Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cAMP-dependent protein kinase activity	PRKACA PRKACB PRKY	1.82e-05	7	163	3	GO:0004691
GeneOntologyMolecularFunction	cyclic nucleotide-dependent protein kinase activity	PRKACA PRKACB PRKY	4.33e-05	9	163	3	GO:0004690
GeneOntologyBiologicalProcess	positive regulation of dendrite morphogenesis	ACHE DBN1 CUL7 TIAM1 FBXO31 MFN2	1.29e-05	67	159	6	GO:0050775
GeneOntologyBiologicalProcess	positive regulation of cell morphogenesis	ACHE DBN1 CUL7 TIAM1 FBXO31 MFN2	1.53e-05	69	159	6	GO:0010770
GeneOntologyCellularComponent	asymmetric synapse	ANK2 GRID1 MGLL LRRC4B DBN1 CSMD2 SHANK3 GRK2 GRK3 CELSR3 TIAM1 ARFGAP1 MACF1 GRIN3A GRIN3B	5.20e-06	477	163	15	GO:0032279
GeneOntologyCellularComponent	postsynaptic specialization	RAPSN ANK2 GRID1 LRRC4B DBN1 CSMD2 SHANK3 GRK2 GRK3 CELSR3 TIAM1 ARFGAP1 MACF1 GRIN3A GRIN3B	9.80e-06	503	163	15	GO:0099572
GeneOntologyCellularComponent	postsynaptic density	ANK2 GRID1 LRRC4B DBN1 CSMD2 SHANK3 GRK2 GRK3 CELSR3 TIAM1 ARFGAP1 MACF1 GRIN3A GRIN3B	1.26e-05	451	163	14	GO:0014069
GeneOntologyCellularComponent	neuron to neuron synapse	ANK2 GRID1 MGLL LRRC4B DBN1 CSMD2 SHANK3 GRK2 GRK3 CELSR3 TIAM1 ARFGAP1 MACF1 GRIN3A GRIN3B	1.55e-05	523	163	15	GO:0098984
GeneOntologyCellularComponent	postsynaptic membrane	RAPSN ANK2 ACHE GRID1 LRRC4B DBN1 CSMD2 SHANK3 CELSR3 TIAM1 GRIN3A GRIN3B	8.32e-05	405	163	12	GO:0045211
GeneOntologyCellularComponent	postsynapse	RPL35A RAPSN ANK2 MYO5A ACHE GRID1 LRRC4B DBN1 CSMD2 SHANK3 GRK2 GRK3 CELSR3 TIAM1 ARFGAP1 PRKACA MACF1 GRIN3A GRIN3B HCRT	1.34e-04	1018	163	20	GO:0098794
GeneOntologyCellularComponent	postsynaptic specialization membrane	RAPSN GRID1 LRRC4B CSMD2 CELSR3 TIAM1 GRIN3A GRIN3B	1.85e-04	201	163	8	GO:0099634
GeneOntologyCellularComponent	postsynaptic density membrane	GRID1 LRRC4B CSMD2 CELSR3 TIAM1 GRIN3A GRIN3B	2.36e-04	157	163	7	GO:0098839
GeneOntologyCellularComponent	synaptic membrane	RAPSN ANK2 ACHE GRID1 LRRC4B DBN1 CSMD2 SHANK3 CELSR3 TIAM1 SYNJ1 GRIN3A GRIN3B	6.72e-04	583	163	13	GO:0097060
GeneOntologyCellularComponent	guanyl-nucleotide exchange factor complex	LAMTOR4 RASGRP3 RIC1	8.35e-04	24	163	3	GO:0032045
Domain	TMEM191C	TMEM191C TMEM191B	7.39e-05	2	161	2	PF15194
Domain	TMEM191B/C	TMEM191C TMEM191B	7.39e-05	2	161	2	IPR028186
Domain	Laminin_G_1	HSPG2 LAMA1 EGFLAM	9.86e-05	11	161	3	PF00054
Domain	-	HSPG2 LGALS16 LAMA1 ADGRV1 CELSR3 EGFLAM	1.73e-04	95	161	6	2.60.120.200
Domain	FAO_M	PDPR SARDH	2.20e-04	3	161	2	PF16350
Domain	FAO_M	PDPR SARDH	2.20e-04	3	161	2	IPR032503
Domain	EGF_Lam	HSPG2 LAMA1 CELSR3 MEGF11	2.26e-04	35	161	4	SM00180
Domain	Laminin_EGF	HSPG2 LAMA1 CELSR3 MEGF11	2.26e-04	35	161	4	PF00053
Domain	LAM_G_DOMAIN	HSPG2 LAMA1 CELSR3 EGFLAM	3.12e-04	38	161	4	PS50025
Domain	Laminin_EGF	HSPG2 LAMA1 CELSR3 MEGF11	3.12e-04	38	161	4	IPR002049
Domain	Laminin_G_2	HSPG2 LAMA1 CELSR3 EGFLAM	3.82e-04	40	161	4	PF02210
Domain	-	PDPR SARDH	4.38e-04	4	161	2	2.40.30.110
Domain	Pecanex_C	PCNX3 PCNX2	4.38e-04	4	161	2	PF05041
Domain	GcvT/YgfZ_C	PDPR SARDH	4.38e-04	4	161	2	IPR029043
Domain	Pecanex	PCNX3 PCNX2	4.38e-04	4	161	2	IPR007735
Domain	Lig_chan-Glu_bd	GRID1 GRIN3A GRIN3B	4.66e-04	18	161	3	PF10613
Domain	Glu/Gly-bd	GRID1 GRIN3A GRIN3B	4.66e-04	18	161	3	IPR019594
Domain	Lig_chan-Glu_bd	GRID1 GRIN3A GRIN3B	4.66e-04	18	161	3	SM00918
Domain	Iontro_rcpt	GRID1 GRIN3A GRIN3B	4.66e-04	18	161	3	IPR001320
Domain	Iono_rcpt_met	GRID1 GRIN3A GRIN3B	4.66e-04	18	161	3	IPR001508
Domain	Lig_chan	GRID1 GRIN3A GRIN3B	4.66e-04	18	161	3	PF00060
Domain	PBPe	GRID1 GRIN3A GRIN3B	4.66e-04	18	161	3	SM00079
Domain	LamG	HSPG2 LAMA1 CELSR3 EGFLAM	5.52e-04	44	161	4	SM00282
Domain	ConA-like_dom	HSPG2 ZAN LGALS16 LAMA1 ADGRV1 CELSR3 NBEAL2 EGFLAM	6.36e-04	219	161	8	IPR013320
Domain	PH	DOCK9 ASAP3 GRB7 ECT2 CERT1 GRK2 GRK3 TIAM1 SNTB2	7.02e-04	278	161	9	SM00233
Domain	PH_DOMAIN	DOCK9 ASAP3 GRB7 ECT2 CERT1 GRK2 GRK3 TIAM1 SNTB2	7.20e-04	279	161	9	PS50003
Domain	FYrich_C	KMT2B KMT2D	7.26e-04	5	161	2	IPR003889
Domain	FYrich_N	KMT2B KMT2D	7.26e-04	5	161	2	IPR003888
Domain	FYRC	KMT2B KMT2D	7.26e-04	5	161	2	SM00542
Domain	FYRN	KMT2B KMT2D	7.26e-04	5	161	2	SM00541
Domain	GCV_T	PDPR SARDH	7.26e-04	5	161	2	PF01571
Domain	-	PDPR SARDH	7.26e-04	5	161	2	3.30.1360.120
Domain	TrmE/GcvT_dom1	PDPR SARDH	7.26e-04	5	161	2	IPR027266
Domain	Autophagy-rel_C	VPS13C ATG2A	7.26e-04	5	161	2	IPR015412
Domain	ATG_C	VPS13C ATG2A	7.26e-04	5	161	2	PF09333
Domain	GCV_T_C	PDPR SARDH	7.26e-04	5	161	2	IPR013977
Domain	GCV_T_C	PDPR SARDH	7.26e-04	5	161	2	PF08669
Domain	GCV_T_N	PDPR SARDH	7.26e-04	5	161	2	IPR006222
Domain	FYRN	KMT2B KMT2D	7.26e-04	5	161	2	PF05964
Domain	FYRC	KMT2B KMT2D	7.26e-04	5	161	2	PF05965
Domain	FYRC	KMT2B KMT2D	7.26e-04	5	161	2	PS51543
Domain	FYRN	KMT2B KMT2D	7.26e-04	5	161	2	PS51542
Domain	PH_domain	DOCK9 ASAP3 GRB7 ECT2 CERT1 GRK2 GRK3 TIAM1 SNTB2	7.39e-04	280	161	9	IPR001849
Domain	CUB	CSMD2 ST14 CSMD1 DCBLD2	8.33e-04	49	161	4	PF00431
Domain	PH	DOCK9 ASAP3 GRB7 CERT1 GRK2 GRK3 TIAM1 SNTB2	8.51e-04	229	161	8	PF00169
Domain	CUB	CSMD2 ST14 CSMD1 DCBLD2	9.00e-04	50	161	4	SM00042
Domain	-	CSMD2 ST14 CSMD1 DCBLD2	1.04e-03	52	161	4	2.60.120.290
Domain	CUB	CSMD2 ST14 CSMD1 DCBLD2	1.12e-03	53	161	4	PS01180
Domain	AGC-kinase_C	GRK2 GRK3 PRKACA PRKACB	1.38e-03	56	161	4	IPR000961
Domain	AGC_KINASE_CTER	GRK2 GRK3 PRKACA PRKACB	1.38e-03	56	161	4	PS51285
Domain	S_TK_X	GRK2 GRK3 PRKACA PRKACB	1.38e-03	56	161	4	SM00133
Domain	CUB_dom	CSMD2 ST14 CSMD1 DCBLD2	1.47e-03	57	161	4	IPR000859
Domain	GPCR_kinase	GRK2 GRK3	1.51e-03	7	161	2	IPR000239
Domain	Laminin_G	HSPG2 LAMA1 CELSR3 EGFLAM	1.57e-03	58	161	4	IPR001791
Domain	Chorein_N	VPS13C ATG2A	2.00e-03	8	161	2	PF12624
Domain	AIG1	GIMD1 GIMAP5	2.00e-03	8	161	2	PF04548
Domain	G_AIG1	GIMD1 GIMAP5	2.00e-03	8	161	2	IPR006703
Domain	Calx_beta	ADGRV1 FREM2	2.00e-03	8	161	2	SM00237
Domain	VPS13_N	VPS13C ATG2A	2.00e-03	8	161	2	IPR026854
Domain	LAMININ_IVA	HSPG2 LAMA1	2.00e-03	8	161	2	PS51115
Domain	Laminin_B	HSPG2 LAMA1	2.00e-03	8	161	2	PF00052
Domain	LamB	HSPG2 LAMA1	2.00e-03	8	161	2	SM00281
Domain	Laminin_IV	HSPG2 LAMA1	2.00e-03	8	161	2	IPR000034
Domain	G_AIG1	GIMD1 GIMAP5	2.00e-03	8	161	2	PS51720
Domain	EGF_LAM_2	HSPG2 LAMA1 CELSR3	2.15e-03	30	161	3	PS50027
Domain	EGF_LAM_1	HSPG2 LAMA1 CELSR3	2.15e-03	30	161	3	PS01248
Domain	Calx_beta	ADGRV1 FREM2	2.55e-03	9	161	2	IPR003644
Domain	Calx-beta	ADGRV1 FREM2	2.55e-03	9	161	2	PF03160
Pathway	REACTOME_CA_DEPENDENT_EVENTS	ADCY9 GRK2 PRKACA PRKACB	5.29e-05	26	114	4	MM14495
Pathway	KEGG_MEDICUS_REFERENCE_AVP_V2R_PKA_SIGNALING_PATHWAY	ADCY9 PRKACA PRKACB	5.93e-05	10	114	3	M47648
Pathway	REACTOME_SIGNALING_BY_HEDGEHOG	DYNC2H1 PSMD2 PSMD5 ADCY9 GRK2 PRKACA PRKACB	1.22e-04	137	114	7	MM15182
Pathway	REACTOME_HEDGEHOG_OFF_STATE	DYNC2H1 PSMD2 PSMD5 ADCY9 PRKACA PRKACB	2.06e-04	105	114	6	MM15206
Pathway	REACTOME_SIGNALING_BY_HEDGEHOG	DYNC2H1 PSMD2 PSMD5 ADCY9 GRK2 PRKACA PRKACB	2.14e-04	150	114	7	M27440
