Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	SUMO ligase activity	RGPD4 RGPD1 PIAS4 RGPD3	1.25e-05	20	147	4	GO:0061665
GeneOntologyMolecularFunction	CTP synthase activity	CTPS2 CTPS1	5.38e-05	2	147	2	GO:0003883
GeneOntologyMolecularFunction	SUMO transferase activity	RGPD4 RGPD1 PIAS4 RGPD3	1.38e-04	36	147	4	GO:0019789
GeneOntologyMolecularFunction	hemi-methylated DNA-binding	EGR1 UHRF1	1.61e-04	3	147	2	GO:0044729
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	RGPD4 UBR2 UBE4B RGPD1 TRIM71 FBXO30 PIAS4 UBR5 RGPD3 TRIM55 UHRF1	1.80e-04	398	147	11	GO:0061659
GeneOntologyMolecularFunction	cytoskeletal motor activity	DNHD1 DNAH3 KIF1A MYH14 MYO15A KIF2C	2.41e-04	118	147	6	GO:0003774
GeneOntologyMolecularFunction	H3K9me3 modified histone binding	KDM4C UHRF1	3.20e-04	4	147	2	GO:0062072
GeneOntologyBiologicalProcess	positive regulation of glucokinase activity	RGPD4 RGPD1 RGPD3	2.83e-05	9	146	3	GO:0033133
GeneOntologyBiologicalProcess	positive regulation of hexokinase activity	RGPD4 RGPD1 RGPD3	4.02e-05	10	146	3	GO:1903301
GeneOntologyBiologicalProcess	'de novo' CTP biosynthetic process	CTPS2 CTPS1	4.98e-05	2	146	2	GO:0044210
GeneOntologyCellularComponent	cytoplasmic periphery of the nuclear pore complex	RGPD4 RGPD1 RGPD3	1.90e-05	8	148	3	GO:1990723
GeneOntologyCellularComponent	nuclear pore cytoplasmic filaments	RGPD4 RGPD1 RGPD3	4.02e-05	10	148	3	GO:0044614
GeneOntologyCellularComponent	annulate lamellae	RGPD4 RGPD1 RGPD3	1.20e-04	14	148	3	GO:0005642
GeneOntologyCellularComponent	cytoophidium	CTPS2 CTPS1	1.49e-04	3	148	2	GO:0097268
GeneOntologyCellularComponent	nuclear pore nuclear basket	RGPD4 RGPD1 RGPD3	2.62e-04	18	148	3	GO:0044615
GeneOntologyCellularComponent	nuclear inclusion body	RGPD4 RGPD1 RGPD3	3.63e-04	20	148	3	GO:0042405
GeneOntologyCellularComponent	SUMO ligase complex	RGPD4 RGPD1 RGPD3	4.21e-04	21	148	3	GO:0106068
GeneOntologyCellularComponent	microtubule associated complex	DNHD1 DYNLT2B DNAH3 KIF1A EML2 KIF2C	1.02e-03	161	148	6	GO:0005875
GeneOntologyCellularComponent	U2AF complex	ZRSR2 ZRSR2P1	1.02e-03	7	148	2	GO:0089701
Domain	Rab_bind	RGPD4 RGPD1 RGPD3	1.50e-05	7	143	3	PF16704
Domain	GCC2_Rab_bind	RGPD4 RGPD1 RGPD3	1.50e-05	7	143	3	IPR032023
Domain	-	RGPD4 RGPD1 RGPD3	5.07e-05	10	143	3	1.10.220.60
Domain	CTP_synthase_N	CTPS2 CTPS1	5.82e-05	2	143	2	IPR017456
Domain	GATase1_CTP_Synthase	CTPS2 CTPS1	5.82e-05	2	143	2	IPR033828
Domain	CTP_synthase	CTPS2 CTPS1	5.82e-05	2	143	2	IPR004468
Domain	CTP_synth_N	CTPS2 CTPS1	5.82e-05	2	143	2	PF06418
Domain	Grip	RGPD4 RGPD1 RGPD3	6.93e-05	11	143	3	SM00755
Domain	GRIP	RGPD4 RGPD1 RGPD3	6.93e-05	11	143	3	PF01465
Domain	Ran_BP1	RGPD4 RGPD1 RGPD3	9.19e-05	12	143	3	PF00638
Domain	RANBD1	RGPD4 RGPD1 RGPD3	9.19e-05	12	143	3	PS50196
Domain	GRIP_dom	RGPD4 RGPD1 RGPD3	9.19e-05	12	143	3	IPR000237
Domain	GRIP	RGPD4 RGPD1 RGPD3	9.19e-05	12	143	3	PS50913
Domain	RanBD	RGPD4 RGPD1 RGPD3	1.19e-04	13	143	3	SM00160
Domain	Ran_bind_dom	RGPD4 RGPD1 RGPD3	1.19e-04	13	143	3	IPR000156
Domain	Znf_C2H2-like	ZNF234 ZNF658 ADNP2 ZNF529 ZNF599 EGR1 ZNF827 MZF1 SF3A3 ZBTB40 ZNF324 ZNF740 PRMT3 DHX34 PRDM16 ZNF367	3.99e-04	796	143	16	IPR015880
Domain	ZnF_C2H2	ZNF234 ZNF658 ADNP2 ZNF529 ZNF599 EGR1 ZNF827 MZF1 SF3A3 ZBTB40 ZNF324 ZNF740 PRMT3 DHX34 PRDM16 ZNF367	4.70e-04	808	143	16	SM00355
Domain	U2AF_small	ZRSR2 ZRSR2P1	5.73e-04	5	143	2	IPR009145
Domain	GATase	CTPS2 CTPS1	5.73e-04	5	143	2	PF00117
Domain	GATASE_TYPE_1	CTPS2 CTPS1	8.56e-04	6	143	2	PS51273
Domain	GATASE	CTPS2 CTPS1	8.56e-04	6	143	2	IPR017926
Domain	WxxW_domain	MUC5B MUC5AC	8.56e-04	6	143	2	IPR025155
Domain	Mucin2_WxxW	MUC5B MUC5AC	8.56e-04	6	143	2	PF13330
Domain	Ephrin_rec_like	SVEP1 TG EPHA1	8.93e-04	25	143	3	SM01411
Domain	Tyr-kin_ephrin_A/B_rcpt-like	SVEP1 TG EPHA1	8.93e-04	25	143	3	IPR011641
Domain	P2X_receptor	P2RX7 P2RX6	1.19e-03	7	143	2	PF00864
Domain	P2X_purnocptor	P2RX7 P2RX6	1.19e-03	7	143	2	IPR001429
Domain	-	P2RX7 P2RX6	1.19e-03	7	143	2	2.60.490.10
Domain	ZnF_UBR1	UBR2 UBR5	1.19e-03	7	143	2	SM00396
Domain	ZF_UBR	UBR2 UBR5	1.19e-03	7	143	2	PS51157
Domain	zf-UBR	UBR2 UBR5	1.19e-03	7	143	2	PF02207
Domain	Znf_UBR	UBR2 UBR5	1.19e-03	7	143	2	IPR003126
Domain	P2X_RECEPTOR	P2RX7 P2RX6	1.19e-03	7	143	2	PS01212
Domain	P2X_extracellular_dom	P2RX7 P2RX6	1.19e-03	7	143	2	IPR027309
Domain	Znf_C2H2	ZNF234 ZNF658 ADNP2 ZNF529 ZNF599 EGR1 ZNF827 MZF1 SF3A3 ZBTB40 ZNF324 ZNF740 PRMT3 PRDM16 ZNF367	1.31e-03	805	143	15	IPR007087
Pathway	REACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS	RGPD4 RGPD1 PIAS4 RGPD3 NUP160	1.71e-05	42	109	5	MM15039
Pathway	REACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS	RGPD4 RGPD1 PIAS4 RGPD3 NUP160	2.99e-05	47	109	5	MM14939
Pathway	REACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS	RGPD4 RGPD1 PIAS4 RGPD3 NUP160	4.46e-05	51	109	5	MM15151
Pathway	REACTOME_NUCLEAR_ENVELOPE_BREAKDOWN	RGPD4 RGPD1 LPIN3 RGPD3 NUP160	6.45e-05	55	109	5	MM14917
