Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	chloride:monoatomic cation symporter activity	SLC6A11 SLC12A1 SLC12A3 SLC12A4	1.60e-07	23	43	4	GO:0015377
GeneOntologyMolecularFunction	monoatomic anion:monoatomic cation symporter activity	SLC6A11 SLC12A1 SLC12A3 SLC12A4	2.69e-07	26	43	4	GO:0015296
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	OTOP2 SLC6A11 GRIN1 ATP6V0A1 TMCO3 SLC12A1 SLC12A3 SLC12A4 MRS2 SLC47A2	6.52e-07	627	43	10	GO:0022890
GeneOntologyMolecularFunction	potassium:chloride symporter activity	SLC12A1 SLC12A3 SLC12A4	7.74e-07	9	43	3	GO:0015379
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	OTOP2 SLC6A11 GRIN1 ATP6V0A1 TMCO3 SLC12A1 SLC12A3 SLC12A4 MRS2 SLC47A2	1.10e-06	664	43	10	GO:0008324
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC6A11 TMCO3 SLC12A1 SLC12A3 SLC12A4 SLC47A2 SLC22A5	2.99e-06	296	43	7	GO:0015291
GeneOntologyMolecularFunction	active monoatomic ion transmembrane transporter activity	SLC6A11 ATP6V0A1 TMCO3 SLC12A1 SLC12A3 SLC12A4 SLC47A2	3.34e-06	301	43	7	GO:0022853
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	OTOP2 SLC6A11 GRIN1 ATP6V0A1 TMCO3 SLC12A1 SLC12A3 SLC12A4 MRS2 SLC47A2	3.60e-06	758	43	10	GO:0015318
GeneOntologyMolecularFunction	transmembrane transporter activity	OTOP2 SLC6A11 GRIN1 ATP6V0A1 TMCO3 SLC12A1 SLC12A3 SLC12A4 MRS2 SLC47A2 SLC2A11 SLC22A5	4.76e-06	1180	43	12	GO:0022857
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	OTOP2 SLC6A11 GRIN1 ATP6V0A1 TMCO3 SLC12A1 SLC12A3 SLC12A4 MRS2 SLC47A2	5.37e-06	793	43	10	GO:0015075
GeneOntologyMolecularFunction	sodium:chloride symporter activity	SLC6A11 SLC12A1 SLC12A3	6.19e-06	17	43	3	GO:0015378
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC6A11 ATP6V0A1 TMCO3 SLC12A1 SLC12A3 SLC12A4 SLC47A2 SLC22A5	6.95e-06	477	43	8	GO:0022804
GeneOntologyMolecularFunction	monoatomic anion:sodium symporter activity	SLC6A11 SLC12A1 SLC12A3	8.80e-06	19	43	3	GO:0015373
GeneOntologyMolecularFunction	transporter activity	OTOP2 SLC6A11 GRIN1 ATP6V0A1 TMCO3 SLC12A1 SLC12A3 SLC12A4 MRS2 SLC47A2 SLC2A11 SLC22A5	1.17e-05	1289	43	12	GO:0005215
GeneOntologyMolecularFunction	potassium:sodium symporter activity	SLC12A1 SLC12A3	1.36e-05	3	43	2	GO:0009674
GeneOntologyMolecularFunction	sodium:potassium:chloride symporter activity	SLC12A1 SLC12A3	1.36e-05	3	43	2	GO:0008511
GeneOntologyMolecularFunction	symporter activity	SLC6A11 SLC12A1 SLC12A3 SLC12A4 SLC22A5	1.71e-05	150	43	5	GO:0015293
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	SLC6A11 GRIN1 TMCO3 SLC12A1 SLC12A3 SLC12A4 MRS2	5.54e-05	465	43	7	GO:0046873
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR4C46 CCR4 OR2Z1 PTGER1 GPR34 OR10P1 OR5AN1 OR9A2 OR10D4P	9.10e-05	884	43	9	GO:0004930
GeneOntologyMolecularFunction	solute:monoatomic cation symporter activity	SLC6A11 SLC12A1 SLC12A3 SLC12A4	1.24e-04	119	43	4	GO:0015294
GeneOntologyMolecularFunction	chloride transmembrane transporter activity	SLC6A11 SLC12A1 SLC12A3 SLC12A4	1.50e-04	125	43	4	GO:0015108
GeneOntologyMolecularFunction	olfactory receptor activity	OR4C46 OR2Z1 OR10P1 OR5AN1 OR9A2 OR10D4P	3.03e-04	431	43	6	GO:0004984
GeneOntologyMolecularFunction	monoatomic anion transmembrane transporter activity	SLC6A11 SLC12A1 SLC12A3 SLC12A4	3.08e-04	151	43	4	GO:0008509
GeneOntologyMolecularFunction	potassium ion transmembrane transporter activity	TMCO3 SLC12A1 SLC12A3 SLC12A4	4.52e-04	167	43	4	GO:0015079
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR4C46 CCR4 GRIN1 OR2Z1 PTGER1 GPR34 OR10P1 OR5AN1 OR9A2 OR10D4P	4.81e-04	1353	43	10	GO:0004888
GeneOntologyMolecularFunction	inorganic anion transmembrane transporter activity	SLC6A11 SLC12A1 SLC12A3 SLC12A4	4.94e-04	171	43	4	GO:0015103