Pathway	REACTOME_CA_DEPENDENT_EVENTS	ADCY9 GRK2 PRKACA PRKACB	2.18e-04	37	114	4	M749
Pathway	REACTOME_RAP1_SIGNALLING	PRKACA PRKACB RASGRP2	2.18e-04	15	114	3	MM15019
Pathway	KEGG_MEDICUS_REFERENCE_EP_NE_ADRB_CAMP_SIGNALING_PATHWAY	ADCY9 PRKACA PRKACB	2.18e-04	15	114	3	M47794
Pathway	KEGG_MEDICUS_REFERENCE_PTH_PTH1R_PKA_SIGNALING_PATHWAY	ADCY9 PRKACA PRKACB	2.18e-04	15	114	3	M47504
Pathway	REACTOME_RET_SIGNALING	GRB7 SHANK3 PRKACA PRKACB	2.42e-04	38	114	4	MM15493
Pathway	KEGG_MEDICUS_REFERENCE_LHCGR_GNAS_PKA_SIGNALING_PATHWAY	ADCY9 PRKACA PRKACB	2.67e-04	16	114	3	M47645
Pathway	KEGG_MEDICUS_REFERENCE_FSHR_GNAS_PKA_SIGNALING_PATHWAY	ADCY9 PRKACA PRKACB	2.67e-04	16	114	3	M47650
Pathway	REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB	ADCY9 PRKACA PRKACB	2.67e-04	16	114	3	MM14492
Pathway	REACTOME_RAP1_SIGNALLING	PRKACA PRKACB RASGRP2	2.67e-04	16	114	3	M923
Pathway	REACTOME_G_PROTEIN_MEDIATED_EVENTS	ADCY9 GRK2 PRKACA PRKACB	2.68e-04	39	114	4	MM14496
Pathway	REACTOME_HEDGEHOG_OFF_STATE	DYNC2H1 PSMD2 PSMD5 ADCY9 PRKACA PRKACB	3.07e-04	113	114	6	M27471
Pathway	REACTOME_PKA_ACTIVATION_IN_GLUCAGON_SIGNALLING	ADCY9 PRKACA PRKACB	3.22e-04	17	114	3	M26995
Pathway	KEGG_MEDICUS_REFERENCE_CX3CR1_GNAI_AC_PKA_SIGNALING_PATHWAY	ADCY9 PRKACA PRKACB	3.22e-04	17	114	3	M47544
Pathway	REACTOME_DAG_AND_IP3_SIGNALING	ADCY9 GRK2 PRKACA PRKACB	3.26e-04	41	114	4	M512
Pathway	REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION	KIF27 DOCK9 KIFC2 PRKACA PRKACB MFN2	3.53e-04	116	114	6	MM15715
Pathway	WP_HEDGEHOG_SIGNALING_WP4249	GRK2 GRK3 PRKACA PRKACB	3.93e-04	43	114	4	M39706
Pathway	WP_VASOPRESSINREGULATED_WATER_REABSORPTION	DYNC2H1 ADCY9 PRKACA PRKACB	4.29e-04	44	114	4	M42554
Pathway	KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION	DYNC2H1 ADCY9 PRKACA PRKACB	4.29e-04	44	114	4	M9011
Pathway	WP_15Q25_COPY_NUMBER_VARIATION	SHANK3 SYNJ1 ZSCAN2 NMBR	5.09e-04	46	114	4	M48105
Pathway	REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB	ADCY9 PRKACA PRKACB	5.31e-04	20	114	3	M759
Pathway	REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_KEY_METABOLIC_FACTORS	PRKACA PRKACB	6.38e-04	5	114	2	M26988
Pathway	WP_CHEMOKINE_SIGNALING_PATHWAY	ADCY9 GRK2 TIAM1 PRKACA PRKACB PRKY RASGRP2	7.32e-04	184	114	7	MM15943
Pathway	KEGG_CHEMOKINE_SIGNALING_PATHWAY	ADCY9 GRK2 GRK3 TIAM1 PRKACA PRKACB RASGRP2	8.31e-04	188	114	7	M4844
Pathway	REACTOME_TRIGLYCERIDE_CATABOLISM	MGLL PRKACA PRKACB	9.21e-04	24	114	3	M10064
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_GNAS_TO_CRHR_PKA_ACTH_SIGNALING_PATHWAY	ADCY9 PRKACA PRKACB	9.21e-04	24	114	3	M47520
Pathway	REACTOME_G_PROTEIN_MEDIATED_EVENTS	ADCY9 GRK2 PRKACA PRKACB	9.40e-04	54	114	4	M26911
Pathway	REACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION	PRKACA PRKACB	9.52e-04	6	114	2	MM14628
Pathway	REACTOME_ACTIVATION_OF_NMDA_RECEPTORS_AND_POSTSYNAPTIC_EVENTS	PPM1E PRKACA PRKACB GRIN3A GRIN3B	9.81e-04	94	114	5	M2843
Pathway	REACTOME_INTRACELLULAR_SIGNALING_BY_SECOND_MESSENGERS	HDAC5 PSMD2 PSMD5 ADCY9 GRK2 LAMTOR4 PRKACA PRKACB PML	9.85e-04	313	114	9	M27867
Pathway	REACTOME_INTRACELLULAR_SIGNALING_BY_SECOND_MESSENGERS	PSMD2 PSMD5 ADCY9 GRK2 LAMTOR4 PRKACA PRKACB PML	1.01e-03	252	114	8	MM15585
Pathway	REACTOME_GLI3_IS_PROCESSED_TO_GLI3R_BY_THE_PROTEASOME	PSMD2 PSMD5 PRKACA PRKACB	1.15e-03	57	114	4	MM15205
Pathway	KEGG_MEDICUS_PATHOGEN_HCMV_UL33_TO_GNAI_AC_PKA_SIGNALING_PATHWAY	ADCY9 PRKACA PRKACB	1.17e-03	26	114	3	M47553
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR2F2 OR2M7 OR2M5 OR2M3 OR8G2P OR2T6 GRK3 PRKACA PRKACB OR5C1	1.21e-03	389	114	10	M14091
Pathway	KEGG_MEDICUS_REFERENCE_CRHR_PKA_ACTH_SIGNALING_PATHWAY	ADCY9 PRKACA PRKACB	1.31e-03	27	114	3	M47518
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_RASD1_TO_CRHR_PKA_ACTH_SIGNALING_PATHWAY	ADCY9 PRKACA PRKACB	1.31e-03	27	114	3	M47519
Pathway	KEGG_MEDICUS_REFERENCE_PKA_HOLOENZYME	PRKACA PRKACB	1.33e-03	7	114	2	M47896
Pathway	REACTOME_HDL_ASSEMBLY	PRKACA PRKACB	1.33e-03	7	114	2	MM15560
Pathway	REACTOME_DEGRADATION_OF_GLI1_BY_THE_PROTEASOME	PSMD2 PSMD5 PRKACA PRKACB	1.40e-03	60	114	4	M27470
Pathway	KEGG_MEDICUS_REFERENCE_GHRHR_PKA_GH_SIGNALING_PATHWAY	ADCY9 PRKACA PRKACB	1.46e-03	28	114	3	M47647
Pathway	KEGG_MEDICUS_REFERENCE_TSH_TG_SIGNALING_PATHWAY	ADCY9 PRKACA PRKACB	1.61e-03	29	114	3	M47627
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_GNAS_TO_ACTH_CORTISOL_SIGNALING_PATHWAY	ADCY9 PRKACA PRKACB	1.61e-03	29	114	3	M47515
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	HSPG2 KMT2B PCNX3 DOCK9 GRID1 PPARA ATG2A ZNF236 ABCA7 KIFC2 ST14 ADCY9 PCNX2 TBC1D16 INTS5 KMT2D KLHL25 CELSR3 UBN1 SYNJ1 NBEAL2 MFN2 RIC1 ZNF687	5.00e-10	1105	164	24	35748872
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	TIGAR TBC1D15 RPL35A PDPR WDR36 ANK2 MYO5A TMEM237 SYNM DYNC2H1 SLC6A15 CLPX PFKP DCAF5 ADCY9 MRPL17 TIAM1 NUP210 PRKACA PRKACB MACF1 TMEM131 UQCRC2 SNTB2 PML RAD21	8.24e-09	1487	164	26	33957083
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	ANK2 MYO5A DOCK9 PSMD2 DBN1 ABLIM3 ADCY9 PLPP6 SYNJ1 ARFGAP1 PRKACB MACF1 SNTB2	1.23e-08	347	164	13	17114649
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PDPR FLYWCH1 VPS13C CACHD1 ADGRV1 ATG2A ANKRD50 ADCY9 INTS5 CELSR3 NBEAL2 ZNF687 SEMA3E RAD21	2.46e-07	529	164	14	14621295
Pubmed	High-throughput microarray detection of olfactory receptor gene expression in the mouse.	OR2M7 OR2M5 OR2M3	4.10e-07	4	164	3	15377787
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	HSPG2 KMT2B ARRDC1 RNF213 GRID1 DBN1 CUL7 NUP210 MEGF11	8.87e-07	214	164	9	22199357
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	ANK2 MYO5A PPM1E DBN1 SHANK3 GRK3 SYNJ1 PRKACA PRKACB MACF1	9.93e-07	281	164	10	28706196
Pubmed	Human transcription factor protein interaction networks.	HSPG2 RPL35A KMT2B HDAC5 MYO5A PSMD2 DBN1 CUL7 CLPX PFKP DCAF5 MRPL17 KMT2D UBN1 ARFGAP1 ZBTB10 TMED9 UQCRC2 SNTB2 ZNF687 PML RAD21	1.11e-06	1429	164	22	35140242
Pubmed	The human immunodeficiency virus coat protein gp120 promotes forward trafficking and surface clustering of NMDA receptors in membrane microdomains.	PRKACA PRKACB GRIN3A GRIN3B	2.68e-06	21	164	4	22114277
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	CACHD1 THSD7B CUL7 TRIP12 CELSR3 SCAPER MACF1	2.96e-06	130	164	7	12421765
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	HSPG2 TBC1D15 MYO5A LAMA1 RNF213 PSMD2 PSMD5 TRIP12 ACTL8 FBXO31 MACF1 PML	3.36e-06	481	164	12	28190767
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SYNM DYNC2H1 RNF213 CUL7 ABLIM3 SHANK3 RASGRP3 NUP210 SCAPER MACF1 GRIN3A RIC1	4.31e-06	493	164	12	15368895
Pubmed	Phospho-tyrosine dependent protein-protein interaction network.	KMT2B SHFL GRB7 PPARA DBN1 ANKRD50 PLPP6 ARFGAP1 PRKACA SCAPER BRWD1	4.38e-06	410	164	11	25814554
