Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontransmembrane receptor protein kinase activity

EPHB3 EPHB4 BMPR1A IGF2R EPHA3

8.39e-0685655GO:0019199
GeneOntologyMolecularFunctioncysteine-type endopeptidase activity

USP34 SENP1 CASP2 SENP2 CTSH

8.88e-0686655GO:0004197
GeneOntologyMolecularFunctionendopeptidase activity

PCSK5 USP34 SENP1 ADAMTS3 ADAMTS9 CASP2 SENP2 CTSH F10

1.01e-05430659GO:0004175
GeneOntologyMolecularFunctionephrin receptor activity

EPHB3 EPHB4 EPHA3

3.07e-0519653GO:0005003
GeneOntologyMolecularFunctionextracellular matrix structural constituent

THSD4 FBLN2 FBN2 SPOCK2 MUC6 FBN3

3.35e-05188656GO:0005201
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF16 ZNF605 ZNF585A ZNF607 LMX1B ZNF184 GATA2 GATA6 ZFP28 ZNF578 ZNF217 ZNF518B ZKSCAN4 ZNF284 ZNF71

3.67e-0514126515GO:0000981
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZNF16 ZNF605 ZNF585A ZNF607 LMX1B ZNF184 GATA2 GATA6 ZFP28 ZNF578 ZNF217 ZNF518B ZKSCAN4 ZNF284 ZNF71

5.35e-0514596515GO:0000977
GeneOntologyMolecularFunctiontransmembrane receptor protein tyrosine kinase activity

EPHB3 EPHB4 IGF2R EPHA3

5.96e-0565654GO:0004714
GeneOntologyMolecularFunctionubiquitin-like protein-specific endopeptidase activity

SENP1 SENP2

1.04e-045652GO:0070137
GeneOntologyMolecularFunctionSUMO-specific endopeptidase activity

SENP1 SENP2

1.04e-045652GO:0070139
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

ZNF16 ZNF605 ZNF585A ZNF607 ZNF184 GATA2 GATA6 ZFP28 ZNF578 ZNF217 ZKSCAN4 ZNF284 ZNF71

1.57e-0412446513GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZNF16 ZNF605 ZNF585A ZNF607 ZNF184 GATA2 GATA6 ZFP28 ZNF578 ZNF217 ZKSCAN4 ZNF284 ZNF71

1.95e-0412716513GO:0000987
GeneOntologyMolecularFunctiondeSUMOylase activity

SENP1 SENP2

2.17e-047652GO:0016929
GeneOntologyMolecularFunctionpeptidase activity

PCSK5 USP34 SENP1 ADAMTS3 ADAMTS9 CASP2 SENP2 CTSH F10

2.55e-04654659GO:0008233
GeneOntologyMolecularFunctioncysteine-type peptidase activity

USP34 SENP1 CASP2 SENP2 CTSH

4.04e-04192655GO:0008234
GeneOntologyMolecularFunctionextracellular matrix constituent conferring elasticity

FBLN2 FBN2

6.74e-0412652GO:0030023
GeneOntologyMolecularFunctionstructural molecule activity conferring elasticity

FBLN2 FBN2

9.26e-0414652GO:0097493
GeneOntologyMolecularFunctiontransmembrane-ephrin receptor activity

EPHB3 EPHA3

1.07e-0315652GO:0005005
GeneOntologyMolecularFunctionlow-density lipoprotein particle receptor activity

VLDLR LRP1

1.22e-0316652GO:0005041
GeneOntologyMolecularFunctionprotein tyrosine kinase activity

EPHB3 EPHB4 IGF2R EPHA3

1.28e-03145654GO:0004713
GeneOntologyMolecularFunctionpeptidase regulator activity

EPPIN SPOCK2 R3HDML CTSH PROS1

1.50e-03257655GO:0061134
GeneOntologyMolecularFunctionapolipoprotein binding

VLDLR LRP1

1.91e-0320652GO:0034185
GeneOntologyMolecularFunctionlipoprotein particle receptor activity

VLDLR LRP1

2.11e-0321652GO:0030228
GeneOntologyMolecularFunctioncalcium ion binding

VLDLR FBLN2 FBN2 LRP1 SPOCK2 F10 FBN3 PROS1

2.88e-03749658GO:0005509
GeneOntologyMolecularFunctionpeptidase inhibitor activity

EPPIN SPOCK2 R3HDML PROS1

3.23e-03187654GO:0030414
GeneOntologyMolecularFunctiontransition metal ion binding

TYR DPYD ADAMTS3 ADAMTS9 SUPT4H1 DPF3 ZNF184 GATA2 GATA6 ZNF407

4.85e-0311896510GO:0046914
GeneOntologyMolecularFunctionzinc ion binding

ADAMTS3 ADAMTS9 SUPT4H1 DPF3 ZNF184 GATA2 GATA6 ZNF407

8.10e-03891658GO:0008270
GeneOntologyBiologicalProcessaorta morphogenesis

EPHB4 BMPR1A ADAMTS9 LRP1

7.35e-0641634GO:0035909
GeneOntologyBiologicalProcessblood vessel development

EPHB3 EPHB4 PCSK5 BMPR1A EREG THSD7A ADAMTS9 GATA2 GATA6 LRP1 CTSH PTGS2

2.07e-059296312GO:0001568
GeneOntologyBiologicalProcessvasculature development

EPHB3 EPHB4 PCSK5 BMPR1A EREG THSD7A ADAMTS9 GATA2 GATA6 LRP1 CTSH PTGS2

3.14e-059696312GO:0001944
GeneOntologyBiologicalProcessregulation of peptidase activity

SENP1 EPPIN CASP2 LRP1 SPOCK2 R3HDML CTSH PTGS2

3.16e-05406638GO:0052547
GeneOntologyBiologicalProcessblood vessel morphogenesis

EPHB3 EPHB4 BMPR1A EREG THSD7A ADAMTS9 GATA2 GATA6 LRP1 CTSH PTGS2

3.30e-058176311GO:0048514
GeneOntologyBiologicalProcessresponse to retinoic acid

WNT5B IGF2R GATA6 CTSH EPHA3

5.01e-05131635GO:0032526
GeneOntologyBiologicalProcessangiogenesis

EPHB3 EPHB4 BMPR1A EREG THSD7A ADAMTS9 GATA2 GATA6 CTSH PTGS2

5.26e-057086310GO:0001525
GeneOntologyBiologicalProcesscirculatory system development

EPHB3 EPHB4 PCSK5 BMPR1A EREG THSD7A ADAMTS9 GATA2 GATA6 LRP1 SENP2 CTSH PTGS2 EPHA3

9.10e-0514426314GO:0072359
GeneOntologyBiologicalProcessaorta development

EPHB4 BMPR1A ADAMTS9 LRP1

1.05e-0480634GO:0035904
GeneOntologyBiologicalProcessregulation of cell motility

WNT5B PCSK5 BMPR1A FBN2 EPPIN ADAMTS9 GATA2 LRP1 SPOCK2 CTSH F10 PTGS2 EPHA3

1.08e-0412806313GO:2000145
GeneOntologyBiologicalProcessregulation of locomotion

WNT5B PCSK5 BMPR1A FBN2 EPPIN ADAMTS9 GATA2 LRP1 SPOCK2 CTSH F10 PTGS2 EPHA3

1.55e-0413276313GO:0040012
GeneOntologyBiologicalProcessartery morphogenesis

EPHB4 BMPR1A ADAMTS9 LRP1

1.81e-0492634GO:0048844
GeneOntologyBiologicalProcessregulation of transforming growth factor beta production

BMPR1A GATA6 PTGS2

1.96e-0437633GO:0071634
GeneOntologyBiologicalProcessembryo implantation

PCSK5 FBN2 APLF PTGS2

2.21e-0497634GO:0007566
GeneOntologyBiologicalProcesscell-substrate adhesion

EPHB3 PCSK5 FBLN2 ADAMTS9 LRP1 SPOCK2 EPHA3

2.47e-04410637GO:0031589
GeneOntologyBiologicalProcesstransforming growth factor beta production

BMPR1A GATA6 PTGS2

2.48e-0440633GO:0071604
GeneOntologyBiologicalProcessregulation of transforming growth factor beta2 production

BMPR1A GATA6

2.54e-048632GO:0032909
GeneOntologyBiologicalProcesstransforming growth factor beta2 production

BMPR1A GATA6

2.54e-048632GO:0032906
GeneOntologyBiologicalProcessregulation of hydrolase activity

EPHB3 SENP1 EPPIN CASP2 LRP1 SPOCK2 R3HDML CTSH PTGS2 EPHA3

3.06e-048786310GO:0051336
GeneOntologyBiologicalProcessatrioventricular node development

BMPR1A GATA6

3.26e-049632GO:0003162
GeneOntologyBiologicalProcessprotein desumoylation

SENP1 SENP2

3.26e-049632GO:0016926
GeneOntologyBiologicalProcessnegative regulation of peptidase activity

EPPIN LRP1 SPOCK2 R3HDML PTGS2

4.54e-04210635GO:0010466
GeneOntologyBiologicalProcessnegative regulation of proteolysis

SENP1 EPPIN LRP1 SPOCK2 R3HDML PTGS2

4.74e-04326636GO:0045861
GeneOntologyBiologicalProcesstube morphogenesis

EPHB3 EPHB4 BMPR1A EREG THSD7A ADAMTS9 GATA2 GATA6 LRP1 CTSH PTGS2

5.46e-0411256311GO:0035239
GeneOntologyBiologicalProcesspositive regulation of megakaryocyte differentiation