Pathway	REACTOME_AMPLIFICATION_OF_SIGNAL_FROM_THE_KINETOCHORES	RGPD4 RGPD1 PPP2R5C RGPD3 NUP160 KIF2C	1.23e-04	100	109	6	MM14561
Pathway	REACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY	RGPD4 RGPD1 RGPD3 NUP160	2.49e-04	40	109	4	MM14945
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS	RGPD4 RGPD1 RGPD3 NUP160	2.75e-04	41	109	4	MM15200
Pathway	REACTOME_MITOTIC_SPINDLE_CHECKPOINT	RGPD4 RGPD1 PPP2R5C RGPD3 NUP160 KIF2C	2.90e-04	117	109	6	MM15387
Pathway	REACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA	RGPD4 RGPD1 RGPD3 NUP160	3.31e-04	43	109	4	MM14609
Pathway	BIOCARTA_RANBP2_PATHWAY	RGPD4 RGPD1 RGPD3	3.37e-04	18	109	3	MM1549
Pathway	REACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS	RGPD4 RGPD1 PIAS4 RGPD3 NUP160	4.79e-04	84	109	5	MM14929
Pathway	REACTOME_RESOLUTION_OF_SISTER_CHROMATID_COHESION	RGPD4 RGPD1 PPP2R5C RGPD3 NUP160 KIF2C	4.90e-04	129	109	6	MM14894
Pathway	REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM	RGPD4 RGPD1 THOC2 RGPD3 NUP160	5.34e-04	86	109	5	MM15413
Pathway	REACTOME_GENE_SILENCING_BY_RNA	RGPD4 RGPD1 RGPD3 NUP160	5.48e-04	49	109	4	MM14837
Pathway	REACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS	RGPD4 RGPD1 RGPD3 NUP160	5.92e-04	50	109	4	MM14610
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_FORMINS	RGPD4 RGPD1 PPP2R5C RGPD3 NUP160 KIF2C	7.84e-04	141	109	6	MM15266
Pubmed	Systematic identification of factors for provirus silencing in embryonic stem cells.	RGPD4 RGPD1 ZMYM2 UBR5 RGPD3 SF3A3 CTPS1 TBL1X	3.44e-07	153	149	8	26365490
Pubmed	Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.	RGPD4 LAMA1 RGPD1 RGPD3	4.26e-07	15	149	4	14697343
Pubmed	Transcription factor Foxp3 and its protein partners form a complex regulatory network.	RGPD4 TNPO1 MBNL1 RGPD1 ADD1 TDRD3 RBM19 RGPD3 SF3A3 ISG20L2 CTPS1	6.35e-07	370	149	11	22922362
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	RGPD4 RANBP10 ABR ITSN1 RGPD1 ADGRB3 ZMYM2 ARHGEF11 ADD1 TDRD3 P2RX7 UBR5 RGPD3 OTUD4 TNR TBL1X KIF2C	9.00e-07	963	149	17	28671696
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	UBR2 DYNLT2B ABR RHBDF2 KIF1A UBE4B MBNL1 TMEM63C WDR27 ATP10A ITPK1 ADGRG6 PIAS4 ARHGAP6 PTPRJ RDH11 ZNF827 MYH14 ATP11A SLC4A5 TBL1X	1.64e-06	1489	149	21	28611215
Pubmed	Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.	RGPD4 RGPD1 RGPD3	2.66e-06	7	149	3	9037092
Pubmed	Complex genomic rearrangements lead to novel primate gene function.	RGPD4 RGPD1 RGPD3	2.66e-06	7	149	3	15710750
Pubmed	Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene.	RGPD4 RGPD1 RGPD3	2.66e-06	7	149	3	11353387
Pubmed	Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.	RGPD4 RGPD1 RGPD3	2.66e-06	7	149	3	30944974
Pubmed	Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation.	RGPD4 RGPD1 RGPD3	2.66e-06	7	149	3	38838144
Pubmed	Retina-specifically expressed novel subtypes of bovine cyclophilin.	RGPD4 RGPD1 RGPD3	2.66e-06	7	149	3	7559465
Pubmed	Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate.	RGPD4 RGPD1 RGPD3	2.66e-06	7	149	3	17372272
Pubmed	Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain.	RGPD4 RGPD1 RGPD3	2.66e-06	7	149	3	38657106
Pubmed	Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis.	RGPD4 RGPD1 RGPD3	2.66e-06	7	149	3	21205196
Pubmed	Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.	RGPD4 RGPD1 RGPD3	2.66e-06	7	149	3	18949001
Pubmed	Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.	RGPD4 RGPD1 RGPD3	2.66e-06	7	149	3	25187515
Pubmed	Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.	RGPD4 RGPD1 RGPD3	2.66e-06	7	149	3	8603673
Pubmed	Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).	RGPD4 RGPD1 RGPD3	2.66e-06	7	149	3	26632511
Pubmed	Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.	RGPD4 RGPD1 RGPD3	2.66e-06	7	149	3	24403063
Pubmed	Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.	RGPD4 RGPD1 RGPD3	2.66e-06	7	149	3	23818861
Pubmed	Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.	RGPD4 RGPD1 RGPD3	2.66e-06	7	149	3	23536549
Pubmed	Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization.	RGPD4 RGPD1 RGPD3	2.66e-06	7	149	3	12191015
Pubmed	Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).	RGPD4 RGPD1 RGPD3	2.66e-06	7	149	3	22821000
Pubmed	Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.	RGPD4 RGPD1 RGPD3	2.66e-06	7	149	3	20682751
Pubmed	The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.	RGPD4 RGPD1 RGPD3	4.25e-06	8	149	3	21670213
Pubmed	Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.	RGPD4 RGPD1 RGPD3	4.25e-06	8	149	3	27412403
Pubmed	Mice lacking Ran binding protein 1 are viable and show male infertility.	RGPD4 RGPD1 RGPD3	4.25e-06	8	149	3	21310149
Pubmed	The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2.	RGPD4 RGPD1 RGPD3	4.25e-06	8	149	3	22262462
Pubmed	Zap70 and downstream RanBP2 are required for the exact timing of the meiotic cell cycle in oocytes.	RGPD4 RGPD1 RGPD3	4.25e-06	8	149	3	28745977
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	RANBP10 ABR RHBDF2 UBE4B EML2 ARHGEF11 LPIN3 PIAS4 MYOF TDRD3 KANSL1 ZNF827 RBM19 MTMR3 PRKDC DHX34 PRDM16	5.66e-06	1105	149	17	35748872
