Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone acetyltransferase activity	CDYL CDY2A CDY1	4.17e-04	51	57	3	GO:0004402
GeneOntologyMolecularFunction	store-operated calcium channel activity	TRPC1 TRPC5	5.19e-04	12	57	2	GO:0015279
GeneOntologyMolecularFunction	peptide-lysine-N-acetyltransferase activity	CDYL CDY2A CDY1	5.21e-04	55	57	3	GO:0061733
GeneOntologyMolecularFunction	peptide N-acetyltransferase activity	CDYL CDY2A CDY1	6.72e-04	60	57	3	GO:0034212
GeneOntologyMolecularFunction	inositol 1,4,5 trisphosphate binding	TRPC1 TRPC5	7.13e-04	14	57	2	GO:0070679
GeneOntologyMolecularFunction	N-acetyltransferase activity	CDYL CDY2A CDY1	1.44e-03	78	57	3	GO:0008080
GeneOntologyMolecularFunction	polypeptide N-acetylgalactosaminyltransferase activity	GALNTL6 GALNT10	1.47e-03	20	57	2	GO:0004653
GeneOntologyMolecularFunction	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	TXNRD1 NCF1	1.47e-03	20	57	2	GO:0050664
GeneOntologyMolecularFunction	carbohydrate binding	GALNTL6 SIGLEC12 GALNT10 ASGR1 CRYBG1	1.89e-03	310	57	5	GO:0030246
GeneOntologyMolecularFunction	methylated histone binding	CDYL MPHOSPH8 CDY1	1.91e-03	86	57	3	GO:0035064
GeneOntologyMolecularFunction	methylation-dependent protein binding	CDYL MPHOSPH8 CDY1	2.04e-03	88	57	3	GO:0140034
GeneOntologyMolecularFunction	N-acyltransferase activity	CDYL CDY2A CDY1	3.10e-03	102	57	3	GO:0016410
GeneOntologyMolecularFunction	acetyltransferase activity	CDYL CDY2A CDY1	3.27e-03	104	57	3	GO:0016407
GeneOntologyMolecularFunction	solute:inorganic anion antiporter activity	SLC4A7 SLC37A3	3.76e-03	32	57	2	GO:0005452
GeneOntologyMolecularFunction	histone modifying activity	CDYL CDY2A JMJD1C CDY1	4.14e-03	229	57	4	GO:0140993
GeneOntologyMolecularFunction	acetylgalactosaminyltransferase activity	GALNTL6 GALNT10	4.48e-03	35	57	2	GO:0008376
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	SLC9A2 SLC4A7 SLC37A3 TRPC1 TRPC5 ANO8 SLC5A3	5.61e-03	758	57	7	GO:0015318
Domain	Chromo	CDYL MPHOSPH8 CDY2A CDY1	1.03e-06	26	56	4	PF00385
Domain	CHROMO_1	CDYL MPHOSPH8 CDY2A CDY1	1.41e-06	28	56	4	PS00598
Domain	CHROMO_2	CDYL MPHOSPH8 CDY2A CDY1	1.41e-06	28	56	4	PS50013
Domain	Chromodomain-like	CDYL MPHOSPH8 CDY2A CDY1	2.45e-06	32	56	4	IPR016197
Domain	Chromo/shadow_dom	CDYL MPHOSPH8 CDY2A CDY1	2.78e-06	33	56	4	IPR000953
Domain	CHROMO	CDYL MPHOSPH8 CDY2A CDY1	2.78e-06	33	56	4	SM00298
Domain	Crotonase_core_superfam	CDYL CDY2A CDY1	1.69e-05	17	56	3	IPR001753
Domain	ECH_1	CDYL CDY2A CDY1	1.69e-05	17	56	3	PF00378
Domain	Ricin_B_lectin	GALNTL6 GALNT10 CRYBG1	5.60e-05	25	56	3	PF00652
Domain	RICIN	GALNTL6 GALNT10 CRYBG1	7.93e-05	28	56	3	SM00458
Domain	RICIN_B_LECTIN	GALNTL6 GALNT10 CRYBG1	7.93e-05	28	56	3	PS50231
Domain	Ricin_B_lectin	GALNTL6 GALNT10 CRYBG1	9.79e-05	30	56	3	IPR000772