Pubmed	Accumulation in fetal muscle and localization to the neuromuscular junction of cAMP-dependent protein kinase A regulatory and catalytic subunits RI alpha and C alpha.	ACHE PRKACA PRKACB	5.67e-06	8	164	3	8794865
Pubmed	Ellis-van Creveld Syndrome	DYNC2H1 PRKACA PRKACB	8.47e-06	9	164	3	37903214
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	RPF1 FLYWCH1 DOCK9 ANKRD50 ABLIM3 TRIP12 KIFC2 DCAF5 SYNJ1 ARFGAP1 SLC25A38 ZBTB10 MACF1 TMEM131 PML BRWD1 ZNF445	1.59e-05	1084	164	17	11544199
Pubmed	Evidence for a second isoform of the catalytic subunit of cAMP-dependent protein kinase.	PRKACA PRKACB	2.21e-05	2	164	2	3023318
Pubmed	Kabuki syndrome stem cell models reveal locus specificity of histone methyltransferase 2D (KMT2D/MLL4).	KMT2B KMT2D	2.21e-05	2	164	2	35640156
Pubmed	Investigation of -PRKACA/-PRKACB fusion genes in oncocytic tumors of the pancreatobiliary and other systems.	PRKACA PRKACB	2.21e-05	2	164	2	36152045
Pubmed	PRKACA/PRKACB Fusions in Pancreatobiliary Intraductal Oncocytic Papillary Neoplasms Including Those With Atypical Morphology: An Analysis of 22 Cases Expanding Morphologic Spectrum.	PRKACA PRKACB	2.21e-05	2	164	2	38841868
Pubmed	Evidence of a dosage effect and a physiological endplate acetylcholinesterase deficiency in the first mouse models mimicking Schwartz-Jampel syndrome neuromyotonia.	HSPG2 ACHE	2.21e-05	2	164	2	18647752
Pubmed	Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3.	GRK2 GRK3	2.21e-05	2	164	2	10198406
Pubmed	Loss of CSMD1 or 2 may contribute to the poor prognosis of colorectal cancer patients.	CSMD2 CSMD1	2.21e-05	2	164	2	24408017
Pubmed	G-protein coupled receptor kinase 2 and 3 expression in human detrusor cultured smooth muscle cells.	GRK2 GRK3	2.21e-05	2	164	2	11762794
Pubmed	Molecular and behavioral effects of a null mutation in all PKA C beta isoforms.	PRKACA PRKACB	2.21e-05	2	164	2	12139926
Pubmed	Characterization of genomic clones coding for the C alpha and C beta subunits of mouse cAMP-dependent protein kinase.	PRKACA PRKACB	2.21e-05	2	164	2	2833513
Pubmed	Cloning of GRK2 cDNA from S49 murine lymphoma cells.	GRK2 GRK3	2.21e-05	2	164	2	8638670
Pubmed	Acidic glycosaminoglycans and laminin-1 in renal corpuscles of mutant blebs (my) and control mice.	LAMA1 FREM2	2.21e-05	2	164	2	9302549
Pubmed	Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells.	GRK2 GRK3	2.21e-05	2	164	2	33060647
Pubmed	Global consequences of activation loop phosphorylation on protein kinase A.	PRKACA PRKACB	2.21e-05	2	164	2	19965870
Pubmed	Nucleotide sequence, genomic organization, and chromosomal localization of genes encoding the human NMDA receptor subunits NR3A and NR3B.	GRIN3A GRIN3B	2.21e-05	2	164	2	11735224
Pubmed	G protein--coupled receptor kinases.	GRK2 GRK3	2.21e-05	2	164	2	8035170
Pubmed	Protein kinase A translocation and insulin secretion in pancreatic beta-cells: studies with adenylate cyclase toxin from Bordetella pertussis.	PRKACA PRKACB	2.21e-05	2	164	2	12180908
Pubmed	Interaction of acetylcholinesterase with the G4 domain of the laminin alpha1-chain.	ACHE LAMA1	2.21e-05	2	164	2	18215127
Pubmed	Recurrent Rearrangements in PRKACA and PRKACB in Intraductal Oncocytic Papillary Neoplasms of the Pancreas and Bile Duct.	PRKACA PRKACB	2.21e-05	2	164	2	31678302
Pubmed	Systems-level identification of PKA-dependent signaling in epithelial cells.	PRKACA PRKACB	2.21e-05	2	164	2	28973931
Pubmed	A genetic association study of CSMD1 and CSMD2 with cognitive function.	CSMD2 CSMD1	2.21e-05	2	164	2	27890662
Pubmed	Comparison of methylation episignatures in KMT2B- and KMT2D-related human disorders.	KMT2B KMT2D	2.21e-05	2	164	2	35506254
Pubmed	The complement control-related genes CSMD1 and CSMD2 associate to schizophrenia.	CSMD2 CSMD1	2.21e-05	2	164	2	21439553
Pubmed	Gene Rearrangement and Expression of PRKACA and PRKACB Govern Morphobiology of Pancreatobiliary Oncocytic Neoplasms.	PRKACA PRKACB	2.21e-05	2	164	2	37871652
Pubmed	Genetic variation in N-methyl-D-aspartate receptor subunit NR3A but not NR3B influences susceptibility to Alzheimer's disease.	GRIN3A GRIN3B	2.21e-05	2	164	2	20016182
Pubmed	Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79.	GRK2 PRKACA	2.21e-05	2	164	2	11278469
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	KBTBD3 TIGAR MYO5A VPS13C RNF213 MGLL ATP9B PPARA ADGRV1 ZNF236 CERT1 PCNX2 ZBTB46 GRK3 NUP210 PRKACB MACF1 CSMD1 ALG12 RIC1	2.58e-05	1489	164	20	28611215
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	TRAF2 TBC1D15 RPL35A PDPR WDR36 SYNM VPS13C RNF213 PSMD2 CUL7 CLPX NDUFB7 ADCY9 MRPL17 RPUSD3 PRKACA MFN2 TMEM131 UQCRC2 RAD21	2.76e-05	1496	164	20	32877691
Pubmed	The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.	TRAF2 WDR36 KMT2B RNF213 PSMD2 INTS5 ZNF687 PML	3.70e-05	262	164	8	36880596
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PDPR MYO5A PPM1E RNF213 PSMD2 SLC6A15 CACHD1 CUL7 CLPX ADCY9 KMT2D TIAM1 NUP210 PRKACA UQCRC2 SNTB2	3.98e-05	1049	164	16	27880917
Pubmed	cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes.	ADCY9 PRKACA PRKACB	4.49e-05	15	164	3	2165385
Pubmed	Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.	PSMD5 CUL7 TRIP12 RAD21	4.64e-05	42	164	4	7584044
Pubmed	Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects.	HSPG2 LAMA1 FREM2	5.51e-05	16	164	3	16880404
Pubmed	The C-terminal cytoplasmic tail of hedgehog receptor Patched1 is a platform for E3 ubiquitin ligase complexes.	PSMD2 CLPX GRK2 GRK3 TMEM131	5.61e-05	86	164	5	26885983
Pubmed	Identification of different proteins binding to Na, K-ATPase α1 in LPS-induced ARDS cell model by proteomic analysis.	WDR36 RNF213 PSMD2 PFKP TRIP12 UQCRC2	6.54e-05	144	164	6	35681168
Pubmed	Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309.	GRK2 GRK3	6.61e-05	3	164	2	10754297
Pubmed	Identification of two new members of the CSMD gene family.	CSMD2 CSMD1	6.61e-05	3	164	2	12906867
Pubmed	Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase.	PRKACA PRKACB	6.61e-05	3	164	2	2342480
Pubmed	Participation of myosin Va and Pka type I in the regeneration of neuromuscular junctions.	MYO5A PRKACA	6.61e-05	3	164	2	22815846
Pubmed	Regulation of SIK1 abundance and stability is critical for myogenesis.	HDAC5 PRKACA	6.61e-05	3	164	2	23256157
Pubmed	Combined PGE2 with TNF-α promotes laryngeal carcinoma progression by enhancing GRK2 and TRAF2 interaction.	TRAF2 GRK2	6.61e-05	3	164	2	31986892
Pubmed	A genetic test of the effects of mutations in PKA on mossy fiber LTP and its relation to spatial and contextual learning.	PRKACA PRKACB	6.61e-05	3	164	2	8548807
Pubmed	The paradoxical increase in cortisol secretion induced by dexamethasone in primary pigmented nodular adrenocortical disease involves a glucocorticoid receptor-mediated effect of dexamethasone on protein kinase A catalytic subunits.	PRKACA PRKACB	6.61e-05	3	164	2	19383776
Pubmed	Human acetylcholinesterase binds to mouse laminin-1 and human collagen IV by an electrostatic mechanism at the peripheral anionic site.	ACHE LAMA1	6.61e-05	3	164	2	12524166