Pubmed	Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.	RGPD4 RGPD1 RGPD3	6.35e-06	9	149	3	18394993
Pubmed	Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.	RGPD4 RGPD1 RGPD3	6.35e-06	9	149	3	28100513
Pubmed	Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.	RGPD4 RGPD1 RGPD3	6.35e-06	9	149	3	17887960
Pubmed	The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain.	RGPD4 RGPD1 RGPD3	6.35e-06	9	149	3	11553612
Pubmed	The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1.	RGPD4 RGPD1 RGPD3	6.35e-06	9	149	3	10601307
Pubmed	The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome.	RGPD4 RGPD1 RGPD3	6.35e-06	9	149	3	9733766
Pubmed	Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.	RGPD4 RGPD1 RGPD3	6.35e-06	9	149	3	28877029
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	DNHD1 LAMA1 PCARE THOC2 LPIN3 PES1 PRDM16 SLC4A5	8.21e-06	234	149	8	36243803
Pubmed	The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes.	RGPD4 RGPD1 RGPD3	9.05e-06	10	149	3	27160050
Pubmed	Parkin ubiquitinates and promotes the degradation of RanBP2.	RGPD4 RGPD1 RGPD3	9.05e-06	10	149	3	16332688
Pubmed	Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.	RGPD4 RGPD1 RGPD3	9.05e-06	10	149	3	8857542
Pubmed	Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.	RGPD4 RGPD1 RGPD3	9.05e-06	10	149	3	21859863
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ZNF234 KIF1A UBE4B KDM4C ZRSR2 TNPO2 ITSN1 GNPTAB ADGRB3 ADNP2 ZMYM2 BHLHE40 CORO2B MYH14 GLS MTMR3 PRKDC KLHL4	1.06e-05	1285	149	18	35914814
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	KDM4C MBNL1 ZMYM2 ZDHHC17 BHLHE40 PIAS4 JARID2 EGR1 UBP1 ZNF324 UHRF1 ZNF740 PRDM16 ZNF367	1.08e-05	808	149	14	20412781
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	TNPO1 DNHD1 KIF1A API5 GTPBP1 THOC2 JARID2 RDH11 MYH14 RBM19 PRIM1 GLS PES1 SF3A3 UHRF1 PRMT3 PRKDC CTPS1 NUP160	1.18e-05	1425	149	19	30948266
Pubmed	RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.	RGPD4 RGPD1 RGPD3	1.24e-05	11	149	3	17069463
Pubmed	Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study.	MUC5B KANSL1 MUC5AC	1.24e-05	11	149	3	24429156
Pubmed	An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age.	RGPD4 RGPD1 RGPD3	1.24e-05	11	149	3	35771867
Pubmed	T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1.	RGPD4 RGPD1 RGPD3	1.24e-05	11	149	3	34110283
Pubmed	Cloning and analysis of cDNA encoding a major airway glycoprotein, human tracheobronchial mucin (MUC5).	MUC5B MUC5AC	1.82e-05	2	149	2	7513696
Pubmed	The association between MUC5AC and MUC5B genes expression and remodeling progression in severe neutrophilic asthma: A direct relationship.	MUC5B MUC5AC	1.82e-05	2	149	2	37146737
Pubmed	MUC5AC and MUC5B Mucins Are Decreased in Cystic Fibrosis Airway Secretions.	MUC5B MUC5AC	1.82e-05	2	149	2	14988081
Pubmed	Mucin glycosylation changes in cystic fibrosis lung disease are not manifest in submucosal gland secretions.	MUC5B MUC5AC	1.82e-05	2	149	2	15563276
Pubmed	The expression of MUC5AC and MUC5B mucin genes in the mucosa of chronic rhinosinusitis and nasal polyposis.	MUC5B MUC5AC	1.82e-05	2	149	2	17621824
Pubmed	Muc5b is required for airway defence.	MUC5B MUC5AC	1.82e-05	2	149	2	24317696
Pubmed	Macrophages are related to goblet cell hyperplasia and induce MUC5B but not MUC5AC in human bronchus epithelial cells.	MUC5B MUC5AC	1.82e-05	2	149	2	22391959
Pubmed	Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules.	MUC5B MUC5AC	1.82e-05	2	149	2	35776514
Pubmed	ZRSR1 co-operates with ZRSR2 in regulating splicing of U12-type introns in murine hematopoietic cells.	ZRSR2 ZRSR2P1	1.82e-05	2	149	2	33691379
Pubmed	The RNA hairpin binder TRIM71 modulates alternative splicing by repressing MBNL1.	MBNL1 TRIM71	1.82e-05	2	149	2	31371437
Pubmed	The ocular surface phenotype of Muc5ac and Muc5b null mice.	MUC5B MUC5AC	1.82e-05	2	149	2	24327612
Pubmed	Gel-forming mucins form distinct morphologic structures in airways.	MUC5B MUC5AC	1.82e-05	2	149	2	28607090
Pubmed	Muc5b is mainly expressed and sialylated in the nasal olfactory epithelium whereas Muc5ac is exclusively expressed and fucosylated in the nasal respiratory epithelium.	MUC5B MUC5AC	1.82e-05	2	149	2	31030254
Pubmed	The idiopathic pulmonary fibrosis honeycomb cyst contains a mucocilary pseudostratified epithelium.	MUC5B MUC5AC	1.82e-05	2	149	2	23527003
Pubmed	Up-regulation of MUC5AC and MUC5B mucin genes in nasopharyngeal respiratory mucosa and selective up-regulation of MUC5B in middle ear in pediatric otitis media with effusion.	MUC5B MUC5AC	1.82e-05	2	149	2	16540890
Pubmed	Abnormalities in MUC5AC and MUC5B Protein in Airway Mucus in Asthma.	MUC5B MUC5AC	1.82e-05	2	149	2	27845589
Pubmed	DNA-PKcs kinase activity stabilizes the transcription factor Egr1 in activated immune cells.	EGR1 PRKDC	1.82e-05	2	149	2	34562454