Domain	TRP_dom	TRPC1 TRPC5	1.31e-04	6	56	2	IPR013555
Domain	TRP_2	TRPC1 TRPC5	1.31e-04	6	56	2	PF08344
Domain	TRPC_channel	TRPC1 TRPC5	1.84e-04	7	56	2	IPR002153
Domain	Chromo_dom_subgr	CDY2A CDY1	3.91e-04	10	56	2	IPR017984
Domain	TRP_channel	TRPC1 TRPC5	4.77e-04	11	56	2	IPR004729
Domain	Chromodomain_CS	CDYL MPHOSPH8	1.31e-03	18	56	2	IPR023779
Domain	Chromo_domain	CDYL MPHOSPH8	2.34e-03	24	56	2	IPR023780
Domain	Glycos_transf_2	GALNTL6 GALNT10	3.64e-03	30	56	2	PF00535
Domain	Glyco_trans_2-like	GALNTL6 GALNT10	3.64e-03	30	56	2	IPR001173
Domain	-	TRPC1 TRPC5 MPHOSPH8 ACBD6	6.49e-03	248	56	4	1.25.40.20
Domain	ANK	TRPC1 TRPC5 MPHOSPH8 ACBD6	6.77e-03	251	56	4	SM00248
Domain	ANK_REPEAT	TRPC1 TRPC5 MPHOSPH8 ACBD6	6.96e-03	253	56	4	PS50088
Domain	Ankyrin_rpt-contain_dom	TRPC1 TRPC5 MPHOSPH8 ACBD6	7.05e-03	254	56	4	IPR020683
Domain	ANK_REP_REGION	TRPC1 TRPC5 MPHOSPH8 ACBD6	7.05e-03	254	56	4	PS50297
Pubmed	Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome.	CDYL CDY2A CDY1	4.16e-08	5	57	3	10192397
Pubmed	Mammalian chromodomain proteins: their role in genome organisation and expression.	CDYL CDY2A CDY1	2.32e-07	8	57	3	10655032
Pubmed	Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis.	CDYL CDY2A CDY1	2.32e-07	8	57	3	12072557
Pubmed	Interaction of DNA topoisomerase 1 with DNA intermediates and proteins of base excision repair.	PARP1 TOP1	2.64e-06	2	57	2	19916945
Pubmed	Poly(ADP-ribose) polymerase signaling of topoisomerase 1-dependent DNA damage in carcinoma cells.	PARP1 TOP1	2.64e-06	2	57	2	20875401
Pubmed	TRPC1 and TRPC5 form a novel cation channel in mammalian brain.	TRPC1 TRPC5	2.64e-06	2	57	2	11301024
Pubmed	CDYL1 fosters double-strand break-induced transcription silencing and promotes homology-directed repair.	PARP1 CDYL	2.64e-06	2	57	2	29177481
Pubmed	Distribution of TRPC1 and TRPC5 in medial temporal lobe structures of mice.	TRPC1 TRPC5	2.64e-06	2	57	2	16044320
Pubmed	Capacitative Ca2+ entries and mRNA expression for TRPC1 and TRPC5 channels in human epidermoid carcinoma A431 cells.	TRPC1 TRPC5	2.64e-06	2	57	2	15763245
Pubmed	TRPC1 proteins confer PKC and phosphoinositol activation on native heteromeric TRPC1/C5 channels in vascular smooth muscle: comparative study of wild-type and TRPC1-/- mice.	TRPC1 TRPC5	2.64e-06	2	57	2	21968068
Pubmed	Enhanced killing of cancer cells by poly(ADP-ribose) polymerase inhibitors and topoisomerase I inhibitors reflects poisoning of both enzymes.	PARP1 TOP1	2.64e-06	2	57	2	22158865
Pubmed	Mycoplasma fermentans inhibits the activity of cellular DNA topoisomerase I by activation of PARP1 and alters the efficacy of its anti-cancer inhibitor.	PARP1 TOP1	2.64e-06	2	57	2	24013388
Pubmed	A ubiquitin-proteasome pathway for the repair of topoisomerase I-DNA covalent complexes.	PARP1 TOP1	2.64e-06	2	57	2	18515798
