Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsodium ion binding

SCN3A SCN9A

3.16e-0414382GO:0031402
GeneOntologyCellularComponentGolgi lumen

MUC16 MUC5B MUC17 MUC5AC

5.53e-05109404GO:0005796
GeneOntologyCellularComponentvoltage-gated sodium channel complex

SCN3A SCN9A

4.77e-0417402GO:0001518
DomainNa_trans_cytopl

SCN3A SCN9A

6.67e-056402PF11933
DomainWxxW_domain

MUC5B MUC5AC

6.67e-056402IPR025155
DomainMucin2_WxxW

MUC5B MUC5AC

6.67e-056402PF13330
DomainNa_trans_cytopl

SCN3A SCN9A

6.67e-056402IPR024583
DomainNa_channel_asu

SCN3A SCN9A

1.99e-0410402IPR001696
DomainNa_trans_assoc

SCN3A SCN9A

1.99e-0410402IPR010526
DomainNa_trans_assoc

SCN3A SCN9A

1.99e-0410402PF06512
DomainTIL

MUC5B MUC5AC

2.91e-0412402PF01826
DomainC8

MUC5B MUC5AC

2.91e-0412402PF08742
DomainUnchr_dom_Cys-rich

MUC5B MUC5AC

3.44e-0413402IPR014853
DomainC8

MUC5B MUC5AC

3.44e-0413402SM00832
DomainSEA

MUC16 MUC17

4.00e-0414402SM00200
DomainTIL_dom

MUC5B MUC5AC

4.00e-0414402IPR002919
DomainGlyco_hormone_CN

MUC5B MUC5AC

4.61e-0415402IPR006208
DomainCys_knot

MUC5B MUC5AC

4.61e-0415402PF00007
Domain-

MUC16 MUC17

4.61e-04154023.30.70.960
DomainVWFD

MUC5B MUC5AC

5.27e-0416402PS51233
DomainVWD

MUC5B MUC5AC

5.27e-0416402SM00216
DomainVWF_type-D

MUC5B MUC5AC

5.27e-0416402IPR001846
DomainVWD

MUC5B MUC5AC

5.27e-0416402PF00094
DomainCTCK_1

MUC5B MUC5AC

6.70e-0418402PS01185
DomainVWC_out

MUC5B MUC5AC

7.47e-0419402SM00215
DomainSEA

MUC16 MUC17

1.01e-0322402PF01390
DomainCT

MUC5B MUC5AC

1.01e-0322402SM00041
DomainZF_PHD_2

BPTF ASXL3 KDM5C

1.10e-0395403PS50016
DomainSEA

MUC16 MUC17

1.10e-0323402PS50024
DomainSEA_dom

MUC16 MUC17

1.10e-0323402IPR000082
DomainZF_PHD_1

BPTF ASXL3 KDM5C

1.13e-0396403PS01359
DomainCys_knot_C

MUC5B MUC5AC

1.30e-0325402IPR006207
DomainCTCK_2

MUC5B MUC5AC

1.30e-0325402PS01225
DomainVWC

MUC5B MUC5AC

1.63e-0328402PF00093
DomainMAGE

MAGEB2 MAGEC1

2.40e-0334402SM01373
DomainMAGE

MAGEB2 MAGEC1

2.69e-0336402PS50838
DomainMHD_dom

MAGEB2 MAGEC1

2.69e-0336402IPR002190
DomainVWFC_1

MUC5B MUC5AC

2.69e-0336402PS01208
DomainMAGE

MAGEB2 MAGEC1

2.69e-0336402PF01454
DomainVWC

MUC5B MUC5AC

2.99e-0338402SM00214
DomainVWFC_2

MUC5B MUC5AC

2.99e-0338402PS50184
DomainVWF_dom

MUC5B MUC5AC

3.65e-0342402IPR001007
DomainChannel_four-helix_dom

SCN3A SCN9A

6.63e-0357402IPR027359
Domain-

SCN3A SCN9A

6.63e-03574021.20.120.350
DomainZinc_finger_PHD-type_CS

BPTF KDM5C

8.54e-0365402IPR019786
DomainIQ

SCN3A SCN9A

1.01e-0271402PF00612
PathwayREACTOME_DEFECTIVE_GALNT3_CAUSES_HFTC

MUC16 MUC5B MUC17 MUC5AC

1.91e-0816274M27410
PathwayREACTOME_DEFECTIVE_C1GALT1C1_CAUSES_TNPS

MUC16 MUC5B MUC17 MUC5AC

2.50e-0817274M27412
PathwayREACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS

MUC16 MUC5B MUC17 MUC5AC

6.25e-0821274MM15706
PathwayREACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS

MUC16 MUC5B MUC17 MUC5AC

9.22e-0823274M556
PathwayREACTOME_DECTIN_2_FAMILY

MUC16 MUC5B MUC17 MUC5AC

1.55e-0726274M27483
PathwayREACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS

MUC16 MUC5B MUC17 MUC5AC

4.84e-0660274MM15636
PathwayREACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS

MUC16 MUC5B MUC17 MUC5AC

5.52e-0662274M546
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

MUC16 MUC5B MUC17 MUC5AC

7.99e-0668274M27303
PathwayREACTOME_O_LINKED_GLYCOSYLATION

MUC16 MUC5B MUC17 MUC5AC

5.17e-05109274MM15164
PathwayREACTOME_O_LINKED_GLYCOSYLATION

MUC16 MUC5B MUC17 MUC5AC

5.56e-05111274M27416
PathwayREACTOME_C_TYPE_LECTIN_RECEPTORS_CLRS

MUC16 MUC5B MUC17 MUC5AC

1.37e-04140274M27484
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

MUC16 MUC5B MUC17 MUC5AC

1.49e-04143274M27275
PathwayREACTOME_DISEASES_OF_METABOLISM

MUC16 MUC5B MUC17 MUC5AC

1.23e-03250274M27554
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SCN3A SCN9A

1.59e-0331272M877
PathwayREACTOME_PHASE_0_RAPID_DEPOLARISATION

SCN3A SCN9A

1.69e-0332272M27455
PathwayREACTOME_CARDIAC_CONDUCTION

ATP2B2 SCN3A SCN9A

1.91e-03130273M27454
PathwayREACTOME_SENSORY_PERCEPTION_OF_TASTE

SCN3A SCN9A

3.62e-0347272M42524
Pubmed

Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux.

MUC16 MUC5B MUC17 MUC5AC

5.02e-091841418834073
Pubmed

Expression of Muc19/Smgc gene products during murine sublingual gland development: cytodifferentiation and maturation of salivary mucous cells.