Pubmed	Contribution of mucus concentration and secreted mucins Muc5ac and Muc5b to the pathogenesis of muco-obstructive lung disease.	MUC5B MUC5AC	1.82e-05	2	149	2	27435107
Pubmed	Mucins MUC5B and MUC5AC in Distal Airways and Honeycomb Spaces: Comparison among Idiopathic Pulmonary Fibrosis/Usual Interstitial Pneumonia, Fibrotic Nonspecific Interstitial Pneumonitis, and Control Lungs.	MUC5B MUC5AC	1.82e-05	2	149	2	26871672
Pubmed	EGR1 transcriptionally regulates SVEP1 to promote proliferation and migration in human coronary artery smooth muscle cells.	SVEP1 EGR1	1.82e-05	2	149	2	38409611
Pubmed	In silico cloning of mouse Muc5b gene and upregulation of its expression in mouse asthma model.	MUC5B MUC5AC	1.82e-05	2	149	2	11587997
Pubmed	Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins.	TNPO1 TNPO2	1.82e-05	2	149	2	9298975
Pubmed	Pathophysiological relevance of sputum MUC5AC and MUC5B levels in patients with mild asthma.	MUC5B MUC5AC	1.82e-05	2	149	2	34656442
Pubmed	Airway mucin MUC5AC and MUC5B concentrations and the initiation and progression of chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort.	MUC5B MUC5AC	1.82e-05	2	149	2	34058148
Pubmed	Early growth response factor 1 is essential for cigarette smoke-induced MUC5AC expression in human bronchial epithelial cells.	EGR1 MUC5AC	1.82e-05	2	149	2	28602698
Pubmed	C-Mannosylation of MUC5AC and MUC5B Cys subdomains.	MUC5B MUC5AC	1.82e-05	2	149	2	14718370
Pubmed	Transportin-1 and Transportin-2: protein nuclear import and beyond.	TNPO1 TNPO2	1.82e-05	2	149	2	24780099
Pubmed	Mucin production during prenatal and postnatal murine lung development.	MUC5B MUC5AC	1.82e-05	2	149	2	21653907
Pubmed	MUC5B mobilizes and MUC5AC spatially aligns mucociliary transport on human airway epithelium.	MUC5B MUC5AC	1.82e-05	2	149	2	36427316
Pubmed	Mucin deficiency causes functional and structural changes of the ocular surface.	MUC5B MUC5AC	1.82e-05	2	149	2	23272068
Pubmed	Younger patients with COME are more likely to have mucoid middle ear fluid containing mucin MUC5B.	MUC5B MUC5AC	1.82e-05	2	149	2	27729120
Pubmed	Zrsr2 and functional U12-dependent spliceosome are necessary for follicular development.	ZRSR2 ZRSR2P1	1.82e-05	2	149	2	35198906
Pubmed	De novo NUF2 variant in a novel inherited bone marrow failure syndrome including microcephaly and renal hypoplasia.	MUC5B MUC5AC	1.82e-05	2	149	2	36111525
Pubmed	Normal murine respiratory tract has its mucus concentrated in clouds based on the Muc5b mucin.	MUC5B MUC5AC	1.82e-05	2	149	2	32348677
Pubmed	UHRF1 Controls Thymocyte Fate Decisions through the Epigenetic Regulation of EGR1 Expression.	EGR1 UHRF1	1.82e-05	2	149	2	32358021
Pubmed	Reassessment of the importance of mucins in determining sputum properties in cystic fibrosis.	MUC5B MUC5AC	1.82e-05	2	149	2	24332705
Pubmed	Regulation of human cytidine triphosphate synthetase 2 by phosphorylation.	CTPS2 CTPS1	1.82e-05	2	149	2	20739275
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	UBE4B ADNP2 KANSL1 RDH11 UBR5 MYH14 RBM19 GLS PES1 SF3A3 PRMT3 PRR14L PRKDC CTPS1 ALDH9A1 DHX34 NUP160 KIF2C	2.11e-05	1353	149	18	29467282
Pubmed	Peering through the pore: nuclear pore complex structure, assembly, and function.	RGPD4 RGPD1 RGPD3 NUP160	2.13e-05	38	149	4	12791264
Pubmed	Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons.	RGPD4 RGPD1 RGPD3	2.14e-05	13	149	3	31427429
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	UBE4B ITSN1 ZMYM2 THOC2 ADD1 CLASRP TUBGCP6 MYOF KANSL1 ZBTB40 OTUD4 PRKDC CTPS1	3.10e-05	774	149	13	15302935
Pubmed	Charting the landscape of tandem BRCT domain-mediated protein interactions.	DNHD1 MRM2 DYNLT2B ABR CLASRP RCC1L PPP2R5C UBR5 MYH14 PRIM1 ALDH9A1 KIF2C	3.41e-05	670	149	12	22990118
Pubmed	Defining the membrane proteome of NK cells.	GAK EDC3 ABR API5 GTPBP1 TUBGCP6 UBR5 MYH14 RBM19 PRIM1 PES1 ATP11A PRKDC CTPS1 DHX34 KIF2C	4.42e-05	1168	149	16	19946888
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	ZMYM2 GTPBP1 THOC2 ADD1 UBP1 SF3A3 OTUD4 ZNF740 PRKDC CTPS1 NUP160	4.59e-05	583	149	11	29844126
Pubmed	A human MAP kinase interactome.	ITSN1 ADNP2 ZMYM2 ZDHHC17 ARHGEF11 BHLHE40 FBXO30 KANSL1 EGR1 PRKDC	5.01e-05	486	149	10	20936779
Pubmed	Expression of Human CTP synthetase in Saccharomyces cerevisiae reveals phosphorylation by protein kinase A.	CTPS2 CTPS1	5.45e-05	3	149	2	16179339
Pubmed	Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1.	ZRSR2 ZRSR2P1	5.45e-05	3	149	2	8586425
Pubmed	High-Mobility Group Box 1 Upregulates MUC5AC and MUC5B Expression in Primary Airway Epithelial Cells.	MUC5B MUC5AC	5.45e-05	3	149	2	29286856
Pubmed	Nebulized Menthol Impairs Mucociliary Clearance via TRPM8 and MUC5AC/MUC5B in Primary Airway Epithelial Cells.	MUC5B MUC5AC	5.45e-05	3	149	2	36675209
Pubmed	Th2 cytokines orchestrate the secretion of MUC5AC and MUC5B in IL-5-positive chronic rhinosinusitis with nasal polyps.	MUC5B MUC5AC	5.45e-05	3	149	2	29802623
Pubmed	Resistin upregulates MUC5AC/B mucin gene expression in human airway epithelial cells.	MUC5B MUC5AC	5.45e-05	3	149	2	29604272