Pubmed	Association of a RING finger protein with the cytoplasmic domain of the human type-2 tumour necrosis factor receptor.	TRAF2 PSMD2	6.61e-05	3	164	2	7639698
Pubmed	Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus.	GRK2 GRK3	6.61e-05	3	164	2	10085131
Pubmed	Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor.	GRK2 GRK3	6.61e-05	3	164	2	7761854
Pubmed	Histone methyltransferase MLL4 controls myofiber identity and muscle performance through MEF2 interaction.	KMT2B KMT2D	6.61e-05	3	164	2	32544095
Pubmed	The N-termini of GRK2 and GRK3 simulate the stimulating effects of RKIP on β-adrenoceptors.	GRK2 GRK3	6.61e-05	3	164	2	31604529
Pubmed	Active cAMP-dependent protein kinase incorporated within highly purified HIV-1 particles is required for viral infectivity and interacts with viral capsid protein.	PRKACA PRKACB	6.61e-05	3	164	2	12842892
Pubmed	The histone methyltransferase KMT2B is required for RNA polymerase II association and protection from DNA methylation at the MagohB CpG island promoter.	KMT2B KMT2D	6.61e-05	3	164	2	23358417
Pubmed	Involvement of the catalytic subunit of protein kinase A and of HA95 in pre-mRNA splicing.	PRKACA PRKACB	6.61e-05	3	164	2	17594903
Pubmed	Orphanin FQ/nociceptin-mediated desensitization of opioid receptor-like 1 receptor and mu opioid receptors involves protein kinase C: a molecular mechanism for heterologous cross-talk.	GRK2 GRK3	6.61e-05	3	164	2	12130708
Pubmed	MACF1 links Rapsyn to microtubule- and actin-binding proteins to maintain neuromuscular synapses.	RAPSN MACF1	6.61e-05	3	164	2	30842214
Pubmed	Epidermal growth factor receptor levels are reduced in mice with targeted disruption of the protein kinase A catalytic subunit.	PRKACA PRKACB	6.61e-05	3	164	2	18380891
Pubmed	Regulation of melanocortin-4 receptor signaling: agonist-mediated desensitization and internalization.	GRK2 PRKACA	6.61e-05	3	164	2	12639913
Pubmed	PKA phosphorylates histone deacetylase 5 and prevents its nuclear export, leading to the inhibition of gene transcription and cardiomyocyte hypertrophy.	HDAC5 PRKACA	6.61e-05	3	164	2	20716686
Pubmed	Misregulation of an Activity-Dependent Splicing Network as a Common Mechanism Underlying Autism Spectrum Disorders.	DYNC2H1 VPS13C SYNJ1	7.97e-05	18	164	3	27984743
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	RPL35A WDR36 KMT2B FLYWCH1 PCNX3 MYO5A PFKP ECT2 PLPP6 INTS5 RPUSD3 PRKACA PTRH1 MACF1 TMED9 UQCRC2 SNTB2 ZNF687 RAD21	8.82e-05	1497	164	19	31527615
Pubmed	Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis.	KMT2B KMT2D UTY	1.11e-04	20	164	3	19047629
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	WDR36 MYO5A ARRDC1 LAMA1 PSMD2 CUL7 CLPX SNTB2	1.28e-04	313	164	8	38270169
Pubmed	Regulation of the protocadherin Celsr3 gene and its role in globus pallidus development and connectivity.	ACHE CELSR3 RAD21	1.29e-04	21	164	3	25113559
Pubmed	Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube.	DYNC2H1 PRKACA PRKACB	1.29e-04	21	164	3	22007132
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	MYO5A LAMA1 DBN1 TRIP12 KMT2D MACF1 UTY	1.30e-04	234	164	7	36243803
Pubmed	Crucial roles for interactions between MLL3/4 and INI1 in nuclear receptor transactivation.	KMT2B KMT2D	1.32e-04	4	164	2	19221051
Pubmed	Endorepellin remodels the endothelial transcriptome toward a pro-autophagic and pro-mitophagic gene signature.	HSPG2 MFN2	1.32e-04	4	164	2	29921586
Pubmed	Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans.	ABCA7 GRIN3B	1.32e-04	4	164	2	23571587
Pubmed	Exome sequencing in seven families and gene-based association studies indicate genetic heterogeneity and suggest possible candidates for fibromuscular dysplasia.	DYNC2H1 RNF213	1.32e-04	4	164	2	26147384
Pubmed	Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function.	GRK2 GRK3	1.32e-04	4	164	2	8917529
Pubmed	GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor.	PRKACA PRKACB	1.32e-04	4	164	2	31112131
Pubmed	Discrete control of TRPV4 channel function in the distal nephron by protein kinases A and C.	PRKACA PRKACB	1.32e-04	4	164	2	23709216
Pubmed	Hierarchical organization of multi-site phosphorylation at the CXCR4 C terminus.	GRK2 GRK3	1.32e-04	4	164	2	23734232
Pubmed	Germline and Mosaic Variants in PRKACA and PRKACB Cause a Multiple Congenital Malformation Syndrome.	PRKACA PRKACB	1.32e-04	4	164	2	33058759
Pubmed	Differential role of PKA catalytic subunits in mediating phenotypes caused by knockout of the Carney complex gene Prkar1a.	PRKACA PRKACB	1.32e-04	4	164	2	21852354
Pubmed	MLL2 is required in oocytes for bulk histone 3 lysine 4 trimethylation and transcriptional silencing.	KMT2B KMT2D	1.32e-04	4	164	2	20808952
Pubmed	Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice.	KMT2B KMT2D	1.32e-04	4	164	2	23826075
Pubmed	Reduced expression of G protein-coupled receptor kinases in schizophrenia but not in schizoaffective disorder.	GRK2 GRK3	1.32e-04	4	164	2	21784156
Pubmed	Non-enzymatic developmental functions of acetylcholinesterase--the question of redundancy.	ACHE LAMA1	1.32e-04	4	164	2	18785927
Pubmed	Protein kinase A-induced phosphorylation of the p65 subunit of nuclear factor-kappaB promotes Schwann cell differentiation into a myelinating phenotype.	PRKACA PRKACB	1.32e-04	4	164	2	18385332
Pubmed	A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.	KMT2B KMT2D	1.32e-04	4	164	2	23129768
Pubmed	Cloning of a mouse protein kinase A catalytic subunit pseudogene and chromosomal mapping of C subunit isoforms.	PRKACA PRKACB	1.32e-04	4	164	2	7873880
Pubmed	NR2 to NR3B subunit switchover of NMDA receptors in early postnatal motoneurons.	GRIN3A GRIN3B	1.32e-04	4	164	2	15813953
Pubmed	Glucose-dependent regulation of AMP-activated protein kinase in MIN6 beta cells is not affected by the protein kinase A pathway.	PRKACA PRKACB	1.32e-04	4	164	2	23116618
Pubmed	Role of caveolin-1 in the modulation of lipolysis and lipid droplet formation.	PRKACA PRKACB	1.32e-04	4	164	2	15111495
Interaction	TOP3B interactions	HSPG2 WDR36 KMT2B PCNX3 DOCK9 GRID1 PPARA ATG2A CLPX PFKP ZNF236 ABCA7 KIFC2 ST14 ADCY9 PCNX2 TBC1D16 INTS5 KMT2D KLHL25 CELSR3 UBN1 SYNJ1 NBEAL2 PRKACA MFN2 RIC1 ZNF687	7.83e-06	1470	156	28	int:TOP3B
Interaction	TAFA5 interactions	LRRC4B ADGRV1 FREM2 DCBLD2	9.71e-06	18	156	4	int:TAFA5
Interaction	PSG8 interactions	TBC1D15 PDPR ADGRV1 FREM2 CELSR3	1.56e-05	41	156	5	int:PSG8
Cytoband	1q44	OR2M7 OR2M5 OR2M3 OR2T6 PGBD2	4.95e-05	110	164	5	1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr1q44	OR2M7 OR2M5 OR2M3 OR2T6 PGBD2	1.02e-04	128	164	5	chr1q44
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	DOCK9 ASAP3 GRB7 CERT1 GRK2 GRK3 TIAM1	3.49e-04	206	115	7	682
GeneFamily	Olfactory receptors, family 2	OR2F2 OR2M7 OR2M5 OR2M3 OR2T6	7.76e-04	113	115	5	149
GeneFamily	Glutamate ionotropic receptor NMDA type subunits	GRIN3A GRIN3B	8.25e-04	7	115	2	1201