Pubmed	The cytosolic entry of diphtheria toxin catalytic domain requires a host cell cytosolic translocation factor complex.	TXNRD1 PARP1	2.64e-06	2	57	2	12668662
Pubmed	TRPC channel activation by extracellular thioredoxin.	TRPC1 TRPC5	2.64e-06	2	57	2	18172497
Pubmed	Poly(ADP-ribosyl)ation as a DNA damage-induced post-translational modification regulating poly(ADP-ribose) polymerase-1-topoisomerase I interaction.	PARP1 TOP1	2.64e-06	2	57	2	15247263
Pubmed	Interrogating the Significance of PARP1 Expression and PBRM1 Mutation as Biomarkers for Predicting the Response to Atezolizumab plus Bevacizumab or to Sunitinib in Patients with Clear Cell Renal Cell Carcinoma.	PARP1 PBRM1	2.64e-06	2	57	2	35688666
Pubmed	Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory.	TRPC1 TRPC5	7.91e-06	3	57	2	28790178
Pubmed	Differential PI(4,5)P2 sensitivities of TRPC4, C5 homomeric and TRPC1/4, C1/5 heteromeric channels.	TRPC1 TRPC5	7.91e-06	3	57	2	30755645
Pubmed	TRPC1/4/5 channels contribute to morphine-induced analgesic tolerance and hyperalgesia by enhancing spinal synaptic potentiation and structural plasticity.	TRPC1 TRPC5	7.91e-06	3	57	2	32359120
Pubmed	Transient receptor potential channel 1 (TRPC1) reduces calcium permeability in heteromeric channel complexes.	TRPC1 TRPC5	7.91e-06	3	57	2	22157757
Pubmed	Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels.	TRPC1 TRPC5	7.91e-06	3	57	2	28325835
Pubmed	Infantile hypertrophic pyloric stenosis: evaluation of three positional candidate genes, TRPC1, TRPC5 and TRPC6, by association analysis and re-sequencing.	TRPC1 TRPC5	7.91e-06	3	57	2	19701773
Pubmed	Transient Receptor Potential C 1/4/5 Is a Determinant of MTI-101 Induced Calcium Influx and Cell Death in Multiple Myeloma.	TRPC1 TRPC5	7.91e-06	3	57	2	34199280
Pubmed	Dual action of the Gαq-PLCβ-PI(4,5)P2 pathway on TRPC1/4 and TRPC1/5 heterotetramers.	TRPC1 TRPC5	7.91e-06	3	57	2	30108272
Pubmed	Genetic mapping of mouse transient receptor potential (Trrp) genes responsible for capacitative calcium entry channels to chromosomes 3, 7, 9, and X.	GUCY2F TRPC1 TRPC5	8.24e-06	24	57	3	9722956
Pubmed	Interaction with dopamine D2 receptor enhances expression of transient receptor potential channel 1 at the cell surface.	TRPC1 TRPC5	1.58e-05	4	57	2	18261457
Pubmed	NMDA receptor-dependent synaptic activation of TRPC channels in olfactory bulb granule cells.	TRPC1 TRPC5	1.58e-05	4	57	2	22539836
Pubmed	SARAF modulates TRPC1, but not TRPC6, channel function in a STIM1-independent manner.	TRPC1 SARAF	1.58e-05	4	57	2	27506849
Pubmed	Constitutively active TRPC channels of adipocytes confer a mechanism for sensing dietary fatty acids and regulating adiponectin.	TRPC1 TRPC5	1.58e-05	4	57	2	22668831
