
InteractionIFNL1 interactions

CRYBB3 IFNL2 IFNL1

1.63e-0511953int:IFNL1
InteractionCREBBP interactions

HIF1A HIVEP2 RPS6KA2 HUWE1 TRRAP YY1 PIAS1 IQGAP1 HDAC3 ARID1B POU2F3 EPAS1

2.46e-055999512int:CREBBP
Cytoband19q13.13

IFNL2 IFNL3 IFNL1

4.21e-061598319q13.13
Cytoband7q31.1

THAP5 DOCK4

9.22e-04219827q31.1
Cytoband19p13.3

MIR7-3HG POLRMT PLPPR3 GRIN3B

1.71e-0323798419p13.3
Cytoband6q25.1

ARID1B ZC3H12D

3.02e-03389826q25.1
CytobandEnsembl 112 genes in cytogenetic band chr7q31

THAP5 DOCK4 FOXP2

3.42e-03140983chr7q31
GeneFamilyInterferons

IFNL2 IFNL3 IFNL1

2.54e-0432703598
CoexpressionJOHNSTONE_PARVB_TARGETS_3_UP

PEG10 HLA-E SAMHD1 GSAP HUWE1 CDCP1 WLS IQGAP1 HINT3 CTNND1 EPAS1

5.51e-074339611M2240
CoexpressionLAKE_ADULT_KIDNEY_C22_ENDOTHELIAL_CELLS_GLOMERULAR_CAPILLARIES

DOCK4 CACNA1C HLA-E PIAS1 HIVEP3 EPAS1

1.15e-05137966M39241
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DOCK4 CACNA1C MYO10 PRR16 HMCN1 LRFN5 LTBP2

3.03e-07200987e8462395fee0a532d1e7ec7f1795f28c42af6541
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-EECs|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VWA5B2 MIR7-3HG RNF183 DNAH12 KCNJ11 GRIN3B

1.77e-061659864b4e75ad0eb0a6b00c30a000ec6267e23ba2e496
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-SPN_Neuron_STR|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FOXP2 RYR1 TRANK1 THPO GRIN3B DNASE1L2

1.77e-061659861b7dfa173e83aa8c46a3153a3261866c065c3b73
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-medium_spiny_neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FOXP2 RYR1 TRANK1 THPO GRIN3B DNASE1L2

1.77e-06165986b4f7d33af7d053ec07b01bd67d861600a9c4822e
ToppCellControl-Fibroblasts-Alveolar_FB|Control / group, cell type (main and fine annotations)

DOCK4 CACNA1C SAMHD1 PRR16 HMCN1 LTBP2

3.65e-0618798692d468dde81125d51daf7abd4703741abe1ab91c
ToppCellAdult-Mesenchymal-matrix_fibroblast_1_cell-D175|Adult / Lineage, Cell type, age group and donor

CACNA1C MYO10 PRR16 HMCN1 LRFN5 LTBP2

3.65e-06187986e15d2967aac248da3517bc2c7d1beaa1d5a0aa7f
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CACNA1C HIF1A MYO10 CAMK2D HIVEP3 LRFN5

4.12e-0619198608720998aa55131d7377c4c67c4c935865bd7d79
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AQP11 RPS6KA2 PDX1 WLS SCNN1B PC

4.12e-06191986f76f3f5c7902a3659d8cbe470f96ce57c8a6744d
ToppCellCOPD-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

DOCK4 MYO10 HIVEP3 PRR16 HMCN1 LTBP2

4.24e-0619298662904f94dfce430456f05066522cbf9bd29f4d7e
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

DOCK4 CACNA1C MYO10 HIVEP3 PRR16 HMCN1

4.37e-0619398699525545552b371c86b18b6ea6f4897dc6e9a9ec
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

DOCK4 CACNA1C MYO10 HIVEP3 PRR16 HMCN1

4.37e-06193986b3ad5ff480d99217f36cc7471e5a96a519ddb409
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DOCK4 CACNA1C MYO10 PRR16 HMCN1 LRFN5

4.50e-06194986011e14d9ed1393275f892060e7708ffadcd0767f
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO10 RPS6KA2 HUWE1 IQGAP1 FNIP1 PC

4.64e-061959867796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell367C-Fibroblasts-Fibroblast-C_(Myofibroblast)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

DOCK4 MYO10 TMEM176A HIVEP3 HMCN1 LTBP2

4.78e-061969866730743cf088c419ccc2d28765769fc09d3ba6a7
ToppCell367C-Fibroblasts-Fibroblast-C_(Myofibroblast)|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