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SHFL ATP9B CUL7 PFKP DCAF5 TMEM178A RPUSD3 ZBTB10	4.41e-07	186	163	8	39e475a3c167b33daa63b0c1bfa32451c5f46635
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SHFL ATP9B CUL7 PFKP DCAF5 TMEM178A RPUSD3 ZBTB10	4.41e-07	186	163	8	02418c50fdcca549bf73dedf6199ab4a27862a9b
ToppCell	E16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CLPX KLHL25 FBXO31 NBEAL2 DCBLD2 ALG12 SEMA3E	4.77e-06	181	163	7	f6629fa71bb94405f523f63a9264cacf6d15c5f4
ToppCell	droplet-Heart-4Chambers-18m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF27 GRB7 MATN4 ST14 FREM2 SLC44A3 SEMA3E	5.31e-06	184	163	7	6388c47b7f1d8203e3069eba0e74107256dcae51
ToppCell	droplet-Heart-4Chambers-18m-Neuronal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF27 GRB7 MATN4 ST14 FREM2 SLC44A3 SEMA3E	5.31e-06	184	163	7	d83ae1dc64aa1b27d3b524c137567418cc0ff8c6
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	LAMA1 GRB7 ADGRV1 ST14 FREM2 NUP210 SLC44A3	7.02e-06	192	163	7	d3634574b2e8d2ded6446969361b70761b331aea
ToppCell	PCW_07-8.5-Epithelial-Epithelial_alveolar-distal\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	LAMA1 GRB7 ADGRV1 ST14 FREM2 NUP210 SLC44A3	7.02e-06	192	163	7	b7c01e12b3e9be960a741b08835f1dfff65d0d47
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	LAMA1 GRB7 ADGRV1 ST14 FREM2 NUP210 SLC44A3	7.02e-06	192	163	7	1aa5e4d9b32013a3f272561dcb8377f6805706df
ToppCell	PCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_CTGF^high_distal_(3)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	LAMA1 GRB7 ADGRV1 ST14 FREM2 NUP210 SLC44A3	7.26e-06	193	163	7	ab78fb1603ea6f720ba2d30148fe65dccf271fe1
ToppCell	PCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^medium_distal_(2)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	LAMA1 GRB7 ADGRV1 ST14 FREM2 NUP210 SLC44A3	7.51e-06	194	163	7	413112ee8df7407fd418d57c2ff11aad3a6ec259
ToppCell	PCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	MYO5A LAMA1 GRB7 ADGRV1 ST14 FREM2 MEGF11	7.51e-06	194	163	7	c47fc3f716ab091a39c20d7639ac783029589ee5
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_cytotoxic-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GIMAP5 RNF213 PPARA NUP210 MFN2 NLRC3 PRKY	7.76e-06	195	163	7	83c125223e7ca0f08a31414b3a16347912564765
ToppCell	PCW_10-12-Epithelial-Epithelial_proliferating\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	LAMA1 GRB7 ADGRV1 ST14 FREM2 NUP210 SLC44A3	7.76e-06	195	163	7	ce1ba5911e8a6ddb07434acc37147c38e94245ff
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DYNC2H1 VPS13C GRK3 SYNJ1 SCAPER MACF1 UTY	7.76e-06	195	163	7	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	PCW_13-14-Epithelial-Epithelial_alveolar-distal\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	MYO5A GRB7 ADGRV1 ST14 FREM2 MEGF11 SLC44A3	8.30e-06	197	163	7	6852a8ec1397811bbdd1fc625c52ed4fa75a931e
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1-AT1_L.0.5.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HSPG2 ACHE MGLL MS4A15 ABCA7 NBEAL2	3.75e-05	169	163	6	cd16e8462ee09877be962fbd9a3badcb825820b0
ToppCell	droplet-Thymus-nan-21m-Lymphocytic-B_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KMT2B MYO5A PPM1E MGLL CUL7 TBC1D16	4.27e-05	173	163	6	0a0cd40bb5f61431fe34758626c8a63ec610a8a5
ToppCell	wk_15-18-Epithelial-Distal_epithelial-type_I_pneumocyte\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	HSPG2 TMEM207 ADGRV1 FREM2 TMEM191B UPK2	4.41e-05	174	163	6	2cd6638b361ca05ab83d09ce657194aed97873b7
ToppCell	droplet-Liver-Npc-21m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 FLYWCH1 ACHE SHANK3 TIAM1 RASGRP3	5.66e-05	182	163	6	dc55de945c6f78f32eb3a1b3520835eb8417e068
ToppCell	droplet-Liver-Npc-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 FLYWCH1 ACHE SHANK3 TIAM1 RASGRP3	5.66e-05	182	163	6	010a7364da46101cb5068891fd7bc712ea8f13bd
ToppCell	droplet-Liver-Npc-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 FLYWCH1 ACHE SHANK3 TIAM1 RASGRP3	5.66e-05	182	163	6	b1ec2015aad1181eac1bbf8d48ad6f2f7ed24a01
ToppCell	COVID-19-lung-AT1\|lung / Disease (COVID-19 only), tissue and cell type	MGLL MS4A15 ADGRV1 NBEAL2 SLC44A3 SEMA3E	5.84e-05	183	163	6	942530449e9c6583705eeb8f6f12621daea57252
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZAN LAMA1 GRID1 ADGRV1 FREM2 CSMD1	6.02e-05	184	163	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZAN LAMA1 GRID1 ADGRV1 FREM2 CSMD1	6.02e-05	184	163	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZAN LAMA1 GRID1 ADGRV1 FREM2 CSMD1	6.02e-05	184	163	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Neuronal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACHE MATN4 ZSCAN2 EGFLAM CSMD1 SEMA3E	6.02e-05	184	163	6	e33bb572af9dfd11127105f1ac99bc958a7cafbb
ToppCell	nucseq-Immune-Immune_Myeloid-Myeloid_Dendritic-maDC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ACHE ZBTB46 GRK3 TIAM1 YPEL5 ZBTB10	6.20e-05	185	163	6	7e3d9f5050e71e91021245c11101e994ae41d22b
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	WDR36 VPS13C RNF213 KMT2D MACF1 UTY	6.20e-05	185	163	6	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	Substantia_nigra-Neuronal\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	SLC6A15 ABLIM3 KIFC2 CELSR3 SYNJ1 PRKACB	6.39e-05	186	163	6	3f889083fcffe516388e9b03a5e23af2010ced33
ToppCell	critical-Myeloid-Monocyte-derived_Macrophage\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SHFL GIMAP5 ASAP3 RNF213 PFKP PML	6.58e-05	187	163	6	72e4aec49ea0c5fe6cee2a1a46369dbc90cd3fad
ToppCell	PCW_13-14-Endothelial-Endothelial_immature-endo_immature_arterial2_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	HSPG2 DOCK9 THSD7B SHANK3 TMEM178A RASGRP3	6.77e-05	188	163	6	b66f1f08827dd6c48583d871f9f33ea41e48bfb2
ToppCell	PCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	LAMA1 GRB7 ADGRV1 ST14 FREM2 NUP210	6.98e-05	189	163	6	5d9da836ce4308b8458bb3be3871a0aca734b6cd
ToppCell	COVID-19-Heart-EC_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	HSPG2 DOCK9 MGLL ABLIM3 SHANK3 RASGRP3	6.98e-05	189	163	6	fe49852ba15f948b384d6b4c258927c70b741357
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_intermediate_(1)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ADGRV1 ST14 FREM2 NUP210 SLC44A3 SEMA3E	7.18e-05	190	163	6	c95032bb3ee2b3d40fdf48016acb46d6f78a48a6
ToppCell	facs-Pancreas-Exocrine-3m-Endothelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 GIMAP5 MGLL ABLIM3 SHANK3 RASGRP3	7.18e-05	190	163	6	b7fc451e160e31dc898b122de844b501f587db67
ToppCell	PCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	LAMA1 ADGRV1 ST14 FREM2 NUP210 SLC44A3	7.18e-05	190	163	6	625c08a0e5227efc46daa512fd579c3938ff76c7
ToppCell	facs-Pancreas-Exocrine-3m-Endothelial-endothelial_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 GIMAP5 MGLL ABLIM3 SHANK3 RASGRP3	7.18e-05	190	163	6	83cc851fb9f644b17a8ebf4d99a646003769a22f