Pubmed	Transient Receptor Potential Canonical 5-Scramblase Signaling Complex Mediates Neuronal Phosphatidylserine Externalization and Apoptosis.	TRPC1 TRPC5	1.58e-05	4	57	2	32110987
Pubmed	Pharmacodynamic genes do not influence risk of neutropenia in cancer patients treated with moderately high-dose irinotecan.	PARP1 TOP1	1.58e-05	4	57	2	19604089
Pubmed	A long-range restriction map of deletion interval 6 of the human Y chromosome: a region frequently deleted in azoospermic males.	CDY2A CDY1	1.58e-05	4	57	2	9806824
Pubmed	Increased frequency of DNA deletions in pink-eyed unstable mice carrying a mutation in the Werner syndrome gene homologue.	PARP1 TOP1	1.58e-05	4	57	2	11756244
Pubmed	The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing.	TRPC1 TRPC5	1.58e-05	4	57	2	26520460
Pubmed	Canonical transient receptor channel 5 (TRPC5) and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms.	TRPC1 TRPC5	1.58e-05	4	57	2	23188715
Pubmed	TRPC1- and TRPC3-dependent Ca2+ signaling in mouse cortical astrocytes affects injury-evoked astrogliosis in vivo.	TRPC1 TRPC5	1.58e-05	4	57	2	28636132
Pubmed	Identification and characterization of the cynomolgus monkey chromodomain gene cynCDY, an orthologue of the human CDY gene family.	CDY2A CDY1	1.58e-05	4	57	2	12149400
Pubmed	Formation of novel TRPC channels by complex subunit interactions in embryonic brain.	TRPC1 TRPC5	2.63e-05	5	57	2	12857742
Pubmed	Enhanced capacitative calcium entry and TRPC channel gene expression in human LES smooth muscle.	TRPC1 TRPC5	2.63e-05	5	57	2	12736151
Pubmed	Store-operated Ca2+ entry and Ca2+ responses to hypothalamic releasing hormones in anterior pituitary cells from Orai1-/- and heptaTRPC knockout mice.	TRPC1 TRPC5	2.63e-05	5	57	2	30452936
Pubmed	Specificity of the chromodomain Y chromosome family of chromodomains for lysine-methylated ARK(S/T) motifs.	CDYL CDY1	2.63e-05	5	57	2	18450745
Pubmed	TRUSS, TNF-R1, and TRPC ion channels synergistically reverse endoplasmic reticulum Ca2+ storage reduction in response to m1 muscarinic acetylcholine receptor signaling.	TRPC1 TRPC5	2.63e-05	5	57	2	20458742
Pubmed	Caspase-9 activation revealed by semaphorin 7A cleavage is independent of apoptosis in the aged olfactory bulb.	PARP1 NCAM1	2.63e-05	5	57	2	19741144
Pubmed	Calcium Channels Formed by Mammalian Trp Homologues.	TRPC1 TRPC5	3.94e-05	6	57	2	11390792
Pubmed	trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry.	TRPC1 TRPC5	3.94e-05	6	57	2	8646775
Pubmed	Axon growth and guidance genes identify nascent, immature, and mature olfactory sensory neurons.	DPYSL3 NCAM1	3.94e-05	6	57	2	20882566
Pubmed	TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation.	TRPC1 TRPC5	3.94e-05	6	57	2	29373286