DOCK4 MYO10 TMEM176A HIVEP3 HMCN1 LTBP2

4.78e-0619698621dab89f3699037138a9c7a0e4dc98739a9fad9c
ToppCellSepsis-ICU-SEP-Myeloid-cDC1|ICU-SEP / Disease, condition lineage and cell class

FNIP2 CAMK2D RPS6KA2 CDCP1 ANKRD55 HPS5

4.92e-06197986e3174e90ea6136f1aa3a4a185b86458e35d51fd4
ToppCellTransverse-(5)_Dendritic_cell-(53)_Lymphoid_DC|Transverse / shred on region, Cell_type, and subtype

TMEM176A SOCS6 CDCP1 BCR RYR1 PC

4.92e-0619798615b87fd3906d7388c271d30d0c64b1bcc490801c
ToppCellTransverse-Dendritic_cell-Lymphoid_DC|Transverse / Region, Cell class and subclass

TMEM176A SOCS6 CDCP1 BCR RYR1 PC

4.92e-06197986a58af0ea82f76f2a7abac1f62629ff20d552fc63
ToppCellcritical|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

FNIP2 DOCK4 HIF1A HLA-E GSAP FNIP1

5.21e-0619998616c55cb8a0e740342009965f0eddfb0ed2858fab
ToppCellLPS_only-Endothelial-Endothelial-Activated_Alv_Cap|LPS_only / Treatment groups by lineage, cell group, cell type

HIF1A HIVEP2 SAMHD1 BCR CTNND1 EPAS1

5.36e-06200986edb64556b3fefe3144f73b6efe23b9ffd34091d2
ToppCellTracheal-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1C SAMHD1 PRR16 HMCN1 LRFN5 LTBP2

5.36e-06200986b4ccffdd79526c85e5273d27b668dbddcddba1ee
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1C SAMHD1 PRR16 HMCN1 LRFN5 LTBP2

5.36e-062009863dd022e974fec7013ba18f333da63f58fbf2dd7c
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1C SAMHD1 PRR16 HMCN1 LRFN5 LTBP2

5.36e-0620098634f52003988ce6329d8deeee1ab875fa77e01e9d
ToppCellICU-SEP-Myeloid-cDC1|ICU-SEP / Disease, Lineage and Cell Type

FNIP2 CAMK2D RPS6KA2 CDCP1 ANKRD55

2.86e-051619859fb73909fc2ec99f96ca2eed1a053bce89de7d16
ToppCellfacs-Lung-ENDOMUCIN-18m-Myeloid-myeloid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RNF183 GSAP DGLUCY DEF6 ZC3H12D

3.13e-0516498554f8f11d2fa899005530c08e7a1ee728c7b0799c
ToppCelldroplet-Heart-nan-24m-Mesenchymal-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO10 DIS3 CRYBB3 NRK HPS5

3.41e-05167985a35ace2c722936d2a3e1f0826e5b6ec6b1340d2b
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-I_cells_(CCK+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VWA5B2 MIR7-3HG PDX1 CDCP1 DNAH12

3.93e-051729852651dece87c3e3d2d6370f5274ebae357474b825
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-K_cells_(GIP+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VWA5B2 MIR7-3HG PDX1 CDCP1 DNAH12

4.15e-051749853503c7dec498597f76a86dbd5e4bb2311e743bde
ToppCell5'-Adult-LargeIntestine-Epithelial-neuro-epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VWA5B2 MIR7-3HG PEG10 LY6G6D DNASE1L2

4.15e-051749859f114e61458659005b6d0b4aa30a7a059e7aa5c6
ToppCell5'-Adult-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VWA5B2 MIR7-3HG PEG10 RNF183 DNASE1L2

4.26e-05175985182e45f5c02214d6b9f317ff5dc43af8b42de978
ToppCellfacs-Large_Intestine-Distal-18m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPPK1 HIVEP2 RPS6KA2 LY6G6D POU2F3

4.26e-05175985f24b664b9056b5976bf2222e8013f15c09e049ad
ToppCelldroplet-Lung-3m-Mesenchymal-myofibroblast-pericyte_cell-pericyte|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ARHGEF17 BCR MEOX1 LTBP2 EPAS1

4.38e-05176985e2b59a904c5c8f9c88e1e63788e9b6485f22edd0
ToppCelldroplet-Lung-3m-Mesenchymal-myofibroblast-pericyte_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ARHGEF17 BCR MEOX1 LTBP2 EPAS1