MUC16 MUC5B MUC5AC

3.03e-08641319110483
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

CEP170 NAV1 BPTF DCLK2 TANC1 QSER1 ZNF827 TLE3 CUX1 AGAP1 ENAH PDZD2

9.03e-081489411228611215
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

CEP170 NAV1 CCDC88C NYAP2 QSER1 MGA CLIP1 ADAM22 CUX1 ENAH

1.30e-07963411028671696
Pubmed

A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.

CEP170 BPTF TANC1 EYA3 CLIP1 TLE3 CUX1

1.22e-0647241738943005
Pubmed

Cloning and analysis of cDNA encoding a major airway glycoprotein, human tracheobronchial mucin (MUC5).

MUC5B MUC5AC

1.36e-0624127513696
Pubmed

Mucin deficiency causes functional and structural changes of the ocular surface.

MUC5B MUC5AC

1.36e-06241223272068
Pubmed

Muc5b is mainly expressed and sialylated in the nasal olfactory epithelium whereas Muc5ac is exclusively expressed and fucosylated in the nasal respiratory epithelium.

MUC5B MUC5AC

1.36e-06241231030254
Pubmed

Younger patients with COME are more likely to have mucoid middle ear fluid containing mucin MUC5B.

MUC5B MUC5AC

1.36e-06241227729120
Pubmed

Airway mucin MUC5AC and MUC5B concentrations and the initiation and progression of chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort.

MUC5B MUC5AC

1.36e-06241234058148
Pubmed

The association between MUC5AC and MUC5B genes expression and remodeling progression in severe neutrophilic asthma: A direct relationship.

MUC5B MUC5AC

1.36e-06241237146737
Pubmed

The idiopathic pulmonary fibrosis honeycomb cyst contains a mucocilary pseudostratified epithelium.

MUC5B MUC5AC

1.36e-06241223527003
Pubmed

MUC5AC and MUC5B Mucins Are Decreased in Cystic Fibrosis Airway Secretions.

MUC5B MUC5AC

1.36e-06241214988081
Pubmed

Up-regulation of MUC5AC and MUC5B mucin genes in nasopharyngeal respiratory mucosa and selective up-regulation of MUC5B in middle ear in pediatric otitis media with effusion.

MUC5B MUC5AC

1.36e-06241216540890
Pubmed

Mucin glycosylation changes in cystic fibrosis lung disease are not manifest in submucosal gland secretions.

MUC5B MUC5AC

1.36e-06241215563276
Pubmed

De novo NUF2 variant in a novel inherited bone marrow failure syndrome including microcephaly and renal hypoplasia.

MUC5B MUC5AC

1.36e-06241236111525
Pubmed

Alterations of the ocular surface epithelial MUC16 and goblet cell MUC5AC in patients with atopic keratoconjunctivitis.

MUC16 MUC5AC

1.36e-06241218782111
Pubmed

The expression of MUC5AC and MUC5B mucin genes in the mucosa of chronic rhinosinusitis and nasal polyposis.

MUC5B MUC5AC

1.36e-06241217621824
Pubmed

Association of KIR2DL5B gene with celiac disease supports the susceptibility locus on 19q13.4.

KIR2DL5A KIR2DL5B

1.36e-06241217215859
Pubmed

Enhanced discrimination of malignant from benign pancreatic disease by measuring the CA 19-9 antigen on specific protein carriers.

MUC16 MUC5AC

1.36e-06241222220206
Pubmed

Muc5b is required for airway defence.

MUC5B MUC5AC

1.36e-06241224317696
Pubmed

Abnormalities in MUC5AC and MUC5B Protein in Airway Mucus in Asthma.

MUC5B MUC5AC

1.36e-06241227845589
Pubmed

Some human KIR haplotypes contain two KIR2DL5 genes: KIR2DL5A and KIR2DL5B.

KIR2DL5A KIR2DL5B

1.36e-06241212185535
Pubmed

Macrophages are related to goblet cell hyperplasia and induce MUC5B but not MUC5AC in human bronchus epithelial cells.

MUC5B MUC5AC

1.36e-06241222391959
Pubmed

C-Mannosylation of MUC5AC and MUC5B Cys subdomains.

MUC5B MUC5AC

1.36e-06241214718370
Pubmed

Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules.

MUC5B MUC5AC

1.36e-06241235776514
Pubmed

Contribution of mucus concentration and secreted mucins Muc5ac and Muc5b to the pathogenesis of muco-obstructive lung disease.

MUC5B MUC5AC

1.36e-06241227435107
Pubmed

Gene structure and promoter variation of expressed and nonexpressed variants of the KIR2DL5 gene.

KIR2DL5A KIR2DL5B

1.36e-06241211086080
Pubmed

The ocular surface phenotype of Muc5ac and Muc5b null mice.

MUC5B MUC5AC

1.36e-06241224327612
Pubmed

Mucins MUC5B and MUC5AC in Distal Airways and Honeycomb Spaces: Comparison among Idiopathic Pulmonary Fibrosis/Usual Interstitial Pneumonia, Fibrotic Nonspecific Interstitial Pneumonitis, and Control Lungs.

MUC5B MUC5AC

1.36e-06241226871672
Pubmed

Mucin production during prenatal and postnatal murine lung development.

MUC5B MUC5AC

1.36e-06241221653907
Pubmed

MUC5B mobilizes and MUC5AC spatially aligns mucociliary transport on human airway epithelium.

MUC5B MUC5AC

1.36e-06241236427316
Pubmed

Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression.

SCN3A SCN9A

1.36e-06241225172946
Pubmed

Normal murine respiratory tract has its mucus concentrated in clouds based on the Muc5b mucin.

MUC5B MUC5AC

1.36e-06241232348677
Pubmed

In silico cloning of mouse Muc5b gene and upregulation of its expression in mouse asthma model.

MUC5B MUC5AC

1.36e-06241211587997
Pubmed

Gel-forming mucins form distinct morphologic structures in airways.

MUC5B MUC5AC

1.36e-06241228607090
Pubmed

Pathobiological implications of mucin (MUC) expression in the outcome of small bowel cancer.

MUC16 MUC5AC

1.36e-06241224722639
Pubmed

Reassessment of the importance of mucins in determining sputum properties in cystic fibrosis.

MUC5B MUC5AC

1.36e-06241224332705
Pubmed

Pathophysiological relevance of sputum MUC5AC and MUC5B levels in patients with mild asthma.

MUC5B MUC5AC

1.36e-06241234656442
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

CEP170 BPTF QSER1 MGA CUX1 WDR44 ENAH

3.32e-0654941738280479
Pubmed

Voltage-gated sodium channels in taste bud cells.

SCN3A SCN9A

4.06e-06341219284629
Pubmed

Assessment of mucin-related gene alterations following treatment with rebamipide ophthalmic suspension in Sjögren's syndrome-associated dry eyes.

MUC16 MUC5AC

4.06e-06341233232357
Pubmed

Interleukin-33 induces mucin gene expression and goblet cell hyperplasia in human nasal epithelial cells.