Pubmed	TRPC channels regulate Ca2+-signaling and short-term plasticity of fast glutamatergic synapses.	TRPC1 TRPC5	3.94e-05	6	57	2	31536487
Pubmed	Transient receptor potential channels and their role in modulating radial glial-neuronal interaction: a signaling pathway involving mGluR5.	TRPC1 TRPC5	3.94e-05	6	57	2	25347706
Pubmed	TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations.	TRPC1 TRPC5	3.94e-05	6	57	2	32414784
Pubmed	Enkurin is a novel calmodulin and TRPC channel binding protein in sperm.	TRPC1 TRPC5	3.94e-05	6	57	2	15385169
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	PARP1 RIOK1 TBRG4 GTF2H2 PBRM1 RTCB PPME1 CRYBG1 CDYL TOP1	5.03e-05	1318	57	10	30463901
Pubmed	MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC.	TRPC1 TRPC5	5.51e-05	7	57	2	15757897
Pubmed	Mechanism of stretch-induced activation of the mechanotransducer zyxin in vascular cells.	TRPC1 TRPC5	5.51e-05	7	57	2	23233529
Pubmed	RNA-seq analysis reveals TRPC genes to impact an unexpected number of metabolic and regulatory pathways.	TRPC1 TRPC5	5.51e-05	7	57	2	32350291
Pubmed	TRPC absence induces pro-inflammatory macrophages and gut microbe disorder, sensitizing mice to colitis.	TRPC1 TRPC5	5.51e-05	7	57	2	36592529
Pubmed	Functional role of TRPC proteins in vivo: lessons from TRPC-deficient mouse models.	TRPC1 TRPC5	5.51e-05	7	57	2	15336983
Pubmed	Taperin (c9orf75), a mutated gene in nonsyndromic deafness, encodes a vertebrate specific, nuclear localized protein phosphatase one alpha (PP1α) docking protein.	PARP1 TOP1	5.51e-05	7	57	2	23213405
Pubmed	TRPC absence induces pro-inflammatory macrophage polarization to promote obesity and exacerbate colorectal cancer.	TRPC1 TRPC5	5.51e-05	7	57	2	38835669
Pubmed	Nuclear receptor coactivator thyroid hormone receptor-binding protein (TRBP) interacts with and stimulates its associated DNA-dependent protein kinase.	PARP1 TOP1	5.51e-05	7	57	2	12519782
Pubmed	Subunit composition, molecular environment, and activation of native TRPC channels encoded by their interactomes.	TRPC1 TRPC5	5.51e-05	7	57	2	36257322
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	PARP1 PBRM1 JADE3 CDYL MPHOSPH8 JMJD1C TOP1	5.98e-05	608	57	7	36089195
Pubmed	Subunit composition of mammalian transient receptor potential channels in living cells.	TRPC1 TRPC5	7.34e-05	8	57	2	12032305
Pubmed	Metabolism regulates the spontaneous firing of substantia nigra pars reticulata neurons via KATP and nonselective cation channels.	TRPC1 TRPC5	7.34e-05	8	57	2	25471572
Pubmed	Association of immunophilins with mammalian TRPC channels.	TRPC1 TRPC5	7.34e-05	8	57	2	15199065
Pubmed	Ku is a novel transcriptional recycling coactivator of the androgen receptor in prostate cancer cells.	PARP1 TOP1	7.34e-05	8	57	2	15640154
