Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	GTPase activator activity	STARD13 TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B ARHGEF10L CAVIN4 ARFGAP1 TBC1D3I TBC1D3G ARAP1 ARHGAP19 TBC1D3F	8.77e-10	279	137	15	GO:0005096
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	STARD13 GBF1 TBC1D3 TBC1D3H TBC1D3L TBC1D3D ARHGEF5 TBC1D3C TBC1D3B ARHGEF10L CAVIN4 ARFGAP1 TBC1D3I TBC1D3G ARAP1 ARHGAP19 TBC1D3F	7.37e-08	507	137	17	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	STARD13 GBF1 TBC1D3 TBC1D3H TBC1D3L TBC1D3D ARHGEF5 TBC1D3C TBC1D3B ARHGEF10L CAVIN4 ARFGAP1 TBC1D3I TBC1D3G ARAP1 ARHGAP19 TBC1D3F	7.37e-08	507	137	17	GO:0030695
GeneOntologyMolecularFunction	enzyme activator activity	STARD13 TBC1D3 TBC1D3H TBC1D3L TBC1D3D CASP1 CLPX TBC1D3C TBC1D3B ARHGEF10L CAVIN4 ARFGAP1 TBC1D3I TBC1D3G ARAP1 ARHGAP19 TBC1D3F	2.65e-06	656	137	17	GO:0008047
GeneOntologyMolecularFunction	enzyme regulator activity	STARD13 WBP11 GBF1 TBC1D3 TBC1D3H TBC1D3L TBC1D3D ANXA2 ARHGEF5 ANXA2P2 CASP1 CLPX TBC1D3C TBC1D3B ARHGEF10L CAVIN4 WASH3P SERPINI2 ARFGAP1 TBC1D3I QARS1 TBC1D3G ARAP1 ARHGAP19 TBC1D3F	1.11e-05	1418	137	25	GO:0030234
GeneOntologyMolecularFunction	molecular function activator activity	STARD13 TBC1D3 TBC1D3H TBC1D3L TBC1D3D WNT8B GDF6 CASP1 CLPX TBC1D3C TBC1D3B ARHGEF10L IFNB1 CAVIN4 ARFGAP1 TAC1 TBC1D3I TBC1D3G ARAP1 ARHGAP19 TBC1D3F MYBPC3	3.38e-05	1233	137	22	GO:0140677
GeneOntologyMolecularFunction	bone sialoprotein binding	ANXA2 ANXA2P2	4.67e-05	2	137	2	GO:0044730
GeneOntologyMolecularFunction	cadherin binding involved in cell-cell adhesion	ANXA2 PAK4 CDH9	2.82e-04	19	137	3	GO:0098641
GeneOntologyMolecularFunction	G protein-coupled serotonin receptor binding	GNAI1 GNAI3	4.61e-04	5	137	2	GO:0031821
GeneOntologyMolecularFunction	phospholipase A2 inhibitor activity	ANXA2 ANXA2P2	4.61e-04	5	137	2	GO:0019834
GeneOntologyMolecularFunction	protein domain specific binding	CUL3 WBP11 CASP1 GRIA1 OPRM1 KHDRBS3 KHDRBS1 SYNJ2 TJP1 RBMX SCN2A TJP2 GNAI3 SDC2 HCLS1	9.99e-04	875	137	15	GO:0019904
GeneOntologyBiologicalProcess	activation of GTPase activity	TBC1D3 TBC1D3H TBC1D3L TBC1D3D ARHGEF5 TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3F	2.72e-09	109	136	10	GO:0090630
GeneOntologyBiologicalProcess	positive regulation of GTPase activity	TBC1D3 TBC1D3H TBC1D3L TBC1D3D ARHGEF5 TBC1D3C TBC1D3B TBC1D3I TBC1D3G ARAP1 TBC1D3F	6.73e-07	244	136	11	GO:0043547
GeneOntologyBiologicalProcess	positive regulation of hydrolase activity	TBC1D3 TBC1D3H TBC1D3L TBC1D3D RPS3 ARHGEF5 CASP1 NCSTN TBC1D3C TBC1D3B TBC1D3I TBC1D3G ARAP1 TBC1D3F	5.63e-06	499	136	14	GO:0051345
GeneOntologyBiologicalProcess	regulation of GTPase activity	TBC1D3 TBC1D3H TBC1D3L TBC1D3D ARHGEF5 TBC1D3C TBC1D3B TBC1D3I TBC1D3G ARAP1 TBC1D3F	1.41e-05	335	136	11	GO:0043087
GeneOntologyBiologicalProcess	stress fiber assembly	CUL3 ARHGEF5 SYNPO2L ARHGEF10L TJP1 TAC1 ARAP1	2.15e-05	127	136	7	GO:0043149
GeneOntologyBiologicalProcess	contractile actin filament bundle assembly	CUL3 ARHGEF5 SYNPO2L ARHGEF10L TJP1 TAC1 ARAP1	2.15e-05	127	136	7	GO:0030038
GeneOntologyBiologicalProcess	actomyosin structure organization	CUL3 ARHGEF5 SYNPO2L ARHGEF10L CAVIN4 TJP1 TAC1 ARAP1 MYBPC3	3.03e-05	239	136	9	GO:0031032
GeneOntologyBiologicalProcess	regulation of blood-brain barrier permeability	IFNB1 TJP1 TJP2	3.25e-05	10	136	3	GO:1905603
GeneOntologyBiologicalProcess	positive regulation of low-density lipoprotein particle receptor binding	ANXA2 ANXA2P2	4.32e-05	2	136	2	GO:1905597
GeneOntologyBiologicalProcess	regulation of receptor recycling	ANXA2 ANXA2P2 GRIA1 ARAP1	4.96e-05	31	136	4	GO:0001919
GeneOntologyBiologicalProcess	regulation of stress fiber assembly	ARHGEF5 SYNPO2L ARHGEF10L TJP1 TAC1 ARAP1	7.70e-05	107	136	6	GO:0051492
GeneOntologyBiologicalProcess	positive regulation of receptor-mediated endocytosis involved in cholesterol transport	ANXA2 ANXA2P2	1.29e-04	3	136	2	GO:1905602
GeneOntologyBiologicalProcess	negative regulation of low-density lipoprotein particle receptor catabolic process	ANXA2 ANXA2P2	1.29e-04	3	136	2	GO:0032804
GeneOntologyBiologicalProcess	regulation of supramolecular fiber organization	RPS3 SGK1 ARHGEF5 SYNPO2L ARHGEF10L WASH3P TJP1 TAC1 CTNNA2 HCLS1 ARAP1	1.58e-04	438	136	11	GO:1902903
GeneOntologyBiologicalProcess	regulation of actomyosin structure organization	ARHGEF5 SYNPO2L ARHGEF10L TJP1 TAC1 ARAP1	1.59e-04	122	136	6	GO:0110020
GeneOntologyBiologicalProcess	regulation of actin filament bundle assembly	ARHGEF5 SYNPO2L ARHGEF10L TJP1 TAC1 ARAP1	1.66e-04	123	136	6	GO:0032231
GeneOntologyBiologicalProcess	regulation of actin filament organization	ARHGEF5 SYNPO2L ARHGEF10L WASH3P TJP1 TAC1 CTNNA2 HCLS1 ARAP1	1.72e-04	300	136	9	GO:0110053
GeneOntologyBiologicalProcess	cellular response to organic cyclic compound	ZNF366 SGK1 PAK4 CGAS GRIA1 NCSTN OPRM1 IFNB1 KMT2D RORA GNAI1 GNAI3 CTNNA1	1.87e-04	605	136	13	GO:0071407
GeneOntologyBiologicalProcess	receptor metabolic process	GPRASP1 ANXA2 ANXA2P2 GRIA1 ARAP1	2.10e-04	82	136	5	GO:0043112
GeneOntologyBiologicalProcess	positive regulation of receptor recycling	ANXA2 ANXA2P2 ARAP1	2.13e-04	18	136	3	GO:0001921
