Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	sialic acid binding	SIGLEC14 SIGLEC5 SIGLEC8 CD33 SIGLEC6	1.46e-09	25	41	5	GO:0033691
GeneOntologyMolecularFunction	monosaccharide binding	SIGLEC14 SIGLEC5 PLOD1 SIGLEC8 SIGLEC6	1.43e-06	95	41	5	GO:0048029
GeneOntologyMolecularFunction	hormone activity	LHB CGB7 TRH INSL6 CGB3	8.08e-06	135	41	5	GO:0005179
GeneOntologyMolecularFunction	carboxylic acid binding	SIGLEC14 SIGLEC5 PLOD1 SIGLEC8 CD33 SIGLEC6	8.74e-06	239	41	6	GO:0031406
GeneOntologyMolecularFunction	organic acid binding	SIGLEC14 SIGLEC5 PLOD1 SIGLEC8 CD33 SIGLEC6	1.24e-05	254	41	6	GO:0043177
GeneOntologyMolecularFunction	signaling receptor regulator activity	LHB FGF3 CGB7 LYPD6 BMP8B TRH INSL6 CGB3	3.05e-05	616	41	8	GO:0030545
GeneOntologyMolecularFunction	carbohydrate binding	SIGLEC14 SIGLEC5 PLOD1 SIGLEC8 CD33 SIGLEC6	3.80e-05	310	41	6	GO:0030246
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	SCARF1 IFNGR2 UTS2R FCRL3 GRM2 PLXNB2 TAS1R3 SIGLEC8 ALK PLXNA1 S1PR4	6.32e-05	1353	41	11	GO:0004888
GeneOntologyMolecularFunction	receptor ligand activity	LHB FGF3 CGB7 BMP8B TRH INSL6 CGB3	1.12e-04	547	41	7	GO:0048018
GeneOntologyMolecularFunction	signaling receptor activator activity	LHB FGF3 CGB7 BMP8B TRH INSL6 CGB3	1.21e-04	554	41	7	GO:0030546
GeneOntologyMolecularFunction	molecular function activator activity	LHB FGF3 CGB7 BMP8B LRCOL1 TRH INSL6 ALK CD33 CGB3	1.50e-04	1233	41	10	GO:0140677
GeneOntologyMolecularFunction	semaphorin receptor activity	PLXNB2 PLXNA1	2.68e-04	12	41	2	GO:0017154
GeneOntologyBiologicalProcess	luteinizing hormone signaling pathway involved in ovarian follicle development	LHB CGB7	3.84e-05	5	41	2	GO:0035471
GeneOntologyBiologicalProcess	luteinizing hormone signaling pathway	LHB CGB7	8.04e-05	7	41	2	GO:0042700
GeneOntologyCellularComponent	pituitary gonadotropin complex	LHB CGB7 CGB3	4.19e-07	8	42	3	GO:0061696
GeneOntologyCellularComponent	collagen-containing extracellular matrix	MST1 C1QB PODNL1 CTSF CPN2 PLXNB2 PLOD1	8.09e-05	530	42	7	GO:0062023
GeneOntologyCellularComponent	extracellular matrix	MST1 C1QB PODNL1 CTSF CPN2 PLXNB2 PLOD1	3.01e-04	656	42	7	GO:0031012
GeneOntologyCellularComponent	semaphorin receptor complex	PLXNB2 PLXNA1	3.03e-04	13	42	2	GO:0002116
GeneOntologyCellularComponent	external encapsulating structure	MST1 C1QB PODNL1 CTSF CPN2 PLXNB2 PLOD1	3.07e-04	658	42	7	GO:0030312
GeneOntologyCellularComponent	9+2 non-motile cilium	STRC STRCP1	3.53e-04	14	42	2	GO:0097732
GeneOntologyCellularComponent	kinocilium	STRC STRCP1	3.53e-04	14	42	2	GO:0060091
GeneOntologyCellularComponent	tertiary granule membrane	SIGLEC14 SIGLEC5 CD33	4.25e-04	73	42	3	GO:0070821
GeneOntologyCellularComponent	stereocilium tip	STRC STRCP1	8.87e-04	22	42	2	GO:0032426
GeneOntologyCellularComponent	tertiary granule	SIGLEC14 SIGLEC5 CD33	4.35e-03	164	42	3	GO:0070820