4.38e-05176985f931192e3cc65414e2245354f443473696cc7ce8
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-D_cells_(SST+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VWA5B2 MIR7-3HG PDX1 DNAH12 KCNJ11

4.50e-051779858dbef0005095c01a806d8c7f723dc48a4650efec
ToppCellChildren_(3_yrs)-Mesenchymal-pericyte_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

CACNA1C MYO10 ARHGEF17 PRR16 LTBP2

4.62e-05178985185b44700f06ec58b3c09c80520502166c965fd6
ToppCellfacs-Large_Intestine-Proximal-18m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPPK1 RPS6KA2 LY6G6D KCNJ11 POU2F3

4.62e-0517898509a215a0d6e98e4bb920cabda12af08ff4de3c98
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Endothelial|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO10 BCR CRYBB3 KCNJ11 EPAS1

4.87e-05180985f9b7d5eb7b6ea72253c89bdc351ad2b4a53f7d8e
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Endothelial-endothelial_cell|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO10 BCR CRYBB3 KCNJ11 EPAS1

4.87e-0518098553db6032eda0e590ae7e01c9c3b472785ea6782f
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Endothelial-nan|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO10 BCR CRYBB3 KCNJ11 EPAS1

4.87e-0518098528bc10b9d0e4430b952260014d8a6ff337860ac6
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-I_cells_(INS+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VWA5B2 MIR7-3HG PDX1 RNF183 DNAH12

4.87e-051809850c5d9245b8a7cc34ad52522d31559906cda55bdf
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

CACNA1C MYO10 PRR16 HMCN1 LRFN5

5.00e-051819859ede19228ba5c0668a9c06c915510b95585216ef
ToppCellMesenchymal_cells-Adipo-CAR|Mesenchymal_cells / Lineage and Cell class

TMEM176A SAMHD1 PRR16 LTBP2 EPAS1

5.00e-051819851cfb03eb03a37b036b4eeacec69c9b8163af1ee4
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VWA5B2 MIR7-3HG RNF183 LY6G6D KCNJ11

5.13e-051829850e589bf97d51b4b2f723f8c45853ad81b7ce8778
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANK1 APOB TRANK1 HMCN1 NRK

5.41e-051849852cbed6462fea2622871bb7e49b0df3d984239281
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4|TCGA-Pancreas / Sample_Type by Project: Shred V9

DOCK4 SAMHD1 HMCN1 LRFN5 NRK

5.41e-0518498567164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANK1 APOB TRANK1 HMCN1 NRK

5.41e-05184985ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANK1 APOB TRANK1 HMCN1 NRK

5.41e-051849852b19a8c5f823e00812908b23e66bb4e563278aff
ToppCelldroplet-Heart-nan-3m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK4 MYO10 RPS6KA2 HMCN1 NRK

5.69e-051869850ae5fbe9f210cb25092394267e1d3d6ed05627b8
ToppCellControl-Fibroblasts-Other_FB|Control / group, cell type (main and fine annotations)

CACNA1C PRR16 HMCN1 LRFN5 LTBP2

5.84e-05187985bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VWA5B2 MIR7-3HG PDX1 RNF183 DNAH12

5.99e-05188985b6aad90fa77fbaf80487a55415aa6c245f2d1f7e
ToppCellfacs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWA5B2 RPS6KA2 PDX1 SCNN1B PC

5.99e-05188985a91443aa8fa8fa87f7501c59219daa0305bd0bbf
ToppCellControl-Endothelial-VE_Venous|Endothelial / Disease state, Lineage and Cell class

FNIP2 MYO10 ANKRD55 LTBP2 EPAS1

6.30e-051909854e30155203b4a8c5e496fcbe9348b67b98ebc625
ToppCellControl-Fibroblasts|Control / group, cell type (main and fine annotations)

CACNA1C PRR16 HMCN1 LRFN5 LTBP2

6.30e-051909853a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCellfacs-Pancreas|facs / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWA5B2 RPS6KA2 PDX1 ARHGEF17 KCNJ11

6.45e-05191985d48e5f67d384226add7d7fb2a124954136e09a82
ToppCellRA-09._Endothelium_I|World / Chamber and Cluster_Paper

DOCK4 MYO10 HLA-E MEOX1 EPAS1

6.45e-05191985c8a0c2af119bc34a8f694a7d30642f28002c84b9
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CACNA1C PRR16 HMCN1 LRFN5 LTBP2

6.45e-051919856688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPS6KA2 PDX1 WLS SCNN1B PC