GeneOntologyBiologicalProcess	positive regulation of low-density lipoprotein particle clearance	ANXA2 ANXA2P2	2.57e-04	4	136	2	GO:1905581
GeneOntologyBiologicalProcess	negative regulation of receptor catabolic process	ANXA2 ANXA2P2	2.57e-04	4	136	2	GO:2000645
GeneOntologyBiologicalProcess	positive regulation of intracellular cholesterol transport	ANXA2 ANXA2P2	2.57e-04	4	136	2	GO:0032385
GeneOntologyBiologicalProcess	positive regulation of intracellular sterol transport	ANXA2 ANXA2P2	2.57e-04	4	136	2	GO:0032382
GeneOntologyBiologicalProcess	actin filament bundle assembly	CUL3 ARHGEF5 SYNPO2L ARHGEF10L TJP1 TAC1 ARAP1	2.79e-04	191	136	7	GO:0051017
GeneOntologyBiologicalProcess	actin filament bundle organization	CUL3 ARHGEF5 SYNPO2L ARHGEF10L TJP1 TAC1 ARAP1	3.17e-04	195	136	7	GO:0061572
GeneOntologyBiologicalProcess	regulation of small GTPase mediated signal transduction	STARD13 CUL3 GBF1 ARHGEF5 SYNPO2L ARHGEF10L ARFGAP1 ARAP1 ARHGAP19	3.72e-04	333	136	9	GO:0051056
GeneOntologyBiologicalProcess	positive regulation of blood-brain barrier permeability	TJP1 TJP2	4.26e-04	5	136	2	GO:1905605
GeneOntologyBiologicalProcess	positive regulation of plasma membrane repair	ANXA2 ANXA2P2	4.26e-04	5	136	2	GO:1905686
GeneOntologyBiologicalProcess	regulation of low-density lipoprotein particle receptor binding	ANXA2 ANXA2P2	4.26e-04	5	136	2	GO:1905595
GeneOntologyBiologicalProcess	positive regulation of intracellular lipid transport	ANXA2 ANXA2P2	4.26e-04	5	136	2	GO:0032379
GeneOntologyBiologicalProcess	regulation of cytoskeleton organization	RPS3 SGK1 ARHGEF5 SYNPO2L ARHGEF10L WASH3P TJP1 TAC1 GNAI1 CTNNA2 HCLS1 ARAP1	4.60e-04	579	136	12	GO:0051493
GeneOntologyBiologicalProcess	receptor recycling	ANXA2 ANXA2P2 GRIA1 ARAP1	4.75e-04	55	136	4	GO:0001881
GeneOntologyBiologicalProcess	supramolecular fiber organization	CUL3 RPS3 ANXA2 SGK1 ARHGEF5 ANXA2P2 SYNPO2L ARHGEF10L CAVIN4 WASH3P TJP1 TAC1 CTNNA2 HCLS1 ARAP1 MYBPC3	5.76e-04	957	136	16	GO:0097435
GeneOntologyBiologicalProcess	positive regulation of stress fiber assembly	ARHGEF5 SYNPO2L ARHGEF10L TAC1	6.21e-04	59	136	4	GO:0051496
GeneOntologyBiologicalProcess	positive regulation of low-density lipoprotein receptor activity	ANXA2 ANXA2P2	6.36e-04	6	136	2	GO:1905599
GeneOntologyBiologicalProcess	regulation of actin filament-based process	ARHGEF5 SYNPO2L ARHGEF10L WASH3P TJP1 TAC1 CTNNA2 HCLS1 ARAP1 MYBPC3	6.63e-04	438	136	10	GO:0032970
GeneOntologyBiologicalProcess	regulation of hydrolase activity	TBC1D3 TBC1D3H TBC1D3L TBC1D3D RPS3 ARHGEF5 CASP1 NCSTN TBC1D3C TBC1D3B SERPINI2 TBC1D3I TBC1D3G ARAP1 TBC1D3F	6.91e-04	878	136	15	GO:0051336
GeneOntologyCellularComponent	AnxA2-p11 complex	ANXA2 ANXA2P2	1.29e-04	3	138	2	GO:1990665
GeneOntologyCellularComponent	PCSK9-AnxA2 complex	ANXA2 ANXA2P2	1.29e-04	3	138	2	GO:1990667
GeneOntologyCellularComponent	supraspliceosomal complex	RBMXL1 RBMX	2.57e-04	4	138	2	GO:0044530
GeneOntologyCellularComponent	cell leading edge	GBF1 RPS3 ANXA2 ANXA2P2 GRIA1 OPRM1 WASH3P SYNJ2 NHS CTNNA1 CTNNA2	4.93e-04	500	138	11	GO:0031252
GeneOntologyCellularComponent	adherens junction	ANXA2 PAK4 TJP1 TJP2 CTNNA1 CTNNA2 CDH9	5.27e-04	212	138	7	GO:0005912
GeneOntologyCellularComponent	plasma membrane protein complex	ANXA2 ANXA2P2 EVC GRIA1 NCSTN ITGAL KHDRBS1 SCN2A GNAI1 GNAI3 CTNNA1 CTNNA2 C8A CDH9	7.04e-04	785	138	14	GO:0098797
GeneOntologyCellularComponent	anchoring junction	RPS3 ANXA2 ARHGEF5 PAK4 GRIA1 NCSTN ITGAL PPIA OPRM1 TJP1 SCN2A TJP2 NHS CTNNA1 CTNNA2 CDH9	7.24e-04	976	138	16	GO:0070161
GeneOntologyCellularComponent	myelin sheath adaxonal region	ANXA2 ANXA2P2	8.89e-04	7	138	2	GO:0035749
Domain	TBC	TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3F	2.00e-09	49	134	8	SM00164
Domain	RabGAP-TBC	TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3F	3.84e-09	53	134	8	PF00566
Domain	Rab-GTPase-TBC_dom	TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3F	5.22e-09	55	134	8	IPR000195
Domain	TBC_RABGAP	TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3F	5.22e-09	55	134	8	PS50086
Domain	RBM1CTR	RBMXL1 RBMXL2 RBMX	1.97e-05	8	134	3	PF08081
Domain	RBM1CTR	RBMXL1 RBMXL2 RBMX	1.97e-05	8	134	3	IPR012604
Domain	Qua1_dom	KHDRBS3 KHDRBS1	1.53e-04	3	134	2	IPR032571
Domain	Sam68-YY	KHDRBS3 KHDRBS1	1.53e-04	3	134	2	IPR032335
Domain	ZO	TJP1 TJP2	1.53e-04	3	134	2	IPR005417
Domain	Sam68-YY	KHDRBS3 KHDRBS1	1.53e-04	3	134	2	PF16568
Domain	Qua1	KHDRBS3 KHDRBS1	1.53e-04	3	134	2	PF16274
Domain	Post-SET_dom	KMT2B SETD2 KMT2D	1.89e-04	16	134	3	IPR003616
Domain	PostSET	KMT2B SETD2 KMT2D	1.89e-04	16	134	3	SM00508
Domain	POST_SET	KMT2B SETD2 KMT2D	1.89e-04	16	134	3	PS50868
Domain	Alpha_catenin	CTNNA1 CTNNA2	3.04e-04	4	134	2	IPR001033
Domain	VINCULIN_1	CTNNA1 CTNNA2	3.04e-04	4	134	2	PS00663
Domain	Vinculin_CS	CTNNA1 CTNNA2	3.04e-04	4	134	2	IPR000633
Domain	FYrich_C	KMT2B KMT2D	5.04e-04	5	134	2	IPR003889
Domain	FYrich_N	KMT2B KMT2D	5.04e-04	5	134	2	IPR003888
Domain	FYRC	KMT2B KMT2D	5.04e-04	5	134	2	SM00542
Domain	FYRN	KMT2B KMT2D	5.04e-04	5	134	2	SM00541
Domain	Vinculin	CTNNA1 CTNNA2	5.04e-04	5	134	2	PF01044
Domain	FYRN	KMT2B KMT2D	5.04e-04	5	134	2	PF05964