GeneOntologyMolecularFunction	proton transmembrane transporter activity	OTOP2 ATP6V0A1 TMCO3 SLC47A2	7.05e-04	188	43	4	GO:0015078
GeneOntologyMolecularFunction	glutamate receptor binding	GRIN1 CANX PRNP	7.06e-04	81	43	3	GO:0035254
GeneOntologyMolecularFunction	solute:sodium symporter activity	SLC6A11 SLC12A1 SLC12A3	7.06e-04	81	43	3	GO:0015370
GeneOntologyMolecularFunction	xenobiotic transmembrane transporter activity	SLC47A2 SLC22A5	2.43e-03	34	43	2	GO:0042910
GeneOntologyMolecularFunction	ionotropic glutamate receptor binding	GRIN1 CANX	5.61e-03	52	43	2	GO:0035255
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SLC6A11 SLC12A1 SLC12A3	5.92e-03	171	43	3	GO:0015081
GeneOntologyBiologicalProcess	monoatomic cation transmembrane transport	OTOP2 SLC6A11 GRIN1 ATP6V0A1 TMCO3 SLC12A1 SLC12A3 SLC12A4 PIRT MRS2 SLC47A2 PRNP	3.17e-07	942	43	12	GO:0098655
GeneOntologyBiologicalProcess	monoatomic cation transport	OTOP2 SLC6A11 GRIN1 ATP6V0A1 TMCO3 SLC12A1 SLC12A3 SLC12A4 PIRT MRS2 SLC47A2 PRNP SLC22A5	3.84e-07	1157	43	13	GO:0006812
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	OTOP2 SLC6A11 GRIN1 ATP6V0A1 TMCO3 SLC12A1 SLC12A3 SLC12A4 PIRT MRS2 SLC47A2 PRNP	1.89e-06	1115	43	12	GO:0034220
GeneOntologyBiologicalProcess	inorganic cation transmembrane transport	OTOP2 SLC6A11 GRIN1 ATP6V0A1 TMCO3 SLC12A1 SLC12A3 SLC12A4 MRS2 SLC47A2 PRNP	2.07e-06	922	43	11	GO:0098662
GeneOntologyBiologicalProcess	monoatomic ion transport	OTOP2 SLC6A11 GRIN1 ATP6V0A1 TMCO3 SLC12A1 SLC12A3 SLC12A4 PIRT MRS2 SLC47A2 PRNP SLC22A5	2.67e-06	1374	43	13	GO:0006811
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	OTOP2 SLC6A11 GRIN1 ATP6V0A1 TMCO3 SLC12A1 SLC12A3 SLC12A4 MRS2 SLC47A2 PRNP	5.33e-06	1017	43	11	GO:0098660
GeneOntologyBiologicalProcess	chloride ion homeostasis	SLC12A1 SLC12A3 SLC12A4	1.88e-05	25	43	3	GO:0055064
GeneOntologyBiologicalProcess	monoatomic anion homeostasis	SLC12A1 SLC12A3 SLC12A4	2.67e-05	28	43	3	GO:0055081
GeneOntologyBiologicalProcess	sensory perception	OR4C46 KERA GRIN1 OR2Z1 PKHD1L1 OR10P1 PDYN OR5AN1 OR9A2 OR10D4P	5.50e-05	1072	43	10	GO:0007600
GeneOntologyBiologicalProcess	potassium ion homeostasis	SLC12A1 SLC12A3 SLC12A4	6.24e-05	37	43	3	GO:0055075
GeneOntologyBiologicalProcess	cell volume homeostasis	SLC12A1 SLC12A3 SLC12A4	9.15e-05	42	43	3	GO:0006884
GeneOntologyBiologicalProcess	potassium ion transmembrane transport	TMCO3 SLC12A1 SLC12A3 SLC12A4 PRNP	1.17e-04	232	43	5	GO:0071805
GeneOntologyBiologicalProcess	potassium ion import across plasma membrane	SLC12A1 SLC12A3 SLC12A4	1.64e-04	51	43	3	GO:1990573
GeneOntologyBiologicalProcess	metal ion transport	SLC6A11 GRIN1 TMCO3 SLC12A1 SLC12A3 SLC12A4 MRS2 PRNP SLC22A5	1.81e-04	1000	43	9	GO:0030001
GeneOntologyBiologicalProcess	inorganic ion import across plasma membrane	SLC12A1 SLC12A3 SLC12A4 PRNP	2.16e-04	142	43	4	GO:0099587
GeneOntologyBiologicalProcess	inorganic cation import across plasma membrane	SLC12A1 SLC12A3 SLC12A4 PRNP	2.16e-04	142	43	4	GO:0098659
GeneOntologyBiologicalProcess	potassium ion transport	TMCO3 SLC12A1 SLC12A3 SLC12A4 PRNP	2.46e-04	272	43	5	GO:0006813
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR4C46 OR2Z1 OR10P1 OR5AN1 OR9A2 OR10D4P	2.58e-04	432	43	6	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of smell	OR4C46 OR2Z1 OR10P1 OR5AN1 OR9A2 OR10D4P	3.82e-04	465	43	6	GO:0007608
GeneOntologyBiologicalProcess	proton transmembrane transport	OTOP2 ATP6V0A1 TMCO3 SLC47A2	4.28e-04	170	43	4	GO:1902600
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR4C46 CCR4 OR2Z1 PTGER1 GPR34 OR10P1 PDYN OR5AN1 OR9A2 OR10D4P	4.75e-04	1395	43	10	GO:0007186