GeneOntologyCellularComponent	cell surface	SCART1 FCRL3 STRC PLXNB2 SIGLEC8 CD33 STRCP1	6.20e-03	1111	42	7	GO:0009986
GeneOntologyCellularComponent	ficolin-1-rich granule membrane	SIGLEC14 SIGLEC5	6.69e-03	61	42	2	GO:0101003
GeneOntologyCellularComponent	side of membrane	SCART1 LYPD6 FCRL3 ART4 SIGLEC8 CD33	7.65e-03	875	42	6	GO:0098552
GeneOntologyCellularComponent	stereocilium	STRC STRCP1	8.49e-03	69	42	2	GO:0032420
GeneOntologyCellularComponent	cluster of actin-based cell projections	SCART1 STRC STRCP1	1.01e-02	223	42	3	GO:0098862
MousePheno	abnormal eosinophil differentiation	SIGLEC14 SIGLEC5 SIGLEC6	6.26e-08	4	36	3	MP:0002443
MousePheno	abnormal myelopoiesis	SIGLEC14 SIGLEC5 LCN2 SIGLEC6 S1PR4	1.25e-05	119	36	5	MP:0001601
MousePheno	abnormal eosinophil physiology	SIGLEC14 SIGLEC5 SIGLEC6	8.12e-05	33	36	3	MP:0002465
MousePheno	small vulva	LHB CGB7	9.61e-05	6	36	2	MP:0003527
MousePheno	abnormal leukopoiesis	IFNGR2 SIGLEC14 SIGLEC5 LCN2 PTCRA MZB1 SIGLEC6 S1PR4	1.07e-04	594	36	8	MP:0005460
MousePheno	small bulbourethral gland	LHB CGB7	1.34e-04	7	36	2	MP:0013737
MousePheno	abnormal granulocyte differentiation	SIGLEC14 SIGLEC5 SIGLEC6	1.35e-04	39	36	3	MP:0008111
MousePheno	abnormal immune system development	IFNGR2 SIGLEC14 SIGLEC5 LCN2 PTCRA MZB1 SIGLEC6 S1PR4	1.37e-04	616	36	8	MP:0020981
MousePheno	small external male genitalia	LHB CGB7	1.79e-04	8	36	2	MP:0009202
MousePheno	abnormal bulbourethral gland morphology	LHB CGB7	4.19e-04	12	36	2	MP:0001169
MousePheno	abnormal granulocyte physiology	SIGLEC14 SIGLEC5 LCN2 SIGLEC8 SIGLEC6	4.29e-04	251	36	5	MP:0002462
MousePheno	decreased circulating testosterone level	LHB CGB7 ALK	4.85e-04	60	36	3	MP:0002780
Domain	Gonadotropin_bsu_CS	LHB CGB7 CGB3	1.81e-07	6	40	3	IPR018245
Domain	Gonadotropin_bsu	LHB CGB7 CGB3	3.17e-07	7	40	3	IPR001545
Domain	GLYCO_HORMONE_BETA_2	LHB CGB7 CGB3	3.17e-07	7	40	3	PS00689
Domain	GHB	LHB CGB7 CGB3	3.17e-07	7	40	3	SM00068
Domain	GLYCO_HORMONE_BETA_1	LHB CGB7 CGB3	3.17e-07	7	40	3	PS00261
Domain	-	IFNGR2 SIGLEC14 SIGLEC5 FCRL3 PTCRA PLXNB2 SIGLEC8 PLXNA1 CD33 SIGLEC6	9.60e-07	663	40	10	2.60.40.10
Domain	Ig-like_fold	IFNGR2 SIGLEC14 SIGLEC5 FCRL3 PTCRA PLXNB2 SIGLEC8 PLXNA1 CD33 SIGLEC6	1.69e-06	706	40	10	IPR013783
Domain	ig	SIGLEC14 SIGLEC5 FCRL3 SIGLEC8 CD33 SIGLEC6	2.95e-06	190	40	6	PF00047
Domain	Immunoglobulin	SIGLEC14 SIGLEC5 FCRL3 SIGLEC8 CD33 SIGLEC6	2.95e-06	190	40	6	IPR013151
Domain	Glyco_hormone_CN	LHB CGB7 CGB3	4.07e-06	15	40	3	IPR006208
Domain	Cys_knot	LHB CGB7 CGB3	4.07e-06	15	40	3	PF00007
Domain	-	LHB CGB7 BMP8B CGB3	1.25e-05	67	40	4	2.10.90.10
Domain	Cystine-knot_cytokine	LHB CGB7 BMP8B CGB3	1.25e-05	67	40	4	IPR029034
Domain	V-set	SIGLEC14 SIGLEC5 SIGLEC8 CD33 SIGLEC6	4.37e-05	184	40	5	PF07686
Domain	Ig_V-set	SIGLEC14 SIGLEC5 SIGLEC8 CD33 SIGLEC6	6.35e-05	199	40	5	IPR013106