ZNF16 GATA2

5.94e-0412632GO:0045654
GeneOntologyBiologicalProcessephrin receptor signaling pathway

EPHB3 EPHB4 EPHA3

6.03e-0454633GO:0048013
GeneOntologyCellularComponentmicrofibril

THSD4 FBN2 FBN3

7.66e-0613643GO:0001527
GeneOntologyCellularComponentGolgi lumen

WNT5B PCSK5 MUC6 F10 PROS1

2.10e-05109645GO:0005796
GeneOntologyCellularComponentextracellular matrix

THSD4 WNT5B FBLN2 FBN2 ADAMTS3 ADAMTS9 SPOCK2 CTSH MUC6 FBN3

2.84e-056566410GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

THSD4 WNT5B FBLN2 FBN2 ADAMTS3 ADAMTS9 SPOCK2 CTSH MUC6 FBN3

2.91e-056586410GO:0030312
GeneOntologyCellularComponentcollagen-containing extracellular matrix

THSD4 WNT5B FBLN2 FBN2 ADAMTS3 ADAMTS9 SPOCK2 CTSH

2.06e-04530648GO:0062023
DomainGrowth_fac_rcpt_

EPHB3 EPHB4 PCSK5 VLDLR FBLN2 FBN2 LRP1 FBN3 EPHA3 PROS1

1.08e-101566310IPR009030
DomainEGF

PCSK5 VLDLR EREG FBLN2 FBN2 LRP1 ZNF578 F10 PTGS2 FBN3 PROS1

3.43e-102356311SM00181
DomainEGF_2

EPHB4 VLDLR EREG FBLN2 FBN2 LRP1 F10 PTGS2 FBN3 EPHA3 PROS1

1.22e-092656311PS01186
DomainEGF-like_dom

PCSK5 VLDLR EREG FBLN2 FBN2 LRP1 F10 PTGS2 FBN3 PROS1

1.02e-082496310IPR000742
DomainEGF-like_CS

EPHB4 VLDLR EREG FBLN2 FBN2 LRP1 F10 PTGS2 FBN3 PROS1

1.59e-082616310IPR013032
DomainEGF_Ca-bd_CS

VLDLR FBLN2 FBN2 LRP1 F10 FBN3 PROS1

3.57e-0897637IPR018097
DomainEGF_CA

VLDLR FBLN2 FBN2 LRP1 F10 FBN3 PROS1

4.12e-0899637PS01187
DomainASX_HYDROXYL

VLDLR FBLN2 FBN2 LRP1 F10 FBN3 PROS1

4.41e-08100637PS00010
DomainZnf_C2H2/integrase_DNA-bd

ZNF16 ZNF605 ZNF585A ZNF607 DPF3 ZNF184 ZFP28 ZNF407 ZNF578 ZNF217 ZNF518B ZKSCAN4 ZNF284 ZNF71

5.81e-086946314IPR013087
DomainEGF-type_Asp/Asn_hydroxyl_site

VLDLR FBLN2 FBN2 LRP1 F10 FBN3 PROS1

6.62e-08106637IPR000152
DomainEGF_3

VLDLR EREG FBLN2 FBN2 LRP1 F10 PTGS2 FBN3 PROS1

8.89e-08235639PS50026
DomainEGF_CA

VLDLR FBLN2 FBN2 LRP1 F10 FBN3 PROS1

1.74e-07122637SM00179
DomainEGF_1

VLDLR EREG FBLN2 FBN2 LRP1 F10 PTGS2 FBN3 PROS1

1.78e-07255639PS00022
DomainEGF-like_Ca-bd_dom

VLDLR FBLN2 FBN2 LRP1 F10 FBN3 PROS1

1.95e-07124637IPR001881
DomainEGF

VLDLR EREG LRP1 F10 PTGS2 FBN3 PROS1

2.17e-07126637PF00008
DomainZINC_FINGER_C2H2_2

ZNF16 ZNF605 ZNF585A ZNF607 DPF3 ZNF184 ZFP28 ZNF407 ZNF578 ZNF217 ZNF518B ZKSCAN4 ZNF284 ZNF71

2.25e-077756314PS50157
DomainZINC_FINGER_C2H2_1

ZNF16 ZNF605 ZNF585A ZNF607 DPF3 ZNF184 ZFP28 ZNF407 ZNF578 ZNF217 ZNF518B ZKSCAN4 ZNF284 ZNF71

2.32e-077776314PS00028
DomainZnf_C2H2-like

ZNF16 ZNF605 ZNF585A ZNF607 DPF3 ZNF184 ZFP28 ZNF407 ZNF578 ZNF217 ZNF518B ZKSCAN4 ZNF284 ZNF71

3.12e-077966314IPR015880
Domain-

ZNF16 ZNF605 ZNF585A ZNF607 DPF3 ZNF184 ZFP28 ZNF407 ZNF578 ZNF217 ZKSCAN4 ZNF284 ZNF71

3.39e-0767963133.30.160.60
DomainZnf_C2H2

ZNF16 ZNF605 ZNF585A ZNF607 DPF3 ZNF184 ZFP28 ZNF407 ZNF578 ZNF217 ZNF518B ZKSCAN4 ZNF284 ZNF71

3.57e-078056314IPR007087
DomainZnF_C2H2

ZNF16 ZNF605 ZNF585A ZNF607 DPF3 ZNF184 ZFP28 ZNF407 ZNF578 ZNF217 ZNF518B ZKSCAN4 ZNF284 ZNF71

3.73e-078086314SM00355
DomainEGF_CA

VLDLR FBLN2 FBN2 LRP1 FBN3 PROS1

4.40e-0786636PF07645
Domainzf-C2H2_6

ZNF16 ZNF605 ZNF607 ZNF184 ZFP28 ZNF578 ZKSCAN4 ZNF284 ZNF71

1.02e-06314639PF13912
DomainEphrin_rec_like

EPHB3 EPHB4 PCSK5 EPHA3

1.41e-0625634SM01411
DomainTyr-kin_ephrin_A/B_rcpt-like

EPHB3 EPHB4 PCSK5 EPHA3

1.41e-0625634IPR011641
DomaincEGF

FBLN2 FBN2 LRP1 FBN3

1.66e-0626634IPR026823
DomaincEGF

FBLN2 FBN2 LRP1 FBN3

1.66e-0626634PF12662
Domainzf-C2H2

ZNF16 ZNF605 ZNF585A ZNF607 ZNF184 ZFP28 ZNF407 ZNF578 ZNF217 ZKSCAN4 ZNF284 ZNF71

2.91e-066936312PF00096
DomainEphrin_rec_like

EPHB3 EPHB4 EPHA3

5.92e-0611633PF07699
DomainRECEPTOR_TYR_KIN_V_2

EPHB3 EPHB4 EPHA3

1.30e-0514633PS00791
DomainRECEPTOR_TYR_KIN_V_1

EPHB3 EPHB4 EPHA3

1.30e-0514633PS00790
DomainEph_TM

EPHB3 EPHB4 EPHA3

1.30e-0514633IPR027936
DomainTyr_kinase_rcpt_V_CS

EPHB3 EPHB4 EPHA3

1.30e-0514633IPR001426
DomainEPH_lbd

EPHB3 EPHB4 EPHA3

1.30e-0514633SM00615
DomainEphrin_lbd

EPHB3 EPHB4 EPHA3

1.30e-0514633PF01404
DomainEphA2_TM

EPHB3 EPHB4 EPHA3

1.30e-0514633PF14575
DomainTyr_kinase_ephrin_rcpt

EPHB3 EPHB4 EPHA3

1.30e-0514633IPR016257
DomainEphrin_rcpt_lig-bd_dom

EPHB3 EPHB4 EPHA3

1.30e-0514633IPR001090
DomainEPH_LBD

EPHB3 EPHB4 EPHA3

1.30e-0514633PS51550
DomainKRAB

ZNF605 ZNF585A ZNF607 ZNF184 ZFP28 ZNF578 ZKSCAN4 ZNF284

2.60e-05358638PS50805
DomainKRAB

ZNF605 ZNF585A ZNF607 ZNF184 ZFP28 ZNF578 ZKSCAN4 ZNF284

2.60e-05358638PF01352
DomainKRAB

ZNF605 ZNF585A ZNF607 ZNF184 ZFP28 ZNF578 ZKSCAN4 ZNF284

3.23e-05369638SM00349
DomainKRAB

ZNF605 ZNF585A ZNF607 ZNF184 ZFP28 ZNF578 ZKSCAN4 ZNF284

3.29e-05370638IPR001909
DomainFBN

FBN2 FBN3

3.35e-053632IPR011398
DomainPLAC

THSD4 PCSK5 ADAMTS3

3.41e-0519633PS50900
DomainPLAC

THSD4 PCSK5 ADAMTS3

3.41e-0519633IPR010909
DomainTSP_1

THSD4 THSD7A ADAMTS3 ADAMTS9

6.03e-0563634PF00090
DomainADAM_spacer1

THSD4 ADAMTS3 ADAMTS9

6.17e-0523633IPR010294
DomainADAM_spacer1

THSD4 ADAMTS3 ADAMTS9

6.17e-0523633PF05986
DomainTSP1

THSD4 THSD7A ADAMTS3 ADAMTS9

6.82e-0565634SM00209
DomainTSP1_rpt

THSD4 THSD7A ADAMTS3 ADAMTS9

6.82e-0565634IPR000884
DomainTSP1

THSD4 THSD7A ADAMTS3 ADAMTS9

6.82e-0565634PS50092
Domain-

EPHB3 EPHB4 PCSK5 EPHA3

1.07e-04736342.60.120.260
DomainPeptidase_C48

SENP1 SENP2

2.33e-047632PF02902
DomainTB

FBN2 FBN3

2.33e-047632PF00683
DomainULP_PROTEASE

SENP1 SENP2

2.33e-047632PS50600
DomainPeptidase_C48_C

SENP1 SENP2

2.33e-047632IPR003653
DomainGalactose-bd-like

EPHB3 EPHB4 PCSK5 EPHA3

2.86e-0494634IPR008979
Domain-

FBN2 FBN3

3.09e-0486323.90.290.10
DomainTB

FBN2 FBN3

3.97e-049632PS51364
DomainTB_dom

FBN2 FBN3

3.97e-049632IPR017878
DomainZnF_GATA

GATA2 GATA6

7.23e-0412632SM00401
Domain-

F10 PROS1

7.23e-04126324.10.740.10
DomainCoagulation_fac_subgr_Gla_dom

F10 PROS1

7.23e-0412632IPR017857
DomainPkinase_Tyr

EPHB3 EPHB4 BMPR1A EPHA3

9.44e-04129634PF07714
DomainPLAC

THSD4 PCSK5

9.93e-0414632PF08686
DomainGla

F10 PROS1

9.93e-0414632PF00594
DomainLdl_recept_b