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR4C46 OR2Z1 OR10P1 OR5AN1 OR9A2 OR10D4P	4.78e-04	485	43	6	GO:0050907
GeneOntologyBiologicalProcess	regulation of dendritic spine maintenance	GRIN1 PRNP	6.36e-04	18	43	2	GO:1902950
GeneOntologyBiologicalProcess	detection of stimulus	OR4C46 NOX3 OR2Z1 OR10P1 OR5AN1 OR9A2 OR10D4P	6.72e-04	722	43	7	GO:0051606
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR4C46 OR2Z1 OR10P1 OR5AN1 OR9A2 OR10D4P	7.17e-04	524	43	6	GO:0009593
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR4C46 OR2Z1 OR10P1 OR5AN1 OR9A2 OR10D4P	8.96e-04	547	43	6	GO:0007606
GeneOntologyBiologicalProcess	positive regulation of cytosolic calcium ion concentration	CCR4 GRIN1 PRKG1 PTGER1	1.20e-03	224	43	4	GO:0007204
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR4C46 OR2Z1 OR10P1 OR5AN1 OR9A2 OR10D4P	1.23e-03	582	43	6	GO:0050906
GeneOntologyBiologicalProcess	import across plasma membrane	SLC12A1 SLC12A3 SLC12A4 PRNP	1.32e-03	230	43	4	GO:0098739
HumanPheno	Low-to-normal blood pressure	SLC12A1 SLC12A3	2.54e-05	4	11	2	HP:0002632
HumanPheno	Renal potassium wasting	SLC12A1 SLC12A3	6.33e-05	6	11	2	HP:0000128
MousePheno	abnormal body temperature homeostasis	OMA1 NOX3 PTGER1 PRNP	5.49e-06	50	33	4	MP:0001777
MousePheno	abnormal fat cell mitochondrial morphology	OMA1 PRKG1	3.23e-05	4	33	2	MP:0014398
MousePheno	decreased urine sodium level	SLC12A1 SLC12A3 PTGER1	4.20e-05	29	33	3	MP:0006317
Domain	SLC12A_fam	SLC12A1 SLC12A3 SLC12A4	3.17e-07	7	40	3	IPR004842
Domain	SLC12	SLC12A1 SLC12A3 SLC12A4	5.06e-07	8	40	3	PF03522
Domain	SLC12_C	SLC12A1 SLC12A3 SLC12A4	5.06e-07	8	40	3	IPR018491
Domain	AA_permease_N	SLC12A1 SLC12A3	1.34e-05	3	40	2	IPR013612
Domain	AA_permease_N	SLC12A1 SLC12A3	1.34e-05	3	40	2	PF08403
Domain	AA-permease/SLC12A_dom	SLC12A1 SLC12A3 SLC12A4	1.36e-05	22	40	3	IPR004841
Domain	AA_permease	SLC12A1 SLC12A3 SLC12A4	1.36e-05	22	40	3	PF00324
Domain	GPCR_Rhodpsn_7TM	OR4C46 CCR4 OR2Z1 PTGER1 GPR34 OR10P1 OR5AN1 OR9A2	7.31e-05	670	40	8	IPR017452
Domain	7tm_1	OR4C46 CCR4 OR2Z1 PTGER1 GPR34 OR10P1 OR5AN1 OR9A2	7.86e-05	677	40	8	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR4C46 CCR4 OR2Z1 PTGER1 GPR34 OR10P1 OR5AN1 OR9A2	8.54e-05	685	40	8	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR4C46 CCR4 OR2Z1 PTGER1 GPR34 OR10P1 OR5AN1 OR9A2	9.07e-05	691	40	8	PS50262
Domain	GPCR_Rhodpsn	OR4C46 CCR4 OR2Z1 PTGER1 GPR34 OR10P1 OR5AN1 OR9A2	9.16e-05	692	40	8	IPR000276
Domain	SUGAR_TRANSPORT_1	SLC2A11 SLC22A5	1.20e-03	24	40	2	PS00216
Domain	Olfact_rcpt	OR4C46 OR2Z1 OR10P1 OR5AN1 OR9A2	1.44e-03	393	40	5	IPR000725
Domain	Sugar_transporter_CS	SLC2A11 SLC22A5	2.13e-03	32	40	2	IPR005829
Domain	Sugar_tr	SLC2A11 SLC22A5	2.69e-03	36	40	2	PF00083
Domain	MFS_sugar_transport-like	SLC2A11 SLC22A5	2.69e-03	36	40	2	IPR005828
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	SLC6A11 LMF1 ATP6V0A1 SLC12A1 SLC12A3 SLC12A4 DERL1 MRS2 SLC47A2 SLC2A11 SOAT2 SLC22A5	7.11e-08	736	34	12	M27287
Pathway	REACTOME_CATION_COUPLED_CHLORIDE_COTRANSPORTERS	SLC12A1 SLC12A3 SLC12A4	4.46e-07	7	34	3	M27339
Pathway	REACTOME_CATION_COUPLED_CHLORIDE_COTRANSPORTERS	SLC12A1 SLC12A3 SLC12A4	4.46e-07	7	34	3	MM15081
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	SLC6A11 SLC12A1 SLC12A3 SLC12A4 SLC47A2 SLC2A11 SLC22A5	1.77e-06	249	34	7	M5988
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	SLC6A11 LMF1 ATP6V0A1 SLC12A1 SLC12A3 SLC12A4 DERL1 MRS2 SOAT2 SLC22A5	2.96e-06	681	34	10	MM14985
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PDYN_TO_TRANSPORT_OF_CALCIUM	GRIN1 PDYN	8.42e-05	6	34	2	M47668