Domain	FYRC	KMT2B KMT2D	5.04e-04	5	134	2	PF05965
Domain	FYRC	KMT2B KMT2D	5.04e-04	5	134	2	PS51543
Domain	FYRN	KMT2B KMT2D	5.04e-04	5	134	2	PS51542
Domain	RRM_1	RBMXL1 RBMXL2 RBMX	5.76e-04	23	134	3	SM00361
Domain	RRM_dom_euk	RBMXL1 RBMXL2 RBMX	5.76e-04	23	134	3	IPR003954
Domain	zf-CW	MORC1 KDM1B	1.05e-03	7	134	2	PF07496
Domain	ZF_CW	MORC1 KDM1B	1.05e-03	7	134	2	PS51050
Domain	Vinculin/catenin	CTNNA1 CTNNA2	1.05e-03	7	134	2	IPR006077
Domain	Znf_CW	MORC1 KDM1B	1.05e-03	7	134	2	IPR011124
Domain	Gprotein_alpha_I	GNAI1 GNAI3	1.39e-03	8	134	2	IPR001408
Pathway	WP_17Q12_COPY_NUMBER_VARIATION_SYNDROME	TBC1D3 TBC1D3H TBC1D3L SLFN12 TBC1D3C TBC1D3B TBC1D3I TBC1D3G	8.78e-07	99	108	8	M46448
Pathway	KEGG_TIGHT_JUNCTION	MYL5 TJP1 TJP2 GNAI1 GNAI3 CTNNA1 CTNNA2 HCLS1	7.67e-06	132	108	8	M11355
Pathway	BIOCARTA_ARAP_PATHWAY	GBF1 ARFGAP1 ARAP1	9.15e-05	12	108	3	MM1342
Pubmed	TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12.	TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3F	1.09e-20	11	139	9	16863688
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	WBP11 RBMXL1 RPS3 ANXA2 CHD9 CHD4 GPATCH8 PPIA SDAD1 MYEF2 POLR1D SETD2 NOP14 KHDRBS3 KHDRBS1 FAM32A MRPL16 TJP1 RBMX CSTF3 MACROH2A2 KDM1B SNRNP200 KPNA3	9.26e-12	1082	139	24	38697112
Pubmed	DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.	TBC1D3 TBC1D3H TBC1D3D SEPTIN4 TBC1D3B TBC1D3G TBC1D3F	2.01e-08	74	139	7	16625196
Pubmed	BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.	GBF1 KMT2B RBMXL1 RPS3 IARS1 CHD4 EDC4 SDAD1 KMT2D KHDRBS1 RBMX ARFGAP1 TJP2 GNAI3 CTNNA1 SNRNP200	2.90e-08	711	139	16	33022573
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	HEXB CUL3 OXR1 SEPTIN5 SEPTIN4 RPS3 ANXA2 IARS1 ANXA2P2 GRIA1 EDC4 MYEF2 KHDRBS1 TJP1 RBMX SCN2A TJP2 GNAI1 CTNNA1 CTNNA2 SNRNP200 KPNA3	6.01e-08	1431	139	22	37142655
Pubmed	A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling.	HEXB WBP11 ANXA2 IARS1 CHD4 EDC4 ECHS1 PPIA RBMXL2 TJP1 CSTF3 AK2 MACROH2A2 GNAI1 CTNNA1 QARS1	1.14e-07	786	139	16	29128334
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	WBP11 RPS3 ANXA2 IARS1 CHD4 EDC4 ECHS1 PPIA MYEF2 KHDRBS1 TJP1 RBMX TJP2 CSTF3 MACROH2A2 CTNNA1 QARS1 SNRNP200	1.55e-07	1024	139	18	24711643
Pubmed	RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing.	RBMXL2 KHDRBS3 KHDRBS1 RBMX	1.70e-07	13	139	4	10749975
Pubmed	Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin.	TJP1 TJP2 CTNNA1	2.49e-07	4	139	3	10026224
Pubmed	PRC17, a novel oncogene encoding a Rab GTPase-activating protein, is amplified in prostate cancer.	TBC1D3 TBC1D3D TBC1D3F	2.49e-07	4	139	3	12359748
Pubmed	Disruption of the nuclear hormone receptor RORalpha in staggerer mice.	ANXA2 ANXA2P2 RORA	2.49e-07	4	139	3	8602221
Pubmed	Identification of novel sequences in the repertoire of hypervariable TRE17 genes from immortalized nonmalignant and malignant human keratinocytes.	TBC1D3 TBC1D3D TBC1D3F	2.49e-07	4	139	3	8406013
Pubmed	Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.	WBP11 RBMXL1 RPS3 ANXA2 IARS1 CHD4 PPIA MYEF2 NOP14 KHDRBS3 RBMX MRPS5 MACROH2A2 SNRNP200 KPNA3	2.63e-07	731	139	15	29298432
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	CYLC1 STARD13 WBP11 RBMXL1 ANXA2 DZIP1L DNAH2 GRIA1 CHD4 CLPX GPR101 ATP6V1G3 RBMXL2 NOP14 KHDRBS3 KHDRBS1 TJP1 RBMX GNAI1 GNAI3 HCLS1	3.03e-07	1442	139	21	35575683
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	KMT2B RPS3 IARS1 CHD4 SDAD1 NOP14 KHDRBS1 TJP1 RBMX JRK TJP2 CSTF3 MRPS5 GNAI1 QARS1 SNRNP200	3.10e-07	847	139	16	35850772
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	CUL3 IARS1 VPS13C DNAH2 CHD4 EDC4 PPIA SETD2 KHDRBS1 RBMX JRK SV2C AK2 SNRNP200 HCLS1	3.89e-07	754	139	15	35906200
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	CUL3 GBF1 KMT2B RPS3 TATDN2 CHD4 GPATCH8 SETD2 KMT2D RBMXL2 RBMX ARFGAP1 TJP2 CTNNA1 SNRNP200	5.40e-07	774	139	15	15302935
Pubmed	The Tre2 (USP6) oncogene is a hominoid-specific gene.	TBC1D3 TBC1D3D TBC1D3C	6.21e-07	5	139	3	12604796
Pubmed	Human TRE17 oncogene is generated from a family of homologous polymorphic sequences by single-base changes.	TBC1D3 TBC1D3D TBC1D3F	6.21e-07	5	139	3	8471161
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	CUL3 RBMXL1 RPS3 ANXA2 IARS1 CGAS EDC4 PPIA SDAD1 NOP14 KHDRBS1 TJP1 RBMX TJP2 GNAI1 GNAI3 CTNNA1 QARS1 SNRNP200	6.79e-07	1257	139	19	36526897
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	CUL3 RPS3 ANXA2 IARS1 CHD9 CHD4 EDC4 PPIA KIFAP3 KHDRBS1 RBMX MRPS5 CTNNA1 QARS1 SNRNP200	9.38e-07	809	139	15	32129710
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	CUL3 GBF1 RAD21L1 PPIA FCHO1 SERPINI2 KHDRBS1 RBMX TJP2 MTBP	2.09e-06	361	139	10	26167880
Pubmed	The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin.	TJP1 CTNNA1 CTNNA2	2.16e-06	7	139	3	12808048
Pubmed	The STAR/GSG family protein rSLM-2 regulates the selection of alternative splice sites.	KHDRBS3 KHDRBS1 RBMX	2.16e-06	7	139	3	11118435
Pubmed	Adhesion protein VSIG1 is required for the proper differentiation of glandular gastric epithelia.	TJP1 CTNNA1 CTNNA2	2.16e-06	7	139	3	21991385