6.61e-051929855b7093d5af5ae7b0e6d3a464cc56272440ecedad
ToppCellRA-09._Endothelium_I|RA / Chamber and Cluster_Paper

DOCK4 MYO10 HLA-E MEOX1 EPAS1

6.61e-051929858a1b1c3e83a68ad74f8f4eb00455c9e41aa57cfc
ToppCellRV-10._Endothelium_II|RV / Chamber and Cluster_Paper

DOCK4 HLA-E BCR HMCN1 EPAS1

6.78e-0519398501c2df9206f1527c578e808978e58196c35e72f5
ToppCellControl-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

DOCK4 CACNA1C MYO10 PRR16 HMCN1

6.78e-051939855896242f713ae5fd1a4ebb63827f15d7279dced2
ToppCellMesenchymal-matrix_fibroblast_1_cell|World / Lineage, Cell type, age group and donor

CACNA1C MYO10 PRR16 HMCN1 LRFN5

6.78e-05193985acad568621ed677031797b8c2e34dafea798d681
ToppCellCOVID-19-kidney-FLT1+PLVAP+EC|kidney / Disease (COVID-19 only), tissue and cell type

DOCK4 CACNA1C USP13 HLA-E EPAS1

6.78e-05193985479abb1cd2eb978b8a4fdb900069a6329fc8cade
ToppCellControl-Fibroblasts-Intermediate_pathological_FB|Control / group, cell type (main and fine annotations)

CACNA1C PRR16 HMCN1 LRFN5 LTBP2

6.95e-0519498503a269f75a481ea54aea8e6444605db8d6df493d
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CACNA1C MYO10 PRR16 HMCN1 LRFN5

6.95e-0519498535f132cc38ac133be01834ed0946188aa0757eb4
ToppCellCTRL-Myeloid-Monocyte_Macrophage|CTRL / Disease state, Lineage and Cell class

FNIP2 DOCK4 HIF1A TMEM176A PRR16

6.95e-05194985927480f56cccd3940b689f3c40ee132fe3e63745
ToppCellfacs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPS6KA2 PDX1 ARHGEF17 SCNN1B PC

7.12e-05195985bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCellMild/Remission-B_naive-8|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

CAMK2D PEG10 IQGAP1 HIVEP3 ARID1B

7.12e-051959850a3221e4d1fa31a35868bdda0f0cc873c233b407
ToppCellCOVID-19-Fibroblasts-Alveolar_FB|COVID-19 / group, cell type (main and fine annotations)

CACNA1C MYO10 PRR16 HMCN1 LTBP2

7.12e-05195985603050beeb33c331d4b2e3fa46cae3f3e0e4bdc7
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FNIP2 USP13 PEG10 RPS6KA2 FASN

7.12e-05195985d9694db6bf239636d1335016878c98f6ee2eb0eb
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPS6KA2 HUWE1 IQGAP1 FNIP1 PC

7.12e-051959853e519cffa6144a62b06124642a14c9ff39b76554
ToppCellCOPD-Stromal-Myofibroblast|COPD / Disease state, Lineage and Cell class

CACNA1C PRR16 HMCN1 LRFN5 LTBP2

7.29e-05196985af206bb5bbb8b604a6212acd79878bcc3d326cec
ToppCellnucseq-Mesenchymal-Fibroblastic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CACNA1C PRR16 HMCN1 LRFN5 LTBP2

7.29e-051969857d8505dac15fa59935ccf592afc54b04c4c6554f
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.4.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FNIP2 USP13 PEG10 RPS6KA2 FASN

7.29e-05196985006d783a530aa6e1e6545dcc2e6b00bb300fe070
ToppCellCOPD-Stromal-Myofibroblast|World / Disease state, Lineage and Cell class

CACNA1C PRR16 HMCN1 LRFN5 LTBP2

7.47e-05197985d51f484b4e01ac64233950d0b97fa88825ea1dbb
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

VWA5B2 PLPPR3 DNAH12 GRIN3B CPLANE1

7.47e-0519798574a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCellLV-09._Endothelium_I|LV / Chamber and Cluster_Paper

DOCK4 HLA-E MEOX1 HMCN1 EPAS1

7.47e-05197985f9731d4d636e51b94a96805eee6afe9aedc175e3
ToppCellCOVID-19-lung-Fibroblast|COVID-19 / Disease (COVID-19 only), tissue and cell type