Interaction	TIGD3 interactions	NAT16 ARHGEF11 CTPS2 CTPS1	1.80e-06	13	146	4	int:TIGD3
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF234 ZNF658 ADNP2 ZNF529 ZNF599 EGR1 ZNF827 MZF1 ZBTB40 ZNF324 ZNF740 PRDM16 ZNF367	4.19e-04	718	110	13	28
GeneFamily	Purinergic receptors P2X	P2RX7 P2RX6	7.55e-04	7	110	2	214
GeneFamily	Ubiquitin protein ligase E3 component n-recognins	UBR2 UBR5	7.55e-04	7	110	2	785
GeneFamily	Olfactory receptors, family 14	OR14J1 OR14K1	7.55e-04	7	110	2	163
GeneFamily	Zinc fingers CCCH-type	ZRSR2 MBNL1 ZRSR2P1	1.24e-03	35	110	3	73
GeneFamily	Tudor domain containing	KDM4C TDRD3 UHRF1	1.46e-03	37	110	3	780
GeneFamily	Myotubularins\|Phosphoinositide phosphatases	MTMR12 MTMR3	3.66e-03	15	110	2	903
GeneFamily	ATPase phospholipid transporting	ATP10A ATP11A	3.66e-03	15	110	2	1210
GeneFamily	Armadillo repeat containing\|Importins	TNPO1 TNPO2	5.27e-03	18	110	2	596
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	RGPD4 RGPD1 RGPD3 WDTC1	5.35e-03	115	110	4	769
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	UBR2 SEMA3C KDM4C ITSN1 MBNL1 ZMYM2 ZDHHC17 THOC2 BHLHE40 ADGRG6 JARID2 MYOF TDRD3 PPP2R5C UBR5 MTMR3 OTUD4 PRMT3 NUP160 TBL1X	6.46e-08	856	146	20	M4500
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN	UBR2 SEMA3C ITSN1 MBNL1 ZMYM2 ZDHHC17 BHLHE40 ADGRG6 JARID2 PPP2R5C UBR5 PRMT3 TBL1X	2.23e-06	466	146	13	M13522
Coexpression	NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP	TNPO1 UBR2 KIF1A UBE4B ANKRD10 MBNL1 ZMYM2 API5 THOC2 ATP10A ADD1 TDRD3 PPP2R5C RDH11 UBR5 EGR1 GLS KCTD20 OTUD4 PRKDC NUP160	3.97e-06	1215	146	21	M41122
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TRIM71 ADGRG6 MYOF MYH14 ATP11A PRDM16 RNF207	3.15e-06	186	149	7	4e94158db52df41d71e67b02b9895a358eebee0f
ToppCell	human_hepatoblastoma-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	SEMA3C ITSN1 TMEM132C MYOF UBR5 HYDIN TBL1X	3.38e-06	188	149	7	b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA1 MUC5B SVEP1 FBN2 SLC12A1 HYDIN	1.66e-05	160	149	6	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA1 MUC5B SVEP1 FBN2 SLC12A1 HYDIN	1.66e-05	160	149	6	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	LA-16._Neuronal\|World / Chamber and Cluster_Paper	SEMA3C TSPAN11 ADGRB3 ADGRG6 KIRREL3 PTPRJ	2.19e-05	168	149	6	2fd1fd2a16ac1c5eb028f93cc3a2477c7747693e
ToppCell	LA-16._Neuronal\|LA / Chamber and Cluster_Paper	SEMA3C TSPAN11 ADGRB3 ADGRG6 KIRREL3 PTPRJ	2.19e-05	168	149	6	c55bbfbde8bb954f1cb9af82007bdd1f8070fee3
ToppCell	COVID-19_Mild-PLT_2\|World / Disease Group and Platelet Clusters	DNHD1 NUDT13 ATP10A MYOF RGPD3 SF3A3	2.26e-05	169	149	6	6abfdc8b437f19c03b408bedc245059d28c6ba6a
ToppCell	COVID-19_Mild-PLT_2\|COVID-19_Mild / Disease Group and Platelet Clusters	DNHD1 NUDT13 ATP10A MYOF RGPD3 SF3A3	2.58e-05	173	149	6	d11705e56b6b21eec963ea224717f27680c781ed
ToppCell	COVID-19-Heart-Neuronal\|Heart / Disease (COVID-19 only), tissue and cell type	SEMA3C TSPAN11 ADGRB3 ADGRG6 KIRREL3 PTPRJ	2.58e-05	173	149	6	6fb5f9e6536a5d57fd8e6657b494047a2d0bc9c7
ToppCell	390C-Fibroblasts-Fibroblast-B_(Myofibroblast)\|390C / Donor, Lineage, Cell class and subclass (all cells)	TSPAN11 ADGRB3 ADGRG6 TMEM132C FBN2 SLC4A5	2.84e-05	176	149	6	852d3da0907fe87c0ef23d75a63ce07619cf0c54
ToppCell	390C-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	TSPAN11 ADGRB3 ADGRG6 TMEM132C FBN2 SLC4A5	2.84e-05	176	149	6	d2df1e435996c51213e88270af9f928e9e09a6f5
ToppCell	facs-Brain_Myeloid-Striatum-24m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GTPBP1 BHLHE40 FBXO30 KIAA0825 DPEP2 WDTC1	2.94e-05	177	149	6	f6b9d91d46830d0d207b0abd4ee5a4942fd99774
ToppCell	RA-13._Vascular_Smooth_Muscle\|RA / Chamber and Cluster_Paper	ATP10A ARHGAP6 MYOF GLS PRDM16 TBL1X	3.54e-05	183	149	6	818fd886e0188091310825f9145fa53328f2c979
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-Tuft-related\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TMEM63C MUC5B ADGRG6 CORO2B MYH14 MUC5AC	3.54e-05	183	149	6	263937906ddabc798bbe60f0da28ba859a5c72e2
ToppCell	Control-Epithelial_alveolar-AT_2-Differentiating_AT2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SEMA3C KIRREL3 MYH14 ATP11A PRDM16 SLC4A5	3.76e-05	185	149	6	0d2add28ac1f4fa6de7699be009bf8391badaf4c
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CACNA1D ADGRB3 SVEP1 ADGRG6 TMEM132C ARHGAP6	3.99e-05	187	149	6	a9316e2818217ec5feae9cf8816f7249803caee6
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA3C SLC12A1 PTPRJ GLS TRIM55 ATP11A	4.23e-05	189	149	6	8c8ca3b30d9be6c854615459a7bfba82b427c8bc
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA3C SLC12A1 PTPRJ GLS TRIM55 ATP11A	4.23e-05	189	149	6	5d902a4660a27548764bf04c6de152b565da835c
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1D ADGRB3 SVEP1 TMEM132C ARHGAP6 MYOF	4.23e-05	189	149	6	2a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCell	3'-Child09-12-SmallIntestine-Neuronal-Glial_mature\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SEMA3C TSPAN11 KIF1A ADGRB3 KIRREL3 PRDM16	4.62e-05	192	149	6	ac507fd7cf3b3e521a15ef03bb4e81eb23807985