Pubmed	Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors.	TRPC1 TRPC5	9.43e-05	9	57	2	14505576
Pubmed	Identification of common binding sites for calmodulin and inositol 1,4,5-trisphosphate receptors on the carboxyl termini of trp channels.	TRPC1 TRPC5	9.43e-05	9	57	2	11290752
Pubmed	Cellular subtype distribution and developmental regulation of TRPC channel members in the mouse dorsal root ganglion.	TRPC1 TRPC5	9.43e-05	9	57	2	17480026
Pubmed	Heterogeneous distribution of TRPC proteins in the embryonic cortex.	TRPC1 TRPC5	1.18e-04	10	57	2	18989690
Pubmed	The leak channel NALCN controls tonic firing and glycolytic sensitivity of substantia nigra pars reticulata neurons.	TRPC1 TRPC5	1.18e-04	10	57	2	27177420
Pubmed	The CDY-related gene family: coordinated evolution in copy number, expression profile and protein sequence.	CDYL CDY1	1.18e-04	10	57	2	12837688
Pubmed	The histone and non-histone methyllysine reader activities of the UHRF1 tandem Tudor domain are dispensable for the propagation of aberrant DNA methylation patterning in cancer cells.	CDYL CDY1	1.44e-04	11	57	2	33097091
Pubmed	Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes.	DPYSL3 SLC4A7 PBRM1 TOP1	1.59e-04	165	57	4	16107646
Pubmed	SOX9 induces and maintains neural stem cells.	PARP1 NCAM1	1.72e-04	12	57	2	20871603
Pubmed	Concordant and opposite roles of DNA-PK and the "facilitator of chromatin transcription" (FACT) in DNA repair, apoptosis and necrosis after cisplatin.	PARP1 TOP1	1.72e-04	12	57	2	21679440
Pubmed	The histone variant mH2A1.1 interferes with transcription by down-regulating PARP-1 enzymatic activity.	PARP1 TOP1	2.03e-04	13	57	2	17158748
Pubmed	Melanopsin signalling in mammalian iris and retina.	TRPC1 TRPC5	2.03e-04	13	57	2	22051675
Pubmed	Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.	PARP1 PBRM1 TOP1	2.20e-04	71	57	3	28319113
Pubmed	Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function.	DPYSL3 DYSF	2.73e-04	15	57	2	26403541
Pubmed	Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping.	PARP1 JMJD1C TOP1	2.91e-04	78	57	3	28611094
Pubmed	Y Chromosome Infertility	CDY2A CDY1	3.12e-04	16	57	2	20301513
Pubmed	Dynamic regulation of sarcoplasmic reticulum Ca(2+) stores by stromal interaction molecule 1 and sarcolipin during muscle differentiation.	TRPC1 TRPC5	3.53e-04	17	57	2	22411552
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	TXNRD1 PARP1 RTCB CCDC174 NCF1 PPME1 JMJD1C TOP1	4.16e-04	1103	57	8	34189442
Pubmed	The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3.	PARP1 TOP1	4.43e-04	19	57	2	20504901
Pubmed	IKK-Mediated Regulation of the COP9 Signalosome via Phosphorylation of CSN5.	TXNRD1 OSBP RTCB PPME1	4.81e-04	221	57	4	31950832