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	SLC6A11 SLC12A1 SLC12A3 SLC12A4 SLC22A5	2.45e-04	238	34	5	MM15076
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR4C46 PRKG1 OR2Z1 OR10P1 OR5AN1 OR9A2	2.97e-04	389	34	6	M14091
Pathway	REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE	DERL1 CANX	5.81e-04	15	34	2	MM15175
Pathway	REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS	SLC12A1 SLC12A3 DERL1 SLC22A5	8.30e-04	177	34	4	M27476
Pathway	KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_TRANSPORT_OF_CALCIUM	GRIN1 PRNP	8.43e-04	18	34	2	M47761
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	CCR4 PTGER1 GPR34 OR10D4P	9.99e-04	186	34	4	MM15994
Pathway	REACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS	SLC6A11 SLC47A2 SLC22A5	1.07e-03	84	34	3	M27334
Pathway	REACTOME_SLC_TRANSPORTER_DISORDERS	SLC12A1 SLC12A3 SLC22A5	1.72e-03	99	34	3	M27474
Pubmed	Similar effects of all WNK3 variants on SLC12 cotransporters.	SLC12A1 SLC12A3 SLC12A4	1.05e-07	8	44	3	21613606
Pubmed	Cation-chloride cotransporters and neuronal function.	SLC12A1 SLC12A3 SLC12A4	1.58e-07	9	44	3	19323993
Pubmed	Urinary exosomes in the diagnosis of Gitelman and Bartter syndromes.	SLC12A1 SLC12A3	1.56e-06	2	44	2	25422309
Pubmed	From Fish Physiology to Human Disease: The Discovery of the NCC, NKCC2, and the Cation-Coupled Chloride Cotransporters.	SLC12A1 SLC12A3	1.56e-06	2	44	2	37968800
Pubmed	Calnexin inhibits thermal aggregation and neurotoxicity of prion protein.	CANX PRNP	1.56e-06	2	44	2	20506117
Pubmed	Molecular cloning, primary structure, and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney.	SLC12A1 SLC12A3	1.56e-06	2	44	2	8021284
Pubmed	Rare independent mutations in renal salt handling genes contribute to blood pressure variation.	SLC12A1 SLC12A3 SLC12A4	2.86e-06	22	44	3	18391953
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR4C46 OR2Z1 OR10P1 OR5AN1 OR9A2 OR10D4P	4.31e-06	340	44	6	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR4C46 OR2Z1 OR10P1 OR5AN1 OR9A2 OR10D4P	4.31e-06	340	44	6	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR4C46 OR2Z1 OR10P1 OR5AN1 OR9A2 OR10D4P	4.53e-06	343	44	6	32295537
Pubmed	Effect of gestational ethanol exposure on the NMDA receptor complex in rat forebrain: from gene transcription to cell surface.	GRIN1 CANX	4.69e-06	3	44	2	11506858
Pubmed	Contributions of rare coding variants in hypotension syndrome genes to population blood pressure variation.	SLC12A1 SLC12A3	4.69e-06	3	44	2	30113482
Pubmed	Downregulation of NCC and NKCC2 cotransporters by kidney-specific WNK1 revealed by gene disruption and transgenic mouse models.	SLC12A1 SLC12A3	4.69e-06	3	44	2	21131289
Pubmed	Cardiovascular expression of the mouse WNK1 gene during development and adulthood revealed by a BAC reporter assay.	SLC12A1 SLC12A3	4.69e-06	3	44	2	16816365
Pubmed	Non-association of the thiazide-sensitive Na,Cl-cotransporter gene with polygenic hypertension in both rats and humans.	SLC12A1 SLC12A3	4.69e-06	3	44	2	11564973
Pubmed	Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family.	SLC12A1 SLC12A4	4.69e-06	3	44	2	8663127
Pubmed	OS9 Protein Interacts with Na-K-2Cl Co-transporter (NKCC2) and Targets Its Immature Form for the Endoplasmic Reticulum-associated Degradation Pathway.	SLC12A1 SLC12A3	4.69e-06	3	44	2	26721884
Pubmed	POLR2F, ATP6V0A1 and PRNP expression in colorectal cancer: new molecules with prognostic significance?	ATP6V0A1 PRNP	4.69e-06	3	44	2	18505059
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR4C46 OR2Z1 OR10P1 OR5AN1 OR9A2 OR10D4P	4.77e-06	346	44	6	14611657