VLDLR LRP1

9.93e-0414632PF00058
DomainLDLRB

VLDLR LRP1

9.93e-0414632PS51120
DomainGLA

F10 PROS1

9.93e-0414632SM00069
DomainGLA_1

F10 PROS1

9.93e-0414632PS00011
DomainGLA_domain

F10 PROS1

9.93e-0414632IPR000294
DomainGLA_2

F10 PROS1

9.93e-0414632PS50998
DomainZnf_GATA

GATA2 GATA6

1.14e-0315632IPR000679
DomainGATA

GATA2 GATA6

1.14e-0315632PF00320
Domain-

GLIPR1L2 R3HDML

1.14e-03156323.40.33.10
DomainCAP

GLIPR1L2 R3HDML

1.14e-0315632PF00188
DomainCAP_domain

GLIPR1L2 R3HDML

1.14e-0315632IPR014044
DomainSCP

GLIPR1L2 R3HDML

1.14e-0315632SM00198
DomainAllrgn_V5/Tpx1

GLIPR1L2 R3HDML

1.14e-0315632IPR001283
DomainLY

VLDLR LRP1

1.14e-0315632SM00135
DomainLDLR_classB_rpt

VLDLR LRP1

1.14e-0315632IPR000033
DomainSer-Thr/Tyr_kinase_cat_dom

EPHB3 EPHB4 BMPR1A EPHA3

1.21e-03138634IPR001245
DomainGATA_ZN_FINGER_1

GATA2 GATA6

1.30e-0316632PS00344
DomainGATA_ZN_FINGER_2

GATA2 GATA6

1.30e-0316632PS50114
DomainPeptidase_M12B_ADAM-TS

ADAMTS3 ADAMTS9

2.95e-0324632IPR013273
DomainTyrKc

EPHB3 EPHB4 EPHA3

3.27e-0388633SM00219
DomainSAM

EPHB3 EPHB4 EPHA3

3.27e-0388633SM00454
DomainTyr_kinase_cat_dom

EPHB3 EPHB4 EPHA3

3.27e-0388633IPR020635
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

THSD4 THSD7A ADAMTS3 ADAMTS9 MUC6

5.92e-0668545M27303
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

THSD4 THSD7A ADAMTS3 ADAMTS9

1.43e-0539544M27417
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

THSD4 THSD7A ADAMTS3 ADAMTS9

1.43e-0539544MM15165
PathwayREACTOME_O_LINKED_GLYCOSYLATION

THSD4 THSD7A ADAMTS3 ADAMTS9 MUC6

5.90e-05109545MM15164
PathwayREACTOME_O_LINKED_GLYCOSYLATION

THSD4 THSD7A ADAMTS3 ADAMTS9 MUC6

6.43e-05111545M27416
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

THSD4 THSD7A ADAMTS3 ADAMTS9 MUC6

2.12e-04143545M27275
PathwayREACTOME_SUMO_IS_PROTEOLYTICALLY_PROCESSED

SENP1 SENP2

2.14e-046542M27225
PathwayREACTOME_SUMO_IS_PROTEOLYTICALLY_PROCESSED

SENP1 SENP2

2.99e-047542MM14928
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

FBLN2 FBN2 FBN3

3.76e-0437543M27134
PathwayREACTOME_TRANSPORT_OF_GAMMA_CARBOXYLATED_PROTEIN_PRECURSORS_FROM_THE_ENDOPLASMIC_RETICULUM_TO_THE_GOLGI_APPARATUS

F10 PROS1

5.10e-049542MM14614
PathwayREACTOME_GAMMA_CARBOXYLATION_OF_PROTEIN_PRECURSORS

F10 PROS1

5.10e-049542MM14613
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

FBLN2 FBN2 FBN3

6.30e-0444543M26969
PathwayREACTOME_PROCESSING_AND_ACTIVATION_OF_SUMO

SENP1 SENP2

6.35e-0410542M27235
PathwayREACTOME_REMOVAL_OF_AMINOTERMINAL_PROPEPTIDES_FROM_GAMMA_CARBOXYLATED_PROTEINS

F10 PROS1

6.35e-0410542M26977
PathwayREACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS

F10 PROS1

7.75e-0411542M12484
PathwayREACTOME_PROCESSING_AND_ACTIVATION_OF_SUMO

SENP1 SENP2

7.75e-0411542MM14937
PathwayREACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS

F10 PROS1

7.75e-0411542MM14615
PathwayREACTOME_EPH_EPHRIN_MEDIATED_REPULSION_OF_CELLS

EPHB3 EPHB4 EPHA3

9.72e-0451543M27311
PathwayBIOCARTA_EXTRINSIC_PATHWAY

F10 PROS1

1.09e-0313542M4470
PathwayWP_VITAMIN_K_METABOLISM_AND_ACTIVATION_OF_DEPENDENT_PROTEINS

F10 PROS1

1.09e-0313542M45518
PathwayBIOCARTA_EXTRINSIC_PATHWAY

F10 PROS1

1.09e-0313542MM1395
PathwayWP_FAMILIAL_HYPERLIPIDEMIA_TYPE_3

VLDLR LRP1

1.09e-0313542M42551
PathwayWP_SIDS_SUSCEPTIBILITY_PATHWAYS

VIPR1 LMX1B GATA2

1.48e-0359543MM15838
PathwayKEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS

DPYD BCAT1

1.67e-0316542M7528
Pubmed

Degenerate PCR-based cloning method for Eph receptors and analysis of their expression in the developing murine central nervous system and vasculature.

EPHB3 EPHB4 EPHA3

5.19e-07965311403717
Pubmed

Identification of an immediate early gene, pghs-B, whose protein product has prostaglandin synthase/cyclooxygenase activity.

GATA2 PTGS2

3.44e-0626521419907
Pubmed

The critical role of SENP1-mediated GATA2 deSUMOylation in promoting endothelial activation in graft arteriosclerosis.

SENP1 GATA2

3.44e-06265228569748
Pubmed

The SUMO proteases SENP1 and SENP2 play a critical role in nucleoporin homeostasis and nuclear pore complex function.

SENP1 SENP2

3.44e-06265224196834
Pubmed

Association of genetic variations of genes encoding thrombospondin, type 1, domain-containing 4 and 7A with low bone mineral density in Japanese women with osteoporosis.

THSD4 THSD7A

3.44e-06265218488137
Pubmed

SENP1 and SENP2 affect spatial and temporal control of sumoylation in mitosis.

SENP1 SENP2

3.44e-06265224048451
Pubmed

Cloning, characterization, and differential expression of MDK2 and MDK5, two novel receptor tyrosine kinases of the eck/eph family.

EPHB3 EPHB4

3.44e-0626527478528
Pubmed

Dysregulated expression of GATA2 and GATA6 transcription factors in adenomyosis: implications for impaired endometrial receptivity.

GATA2 GATA6

3.44e-06265237972693
Pubmed

Genetic Polymorphism of SUMO-Specific Cysteine Proteases - SENP1 and SENP2 in Breast Cancer.

SENP1 SENP2

3.44e-06265227178176
Pubmed

Clearance of coagulation factor VIII in very low-density lipoprotein receptor knockout mice.

VLDLR LRP1

3.44e-06265215327526
Pubmed

Aberrant GATA2 epigenetic dysregulation induces a GATA2/GATA6 switch in human gastric cancer.

GATA2 GATA6

3.44e-06265229106391
Pubmed

Genome-wide DNA methylation analysis predicts an epigenetic switch for GATA factor expression in endometriosis.

GATA2 GATA6

3.44e-06265224603652
Pubmed

Protein S binds to and inhibits factor Xa.

F10 PROS1

3.44e-0626528146182
Pubmed

Disruption of segmental neural crest migration and ephrin expression in delta-1 null mice.

EPHB3 EPHB4 EPHA3

4.16e-061765312217323
Pubmed

Ephrin-B2 and EphB1 mediate retinal axon divergence at the optic chiasm.

EPHB3 EPHB4 EPHA3

4.16e-061765312971893
Pubmed

PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development.

EPHB4 ADAMTS3 ADAMTS9 GATA2

4.68e-065965438374152
Pubmed

Expression of Ephs and ephrins in developing mouse inner ear.