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	WBP11 GBF1 PDPR ANXA2 IARS1 CHD4 CLPX ECHS1 KHDRBS1 TJP1 RBMX ARFGAP1 TJP2 CSTF3 GNAI1 GNAI3 CTNNA1 ATL2 QARS1	2.33e-06	1367	139	19	32687490
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	MAGEB2 WBP11 RPS3 ANXA2 CHD4 GPATCH8 PPIA SDAD1 NOP14 KHDRBS1 RBMX ARFGAP1 MRPS5 ATL2 QARS1 SNRNP200	2.34e-06	989	139	16	36424410
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	GPRASP1 HK2 SEPTIN5 ANXA2 IARS1 ANXA2P2 GRIA1 EDC4 ECHS1 PPIA NACAD MYEF2 TJP1 ARFGAP1 TJP2 MRPS5 CTNNA2	3.26e-06	1139	139	17	36417873
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	IFT140 GBF1 TATDN2 CLPX LPIN1 KHDRBS3 KHDRBS1 RBMX	4.62e-06	232	139	8	25515538
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	STARD13 RPS3 ANXA2 IARS1 CHD4 EDC4 ECHS1 PPIA MYEF2 KHDRBS1 AK2 CTNNA1 QARS1 SNRNP200	4.73e-06	807	139	14	30575818
Pubmed	Inhibitory G proteins play multiple roles to polarize sensory hair cell morphogenesis.	TJP1 GNAI1 GNAI3	5.16e-06	9	139	3	38651641
Pubmed	Characterization of gene regulation and protein interaction networks for Matrin 3 encoding mutations linked to amyotrophic lateral sclerosis and myopathy.	RBMXL1 IARS1 MYEF2 KHDRBS1 RBMX SNRNP200	5.28e-06	109	139	6	29511296
Pubmed	A global genomic transcriptional code associated with CNS-expressed genes.	OXR1 RBMXL1 ANXA2 SGK1 ANXA2P2 WNT8B EFHB RBMX RORA	5.78e-06	318	139	9	16919269
Pubmed	The LGN protein promotes planar proliferative divisions in the neocortex but apicobasal asymmetric terminal divisions in the retina.	TJP1 GNAI1 GNAI3	7.34e-06	10	139	3	26755700
Pubmed	T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis.	KHDRBS3 KHDRBS1 RBMX	7.34e-06	10	139	3	10332027
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	CUL3 WBP11 KMT2B IARS1 CASP1 CHD9 CHD4 EDC4 POLR1D KMT2D NOP14 KHDRBS1 FAM32A RBMX CSTF3 SNRNP200	9.24e-06	1103	139	16	34189442
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CUL3 IFT140 PDPR VPS13C PAK4 NCSTN NACAD MYEF2 ARHGEF10L SYNJ2 ARAP1	9.86e-06	529	139	11	14621295
Pubmed	Scrib is required for epithelial cell identity and prevents epithelial to mesenchymal transition in the mouse.	TJP1 CTNNA1 CTNNA2	1.01e-05	11	139	3	24095903
Pubmed	Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.	HK2 RPS3 ANXA2 IARS1 NOP14 KHDRBS1 RBMX GNAI3 CFAP57 QARS1 SNRNP200 KPNA3	1.10e-05	641	139	12	36057605
Pubmed	Delineating the HMGB1 and HMGB2 interactome in prostate and ovary epithelial cells and its relationship with cancer.	RPS3 ANXA2 TJP1 RBMX TJP2 MACROH2A2 SNRNP200	1.13e-05	188	139	7	29721183
Pubmed	Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer.	RPS3 VPS13C KMT2D TJP1 GNAI1 GNAI3 CTNNA1 SNRNP200	1.18e-05	264	139	8	32814769
Pubmed	Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation.	RPS3 IARS1 CHD4 NOP14 KHDRBS1 RBMX MRPS5 QARS1 SNRNP200 KPNA3	1.21e-05	441	139	10	31239290
Pubmed	Synergistic action of nectins and cadherins generates the mosaic cellular pattern of the olfactory epithelium.	TJP1 CTNNA1 CTNNA2	1.34e-05	12	139	3	26929452
Pubmed	Identification of two keratinocyte stem cell regulatory loci implicated in skin carcinogenesis.	ANXA2 ANXA2P2 RORA	1.34e-05	12	139	3	12663500
Pubmed	Vascular endothelial growth factor upregulates expression of annexin A2 in vitro and in a mouse model of ischemic retinopathy.	ANXA2 ANXA2P2	1.59e-05	2	139	2	19536308
Pubmed	The zonula occludens protein family regulates the hepatic barrier system in the murine liver.	TJP1 TJP2	1.59e-05	2	139	2	33184034
Pubmed	Annexin A2 modulates radiation-sensitive transcriptional programming and cell fate.	ANXA2 ANXA2P2	1.59e-05	2	139	2	23148505
Pubmed	ANXA2 (annexin A2) is crucial to ATG7-mediated autophagy, leading to tumor aggressiveness in triple-negative breast cancer cells.	ANXA2 ANXA2P2	1.59e-05	2	139	2	38290972
Pubmed	ZO-1- and ZO-2-dependent integration of myosin-2 to epithelial zonula adherens.	TJP1 TJP2	1.59e-05	2	139	2	18596233
Pubmed	The cDNA sequence for the protein-tyrosine kinase substrate p36 (calpactin I heavy chain) reveals a multidomain protein with internal repeats.	ANXA2 ANXA2P2	1.59e-05	2	139	2	3013423
Pubmed	Activation of Annexin A2 signaling at the blood-brain barrier in a mouse model of multiple sclerosis.	ANXA2 ANXA2P2	1.59e-05	2	139	2	35064931
Pubmed	Complex Roles of Annexin A2 in Host Blood-Brain Barrier Invasion by Cryptococcus neoformans.	ANXA2 ANXA2P2	1.59e-05	2	139	2	28130864
Pubmed	Kabuki syndrome stem cell models reveal locus specificity of histone methyltransferase 2D (KMT2D/MLL4).	KMT2B KMT2D	1.59e-05	2	139	2	35640156
Pubmed	Localization of annexin II in the paranodal regions and Schmidt-Lanterman incisures in the peripheral nervous system.	ANXA2 ANXA2P2	1.59e-05	2	139	2	17549680
Pubmed	Annexin A2 promotes proliferative vitreoretinopathy in response to a macrophage inflammatory signal in mice.	ANXA2 ANXA2P2	1.59e-05	2	139	2	39384746
Pubmed	Structure of the µ-opioid receptor-Gi protein complex.	OPRM1 GNAI1	1.59e-05	2	139	2	29899455
Pubmed	Annexin A2 mediates up-regulation of NF-κB, β-catenin, and stem cell in response to progastrin in mice and HEK-293 cells.	ANXA2 ANXA2P2	1.59e-05	2	139	2	20826156