ToppCell	PCW_10-12-Endothelial-Endothelial_immature-endo_immature_arterial2_(6)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	HSPG2 DOCK9 THSD7B SHANK3 TMEM178A RASGRP3	7.18e-05	190	163	6	7ba2be2630183df86de21689289a8620a4cd507e
ToppCell	facs-Pancreas-Exocrine-3m-Endothelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 GIMAP5 MGLL ABLIM3 SHANK3 RASGRP3	7.18e-05	190	163	6	5f440d4b334d66d419c03bd828f7d93f16c1ce67
ToppCell	COVID-19-kidney-TAL\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PPM1E LAMA1 GRB7 MGLL PFKP MEGF11	7.39e-05	191	163	6	fe55475ce0666ab5122447a813dc2369e24947b8
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	LAMA1 GRB7 ADGRV1 ECT2 FREM2 SLC44A3	7.61e-05	192	163	6	25378b5e4b0cea8415ff125783511fc25a56fc00
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_CTGF^high_distal_(3)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	LAMA1 GRB7 ADGRV1 ST14 FREM2 SLC44A3	7.61e-05	192	163	6	39804d9ddc67c1b41887752df2503389eae44a1a
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	DOCK9 RNF213 ATP9B MACF1 UTY PRKY	7.61e-05	192	163	6	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating1_(8)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	LAMA1 GRB7 ADGRV1 ST14 FREM2 SLC44A3	7.83e-05	193	163	6	979980369d2dbee9dc4770d72b93037abd7786eb
ToppCell	severe-low-quality_cells\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	GIMAP5 RNF213 CD84 SCAPER MACF1 BRWD1	7.83e-05	193	163	6	9337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCell	PCW_05-06-Epithelial-Epithelial_proliferating\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	GRB7 ADGRV1 ST14 FREM2 NUP210 SLC44A3	7.83e-05	193	163	6	5f0eba7b1440beb891d94a288f7f18a4e13c3a88
ToppCell	droplet-Kidney-nan-21m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAPSN ANK2 MGLL DBN1 ST14 AEBP1	7.83e-05	193	163	6	b397c14ac1e34c6be3f25d4417d200bc518d3048
ToppCell	droplet-Kidney-nan-21m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAPSN ANK2 MGLL DBN1 ST14 AEBP1	7.83e-05	193	163	6	241a60d1f0d5832638fb3e1e4b7afa7387ea3c75
ToppCell	PCW_05-06-Epithelial-Epithelial_alveolar-distal\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	GRB7 ADGRV1 ST14 FREM2 NUP210 SLC44A3	8.06e-05	194	163	6	acd5ba9a097595d4caab4f05440531c65a4aa7bc
ToppCell	PCW_05-06-Epithelial\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	GRB7 ADGRV1 ST14 FREM2 NUP210 SLC44A3	8.06e-05	194	163	6	47a1369c22fcbfe00b08376eb610a61c355548db
ToppCell	PCW_10-12-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	LAMA1 ADGRV1 ST14 FREM2 NUP210 SLC44A3	8.29e-05	195	163	6	98dd3b7d5ef587825dac052dea4d4ff883f6d4d6
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^medium_distal_(2)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	MYO5A GRB7 ADGRV1 FREM2 MEGF11 SLC44A3	8.29e-05	195	163	6	f08e41706680881ebd0afcd08a02f8ac0089f04e
ToppCell	facs-Heart-RA-3m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GIMAP5 DOCK9 MGLL ABLIM3 SHANK3 RASGRP3	8.29e-05	195	163	6	f4fdcc0b851392086e9618e76ee6a0b540d5fb3c
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HSPG2 MGLL MS4A15 ABCA7 NBEAL2 SEMA3E	8.29e-05	195	163	6	68f4cc84b5ae7f4159b780c78e4b66c94211779a
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HSPG2 MGLL MS4A15 ABCA7 NBEAL2 SEMA3E	8.29e-05	195	163	6	2a1863f4b9fe73c30b0b1acf9b12fc98ef65040f
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DYNC2H1 VPS13C GRK3 SCAPER MACF1 UTY	8.29e-05	195	163	6	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	3'_v3-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8\|bone_marrow / Manually curated celltypes from each tissue	RNF213 MACF1 NLRC3 PRKY SLC44A3	8.31e-05	121	163	5	19333a660800b583fa27b495c1f7828e6636a257
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	LAMA1 GRB7 ADGRV1 ST14 FREM2 SLC44A3	8.52e-05	196	163	6	0a34a0009f479384f1994c6f977f942699a132c8
ToppCell	PCW_13-14-Epithelial-Epithelial_proliferating\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	GRB7 ADGRV1 ST14 FREM2 NUP210 SLC44A3	8.52e-05	196	163	6	7b17d47b7758d8ccf9dbefd097aeb553791a1eed
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1-AT1_L.0.5.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HSPG2 MGLL MS4A15 ABCA7 NBEAL2 SEMA3E	8.52e-05	196	163	6	eb68f7954e7c2f86d05e740e95b6e74805a6053f
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 DOCK9 CACHD1 SHANK3 ZBTB46 RASGRP3	8.52e-05	196	163	6	adee900dcd16dbaba15c58bdcace09ba20214950
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Syt6\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	THSD7B PNPLA1 TMEM178A ALDH3A1 SEMA3E	8.64e-05	122	163	5	37612ad087d9c11d4a3466244ab36224de31930b
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	VPS13C MROH5 GRB7 ADGRV1 CSMD2 SLC44A3	8.76e-05	197	163	6	b94645d57efe8d9e032bffb8c89af1f425c6421e
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	MYO5A LAMA1 GRB7 ADGRV1 FREM2 SLC44A3	8.76e-05	197	163	6	22b26bac3a99b20c73bfa6e6f81026d064eaa9e8
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Layer_VI_Pan-area\|World / Primary Cells by Cluster	DOCK9 MGLL GRK3 TMEM178A PRKACB SEMA3E	8.76e-05	197	163	6	79b9e7f2e8e33b3c547f716be5667156c48b0dfc
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Layer_VI_Pan-area-33\|World / Primary Cells by Cluster	DOCK9 MGLL GRK3 TMEM178A PRKACB SEMA3E	8.76e-05	197	163	6	d20f29088e9afd8a960d6f680075c380e550f8a7
ToppCell	PCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^medium_distal_(2)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	GRB7 ADGRV1 ST14 FREM2 MEGF11 SLC44A3	8.76e-05	197	163	6	2f91b3870a7058168093a143110954c07588cfe9
ToppCell	LV-09._Endothelium_I\|LV / Chamber and Cluster_Paper	HSPG2 DOCK9 MGLL ABLIM3 SHANK3 ZBTB46	8.76e-05	197	163	6	f9731d4d636e51b94a96805eee6afe9aedc175e3
ToppCell	Parenchymal-10x3prime_v2-Stromal-Mesofibroblastic\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ANK2 TMEM237 LAMA1 THSD7B CSMD2 AEBP1	9.01e-05	198	163	6	0cd930e374c2c48d1991b51c025f9801b22ecee7
ToppCell	Parenchymal-10x3prime_v2-Stromal-Mesofibroblastic-Mesothelia\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ANK2 TMEM237 LAMA1 THSD7B CSMD2 AEBP1	9.01e-05	198	163	6	e0df6d6ff2a9c41d813f84a2a5ee7cb5f6fc3e30
ToppCell	Frontal_cortex-Neuronal\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	FLYWCH1 MYO5A SLC6A15 CELSR3 SYNJ1 PRKACA	9.26e-05	199	163	6	f88039d862f3bfa01dc39d2de4f3f548dc5a0e61
ToppCell	TCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma\|TCGA-Liver / Sample_Type by Project: Shred V9	TRAF2 PCNX3 CUL7 TBC1D16 ARFGAP1 TMED9	9.52e-05	200	163	6	9cff8be6e566f342fc8b45e93106d033b14759ee
ToppCell	Parenchymal-10x5prime-Stromal-Peri/Epineurial_-NAF_epineurial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SYNM ASAP3 ABLIM3 TBC1D16 EGFLAM ZNF445	9.52e-05	200	163	6	36de49593cf6ff1c9229fcceb150c1d68658a360