EPHB3 EPHB4 EPHA3

5.91e-061965312684176
Pubmed

Multiple roles of EPH receptors and ephrins in neural development.

EPHB3 EPHB4 EPHA3

6.94e-062065311256076
Pubmed

The ephrins and Eph receptors in neural development.

EPHB3 EPHB4 EPHA3

6.94e-06206539530499
Pubmed

Eph receptors and ephrins: effectors of morphogenesis.

EPHB3 EPHB4 EPHA3

6.94e-062065310207129
Pubmed

The Eph family receptors and ligands.

EPHB3 EPHB4 EPHA3

6.94e-06206539576626
Pubmed

Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee.

EPHB3 EPHB4 EPHA3

8.09e-06216539267020
Pubmed

Eph receptors and ephrins demarcate cerebellar lobules before and during their formation.

EPHB3 EPHB4 EPHA3

8.09e-062165310495276
Pubmed

MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.

TYR VLDLR LRP1

8.09e-062165321337463
Pubmed

Developmental expression of Eph and ephrin family genes in mammalian small intestine.

EPHB3 EPHB4 EPHA3

8.09e-062165320112066
Pubmed

Roles of Eph receptors and ephrins in segmental patterning.

EPHB3 EPHB4 EPHA3

8.09e-062165311128993
Pubmed

Eph receptors and ephrins: regulators of guidance and assembly.

EPHB3 EPHB4 EPHA3

8.09e-062165310730216
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

FBN2 THSD7A LRP1 MUC6

9.82e-067165433541421
Pubmed

Activated protein C-dependent and -independent anticoagulant activities of protein S have different structural requirements.

F10 PROS1

1.03e-05365212490286
Pubmed

The binding sites for the very low density lipoprotein receptor and low-density lipoprotein receptor-related protein are shared within coagulation factor VIII.

VLDLR LRP1

1.03e-05365218277139
Pubmed

Overexpression of vasoactive intestinal peptide receptors and cyclooxygenase-2 in human prostate cancer. Analysis of potential prognostic relevance.

VIPR1 PTGS2

1.03e-05365222763881
Pubmed

Rare genetic variants in GATA transcription factors in patients with hypertrophic cardiomyopathy.

GATA2 GATA6

1.03e-05365228381408
Pubmed

Plasma protein S contains zinc essential for efficient activated protein C-independent anticoagulant activity and binding to factor Xa, but not for efficient binding to tissue factor pathway inhibitor.

F10 PROS1

1.03e-05365219244162
Pubmed

Association of rs1466535 LRP1 but not rs3019885 SLC30A8 and rs6674171 TDRD10 gene polymorphisms with abdominal aortic aneurysm in Italian patients.

LRP1 TDRD10

1.03e-05365224423473
Pubmed

The hepatic uptake of VLDL in lrp-ldlr-/-vldlr-/- mice is regulated by LPL activity and involves proteoglycans and SR-BI.

VLDLR LRP1

1.03e-05365218367731
Pubmed

The thrombin-sensitive region of protein S mediates phospholipid-dependent interaction with factor Xa.

F10 PROS1

1.03e-05365218784085
Pubmed

Two distinct sites in Nup153 mediate interaction with the SUMO proteases SENP1 and SENP2.

SENP1 SENP2

1.03e-05365222688647
Pubmed

The relationship among apolipoprotein(a) polymorphisms, the low-density lipoprotein receptor-related protein, and the very low density lipoprotein receptor genes, and plasma lipoprotein(A) concentration in the Czech population.

VLDLR LRP1

1.03e-05365211931574
Pubmed

Low Expression of EphB2, EphB3, and EphB4 in Bladder Cancer: Novel Potential Indicators of Muscular Invasion.

EPHB3 EPHB4

1.03e-05365234296545
Pubmed

Promotion of proliferation in the developing cerebral cortex by EphA4 forward signaling.

EPHB3 EPHB4 EPHA3

1.07e-052365319542359
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

THSD4 THSD7A ADAMTS3 ADAMTS9

1.22e-057565420637190
Pubmed

Eph receptors and their ephrin ligands are expressed in developing mouse pancreas.

EPHB3 EPHB4 EPHA3

1.23e-052465316446123
Pubmed

Identification of tyrosine kinases expressed in the male mouse gubernaculum during development.

EPHB3 EPHB4 EPHA3

1.39e-052565315254900
Pubmed

Bone morphogenetic proteins, eye patterning, and retinocollicular map formation in the mouse.

EPHB3 BMPR1A

2.06e-05465218614674
Pubmed

Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly.

FBN2 FBN3

2.06e-05465225034023
Pubmed

Eph receptor-ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro.

EPHB3 EPHA3

2.06e-0546529751130
Pubmed

SENP1 participates in the dynamic regulation of Elk-1 SUMOylation.

SENP1 SENP2

2.06e-05465220337593
Pubmed

Protein S enhances the tissue factor pathway inhibitor inhibition of factor Xa but not its inhibition of factor VIIa-tissue factor.

F10 PROS1

2.06e-05465218419747
Pubmed

The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor.

VLDLR LRP1

2.06e-05465215863833
Pubmed

Mediators of vascular remodelling co-opted for sequential steps in lung metastasis.

EREG PTGS2

2.06e-05465217429393
Pubmed

SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis.

SENP1 GATA2

2.06e-05465220457756
Pubmed

Effects of factor Xa and protein S on the individual activated protein C-mediated cleavages of coagulation factor Va.

F10 PROS1

2.06e-05465216935856
Pubmed

Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs.

SENP1 SENP2

2.06e-05465217591783
Pubmed

Histone modifications silence the GATA transcription factor genes in ovarian cancer.

GATA2 GATA6

2.06e-05465216607277
Pubmed

LDL receptor cooperates with LDL receptor-related protein in regulating plasma levels of coagulation factor VIII in vivo.

VLDLR LRP1

2.06e-05465215840700
Pubmed

Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells.

LMX1B LRP1 LSS

2.70e-053165319796621
Pubmed

Cloning of a complementary deoxyribonucleic acid encoding the murine homolog of the very low density lipoprotein/apolipoprotein-E receptor: expression pattern and assignment of the gene to mouse chromosome 19.

VLDLR LRP1

3.43e-0556528013374
Pubmed

Nucleus accumbens associated 1 is recruited within the promyelocytic leukemia nuclear body through SUMO modification.

SENP1 SENP2

3.43e-05565225891951
Pubmed

The transcription factor GATA-4 regulates cytochrome P4502C19 gene expression.

GATA2 GATA6

3.43e-05565220206639
Pubmed

Interaction between hex and GATA transcription factors in vascular endothelial cells inhibits flk-1/KDR-mediated vascular endothelial growth factor signaling.

GATA2 GATA6

3.43e-05565215016828
Pubmed

Critical Role of SREBP-1c Large-VLDL Pathway in Environment-Induced Hypertriglyceridemia of Apo AV Deficiency.

VLDLR LRP1

3.43e-05565230700132
Pubmed

GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A gene.

TYR GATA2

3.43e-0556521744088
Pubmed

Influence of single nucleotide polymorphisms on thrombin generation in factor V Leiden heterozygotes.

F10 PROS1

3.43e-05565224226152
Pubmed

Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor.

IGF2R RABEP1

3.43e-05565211387476
Pubmed

Normal sorting but defective endocytosis of the low density lipoprotein receptor in mice with autosomal recessive hypercholesterolemia.

VLDLR LRP1

3.43e-05565212746448
Pubmed

Apolipoprotein CI inhibits scavenger receptor BI and increases plasma HDL levels in vivo.

VLDLR LRP1

3.43e-05565218992221
Pubmed

Low levels of copper disrupt brain amyloid-β homeostasis by altering its production and clearance.

VLDLR LRP1

3.43e-05565223959870
Pubmed

Interaction of coagulation factor VIII with members of the low-density lipoprotein receptor family follows common mechanism and involves consensus residues within the A2 binding site 484-509.

VLDLR LRP1

3.43e-05565218685438
Pubmed

PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain.

PCSK5 VLDLR

5.13e-05665220453200
Pubmed

Zinc deficiency induces abnormal development of the myocardium by promoting SENP5 overexpression.

SENP1 SENP2

5.13e-05665233211757
Pubmed

SUMO-mimicking peptides inhibiting protein SUMOylation.

SENP1 SENP2

5.13e-05665225412743
Pubmed

Apolipoprotein CI causes hypertriglyceridemia independent of the very-low-density lipoprotein receptor and apolipoprotein CIII in mice.

VLDLR LRP1

5.13e-05665216478678
Pubmed

Quantitative genetic analysis of brain copper and zinc in BXD recombinant inbred mice.

EPHA3 PROS1

5.13e-05665216910173
Pubmed

Quantitative genetics of age-related retinal degeneration: a second F1 intercross between the A/J and C57BL/6 strains.

GATA2 APLF

5.13e-05665217277741
Pubmed

Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature.

EPHB3 EPHB4 EPHA3

6.79e-054265311439183
Pubmed

Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors.

GATA2 GATA6

7.18e-05765211724781
Pubmed

Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis.

EPHB3 EPHB4

7.18e-0576529990854
Pubmed

Similarities and Differences in the Way Transmembrane-Type Ligands Interact with the Elk Subclass of Eph Receptors.

EPHB3 EPHB4

7.18e-0576528954633
Pubmed

The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor.