Pubmed	ZO-1 and ZO-2 independently determine where claudins are polymerized in tight-junction strand formation.	TJP1 TJP2	1.59e-05	2	139	2	16923393
Pubmed	Prohibitin/annexin 2 interaction regulates fatty acid transport in adipose tissue.	ANXA2 ANXA2P2	1.59e-05	2	139	2	27468426
Pubmed	Homocysteine inhibits neoangiogenesis in mice through blockade of annexin A2-dependent fibrinolysis.	ANXA2 ANXA2P2	1.59e-05	2	139	2	19841537
Pubmed	ZO-1 and ZO-2 are required for extra-embryonic endoderm integrity, primitive ectoderm survival and normal cavitation in embryoid bodies derived from mouse embryonic stem cells.	TJP1 TJP2	1.59e-05	2	139	2	24905925
Pubmed	Annexin A2 Modulates ROS and Impacts Inflammatory Response via IL-17 Signaling in Polymicrobial Sepsis Mice.	ANXA2 ANXA2P2	1.59e-05	2	139	2	27389701
Pubmed	Structural basis of RNA recognition and dimerization by the STAR proteins T-STAR and Sam68.	KHDRBS3 KHDRBS1	1.59e-05	2	139	2	26758068
Pubmed	Annexin II expressed by osteoblasts and endothelial cells regulates stem cell adhesion, homing, and engraftment following transplantation.	ANXA2 ANXA2P2	1.59e-05	2	139	2	17360942
Pubmed	Annexin A2 regulates phagocytosis of photoreceptor outer segments in the mouse retina.	ANXA2 ANXA2P2	1.59e-05	2	139	2	19587120
Pubmed	Annexin A2 at the interface between F-actin and membranes enriched in phosphatidylinositol 4,5,-bisphosphate.	ANXA2 ANXA2P2	1.59e-05	2	139	2	19022301
Pubmed	Interferon-beta counteracts inflammatory mediator-induced effects on brain endothelial cell tight junction molecules-implications for multiple sclerosis.	TJP1 TJP2	1.59e-05	2	139	2	12152786
Pubmed	Sensation of abdominal pain induced by peritoneal carcinomatosis is accompanied by changes in the expression of substance P and μ-opioid receptors in the spinal cord of mice.	OPRM1 TAC1	1.59e-05	2	139	2	22913923
Pubmed	Multi-Omics Profiling Identifies Microglial Annexin A2 as a Key Mediator of NF-κB Pro-inflammatory Signaling in Ischemic Reperfusion Injury.	ANXA2 ANXA2P2	1.59e-05	2	139	2	38253182
Pubmed	Requirement of Gαi1 and Gαi3 in interleukin-4-induced signaling, macrophage M2 polarization and allergic asthma response.	GNAI1 GNAI3	1.59e-05	2	139	2	33754034
Pubmed	Annexin A2 is a novel cellular redox regulatory protein involved in tumorigenesis.	ANXA2 ANXA2P2	1.59e-05	2	139	2	22185818
Pubmed	Naltrexone Facilitates Learning and Delays Extinction by Increasing AMPA Receptor Phosphorylation and Membrane Insertion.	GRIA1 OPRM1	1.59e-05	2	139	2	26049209
Pubmed	Epidermal growth factor induces tyrosine phosphorylation and reorganization of the tight junction protein ZO-1 in A431 cells.	TJP1 TJP2	1.59e-05	2	139	2	7542259
Pubmed	A competitive hexapeptide inhibitor of annexin A2 prevents hypoxia-induced angiogenic events.	ANXA2 ANXA2P2	1.59e-05	2	139	2	21486955
Pubmed	The PDZ2 domain of zonula occludens-1 and -2 is a phosphoinositide binding domain.	TJP1 TJP2	1.59e-05	2	139	2	19784548
Pubmed	Lipid raft endocytosis and exosomal transport facilitate extracellular trafficking of annexin A2.	ANXA2 ANXA2P2	1.59e-05	2	139	2	21737841
Pubmed	Altered expression of ZO-1 and ZO-2 in Sertoli cells and loss of blood-testis barrier integrity in testicular carcinoma in situ.	TJP1 TJP2	1.59e-05	2	139	2	17217619
Pubmed	Regulation of the low-dose radiation paracrine-specific anchorage-independent growth response by annexin A2.	ANXA2 ANXA2P2	1.59e-05	2	139	2	19580511
Pubmed	Monomeric α-catenin links cadherin to the actin cytoskeleton.	CTNNA1 CTNNA2	1.59e-05	2	139	2	23417122
Pubmed	Making sense of HIV innate sensing.	CGAS PPIA	1.59e-05	2	139	2	24332027
Pubmed	Effects of the differential expression of ZO-1 and ZO-2 on podocyte structure and function.	TJP1 TJP2	1.59e-05	2	139	2	29845705
Pubmed	MAGUK proteins: structure and role in the tight junction.	TJP1 TJP2	1.59e-05	2	139	2	10966866
Pubmed	Selenomethionine promotes ANXA2 phosphorylation for proliferation and protein synthesis of myoblasts and skeletal muscle growth.	ANXA2 ANXA2P2	1.59e-05	2	139	2	36739096
Pubmed	Methionine-induced hyperhomocysteinemia reverts fibrinolytic pathway activation in a murine model of acute promyelocytic leukemia.	ANXA2 ANXA2P2	1.59e-05	2	139	2	22517898
Pubmed	Over-expression of interleukin-1 beta-converting enzyme mRNA in staggerer cerebellum.	CASP1 RORA	1.59e-05	2	139	2	8905663
Pubmed	Anxa2 gene silencing attenuates obesity-induced insulin resistance by suppressing the NF-κB signaling pathway.	ANXA2 ANXA2P2	1.59e-05	2	139	2	30462534
Pubmed	Phosphorylation of nicastrin by SGK1 leads to its degradation through lysosomal and proteasomal pathways.	SGK1 NCSTN	1.59e-05	2	139	2	22590650
Pubmed	Establishment and characterization of cultured epithelial cells lacking expression of ZO-1.	TJP1 TJP2	1.59e-05	2	139	2	15292177
Pubmed	Inhibition of the membrane repair protein annexin-A2 prevents tumor invasion and metastasis.	ANXA2 ANXA2P2	1.59e-05	2	139	2	38092984
Pubmed	Tyrosine 23 phosphorylation-dependent cell-surface localization of annexin A2 is required for invasion and metastases of pancreatic cancer.	ANXA2 ANXA2P2	1.59e-05	2	139	2	21572519
Pubmed	Hypoxia-inducible factor-1 drives annexin A2 system-mediated perivascular fibrin clearance in oxygen-induced retinopathy in mice.	ANXA2 ANXA2P2	1.59e-05	2	139	2	21788340
