Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

EPPK1 IGF2R ARAP3 PCNX3 POLG CSPG4 RTTN HPS6 EIF4G1 HELZ2 CHSY1 MAPKBP1 ARRDC2 CABLES1

3.45e-091105591435748872
Pubmed

Effects of insulin-like growth factors-IR and -IIR antisense gene transfection on the biological behaviors of SMMC-7721 human hepatoma cells.

IGF2-AS IGF2R

8.48e-06359212603530
Pubmed

HIV- 1 protease inhibits Cap- and poly(A)-dependent translation upon eIF4GI and PABP cleavage.

PABPC4 EIF4G1

2.82e-05559219956697
Pubmed

Functional proteomics mapping of a human signaling pathway.

SUMF2 NPR1 RBBP6 WWP2 CSPG4 PABPC4 EIF4G1

6.27e-0559159715231748
Pubmed

A large-scale candidate gene association study of age at menarche and age at natural menopause.

BMP3 FMO3 IGF2R MCHR1 POLG

1.05e-0427559520734064
Pubmed

ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that is downregulated in breast cancer.

PCNX3 WWP2

1.54e-041159234927784
Pubmed

Multiple interactions between the ESCRT machinery and arrestin-related proteins: implications for PPXY-dependent budding.

WWP2 ARRDC2

1.54e-041159221191027
Pubmed

Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.

TGM1 SUMF2 MAP7D1 POLG IQSEC2 ZNF185 EIF4G1 TERT

1.62e-0492559828986522
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

MAP7D1 PCNX3 RBBP6 SCAF8 PABPC4 EIF4G1 HELZ2 ZHX1 HEXIM1 PPP1R12C

1.94e-041497591031527615
Pubmed

Mammalian α arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with β arrestins.

WWP2 ARRDC2

2.93e-041559223236378
Pubmed

Comparison of expression patterns between CREB family transcription factor OASIS and proteoglycan core protein genes during murine tooth development.

CSPG4 CREB3L1

4.25e-041859212684764
Pubmed

LukS-PV inhibits hepatocellular carcinoma cells migration by downregulating HDAC6 expression.

EPPK1 IQSEC2 PABPC4 ZNF185 EIF4G1 EPS8L3

4.47e-0458059635676659
Pubmed

A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes.

MAP7D1 WWP2 PCCA

4.59e-048859327182664
Pubmed

Dynamic Expression of Genes Involved in Proteoglycan/Glycosaminoglycan Metabolism during Skin Development.

BMP3 SUMF2 CHSY1

4.91e-049059330228991
Pubmed

BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A.

SUMF2 RBBP6 HPS6 PLBD2 PPP1R12C

7.27e-0441959533001583
Pubmed

Functional Characterization of DNA Methylation in the Oligodendrocyte Lineage.

GPR37 CSPG4

7.62e-042459227149841
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

C15orf62 ARHGAP6 EPPK1 RBBP6 ZHX1

8.17e-0443059535044719
Pubmed

Characterization of gene regulation and protein interaction networks for Matrin 3 encoding mutations linked to amyotrophic lateral sclerosis and myopathy.

EPPK1 PABPC4 EIF4G1

8.57e-0410959329511296
Pubmed

La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1).

PABPC4 HPS6 EIF4G1

8.80e-0411059325940091
Pubmed

Protein translation rate determines neocortical neuron fate.

PABPC4 EIF4G1

9.66e-042759238849354
Pubmed

WWP2 is an E3 ubiquitin ligase for PTEN.

WWP2 PCCA

1.12e-032959221532586
Pubmed

Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.

BMP3 PCCA

1.12e-032959223396134
Pubmed

Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef.

EIF4G1 CABLES1 C16orf54

1.49e-0313259326439863
Pubmed

Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia.