CACNA1C PRR16 HMCN1 LRFN5 LTBP2

7.65e-051989853ec01a55ade5e1627258cc3cfebb2c3207a4cb43
ToppCellParenchymal-10x5prime-Stromal-Fibroblastic-Fibro_peribronchial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1C TMEM176A PRR16 HMCN1 LTBP2

7.65e-05198985300d7cc56207d77168390fa1ffcbcf76767b1b80
ToppCellAdult-Mesenchymal|Adult / Lineage, Cell type, age group and donor

CACNA1C PRR16 HMCN1 LRFN5 LTBP2

7.65e-0519898526e55b409db2a1637c95fae7c54b0abea1ef550c
ToppCellCOVID-19-lung-Fibroblast|lung / Disease (COVID-19 only), tissue and cell type

CACNA1C PRR16 HMCN1 LRFN5 LTBP2

7.65e-05198985df3de77216f5c5d6141ec44d01c56b942f611838
ToppCellnucseq-Mesenchymal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CACNA1C PRR16 HMCN1 LRFN5 LTBP2

7.65e-051989858f52243ca8b9ba68a75ae411506a3a6de258eb97
ToppCell5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FNIP2 USP13 PEG10 RPS6KA2 FASN

7.83e-051999852dc33804f6691d7c9682e6c9b885e945fb97fc36
ToppCellNS-critical|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DOCK4 HIF1A HLA-E GSAP FNIP1

7.83e-05199985f7c14dc9a9e659f89352dccf8954d6cbada011ab
ToppCellHematolymphoid-Microglia-TYROBP----L1-3|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

DOCK4 FOXP2 SOCS6 RYR1 HIVEP3

8.02e-05200985a20dce14f94777687aad57d6fbe3258ad376f63f
ToppCellLPS_IL1RA-Endothelial-Endothelial-Activated_Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

HIF1A HIVEP2 RPS6KA2 CTNND1 EPAS1

8.02e-052009852d07237022b409c4fac6fcf99b68c8affb3007cd
ToppCellBronchial-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1C PRR16 HMCN1 LRFN5 LTBP2

8.02e-05200985389cc775c8419d90fb77cd794376d2160a7bf44e
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1C SAMHD1 PRR16 LRFN5 LTBP2

8.02e-05200985a4ec0e80f5422b91b85264a9bb74568dd577e285
ToppCellHematolymphoid-Microglia-TYROBP--|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

DOCK4 FOXP2 SOCS6 RYR1 HIVEP3

8.02e-05200985dc344b3ec51d506952e38f0b3a7795d65f9dd4eb
ToppCellHematolymphoid-Microglia-TYROBP-|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

DOCK4 FOXP2 SOCS6 RYR1 HIVEP3

8.02e-052009853bba5219453322198e8fdb0921d5f8c403598751
ToppCellHematolymphoid-Microglia|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

DOCK4 FOXP2 SOCS6 RYR1 HIVEP3

8.02e-0520098521bcca3b670fe9bac034aef2275d3de4a9a73e2b
ToppCellParenchymal-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1C PRR16 HMCN1 LRFN5 LTBP2

8.02e-05200985cf433f9b43d7db07acaf70e060f8f77c974e72f3
ToppCellBronchial-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1C PRR16 HMCN1 LRFN5 LTBP2

8.02e-05200985cae972324d1dfea6efeaf6013f265c7c6bb48db4
ToppCellTracheal-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1C SAMHD1 PRR16 LRFN5 LTBP2

8.02e-05200985c318d14bd6fd6f42c597eb55ac9e2f48008aeb9b
ToppCell3'-Adult-LargeIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DOCK4 HLA-E MEOX1 HMCN1 EPAS1

8.02e-05200985cee07d9370656e1c428a7a9e9fbd175129901374
ToppCellBronchial-10x5prime-Stromal-Fibroblastic-Fibro_alveolar|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1C TMEM176A PRR16 HMCN1 LTBP2

8.02e-05200985cb31cfcfa8e6d6cc610c4c22e97bc009dd8a9e7c
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1C PRR16 HMCN1 LRFN5 LTBP2

8.02e-05200985311fab076f2ceb258e3970eb21e39344b894042a
ToppCellHematolymphoid-Microglia-TYROBP---|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

DOCK4 FOXP2 SOCS6 RYR1 HIVEP3

8.02e-05200985a8646d0fca99f10827c2d2a12e584660ef7155f1
ToppCellHematolymphoid-Microglia-TYROBP|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

DOCK4 FOXP2 SOCS6 RYR1 HIVEP3

8.02e-0520098533036d21c1c82109284473a515c4f890b33fdd5c
ToppCelldistal-2-mesenchymal-Pericyte|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MYO10 WLS ARHGEF17 PRR16 LTBP2