Pubmed	Discovery of three novel orphan G-protein-coupled receptors.	CCR4 GPR34	9.37e-06	4	44	2	10036181
Pubmed	H+-ATPase B1 subunit localizes to thick ascending limb and distal convoluted tubule of rodent and human kidney.	SLC12A1 SLC12A3	9.37e-06	4	44	2	29993276
Pubmed	Impaired phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome.	SLC12A1 SLC12A3	9.37e-06	4	44	2	21972418
Pubmed	Appropriate NR1-NR1 disulfide-linked homodimer formation is requisite for efficient expression of functional, cell surface N-methyl-D-aspartate NR1/NR2 receptors.	GRIN1 CANX	9.37e-06	4	44	2	14732708
Pubmed	DNA analysis of renal electrolyte transporter genes among patients suffering from Bartter and Gitelman syndromes: summary of mutation screening.	SLC12A1 SLC12A3	9.37e-06	4	44	2	21631963
Pubmed	Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity.	GRIN1 PRNP	1.56e-05	5	44	2	26589795
Pubmed	In vivo identification of eugenol-responsive and muscone-responsive mouse odorant receptors.	OR5AN1 OR10D4P	1.56e-05	5	44	2	25411495
Pubmed	Characterization of erasin (UBXD2): a new ER protein that promotes ER-associated protein degradation.	DERL1 CANX	1.56e-05	5	44	2	16968747
Pubmed	EDEM1 reveals a quality control vesicular transport pathway out of the endoplasmic reticulum not involving the COPII exit sites.	DERL1 CANX	1.56e-05	5	44	2	17360537
Pubmed	Genetic variation in the renal sodium transporters NKCC2, NCC, and ENaC in relation to the effects of loop diuretic drugs.	SLC12A1 SLC12A3	1.56e-05	5	44	2	17460608
Pubmed	A SPAK isoform switch modulates renal salt transport and blood pressure.	SLC12A1 SLC12A3	1.56e-05	5	44	2	21907141
Pubmed	Both raft- and non-raft proteins associate with CHAPS-insoluble complexes: some APP in large complexes.	CANX PRNP	2.34e-05	6	44	2	12927782
Pubmed	WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis.	SLC12A1 SLC12A3	2.34e-05	6	44	2	16275913
Pubmed	Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways.	SLC12A1 SLC12A3	2.34e-05	6	44	2	21321328
Pubmed	Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium.	SLC12A1 SLC12A3	2.34e-05	6	44	2	15550389
Pubmed	Lateral septum as a melanocortin downstream site in obesity development.	GRIN1 PDYN	2.34e-05	6	44	2	37171957
Pubmed	A shared endoplasmic reticulum-associated degradation pathway involving the EDEM1 protein for glycosylated and nonglycosylated proteins.	DERL1 CANX	3.27e-05	7	44	2	23233672
Pubmed	Impairment in renal medulla development underlies salt wasting in Clc-k2 channel deficiency.	SLC12A1 SLC12A3	3.27e-05	7	44	2	34499620
Pubmed	Intrarenal and cellular localization of CLC-K2 protein in the mouse kidney.	SLC12A1 SLC12A3	3.27e-05	7	44	2	11423561
Pubmed	Sox9 Activation Highlights a Cellular Pathway of Renal Repair in the Acutely Injured Mammalian Kidney.	SLC12A1 SLC12A3	4.36e-05	8	44	2	26279573
Pubmed	Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1).	SLC12A1 SLC12A4	4.36e-05	8	44	2	12386165
Pubmed	Protein Binder Toolbox for Studies of Solute Carrier Transporters.	ATP6V0A1 SLC12A4 CANX	5.00e-05	56	44	3	38878854
Pubmed	Hnf4a deletion in the mouse kidney phenocopies Fanconi renotubular syndrome.	SLC12A1 SLC12A3	6.99e-05	10	44	2	30046000
Pubmed	The mahogany protein is a receptor involved in suppression of obesity.	PDYN PRNP	6.99e-05	10	44	2	10086355
Pubmed	Notch signaling promotes nephrogenesis by downregulating Six2.	SLC12A1 SLC12A3	1.02e-04	12	44	2	27633993
Pubmed	Genetic dissection of sodium and potassium transport along the aldosterone-sensitive distal nephron: importance in the control of blood pressure and hypertension.	SLC12A1 SLC12A3	1.02e-04	12	44	2	23684652