TGM1 XIRP1 EIF4G1 ZHX1

1.54e-0329259412819125
GeneFamilyRNA binding motif containing

SCAF8 PABPC4 CPEB3

6.78e-03213333725
GeneFamilyAnkyrin repeat domain containing

ARAP3 PPP1R12C ANKRD53

9.61e-03242333403
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-Interstitial_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGM1 SCAF8 CPEB3 MAPKBP1 CABLES1

3.64e-061795856eb84fe9691ad40127b2d1f1c672428333c8fab4
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-lung_macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGM1 SCAF8 CPEB3 MAPKBP1 CABLES1

3.64e-061795852c3abd646d2c8992e8ff76a824eab5beba8ba4c6
ToppCellHippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1-Endothelial_Tip.Dcn.Agt_(Agt)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

SLC22A6 IGF2-AS PYROXD2 KLHDC7A

2.90e-051355844cb399620aa9edc2ca59e4df76ab7011ceb58db9
ToppCellHippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_2|Hippocampus / BrainAtlas - Mouse McCarroll V32

SLC22A6 IGF2-AS PYROXD2 KLHDC7A

2.90e-051355846bd2a0bfd8d20950f1b66810668682dc055a0ada
ToppCellHippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1|Hippocampus / BrainAtlas - Mouse McCarroll V32

SLC22A6 IGF2-AS PYROXD2 KLHDC7A

2.90e-051355847e3559ed0fef7916d1938b4e1a9fa4456a60e3d3
ToppCellHippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1-Endothelial_Tip.Dcn.Agt_(Agt)|Hippocampus / BrainAtlas - Mouse McCarroll V32

SLC22A6 IGF2-AS PYROXD2 KLHDC7A

2.90e-0513558497989546826bf3739e1b86a10832a457fd37c5d2
ToppCellFrontal_cortex-Endothelial-MURAL|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

XIRP1 CSPG4 HRCT1 C6orf141

4.49e-051515847570372a315bc312ff57bb5f483375c401ae8787
ToppCellFrontal_cortex-Endothelial-MURAL-M1(Rgs5Acta2)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

XIRP1 CSPG4 HRCT1 C6orf141

4.49e-05151584527059e47e381b2f6d63c1abb39bc0795ee3829d
ToppCellfacs-Aorta-Heart-24m-Mesenchymal|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC22A6 PYROXD2 C11orf86 C16orf54

4.61e-051525841da25f913b0fb167f66e539aef509ca44893a878
ToppCellfacs-Aorta-Heart-24m-Mesenchymal-nan|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC22A6 PYROXD2 C11orf86 C16orf54

4.61e-05152584254f92d9e6c9c6404f3875dd54d655af87854b14
ToppCellSubstantia_nigra-Endothelial-ENDOTHELIAL_TIP|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

SLC22A6 IGF2-AS KLHDC7A CREB3L1

5.49e-05159584cb2470b288c13e454a2a80115b0d5613b3f718e6
ToppCell3'-GW_trimst-2-SmallIntestine-Epithelial-Tuft-related-Tuft|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CDC42BPG EPPK1 EPS8L3 KLHDC7A

6.34e-0516558434fd00be2b28716c871ad9fb356de84a299a0c01
ToppCelldroplet-Kidney-nan-18m-Epithelial-Epcam____brush_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGM1 IGF2-AS RADX CREB3L1

6.64e-05167584ed7e785dcd25777f64e0c2596ada4f5a5ea17121
ToppCelldroplet-Kidney-nan-18m-Epithelial-brush_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGM1 IGF2-AS RADX CREB3L1

6.96e-05169584f00741203efa0b948db7223ee8c19bdd0918258a
ToppCellfacs-Aorta-Heart-24m-Mesenchymal-fibroblast_of_cardiac_tissue|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC22A6 CSPG4 PYROXD2 C11orf86

6.96e-05169584daed9083ee05c220365200328c2c50047fe21efd
ToppCellCOVID-19_Moderate-NK_CD56bright|World / disease group, cell group and cell class