8.02e-052009854ee0b2f56c2652435fa78bf6b3c90cea28df74e0
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1C PRR16 HMCN1 LRFN5 LTBP2

8.02e-0520098558b38f9a484ee94191091a0659ed62ebed2d4a14
Diseasecervical carcinoma

CAMK2D HLA-E GSAP ALMS1 LRFN5 EXOC1

2.63e-05182946EFO_0001061
Diseaseosteonecrosis

HIVEP3 OR10H2 LRFN5

6.84e-0525943EFO_0004259
DiseaseManic Disorder

CACNA1C RPS6KA2 TRANK1 PC

7.97e-0571944C0024713
Diseasehepatitis C (is_implicated_in)

SAMHD1 IFNL3 IFNL1

9.68e-0528943DOID:1883 (is_implicated_in)
DiseasePermanent neonatal diabetes mellitus

PDX1 KCNJ11

9.98e-055942cv:C1833104
DiseaseManic

CACNA1C RPS6KA2 TRANK1 PC

1.15e-0478944C0338831
DiseaseDepression, Bipolar

CACNA1C RPS6KA2 TRANK1 PC

1.21e-0479944C0005587
Diseasepulmonary hypertension (biomarker_via_orthology)

HIF1A RYR1 CTNND1 EPAS1

1.27e-0480944DOID:6432 (biomarker_via_orthology)
Diseasebody weight

CACNA1C HIVEP2 FOXP2 ETV6 HUWE1 PRR16 FASN DNAH12 LRFN5 FNIP1 LTBP2 CPSF2 EPAS1

1.80e-0412619413EFO_0004338
DiseaseBurkitt Lymphoma

ETV6 BCR PC

2.07e-0436943C0006413
DiseaseNeonatal diabetes mellitus

PDX1 KCNJ11

2.09e-047942cv:C0158981
DiseaseDIABETES MELLITUS, PERMANENT NEONATAL

PDX1 KCNJ11

2.09e-047942C1833104
DiseaseAdenocarcinoma of large intestine

RPS6KA2 TRRAP NRK PKN1

2.56e-0496944C1319315
Diseasetelomere length

SAMHD1 HIVEP3 LRFN5 CPLANE1 IFNL2 IFNL1

5.06e-04313946EFO_0004505
Diseasebronchopulmonary dysplasia (biomarker_via_orthology)

HIF1A EPAS1

6.49e-0412942DOID:11650 (biomarker_via_orthology)
Diseasejuvenile polyposis syndrome (implicated_via_orthology)

HIVEP2 HIVEP3

7.65e-0413942DOID:0050787 (implicated_via_orthology)
Diseaseleukemia (is_implicated_in)

ETV6 BCR

7.65e-0413942DOID:1240 (is_implicated_in)
Diseasesexual dimorphism measurement

EPPK1 HIVEP2 TMEM176A ETV6 APOB SAMHD1 TRANK1 DEF6 FNIP1 LTBP2 PC

7.86e-0411069411EFO_0021796
DiseaseBipolar Disorder

CACNA1C HIF1A RPS6KA2 HLA-E BCR TRANK1 PC

8.43e-04477947C0005586
DiseaseMaturity onset diabetes mellitus in young

PDX1 KCNJ11

8.91e-0414942C0342276
DiseaseP wave duration

CAMK2D EPAS1

1.03e-0315942EFO_0005094
Diseaselung non-small cell carcinoma (is_implicated_in)

HIF1A HDAC3 ARID1B EPAS1

1.04e-03139944DOID:3908 (is_implicated_in)
Diseasediabetic retinopathy (implicated_via_orthology)

HIF1A PDX1

1.17e-0316942DOID:8947 (implicated_via_orthology)
DiseaseMonogenic diabetes

PDX1 KCNJ11

1.17e-0316942C3888631
Diseasetype 2 diabetes mellitus (biomarker_via_orthology)

HIF1A PDX1 KCNJ11 EPAS1

1.27e-03147944DOID:9352 (biomarker_via_orthology)
Diseaseischemia (implicated_via_orthology)

ARID1B SCNN1B

1.32e-0317942DOID:326 (implicated_via_orthology)
DiseaseDrugs used in diabetes use measurement

HIVEP2 ANK1 RPAP1 KCNJ11 LTBP2

1.36e-03255945EFO_0009924
Diseasecerebral infarction (is_marker_for)