MUC5B MUC5AC

4.06e-06341227776277
Pubmed

Autophagy of mucin granules contributes to resolution of airway mucous metaplasia.

MUC5B MUC5AC

4.06e-06341234158522
Pubmed

Resistin upregulates MUC5AC/B mucin gene expression in human airway epithelial cells.

MUC5B MUC5AC

4.06e-06341229604272
Pubmed

High-Mobility Group Box 1 Upregulates MUC5AC and MUC5B Expression in Primary Airway Epithelial Cells.

MUC5B MUC5AC

4.06e-06341229286856
Pubmed

Mutations in the sodium channel genes SCN1A, SCN3A, and SCN9A in children with epilepsy with febrile seizures plus(EFS+).

SCN3A SCN9A

4.06e-06341233895391
Pubmed

IL-8 regulates mucin gene expression at the posttranscriptional level in lung epithelial cells.

MUC5B MUC5AC

4.06e-06341219596978
Pubmed

DUSP28 links regulation of Mucin 5B and Mucin 16 to migration and survival of AsPC-1 human pancreatic cancer cells.

MUC16 MUC5B

4.06e-06341227230679
Pubmed

Promoter variants of KIR2DL5 add to diversity and may impact gene expression.

KIR2DL5A KIR2DL5B

4.06e-06341218461314
Pubmed

Nebulized Menthol Impairs Mucociliary Clearance via TRPM8 and MUC5AC/MUC5B in Primary Airway Epithelial Cells.

MUC5B MUC5AC

4.06e-06341236675209
Pubmed

Abnormal expression of voltage-gated sodium channels Nav1.7, Nav1.3 and Nav1.8 in trigeminal neuralgia.

SCN3A SCN9A

4.06e-06341219699781
Pubmed

Regulation of neuregulin 1beta1-induced MUC5AC and MUC5B expression in human airway epithelium.

MUC5B MUC5AC

4.06e-06341219556605
Pubmed

Aquaporin 5 expression increases mucin production in lung adenocarcinoma.

MUC5B MUC5AC

4.06e-06341221455588
Pubmed

Th2 cytokines orchestrate the secretion of MUC5AC and MUC5B in IL-5-positive chronic rhinosinusitis with nasal polyps.

MUC5B MUC5AC

4.06e-06341229802623
Pubmed

Expression of leptin receptor in nasal polyps: leptin as a mucosecretagogue.

MUC5B MUC5AC

4.06e-06341220422702
Pubmed

Mucin gene polymorphisms in otitis media patients.

MUC5B MUC5AC

4.06e-06341219718741
Pubmed

Killer-cell immunoglobulin-like receptors (KIR) in severe A (H1N1) 2009 influenza infections.

KIR2DL5A KIR2DL5B

8.12e-06441222652695
Pubmed

Nav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis.

NAV1 SCN9A

8.12e-06441238172636
Pubmed

KIR2DL5, a novel killer-cell receptor with a D0-D2 configuration of Ig-like domains.

KIR2DL5A KIR2DL5B

8.12e-06441210820258
Pubmed

ILC2s mediate systemic innate protection by priming mucus production at distal mucosal sites.

MUC5B MUC5AC

8.12e-06441231582416
Pubmed

Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype.

MUC5B MUC5AC

8.12e-06441223807779
Pubmed

Mouse neuron navigator 1, a novel microtubule-associated protein involved in neuronal migration.

NAV1 CLIP1

8.12e-06441215797708
Pubmed

Increased expression of MUC5AC and MUC5B promoting bacterial biofilm formation in chronic rhinosinusitis patients.

MUC5B MUC5AC

8.12e-06441225638393
Pubmed

Epigenetic regulation (DNA methylation, histone modifications) of the 11p15 mucin genes (MUC2, MUC5AC, MUC5B, MUC6) in epithelial cancer cells.

MUC5B MUC5AC

8.12e-06441217471237
Pubmed

MCP-1/CCR2B-dependent loop upregulates MUC5AC and MUC5B in human airway epithelium.

MUC5B MUC5AC

8.12e-06441221097527
Pubmed

Expression of MUC1, MUC2, MUC5AC and MUC5B in mucinous lesions of the breast.

MUC5B MUC5AC

8.12e-06441222269464
Pubmed

The mouse secreted gel-forming mucin gene cluster.

MUC5B MUC5AC

8.12e-06441214984930
Pubmed

TGF-β₂ decreases baseline and IL-13-stimulated mucin production by primary human bronchial epithelial cells.

MUC5B MUC5AC

8.12e-06441223249391
Pubmed

Characterization of mouse muc6 and evidence of conservation of the gel-forming mucin gene cluster between human and mouse.

MUC5B MUC5AC

8.12e-06441212676567
Pubmed

Effects of the Helicobacter pylori Virulence Factor CagA and Ammonium Ion on Mucins in AGS Cells.

MUC5B MUC5AC

8.12e-06441229869461
Pubmed

Munc13-2-/- baseline secretion defect reveals source of oligomeric mucins in mouse airways.

MUC5B MUC5AC

8.12e-06441218258655
Pubmed

Investigation of killer cell immunoglobulin-like receptor (KIR) gene diversity: KIR2DL2, KIR2DL5 and KIR2DS5.

KIR2DL5A KIR2DL5B

8.12e-06441218498296
Pubmed

Polymorphism of human mucin genes in chest disease: possible significance of MUC2.

MUC5B MUC5AC

1.35e-05541211062147
Pubmed

A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.

SCN3A SCN9A

1.35e-0554128812438
Pubmed

Differential expression of MUC genes in endometrial and cervical tissues and tumors.

MUC5B MUC5AC

1.35e-05541216188033
Pubmed

Early development of electrical excitability in the mouse enteric nervous system.

SCN3A SCN9A

1.35e-05541222875929
Pubmed

Proteome-wide analysis of phospho-regulated PDZ domain interactions.

TANC1 ATP2B2 ADAM22

1.69e-054241330126976
Pubmed

A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.

SCN3A SCN9A

2.03e-05641223652591
Pubmed

Organization, sequence, chromosomal localization, and promoter identification of the mouse orphan nuclear receptor Nurr1 gene.

SCN3A SCN9A

2.03e-0564129143501
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

CEP170 NAV1 MAGEB2 TANC1 QSER1 MGA TEX2

2.16e-0573341734672954
Pubmed

Chromosomal organization of candidate genes involved in cholesterol gallstone formation: a murine gallstone map.

MUC5B MUC17 MUC5AC

2.38e-054741311208732
Pubmed

Pain without nociceptors? Nav1.7-independent pain mechanisms.

SCN3A SCN9A

2.84e-05741224440715
Pubmed

The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.

BPTF MLLT3 SETD1B KDM5C

3.55e-0515741430186101
Pubmed

Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.