Domain	Ig-like_dom	SIGLEC14 SIGLEC5 FCRL3 PTCRA SIGLEC8 CD33 SIGLEC6	8.50e-05	503	40	7	IPR007110
Domain	IGc2	SIGLEC14 SIGLEC5 FCRL3 SIGLEC8 SIGLEC6	1.39e-04	235	40	5	SM00408
Domain	Ig_sub2	SIGLEC14 SIGLEC5 FCRL3 SIGLEC8 SIGLEC6	1.39e-04	235	40	5	IPR003598
Domain	Plexin_cytopl	PLXNB2 PLXNA1	1.59e-04	9	40	2	PF08337
Domain	Plexin_cytoplasmic_RasGAP_dom	PLXNB2 PLXNA1	1.59e-04	9	40	2	IPR013548
Domain	Plexin	PLXNB2 PLXNA1	1.59e-04	9	40	2	IPR031148
Domain	IG	SIGLEC14 SIGLEC5 FCRL3 SIGLEC8 CD33 SIGLEC6	2.54e-04	421	40	6	SM00409
Domain	Ig_sub	SIGLEC14 SIGLEC5 FCRL3 SIGLEC8 CD33 SIGLEC6	2.54e-04	421	40	6	IPR003599
Domain	Ig/MHC_CS	SIGLEC14 SIGLEC5 SIGLEC6	2.59e-04	58	40	3	IPR003006
Domain	IG_MHC	SIGLEC14 SIGLEC5 SIGLEC6	2.86e-04	60	40	3	PS00290
Domain	NCD3G	GRM2 TAS1R3	3.44e-04	13	40	2	PF07562
Domain	GPCR_3_9-Cys_dom	GRM2 TAS1R3	3.44e-04	13	40	2	IPR011500
Domain	GPCR_3_CS	GRM2 TAS1R3	4.00e-04	14	40	2	IPR017979
Domain	IG_LIKE	SIGLEC14 SIGLEC5 FCRL3 SIGLEC8 CD33 SIGLEC6	5.75e-04	491	40	6	PS50835
Domain	GPCR_3	GRM2 TAS1R3	9.15e-04	21	40	2	IPR000337
Domain	G_PROTEIN_RECEP_F3_4	GRM2 TAS1R3	1.01e-03	22	40	2	PS50259
Domain	7tm_3	GRM2 TAS1R3	1.01e-03	22	40	2	PF00003
Domain	GPCR_3_C	GRM2 TAS1R3	1.01e-03	22	40	2	IPR017978
Domain	G_PROTEIN_RECEP_F3_2	GRM2 TAS1R3	1.01e-03	22	40	2	PS00980
Domain	G_PROTEIN_RECEP_F3_3	GRM2 TAS1R3	1.01e-03	22	40	2	PS00981
Domain	G_PROTEIN_RECEP_F3_1	GRM2 TAS1R3	1.01e-03	22	40	2	PS00979
Domain	Ig_E-set	CPAMD8 PLXNB2 PLXNA1	1.43e-03	104	40	3	IPR014756
Domain	IPT	PLXNB2 PLXNA1	1.52e-03	27	40	2	SM00429
Domain	TIG	PLXNB2 PLXNA1	2.00e-03	31	40	2	PF01833
Domain	SEMA	PLXNB2 PLXNA1	2.00e-03	31	40	2	PS51004
Domain	Sema	PLXNB2 PLXNA1	2.00e-03	31	40	2	SM00630
Domain	Semap_dom	PLXNB2 PLXNA1	2.00e-03	31	40	2	IPR001627
Domain	Sema	PLXNB2 PLXNA1	2.00e-03	31	40	2	PF01403
Domain	Plexin_repeat	PLXNB2 PLXNA1	2.13e-03	32	40	2	IPR002165
Domain	PSI	PLXNB2 PLXNA1	2.13e-03	32	40	2	PF01437
Domain	IPT	PLXNB2 PLXNA1	2.13e-03	32	40	2	IPR002909
Domain	ANF_receptor	GRM2 TAS1R3	2.84e-03	37	40	2	PF01094
Domain	ANF_lig-bd_rcpt	GRM2 TAS1R3	2.84e-03	37	40	2	IPR001828
Domain	Peripla_BP_I	GRM2 TAS1R3	3.15e-03	39	40	2	IPR028082
Domain	PSI	PLXNB2 PLXNA1	4.00e-03	44	40	2	IPR016201
Domain	PSI	PLXNB2 PLXNA1	4.36e-03	46	40	2	SM00423
Domain	Ig_I-set	SIGLEC14 SIGLEC8 SIGLEC6	7.77e-03	190	40	3	IPR013098
Domain	I-set	SIGLEC14 SIGLEC8 SIGLEC6	7.77e-03	190	40	3	PF07679
Domain	Ig_2	SIGLEC14 FCRL3	1.07e-02	73	40	2	PF13895
Domain	Rho_GTPase_activation_prot	PLXNB2 PLXNA1	1.52e-02	88	40	2	IPR008936
Pathway	REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL	SIGLEC14 SIGLEC5 SIGLEC8 CD33 SIGLEC6	1.66e-05	135	34	5	MM14781
Pathway	REACTOME_GPCR_LIGAND_BINDING	LHB CGB7 UTS2R TRH GRM2 TAS1R3 S1PR4	6.16e-05	430	34	7	MM15160
Pathway	REACTOME_MINERALOCORTICOID_BIOSYNTHESIS	LHB CGB7	3.67e-04	12	34	2	MM14749
Pathway	REACTOME_GLYCOPROTEIN_HORMONES	LHB CGB7	4.33e-04	13	34	2	MM14830