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_alveolar-AT1\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	GRB7 MGLL MS4A15 ABCA7 NBEAL2 SEMA3E	9.52e-05	200	163	6	3d51aebf626dd4656ab4aac8a20d761b8062c42d
ToppCell	TCGA-Liver-Primary_Tumor\|TCGA-Liver / Sample_Type by Project: Shred V9	TRAF2 PCNX3 CUL7 TBC1D16 ARFGAP1 TMED9	9.52e-05	200	163	6	b667168081393433597f6ca8baeddba1d1906d40
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocye.Tnr.Cspg5_(Cspg5)\|Striatum / BrainAtlas - Mouse McCarroll V32	ZAN TKTL2 GRIN3B HCRT	1.26e-04	70	163	4	c6d3f8cd3f79e2beb826b07a6b9f3ab35d4f23ea
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocye.Tnr.Cspg5_(Cspg5)-\|Striatum / BrainAtlas - Mouse McCarroll V32	ZAN TKTL2 GRIN3B HCRT	1.26e-04	70	163	4	823921f8bf585d45f24f627b2b77b228898eb85a
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P3-Tnr\|Striatum / BrainAtlas - Mouse McCarroll V32	ZAN TKTL2 GRIN3B HCRT	1.26e-04	70	163	4	d2be16550c572ba77261c978648e61dba3eab6bd
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P3\|Striatum / BrainAtlas - Mouse McCarroll V32	ZAN TKTL2 GRIN3B HCRT	1.26e-04	70	163	4	52bde49a05f2387fe3e4357422e155bee2e86ae6
ToppCell	3'_v3-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	PPM1E RNF213 ATG2A CD84 MACF1	1.39e-04	135	163	5	ae2d3a42e567b5bade304c0caa497eb725be3565
ToppCell	356C-Epithelial_cells-Epithelial-C_(AT2)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	RPF1 KLHL25 CELSR3 GFOD2 PGBD2	1.82e-04	143	163	5	b74571d30def54a0524c8d95a3bc9d3439319eb4
ToppCell	356C-Epithelial_cells-Epithelial-C_(AT2)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	RPF1 KLHL25 CELSR3 GFOD2 PGBD2	1.82e-04	143	163	5	5c81b238be53f010d691d0c59c1c29cb52222ed3
Drug	4-isopropylaniline	ACHE ADGRV1 ADCY9 GRK2 GRK3 PRKACA PRKACB	6.77e-07	71	160	7	CID000007464
Drug	7B-forskolin	ADCY9 GRK2 GRK3 PRKACA PRKACB	9.40e-07	26	160	5	CID000130638
Drug	8-N3cAMP	GRK2 GRK3 PRKACA PRKACB	2.23e-06	14	160	4	CID006426627
Drug	8-(6-aminohexyl)amino cyclic AMP	GRK2 GRK3 PRKACA PRKACB	2.23e-06	14	160	4	CID000161999
Drug	NA-382	GRK2 GRK3 PRKACA PRKACB	3.02e-06	15	160	4	CID000132534
Drug	N6-monobutyryl-cAMP	ADCY9 GRK2 GRK3 PRKACA PRKACB	3.26e-06	33	160	5	CID000115029
Drug	AC1L1GTT	HDAC5 GRB7 ADCY9 GRK2 GRK3 TIAM1 PRKACA PTRH1 PRKACB GRIN3B	6.19e-06	233	160	10	CID000003837
Drug	8-azido cyclic AMP	GRK2 GRK3 PRKACA PRKACB	6.66e-06	18	160	4	CID000115296
Drug	8-azidoadenosine	GRK2 GRK3 PRKACA PRKACB	8.39e-06	19	160	4	CID000160751
Drug	8-thiomethyl-cAMP	GRK2 GRK3 PRKACA PRKACB	8.39e-06	19	160	4	CID000093140
Drug	AC1L19C4	TIGAR PFKP GRK2 GRK3 PRKACA PRKACB	9.12e-06	69	160	6	CID000000483
Drug	amrinone	ADCY9 GRK2 GRK3 PRKACA PRKACB	1.25e-05	43	160	5	CID000003698
Drug	SKF 38393	ADCY9 GRK2 GRK3 CELSR3 PRKACA PRKACB GRIN3B	1.29e-05	110	160	7	CID000001242
Drug	p,p'-DDA	ADCY9 GRK2 GRK3 PRKACA PTRH1 PRKACB	1.37e-05	74	160	6	CID000006730
Drug	Sp-8-Cl-cAMPS	GRK2 GRK3 PRKACA PRKACB	1.56e-05	22	160	4	CID000133987
Drug	SCH 23390	ADCY9 GRK2 GRK3 PRKACA PRKACB GRIN3B HCRT	1.82e-05	116	160	7	CID000005018
Drug	terbutaline	MGLL ADCY9 GRK2 GRK3 PRKACA PRKACB	2.14e-05	80	160	6	CID000005403
Drug	H 85	GRK2 GRK3 PRKACA PRKACB	3.11e-05	26	160	4	CID006439306
Drug	memantine	ACHE GRID1 DBN1 GRIN3A GRIN3B NMBR	3.24e-05	86	160	6	CID000004054
Drug	Phenoxybenzamine hydrochloride [63-92-3]; Down 200; 11.8uM; MCF7; HT_HG-U133A	DYNC2H1 DOCK9 ST14 ADCY9 SCAPER MACF1 ALG12 RBBP9	4.71e-05	183	160	8	5613_DN
Drug	AC1L1CLB	ANK2 GRK2 GRK3 PRKACA PRKACB GRIN3B	4.75e-05	92	160	6	CID000001951
Drug	AC1O5WLA	GRK2 GRK3 PRKACA PRKACB	5.58e-05	30	160	4	CID006442113
Drug	wortmannin from Penicillium funiculosum; Down 200; 0.01uM; HL60; HT_HG-U133A	TRAF2 ANK2 PPM1E ZNF236 ST14 CELSR3 RASGRP2 TRMT61A	6.61e-05	192	160	8	2703_DN
Drug	LY 171555	HDAC5 ADCY9 GRK2 GRK3 PRKACA PRKACB GRIN3B	6.67e-05	142	160	7	CID000001257
Drug	Terbutaline hemisulfate [23031-32-5]; Down 200; 7.2uM; PC3; HT_HG-U133A	TRAF2 HDAC5 ADCY9 GRK3 TIAM1 UTY ALG12 PML	6.86e-05	193	160	8	5764_DN
Drug	PDBu	ADCY9 GRK2 GRK3 CELSR3 RASGRP3 PRKACA PRKACB NMBR RASGRP2	6.96e-05	249	160	9	CID000037783
Drug	Azacyclonol [115-46-8]; Up 200; 15uM; MCF7; HT_HG-U133A	SHFL ASAP3 CUL7 KMT2D KLHL25 FZD10 UPK2 PML	7.11e-05	194	160	8	5398_UP
Drug	Delcorine; Down 200; 8.4uM; PC3; HT_HG-U133A	TRAF2 ATP9B ZNF236 ABCA7 PCNX2 GRK2 PRKACA PML	7.11e-05	194	160	8	4275_DN
Drug	Naringenine [480-41-1]; Up 200; 14.6uM; MCF7; HT_HG-U133A	KMT2B SHFL ATG2A DBN1 CUL7 ST14 NBEAL2 PRKACA	7.37e-05	195	160	8	3278_UP
Drug	Tocainide hydrochloride; Down 200; 17.4uM; MCF7; HT_HG-U133A	HSPG2 KMT2B SYNM ATG2A DBN1 NBEAL2 ALG12 PML	7.37e-05	195	160	8	7351_DN
Drug	Calycanthine [595-05-1]; Down 200; 11.6uM; MCF7; HT_HG-U133A	ADCY9 GRK2 GRK3 ACTL8 GFOD2 MFN2 ALG12 PML	7.64e-05	196	160	8	2764_DN
Drug	Telenzepine dihydrochloride [147416-96-4]; Down 200; 9uM; HL60; HT_HG-U133A	SHFL CD84 SLC22A14 SCAPER ZBTB10 MFN2 PML TRMT61A	7.64e-05	196	160	8	2388_DN
Drug	Vidarabine [5536-17-4]; Up 200; 15uM; HL60; HT_HG-U133A	RAPSN ANK2 DOCK9 PPARA SYNJ1 PRKACA ALG12 RASGRP2	7.64e-05	196	160	8	2706_UP
Drug	Dehydroisoandosterone 3-acetate [853-23-6]; Down 200; 12.2uM; PC3; HT_HG-U133A	HSPG2 TRAF2 DOCK9 ASAP3 PCNX2 NUP210 PML TRMT61A	7.64e-05	196	160	8	6673_DN
Drug	PNU-0251126 [267429-19-6]; Up 200; 10uM; PC3; HT_HG-U133A	TRAF2 DOCK9 ASAP3 PPARA CUL7 ABCA7 ALDH3A1 PML	7.92e-05	197	160	8	7388_UP
Drug	Phenelzine sulfate [156-51-4]; Down 200; 17uM; MCF7; HT_HG-U133A	HDAC5 CUL7 PCNX2 KLHL25 ACTL8 GFOD2 PRKACA PML	7.92e-05	197	160	8	3884_DN
Drug	Terbutaline hemisulfate [23031-32-5]; Down 200; 7.2uM; MCF7; HT_HG-U133A	SHFL DOCK9 ADCY9 GRK3 SLC22A14 SCAPER ALG12 PML	7.92e-05	197	160	8	3202_DN
Drug	DiC8	MGLL ADCY9 GRK2 GRK3 RASGRP3 PRKACA PRKACB	7.95e-05	146	160	7	CID000001323
Drug	Sulfapyridine [144-83-2]; Up 200; 16uM; PC3; HT_HG-U133A	HSPG2 ASAP3 ABCA7 ST14 NBEAL2 NUP210 PRKACA BRWD1	8.20e-05	198	160	8	7151_UP
Drug	Chlorambucil [305-03-3]; Down 200; 13.2uM; MCF7; HT_HG-U133A	HSPG2 TRAF2 HDAC5 DYNC2H1 GRB7 CUL7 PCNX2 UPK2	8.20e-05	198	160	8	3869_DN
Drug	Cefaclor [70356-03-5]; Up 200; 10.4uM; HL60; HT_HG-U133A	ADCY9 TBC1D16 SLC22A14 UPK2 SARDH HCRT RASGRP2 PML	8.49e-05	199	160	8	2483_UP
Drug	Yohimbinic acid monohydrate [27801-27-2]; Down 200; 11.2uM; HL60; HT_HG-U133A	HSPG2 TRAF2 DYNC2H1 CUL7 INTS5 RASGRP2 PML TRMT61A	8.49e-05	199	160	8	2147_DN
Drug	MDL-12330A	ADCY9 GRK2 GRK3 PRKACA PRKACB	1.02e-04	66	160	5	CID000004024
Drug	Tannins	GRK2 GRK3 PRKACA PRKACB	1.16e-04	36	160	4	CID000250395
Drug	HA1004	ADCY9 GRK2 GRK3 PRKACA PRKACB ALDH3A1	1.22e-04	109	160	6	CID000003546
Drug	Ro-1724	ADCY9 GRK2 GRK3 ACTL8 PRKACA PRKACB	1.29e-04	110	160	6	CID000005087
Drug	phenylisopropyladenosine	ADCY9 GRK2 GRK3 PRKACA PRKACB	1.35e-04	70	160	5	CID000005022
Disease	Kabuki syndrome (implicated_via_orthology)	KMT2D UTY	8.20e-05	3	155	2	DOID:0060473 (implicated_via_orthology)