Pubmed	Identification of SVIP as an endogenous inhibitor of endoplasmic reticulum-associated degradation.	DERL1 CANX	1.02e-04	12	44	2	17872946
Pubmed	Odorant and vomeronasal receptor genes in two mouse genome assemblies.	OR2Z1 OR5AN1 OR10D4P	1.15e-04	74	44	3	15081110
Pubmed	Pax2 and pax8 regulate branching morphogenesis and nephron differentiation in the developing kidney.	SLC12A1 SLC12A3	1.21e-04	13	44	2	17314325
Pubmed	Long-term expandable mouse and human-induced nephron progenitor cells enable kidney organoid maturation and modeling of plasticity and disease.	SLC12A1 SLC12A3	1.21e-04	13	44	2	38692273
Pubmed	Reduced Abd-B Hox function during kidney development results in lineage infidelity.	SLC12A1 SLC12A3	1.41e-04	14	44	2	29596840
Pubmed	Hoxd11 specifies a program of metanephric kidney development within the intermediate mesoderm of the mouse embryo.	SLC12A1 SLC12A3	1.41e-04	14	44	2	18485340
Pubmed	Intact prostaglandin signaling through EP2 and EP4 receptors in stromal progenitor cells is required for normal development of the renal cortex in mice.	SLC12A1 PTGER1	1.41e-04	14	44	2	35037469
Pubmed	β-catenin regulates the formation of multiple nephron segments in the mouse kidney.	SLC12A1 SLC12A3	1.63e-04	15	44	2	31685872
Pubmed	The transcription factor grainyhead-like 2 regulates the molecular composition of the epithelial apical junctional complex.	SLC12A1 SLC12A3	1.86e-04	16	44	2	20978075
Pubmed	Bmp7 drives proximal tubule expansion and determines nephron number in the developing kidney.	SLC12A1 SLC12A3	1.86e-04	16	44	2	35877077
Pubmed	Conserved and Divergent Features of Human and Mouse Kidney Organogenesis.	SLC12A1 SLC12A3	2.10e-04	17	44	2	29449453
Pubmed	Comprehensive analysis of low-abundance proteins in human urinary exosomes using peptide ligand library technology, peptide OFFGEL fractionation and nanoHPLC-chip-MS/MS.	SLC12A1 SLC12A3	2.10e-04	17	44	2	21082674
Pubmed	Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.	ELOVL3 GRIN1 ATP6V0A1 MRS2 PKHD1L1 SOAT2	2.15e-04	686	44	6	29987050
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	CCR4 GRIN1 ATP6V0A1 TMCO3 CANX PRNP	2.34e-04	697	44	6	28298427
Pubmed	Mutations in the leukemia inhibitory factor receptor (LIFR) gene and Lifr deficiency cause urinary tract malformations.	SLC12A1 SLC12A3	2.36e-04	18	44	2	28334964
Pubmed	Notch is required for the formation of all nephron segments and primes nephron progenitors for differentiation.	SLC12A1 SLC12A3	2.36e-04	18	44	2	29113990
Pubmed	Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mice.	SLC12A1 SLC12A3	3.24e-04	21	44	2	19855135
Pubmed	Hepatocyte nuclear factor 1β controls nephron tubular development.	SLC12A1 SLC12A3	3.89e-04	23	44	2	23362349
Pubmed	Grainyhead-related transcription factor is required for duct maturation in the salivary gland and the kidney of the mouse.	SLC12A1 SLC12A3	4.24e-04	24	44	2	17079272
Pubmed	Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney.	SLC12A1 SLC12A3	4.24e-04	24	44	2	17036046
Pubmed	Mouse chromosomal location of three epithelial sodium channel subunit genes and an apical sodium chloride cotransporter gene.	SLC12A1 SLC12A3	4.61e-04	25	44	2	8617496
Pubmed	Hnf1b and Pax2 cooperate to control different pathways in kidney and ureter morphogenesis.	SLC12A1 SLC12A3	4.61e-04	25	44	2	22511595
Pubmed	Dicer regulates the development of nephrogenic and ureteric compartments in the mammalian kidney.	SLC12A1 SLC12A3	4.99e-04	26	44	2	20944551
Pubmed	Hypoxia-inducible factor prolyl-4-hydroxylation in FOXD1 lineage cells is essential for normal kidney development.	SLC12A1 SLC12A3	5.79e-04	28	44	2	28847650