Pathway	REACTOME_REACTIONS_SPECIFIC_TO_THE_COMPLEX_N_GLYCAN_SYNTHESIS_PATHWAY	LHB CGB7	4.33e-04	13	34	2	MM15701
Pathway	REACTOME_PEPTIDE_HORMONE_BIOSYNTHESIS	LHB CGB3	5.05e-04	14	34	2	M756
Pathway	REACTOME_PEPTIDE_HORMONE_BIOSYNTHESIS	LHB CGB7	5.81e-04	15	34	2	MM14832
Pathway	REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS	LHB CGB7	5.81e-04	15	34	2	MM14972
Pathway	REACTOME_ANDROGEN_BIOSYNTHESIS	LHB CGB7	5.81e-04	15	34	2	MM14739
Pathway	REACTOME_GPCR_LIGAND_BINDING	LHB UTS2R TRH GRM2 TAS1R3 S1PR4	7.47e-04	463	34	6	M507
Pathway	REACTOME_SIGNALING_BY_GPCR	LHB CGB7 UTS2R TRH GRM2 TAS1R3 S1PR4	7.48e-04	646	34	7	MM14962
Pathway	REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL	SIGLEC5 SIGLEC8 CD33 SIGLEC6	1.08e-03	190	34	4	M8240
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	LHB CGB7 UTS2R TRH S1PR4	1.13e-03	333	34	5	MM14963
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_THE_AP_2_TFAP2_FAMILY_OF_TRANSCRIPTION_FACTORS	LHB CGB7	1.77e-03	26	34	2	MM15502
Pubmed	Siglec-8 on human eosinophils and mast cells, and Siglec-F on murine eosinophils, are functionally related inhibitory receptors.	SIGLEC14 SIGLEC5 SIGLEC8 SIGLEC6	1.84e-12	4	42	4	19178537
Pubmed	CD24-Siglec axis is an innate immune checkpoint against metaflammation and metabolic disorder.	SIGLEC14 SIGLEC5 SIGLEC8 CD33 SIGLEC6	2.56e-12	13	42	5	35921817
Pubmed	[Functions and molecular evolution of Siglecs, a family of sialic acid receptor proteins].	SIGLEC14 SIGLEC5 SIGLEC8 SIGLEC6	6.41e-11	7	42	4	18453149
Pubmed	The murine inhibitory receptor mSiglec-E is expressed broadly on cells of the innate immune system whereas mSiglec-F is restricted to eosinophils.	SIGLEC14 SIGLEC5 SIGLEC8 SIGLEC6	6.41e-11	7	42	4	15048729
Pubmed	Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs.	SIGLEC5 SIGLEC8 CD33 SIGLEC6	3.84e-10	10	42	4	25320078
Pubmed	Selective Response to Bacterial Infection by Regulating Siglec-E Expression.	SIGLEC14 SIGLEC5 SIGLEC8 SIGLEC6	6.02e-10	11	42	4	32889432
Pubmed	Siglec-F-dependent negative regulation of allergen-induced eosinophilia depends critically on the experimental model.	SIGLEC14 SIGLEC5 SIGLEC6	1.64e-09	3	42	3	24698729
Pubmed	Cloning and characterization of a novel mouse Siglec, mSiglec-F: differential evolution of the mouse and human (CD33) Siglec-3-related gene clusters.	SIGLEC14 SIGLEC5 SIGLEC6	1.64e-09	3	42	3	11579105
Pubmed	Chorionic gonadotropin has a recent origin within primates and an evolutionary history of selection.	LHB CGB7 CGB3	1.64e-09	3	42	3	11861891
Pubmed	Siglec-F is induced by granulocyte-macrophage colony-stimulating factor and enhances interleukin-4-induced expression of arginase-1 in mouse macrophages.	SIGLEC14 SIGLEC5 SIGLEC6	1.64e-09	3	42	3	31520477
Pubmed	Antiallergic effect of anti-Siglec-F through reduction of eosinophilic inflammation in murine allergic rhinitis.	SIGLEC14 SIGLEC5 SIGLEC6	1.64e-09	3	42	3	23710953
