Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	TSP_1	ADAMTS4 UNC5D ADGRB1	1.01e-04	63	27	3	PF00090
Domain	TSP1	ADAMTS4 UNC5D ADGRB1	1.11e-04	65	27	3	SM00209
Domain	TSP1_rpt	ADAMTS4 UNC5D ADGRB1	1.11e-04	65	27	3	IPR000884
Domain	TSP1	ADAMTS4 UNC5D ADGRB1	1.11e-04	65	27	3	PS50092
Domain	GPS	ADGRG5 ADGRB1	1.10e-03	34	27	2	SM00303
Domain	GPS	ADGRG5 ADGRB1	1.16e-03	35	27	2	PF01825
Domain	GPS	ADGRG5 ADGRB1	1.23e-03	36	27	2	PS50221
Domain	GPS	ADGRG5 ADGRB1	1.30e-03	37	27	2	IPR000203
Domain	G_PROTEIN_RECEP_F2_1	ADGRG5 ADGRB1	1.52e-03	40	27	2	PS00649
Domain	G_PROTEIN_RECEP_F2_3	ADGRG5 ADGRB1	1.52e-03	40	27	2	PS50227
Domain	GPCR_2_extracellular_dom	ADGRG5 ADGRB1	1.52e-03	40	27	2	IPR001879
Domain	G_PROTEIN_RECEP_F2_2	ADGRG5 ADGRB1	2.36e-03	50	27	2	PS00650
Domain	7tm_2	ADGRG5 ADGRB1	2.36e-03	50	27	2	PF00002
Domain	GPCR_2-like	ADGRG5 ADGRB1	3.38e-03	60	27	2	IPR017981
Domain	GPCR_2_secretin-like	ADGRG5 ADGRB1	3.38e-03	60	27	2	IPR000832
Domain	G_PROTEIN_RECEP_F2_4	ADGRG5 ADGRB1	3.49e-03	61	27	2	PS50261
Pubmed	An emerging role for Wnt and GSK3 signaling pathways in schizophrenia.	WNT1 DISC1	3.75e-06	4	28	2	23379509
Pubmed	Definition of Prostaglandin E2-EP2 Signals in the Colon Tumor Microenvironment That Amplify Inflammation and Tumor Growth.	PTGES2 PTGER1	1.31e-05	7	28	2	26018088
Pubmed	Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102.	GRIN2C ADGRB1	4.10e-05	12	28	2	11937501
Pubmed	Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis.	PTGES2 PTGER1	2.17e-04	27	28	2	23624557
Pubmed	The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.	ADGRG5 ADGRB1	2.50e-04	29	28	2	15203201
Pubmed	Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts.	PTGES2 PTGER1	3.25e-04	33	28	2	39002541
Pubmed	International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.	ADGRG5 ADGRB1	3.25e-04	33	28	2	25713288
Cytoband	8q24.3	ZNF517 KIFC2 ADGRB1	4.55e-05	113	28	3	8q24.3
Cytoband	Ensembl 112 genes in cytogenetic band chr8q24	ZNF517 KIFC2 ADGRB1	1.30e-03	355	28	3	chr8q24
Cytoband	Ensembl 112 genes in cytogenetic band chr20p13	GFRA4 RBCK1	2.57e-03	123	28	2	chr20p13
Drug	ONO-AE-329	PTGES2 PTGER1	1.46e-05	5	28	2	CID005311230
Drug	TEI-3356	PTGES2 PTGER1	4.07e-05	8	28	2	CID006439368
Drug	Tei-9063	PTGES2 PTGER1	5.22e-05	9	28	2	CID005311245
Drug	AFP-07	PTGES2 PTGER1	5.22e-05	9	28	2	CID005311226
Drug	AC1L1BMC	LOXL3 PTGER1	5.22e-05	9	28	2	CID000001500
Drug	PGE1 alcohol	PTGES2 PTGER1	6.52e-05	10	28	2	CID005283054
Drug	17-phenyl-trinor-prostaglandin E2	PTGES2 PTGER1	6.52e-05	10	28	2	CID000001450
Drug	enisoprost	PTGES2 PTGER1	7.97e-05	11	28	2	CID005311219
Drug	Butylparaben [94-26-8]; Down 200; 20.6uM; MCF7; HT_HG-U133A	PXN PDE3B SNAPC4 DISC1	8.74e-05	193	28	4	5608_DN
Drug	CGX 0596987; Down 200; 20uM; PC3; HT_HG-U133A	DDN SNAPC4 ING1 DISC1	8.91e-05	194	28	4	6417_DN
Drug	Rp-cAMPS	PTGES2 PDE3B GRIN2C PTGER1	8.91e-05	194	28	4	CID006426631
Drug	Piroxicam [36322-90-4]; Down 200; 12uM; PC3; HT_HG-U133A	PTGES2 TRPC4AP ING1 RBCK1	9.28e-05	196	28	4	2089_DN
Drug	Ciprofibrate [52214-84-3]; Down 200; 13.8uM; MCF7; HT_HG-U133A	TRPC4AP SNAPC4 DISC1 RBCK1	9.46e-05	197	28	4	6218_DN
Drug	Flucloxacillin sodium [1847-24-1]; Down 200; 8.4uM; MCF7; HT_HG-U133A	PDE3B ING1 DISC1 RBCK1	9.46e-05	197	28	4	5527_DN