Pubmed	The human genome encodes at least three non-allellic G proteins with alpha i-type subunits.	GNAI1 GNAI3	1.59e-05	2	139	2	2440724
Pubmed	The Membrane Phospholipid Binding Protein Annexin A2 Promotes Phagocytosis and Nonlytic Exocytosis of Cryptococcus neoformans and Impacts Survival in Fungal Infection.	ANXA2 ANXA2P2	1.59e-05	2	139	2	27371724
Pubmed	NHS-A isoform of the NHS gene is a novel interactor of ZO-1.	TJP1 NHS	1.59e-05	2	139	2	19447104
Pubmed	Comparison of methylation episignatures in KMT2B- and KMT2D-related human disorders.	KMT2B KMT2D	1.59e-05	2	139	2	35506254
Pubmed	Annexin A2 Deficiency Exacerbates Neuroinflammation and Long-Term Neurological Deficits after Traumatic Brain Injury in Mice.	ANXA2 ANXA2P2	1.59e-05	2	139	2	31817350
Pubmed	ANNEXIN A2 FACILITATES NEOVASCULARIZATION TO PROTECT AGAINST MYOCARDIAL INFARCTION INJURY VIA INTERACTING WITH MACROPHAGE YAP AND ENDOTHELIAL INTEGRIN Β3.	ANXA2 ANXA2P2	1.59e-05	2	139	2	37832154
Pubmed	Cell-surface translocation of annexin A2 contributes to bleomycin-induced pulmonary fibrosis by mediating inflammatory response in mice.	ANXA2 ANXA2P2	1.59e-05	2	139	2	30902828
Pubmed	Leri's pleonosteosis, a congenital rheumatic disease, results from microduplication at 8q22.1 encompassing GDF6 and SDC2 and provides insight into systemic sclerosis pathogenesis.	GDF6 SDC2	1.59e-05	2	139	2	24442880
Pubmed	Cell surface translocation of annexin A2 facilitates glutamate-induced extracellular proteolysis.	ANXA2 ANXA2P2	1.59e-05	2	139	2	24742684
Interaction	KIF20A interactions	CUL3 ZFAT RBMXL1 RPS3 ANXA2 LONRF1 IARS1 ANXA2P2 CGAS CHD4 PPIA LGALS4 LPIN1 RBMXL2 KHDRBS3 KHDRBS1 TJP1 RBMX TJP2 RORA MACROH2A2 GNAI1 GNAI3 SNRNP200 CDH9	3.39e-08	1052	136	25	int:KIF20A
Interaction	CIT interactions	CUL3 GPRASP1 RBMXL1 RPS3 ANXA2 IARS1 ANXA2P2 CGAS RAD21L1 CHD4 EDC4 CLPX PPIA MAP3K4 RBMXL2 NOP14 KHDRBS3 KHDRBS1 TJP1 RBMX TJP2 CSTF3 MACROH2A2 CTNNA1 QARS1 SNRNP200 KPNA3	1.20e-06	1450	136	27	int:CIT
Interaction	MYCN interactions	CUL3 MAGEB2 WBP11 RBMXL1 RPS3 ANXA2P2 VPS13C PCDHB2 CHD4 GPATCH8 PPIA SDAD1 MYEF2 POLR1D SETD2 NOP14 KHDRBS3 KHDRBS1 FAM32A MRPL16 CSNK1G3 RBMX MRPS5 MACROH2A2 SNRNP200 KPNA3	1.43e-06	1373	136	26	int:MYCN
Interaction	MECP2 interactions	WBP11 RBMXL1 RPS3 ANXA2 ARHGEF5 CHD9 CHD4 GPATCH8 PPIA SDAD1 MYEF2 POLR1D SETD2 NOP14 KHDRBS3 KHDRBS1 FAM32A MRPL16 TJP1 RBMX CSTF3 MACROH2A2 KDM1B SNRNP200 KPNA3	1.50e-06	1287	136	25	int:MECP2
Interaction	DHX8 interactions	MORC1 CUL3 MAGEB2 WBP11 RPS3 CHD4 GPATCH8 PPIA SETD2 RBMX SNRNP200	4.80e-06	292	136	11	int:DHX8
Interaction	KIF23 interactions	RBMXL1 RPS3 ANXA2 IARS1 ANXA2P2 CHD9 CHD4 CLPX ECHS1 PPIA MAP3K4 RBMXL2 NOP14 KHDRBS1 TJP1 RBMX TJP2 MACROH2A2 GNAI1 GNAI3 SNRNP200	5.65e-06	1031	136	21	int:KIF23
Interaction	GRB2 interactions	HEXB CUL3 WBP11 ANXA2 ARHGEF5 ANXA2P2 PAK4 CLPX ECHS1 PPIA TBC1D3B POLR1D KHDRBS1 SYNJ2 TBC1D3G SNRNP200 HCLS1 ARAP1	8.23e-06	806	136	18	int:GRB2
Interaction	CUL7 interactions	CUL3 TBC1D3 RPS3 ANXA2 IARS1 CHD4 ECHS1 PPIA MYEF2 SETD2 KHDRBS1 TJP1 RBMX CSTF3 MACROH2A2 CTNNA1 QARS1 SNRNP200	1.56e-05	845	136	18	int:CUL7
Interaction	NEBL interactions	CUL3 PPIA TJP1 TJP2 CTNNA1 QARS1	1.57e-05	79	136	6	int:NEBL
Interaction	ZC3H18 interactions	CUL3 MAGEB2 WBP11 RBMXL1 RPS3 ANXA2 IARS1 CHD4 NCSTN PPIA MYEF2 NOP14 KHDRBS3 RBMX MRPS5 MACROH2A2 SNRNP200 KPNA3	2.55e-05	877	136	18	int:ZC3H18
Interaction	CFAP141 interactions	WBP11 RBMXL1 KHDRBS3 TJP1 TJP2	3.45e-05	55	136	5	int:CFAP141
Cytoband	Ensembl 112 genes in cytogenetic band chr17q12	TBC1D3 TBC1D3H TBC1D3L TBC1D3D SLFN12 TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3F	3.56e-11	149	139	10	chr17q12
Cytoband	17q12	TBC1D3 TBC1D3H SLFN12 TBC1D3C TBC1D3B TBC1D3F	6.14e-07	99	139	6	17q12
Cytoband	15q22.2	ANXA2 VPS13C RORA	9.37e-05	29	139	3	15q22.2
Cytoband	3q13	MORC1 HCLS1	4.92e-04	11	139	2	3q13
Cytoband	Ensembl 112 genes in cytogenetic band chr15q22	ANXA2 VPS13C CLPX RORA	7.20e-04	132	139	4	chr15q22
GeneFamily	Signal transduction and activation of RNA metabolism family	KHDRBS3 KHDRBS1	6.53e-05	3	85	2	1275
GeneFamily	Zinc fingers CW-type	MORC1 KDM1B	4.52e-04	7	85	2	96
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT2B SETD2 KMT2D	5.40e-04	34	85	3	487
GeneFamily	Septins	SEPTIN5 SEPTIN4	1.65e-03	13	85	2	732
GeneFamily	Wiskott-Aldrich Syndrome protein family	WASH3P WASH4P	2.51e-03	16	85	2	14
GeneFamily	Aminoacyl tRNA synthetases, Class I	IARS1 QARS1	3.55e-03	19	85	2	131
Coexpression	TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_6HR_UP	PCDHB2 IFNB1 SCN2A GNAI1 CMAHP CDH9	6.52e-06	87	137	6	M18559
Coexpression	GSE3982_NEUTROPHIL_VS_BCELL_DN	IARS1 ANXA2P2 PPIA SDAD1 MAP3K4 LPIN1 KHDRBS1 AK2	1.00e-05	198	137	8	M5521
CoexpressionAtlas	Mesoderm Day 15_vs_Mesoderm Day 30-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3G TBC1D3F	1.15e-07	90	136	8	PCBC_ratio_MESO-15_vs_MESO-30_cfr-2X-p05
CoexpressionAtlas	DE cord blood_vs_DE blastocyst-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D ARHGEF5 TBC1D3C TBC1D3B TBC1D3G TBC1D3F	2.67e-05	242	136	9	PCBC_ratio_DE cord blood_vs_DE blastocyst_cfr-2X-p05