Pubmed	The human olfactory receptor gene family.	OR2Z1 OR10P1 OR5AN1 OR9A2 OR10D4P	5.89e-04	541	44	5	14983052
Pubmed	Genetical genomic determinants of alcohol consumption in rats and humans.	SLC6A11 GRIN1 PDYN	6.04e-04	130	44	3	19874574
Pubmed	Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.	ATP6V0A1 CANX	6.21e-04	29	44	2	12643545
Pubmed	A genetic linkage map of mouse chromosome 2 extending from thrombospondin to paired box gene 1, including the H3 minor histocompatibility complex.	SLC12A1 PRNP	6.21e-04	29	44	2	8617512
Pubmed	Sox11 gene disruption causes congenital anomalies of the kidney and urinary tract (CAKUT).	SLC12A1 SLC12A3	7.11e-04	31	44	2	29459093
Pubmed	The unfolded protein response: integrating stress signals through the stress sensor IRE1α.	DERL1 CANX	7.11e-04	31	44	2	22013210
Pubmed	Tet2- and Tet3- Mediated Cytosine Hydroxymethylation in Six2 Progenitor Cells in Mice Is Critical for Nephron Progenitor Differentiation and Nephron Endowment.	SLC12A1 SLC12A3	8.06e-04	33	44	2	36522157
Pubmed	Disruption of mitochondrial complex III in cap mesenchyme but not in ureteric progenitors results in defective nephrogenesis associated with amino acid deficiency.	SLC12A1 SLC12A3	8.55e-04	34	44	2	35341793
Pubmed	The core SWI/SNF catalytic subunit Brg1 regulates nephron progenitor cell proliferation and differentiation.	SLC12A1 SLC12A3	9.06e-04	35	44	2	32504627
Pubmed	Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model.	SLC12A1 SLC12A3	9.59e-04	36	44	2	33737325
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	GRIN1 ATP6V0A1 CANX DYRK1B	9.65e-04	347	44	4	17114649
Pubmed	Expansion of the renal capsular stroma, ureteric bud branching defects and cryptorchidism in mice with Wilms tumor 1 gene deletion in the stromal compartment of the developing kidney.	SLC12A1 SLC12A3	1.07e-03	38	44	2	32715478
Pubmed	HNF1B controls proximal-intermediate nephron segment identity in vertebrates by regulating Notch signalling components and Irx1/2.	SLC12A1 SLC12A3	1.18e-03	40	44	2	23362348
GeneFamily	Solute carriers	SLC6A11 SLC12A1 SLC12A3 SLC12A4 SLC47A2 SLC2A11 SLC22A5	5.66e-07	395	24	7	752
GeneFamily	Olfactory receptors, family 10	OR10P1 OR10D4P	3.44e-03	66	24	2	157
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	IGSF8 CCR4 PRNP	1.48e-02	394	24	3	471
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Dcn-Excitatory_Neuron.Slc17a7.Dcn-Camk2d_(CA1_Principal_cells)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	OTOP2 ELOVL3 KERA PKHD1L1	3.17e-07	59	43	4	55954d610f5a813ef15ab5e898c5ad309fc9e319
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Dcn\|Hippocampus / BrainAtlas - Mouse McCarroll V32	OTOP2 ELOVL3 KERA PKHD1L1	3.17e-07	59	43	4	ebc80c32b56e97c3ab3ac5ae00f06f7f2bcc3d39
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Dcn-Excitatory_Neuron.Slc17a7.Dcn-Camk2d_(CA1_Principal_cells)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	OTOP2 ELOVL3 KERA PKHD1L1	3.17e-07	59	43	4	719728ed089762ae79cbfbe56c4171d70361a772
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Gata3_(Periacqueductal_gray_(PAG)_(or_adjacent_APTD))--\|Thalamus / BrainAtlas - Mouse McCarroll V32	OTOP2 SLC12A1 PKHD1L1	2.30e-05	57	43	3	9614fe2acc6ee039383504f94bbe6d35aac27f25
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Gata3_(Periacqueductal_gray_(PAG)_(or_adjacent_APTD))-\|Thalamus / BrainAtlas - Mouse McCarroll V32	OTOP2 SLC12A1 PKHD1L1	2.30e-05	57	43	3	3c55a5598a7ea789500f2fbd35c79d2b97a3fc7d
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Gata3_(Periacqueductal_gray_(PAG)_(or_adjacent_APTD))\|Thalamus / BrainAtlas - Mouse McCarroll V32	OTOP2 SLC12A1 PKHD1L1	2.30e-05	57	43	3	309b3d48bfe215d7b581722c06d444b5b2ef6a30