VLDLR LRP1

7.18e-05765212169628
Pubmed

The Secreted Glycoprotein Reelin Suppresses the Proliferation and Regulates the Distribution of Oligodendrocyte Progenitor Cells in the Embryonic Neocortex.

VLDLR ADAMTS3

7.18e-05765232913108
Pubmed

GATA factors and androgen receptor collaborate to transcriptionally activate the Rhox5 homeobox gene in Sertoli cells.

GATA2 GATA6

7.18e-05765218212046
Pubmed

Specific and ubiquitous expression of different Zn finger protein genes in the mouse.

ZNF585A ZFP28

7.18e-0576523143103
Pubmed

Low density lipoprotein receptor-related protein 1 (LRP1) modulates N-methyl-D-aspartate (NMDA) receptor-dependent intracellular signaling and NMDA-induced regulation of postsynaptic protein complexes.

VLDLR LRP1

7.18e-05765223760271
Pubmed

SUMOylation of RNF146 results in Axin degradation and activation of Wnt/β-catenin signaling to promote the progression of hepatocellular carcinoma.

SENP1 SENP2

9.56e-05865237029301
Pubmed

Differential interactions of the homeodomain-interacting protein kinase 2 (HIPK2) by phosphorylation-dependent sumoylation.

SENP1 SENP2

9.56e-05865215896780
Pubmed

Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2.

VLDLR LRP1

9.56e-05865210380922
Pubmed

Gata6 restricts Isl1 to the posterior of nascent hindlimb buds through Isl1 cis-regulatory modules.

GATA2 GATA6

9.56e-05865229197504
Pubmed

Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3.

SENP1 SENP2

9.56e-05865216608850
Pubmed

Phospholipase C-related but catalytically inactive proteins regulate ovarian follicle development.

EREG PTGS2

9.56e-05865228360101
Pubmed

GATA6 is a crucial factor for Myocd expression in the visceral smooth muscle cell differentiation program of the murine ureter.

FBLN2 GATA2 GATA6

1.01e-044865335905011
Pubmed

Expression and requirement of T-box transcription factors Tbx2 and Tbx3 during secondary palate development in the mouse.

EPHB3 EPHB4 EPHA3

1.22e-045165319769959
Pubmed

Targeted inactivation of the mouse alpha 2-macroglobulin gene.

VLDLR LRP1

1.23e-0496527544347
Pubmed

EphrinB1 modulates glutamatergic inputs into POMC-expressing progenitors and controls glucose homeostasis.

EPHB3 EPHB4

1.23e-04965233253166
Pubmed

EphB/syndecan-2 signaling in dendritic spine morphogenesis.

EPHB3 EPHB4

1.23e-04965211580899
Pubmed

Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance.

VLDLR LRP1

1.23e-04965220005821
Pubmed

Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly.

EPHB3 EPHB4

1.53e-041065216413489
Pubmed

EphB signaling regulates target innervation in the developing and deafferented auditory brainstem.

EPHB3 EPHB4

1.53e-041065222021100
Pubmed

ADAMTS: a novel family of extracellular matrix proteases.

ADAMTS3 ADAMTS9

1.53e-041065211167130
Pubmed

EphB2 guides axons at the midline and is necessary for normal vestibular function.

EPHB3 EPHB4

1.53e-041065210839360
Pubmed

The transcription factor GATA-6 regulates pathological cardiac hypertrophy.

ADAMTS3 GATA6

1.53e-041065220705924
Cytoband4q13.3

EREG ADAMTS3

1.64e-03426524q13.3
Cytoband20q13.12

EPPIN R3HDML

3.31e-036065220q13.12
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF16 ZNF605 ZNF585A ZNF607 ZNF184 ZFP28 ZNF407 ZNF578 ZNF217 ZNF518B ZKSCAN4 ZNF284 ZNF71

5.00e-08718501328
GeneFamilyFibronectin type III domain containing|Sterile alpha motif domain containing|EPH receptors

EPHB3 EPHB4 EPHA3

7.09e-06145031095
GeneFamilySUMO specific peptidases

SENP1 SENP2

1.56e-047502984
GeneFamilyLow density lipoprotein receptors

VLDLR LRP1

5.73e-0413502634
GeneFamilyGla domain containing

F10 PROS1

5.73e-04135021250
GeneFamilyGATA zinc finger domain containing|Myb/SANT domain containing

GATA2 GATA6

7.69e-041550282
GeneFamilyADAM metallopeptidases with thrombospondin type 1 motif

ADAMTS3 ADAMTS9

1.24e-031950250
GeneFamilySterile alpha motif domain containing

EPHB3 EPHB4 EPHA3

1.85e-0388503760
GeneFamilyFibronectin type III domain containing

EPHB3 EPHB4 EPHA3

9.83e-03160503555
CoexpressionNABA_MATRISOME

THSD4 WNT5B PCSK5 EREG FBLN2 FBN2 ADAMTS3 ADAMTS9 SPOCK2 CTSH MUC6 F10 FBN3

9.66e-0710266413M5889
CoexpressionHE_LIM_SUN_FETAL_LUNG_C3_OMD_POS_ENDOTHELIAL_CELL

PCSK5 DPYD FBLN2 FBN2 GATA6 BCAT1 ZNF217 PTGS2

2.39e-06355648M45758
CoexpressionNABA_MATRISOME

THSD4 WNT5B PCSK5 EREG FBLN2 FBN2 ADAMTS3 ADAMTS9 SPOCK2 CTSH MUC6 F10

5.08e-0610086412MM17056
CoexpressionVART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN

EPHB3 EPHB4 WNT5B EREG EPHA3

2.01e-05135645M5825
CoexpressionAtlasDevelopingGonad_e16.5_epididymis_emap-29702_k-means-cluster#5_top-relative-expression-ranked_1000

PCSK5 VLDLR DPYD GATA2 LRP1 EPHA3

3.10e-05197656gudmap_developingGonad_e16.5_epididymis_1000_k5
CoexpressionAtlasratio_induced-Mesoderm_vs_StemCell_top-relative-expression-ranked_1000

EPHB3 VLDLR DPYD FBLN2 FBN2 ADAMTS9 LMX1B GATA2 GATA6 CTSH F10 PROS1

3.74e-059826512PCBC_ratio_MESO-5_vs_SC_1000
CoexpressionAtlasStromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4

BMPR1A FBLN2 LRP1 SPOCK2 CTSH PTGS2 EPHA3 PROS1

5.46e-05437658GSM777046_500
CoexpressionAtlasStromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3

BMPR1A FBLN2 ADAMTS9 GATA6 LRP1 PTGS2 EPHA3 PROS1

6.20e-05445658GSM777043_500
CoexpressionAtlasdev gonad_e13.5_M_InterstitFLeydig_MafB_top-relative-expression-ranked_1000

FBN2 IGF2R ADAMTS3 ADAMTS9 DPF3 GATA6 LRP1 LSS EPHA3 PROS1

1.13e-047736510gudmap_dev gonad_e13.5_M_InterstitFLeydig_MafB_1000
CoexpressionAtlasDevelopingGonad_e16.5_epididymis_emap-29702_top-relative-expression-ranked_1000

PCSK5 VLDLR DPYD FBLN2 FBN2 ADAMTS9 MIER3 GATA2 LRP1 EPHA3

1.35e-047906510gudmap_developingGonad_e16.5_epididymis_1000
CoexpressionAtlasratio_EmbryoidBody_vs_StemCell_top-relative-expression-ranked_500

EPHB3 ADAMTS9 LMX1B DPF3 GATA2 GATA6 PTGS2 EPHA3

1.35e-04498658PCBC_ratio_EB_vs_SC_500
CoexpressionAtlasDevelopingGonad_e14.5_ epididymis_emap-29141_top-relative-expression-ranked_1000

PCSK5 VLDLR FBLN2 IGF2R ADAMTS9 MIER3 GATA2 GATA6 LRP1 EPHA3

1.51e-048016510gudmap_developingGonad_e14.5_ epididymis_1000
CoexpressionAtlasdev gonad_e11.5_M_GonadVasMes_Flk_top-relative-expression-ranked_1000

EREG FBLN2 FBN2 IGF2R ADAMTS9 DPF3 CASP2 GATA6 LRP1 ZNF518B

1.95e-048276510gudmap_dev gonad_e11.5_M_GonadVasMes_Flk_1000
CoexpressionAtlasratio_EmbryoidBody_vs_StemCell_top-relative-expression-ranked_1000

EPHB3 WNT5B THSD7A ADAMTS9 LMX1B DPF3 GATA2 GATA6 SRL PTGS2 EPHA3

1.97e-049946511PCBC_ratio_EB_vs_SC_1000
ToppCellwk_20-22-Endothelial-Blood_vessel_endothelial-OMD+_endo|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

FBLN2 FBN2 GATA2 GATA6 BCAT1 PTGS2

2.24e-0717665652af8f717dbd3b59eeb868b8b7b256a8f3e57d7a
ToppCellCOVID-19-kidney-AQP1+SLC14A1+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

WNT5B PCSK5 FBLN2 THSD7A ADAMTS9 PTGS2

2.48e-071796561ce8d18f63e8dd2d3db41fbeca4601bd3b305fba
ToppCelldroplet-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBLN2 ZNF585A THSD7A GATA2 GATA6 ZFP28

2.65e-071816562c44c41b4e8a75ebdbaeb0c6cc5a03f17c44758c
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPHB3 PCSK5 VIPR1 FBLN2 THSD7A SPOCK2

2.82e-07183656351d575339038bd4a66f408da518c567444208e8
ToppCellP28-Endothelial-large_vessel_endothelial_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PCSK5 FBLN2 THSD7A GATA6 CTSH PTGS2