Pubmed	Anti-Siglec-F antibody reduces allergen-induced eosinophilic inflammation and airway remodeling.	SIGLEC14 SIGLEC5 SIGLEC6	1.64e-09	3	42	3	19783675
Pubmed	Mast Cell-Specific Expression of Human Siglec-8 in Conditional Knock-in Mice.	SIGLEC14 SIGLEC5 SIGLEC6	1.64e-09	3	42	3	30577572
Pubmed	A novel Siglec-F+ neutrophil subset in the mouse nasal mucosa exhibits an activated phenotype and is increased in an allergic rhinitis model.	SIGLEC14 SIGLEC5 SIGLEC6	1.64e-09	3	42	3	32247614
Pubmed	Frontline Science: Superior mouse eosinophil depletion in vivo targeting transgenic Siglec-8 instead of endogenous Siglec-F: Mechanisms and pitfalls.	SIGLEC14 SIGLEC5 SIGLEC6	1.64e-09	3	42	3	32134149
Pubmed	Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis.	SIGLEC14 SIGLEC5 SIGLEC6	1.64e-09	3	42	3	25497369
Pubmed	Siglec-F is a novel intestinal M cell marker.	SIGLEC14 SIGLEC5 SIGLEC6	1.64e-09	3	42	3	27524237
Pubmed	Distinct endocytic mechanisms of CD22 (Siglec-2) and Siglec-F reflect roles in cell signaling and innate immunity.	SIGLEC14 SIGLEC5 SIGLEC6	6.54e-09	4	42	3	17562860
Pubmed	Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils.	SIGLEC14 SIGLEC5 SIGLEC6	6.54e-09	4	42	3	17272508
Pubmed	Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration.	SIGLEC14 SIGLEC5 SIGLEC6	6.54e-09	4	42	3	33289969
Pubmed	Induction of Siglec-FhiCD101hi eosinophils in the lungs following murine hookworm Nippostrongylus brasiliensis infection.	SIGLEC14 SIGLEC5 SIGLEC6	6.54e-09	4	42	3	37251384
Pubmed	IL-17 mediates protective immunity against nasal infection with Bordetella pertussis by mobilizing neutrophils, especially Siglec-F+ neutrophils.	SIGLEC14 SIGLEC5 SIGLEC6	6.54e-09	4	42	3	33976385
Pubmed	Evolution of different transcriptional start sites in the human luteinizing hormone and chorionic gonadotropin beta-subunit genes.	LHB CGB7 CGB3	1.63e-08	5	42	3	2424697
Pubmed	Characterization of expression of glycan ligands for Siglec-F in normal mouse lungs.	SIGLEC14 SIGLEC5 SIGLEC6	1.63e-08	5	42	3	20395633
Pubmed	Chronic OVA allergen challenged Siglec-F deficient mice have increased mucus, remodeling, and epithelial Siglec-F ligands which are up-regulated by IL-4 and IL-13.	SIGLEC14 SIGLEC5 SIGLEC6	1.63e-08	5	42	3	21040544
Pubmed	Siglec-F-expressing neutrophils are essential for creating a profibrotic microenvironment in renal fibrosis.	SIGLEC14 SIGLEC5 SIGLEC6	1.63e-08	5	42	3	35482420
Pubmed	Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms.	SIGLEC14 SIGLEC5 SIGLEC8 SIGLEC6	1.92e-08	24	42	4	15331780
Pubmed	Galactose 6-O-sulfotransferases are not required for the generation of Siglec-F ligands in leukocytes or lung tissue.	SIGLEC14 SIGLEC5 SIGLEC6	3.27e-08	6	42	3	23880769