BPTF TANC1 TEX2 CUX1 AGAP1 ENAH

3.71e-0553641615840001
Pubmed

Significant determinants of mouse pain behaviour.

SCN3A SCN9A

3.78e-05841225101983
Pubmed

Exchangeable gene trap using the Cre/mutated lox system.

BPTF TANC1 TEX2 CUX1 AGAP1 ENAH

3.78e-0553841610512203
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

PER1 CEP170 BPTF ZSWIM8 TANC1 MGA ZNF827 KDM5C

4.08e-05111641831753913
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

PER1 CEP170 NAV1 DCLK2 NYAP2 TEX2 ADAM22 ENAH

4.72e-05113941836417873
Pubmed

Genetic mapping of the peripheral sodium channel genes, Scn9a and Scn10a, in the mouse.

SCN3A SCN9A

4.86e-0594128854872
Pubmed

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.

SCN3A SCN9A

4.86e-05941216382098
Pubmed

Interaction network of human early embryonic transcription factors.

BPTF QSER1 MGA ASXL3 TLE3

5.66e-0535141538297188
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

PER1 BPTF QSER1 MGA KDM5C TLE3 CUX1

5.83e-0585741725609649
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

NAV1 ZSWIM8 TANC1 SETD1B EYA3 KDM5C

6.19e-0558841638580884
Pubmed

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.

CEP170 NAV1 MGA SCN9A

6.59e-0518441432908313
Pubmed

Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study.

MUC5B MUC5AC

7.41e-051141224429156
Pubmed

The Tbx20-TLE interaction is essential for the maintenance of the second heart field.

ATP2B2 TLE3

7.41e-051141237756602
Pubmed

Coexpression of Cux-1 and Notch signaling pathway components during kidney development.

TLE3 CUX1

7.41e-051141215499562
Pubmed

Af9/Mllt3 interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of the cerebral cortex.

MLLT3 TLE3

8.88e-051241220348416
Pubmed

Genome-wide association study of lung function phenotypes in a founder population.

ASXL3 TLE3

8.88e-051241223932459
InteractionFOXJ2 interactions

QSER1 KDM5C TLE3 CUX1

1.98e-0581404int:FOXJ2
InteractionHNF1B interactions

BPTF QSER1 MGA TLE3 CUX1

3.56e-05190405int:HNF1B
InteractionFARP2 interactions

PER1 ZSWIM8 MAGEB2 MGA

3.57e-0594404int:FARP2
InteractionYWHAZ interactions

CEP170 NAV1 CCDC88C TANC1 CLIP1 ATP2B2 TEX2 ADAM22 ASXL3 AGAP1 ENAH

3.58e-0513194011int:YWHAZ
InteractionEN1 interactions

QSER1 MGA TLE3 CUX1

6.60e-05110404int:EN1
InteractionFOXK2 interactions

PER1 BPTF SETD1B ASXL3 CUX1

7.94e-05225405int:FOXK2
InteractionNFIX interactions

BPTF QSER1 MGA TLE3 CUX1

8.28e-05227405int:NFIX
InteractionH3-3A interactions

BPTF MLLT3 QSER1 SETD1B EYA3 MGA KDM5C CUX1

9.38e-05749408int:H3-3A
InteractionTERF2IP interactions

BPTF QSER1 EYA3 MGA KDM5C CUX1 ENAH

9.47e-05552407int:TERF2IP
InteractionWWTR1 interactions

CEP170 BPTF QSER1 CUX1 WDR44 ENAH

1.71e-04422406int:WWTR1
Cytoband2q24

SCN3A SCN9A

4.26e-05114122q24
CytobandEnsembl 112 genes in cytogenetic band chr2q24

TANC1 SCN3A SCN9A

2.04e-04127413chr2q24
GeneFamilyCD molecules|Mucins

MUC16 MUC5B MUC17 MUC5AC

4.15e-0821314648
GeneFamilySodium voltage-gated channel alpha subunits

SCN3A SCN9A

1.02e-0493121203
GeneFamilyCD molecules|Killer cell immunoglobulin like receptors

KIR2DL5A KIR2DL5B

4.28e-0418312620
GeneFamilyMAGE family

MAGEB2 MAGEC1

2.13e-03403121136
GeneFamilyPHD finger proteins

BPTF KDM5C

1.04e-029031288
CoexpressionJAATINEN_HEMATOPOIETIC_STEM_CELL_UP

CEP170 MLLT3 TANC1 QSER1 SCN3A PDZD2 SCN9A

5.32e-07323407M15107
CoexpressionGSE39152_SPLEEN_CD103_NEG_VS_BRAIN_CD103_POS_MEMORY_CD8_TCELL_DN

PER1 TEF CLIP1 TEX2 SCN3A

1.30e-05200405M9067
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HGABA

NAV1 MLLT3 DCLK2 CLIP1 ATP2B2 ASXL3 SCN3A AGAP1 SCN9A

3.44e-051106409M39071
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_k-means-cluster#3_top-relative-expression-ranked_1000

MLLT3 SETD1B ZNF827 KDM5C SCN3A PDZD2

5.02e-06243396gudmap_developingLowerUrinaryTract_e14.5_ urethra_1000_k3
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle F_emap-6706_k-means-cluster#1_top-relative-expression-ranked_1000

MLLT3 ASXL3 KDM5C CUX1 SCN3A

2.64e-05193395gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle F_1000_k1
CoexpressionAtlasdev lower uro neuro_e14.5_BladdPelvicGanglion_Sox10_k-means-cluster#3_top-relative-expression-ranked_1000

DCLK2 NYAP2 ADAM22 SCN3A SCN9A

3.28e-05202395gudmap_dev lower uro neuro_e14.5_BladdPelvicGanglion_Sox10_k3_1000
CoexpressionAtlasFacebaseRNAseq_e10.5_Maxillary Arch_top-relative-expression-ranked_2500_k-means-cluster#5

CEP170 BPTF QSER1 MGA CLIP1 ADAM22 ENAH

1.30e-04629397Facebase_RNAseq_e10.5_Maxillary Arch_2500_K5
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle F_emap-6706_k-means-cluster#3_top-relative-expression-ranked_100

CUX1 SCN3A

1.47e-0410392gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle F_100_k3
ToppCellControl-Epithelial_cells-Airway_mucous|Control / group, cell type (main and fine annotations)

MUC16 MUC5B MUC17 MUC5AC SCN3A AGAP1

1.22e-0818339615d24a4fb1ffe6cbafbd54fcd7dde9ddcfbe03b2
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MUC16 MUC5B TANC1 CMYA5 MUC5AC

4.86e-071793956e965e424eebef50f0202cff75f458be395cfca1
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MLLT3 EYA3 ADAM22 ASXL3 SCN3A