3.31e-07188656263169029293e005bcffd87db20221fdd2d3917e
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

WNT5B FBLN2 ADAMTS3 GATA6 EPHA3 PROS1

3.52e-071906560fea33f2dc1efa23aaa2da1c318482a52a313ff1
ToppCellP03-Endothelial-large_vessel_endothelial_cell|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

EPHB4 PCSK5 FBLN2 THSD7A GATA2 GATA6

3.63e-07191656b680e0c35f1004be36f9f0680ae3c62952e2b607
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

EPHB4 PCSK5 FBLN2 THSD7A GATA2 GATA6

3.63e-07191656b270c3dd5952f56b9bdceabe13e298fe6757563b
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

EPHB4 PCSK5 FBLN2 THSD7A GATA2 GATA6

3.63e-0719165627f23c2254b610abac1a88d0fecff305addde9da
ToppCellP07-Endothelial-large_vessel_endothelial_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

EPHB4 PCSK5 FBLN2 THSD7A GATA6 CTSH

3.63e-07191656d162917816dd2e4767c97447c1cddae9397713ab
ToppCellLPS-antiTNF-Endothelial-Endothelial-Artery|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCSK5 FBLN2 THSD7A GATA6 TDRD10 SPOCK2

3.63e-071916564b3d5157344dbfbf4fab518611cd9fa37fac7bd9
ToppCellP15-Endothelial-large_vessel_endothelial_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PCSK5 FBLN2 THSD7A GATA6 CTSH PTGS2

3.86e-071936565f9a7cd5f8eb9ac294cdb50518fedf872f3f78f5
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 WNT5B FBLN2 THSD7A DPF3 TDRD10

4.10e-07195656d35102f95bb1e419d2df05ff0a01b6c5c923acef
ToppCelldroplet-Heart-nan-18m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB4 THSD4 IGF2R GATA2 GATA6 CTSH

4.22e-07196656e386526332138e636aef2542c11316347a45689c
ToppCellBronchial-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

THSD4 FBLN2 THSD7A ADAMTS9 GATA2 EPHA3

4.62e-071996566a2943a23fdd2ec814662db7c21a0d6804a6cbbc
ToppCellLPS_IL1RA-Endothelial-Endothelial-Artery|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

PCSK5 VLDLR FBLN2 THSD7A GATA2 SPOCK2

4.75e-07200656ac9ead34afa14067171833f5c277eaf06db7b02e
ToppCellLPS_only-Endothelial-Endothelial-Artery|LPS_only / Treatment groups by lineage, cell group, cell type

PCSK5 VLDLR FBLN2 THSD7A GATA2 SPOCK2

4.75e-07200656b17eb1587ca86c3d40515128a00a8d8fd787fccf
ToppCellAT1-AT2_cells-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

THSD4 VLDLR ADAMTS9 SPOCK2 PTGS2

1.93e-0614065545d52a086ced8d58e01ac51ac4a90338e8649b16
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Fam159b|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

WNT5B FBLN2 FBN2 ADAMTS3 DPF3

2.54e-061486559205b26e0d042b342cc643cda0f4f3f8bb392d00
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Crispld2_Kcne4|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

WNT5B FBLN2 THSD7A DPF3 EPHA3

3.28e-06156655896e2d958be0a5c62fb6eebad2dfb7e1ce69f3ad
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_artery-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PCSK5 FBLN2 THSD7A GATA2 TDRD10

3.95e-0616265525bb1b9709f960fdf90faff56e874f52a8f5d17e
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 WNT5B FBLN2 DPF3 TDRD10

4.45e-061666558e2faca6a2e76a625de04d6098aa6f98911945c6
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 WNT5B FBLN2 TDRD10 EPHA3

4.45e-061666558e5f2afbeffae5e77fcb29e8fe9f5aa49779b619
ToppCellE15.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PCSK5 FBLN2 THSD7A GATA2 F10

5.44e-06173655b0ff9808e38cb64a734ced498cd0546728746cd5
ToppCellAT1-AT2_cells-Donor_06|World / lung cells shred on cell class, cell subclass, sample id

THSD4 THSD7A ADAMTS9 SPOCK2 PTGS2

5.75e-06175655bdd85ba280648a0283c1984662a34c7b840f64dd
ToppCell3'_v3-lymph-node_spleen-Mast-Mast_cell_lympho|lymph-node_spleen / Manually curated celltypes from each tissue

THSD7A TTC21A GATA2 LRP1 LSS

6.08e-0617765553040dbeb18574a48e352e4bce252c7c3018762c
ToppCellCOVID-19-Heart-EC_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

PCSK5 FBLN2 THSD7A ADAMTS9 GATA2

6.42e-061796552a53d94f6c30bf887dfe88f1693ea057218c852d
ToppCellfacs-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCSK5 FBLN2 THSD7A GATA6 SPOCK2

6.59e-0618065567c5068b660cd5e727a665cefe3bd5f8ae887221
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 FBLN2 THSD7A GATA2 GATA6

6.77e-061816554d7793026373cbcf04b15c77f95f1025d07d4c00
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-5_VIP_TOX2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TYR EREG FBN2 THSD7A FBN3

6.77e-0618165535bcdcd2651149692e5b150e887c0f450c81d2d4
ToppCellfacs-Lung-Endomucin_-18m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 FBLN2 THSD7A GATA6 SPOCK2

6.77e-061816554ea02344e1996f264dd5e14f3b19c8782ce41699
ToppCellfacs-Lung-18m-Endothelial-arterial_endothelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCSK5 FBLN2 THSD7A GATA6 SPOCK2

6.96e-06182655ebc812ed3f25839ea25f76b952c463d79a8325b1
ToppCellfacs-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCSK5 FBLN2 THSD7A GATA6 SPOCK2

6.96e-0618265547ff6b4002a4167412c79210651316d1342503f9
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 FBLN2 THSD7A GATA2 GATA6

7.14e-061836553427f3cbe6ea81709750e7dd3ff378f03ae65eab
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

EPHB4 FBLN2 THSD7A GATA6 CTSH

7.14e-06183655fc9a7ba148c22d0c8a46f6bc56c772929ac496f7
ToppCellP28-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PCSK5 FBLN2 THSD7A GATA6 CTSH

7.33e-061846558ed22b1af04a711203293e7a8b3df6fb9222fad5
ToppCelldroplet-Lung-nan-3m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB4 PCSK5 FBLN2 THSD7A GATA6

7.53e-06185655eeb6f55a6f79adf80247baa2c4b0df44553557ad
ToppCelldroplet-Lung-3m-Endothelial-arterial_endothelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPHB4 FBLN2 THSD7A GATA2 GATA6

7.73e-06186655b80aaeebc03a318052076d2f02c123f5ddc5e73a
ToppCelldroplet-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPHB4 FBLN2 THSD7A GATA2 GATA6

7.73e-061866558a8ed1502542d4895cba3fd5d534256206578716
ToppCellfacs-Heart-LA-24m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THSD4 IGF2R TTC21A GATA2 CTSH

7.93e-06187655d9943e65eedab73d141eae524e2411653a751705
ToppCellfacs-Heart-LA-24m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THSD4 IGF2R TTC21A GATA2 CTSH

7.93e-061876557b13c3b67d66f3afb410141d5471c9e78a4d8623
ToppCellP03-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PCSK5 FBLN2 THSD7A GATA2 GATA6

7.93e-0618765566ebe1788d51b3e17bec6cdb219f709756b4e530
ToppCellfacs-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCSK5 FBLN2 THSD7A GATA6 CTSH

7.93e-061876557170694a1b86fe8d84d96c880ffe57af09bdc026
ToppCelldroplet-Kidney-nan-18m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 VIPR1 FBLN2 THSD7A PTGS2

7.93e-06187655e93cad16a087d1443cbf4e1690dc1b35d7a84c41
ToppCellfacs-Heart-RA-3m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB4 THSD4 IGF2R GATA2 CTSH

8.14e-061886554ddb11a90bf3baa7237bde304db44dfcc56aed52
ToppCellfacs-Heart-RA-3m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB4 THSD4 IGF2R GATA2 CTSH

8.14e-06188655e47e66906922d5c69b1aafe28face0787d3fc563
ToppCellP07-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PCSK5 FBLN2 THSD7A GATA2 GATA6

8.14e-061886555bc1537e079c7435196c163bff5f639ea392a33a
ToppCellE17.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PCSK5 FBLN2 THSD7A GATA2 GATA6

8.14e-0618865559f276e23c8380bae57d7ecca3a8b83df4bc150b
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 WNT5B PCSK5 FBLN2 TDRD10

8.14e-06188655c2c51c6526defe2600302901159b8abbb58d7595
ToppCelldroplet-Lung-nan-18m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 FBLN2 THSD7A GATA2 GATA6

8.14e-06188655405efea75233ecf70f7d19b630230798d817b7f2
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

EPHB4 PCSK5 FBLN2 THSD7A GATA2

8.35e-06189655d17e8467699c7ca7694a313c26111f085df5204e
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 FBLN2 THSD7A GATA2 GATA6

8.35e-061896559da012fdfa9a8d488cab710a463a1d70e89f990c
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 WNT5B PCSK5 FBLN2 EPHA3

8.35e-061896556463890d8dbee4bc198f91628a5f784970de786a
ToppCelldroplet-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPHB4 FBLN2 THSD7A GATA2 GATA6