Drug	GR63799	PTGES2 PTGER1	9.55e-05	12	28	2	CID005311224
Drug	Lysergol [602-85-7]; Down 200; 15.8uM; MCF7; HT_HG-U133A	PXN PTGES2 DISC1 RBCK1	9.65e-05	198	28	4	3261_DN
Drug	2-propylpentanoic acid; Down 200; 50uM; MCF7; HT_HG-U133A	PXN PDE3B SNAPC4 ING1	9.65e-05	198	28	4	5582_DN
Drug	Spironolactone [52-01-7]; Down 200; 9.6uM; MCF7; HT_HG-U133A	PXN PDE3B DISC1 RBCK1	9.65e-05	198	28	4	2226_DN
Drug	Josamycin [16846-24-5]; Down 200; 4.8uM; MCF7; HT_HG-U133A	PXN PDE3B SNAPC4 ING1	9.65e-05	198	28	4	1534_DN
Drug	Lisinopril [83915-83-7]; Down 200; 9uM; MCF7; HT_HG-U133A	PXN TRPC4AP SNAPC4 ING1	9.84e-05	199	28	4	7403_DN
Drug	Azathioprine [446-86-6]; Down 200; 14.4uM; MCF7; HT_HG-U133A	PXN PDE3B TRPC4AP SNAPC4	9.84e-05	199	28	4	1528_DN
Drug	ZK118182	PTGES2 PTGER1	1.13e-04	13	28	2	CID005311208
Drug	MB28767	PTGES2 PTGER1	1.13e-04	13	28	2	CID005311223
Drug	AC1L1GOT	PTGES2 PTGER1	1.13e-04	13	28	2	CID000003777
Drug	AC1NSKAN	PTGES2 PTGER1	1.32e-04	14	28	2	CID005311244
Drug	5-enolpyruvoylshikimate-3-phosphate	PTGES2 TRPC4AP PTGER1	1.48e-04	84	28	3	CID000000082
Drug	ONO-DI-004	PTGES2 PTGER1	1.52e-04	15	28	2	CID005311227
Drug	7-oxa-13-prostynoic acid	PTGES2 PTGER1	1.52e-04	15	28	2	CID000033731
Drug	AH13205	PTGES2 PTGER1	1.52e-04	15	28	2	CID000132836
Drug	SC-51089	PTGES2 PTGER1	1.52e-04	15	28	2	CID000132748
Drug	ZK110841	PTGES2 PTGER1	1.52e-04	15	28	2	CID005311503
Drug	HQL-79	PTGES2 PDE3B	2.20e-04	18	28	2	CID006540277
Disease	obesity (implicated_via_orthology)	ADAMTS4 NEIL1 WNT1	9.81e-04	215	27	3	DOID:9970 (implicated_via_orthology)
Disease	JT interval	PXN PTGES2 TRPC4AP	1.48e-03	248	27	3	EFO_0007885
Disease	pulse pressure measurement, alcohol drinking	C1orf167 UNC5D	1.87e-03	70	27	2	EFO_0004329, EFO_0005763
Disease	Bell's palsy	LOXL3 DISC1	3.93e-03	102	27	2	EFO_0007167
Disease	attention deficit hyperactivity disorder, autism spectrum disorder, intelligence	DDN PTGES2 WNT1	5.60e-03	398	27	3	EFO_0003756, EFO_0003888, EFO_0004337
Disease	serum alanine aminotransferase measurement	PTGES2 ZNF517 KIFC2 DISC1	7.64e-03	869	27	4	EFO_0004735
Disease	response to antidepressant	DISC1 ADGRB1	1.13e-02	176	27	2	GO_0036276

Protein segments in the cluster

Peptide	Gene	Start	Entry
PGLRSWGGLGSWRSR	C1orf167	386	Q5SNV9
LRLWGRGGCWPRGLQ	AFG3L2	6	Q9Y4W6
SAPPQLGPWSWRGCR	ADGRB1	896	O14514
PDPHWWRGRSCGRVG	GRAP	191	Q13588
GSAWAGPWGGRRPGP	DDN	186	O94850
RLSWPCGPGSAGWQQ	DISC1	131	Q9NRI5
GPGPLRWGLICGDDW	LOXL3	436	P58215
GRWDLGGKWQPGRGP	NEIL1	121	Q96FI4
EICWVTKGPRWGPGG	RBCK1	471	Q9BYM8
RGPGPGRSCGSWWLL	PDE3B	141	Q13370
TWCFIGLGPPGGWRQ	PTGER1	186	P34995
GPSAWRASPAGWAGR	FAM218A	16	Q96MZ4
WAAGWPRDGGRSSPG	PXN	291	P49023
SHPGRGLAGRWLWGA	ADAMTS4	6	O75173
AAGPWRGWGRGLSPA	GFRA4	136	Q9GZZ7
LLRWWRSPGPGAGAP	CERK	31	Q8TCT0
GSRPCPWGLRPGLCW	KIFC2	821	Q96AC6
TVAAWGGWGGRPRPG	TRPC4AP	21	Q8TEL6
GLQPWIGSSRCWGGP	ING1	61	Q9UK53
LWPGGCALAWRLGGR	PTGES2	11	Q9H7Z7
LWGTPRLPCSPGWQG	IARS2	21	Q9NSE4
ARKQPWGGWSPEGCR	ADGRG5	196	Q8IZF4
AGPGWAPWPRGARRL	RNF225	311	M0QZC1
GGGARRWLPWLGLCF	UNC5D	11	Q6UXZ4
QAGLPGTVWGCLPWG	ZNF517	111	Q6ZMY9
RRRGPGGPDWHWGGC	WNT1	156	P04628
QPWRGGAGAWLGGPA	SNAPC4	581	Q5SXM2
PSGLLPQRRGGPSWW	nan	76	Q6ZSA8
SWLSGAWGPLGHRGR	GRIN2C	1176	Q14957