ToppCell	3'-Child09-12-SmallIntestine-Neuronal\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SEMA3C TSPAN11 KIF1A ADGRB3 KIRREL3 PRDM16	4.62e-05	192	149	6	24f40dadec04f4f99c31000fa9f09d07148fa190
ToppCell	3'-Child09-12-SmallIntestine-Neuronal-Glial_mature-Adult_Glia\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SEMA3C TSPAN11 KIF1A ADGRB3 KIRREL3 PRDM16	4.62e-05	192	149	6	71e04e197825856c6d4278fc76c58ab17ffa2387
ToppCell	nucseq\|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	KDM4C MBNL1 TG JARID2 KANSL1 PTPRJ	4.76e-05	193	149	6	779276e775cb2492e8dd36436295a536084a6415
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TMEM132C FBN2 EGR1 PRIM1 UHRF1 ZNF367	4.76e-05	193	149	6	f25bdd10ef531b8d8441ea84573078b4b1b0f105
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA1 ARHGAP6 SLC12A1 PTPRJ PRDM16 HYDIN	4.90e-05	194	149	6	93c68c31e39fa44c1d05d7d4997f4f086da4e738
ToppCell	3'-Pediatric_IBD-SmallIntestine-Neuronal-Glial_mature-Adult_Glia\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SEMA3C TSPAN11 ADGRB3 KIRREL3 TMEM59L PRDM16	4.90e-05	194	149	6	d429bb5e422a07bd92f0dc48cd51528e8b7d9a72
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1D ADGRB3 SVEP1 TMEM132C ARHGAP6 MYOF	4.90e-05	194	149	6	89b706af2b25991fc2707eb24f49ba6ff3ae01f7
ToppCell	3'-Pediatric_IBD-SmallIntestine-Neuronal\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SEMA3C TSPAN11 ADGRB3 KIRREL3 TMEM59L PRDM16	4.90e-05	194	149	6	bffdf6db0bf3fb338e7bb0789ae7dcde1fce0094
ToppCell	3'-Pediatric_IBD-SmallIntestine-Neuronal-Glial_mature\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SEMA3C TSPAN11 ADGRB3 KIRREL3 TMEM59L PRDM16	4.90e-05	194	149	6	408dfc7060095972a54ae37ae8105521df6fbbee
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	DDX11 PRIM1 UHRF1 PRKDC CTPS1 ZNF367	5.04e-05	195	149	6	cec7df321f372d05c94f97d6bb18891a5cc3dec3
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	DDX11 PRIM1 UHRF1 PRKDC CTPS1 ZNF367	5.18e-05	196	149	6	df366d76ea55f49e349d622effa57c1535df8400
ToppCell	(02)_MMP9/10+-(1)_GFP\|(02)_MMP9/10+ / shred by cell type by condition	SEMA3C ABR MUC5B JARID2 CORO2B GLS	5.64e-05	199	149	6	448ba982be804007f991d469eca9d885b21ae499
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	UBR2 KDM4C ADGRB3 KANSL1 PTPRJ UBR5	5.64e-05	199	149	6	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	LPS_only-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_only / Treatment groups by lineage, cell group, cell type	CACNA1D ITSN1 LAMA1 SVEP1 TMEM132C MYOF	5.80e-05	200	149	6	a7ef7022b8efcaedb7319b0b43d8c4e99d788fe2
Drug	Lorglumide sodium salt [97964-56-2]; Down 200; 8.4uM; MCF7; HT_HG-U133A	KDM4C ITSN1 JARID2 MYOF MZF1 GLS MTMR3 ZNF324 DHX34 WDTC1	6.07e-07	196	147	10	5619_DN
Drug	Trifluridine [70-00-8]; Down 200; 13.6uM; MCF7; HT_HG-U133A	EDC3 TNPO2 ITSN1 ADNP2 TDRD3 MZF1 NUP160 KIF2C WDTC1	4.52e-06	192	147	9	7176_DN
Drug	Benfotiamine [22457-89-2]; Up 200; 8.6uM; MCF7; HT_HG-U133A	ANG ABR GNPTAB SVEP1 MYOF EGR1 ZNF324 ATP11A DHX34	5.35e-06	196	147	9	3837_UP
Drug	Catechin-(+,-) hydrate [7295-85-4]; Up 200; 13.8uM; MCF7; HT_HG-U133A	NUDT13 MYOF MYH14 KCTD20 ZNF324 THAP3 MYO15A PRDM16 WDTC1	5.57e-06	197	147	9	3351_UP
Drug	Josamycin [16846-24-5]; Down 200; 4.8uM; MCF7; HT_HG-U133A	CACNA1D RANBP10 KIF1A PIAS4 MYOF KCTD20 ZNF324 SECISBP2 PRR14L	5.81e-06	198	147	9	1534_DN
Drug	Cinnarizine [298-57-7]; Down 200; 10.8uM; PC3; HT_HG-U133A	RANBP10 DNAH3 EDC3 ANG PGGT1B MYOF MZF1 THAP3 DHX34	6.05e-06	199	147	9	5817_DN
Drug	Moxisylyte hydrochoride [964-52-3]; Up 200; 12.6uM; HL60; HT_HG-U133A	ITSN1 ZMYM2 RDH11 MZF1 ZNF324 ATP11A EPHA1 TBL1X WDTC1	6.30e-06	200	147	9	1846_UP
Drug	Mometasone furoate [83919-23-7]; Down 200; 7.6uM; PC3; HT_HG-U133A	ABR ANKRD10 MUC5B FBN2 GLS ZBTB40 TBL1X WDTC1	3.12e-05	188	147	8	5116_DN
Drug	Pentamidine isethionate [140-64-7]; Down 200; 6.8uM; HL60; HT_HG-U133A	RHBDF2 ARHGEF11 PGGT1B FBN2 KCTD20 ZBTB40 ATP11A NUP160	4.20e-05	196	147	8	2473_DN
Drug	Tranylcypromine hydrochloride [1986-47-6]; Up 200; 23.6uM; PC3; HT_HG-U133A	ITSN1 SVEP1 ITPK1 CORO2B RDH11 EGR1 ALPK3 NUP160	4.20e-05	196	147	8	2101_UP
Drug	Fipexide hydrochloride [34161-23-4]; Down 200; 9.4uM; MCF7; HT_HG-U133A	ABR ARHGEF11 PIAS4 RBM19 ZNF324 EPHA1 TBL1X WDTC1	4.35e-05	197	147	8	3176_DN
Drug	Bromocryptine mesylate [22260-51-1]; Down 200; 5.4uM; PC3; HT_HG-U133A	SEMA3C ANG ABR ARHGEF11 BHLHE40 PES1 KCTD20 PRKDC	4.35e-05	197	147	8	4604_DN
Drug	LY 294002; Down 200; 0.1uM; MCF7; HT_HG-U133A	EDC3 KIF1A ZRSR2 ZMYM2 ARHGEF11 MZF1 ZNF324 NUP160	4.35e-05	197	147	8	6935_DN
Drug	Dextromethorphan hydrobromide monohydrate [6700-34-1]; Down 200; 10.8uM; MCF7; HT_HG-U133A	ARHGEF11 PGGT1B PES1 ZBTB40 ATP11A DHX34 TBL1X WDTC1	4.35e-05	197	147	8	2636_DN
Drug	Hydroflumethiazide [135-09-1]; Up 200; 12uM; HL60; HT_HG-U133A	KIF1A MYOF MYH14 MTMR3 ZBTB40 ZNF324 THAP3 DHX34	4.51e-05	198	147	8	1851_UP