8.35e-061896552e43428f1ef9683c6f8c9897d46aa7d34bf9047f
ToppCellLPS-IL1RA-Endothelial-Endothelial-Artery|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCSK5 FBLN2 THSD7A GATA6 SPOCK2

8.57e-06190655aed65d584ca0c25f6a8313c66b421a6618af82ea
ToppCelldroplet-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VIPR1 FBLN2 THSD7A GATA6 ZKSCAN4

8.57e-061906553cf464664d6aa22b212e60b70885953887e92483
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 WNT5B PCSK5 FBLN2 TDRD10

8.79e-06191655b2c86cde341fe350143658c8a8a4a9edbce3f19b
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 FBLN2 THSD7A GATA2 GATA6

8.79e-061916553307dbccadb09c62b0e1c0235ec89bb294d748c3
ToppCellCOPD-Endothelial-VE_Arterial|Endothelial / Disease state, Lineage and Cell class

PCSK5 FBLN2 THSD7A GATA6 PTGS2

8.79e-06191655ef16ad1c1cd2c0c0377957398c98775b62a81754
ToppCelldroplet-Heart-nan-18m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THSD4 IGF2R GATA2 GATA6 CTSH

9.01e-061926550b9b2eaed45456d7d74ce78a64ef4a26ac2458fb
ToppCellfacs-Heart-LA-3m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THSD4 IGF2R TTC21A GATA2 CTSH

9.01e-0619265514a816ef116aa992f86edab411f043cf7d07fe04
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 PCSK5 FBLN2 TDRD10 EPHA3

9.01e-0619265556b021c297a21dff357531f21e2464f85186106d
ToppCellfacs-Heart-LA-3m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THSD4 IGF2R TTC21A GATA2 CTSH

9.01e-06192655847822514d747a21d5eb40e04ba9a023fd32bd65
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 WNT5B FBLN2 THSD7A EPHA3

9.24e-061936552e72309607902dabe3218888b22a77fe941f3570
ToppCellPCW_07-8.5|World / Celltypes from embryonic and fetal-stage human lung

THSD4 FBN2 BCAT1 ZNF518B FBN3

9.48e-061946555759c83308df017f1faae248e9b85388e25254f0
ToppCelldroplet-Bladder-Unstain-18m-Epithelial-bladder_mesenchymal_cell_(Car3+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THSD4 EREG ADAMTS9 LRP1 PTGS2

9.72e-06195655841fde528ecb293e07b5e00e499d1e9f0b0dce14
ToppCell3'-Pediatric_IBD-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCSK5 FBLN2 THSD7A ADAMTS9 GATA2

9.72e-06195655b0979c1b5e4576468b8fe4e9027650859e598b34
ToppCell368C|World / Donor, Lineage, Cell class and subclass (all cells)

EREG FBLN2 LRP1 F10 PTGS2

1.02e-05197655f41211923938e5d7bfe6bf24f604ab386f17ef10
ToppCellfacs-Trachea-nan-3m-Mesenchymal-fibroblast|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 VLDLR FBLN2 LRP1 PROS1

1.05e-051986550dc7d59a07428a7b7e8bdc81f0e2417dd4ce3cf2
ToppCell367C-Fibroblasts-Fibroblast-E-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

FBLN2 LRP1 CTSH F10 PROS1

1.07e-051996552aed8f4a225a3762a5e7ce99aacad9b2a37d61f1
ToppCell367C-Fibroblasts-Fibroblast-E|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

FBLN2 LRP1 CTSH F10 PROS1

1.07e-05199655c40ca26345753a2197bd9389d7323f7491c1e11d
ToppCellLung_Parenchyma-Control-Myeloid-Macrophage-Macrophages-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

EPHB4 VIPR1 THSD7A ADAMTS9 GATA2

1.10e-0520065598f6a86fbbe5305c71dae91e7278de9813827935
ToppCellParenchyma_COVID-19-Endothelial-TX|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

EPHB4 VIPR1 THSD7A ADAMTS9 GATA2

1.10e-05200655abcbd5a156aa4fd51d284441388975c81c0b88ae
ToppCellBronchial-10x5prime-Endothelial-Endothelia_vascular-VE_pulmonary_arterial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

VIPR1 FBLN2 THSD7A GATA2 GATA6

1.10e-052006557547d6339f9380d031cfd2cce21ac9a12491e085
ToppCell5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Transitional_Stromal_3_(C3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBLN2 LRP1 BCAT1 F10 PROS1

1.10e-052006556f7f015b5fa1f52374f2c7d9ba339012395eda5f
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal-Interneuron|GW09 / Sample Type, Dataset, Time_group, and Cell type.

PCSK5 GLIPR1L2 SPOCK2 EPHA3 PROS1

1.10e-05200655a6500d0d2e8bcac92381ab771dbdee66b0e1d48e
ToppCellLung_Parenchyma-Control-Endothelial|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

EPHB4 VIPR1 THSD7A ADAMTS9 GATA2

1.10e-0520065541ac6adbf61763aa8a81a0ed586c4a5542a42cc5
ToppCellLPS_IL1RA-Endothelial-Endothelial-Vein|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

EPHB4 FBLN2 ADAMTS9 GATA2 SPOCK2

1.10e-05200655b3f93b71589251197cde96b7bc6d065c106f61cd
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Artery|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

PCSK5 FBLN2 THSD7A GATA2 SPOCK2

1.10e-0520065577ae679c35d3b9e2b620f34129f3a8d47e922c65
ToppCellLung_Parenchyma-Severe-Endothelial|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

EPHB4 VIPR1 THSD7A ADAMTS9 GATA2

1.10e-05200655d9d0ffa18e5b4647966e19ad9830cbba6120677e
ToppCellControl_saline-Endothelial-Endothelial-Artery|Control_saline / Treatment groups by lineage, cell group, cell type

PCSK5 FBLN2 THSD7A GATA2 SPOCK2

1.10e-0520065565b71f1e8da5c3750fcd0a2e66d9ef3125a3f78a
ToppCellmild-HLA-DR-_S100A+_Monocyte|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

DPYD EREG LRP1 CTSH PTGS2

1.10e-052006556dd89835a9f7bebb4849cff8eecb82caf6e1acbf
ToppCellParenchyma_Control_(B.)-Endothelial-TX-Macrophages|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

EPHB4 VIPR1 THSD7A ADAMTS9 GATA2

1.10e-05200655d7b89a721988660d8010c804916f5d0ef2520ee2
ToppCell5'-Adult-SmallIntestine-Mesenchymal-fibroblastic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBLN2 LRP1 BCAT1 F10 PROS1

1.10e-052006553a164e3971bcd62b148b813171c103adb81f972e
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

EPHB4 VIPR1 THSD7A ADAMTS9 GATA2

1.10e-05200655e9d5ba140cabae11c437012d519b85f5412dcc94
ToppCellLung_Parenchyma-Control-Myeloid-Macrophage-Macrophages|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

EPHB4 VIPR1 THSD7A ADAMTS9 GATA2

1.10e-052006551ed1c673184f0c6aae04f90edbb1383b1c1f64d9
ToppCellLung_Parenchyma-Control-Endothelial-Endothelial|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

EPHB4 VIPR1 THSD7A ADAMTS9 GATA2

1.10e-052006555109b417c066ecca0252008206b4f4b7a14c8702
ToppCellLung_Parenchyma-Control-Myeloid-Macrophage|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

EPHB4 VIPR1 THSD7A ADAMTS9 GATA2

1.10e-052006552a1ba87ca4adf351ef8fa2b3154b86a5407b8f2f
ToppCellParenchyma_Control_(B.)-Endothelial-TX|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

EPHB4 VIPR1 THSD7A ADAMTS9 GATA2

1.10e-052006559e5627e11288713aa9b622aae40e849dd6eacd29
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Artery|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

PCSK5 FBLN2 THSD7A GATA2 SPOCK2

1.10e-05200655b1ff8d61b567f85006d6d20093f9c803b6d34674
ToppCellHippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Pvrl3|Hippocampus / BrainAtlas - Mouse McCarroll V32

THSD4 ADAMTS9 DPF3 PTGS2

3.59e-051276549bc55cb9f4bddb274930784d12a83b9dceb35cb7
ToppCellLPS-IL1RA+antiTNF-Endothelial-Epi-like-Gen_Cap|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

VLDLR MIER3 LRP1 ZKSCAN4

5.54e-05142654d52da766e031f7409eb5a7a9fa88f48e14a79d8b
ToppCellLPS-IL1RA+antiTNF-Endothelial-Epi-like|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

VLDLR MIER3 LRP1 ZKSCAN4

5.54e-05142654a05b320cf182b2aaf18df7c40045dc65b659bf20
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Rspo4_Rxfp1_Chat|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

WNT5B FBLN2 EPPIN DPF3

6.01e-0514565478f5f4b96420c7f391e4d32a9ed151ed95fad90b
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Myl1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

WNT5B FBLN2 DPF3 EPHA3

6.01e-05145654590ba937c741ae67460f303eca88b1cd3ac87f64
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 WNT5B PCSK5 EPHA3

7.60e-05154654e51a5114f0ec38f997f5b8bbf3a7770f98595474
ToppCellfacs-Marrow-B-cells-24m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 CTSH F10 PROS1

8.19e-051576540966e347f8d32b13f8a3b3afba3f64637c69cdf9
ToppCellfacs-Marrow-B-cells-24m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 CTSH F10 PROS1

8.19e-051576546ebfedd91d62c6d4aa8f046657a899a279f82ba2
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WNT5B VIPR1 CASP2 ZNF407

8.19e-05157654a426c54fd1545093d41426e9620862f71bd06f6b
ToppCellNS-critical-d_16-33-Myeloid-Mast_cell|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

FBLN2 THSD7A ADAMTS3 GATA2

8.81e-05160654c61869d9dbba250270e59366e15af204e5b4395d
ComputationalMetal / Ca ion binding.