6.53e-071903954836ea19308d2a96694f12ab0653b7ce7b101d2f
ToppCell3'_v3-Lung-Lymphocytic_T_CD4-T_CD4/CD8|Lung / Manually curated celltypes from each tissue

CCDC88C MLLT3 ZNF827 ADAM22

9.15e-06151394999c11d19b61d6b130ad5e623afa83cbdfe13cdd
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MUC16 AXDND1 MUC5B MUC5AC

1.07e-05157394c43f2e1ea53b375a7432f17f87cfef3b2261003d
ToppCellAdult-Epithelial-lung_goblet_cell-D231|Adult / Lineage, Cell type, age group and donor

MUC16 MUC5B MUC5AC ASXL3

1.60e-051743947d2f802f493f19a068e097b2909a9000e2160266
ToppCellnucseq-Epithelial-Epithelial_Glandular|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MUC16 MUC5B MUC17 MUC5AC

1.79e-05179394859cd8ee414ad6207c046ada2e655e49322dd01c
ToppCellnucseq-Epithelial-Epithelial_Glandular-Goblet|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MUC16 MUC5B MUC17 MUC5AC

1.83e-051803943dc80bc636bf0e6ffc9762853132a9fe59fd1f66
ToppCellnucseq-Epithelial-Epithelial_Glandular-Goblet-Goblet|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MUC16 MUC5B MUC17 MUC5AC

1.83e-05180394668a2d8e1d5a390309d5eb62c836f5903144bea9
ToppCellPCW_05-06-Epithelial-Epithelial_neuroendo-epi_neuroendocrine2[NE2]_(12)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

MUC5B NYAP2 MUC5AC SCN3A

1.91e-05182394dc29e8735c3562ce32322351d28f7d9709208ebf
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CCDC88C EYA3 ADAM22 SCN3A

1.95e-05183394b5ede5a0048c585b73c00e88aeddbcaf669347b1
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Degenerative_Connecting_Tubule_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MLLT3 EYA3 ADAM22 SCN3A

1.99e-051843949690d4290e70f9bda889754ffb30b0af1f7cb94b
ToppCellControl-Epithelial_cells-Airway_goblet|Control / group, cell type (main and fine annotations)

MUC16 MUC5B MUC17 MUC5AC

1.99e-05184394d92a71441e4e19f8c301999d8186f8e48e3cd162
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)-Goblet_(bronchial)_L.0.4.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MUC16 MUC5B CMYA5 MUC5AC

1.99e-0518439401c19a830348ab0b9c02c1546a439de70ee10f97
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L3-4_RORB_RPS3P6|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TANC1 CMYA5 CUX1 SCN9A

2.03e-0518539410da5c2a92bfb3248d3f6f94a0933996326cf590
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MLLT3 EYA3 ADAM22 SCN3A

2.08e-05186394d65fa6d8e8a195ea10cfde1499d096d6acf7a634
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Degenerative_Connecting_Tubule_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MLLT3 EYA3 ADAM22 SCN3A

2.08e-05186394b3358e0fa6d845c81e94d56c8575f016621d28ff
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CCDC88C EYA3 ADAM22 SCN3A

2.12e-051873942d17408b3b5f09d135084fd7ccce98e6b5ca632b
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CCDC88C EYA3 ADAM22 SCN3A

2.12e-05187394e3095455d2f255854f339f6b05fa87852af0700f
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MLLT3 EYA3 ADAM22 SCN3A

2.17e-051883944154f4787483c7e076e87a187733a9f666742c3d
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CCDC88C EYA3 ADAM22 SCN3A

2.21e-051893943a295c215b5c18e7c673f92b7af5be523421682c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MLLT3 EYA3 ADAM22 SCN3A

2.21e-051893948ff3c3232eff9de4b5c9b22ecb82bc509d773f58
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CCDC88C EYA3 ADAM22 SCN3A

2.21e-05189394532aaf02b364c5c4f58a2021c7c21d86df3875c9
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MLLT3 EYA3 ADAM22 SCN3A

2.21e-0518939490aae7e806882bebfad78a78e9a16cf56af3ecd4
ToppCellCOVID-19-Epithelial_cells-Airway_goblet|COVID-19 / group, cell type (main and fine annotations)

MUC16 MUC5B MUC5AC AGAP1

2.26e-0519039451ca9ef4df3220487152fcf684147730637c7cc1
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MUC16 MUC5B CMYA5 MUC5AC

2.26e-051903943c337374d89e69cc0a78e65a4a7e21db7b050fcd
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MUC16 MUC5B CMYA5 MUC5AC

2.26e-0519039423f2ac4da431211084bb6ab0494c2e0b69547cb6
ToppCellAdult-Epithelial|Adult / Lineage, Cell type, age group and donor

MLLT3 TANC1 AGAP1 PDZD2

2.35e-05192394efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCellControl-Epithelial-Club|Control / Disease state, Lineage and Cell class

MLLT3 TANC1 AGAP1 ENAH

2.35e-05192394d84ed1ea4a03edaa18c804f75afb03bd7b1f0e16
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Goblet|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MUC16 MUC5B MUC5AC ASXL3

2.45e-05194394e0228f593c3493175962a4817500d4337ddc4e88
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CCDC88C EYA3 ADAM22 SCN3A

2.45e-051943944d6c9b016e3a0641954a8ea10c97d1cd76fadd9f
ToppCellcontrol-immature_Neutrophil|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

PER1 AXDND1 QSER1 KDM5C

2.55e-05196394e34fd3e7a5b1c22a81fd3208e6d58bdb846d51c4
ToppCellCOVID-19-Epithelial-Club,_Basal_cells|COVID-19 / Condition, Lineage and Cell class

MUC16 MUC5B CMYA5 MUC5AC

2.55e-05196394dd32046067d93b9484cfbf1d7826a436a3d9f0e9
ToppCelldistal-Epithelial-Goblet|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MUC16 MUC5B CMYA5 MUC5AC

2.60e-05197394da1ed7303cc9cb2d205c0e5c49c52544d3540951
ToppCellCOVID-19-Epithelial-Club,_Basal_cells|Epithelial / Condition, Lineage and Cell class

MUC16 MUC5B CMYA5 MUC5AC

2.60e-0519739478ed2810e5a765327e7a6da0ca5d4854bf7a0b6f
ToppCellBronchus_Control_(B.)|World / Sample group, Lineage and Cell type

MUC16 MUC5B CMYA5 MUC5AC

2.60e-05197394b6dff2ee108813e18657e2d8cf850e2423f8c8e9
ToppCelldistal-Epithelial-Goblet-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MUC16 MUC5B CMYA5 MUC5AC

2.60e-051973943fbf456ae4f73da4f6254a6f0d24f0ec27d7a3cc
ToppCellBiopsy_Other_PF-Epithelial-MUC5AC+_High|Biopsy_Other_PF / Sample group, Lineage and Cell type