Drug	Isradipine [75695-93-1]; Up 200; 10.8uM; PC3; HT_HG-U133A	MTMR12 UBE4B KDM4C ITSN1 ZMYM2 TDRD3 EGR1 DHX34	4.51e-05	198	147	8	6347_UP
Drug	Butirosin disulfate salt [51022-98-1]; Down 200; 5.4uM; MCF7; HT_HG-U133A	KDM4C GNPTAB ZMYM2 PIAS4 MYOF MTMR3 THAP3 WDTC1	4.51e-05	198	147	8	6080_DN
Drug	Ozagrel hydrochloride [78712-43-3]; Up 200; 15.2uM; PC3; HT_HG-U133A	RHBDF2 ADNP2 ZDHHC17 ARHGEF11 PGGT1B RBM19 DHX34 MUC5AC	4.67e-05	199	147	8	7281_UP
Drug	Gliclazide [21187-98-4]; Down 200; 12.4uM; HL60; HG-U133A	UBR2 GNPTAB BHLHE40 NUDT13 UBR5 MZF1 MYH14 GLS	4.84e-05	200	147	8	1720_DN
Disease	intellectual developmental disorder with hypotonia, impaired speech, and dysmorphic facies (implicated_via_orthology)	TNPO1 TNPO2	2.37e-05	2	144	2	DOID:0081262 (implicated_via_orthology)
Disease	chronic obstructive pulmonary disease, interleukin-8 measurement	P2RX7 HYDIN	1.41e-04	4	144	2	EFO_0000341, EFO_0004811
Disease	idiopathic pulmonary fibrosis	MUC5B KANSL1 ATP11A MUC5AC	1.76e-04	57	144	4	EFO_0000768
Disease	platelet crit	TNPO1 DNAH3 SLFN14 ARHGEF11 ITPK1 LPIN3 KANSL1 PRIM1 OTUD4 ISG20L2 CTPS1 PRDM16 NUP160 ZNF367	2.44e-04	952	144	14	EFO_0007985
Disease	severe acute respiratory syndrome, COVID-19	TG TMEM132C JARID2 ARHGAP6 KIRREL3 ATP11A TNR TBL1X KLHL4	3.64e-04	447	144	9	EFO_0000694, MONDO_0100096
Disease	red blood cell density measurement	SEMA3C ITSN1 MBNL1 ARHGEF11 TG KANSL1 UBR5 ZNF827 DPEP2 ZBTB40 OTUD4 ATP11A MYO15A	3.92e-04	880	144	13	EFO_0007978
Disease	biliary tract benign neoplasm (is_marker_for)	CTPS1 MUC5AC	4.89e-04	7	144	2	DOID:0050625 (is_marker_for)
Disease	glucose measurement	MBNL1 TMEM132C PTPRJ MTMR3 ISG20L2 PRDM16 NUP160 MAP4K2	5.79e-04	380	144	8	EFO_0004468
Disease	COVID-19 symptoms measurement	MUC5B KANSL1 MUC5AC	6.64e-04	35	144	3	EFO_0600019
Disease	long QT syndrome (implicated_via_orthology)	KCNH7 ARHGAP6	1.04e-03	10	144	2	DOID:2843 (implicated_via_orthology)
Disease	aortic valve stenosis (is_marker_for)	JARID2 EGR1	1.26e-03	11	144	2	DOID:1712 (is_marker_for)
Disease	pulmonary fibrosis	MUC5B MUC5AC	1.26e-03	11	144	2	EFO_0009448
Disease	body surface area	KIF1A MBNL1 RGPD1 ITPK1 ADGRG6 FBN2 MTMR3 SF3A3 UHRF1 CTPS1	1.27e-03	643	144	10	EFO_0022196
Disease	chronic obstructive pulmonary disease (is_marker_for)	ANG MUC5B EGR1 MUC5AC	1.33e-03	97	144	4	DOID:3083 (is_marker_for)
Disease	interleukin 17 measurement	OR14J1 PTPRJ NUP160	1.39e-03	45	144	3	EFO_0008174
Disease	alkaline phosphatase measurement	BHLHE40 KIRREL3 PPP2R5C KANSL1 PTPRJ P2RX7 ZNF827 DPEP2 UBP1 ZBTB40 PRR14L NUP160 MAP4K2	1.45e-03	1015	144	13	EFO_0004533
Disease	survival time, breast carcinoma	KCNH7 TBL1X	1.78e-03	13	144	2	EFO_0000305, EFO_0000714
Disease	advanced glycosylation end product-specific receptor, soluble measurement	KANSL1 PRDM16	1.78e-03	13	144	2	EFO_0020131
Disease	mean reticulocyte volume	TNPO1 KDM4C ITSN1 GTPBP1 KANSL1 PTPRJ DPEP2 PRIM1 ZBTB40 OTUD4 PRDM16	1.93e-03	799	144	11	EFO_0010701
Disease	treatment-resistant hypertension	CACNA1D SEMA3C KDM4C PRMT3	2.04e-03	109	144	4	EFO_1002006
Disease	Hamman-Rich syndrome	MUC5B ATP11A	2.07e-03	14	144	2	C0085786
Disease	coronary artery disease	SEMA3C KCNH7 KIF1A SVEP1 ITPK1 FBN2 PTPRJ ZNF827 GLS SF3A3 UHRF1 PRDM16 NUP160 TBL1X	2.17e-03	1194	144	14	EFO_0001645
Disease	Chronic Lymphocytic Leukemia	ZRSR2 PPP2R5C P2RX7	2.48e-03	55	144	3	C0023434
Disease	lean body mass	ADGRG6 PTPRJ KIAA0825 PRIM1 MTMR3 ZBTB40 NUP160	2.67e-03	379	144	7	EFO_0004995
Disease	nervousness	PTPRJ NUP160	2.71e-03	16	144	2	NCIT_C74532
Disease	alpha-L-iduronidase measurement	GAK GNPTAB	3.07e-03	17	144	2	EFO_0020139
Disease	asthma (is_marker_for)	ANG MUC5B EGR1 MUC5AC	3.44e-03	126	144	4	DOID:2841 (is_marker_for)
Disease	Usual Interstitial Pneumonia	MUC5B ATP11A	3.83e-03	19	144	2	C4721509
Disease	Hamman-Rich Disease	MUC5B ATP11A	3.83e-03	19	144	2	C4721508
Disease	hydrocephalus (implicated_via_orthology)	ADD1 HYDIN	3.83e-03	19	144	2	DOID:10908 (implicated_via_orthology)
Disease	response to vaccine, cytokine measurement	DNAH3 ATP10A ZNF827 SLC4A5	3.95e-03	131	144	4	EFO_0004645, EFO_0004873
Disease	Familial Idiopathic Pulmonary Fibrosis	MUC5B ATP11A	4.24e-03	20	144	2	C4721952
Disease	interstitial lung disease	MUC5B ATP11A MUC5AC	4.34e-03	67	144	3	EFO_0004244
Disease	Idiopathic Pulmonary Fibrosis	MUC5B ATP11A	4.67e-03	21	144	2	C1800706
Disease	Profound Mental Retardation	LAMA1 ZMYM2 KANSL1 ZBTB40	4.87e-03	139	144	4	C0020796
Disease	Mental Retardation, Psychosocial	LAMA1 ZMYM2 KANSL1 ZBTB40	4.87e-03	139	144	4	C0025363
Disease	Mental deficiency	LAMA1 ZMYM2 KANSL1 ZBTB40	4.87e-03	139	144	4	C0917816

Protein segments in the cluster

Peptide	Gene	Start	Entry
CSTLVTAPGQHLKFQ	TMEM59L	286	Q9UK28
GPALHVFNVKCEAQR	nan	66	Q6ZRU5
TGSCFKLRTVHNIPV	ABR	476	Q12979
SVKAVQHGKPIFICQ	ACOT8	111	O14734
HNPGACVALVSVRVF	EPHA1	186	P21709
GQFLCQHPDVAKVSF	ALDH9A1	216	P49189
KQLVCPVTRDHLGFQ	CPN2	441	P22792