HIF1A APOB

1.66e-0319942DOID:3526 (is_marker_for)
Diseasepolycystic kidney disease (biomarker_via_orthology)

HIF1A EPAS1

1.66e-0319942DOID:0080322 (biomarker_via_orthology)
DiseasePrecursor B-cell lymphoblastic leukemia

ETV6 BCR

2.03e-0321942C1292769
DiseaseInfiltrating duct carcinoma of female breast

NRK PKN1

2.03e-0321942C3165106
Diseasehyperglycemia (biomarker_via_orthology)

PDX1 EPAS1

2.03e-0321942DOID:4195 (biomarker_via_orthology)
Diseasetype 2 diabetes mellitus (is_implicated_in)

HIF1A PDX1 APOB KCNJ11

2.21e-03171944DOID:9352 (is_implicated_in)
Diseasebipolar disorder

CACNA1C HIVEP2 RPS6KA2 HUWE1 TRANK1 PC EPAS1

2.49e-03577947MONDO_0004985
DiseaseNeonatal diabetes mellitus

PDX1 KCNJ11

2.87e-0325942C0158981
Diseaseeye color

ETV6 HIVEP3 TRANK1

3.01e-0390943EFO_0003949

Protein segments in the cluster

PeptideGeneStartEntry
ELAHELPLPHSVSSH

EPAS1

36

Q99814
HVHQIDAVLLSHPDP

CPSF2

51

Q9P2I0
VLHDLLKHTPASHPD

BCR

656

P11274
QVPSDILHLPVELHD

CDCP1

431

Q9H5V8
TPLHVAVHHNNLDIV

ANK1

571

P16157
QVLPHSHLPEEALEV

ALMS1

1441

Q8TCU4
IELVLPPHANHHGNT

ACOT12

186

Q8WYK0
VHHHPLLPRHELNMA

ARID1B

71

Q8NFD5
HQEVSVPPHLRHLHN

ANKRD55

526

Q3KP44
HDILHAIINFDSPPH

DMXL1

2206

Q9Y485
HTLLLDHQDAIAPEH

IQGAP1

1306

P46940
PHSLPQEEHIFTEQH

MEOX1

71

P50221
KLPHLLNSTNHIHEP

LRFN5

376

Q96NI6
HTPEDHPDHPLLLEA

ARHGEF17

1226

Q96PE2
PPPHLVSSHHELAVL

MFRP

381

Q9BY79
VDNVHHNPPTIELLH

ETV6

166

P41212
HSLHLHPELPTTDPA

MIR7-3HG

86

Q8N6C7
SHEIQHFLCHVPPLL

OR10H2

171

O60403
LHLEPPKTHVTHHPI

HLA-E

201

P13747
IQHPETPLHISGFHL

NOB1

116

Q9ULX3
HHTVPKPVHILLSNI

OR52W1

271

Q6IF63
AHQLPLPHNVSSHLD

HIF1A

41

Q16665
ISHLHLHVLAPVDQL

HINT3

141

Q9NQE9
PSDIIQLCHHHPAEF

HPS5

876

Q9UPZ3
APSDLHHHQDLEIIV

KCNJ11

271

Q14654
DPAVAHLHHHLPAQL

PDX1

76

P52945
ALINHPELPITQHTH

OR51S1

266

Q8NGJ8
HIQLVDAHEAPPTLI

SLC10A3

146

P09131
QHLEHIDPTASHIPR

FAM214A

491

Q32MH5
PHIHSIHVKEEPVIA

FOXP2

666

O15409
HQVVTHLLALHADIP

NOL6

616

Q9H6R4
TPVNLDTELPEHVLH

DNAH12

376

Q6ZR08
IHGHHPAPEENLQVL

MYO10

1816

Q9HD67
ALVLPHIASHHQVDP

PEG10

256

Q86TG7
SLEHEPETHTLHLQP

PRDM10

471

Q9NQV6
PETHTLHLQPQHEES

PRDM10

476

Q9NQV6
TNHPPGHVLAALEHL

HAUS5

236

O94927
LKAPLDREEQPHHHL

PCDHGB3

196

Q9Y5G1
TVHIHPQAAPVVCRH

HUWE1

3321

Q7Z6Z7
EPHLEASQHLPVPKH

POU2F3

161

Q9UKI9