MUC16 MUC5B CMYA5 MUC5AC

2.65e-0519839430e6177e216f66caddcd009fafef0e07369f4d8e
ToppCellParenchymal-NucSeq|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations

TANC1 CUX1 AGAP1 PDZD2

2.65e-051983941996373bdccc55aac347d349bd22f6aad6d0c668
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_basal-Suprabasal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

MUC16 MUC5B CMYA5 ASXL3

2.65e-05198394de5987588b9fa9ee8c595ba06d7d844ead0e3c74
ToppCellBL-critical-LOC-Epithelial-Secretory_LYPD2|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

MUC16 MUC5B MUC5AC ENAH

2.65e-05198394484d16aaa601a1e11b871b0475dd01a2de1a29ce
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Newborn-35|World / Primary Cells by Cluster

CEP170 BPTF MLLT3 ENAH

2.65e-05198394de5214a85fe017eb23d4aa8af624464f062ec57e
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NAV1 CMYA5 PDZD2 SCN9A

2.71e-0519939419a97e27a4758e794ce7246d295e112b47931a48
ToppCellNeuron|World / Primary Cells by Cluster

CEP170 MLLT3 ASXL3 SCN3A

2.71e-051993941f8104fd92f04690b41d9d07ac08dc59d76bb97d
ToppCellNeuron-Postmitotic|World / Primary Cells by Cluster

CEP170 MLLT3 ASXL3 SCN3A

2.71e-051993941973527f8a7d4c6490d75c0d0ea153688166a08b
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Neuronal-Cortical_neuron|10w / Sample Type, Dataset, Time_group, and Cell type.

CEP170 NAV1 ASXL3 SCN3A

2.76e-0520039468c90376e2779434e4ad8dc6dd3b44baa700e2f4
ToppCellBronchus_Control_(B.)-Epithelial-TX-Club|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

MUC16 MUC5B CMYA5 MUC5AC

2.76e-05200394292c63693eb7f435335a8cfba07aa35b72139393
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW26-Neuronal-GABAergic_neurons|GW26 / Sample Type, Dataset, Time_group, and Cell type.

NYAP2 ASXL3 CUX1 SCN9A

2.76e-05200394bad32a95b759fad509401b07bc96a56687c2a592
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Neuronal|10w / Sample Type, Dataset, Time_group, and Cell type.

CEP170 NAV1 ASXL3 SCN3A

2.76e-05200394979258173b82f37aeaaedd53b4a527da1dbe1b80
ToppCellTracheal-NucSeq-Epithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MUC16 MUC5B TANC1 AGAP1

2.76e-05200394d3af0a706baf66e3f32e67b17dcfc31e5b32ce0e
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Intermediate|5w / Sample Type, Dataset, Time_group, and Cell type.

CEP170 NAV1 DCLK2 AGAP1

2.76e-05200394c92e4fc0442404481fcac623d691dae6215b852d
ToppCellBronchus_Control_(B.)-Epithelial-TX|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

MUC16 MUC5B MUC5AC ENAH

2.76e-05200394f5bc7d30aa03dd0f95eb64255bd1a2543be8d327
ToppCellP15-Epithelial-epithelial_progenitor_cell-epithelial_progenitor_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CCDC88C AXDND1 MUC5B

2.86e-04147393aba44c7057096483c4293a7ebcf8ccc8baed0231
ToppCellClub_cells-Donor_03|World / lung cells shred on cell class, cell subclass, sample id

MLLT3 MUC5B MUC5AC

2.86e-041473935a824c89e4d045af465d7333275f8191fb29b041
ToppCellmetastatic_Brain-T/NK_cells-Naive_CD8+_T|T/NK_cells / Location, Cell class and cell subclass

TANC1 CMYA5 TEX2

2.86e-041473934f7a0c287721befeffabf95b8c5f9ff64149c7c1
ToppCellMS-CD4-CD8_2|MS / Condition, Cell_class and T cell subcluster

AXDND1 ADAM22 PDZD2

2.98e-0414939308fb6be5599c5988890c851ce5ac6781c319948e
ToppCellClub_cells-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

MUC5B MUC5AC ASXL3

2.98e-0414939381c813588bb5efb7b31141a75d387210dcb76094
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-3|TCGA-Brain / Sample_Type by Project: Shred V9

ZNF827 ASXL3 TLE3

2.98e-04149393768877bade04ca0321593b8470b5011ad8270431
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MLLT3 CMYA5 ADAM22

3.22e-0415339379c4f4ccdc8249c8461075c73491bc3b2d13344a
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MUC16 MUC5B MUC5AC

3.35e-0415539362b59cb32b12bd55b19e98786a866d788fc9e4bf
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NAV1 CMYA5 SCN3A

3.35e-0415539377fdae85d36efb776db977eb424b32487ef222e4
ToppCellsevere_COVID-19-cDC|severe_COVID-19 / disease group, cell group and cell class (v2)

NAV1 DCLK2 SCN9A

3.47e-04157393ec1978e07e2214048d015d8bb793c1d9991f6e37
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_2|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

TANC1 CMYA5 ENAH

3.47e-04157393b9d04ee417c0d8ea0801d10f1c54e138587009fd
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MUC16 MUC5B MUC5AC

3.60e-0415939360b1f4dce2ce0911160fda17f137c064da31e2eb
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MLLT3 CMYA5 ADAM22

3.60e-0415939350d951cf27a571c0c5002003c16fbc370fa17eb1
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Mesenchymal|GW19 / Sample Type, Dataset, Time_group, and Cell type.

TANC1 TEF SCN9A

3.60e-04159393f34f2729a3872fbb2939e76ad35d7e25f71b8f57
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Mesenchymal-Unfolded_protein_responsible_cell|GW19 / Sample Type, Dataset, Time_group, and Cell type.