Pubmed	Molecular analysis of human Siglec-8 orthologs relevant to mouse eosinophils: identification of mouse orthologs of Siglec-5 (mSiglec-F) and Siglec-10 (mSiglec-G).	SIGLEC14 SIGLEC5 SIGLEC6	3.27e-08	6	42	3	14559209
Pubmed	Sialyltransferase ST3Gal-III regulates Siglec-F ligand formation and eosinophilic lung inflammation in mice.	SIGLEC14 SIGLEC5 SIGLEC6	5.71e-08	7	42	3	23677475
Pubmed	Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone.	LHB CGB7 CGB3	5.71e-08	7	42	3	6690982
Pubmed	Mechanisms of Siglec-F-induced eosinophil apoptosis: a role for caspases but not for SHP-1, Src kinases, NADPH oxidase or reactive oxygen.	SIGLEC14 SIGLEC5 SIGLEC6	5.71e-08	7	42	3	23840825
Pubmed	Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1.	SIGLEC5 SIGLEC8 SIGLEC6	9.13e-08	8	42	3	25187624
Pubmed	Requirement of thyrotropin-releasing hormone for the postnatal functions of pituitary thyrotrophs: ontogeny study of congenital tertiary hypothyroidism in mice.	LHB CGB7 TRH	1.10e-06	17	42	3	10628753
Pubmed	Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization.	SIGLEC14 SIGLEC5 SIGLEC6	1.10e-06	17	42	3	35709757
Pubmed	Loss-of-function mutations in IGSF1 cause an X-linked syndrome of central hypothyroidism and testicular enlargement.	LHB CGB7 TRH	1.32e-06	18	42	3	23143598
Pubmed	Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus.	SIGLEC14 SIGLEC5	1.42e-06	2	42	2	24799499
Pubmed	Eutopic production of human chorionic gonadotropin beta (hCG beta) and luteinizing hormone beta (hLH beta) in the human testis.	LHB CGB3	1.42e-06	2	42	2	7513655
Pubmed	Site-specific N-glycosylation of human chorionic gonadotrophin--structural analysis of glycopeptides by one- and two-dimensional 1H NMR spectroscopy.	CGB7 CGB3	1.42e-06	2	42	2	1820200
Pubmed	Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.	STRC STRCP1	1.42e-06	2	42	2	34910522
Pubmed	Assessment of beta-HCG, beta-LH mRNA and ploidy in individual human blastomeres.	LHB CGB3	1.42e-06	2	42	2	12419040
Pubmed	Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.	STRC STRCP1	1.42e-06	2	42	2	11687802
Pubmed	Tumorigenesis and metastasis of neoplastic Kaposi's sarcoma cell line in immunodeficient mice blocked by a human pregnancy hormone.	CGB7 CGB3	1.42e-06	2	42	2	7723844
Pubmed	Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14.	SIGLEC14 SIGLEC5	1.42e-06	2	42	2	26459514
Pubmed	Molecular cloning of a novel gene similar to myeloid antigen CD33 and its specific expression in placenta.	CD33 SIGLEC6	1.42e-06	2	42	2	9465907
Pubmed	The cDNA for the beta-subunit of human chorionic gonadotropin suggests evolution of a gene by readthrough into the 3'-untranslated region.	CGB7 CGB3	1.42e-06	2	42	2	6774259
Pubmed	Heterodimerization of Chemoreceptors TAS1R3 and mGlu2 in Human Blood Leukocytes.	GRM2 TAS1R3	1.42e-06	2	42	2	37629122
Pubmed	Sox21 deletion in mice causes postnatal growth deficiency without physiological disruption of hypothalamic-pituitary endocrine axes.	LHB CGB7 TRH	1.57e-06	19	42	3	27616671