VFPNHISVGTNRKRC	ANKRD10	201	Q9NXR5
LVLNKVSPSQFGCHV	ADGRB3	156	O60242
LRQCFHGQVLVKTGP	ADGRG6	1206	Q86SQ4
GKNCVPVIQRTFAHS	BHLHE40	216	O14503
GQRHKVKSQGACVTP	GTPBP1	651	O00178
TKGPVLHDQDTRCAF	ALPK3	81	Q96L96
RCVIIQKDQHGFGFT	ARHGEF11	46	O15085
LAKCVSSPHFQVAER	PPP2R5C	331	Q13362
CTRQAVPLFSKNVHS	API5	241	Q9BZZ5
VHAVSFRSCPTGEKN	DNHD1	1391	Q96M86
LQPCSSVDARGRHQK	ATP10A	776	O60312
CVFASQPKVVGRHFR	ADNP2	111	Q6IQ32
TANPCSRKKVHFGSI	ANKRD42	16	Q8N9B4
AQKQCSILHGPTFAA	MUC5B	1081	Q9HC84
STQVNVPRCLHFSGV	RCC1L	321	Q96I51
VPRCLHFSGVGKVRQ	RCC1L	326	Q96I51
KVQGTVHCFPISARL	RANBP10	236	Q6VN20
TTCHTVKLRGAPFNV	RBM19	291	Q9Y4C8
SNPCVQRKSSHVGDR	OTUD4	486	Q01804
QRHSTGDTKVPFCLQ	GLS	271	O94925
KVFNGCPLRIHAAVT	MAP4K2	476	Q12851
TRHEGSFQVPVLCAV	CD69	31	Q07108
VKQVDGSFRCSPFHV	LPIN3	36	Q9BQK8
CVAGFTNITFHPQNK	PTPRJ	931	Q12913
TFPFICKTRVAHGTN	ITPK1	151	Q13572
SNNRIQVFKPCGAFH	TRIM71	626	Q2Q1W2
HALVTTECPQKGRNF	KIAA0825	321	Q8IV33
QRLTFPAVSVKVNGH	GNPTAB	786	Q3T906
PHCRTRIGFQSLIQK	MTMR12	411	Q9C0I1
IFVVTNRGQHVCPLS	MYO15A	3256	Q9UKN7
SCFQSGNKRNHEPFI	KCTD20	81	Q7Z5Y7
KNGSTFICNTHIIPV	KCNH7	101	Q9NS40
HCLGFAPRNSQKVTR	TMEM63C	206	Q9P1W3
TRHIRIHTGQKPFQC	EGR1	356	P18146
SFVRCIVPNHEKRAG	MYH14	691	Q7Z406
NFSIPLCGKRVIHQF	OR14J1	161	Q9UGF5
RQSKAFSNCVPHLIV	OR14K1	231	Q8NGZ2
RFCSQLVKRQHPGVK	NAT16	141	Q8N8M0
PKGHVSSLARCSIVN	ISG20L2	191	Q9H9L3
KVHRNSTIRPGCDVN	KANSL1	616	Q7Z3B3
VVNITCFRHKVNPNV	KDM4C	856	Q9H3R0
CQPAQAFVVKRGVHV	TUBGCP6	371	Q96RT7
PHCNSASTRIFGKQT	LRRC63	111	Q05C16
AQKQCSILHGPTFAA	MUC5AC	1091	P98088
SPCKDINTFIHGNKR	ANG	61	P03950
FHNGVKCLVPEVTFR	EDC3	41	Q96F86
NPAVHFAQVVKECRA	DDX11	601	Q96FC9
HQFCSRSGQPTKKNV	NUDT13	166	Q86X67
IKQLHPSNCLGIRSF	KLHL4	276	Q9C0H6
SPGSQAQKVIICHRG	PTF1A	246	Q7RTS3
SRACSTPHVQVAGKA	ARHGAP6	816	O43182
CFPRLDINVSKGINH	PRIM1	301	P49642
RNILPGLNITCTFHK	P2RX7	206	Q99572
VCTLIHRKAVPGNSA	RGPD3	536	A6NKT7
KLSGHPNIVQFCSAA	GAK	91	O14976
IGNKNAVFHIKTCRP	HYDIN	226	Q4G0P3
NREHCFDGIPITKNV	CORO2B	26	Q9UQ03
NGKFTLVVPHQHRNC	CRHBP	191	P24387
EFGRLHCKFVVQTSP	DNAH3	1896	Q8TD57
KNCHNRVVFSTGPQS	PRMT3	461	O60678
FNSVTNCLGPRKFLH	ITSN1	1451	Q15811
FAHPSKSCQVENGRV	MBNL1	36	Q9NR56
APVIFSHSAARGVCN	DPEP2	276	Q9H4A9
VVTFHCSAKANPAVT	KIRREL3	266	Q8IZU9
HPSRAQFVTCGQDKL	EML2	386	O95834
HAGFQRTPTKQACID	FBN2	561	P35556
QRRFCPSIQGAKIIH	FBXO30	566	Q8TB52
TQAKQGAVLHPTCVF	DHX34	831	Q14147
CIRALGQNKAHTPFR	KIF2C	526	Q99661
FFILSKTNPIRVGCH	CACNA1D	866	Q01668
QQRFRPSVVKDCIHA	DYNLT2B	36	Q8WW35
LKTPNTFAVCTEHRG	KIF1A	1636	Q12756
CRPGEHVTSRFKNEV	MTMR3	151	Q13615
VKTGQCVVFNGTHRT	P2RX6	156	O15547
GDPVSNISQTHFKCR	PRR14L	1366	Q5THK1
VIAKVSGNTHSIFCP	PCARE	1111	A6NGG8
AVCTLIHRKAVPGNS	RGPD1	526	P0DJD0
KVHRTVQQSGQFVVC	JARID2	996	Q92833
LNSCFVKVPRSEGHE	FOXL3	86	A0A1W2PRP0
GICKVHPALNVSTRT	PGGT1B	336	P53609
SAVLCHPKQGQKSVR	RTL9	1236	Q8NET4
FIKTPQQGAQTSLHC	RDH11	256	Q8TC12
VCTLIHRKAVPGNSA	RGPD4	536	Q7Z3J3
GQRSRDVPQKCTLHA	RNF207	146	Q6ZRF8
AQFPRKTITSGIHCA	SLFN14	721	P0C7P3
FVPFGQKCVSHVQVD	TDRD3	91	Q9H7E2
KDPTHGCGNFVRVIQ	SEMA3C	106	Q99985
KHVTATVACQRLGPS	TMEM132C	356	Q8N3T6
VVQCSNFRDKHVPLT	PKDREJ	581	Q9NTG1
QARKIGNITHSIPAC	LAMA1	2846	P25391
NCVKVFTDPSNLQRH	PRDM16	341	Q9HAZ2
KRENFCNIHVSLVPQ	CTPS1	171	P17812
GFQTVKHRNENTCPL	SECISBP2	121	Q96T21
HVKNFRPQCIVLTGG	SLC12A1	676	Q13621
KSVGSPVFVCQANRH	SVEP1	2236	Q4LDE5
HAPKRGQFCIFQLVS	NUP160	361	Q12769
DSGTCSPLRHSFQKQ	ADD1	426	P35611
DPAQFLQVHGRACKV	CLASRP	36	Q8N2M8
NQCPVHFIQHGKLVR	ATP11A	126	P98196
SIACRVHAGPVRQQS	MRPL19	31	P49406
CDRPVKTFQGHTNEV	TBL1X	401	O60907
QQVTLRCSPISGHKS	TRBV5-5	36	A0A597
KRENFCNIHVSLVPQ	CTPS2	171	Q9NRF8
QSPSAGVHTFCDRQK	WDTC1	226	Q8N5D0
FLLPRKCHSSGEVQN	WDTC1	306	Q8N5D0
ECGKAFTQPANFVRH	ZNF599	511	Q96NL3
CQVAPLTHVFQRQKS	TRIM55	156	Q9BYV6
PVAGACHSVKSLQRQ	ZNF324	111	O75467
CHSVKSLQRQRGASP	ZNF324	116	O75467
CARFVELVHQQKTPN	THOC2	996	Q8NI27
HQEKCSFLLRPTQGT	MKRN2OS	56	H3BPM6
TFPRTGKCHVQTIQL	PES1	146	O00541
ISHQQCPGKTSTSFR	STAC2	156	Q6ZMT1
FGKTHPVCNLVASLR	UBE4B	556	O95155
PKIRSHAIACVNQFI	TNPO2	186	O14787
QVTFTHRINFPKKAC	TNR	111	Q92752
QCGETFNRPSKVIQH	ZNF840P	211	A6NDX5
SDPQNGIHCIARKRS	SLC4A5	1116	Q9BY07
KTVVVRCGQRAHPSN	TSPAN11	186	A1L157
PKIRSHAVACVNQFI	TNPO1	196	Q92973
KLVCVSFQRQGFHTV	MRM2	6	Q9UI43
NIAVKVNHSYCSVPG	PIAS4	211	Q8N2W9
KGPVLRNCISTVVHQ	PRKDC	471	P78527
KCFIQPSQFQAHRRI	ZNF234	351	Q14588
SIESPFNHGCVRNII	ZDHHC17	581	Q8IUH5
NVCGKPFAHNSTLRV	ZNF658	941	Q5TYW1
HETVNFSGVKRPFCS	ZMYM2	691	Q9UBW7
VCGKVFGRQQTLSRH	ZNF827	821	Q17R98
PAKRTSAFIQVHCIS	UBP1	176	Q9NZI7
VFRPITTVCQHNVCK	UHRF1	731	Q96T88
RCLGIPNTAHFANVT	SF3A3	436	Q12874
FKVSCNLEPHLRGNV	ZRSR2P1	261	Q15695
IGRGNFKPKQHTVIC	THAP3	41	Q8WTV1
NSFSVVGHLTCQPKI	ZNF529	541	Q6P280
SRPVHQICQNKGSSF	WDR27	701	A2RRH5
FQTSHICKGSALQPQ	nan	36	Q6AWC8
QRLHTGEKPFVCSEN	ZNF367	216	Q7RTV3
GSFQVKIPKNFVCEH	ZNF740	91	Q8NDX6
QANKPSHLCGRVFKV	UBR2	91	Q8IWV8
QKRTSGAVCHQDPRT	RHBDF2	541	Q6PJF5
RCQVKVRSHGQDSPA	TG	1661	P01266
FKVSCNLEPHLRGNV	ZRSR2	256	Q15696
AVVSQHPSRVICKSG	TRBV20-1	16	A0A075B6N2
ATIKQCVVGPNHAAF	UBR5	46	O95071
QVHVKCQHSGSQPFR	ZBTB40	1091	Q9NUA8
NVCGKPFAHNSTLRV	ZNF658B	701	Q4V348
LSGNNIRPVVKVHVC	MYOF	211	Q9NZM1
CGKAFRQRPTLTQHL	MZF1	686	P28698