FMO3 PYROXD2 EPS8L3 CABLES1

7.12e-05170584caa6a534c1e9639caced9a51680f5c905f061bcc
ToppCellfacs-Heart-RV-24m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CSPG4 HPS6 HRCT1 C11orf86

7.96e-05175584bfac175b79bb7d3d81074a2407c206a7647ee75d
ToppCellfacs-Heart-RV-24m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CSPG4 HPS6 HRCT1 C11orf86

7.96e-05175584c94fb35bbac95123201ca87ca835aecaefc0c490
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Epithelial-neuroepithelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP3 SLC22A6 C6orf141 CREB3L1

9.07e-05181584c26d3cbbc592299786d79d1b15fc6bead2aafb9a
ToppCell10x5'-bone_marrow-Lymphocytic_B-Pre-B|bone_marrow / Manually curated celltypes from each tissue

C15orf62 BMP3 LINC00472 TERT

9.27e-05182584a5fd392178c2f533e265d2e3ce63b90c2553e4c1
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

HELZ2 CPEB3 MAPKBP1 ARRDC2

1.01e-0418658477bebf576eb9b96ecb4fefb8a82a31aaaa917fc0
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

HELZ2 CPEB3 MAPKBP1 ARRDC2

1.01e-0418658413bc41c60fd628af31899a5e8b480e06cc4781be
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal-Pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

XIRP1 CSPG4 C6orf141 PPP1R12C

1.23e-04196584184104cbea0461dd2757668ab9755948ac7b585a
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

XIRP1 CSPG4 C6orf141 PPP1R12C

1.23e-04196584bebb20dc210576101c317011e3afb59798f5d255
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal-brain_pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

XIRP1 CSPG4 C6orf141 PPP1R12C

1.23e-041965848114e98923096c54b6834f21550c3061bab6773d
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW12-Macroglial|GW12 / Sample Type, Dataset, Time_group, and Cell type.

XIRP1 CSPG4 HELZ2 ARRDC2

1.33e-04200584be1abe5bb1ce4e7dfec63af4ed0fc5b96bf77866
Drug2',3'-dideoxycytidine (ddC

SLC22A6 POLG ABCC11 TERT CREB3L1

1.45e-0676585CID000005718
Diseasemean arterial pressure

NPR1 ARAP3 PCNX3 PABPC4 TERT CREB3L1

3.26e-04499556EFO_0006340
DiseaseChloracne

TGM1 EPPK1

1.74e-0333552C0263454
Diseaseacute lymphoblastic leukemia (is_marker_for)

CSPG4 TERT

1.84e-0334552DOID:9952 (is_marker_for)
Diseasemultiple myeloma (is_marker_for)