TANC1 TEF SCN9A

3.60e-04159393929ed98f6c2ad14e8d5af5c6f11a5a3d4b388cf7
ToppCellBAL-Mild-cDC_5|Mild / Compartment, Disease Groups and Clusters

PER1 MUC16 DCLK2

3.74e-041613937a6e8ed0b5d999efce8945d8083ab01d71be9a92
ToppCellControl-Epithelial-Ionocyte|World / Disease state, Lineage and Cell class

MUC16 ASXL3 SCN9A

3.81e-04162393e3b9b46ce2faff7d099502df14bbf51e9f183f8c
ToppCellPND07-28-samps-Epithelial-Epithelial-non_alveolar-Club_cell|PND07-28-samps / Age Group, Lineage, Cell class and subclass

MUC5B CMYA5 ATP2B2

3.81e-04162393aed15eef32419b8a4e2afdb9776c2bf2802e96f1
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

EYA3 ADAM22 SCN3A

3.81e-04162393285e6d553f485fd9f1075c4e1b940da251b5ea35
ToppCellControl-Epithelial-Ionocyte|Control / Disease state, Lineage and Cell class

MUC16 ASXL3 SCN9A

3.88e-04163393bf09fa39bf3e6b3a776d5e79c30c96df572956a3
ToppCellfacs-Marrow-KLS-24m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZSWIM8 DCLK2 SCN3A

3.88e-04163393b83a35c4426d66b5734a98fa6c72b345fe462030
ToppCellfacs-Marrow-KLS-24m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZSWIM8 DCLK2 SCN3A

3.88e-04163393c20ca9b6b4170ebcb0e66eef3e5d8ebff22b1a91
ToppCellAdult-Epithelial-lung_goblet_cell-D175|Adult / Lineage, Cell type, age group and donor

MUC16 MUC5B MUC5AC

3.95e-041643936e6aedb61f8e195d52e028fdda750a29bb14e57e
ToppCellfacs-Marrow-KLS-24m-Lymphocytic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZSWIM8 DCLK2 TANC1

3.95e-04164393d2b5f51af7fcffddebe997ee302bacbd85d76852
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

EYA3 ADAM22 SCN3A

3.95e-041643936fb2136168f430babfeb81ca7e151ca7a8092ec4
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADAM22 ASXL3 SCN3A

4.02e-041653939bd332e5ede759a00a47728ea5558c215efdd77a
ToppCellMild-Myeloid-Mast-|Mild / Condition, Lineage, Cell class and cell subclass

DCLK2 TANC1 SCN9A

4.02e-0416539393d3909a0f5f43d473d5005c842d7d73e25eceed
ToppCellMild-Myeloid-Mast|Mild / Condition, Lineage, Cell class and cell subclass

DCLK2 TANC1 SCN9A

4.02e-041653935fa9552c37890c5cc7e672a47038aebba2413cb4
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-Goblet_(subsegmental)_L.0.4.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MUC16 MUC5B MUC5AC

4.16e-0416739331633899aae852873a4887e72c621474b0a51a33
ToppCell3'_v3-lymph-node_spleen-Hematopoietic_progenitors-Progenitor|lymph-node_spleen / Manually curated celltypes from each tissue

ASXL3 SCN3A SCN9A

4.16e-04167393cb396f3edb9e8fdc316091e8e193dbba50e0be0c
ToppCell5'-Adult-Appendix-Hematopoietic-Myeloid-Lymphoid_DC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NAV1 MUC16 ADAM22

4.16e-041673938b223333c0c7a85b5a1af6f2f5b12ee0d94357f6
ToppCellControl|World / group, cell type (main and fine annotations)

MUC5AC AGAP1 PDZD2

4.23e-04168393a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCellClub_cells-Donor_07|World / lung cells shred on cell class, cell subclass, sample id

MUC5B MUC5AC ASXL3

4.31e-0416939303b303af8a26c6ff196507fe24f5bd3d75d7b1af
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP2B2 SCN3A SCN9A

4.31e-0416939312bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

EYA3 CMYA5 ADAM22

4.38e-04170393928e42c51a7079c506f21c669c4e4c1a0df84d77
ToppCelldroplet-Thymus-nan-3m-Myeloid|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NAV1 SCN3A AGAP1

4.46e-0417139325493a4a7b636920e2cfd984542cc500709c9dcf
ToppCelldroplet-Thymus-nan-3m-Myeloid-professional_antigen_presenting_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NAV1 SCN3A AGAP1

4.46e-04171393508b41e3ad2638f9dd546d251b13ff60fc8c3207
ToppCellAT1-AT2_cells-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

MUC5B MUC5AC SCN3A

4.53e-041723930be41df5d35d818deb7316ac21c9366eb4b7bfd1
ToppCellBronchial_Brush-Epithelial-Ionocytes|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

DCLK2 SCN3A SCN9A

4.61e-04173393e1de849dcd96063136bdac87e050ddbd55cabdcc
ToppCelldroplet-Thymus-nan-3m-Myeloid-Macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NAV1 SCN3A AGAP1

4.61e-0417339363f03abca84ae021ff34ff34537838aa8a1ccd11
ToppCellChildren_(3_yrs)-Epithelial-lung_goblet_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

MUC16 MUC5B MUC5AC

4.61e-04173393464267a2ff3f5c387b6c9c6fa4dab135a221f448
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MUC16 MUC5B MUC5AC

4.61e-04173393e8afef5ae68983eb8d6515b43952636a47e9d3d4
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MUC16 MUC5B MUC5AC

4.61e-041733933aa1d28d4814798a772808ed29e1dbbdf92abd03
ToppCellfacs-SCAT-Fat-24m-Lymphocytic-T_cell|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCDC88C MLLT3 ZNF865

4.69e-041743936ca9433d398aa3b48ecdc522dd545119e7c77dd4
ToppCelldroplet-Marrow-nan-3m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TLE3 AGAP1 PDZD2

4.77e-04175393cf53a15bfb37b6019e7052ffdf594a9ac040900e
ToppCell(03)_Secretory-(4)_1wkpi|(03)_Secretory / shred by cell type and Timepoint

PER1 TEF MUC5AC

4.77e-0417539306b52f85baa31b55bb31477244892b6da79fe2c9
ToppCellfacs-Marrow-T_cells-18m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CMYA5 TEX2 SCN3A

4.85e-0417639374f851a398c7562dd713bc0d8d488c0037243112
ToppCellASK452-Endothelial-Lymphatic|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq

ADAM22 SCN3A WDR44

4.85e-04176393b4d280ecc07701d526f50d44c45ea91b3eeb00b1
DrugN-(2-methyl-3-(4-(4-(4-(trifluoromethoxy)benzyloxy)piperidin-1-yl)-1,3,5-triazin-2-ylamino)phenyl)acetamide

SCN3A SCN9A

9.48e-063412ctd:C561228
DrugThiamine hydrochloride [67-03-8]; Down 200; 11.8uM; MCF7; HT_HG-U133A

PER1 QSER1 CLIP1 ADAM22 KDM5C

2.43e-051934152894_DN
DrugSC 19220; Up 200; 10uM; MCF7; HT_HG-U133A

PER1 MUC5B QSER1 ADAM22 KDM5C

2.55e-051954157060_UP
DrugVerapamyl hydrochloride [152-11-4]; Down 200; 8.2uM; MCF7; HT_HG-U133A

PER1 CCDC88C MLLT3 QSER1 ADAM22

2.68e-051974155387_DN
Diseasekeratoconjunctivitis (is_marker_for)

MUC16 MUC5AC

5.10e-063392DOID:9368 (is_marker_for)
Diseasecortical surface area measurement

NAV1 CCDC88C MLLT3 NYAP2 QSER1 TEF CUX1 AGAP1 PDZD2

5.07e-051345399EFO_0010736
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN3A SCN9A