Disease	depressive disorder (biomarker_via_orthology)	HDAC5 NDUFB7 PREP MFN2	1.63e-04	52	155	4	DOID:1596 (biomarker_via_orthology)
Disease	lumbar disc degeneration	DYNC2H1 PFKP CSMD1	4.23e-04	28	155	3	EFO_0004994
Disease	Parkinson's disease (biomarker_via_orthology)	DBN1 GRK2 GRK3	5.20e-04	30	155	3	DOID:14330 (biomarker_via_orthology)
Disease	Manic	HDAC5 SHANK3 GRK3 PREP	7.72e-04	78	155	4	C0338831
Disease	coronary aneurysm	CSMD2 GRIN3A CSMD1	8.22e-04	35	155	3	EFO_1000881
Disease	Osteitis Deformans	ZNF687 PML	9.63e-04	9	155	2	C0029401
Disease	response to lamotrigine	GRIN3A CSMD1	9.63e-04	9	155	2	EFO_0007661
Disease	level of Sphingomyelin (d34:2) in blood serum	RAPSN RIC1	2.06e-03	13	155	2	OBA_2045174
Disease	response to cisplatin, platinum measurement	ECT2 SARDH CSMD1	2.75e-03	53	155	3	EFO_0010154, GO_0072718
Disease	linoleic acid measurement	RAPSN ASAP3 MGLL THSD7B CERT1	3.08e-03	186	155	5	EFO_0006807
Disease	phosphatidylcholine 34:2 measurement	RAPSN TMEM178A	4.90e-03	20	155	2	EFO_0010376

Protein segments in the cluster

Peptide	Gene	Start	Entry
HSVGMAVLGQLARRL	PTRH1	46	Q86Y79
GMGEARRRATQLAHL	ACHE	271	P22303
FDRSMHKLQSGIGRL	ABLIM3	511	O94929
RGRTTFMSDHVARGK	BTNL10	96	A8MVZ5
LTMNEFSVHRIIGRG	GRK3	186	P35626
GVHRELGVRFSRMQS	ASAP3	466	Q8TDY4
EHGRGDFMSLAIIRR	EGFLAM	431	Q63HQ2
LLRFSCEMGHQLRGS	CSMD1	2941	Q96PZ7
VMRFSCEAGHVLRGS	CSMD2	2856	Q7Z408
LASAQRGISGGRIHM	CLPX	21	O76031
MAARTVIIDHGSGFL	ACTL8	1	Q9H568
RASSMLRHGLGAQRG	AEBP1	401	Q8IUX7
MAARTGHTALRRVVS	COQ10B	1	Q9H8M1
ISARHFQRVMGLIEG	ALDH3A1	286	P30838
HVMISRRGTYGALSV	ADGRV1	4906	Q8WXG9
SGHTVAVMGIDFTLR	CACHD1	801	Q5VU97
GLGVHLSFVRSVTMD	ARFGAP1	51	Q8N6T3
EGRTALIAAAYMGHR	ANKRD50	676	Q9ULJ7
DALLHRATMILTVGG	COX7A2P2	51	O60397
MGRVQLFEISLSHGR	ARRDC1	1	Q8N5I2
RGRRTTSMEVHFGQL	ATG2A	506	Q2TAZ0
FILGHDVRSSMAAIR	ABCA7	866	Q8IZY2
RRTHAPTVLALGFMA	ALG12	286	Q9BV10
LTMNDFSVHRIIGRG	GRK2	186	P25098
VLMGAGYRLLSRGHT	HSPG2	636	P98160
HMAVAYRLLGRLGSA	RAPSN	211	Q13702
NHFTSARMALIGLGV	UQCRC2	211	P22695
MALRTSGHLLLGVVR	RAD21	51	O60216
RHMIRFLKAIGSGES	RIC1	976	Q4ADV7
LRRALMTSHGSVEGR	ECT2	851	Q9H8V3
ILGSTIHTGFMLRLF	OR8G2P	166	Q6IF36
HTSVMALDRLFVIGG	KBTBD3	396	Q8NAB2
NIRGETALHMAARAG	ANK2	461	Q01484
SLRRHGSMVSLVSGA	CERT1	126	Q9Y5P4
IIGHSSGAIAAMRYA	RBBP9	71	O75884
VLGHRSIRMQGASRL	NUP210	321	Q8TEM1
RHSVGAVTGIMLLLF	MEGF11	846	A6BM72
GGEMFSHLRRIGRFS	PRKACA	126	P17612
GHMIVTLVARVLSFG	NMBR	301	P28336
FGTMTHLLENLRGSI	MATN4	551	O95460
VAGMGKTTLVRHFVR	NLRC3	146	Q7RTR2
RSSSVLGGRMGFVHN	RASGRP2	486	Q7LDG7
HSMGGAIAILTAAER	MGLL	121	Q99685
VHLGRRVVMNSREFG	LGALS16	56	A8MUM7
TRGLRATVMRGHCHA	FLYWCH1	161	Q4VC44
KRSAALGQFVMHRGL	ATP9B	926	O43861
TLRTLATGHLGFMIT	FREM2	1666	Q5SZK8
TSMRIGDEGRLAVHF	FREM2	2731	Q5SZK8
SHGLEIVMLSFHGRR	FBXO31	311	Q5XUX0
IVMLSFHGRRARGTK	FBXO31	316	Q5XUX0
IFAGFRTRSQMLLGH	KIF27	616	Q86VH2
LGRRALGTAAHNMAI	PCNX2	1636	A6NKB5
VLGRRALGTASHSMS	PCNX3	1586	Q9H6A9
IHMGSGEGRRKAFTT	OR2M3	226	Q8NG83
IHMGSGEGRRKAFTT	OR2M5	226	A3KFT3
IHMGSGEGRRKAFTT	OR2M7	226	Q8NG81
ETLTRGFTLMGLFTH	OR2T6	6	Q8NHC8
GALQSSRTFLRHRVM	PDPR	421	Q8NCN5
SAVRVGIADGHRMLA	PFKP	431	Q01813
AGSHYITLHMRRGIL	CUL7	871	Q14999
MRSVVGFLSQRGLHG	DCAF5	11	Q96JK2
QGRVLVHCAMGVSRS	DUSP13	131	Q9UII6
RMLETAHRFAGTSAG	PNPLA1	41	Q8N8W4
LRHLSFSGMSGARLL	KMT2B	2451	Q9UMN6
MAGVSFSGHRLELLA	DBN1	1	Q16643
VSDRLRYSAIMHGGL	OR2F2	126	O95006
AGAVIHMRSVEGSRR	OR5C1	226	Q8NGR4
TLVAMDFSGHAGRVI	GRB7	371	Q14451
MGAHLVRRYLGDASV	NDUFB7	1	P17568
ISGMRLSVDNAFRHG	MACF1	2516	Q9UPN3
VLARRHMKVAFFGRT	MFN2	91	O95140
LVGDLLRGTAHMAVT	GRIN3A	616	Q8TCU5
TGVVTFIRGNMLHVA	PPM1E	331	Q8WY54
EVFGTGAMRHVVILF	GIMAP5	136	Q96F15
VSRLIFVRHMGGILA	PREP	486	P48147
FVRHMGGILAVANIR	PREP	491	P48147
GFVALFHIRRVMKTG	FZD10	416	Q9ULW2
QIVASMSAGGRLGRH	DYNC2H1	2401	Q8NCM8
GGEMFSHLRRIGRFS	PRKACB	126	P22694
LFVFGGTSIHRDMVS	KLHL25	446	Q9H0H3
VMHSGRRLLGTYFRV	DOCK9	1771	Q9BZ29
AFVHEVMVVGSAGRL	GFOD2	246	Q3B7J2
HSFMRRGGLEVALQV	GIMD1	56	P0DJR0
HTGTVLCGILGMRRF	ADCY9	491	O60503
SRIMLSAGHDGSIFI	BRWD1	481	Q9NSI6
VLLMVRRGHVGIFFI	MS4A15	91	Q8N5U1
LVSTACGFRLHRGMN	LAMTOR4	46	Q0VGL1
VHSALGRMTVVRQIF	GRID1	271	Q9ULK0
LHRILSGIMSGRDTI	SLC44A3	201	Q8N4M1
TLLFMSGIHVSGRGF	DCBLD2	166	Q96PD2
LHRVREALALMGFTT	DCST2	316	Q5T1A1
RCFGHLTRQLMTLAG	HDAC5	981	Q9UQL6
GRRGHHVLMVSLDFS	CELSR3	1861	Q9NYQ7
TLVRHGARLVNMAGL	ERVFC1	231	P60507
FTLSLRMRELGVSVH	SLC22A14	396	Q9Y267
SIVGAEGLSLAFRHM	SCAPER	1236	Q9BY12
LFREMGAGRQHRVTL	KIFC2	511	Q96AC6
GTLMTHGSYRVRISV	LRRC4B	401	Q9NT99
CLSVGMSHNAIRFGR	PPARA	161	Q07869
ASGNHAAGILTMGRR	HCRT	86	O43612
ATVLSNRFGHRLVVM	SLC16A6	81	O15403
GMALTLGLAATRHLD	MROH5	326	Q6ZUA9
LVGDLLAGRAHMAVT	GRIN3B	516	O60391
LGILGSTIHTSFMLR	OR8G3P	151	P0DMU2
DHMYSARVGTVLGQR	RPUSD3	261	Q6P087
LGGMDSRLFGFVRLH	UTY	46	O14607
RAHGNSGMVRAKFRS	RPL35A	76	P18077
RAFLLNGSIDGIRHM	SLC6A15	271	Q9H2J7
MARFALTVVRHGETR	TIGAR	1	Q9NQ88
SLTMHFRARATGPAA	SYNM	161	O15061
GLQVGSHRVRMSRGF	SYNJ1	261	O43426
RGGRHLGSVSTAMAA	TMEM191B	36	P0C7N4
RGGRHLGSVSTAMAA	TMEM191C	36	A6NGB0
IGAEMALRTFGHLLR	PSMD2	666	Q13200
LHLRRITAGFLGMAV	TMEM178A	171	Q8NBL3
MHAAVGQLGRARAET	PML	261	P29590
LMAVVGGLSHSSISR	RASGRP3	241	Q8IV61
GEGTSLLTMRRSFHG	LAMA1	2631	P25391
RHAGAVIRTLSGMAR	NBEAL2	556	Q6ZNJ1
ALVTMGTGTFGRVHL	PRKY	51	O43930
SRVGRFRSMIVHSEG	PRSS47P	246	A8MTI9
AMGFRTHHTGLLSVL	CD84	216	Q9UIB8
HQRGRTLTMVSLGCG	MPV17	46	P39210
RELLRMFHDSLAGGS	INTS5	311	Q6P9B9
SDHGSRRVGMLAVLL	SLC25A38	61	Q96DW6
RAAGHLVRAMRLSFV	SARDH	716	Q9UL12
RLRGCIGTFSAMNLH	AMMECR1	171	Q9Y4X0
MASTSRDVIAGRGIH	PGBD2	1	Q6P3X8
DVALTVHRAFRMIGL	TMEM237	216	Q96Q45
STKFSLFAGGMLRVH	TMED9	126	Q9BVK6
LMRKFGSDHTGVGRS	SHFL	31	Q9NUL5
TGRGTHLSLFFVVMK	TRAF2	401	Q12933
VHGGTTADMIYSRVR	RNF213	2451	Q63HN8
FTTRLGHSIGRMFAS	RPF1	251	Q9H9Y2
MISFHVIFLSLGRGK	nan	1	Q6ZQY7
MGRIFLDHIGGTRLF	YPEL5	1	P62699
GKAFTRSTGLILHMR	ZNF846	316	Q147U1
GKSFSRGSILVMHQR	ZSCAN2	536	Q7Z7L9
MGRLGIFSVSSFHAL	TIAM1	651	Q13009
AVGMASLGRVLHRRI	TRPM5	136	Q9NZQ8
LLHTLERMGRSRGVA	ACAT2	366	Q9BWD1
ARVFSHIRLGMGHVL	SLC35A5	221	Q9BS91
DFVELGVTRVGHRMN	SHANK3	1706	Q9BYB0
HTVRLAMGNGLRADV	SLC27A5	401	Q9Y2P5
LDMFGISTRHIIAAV	TKTL2	606	Q9H0I9
FGLHARGVELMRFTT	ST14	216	Q9Y5Y6
CGVFRVDLGHMRSLR	TBC1D16	296	Q8TBP0
RSAAAGLLGALHLVM	TMEM131	36	Q92545
AILSLGHGAMVAVRV	TRMT61A	16	Q96FX7
HVRRIGSRMVLSVFS	VPS13C	2756	Q709C8
MIFRGGLSHALRKQA	TBC1D15	341	Q8TC07
PSGHATRAALMSRFI	PLPP6	211	Q8IY26
LGLSRVMLGRHNVTD	PLPP6	246	Q8IY26
CHLTGGNATLMVRRA	UPK2	51	O00526
GLRHMIGGFSLHQRI	ZNF445	436	P59923
MQARTLFKESRRGHG	UBN1	566	Q9NPG3
AFTTGGSLRRHMGIH	ZNF236	721	Q9UL36
THGMAFIRARQGAVG	ZNF687	1221	Q8N1G0
GTRFERLLMRIGHQS	PSMD5	336	Q16401
AIFRSMGRLAHIRTE	SEMA3E	201	O15041
IFMLAASVGIRHGSR	ZBTB10	786	Q96DT7
RIDSHRRTMAVFAVG	TMEM207	81	Q6UWW9
FRSRSRNVKHMAIGG	THSD7B	361	Q9C0I4
TGSRQGIEMHLFRVE	SNTB2	406	Q13425
PRMSQLFHRTIGSGA	TRIP12	421	Q14669
GKVFSGVSSLRMHIR	ZNF891	466	A8MT65
RVFMSAASVGIRHGS	ZBTB46	481	Q86UZ6
MRLSVAAAISHGRVF	MRPL17	1	Q9NRX2
AAAISHGRVFRRMGL	MRPL17	6	Q9NRX2
TGEGRLLRFRMGHSA	WDR36	366	Q8NI36
MESNSFHRGGVARLL	ZAN	91	Q9Y493
IGGFMVRQRKSHTRT	KMT2D	1696	O14686
RGERLHMFRVGGLVF	KMT2D	5171	O14686
GISESHQMGIFRILA	MYO5A	316	Q9Y4I1