IGF2R TERT

2.06e-0336552DOID:9538 (is_marker_for)
DiseaseLiver carcinoma

IGF2R CSPG4 CPEB3 EPS8L3 TERT

2.52e-03507555C2239176
Diseasetelomere length

TGM1 ARRDC2 TERT CABLES1

2.77e-03313554EFO_0004505

Protein segments in the cluster

PeptideGeneStartEntry
RLLGWGGGRARENEP

CEP295NL

136

Q96MC4
PREGLQRRQWGPLIG

ADGRF3

36

Q8IZF5
GGSQPWRPRLLREGN

BMP3

81

P12645
WEINPGGPAEQRPRD

CREB3L1

451

Q96BA8
RANRFWAGTLPPGEG

ARAP3

566

Q8WWN8
GPRWGQLVRAGQPAT

CSPG4

1171

Q6UVK1
QARRQRPGSPDPEWG

C16orf54

186

Q6UWD8
QGGQGPAPRRPWERG

NPR1

281

P16066
EPVGPGQRALWQGRA

ARRDC2

246

Q8TBH0
YQLGPGPGPWQRRIR

CDC42BPG

1206

Q6DT37
GLDWPNPERNRAGVP

RADX

16

Q6NSI4
WHSERGEGRGARPQP

ANKRD53

16

Q8N9V6
MRPNPRWQQGGRPQG

PABPC4

431

Q13310
FRLVGPGQWPGARNA

FMO3

471

P31513
AGVGLPWAQRARLQP

IQSEC2

286

Q5JU85
RWQSRAFPQLGGRPG

HEXIM1

46

O94992
TAAGGNRVRRAQPWP

HRCT1

46

Q6UXD1
RRGPAANQPGWRGEL

PCNX3

546

Q9H6A9
RLGGLQPGQDRWRGP

EPS8L3

156

Q8TE67
GPWSQQERNPEAPGR

ABCC11

41

Q96J66
LVAAGRRGRWPPQQL

PCCA

11

P05165
WRSPGQRARPAGRPA

POM121L12

151

Q8N7R1
VRINTARPGGGRPGW

RBBP6

491

Q7Z6E9
GGPNGIFASPRRWLQ

ARHGAP6

161

O43182
STRRQPGPQRGRWGL

LINC00472

86

Q9H8W2
WRGFRGAQQERAQPP

IGF2-AS

6

Q6U949
PTVIQRRGRDAWGPG

GPR37

46

O15354
GAGRASGEQWQPPRP

CABLES1

171

Q8TDN4
RSSREGQPGERWGPA

C6orf141

196

Q5SZD1
SNPWGGLQAGRDPRR

CPEB3

256

Q8NE35
RGSNWVPRRGDQGPK

EIF4G1

986

Q04637
WGRAGASLARGPQPD

MAP7D1

336

Q3KQU3
CAPGQGGRRWRLPQP

MCHR1

36

Q99705
AANPGPRRRGRWVQP

MAPKBP1

846

O60336
QSRPWPGRRDPQKGR

DUX1

81

O43812
RPAPAQRWGGNGQAE

KLHDC7A

41

Q5VTJ3
AQRRRWPPRGTQAGA

HELZ2

956

Q9BYK8
RGPGAELERAWPAGQ

HPS6

61

Q86YV9
DPRSGPWNRGFGQEV

SCAF8

1131

Q9UPN6
GGLEVWLPRDRQGQP

SLC22A6

61

Q4U2R8
WGRDFLQRPGRQPQA

LILRA3

261

Q8N6C8
NLGRVRDGPQWRDGI

IGF2R

1436

P11717
VGRTGQRPRGDGQDW

RTTN

316

Q86VV8
GDAWRGRGAPQRRAP

POLG

111

A0A3B3IS91
WRQPAGPGSGIRERL

SUMF2

126

Q8NBJ7
LRQWGARAGAEPGPG

PPP1R12C

26

Q9BZL4
APGARPQLQDAWRGP

EPPK1

2581

P58107
RPQLQDAWRGPREPG

EPPK1

3121

P58107
RPQLQDAWRGPREPG

EPPK1

4186

P58107
RRRRWKEPGSGGPQN

SMG9

16

Q9H0W8
ARGDARGAQLWPPGS

CHSY1

61

Q86X52
QGRPDGRRLPLWGDE

C15orf62

56

A8K5M9
QEPWGRPQEGQLRRA

C11orf86

21

A6NJI1
ALPAGWEQRELPNGR

WWP2

301

O00308
PFPAWRRDNTEARGG

PYROXD2

16

Q8N2H3
PRGRPRGSKRINNWD

ZHX1

756

Q9UKY1
RRDVAGARGAPPAWG

nan

176

Q8N9P0
RSDVGRWGGNPLQPP

TGM1

6

P22735
AIPAPGGRWARDGQV

PLBD2

41

Q8NHP8
GGRWARDGQVPPASR

PLBD2

46

Q8NHP8
PQPGGGDVRAARWLF

XIRP1

146

Q702N8
RVGEAWQERPGAPRG

ZNF185

416

O15231
AWQDRPGAPRGGQGD

ZNF185

486

O15231
LGPQGWRLVQRGDPA

TERT

31

O14746