FBLN2 FBN2 LRP1 SPOCK2 F10

1.41e-04133415MODULE_324
ComputationalGenes in the cancer module 121.

EPHB4 VIPR1 LRP1 BCAT1

5.28e-0499414MODULE_121
ComputationalGenes in the cancer module 557.

VIPR1 PTGS2

7.64e-0411412MODULE_557
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

PCSK5 FBLN2 THSD7A

8.91e-0450413GAVISH_3CA_METAPROGRAM_ENDOTHELIAL_NOTCH_SIGNALING
Drughexylresorcinol

TYR PCSK5 ACRV1

3.60e-0611653CID000003610
DiseaseColorectal Carcinoma

DPYD BMPR1A FBLN2 FBN2 LRP1 ZNF217 CTSH PTGS2 EPHA3 PROS1

2.23e-067026310C0009402
Diseaseconnective tissue disease (implicated_via_orthology)

FBN2 FBN3

1.34e-053632DOID:65 (implicated_via_orthology)
Diseaselevel of Sphingomyelin (d40:1) in blood serum

EREG ADAMTS3 RABEP1

4.40e-0532633OBA_2045182
DiseaseSchizophrenia

TYR VLDLR DPYD ADAMTS3 LMX1B LRP1 ZKSCAN4 R3HDML PTGS2

1.03e-04883639C0036341
DiseaseThrombus

F10 PTGS2 PROS1

1.32e-0446633C0087086
DiseaseThrombosis

F10 PTGS2 PROS1

1.59e-0449633C0040053
Diseaseaortic measurement

THSD4 RPL10L GATA2 LRP1 SRL

2.01e-04251635EFO_0020865
DiseaseBarrett's esophagus (is_marker_for)

GATA6 PTGS2

2.44e-0411632DOID:9206 (is_marker_for)
Diseasevital capacity

EPHB3 PCSK5 USP34 SENP1 ADAMTS3 LMX1B ZNF184 SENP2 FBN3 EPHA3

2.71e-0412366310EFO_0004312
Diseasegastric ulcer (implicated_via_orthology)

MUC6 PTGS2

4.02e-0414632DOID:10808 (implicated_via_orthology)
Diseasesevere aplastic anemia

DPYD FBN2

4.63e-0415632EFO_0006927
DiseaseLung diseases

PCSK5 IGF2R PTGS2

6.30e-0478633C0024115
Diseaselevel of Sphingomyelin (d34:1) in blood serum

EREG ADAMTS3

6.71e-0418632OBA_2045175
Diseaseintraocular pressure measurement

TYR PCSK5 FBN2 THSD7A LMX1B DPF3

7.57e-04509636EFO_0004695
DiseaseCongenital diaphragmatic hernia

IGF2R GATA6

9.18e-0421632C0235833
Disease3-hydroxy-1-methylpropylmercapturic acid measurement

USP34 DPYD ADAMTS3 DPF3 PROS1

9.36e-04352635EFO_0007015
Diseasecomplement factor D measurement

EPHB3 THSD7A ZNF518B

1.05e-0393633EFO_0020283
Diseasepancreatic cancer (is_marker_for)

DPYD MUC6 PTGS2

1.33e-03101633DOID:1793 (is_marker_for)
DiseaseAntiglaucoma preparations and miotics use measurement

THSD7A LMX1B

1.41e-0326632EFO_0009944
Diseasecortical surface area measurement, neuroimaging measurement

THSD4 ADAMTS3 ADAMTS9 EPHA3

1.42e-03227634EFO_0004346, EFO_0010736
Diseasecorneal topography

FBLN2 ADAMTS3 LMX1B

1.66e-03109633EFO_0004345
Diseaselevel of Sphingomyelin (d42:2) in blood serum

EREG ADAMTS3

1.76e-0329632OBA_2045183
Diseasepancreatic cancer (is_implicated_in)

DPYD PTGS2 EPHA3

1.79e-03112633DOID:1793 (is_implicated_in)
Diseaselevel of Sphingomyelin (d38:1) in blood serum

EREG ADAMTS3

1.88e-0330632OBA_2045180
Diseaseupper aerodigestive tract neoplasm

THSD4 FBLN2 ZNF184 ZKSCAN4

1.91e-03246634EFO_0004284
Diseasespontaneous coronary artery dissection

THSD4 LRP1

2.00e-0331632EFO_0010820

Protein segments in the cluster

PeptideGeneStartEntry
GNKVKRTSCMYGANC

APLF

371

Q8IW19
CKMGGNYGSSLFAQC

BCAT1

221

P54687
CGKCYMTCNDSGYQA

DPYD

956

Q12882
NTKGSFVCHCQLGYM

FBN3

1256

Q75N90
GSYMCLCHRGFQASA

FBN3

1826

Q75N90
YTCAYMNDQGKCLRG

ACRV1

191

P26436
FMYNSFGCACQATVG

RAB41

51

Q5JT25
GNKLGRRCDMCSNYE

RABEP1

526

Q15276
RKYMGQMCGLCGNFD

MUC6

166

Q6W4X9
KAGFYLAFQDQGACM

EPHB4

171

P54760
KKMYNFENGSCSGDC

GLIPR1L2

141

Q4G1C9
YCDFCLGGSNMNKKS

DPF3

261

Q92784
YCENFGTCQMAADGS

LRP1

4311

Q07954
GSFYCQARQRCMDGF

FBLN2

786

P98095
GDQCMSCKYGYFLNE

PCSK5

701

Q92824
FACMGQTYRDGTACA

LSS

596

P48449
FDNQGYFNSCTMKSC

DCAF5

271

Q96JK2
IDYGKMASQCSCGEA

KDM4D

301

Q6B0I6
CQNRGVCMSVGFDQY

PTGS2

26

P35354
KAGFYLAFQDQGACM

EPHB3

186

P54753
ERYCCNGKASQEGMT

MIER3

266

Q7Z3K6
CNACGLYHKMNGQNR

GATA2

316

P23769
CNACGLYSKMNGLSR

GATA6

411

Q92908
QCRFDFGVGYKMCTA

ADAMTS3

481

O15072
SCGRGHKQRNVYCMA

ADAMTS9

1456

Q9P2N4
FNCSEQMDYKSCGNI

DNAH17

1871

Q9UFH2
LASGCMKYEGSDFQC

BMPR1A

96

P36894
KCSCNAGYEERGFMC

EPHA3

256

P29320
ERGKNMCGLAACASY

CTSH

316

P09668
TKCSSDMNGYCLHGQ

EREG

66

O14944
CNMGYKQDANGDCID

FBN2

521

P35556
NMFCAGYDTKQEDAC

F10

401

P00742
CGYACLKGTAAMRNT

CASP2

366

P42575
SYQGSCNSNMCFKGL

R3HDML

231

Q9H3Y0
DKKDNTCSMFVYGGC

EPPIN

96

O95925
PGCNRYASACQMKYE

IGF2R

821

P11717
CANKYMVKSCGRDGF

RPL10L

71

Q96L21
QQLNGSDCGMFTCKY

SENP2

541

Q9HC62
IKECGQGYRYQAMAC

THSD7A

991

Q9UPZ6
QNGCKCFAFVDLGSM

TDRD10

66

Q5VZ19
QQMNGSDCGMFACKY

SENP1

596

Q9P0U3
CNEDGYMSCKDGKAS

PROS1

126

P07225
DGCDNCDAYLQMKGN

SUPT4H1

31

P63272
YKCMECGKAFGDNSS

ZFP28

701

Q8NHY6
GSVGCKAAMVFFQYC

VIPR1

211

P32241
YKCNECGKMFGQNST

ZNF578

371

Q96N58
LSQQCSYMGGCFLEK

SRL

416

Q86TD4
DGNPYMCEECGKAFN

ZNF607

641

Q96SK3
CSGNFMGFNCGNCKF

TYR

91

P14679
LMCCGRGYNQFKSVQ

WNT5B

316

Q9H1J7
MCQIYLAQGNFGMCF

TTC21A

541

Q8NDW8
YMCNKCGKAFTNRSN

ZNF585A

466

Q6P3V2
PYQCNMCGKAFRRNS

ZKSCAN4

431

Q969J2
RPYMCNECGKAFSQN

ZNF16

291

P17020
KDSFTYGCNMCGRRF

ZNF217

151

O75362
GNVCKYCGKMCRSSN

ZNF407

1536

Q9C0G0
AYDGCSNSELCGMDQ

USP34

1086

Q70CQ2
GNRKCELNCQAMGYR

THSD4

341

Q6ZMP0
YACGDCGKAFSQRMN

ZNF71

186

Q9NQZ8
PYACGDCGKAFSQNM

ZNF71

241

Q9NQZ8
TGVYLCMECGRFFNK

ZNF605

166

Q86T29
GYYRKMQCDQSSGDC

SPOCK2

341

Q92563
CNECGKAFSQRGHFM

ZNF184

336

Q99676
CDGCGKRFYMNSQGH

ZNF284

401

Q2VY69
KGTGKDGMYVCFQCS

ZNF518B

76

Q9C0D4
GYKCECSRGYQMDLA

VLDLR

416

P98155
DYQQLFAAKCSGCME

LMX1B

106

O60663