Pubmed	ETO2 coordinates cellular proliferation and differentiation during erythropoiesis.	PARP1 TOP1	4.92e-04	20	57	2	16407974
Pubmed	Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells.	TRPC1 TRPC5	5.43e-04	21	57	2	30270038
Pubmed	Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage.	PARP1 TOP1	5.97e-04	22	57	2	24780295
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	DPYSL3 RIOK1 PBRM1 JADE3 CDYL MPHOSPH8	6.46e-04	645	57	6	25281560
Pubmed	Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter.	GTF2H2 TAF1A	6.53e-04	23	57	2	12393749
Pubmed	Mapping the expression of transient receptor potential channels across murine placental development.	TRPC1 TRPC5	7.12e-04	24	57	2	33884443
Pubmed	Preferred SH3 domain partners of ADAM metalloproteases include shared and ADAM-specific SH3 interactions.	AHI1 NCF1	7.12e-04	24	57	2	25825872
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	PARP1 TBRG4 SLC4A7 PBRM1 NCAM1 SARAF JMJD1C TOP1	7.35e-04	1203	57	8	29180619
Pubmed	Functional coherence of the human Y chromosome.	CDY2A CDY1	7.73e-04	25	57	2	9381176
Pubmed	International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.	TRPC1 TRPC5	7.73e-04	25	57	2	16382100
Pubmed	TRAIP regulates replication fork recovery and progression via PCNA.	PARP1 TOP1	9.02e-04	27	57	2	27462463
Pubmed	An introduction to TRP channels.	TRPC1 TRPC5	9.02e-04	27	57	2	16460286
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	PARP1 PBRM1 RTCB JADE3 CDYL MPHOSPH8 JMJD1C TOP1	1.18e-03	1294	57	8	30804502
GeneFamily	Polypeptide N-acetylgalactosaminyltransferases	GALNTL6 GALNT10	7.16e-04	20	36	2	433
GeneFamily	Solute carriers	SLC9A2 SLC4A7 SLC37A3 SLC27A6 SLC5A3	1.05e-03	395	36	5	752
GeneFamily	Transient receptor potential cation channels	TRPC1 TRPC5	1.41e-03	28	36	2	249
Disease	nicotine dependence (implicated_via_orthology)	TRPC1 TRPC5	2.22e-04	12	55	2	DOID:0050742 (implicated_via_orthology)
Disease	Spermatogenic Failure, Nonobstructive, Y-Linked	CDY2A CDY1	4.03e-04	16	55	2	C1839071
Disease	SPERMATOGENIC FAILURE, Y-LINKED, 2	CDY2A CDY1	4.03e-04	16	55	2	415000
Disease	Spermatogenic failure, Y-linked, 2	CDY2A CDY1	4.03e-04	16	55	2	cv:C1839071
Disease	ST2 protein measurement	SLC9A2 ASGR1	7.00e-04	21	55	2	EFO_0010599
Disease	anterior thigh muscle fat infiltration measurement	EBPL DYSF	1.25e-03	28	55	2	EFO_0020936
Disease	feeling tense measurement	GALNT10 NCAM1	1.74e-03	33	55	2	EFO_0009596
Disease	posterior thigh muscle fat infiltration measurement	EBPL DYSF	1.95e-03	35	55	2	EFO_0020934
Disease	free cholesterol measurement, low density lipoprotein cholesterol measurement	ASGR1 JMJD1C TOP1	2.15e-03	137	55	3	EFO_0004611, EFO_0008591
Disease	Mental Retardation, Psychosocial	PARP1 AHI1 ACBD6	2.24e-03	139	55	3	C0025363
Disease	Profound Mental Retardation	PARP1 AHI1 ACBD6	2.24e-03	139	55	3	C0020796