CoexpressionAtlas	Endoderm Differentiated Cells-method_mRNA_vs_Endoderm Differentiated Cells-method_NA-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3G TBC1D3F	7.05e-05	213	136	8	PCBC_ratio_DE_from-mRNA_vs_DE_from-ESC_cfr-2X-p05
CoexpressionAtlas	Endoderm Differentiated Cells-reprogram_OSKM-L_vs_Endoderm Differentiated Cells-reprogram_NA-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3G TBC1D3F	7.05e-05	213	136	8	PCBC_ratio_DE_from-OSKM-L_vs_DE_from-ESC_cfr-2X-p05
ToppCell	human_hepatoblastoma-Tumor_cells-T6\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	STARD13 OXR1 GRIA1 LPIN1 NHS CTNNA2 CFAP57	1.54e-06	179	139	7	14fc8ccb6b215063d747643f47d780d2b237eb67
ToppCell	LPS_only-Hematopoietic_Myeloid-Monocytes,_Macrophages-Monocytes-Macrophages\|LPS_only / Treatment groups by lineage, cell group, cell type	HK2 ANXA2 CASP1 ITGAL ARHGEF10L HCLS1 ARAP1	3.00e-06	198	139	7	2985c80e656e483866c696fa08c38af90311cd66
ToppCell	LPS_only-Hematopoietic_Myeloid-Monocytes,_Macrophages\|LPS_only / Treatment groups by lineage, cell group, cell type	HK2 ANXA2 CASP1 ITGAL ARHGEF10L HCLS1 ARAP1	3.00e-06	198	139	7	5d48539999d7a17f4165f612bf68be26c085e501
Disease	Congenital small ears	GDF6 EVC POLR1D KMT2D GNAI3	9.39e-07	41	128	5	C0152423
Disease	Tactile Amnesia	TAC1 GNAI1 GNAI3	5.19e-05	17	128	3	C0750906
Disease	Amnestic State	TAC1 GNAI1 GNAI3	5.19e-05	17	128	3	C0750907
Disease	Dissociative Amnesia	TAC1 GNAI1 GNAI3	5.19e-05	17	128	3	C0236795
Disease	Hysterical amnesia	TAC1 GNAI1 GNAI3	5.19e-05	17	128	3	C0233750
Disease	Temporary Amnesia	TAC1 GNAI1 GNAI3	5.19e-05	17	128	3	C0233796
Disease	Amnesia	TAC1 GNAI1 GNAI3	5.19e-05	17	128	3	C0002622
Disease	Global Amnesia	TAC1 GNAI1 GNAI3	5.19e-05	17	128	3	C0262497
Disease	autosomal dominant intellectual developmental disorder (is_implicated_in)	KMT2B GRIA1 SETD2	5.19e-05	17	128	3	DOID:0060307 (is_implicated_in)
Disease	CCL4 measurement	TBC1D3 SETD2 TBC1D3F	8.61e-05	20	128	3	EFO_0004751
Disease	leucine-rich repeat transmembrane neuronal protein 1 measurement	SARM1 CTNNA2	1.11e-04	4	128	2	EFO_0020531
Disease	catenin alpha-2 measurement	SARM1 C8A	1.85e-04	5	128	2	EFO_0802374
Disease	Malignant Cystosarcoma Phyllodes	SETD2 KMT2D	1.85e-04	5	128	2	C0600066
Disease	Phyllodes Tumor	SETD2 KMT2D	1.85e-04	5	128	2	C0010701
Disease	congenital heart disease (implicated_via_orthology)	KMT2B CHD9 KMT2D MYBPC3	2.35e-04	69	128	4	DOID:1682 (implicated_via_orthology)
Disease	macrophage inflammatory protein 1b measurement	TBC1D3 TBC1D3B SETD2 QARS1 TBC1D3F	3.25e-04	136	128	5	EFO_0008219
Disease	Morphine Abuse	GRIA1 OPRM1	3.87e-04	7	128	2	C0600272
Disease	annexin A2 measurement	ANXA2 RORA	3.87e-04	7	128	2	EFO_0008027
Disease	Morphine Dependence	GRIA1 OPRM1	3.87e-04	7	128	2	C0026552
Disease	McCune Albright syndrome (implicated_via_orthology)	GNAI1 GNAI3	5.14e-04	8	128	2	DOID:1858 (implicated_via_orthology)
Disease	Pruritus	OPRM1 TAC1	5.14e-04	8	128	2	C0033774
Disease	WNT1-inducible-signaling pathway protein 1 measurement	SARM1 C8A	8.21e-04	10	128	2	EFO_0008321
Disease	Alcoholic Intoxication, Chronic	ECHS1 OPRM1 TAC1 CTNNA2 CDH9 KPNA3	1.14e-03	268	128	6	C0001973
Disease	cleft palate (is_implicated_in)	GDF6 SDC2	1.20e-03	12	128	2	DOID:674 (is_implicated_in)
Disease	mouth morphology measurement	HEXB OXR1 RBMX	1.35e-03	50	128	3	EFO_0007955
Disease	Drug habituation	ZNF366 CSMD3 OPRM1 POLR1D	1.61e-03	115	128	4	C0013170
Disease	Drug abuse	ZNF366 CSMD3 OPRM1 POLR1D	1.61e-03	115	128	4	C0013146
Disease	Prescription Drug Abuse	ZNF366 CSMD3 OPRM1 POLR1D	1.61e-03	115	128	4	C4316881
Disease	Substance-Related Disorders	ZNF366 CSMD3 OPRM1 POLR1D	1.61e-03	115	128	4	C0236969
Disease	Drug Use Disorders	ZNF366 CSMD3 OPRM1 POLR1D	1.61e-03	115	128	4	C0013222
Disease	Drug Dependence	ZNF366 CSMD3 OPRM1 POLR1D	1.61e-03	115	128	4	C1510472
Disease	Substance Dependence	ZNF366 CSMD3 OPRM1 POLR1D	1.61e-03	115	128	4	C0038580
Disease	Substance Use Disorders	ZNF366 CSMD3 OPRM1 POLR1D	1.61e-03	115	128	4	C0038586
Disease	Organic Mental Disorders, Substance-Induced	ZNF366 CSMD3 OPRM1 POLR1D	1.61e-03	115	128	4	C0029231
Disease	renal cell carcinoma (biomarker_via_orthology)	ANXA2 ANXA2P2	1.64e-03	14	128	2	DOID:4450 (biomarker_via_orthology)
Disease	Substance abuse problem	ZNF366 CSMD3 OPRM1 POLR1D	1.66e-03	116	128	4	C0740858
Disease	cleft lip (is_implicated_in)	GDF6 SDC2	1.89e-03	15	128	2	DOID:9296 (is_implicated_in)
Disease	Neuralgia, Supraorbital	OPRM1 TAC1	2.15e-03	16	128	2	C0038870
Disease	Neuralgia	OPRM1 TAC1	2.15e-03	16	128	2	C0027796
Disease	Neuralgia, Atypical	OPRM1 TAC1	2.15e-03	16	128	2	C0234247
Disease	Neuralgia, Stump	OPRM1 TAC1	2.15e-03	16	128	2	C0234249
Disease	Neuralgia, Iliohypogastric Nerve	OPRM1 TAC1	2.15e-03	16	128	2	C0423712
Disease	Neuralgia, Perineal	OPRM1 TAC1	2.15e-03	16	128	2	C0423711
Disease	Paroxysmal Nerve Pain	OPRM1 TAC1	2.15e-03	16	128	2	C0751373
Disease	Nerve Pain	OPRM1 TAC1	2.15e-03	16	128	2	C0751372
Disease	Neuralgia, Ilioinguinal	OPRM1 TAC1	2.15e-03	16	128	2	C0751371
Disease	Neuralgia, Vidian	OPRM1 TAC1	2.15e-03	16	128	2	C0042656