HAPSVQIHDVPADLL

HDAC3

371

O15379
PAHAANSVHPVHPIL

OLIG3

171

Q7RTU3
AHRHVTLHVHEPPVI

HMCN1

3976

Q96RW7
APAPDLVVADIHSLH

PRR35

111

P0CG20
PHIESHPLPENHLLL

GSAP

156

A4D1B5
LHIPEFQLPHISHTI

APOB

2736

P04114
EHHHSLLLPAEVPVQ

C2CD3

1076

Q4AC94
TVLPLHLVHHQALAV

CACNA1C

2001

Q13936
LIPLHAAPHQAVAEI

DNASE1L2

166

Q92874
LPVVLHHLHIHLQEQ

DOCK4

831

Q8N1I0
HHVNVLPPLHIKTEQ

CPLANE1

961

Q9H799
SLLEHLSHVHEPNPL

EIF2AK1

71

Q9BQI3
LSHAVQHPVLDEPIA

FNIP1

1031

Q8TF40
ADLVHTVHHPVLDEP

FNIP2

976

Q9P278
PLNIDSPHHKLHLFE

CRYBB3

106

P26998
EDVLDQPLHTLHHIL

IFNL1

111

Q8IU54
DVLDQPLHTLHHILS

IFNL2

121

Q8IZJ0
GDVLDQPLHTLHHIL

IFNL3

116

Q8IZI9
HNLYTVLHIPHDPVA

DEF6

36

Q9H4E7
VLHIPHDPVALEEHF

DEF6

41

Q9H4E7
PSLVKVHIHHPPEAS

LTBP2

471

Q14767
HHHSVPVFIPLEEIA

CENPO

151

Q9BU64
LAQHSVELTLPNHHP

EXOC1

366

Q9NV70
IPEVHHISQDPLHYS

DGLUCY

271

Q7Z3D6
HVPEHAVVLEIAPHA

FASN

751

P49327
NHTPLVLIDERNPHH

SCNN1B

146

P51168
LTNLSEHVPHDPRLH

RYR1

4146

P21817
EHVPHDPRLHNFLEL

RYR1

4151

P21817
TDQLPLAHHLLVVHH

POLRMT

236

O00411
DHALHALTDEVIIPH

CTNND1

491

O60716
SNKPIHTIILNPHVH

CAMK2D

406

Q13557
PVTLIHQHPACVAAH

LY6G6D

61

O95868
LLSQDHHVLLPLHLD

NRK

591

Q7Z2Y5
ELSGIHDPKLHHPAQ

GRIN3B

676

O60391
LEPHHVILEGHQLCL

RNF183

86

Q96D59
PEAPQHTHIDVHIHQ

TMEM176A

11

Q96HP8
KVINDPIHGHIELHP

SAMHD1

116

Q9Y3Z3
IKNREVHLHSEPVHP

PRR16

226

Q569H4
VIDPQHHHRLPLETA

EPPK1

2016

P58107
PEEHQIAHLPLSEVP

PTTG3P

131

Q9NZH4
LQELHAHVVLPDPAA

PKN1

91

Q16512
PKHELELPHLTSALH

PIAS1

116

O75925
ELPHLTSALHPVHPD

PIAS1

121

O75925
KVLLGILPPHHESHA

TBC1D7

61

Q9P0N9
EVLLLEHDVPHQPFS

DIS3

431

Q9Y2L1
THELQLLSEQHPAHP

AQP11

61

Q8NBQ7
HLHLPELHIFQPEEK

ZNF578

161

Q96N58
VTIDAHAPHHPVVHL

PLPPR3

581

Q6T4P5
VNTDVPHQHPELLHS

THAP5

131

Q7Z6K1
PHQHPELLHSSSLVK

THAP5

136

Q7Z6K1
LQPLVTDDPTQVHHH

YY1

86

P25490
LQVFHHPVAQTPLHE

HIVEP3

1121

Q5T1R4
LAPDVDLPTHLGLHH

RPAP1

366

Q9BWH6
HPERPHHAQLAVADE

ZC3H12D

276

A2A288
LEILLHPSEPHQPHL

VWA5B2

266

Q8N398
EANDIVFSVHIPLPH

WLS

86

Q5T9L3
APEHPHQLEHLHQIF

TRANK1

1136

O15050
KHLPEQPHLFPHQET

HIVEP2

1181

P31629
DRFPDLPLHIHTHDT

PC

761

P11498
DLVHHVRQHLPLSDL

TRRAP

381

Q9Y4A5
LHLHLDEHVPVVIGL

SOCS6

201

O14544
EEPVLDPHLAKHLAH

USP13

276

Q92995
HVLHSRLSQCPEVHP

THPO

41

P40225
DLHKVPVHPIVQQLH

RPS6KA2

391

Q15349