Pubmed	Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.	STRC STRCP1	4.27e-06	3	42	2	30801007
Pubmed	Abortive expansion of the cumulus and impaired fertility in mice lacking the prostaglandin E receptor subtype EP(2).	CGB7 CGB3	4.27e-06	3	42	2	10468638
Pubmed	Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates.	SIGLEC14 SIGLEC5	4.27e-06	3	42	2	17012248
Pubmed	OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the immunoglobulin superfamily.	SIGLEC5 SIGLEC6	4.27e-06	3	42	2	10428856
Pubmed	Role of disulfide bond formation in the folding of human chorionic gonadotropin beta subunit into an alpha beta dimer assembly-competent form.	CGB7 CGB3	4.27e-06	3	42	2	1688430
Pubmed	Transcription factor 7-like 1 is involved in hypothalamo-pituitary axis development in mice and humans.	LHB CGB7 TRH	4.69e-06	27	42	3	26764381
Pubmed	A suite of new Dre recombinase drivers markedly expands the ability to perform intersectional genetic targeting.	SIGLEC14 SIGLEC5 SIGLEC6	5.85e-06	29	42	3	33567267
Pubmed	Crystal structure of human chorionic gonadotropin.	CGB7 CGB3	8.53e-06	4	42	2	8202136
Pubmed	Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.	STRC STRCP1	8.53e-06	4	42	2	18849963
Pubmed	Evidence for C1q-mediated crosslinking of CD33/LAIR-1 inhibitory immunoreceptors and biological control of CD33/LAIR-1 expression.	C1QB CD33	8.53e-06	4	42	2	28325905
Pubmed	Identification of a promoter region in the CG beta gene cluster.	CGB7 CGB3	8.53e-06	4	42	2	2452822
Pubmed	Histone deacetylase 3 controls lung alveolar macrophage development and homeostasis.	SIGLEC14 SIGLEC5 SIGLEC6	1.24e-05	37	42	3	32732898
Pubmed	Genomic organization of the siglec gene locus on chromosome 19q13.4 and cloning of two new siglec pseudogenes.	SIGLEC5 CD33	1.42e-05	5	42	2	11943481
Pubmed	Luteinizing hormone induction of ovarian tumors: oligogenic differences between mouse strains dictates tumor disposition.	LHB CGB7	1.42e-05	5	42	2	10618427
Pubmed	Androgen-responsive microRNAs in mouse Sertoli cells.	LHB CGB7	1.42e-05	5	42	2	22911753
Pubmed	Cloning of the mouse gonadotropin beta-subunit-encoding genes, II. Structure of the luteinizing hormone beta-subunit-encoding genes.	LHB CGB7	1.42e-05	5	42	2	8543188
Pubmed	Isolation and characterization of the human chorionic gonadotropin beta subunit (CG beta) gene cluster: regulation of transcriptionally active CG beta gene by cyclic AMP.	CGB7 CGB3	1.42e-05	5	42	2	2468994
Pubmed	Microglial CD33-related Siglec-E inhibits neurotoxicity by preventing the phagocytosis-associated oxidative burst.	SIGLEC8 CD33	1.42e-05	5	42	2	24227736
Pubmed	Hypogonadism caused by a single amino acid substitution in the beta subunit of luteinizing hormone.	LHB CGB7	1.42e-05	5	42	2	1727547
Pubmed	Targeted overexpression of luteinizing hormone in transgenic mice leads to infertility, polycystic ovaries, and ovarian tumors.	LHB CGB7	1.42e-05	5	42	2	7877975