Disease	C-C motif chemokine 3 measurement	GRIA1 TBC1D3B	2.73e-03	18	128	2	EFO_0008051
Disease	ceramide measurement	STARD13 OXR1 SLCO5A1 RBMX RORA	3.67e-03	235	128	5	EFO_0010222
Disease	Leber Congenital Amaurosis	IFT140 GDF6	4.07e-03	22	128	2	C0339527

Protein segments in the cluster

Peptide	Gene	Start	Entry
RDKEFRLKQSKIMGS	ATP6V1G3	51	Q96LB4
KSGTKDGLEKTRMAV	ARHGEF10L	251	Q9HCE6
MIFKRGVFESRRKNK	CFAP54	356	Q96N23
MKGIRKGESRAKESK	CSMD3	1	Q7Z407
ERKTGARGLRSIMEK	CLPX	556	O76031
KFGGGKTERARKAMA	C8A	401	P07357
REKKPKEVMGGFSRR	ARHGEF5	1071	Q12774
GKKKMSKLSRSARAG	MACROH2A2	6	Q9P0M6
SGRFMTSGKKKAVVI	CEP44	161	Q9C0F1
ELEKMKAGGNAKFRE	ARFGAP1	71	Q8N6T3
DSMKGKGTRDKVLIR	ANXA2	276	P07355
DSMKGKGTRDKVLIR	ANXA2P2	276	A6NMY6
MRSLRKGKDRTVAEG	CAVIN4	271	Q5BKX8
IKDTDVIMKRKRGGS	CGAS	291	Q8N884
FRKGKRKRTETMDSE	BEND6	16	Q5SZJ8
GFKLGRKMIQKESVR	RAD21L1	371	Q9H4I0
FRMKSKEGRAKAFST	OR5K2	226	Q8NHB8
ARDMNGKSLDGKAIK	RBMX	66	P38159
LKRKSKKDDGDAAMG	EDC4	921	Q6P2E9
FKMFDVGGQRSERKK	GNAI1	196	P63096
DLMEKLKGRTSRIAG	NCSTN	106	Q92542
LAVRGARVVSKGKKM	PCDHB2	61	Q9Y5E7
SEERKRSMPFKKGAA	LGALS4	86	P56470
GSMRIGKDFILFTKK	MORC1	106	Q86VD1
SFRGHMARKKIKSGE	NRGN	36	Q92686
KLESMGIRKDAKGIS	DZIP1L	466	Q8IYY4
EMLLRKFAESKGTGR	FCHO1	246	O14526
LKSVRMLSGSKEKDR	OPRM1	261	P35372
RIKSFKNKGRDVETM	KPNA3	11	O00505
SVTKGEMLKIVGKRF	MAGEB2	131	O15479
FKMFDVGGQRSERKK	GNAI3	196	P08754
TVGGKRFRVLKRGMK	LONRF1	641	Q17RB8
RLKGETGIMRKKFSS	CFAP57	891	Q96MR6
RAMVASGSELGKKLK	AK2	51	P54819
KRFRKEMEKGLGATT	HK2	41	P52789
DRKEGMTAFVEKRKA	ECHS1	271	P30084
ASTLSKLKRMKREEG	GPATCH8	371	Q9UKJ3
KLKRMKREEGAGATE	GPATCH8	376	Q9UKJ3
MASKPAAGKSRGEKR	JRK	1	O75564
EVTRAFMKILGKGKS	OR2M2	296	Q96R28
EVTRAFMKILGKGKS	OR2M3	296	Q8NG83
MSKKKGLSAEEKRTR	MND1	1	Q9BWT6
MASRKTKKKEGGALR	MYL5	1	Q02045
GRESRVKLEKGMDFI	PDPR	736	Q8NCN5
EGLESKRGFRMSSKK	CYLC1	571	P35663
RRAEGIKSGRMIFKK	CSTF3	386	Q12996
IKSGRMIFKKAREDT	CSTF3	391	Q12996
FDGKKRLDLSKMGIT	LRRC18	26	Q8N456
RFGKMGVLRSREKVV	LPIN1	51	Q14693
SGVEEKMFSLLKRAK	KMT2B	786	Q9UMN6
RMEAKDGSLKAKEGS	GPR101	276	Q96P66
MAKAKKVGARRKASG	NOP14	1	P78316
KDKDKSDDRMARPSG	CSNK1G3	6	Q9Y6M4
TGQKKTLDKKDGRRM	OXR1	76	Q8N573
TLDKKDGRRMSFQKP	OXR1	81	Q8N573
TASVEGKEEKKGRRM	CHD9	556	Q3L8U1
MATPRGRTKKKASFD	KDM1B	1	Q8NB78
LKEKRKLFIRSMGEG	CASP1	6	P29466
KKIAEAGSRMDKLAR	CTNNA2	746	P26232
AKKIAEAGSRMDKLG	CTNNA1	746	P35221
MGTSKKNEEEKRRGL	FAM32A	41	Q9Y421
KGTGSRKDTKMRIRA	CUL3	6	Q13618
LMFLDAERKKAERGK	TMEM63B	281	Q5T3F8
KLEKEDFTRGKLMSS	IFNB1	126	P01574
IKQFRSVKKMGGDEF	ATL2	426	Q8NHH9
LQMKRGAKFVSKRAD	EFHB	471	Q8N7U6
GNRFKKKSKEGSMLR	GBF1	1446	Q92538
SVLGKGSMRDKAKEE	KHDRBS1	196	Q07666
GSMRDKAKEEELRKG	KHDRBS1	201	Q07666
SILGKGSMRDKAKEE	KHDRBS3	96	O75525
AGDSGNSKKMLKRRS	EVC	976	P57679
EEGMIRVRKSKGKYA	GRIA1	701	P42261
MRQKGFGTDFKKLES	HEXB	371	P07686
NAIRGGKKASRMKKE	CHD4	826	Q14839
MSSKAEKKQRLSGRG	DNAH2	1	Q9P225
MRKKDEGSYDLGERK	SDC2	171	P34741
KIAGLTKDDGKMLRR	CDH9	36	Q9ULB4
EEVMKVKLSGKTGRR	IFT140	266	Q96RY7
MQGEDARYLKRKVKG	KIFAP3	1	Q92845
DLKTSRGLFEEMKKT	MTBP	871	Q96DY7
MFGKRKKRVEISAPS	PAK4	1	O96013
RASKALGFAKMLRKD	MAP3K4	811	Q9Y6R4
LKEAKRGKTRAETMG	POLR1D	16	P0DPB5
AGKEAKFRSKMRAGK	GPRASP1	311	Q5JY77
ELGSTKGMRSRKEGK	GDF6	36	Q6KF10
AAKAVSRGTLEKMRK	MRPL16	186	Q9NX20
RNVFTMTAKEGRKKS	MRPS5	226	P82675
RKGKFSEGEATLRMK	QARS1	391	P47897
GTRKQMFRPGKEETK	SYNPO2L	631	Q9H987
AKSFLKRMETLRGKG	STARD13	256	Q9Y3M8
ARDMNGKSLDGKAIK	RBMXL1	66	Q96E39
KDRTSLMKGAKDIAR	SV2C	6	Q496J9
GKSMPKRKGEAATRA	TATDN2	196	Q93075
RKSVKKGFDFTLMVA	SEPTIN4	136	O43236
RKSVKKGFDFTLMVA	SEPTIN5	36	Q99719
AMERFGSRNGKTSKK	PPIA	141	P62937
KAKVGKLKDGARSMS	SYNJ2	451	O15056
RGLKAKFESMAEEKR	HCLS1	236	P14317
RADIKEDKDGKSRGM	MYEF2	261	Q9P2K5
SKRKVLGRKDSGDMS	NHS	1451	Q6T4R5
FGKDAASFLTRMKEK	PTGIS	46	Q16647
AMADRLGKFLKTKTD	FSD2	326	A1L4K1
RTKRLGAKDDFMEIK	SGK1	336	O00141
DKKVSSMGFGKDVRD	SLCO5A1	406	Q9H2Y9
KLRGQRAKSMKFVDG	RPS3	141	P23396
GLVLASDGQKMSKRK	IARS1	591	P41252
LGKRLKGAFKAVMTS	IARS1	901	P41252
TAMAGKTDRKEFVRK	SDAD1	616	Q9NVU7
FFKRNLKEKMEAGRG	ITGAL	1116	P20701
GRYQIMKEKGKRSSE	TBC1D3L	126	B9A6J9
ARDMNGKSLDGKAIK	RBMXL2	66	O75526
GAGVSKVRSLKMDRK	ARAP1	581	Q96P48
LDLGRMLKDRTDSKG	CMAHP	301	Q9Y471
GRYQIMKEKGKRSSE	TBC1D3B	126	A6NDS4
GRYQIMKEKGKRSSE	TBC1D3H	126	P0C7X1
EAGRKAVKGTMKRTC	WNT8B	166	Q93098
SKTGDEFLVMKRKRG	ZFAT	61	Q9P243
EFLVMKRKRGRPKGS	ZFAT	66	Q9P243
KMVRFKKGDSVGLRL	TJP2	511	Q9UDY2
GMKSGITRKRFFREL	SARM1	456	Q6SZW1
GRYQIMKEKGKRSSE	TBC1D3F	126	A6NER0
DAVKFGRMSKKQRDS	RORA	141	P35398
FNKLVMRRKGISGKG	WASH4P	426	A8MWX3
AVGRMQKGIDFVKRK	SCN2A	1006	Q99250
ARIKRMVFKGGRTET	VWA2	116	Q5GFL6
FNKLVMRRKGISGKG	WASH3P	411	C4AMC7
AALEFLKDMKKTRGR	SLFN12	141	Q8IYM2
RKTDGKIKDMFSGEE	SERPINI2	156	O75830
EKDIRMARFKVSGGL	VPS13C	796	Q709C8
GFFRSLMSLKRKEKG	ARHGAP19	96	Q14CB8
SIRAAGGKMKKERSR	SETD2	1696	Q9BYW2
SMKLVKFRKGDSVGL	TJP1	421	Q07157
KLEGTRMGDKAQRTK	SNRNP200	46	O75643
FEGAGSRKRKSMPTK	ZNF366	71	Q8N895
GGRTRMEKELQAKYK	ZBED9	321	Q6R2W3
GRYQIMKEKGKRSSE	TBC1D3D	126	A0A087WVF3
LSVRFADMPGKSRKK	WBP11	306	Q9Y2W2
GRYQIMKEKGKRSSE	TBC1D3G	126	Q6DHY5
GRYQIMKEKGKRSSE	TBC1D3	126	Q8IZP1
KRHKTDSFVGLMGKR	TAC1	96	P20366
GRYQIMKEKGKRSSE	TBC1D3I	126	A0A087WXS9
GRYQIMKEKGKRSSE	TBC1D3C	126	Q6IPX1
RTDFIKGMKKKSRAE	VWA5B1	306	Q5TIE3
RRGRKKSKLEDMFPA	KMT2D	1756	O14686
SRSEKKARKAMSKLG	NACAD	1411	O15069
RLKGMRRDEKKSTAF	MYBPC3	351	Q14896