Disease	Mental deficiency	PARP1 AHI1 ACBD6	2.24e-03	139	55	3	C0917816
Disease	ascending aortic diameter	SLC27A6 NCAM1 JMJD1C	2.29e-03	140	55	3	EFO_0021787
Disease	lactate measurement	GALNTL6 CRYBG1	2.42e-03	39	55	2	EFO_0007745
Disease	coffee consumption measurement, tea consumption measurement	NCAM1 JMJD1C	3.07e-03	44	55	2	EFO_0006781, EFO_0010091
Disease	middle cerebral artery infarction (implicated_via_orthology)	PARP1 NCAM1	3.21e-03	45	55	2	DOID:3525 (implicated_via_orthology)
Disease	myocardial infarction (biomarker_via_orthology)	TXNRD1 SLC27A6 NCAM1	3.34e-03	160	55	3	DOID:5844 (biomarker_via_orthology)
Disease	cryptic phenotype measurement	SLC4A7 SLC27A6	3.49e-03	47	55	2	EFO_0021487

Protein segments in the cluster

Peptide	Gene	Start	Entry
WKWVDGTDYETGFKN	ASGR1	221	P07306
VRWKGYDKQDDTWEP	CDY1	26	Q9Y6F8
VRWKGYDKQDDTWEP	CDY2A	26	Q9Y6F7
FFKDNEDWWYGSIGK	AHI1	1081	Q8N157
EHEYTEFGKWMDGWE	ALLC	36	Q8N6M5
LTEAYEKWREWADGK	DPYSL3	116	Q14195
SFFDFEGKQKWEAWK	ACBD6	86	Q9BR61
EWKRRGAELAYKWGT	ANO8	301	Q9HCE9
EDDKENRYWIFRSWG	PARP1	576	P09874
LAKTEKYWDGWFRGL	PPME1	291	Q9Y570
LWLEGSKEEDAGRYW	LY6G6F	91	Q5SQ64
EFDKWKEQEWTKLYG	DZIP1L	251	Q8IYY4
ERLWEDSAGEKWLYG	PBRM1	981	Q86U86
LEWLARIDWDDDKFY	IGHV2-70D	66	A0A0C4DH43
LFAVDRKWFWELGGY	GALNT10	321	Q86SR1
FDDLEWDKREWVKVY	JMJD1C	61	Q15652
WSFLWGDYKGEEKDR	ISM2	246	Q6H9L7
ERDWYIGLVSDEKWK	PCNX4	1056	Q63HM2
KVFLFKGSGYWQWDE	MMP19	391	Q99542
DGWWVIRKDDVTGYF	NCF1	261	P14598
FEFWSLDVNGGDEWK	FBXO44	91	Q9H4M3
NDIWKYEDDKKEWAG	KLHL41	566	O60662
WKEYGKADARWVYFD	EBPL	81	Q9BY08
IYRGEYWECKEKQDW	OSBP	786	P22059
WDGRKWGELEGDTYD	NSUN4	236	Q96CB9
YWECTDDGEAFGKKW	BSPH1	101	Q075Z2
VRWKGYDSEDDTWEP	CDYL	81	Q9Y232
YEGDWVWLKKFSLGD	GUCY2F	566	P51841
IREWDRGKEFSFGYW	CCDC174	361	Q6PII3
YLLEEGEYRDWKAWG	CRYBG1	1286	Q9Y4K1
WEKKPFSEDVNWGYE	CHGB	571	P05060
DWWSKFFASIGEREK	DYSF	1476	O75923
YLFADTWKEEWEKGV	JADE3	66	Q92613
FYEWLELKSEWQKGA	TBRG4	601	Q969Z0
YKVRWKGYTSDDDTW	MPHOSPH8	76	Q99549
LFAVDRKWFWELGGY	GALNTL6	316	Q49A17
DWDEGVGKLAKGYVW	RIOK1	71	Q9BRS2
VDWSLREGYAWAEDK	RTCB	176	Q9Y3I0
WEGGYERTWEILKED	GTF2H2C;	11	Q6P1K8
YRDGEEYEWKETARW	SLC4A7	121	Q9Y6M7
EYEWKETARWLKFEE	SLC4A7	126	Q9Y6M7
KGWDGYDVQWECKTD	SARAF	86	Q96BY9
QSYAEGWKEGTWEEK	POFUT2	141	Q9Y2G5
YFWAKSDWKEDTALA	TAF1A	386	Q15573
GWWDGKKEFDFAAAY	SCRN3	211	Q0VDG4
KETDDGGRYWKFIDW	SLC5A3	646	P53794
VYGSWFKEGADIPWD	SIGLEC12	186	Q96PQ1
GEEVWHSKWYDAKEA	NCAM1	551	P13591
WSDIKRLWYEGLEDF	TRPC1	436	P48995
YGWKVEETVKHDWDR	TXNRD1	236	Q16881
FGWKEAEADKLSIWY	SLC37A3	321	Q8NCC5
WGHNFWRDKFKKFDD	SLC9A2	521	Q9UBY0
WEGGYERTWEILKED	GTF2H2	11	Q13888
WGEIKEMWDGGFTEY	TRPC5	416	Q9UL62
EKWEKYWNEYGGGLL	TGS1	196	Q96RS0
KPDVAVYDGSWSEWF	TST	266	Q16762
FWDRTGDTFRWKGEN	SLC27A6	476	Q9Y2P4
WEEERYPEGIKWKFL	TOP1	206	P11387
YFSELEWGKLEDWQK	ZNF783	151	Q6ZMS7