7.61e-0510392DOID:0111294 (implicated_via_orthology)
Diseasedry eye syndrome (is_marker_for)

MUC16 MUC5AC

7.61e-0510392DOID:10140 (is_marker_for)
DiseaseDravet syndrome (implicated_via_orthology)

SCN3A SCN9A

7.61e-0510392DOID:0080422 (implicated_via_orthology)
Diseasecholangiocarcinoma (is_marker_for)

MUC16 MUC5B MUC5AC

8.41e-0564393DOID:4947 (is_marker_for)
Diseasepulmonary fibrosis

MUC5B MUC5AC

9.29e-0511392EFO_0009448
Diseaseinterstitial lung disease

NAV1 MUC5B MUC5AC

9.64e-0567393EFO_0004244
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN3A SCN9A

1.11e-0412392DOID:0060170 (implicated_via_orthology)
DiseaseT-Cell Lymphoma

MGA ASXL3

2.02e-0416392C0079772
Diseasebody mass index, high density lipoprotein cholesterol measurement

NYAP2 CLIP1

2.87e-0419392EFO_0004340, EFO_0004612
Diseaseanxiety disorder (implicated_via_orthology)

SCN3A SCN9A

3.87e-0422392DOID:2030 (implicated_via_orthology)
DiseaseEpilepsy

ASXL3 KDM5C SCN9A

4.07e-04109393C0014544
DiseaseSjogren's syndrome (is_marker_for)

MUC16 MUC5AC

4.61e-0424392DOID:12894 (is_marker_for)
Diseaseunipolar depression, response to selective serotonin reuptake inhibitor

CUX1 PDZD2

4.61e-0424392EFO_0003761, EFO_0005658
Diseasebody fat percentage, high density lipoprotein cholesterol measurement

NYAP2 CLIP1

5.01e-0425392EFO_0004612, EFO_0007800
Diseasetriacylglycerol 58:10 measurement

TANC1 SCN9A

9.30e-0434392EFO_0010437
DiseaseCOVID-19 symptoms measurement

MUC5B MUC5AC

9.85e-0435392EFO_0600019
Diseasebody weight

BPTF MLLT3 MGA CLIP1 ASXL3 AGAP1 PDZD2

1.19e-031261397EFO_0004338
Diseasenon-alcoholic fatty liver disease

BPTF NYAP2 ZNF827

1.79e-03182393EFO_0003095
Diseasemetabolic syndrome

BPTF DCLK2 NYAP2

2.34e-03200393EFO_0000195
Diseasewaist circumference

NAV1 BPTF MLLT3 NYAP2

2.42e-03429394EFO_0004342
Diseasereticulocyte measurement

PER1 NYAP2 ZNF827 CLIP1 CUX1 PDZD2

2.42e-031053396EFO_0010700
Diseasetriglycerides in LDL measurement

BPTF NYAP2

2.51e-0356392EFO_0022320
Diseaseidiopathic pulmonary fibrosis

MUC5B MUC5AC

2.59e-0357392EFO_0000768
Diseaseinsomnia measurement

NAV1 ATP2B2 ASXL3 AGAP1

2.72e-03443394EFO_0007876
Diseasetriglycerides in small VLDL measurement

BPTF NYAP2

2.97e-0361392EFO_0022145
Diseasepancreatic ductal carcinoma (is_marker_for)

MUC5B MUC5AC

2.97e-0361392DOID:3587 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
SEVSTTSSTSKPPTG

CEP170

1126

Q5SW79
SVCSSPSISSTTSPK

AGAP1

501

Q9UPQ3
VSSESTPKTSASCSP

CUX1

1041

P39880
SSKSDSEQPSPASSS

MLLT3

371

P42568
NSTETLSPAKSPSSS

ADAM22

856

Q9P0K1
PSTKESDSTQTTTPS

BPTF

1631

Q12830
TDTSKSATSSSPGSP

ATP2B2

1221

Q01814
TSHTSKSSEPSKSPD

ASXL3

936

Q9C0F0
TTPTVTSSKATPFSS

MUC5B

2501

Q9HC84
TPTATSSKATSSSSP

MUC5B

3031

Q9HC84
PSSSSKTSDPLASKT

QSER1

1461

Q2KHR3
TSPSLSQTTPSKDTD

EYA3

261

Q99504
SSSSSPTEPSSKTGI

KIR2DL5A

221

Q8N109
SEPKTSSSPNLSSTS

MUC16

9776

Q8WXI7
SSQASTSTKSPSEDP

MAGEB2

96

O15479
SSTSSSLSKSSPESP

MAGEC1

836

O60732
SKPSETPPSSTSSSA

MGA

1846

Q8IWI9
TPKSTKSSSSSPTSP

DCLK2

331

Q8N568
STPSPTSSLSSEDKQ

CCDC88C

236

Q9P219
SSSSSPTEPSSKTGI

KIR2DL5B

221

Q8NHK3
TTESSKSTNSQSPSP

PER1

86

O15534
PKTSAAETPSSASDT

PDZD2

2546

O15018
TSSSPAQTTPSTTSK

MUC5AC

1856

P98088
SAPTSSTTSTPQTSK

MUC5AC

3456

P98088
DPSTKLSTSSETVSS

NYAP2

146

Q9P242
TPSTPLNSTSTSESK

AXDND1

6

Q5T1B0
APTSESSLSPSTTEK

CMYA5

646

Q8N3K9
DSEPVTSKASSTSTP

ENAH

476

Q8N8S7
TISSEKASSTPSSET

CLIP1

36

P30622
TTLFPSSTEDTSSPT

MUC17

126

Q685J3
TTSTETSSSPTTAKD

MUC17

2606

Q685J3
DTSTPVTTSTKASSS

MUC17

2836

Q685J3
TETASPSIKSSTSSS

NAV1

1261

Q8NEY1
SSPEKTDATSSTTSP

SCN9A

1941

Q15858
KESASSSTASPPSSS

TEF

131

Q10587
PSSSTSASSTAKTPL

TANC1

466

Q9C0D5
STTSPSSSASDKEEE

SETD1B

1056

Q9UPS6
SSSTTSPPSYDSVTK

SCN3A

1961

Q9NY46
KPKAEVPSSSSSSSS

ZNF865

86

P0CJ78
SPSPSQESLSSSKSD

WDR44

561

Q5JSH3
SPASVASSSSTPSSK

TLE3

286

Q04726
DRKTPSESNSPSSSS

ZNF827

956

Q17R98
SSAPETTSDSSPTLS

ZSWIM8

1146

A7E2V4
QKTSSSSPLSSPSKS

TEX2

156

Q8IWB9
SPSKSPILSSSASTS

TEX2

166

Q8IWB9
KPSPLASSSTASSTT

KDM5C

1171

P41229