Computational	Genes in the cancer module 162.	SLC6A11 SLC12A1 SLC12A3	5.24e-06	19	20	3	MODULE_162
Computational	Genes in the cancer module 218.	SLC6A11 SLC12A1 SLC12A3	6.15e-06	20	20	3	MODULE_218
Computational	Peptide and AA transporters.	SLC12A1 SLC12A3	4.94e-04	18	20	2	MODULE_368
Drug	carmustine; Up 200; 100uM; MCF7; HT_HG-U133A	LMF1 CACFD1 TMCO3 DMBT1 SLC2A11	3.32e-05	196	43	5	6888_UP
Drug	Tolmetin sodium salt dihydrate [64490-92-2]; Up 200; 12.6uM; PC3; HT_HG-U133A	KERA CCR4 GRIN1 PTGER1 DYRK1B	3.40e-05	197	43	5	4088_UP
Drug	Quinethazone	SLC12A1 SLC12A3	3.47e-05	5	43	2	DB01325
Drug	Bumetanide	SLC12A1 SLC12A4	3.47e-05	5	43	2	DB00887
Drug	Trichlormethiazide	SLC12A4 SLC47A2	3.47e-05	5	43	2	ctd:D014237
Disease	Involuntary Movements	GRIN1 PDYN	4.54e-05	7	44	2	C0427086
Disease	epilepsy (implicated_via_orthology)	PRKG1 SLC12A1 SLC12A3 SLC12A4	1.03e-04	163	44	4	DOID:1826 (implicated_via_orthology)
Disease	Mechanical Allodynia	GRIN1 PTGER1 PDYN	2.71e-04	84	44	3	C2936719
Disease	Hyperalgesia	GRIN1 PTGER1 PDYN	2.71e-04	84	44	3	C0020429
Disease	Allodynia	GRIN1 PTGER1 PDYN	2.71e-04	84	44	3	C0458247
Disease	Hyperalgesia, Secondary	GRIN1 PTGER1 PDYN	2.71e-04	84	44	3	C0751212
Disease	Hyperalgesia, Primary	GRIN1 PTGER1 PDYN	2.71e-04	84	44	3	C0751211
Disease	Hyperalgesia, Thermal	GRIN1 PTGER1 PDYN	2.71e-04	84	44	3	C0751214
Disease	Tactile Allodynia	GRIN1 PTGER1 PDYN	2.71e-04	84	44	3	C0751213
Disease	Sezary Syndrome	CCR4 PRKG1	7.45e-04	27	44	2	C0036920
Disease	nephrolithiasis	DMBT1 PTGER1	1.11e-03	33	44	2	EFO_0004253
Disease	Celiac Disease	CCR4 SOAT2	2.25e-03	47	44	2	C0007570
Disease	Pain, Migratory	GRIN1 PDYN	2.44e-03	49	44	2	C0751407
Disease	Suffering, Physical	GRIN1 PDYN	2.44e-03	49	44	2	C0751408
Disease	Radiating pain	GRIN1 PDYN	2.44e-03	49	44	2	C0234254
Disease	Pain, Burning	GRIN1 PDYN	2.44e-03	49	44	2	C0234230
Disease	Ache	GRIN1 PDYN	2.44e-03	49	44	2	C0234238
Disease	Pain, Crushing	GRIN1 PDYN	2.44e-03	49	44	2	C0458259
Disease	Pain, Splitting	GRIN1 PDYN	2.44e-03	49	44	2	C0458257
Disease	Pain	GRIN1 PDYN	2.44e-03	49	44	2	C0030193

Protein segments in the cluster

Peptide	Gene	Start	Entry
CIVWMLALGGFLTMI	GPR34	176	Q9UPC5
GVWMIMNAFILLLCE	CACFD1	61	Q9UGQ2
GLGLCKMISWMYLVG	CCR4	106	P51679
MWSLGCILVEMHTGE	DYRK1B	296	Q9Y463
DVWSMGILLYVLMCG	MELK	191	Q14680
HRVCFMLATGTWMIG	OR10D4P	136	Q8NGN7
MLMEACLGGELWTIL	PRKG1	436	Q13976
QCVCALLMGVVWMGG	OR4C46	136	A6NHA9
CLLMMGSSWVVGVLN	OR2Z1	141	Q8NG97
MAWQGLVLAACLLMF	PDYN	1	P01213
GIMVVSCICWSPMLV	PTGER1	301	P34995
WICIVITGLAMDMQL	DERL1	106	Q9BUN8
LITGIMFMGSGLIWR	MRS2	376	Q9HD23
LCVWMVLGAYMTGLT	OR5AN1	141	Q8NGI8
CGLMFTLTTNLAIWM	OTOP2	171	Q7RTS6
LCQMTEGSWILVGMA	PRSS36	771	Q5K4E3
LLLLMLGMGCWAREV	IGSF8	16	Q969P0
CGALMWIMLILVGLG	SLC2A11	411	Q9BYW1
CRMEGFSLFLAMLWG	LINC01555	91	Q8NAE3
IFSILGAVRMWGIMG	ELOVL3	76	Q9HB03
MEGKWLLCMLLVLGT	CANX	1	P27824
MGISTVILEMCLLWG	DMBT1	1	Q9UGM3
WRMLLVALTMPGVLC	SLC22A5	256	O76082
IVPMMLWGLLFLGCR	OR9A2	76	Q8NGT5
ACMAMVGTSWLTGII	OR10P1	141	Q8NGE3
RIMGLWLGMLACVFL	SLC47A2	466	Q86VL8
CYMTLLMIAFGLLWG	TMCO3	356	Q6UWJ1
FLSLGLMMLVCGLVW	PIRT	96	P0C851
MAGTICFIMWVLFIT	KERA	1	O60938
MWVSLFGAVLCCAVM	SLC12A1	606	Q13621
MMGCWILNEGLSTIL	NOX3	1	Q9HBY0
GMIFLTMIWAICPRD	OMA1	351	Q96E52
LGMSLCLALMFVSSW	SLC12A4	621	Q9UP95
LMWTMLFLGQGIQVS	SOAT2	476	O75908
WSVQLLCPFLMGAMR	TGFBRAP1	761	Q8WUH2
VTMLLVGGLGWCFMV	TMEM250	121	H0YL14
MANLGCWMLVLFVAT	PRNP	1	P04156
GVMIRCMLNIWGVIL	SLC12A3	141	P55017
YGIGWLMALSSMLCI	SLC6A11	551	P48066
ISCLVGRMWLLEIFM	PKHD1L1	4216	Q86WI1
GHGILMTLFAVWMVL	ATP6V0A1	411	Q93050
WIAFTGMILFCMAAL	MOSMO	101	Q8NHV5
LITGCANMLLMAALW	LMF1	141	Q96S06
ILGMVWAGFAMIIVA	GRIN1	631	Q05586