Pubmed	Luteinizing hormone beta promoter stimulation by adenylyl cyclase and cooperation with gonadotropin-releasing hormone 1 in transgenic mice and LBetaT2 Cells.	LHB CGB7	1.42e-05	5	42	2	17699734
Pubmed	The pleiotropic effects of excessive luteinizing hormone secretion in transgenic mice.	LHB CGB7	1.42e-05	5	42	2	17710732
Pubmed	Targeted disruption of luteinizing hormone beta-subunit leads to hypogonadism, defects in gonadal steroidogenesis, and infertility.	LHB CGB7	1.42e-05	5	42	2	15569941
Pubmed	Lipocalin 2 from macrophages stimulated by tumor cell-derived sphingosine 1-phosphate promotes lymphangiogenesis and tumor metastasis.	LCN2 S1PR4	1.42e-05	5	42	2	27353364
Pubmed	Sulfation of LH does not affect intracellular trafficking.	LHB CGB7	1.42e-05	5	42	2	19647136
Pubmed	Expression of the beta subunit of chorionic gonadotropin in transgenic mice.	LHB CGB7	1.42e-05	5	42	2	7508931
Pubmed	Elevated luteinizing hormone in prepubertal transgenic mice causes hyperandrogenemia, precocious puberty, and substantial ovarian pathology.	LHB CGB7	1.42e-05	5	42	2	9231809
Pubmed	Targeted overexpression of luteinizing hormone causes ovary-dependent functional adenomas restricted to cells of the Pit-1 lineage.	LHB CGB7	1.42e-05	5	42	2	12960102
Pubmed	Ovulatory surges of human CG prevent hormone-induced granulosa cell tumor formation leading to the identification of tumor-associated changes in the transcriptome.	LHB CGB7	1.42e-05	5	42	2	12040011
Pubmed	An Otx-related homeodomain protein binds an LHbeta promoter element important for activation during gonadotrope maturation.	LHB CGB7	1.42e-05	5	42	2	12040015
Pubmed	An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells.	STRC STRCP1	1.42e-05	5	42	2	24920589
Pubmed	The prognostic impact of SIGLEC5-induced impairment of CD8+ T cell activation in sepsis.	SIGLEC5 SIGLEC8	1.42e-05	5	42	2	37890368
Pubmed	Transgenic mice with chronically elevated luteinizing hormone are infertile due to anovulation, defects in uterine receptivity, and midgestation pregnancy failure.	LHB CGB7	1.42e-05	5	42	2	10342846
Pubmed	Stress levels of glucocorticoids inhibit LHβ-subunit gene expression in gonadotrope cells.	LHB CGB7	1.42e-05	5	42	2	22851703
Pubmed	The role of luteinizing hormone-beta gene polymorphism in the onset and progression of puberty in healthy boys.	LHB CGB7	1.42e-05	5	42	2	8784083
Pubmed	An i-motif-regulated enhancer, eRNA and adjacent lncRNA affect Lhb expression through distinct mechanisms in a sex-specific context.	LHB CGB7	1.42e-05	5	42	2	39158745
Pubmed	A mouse knockout library for secreted and transmembrane proteins.	SIGLEC14 SIGLEC5 LYPD6 SIGLEC8 SIGLEC6 CLDN2	1.82e-05	460	42	6	20562862
Pubmed	Claudin-9 constitutes tight junctions of folliculo-stellate cells in the anterior pituitary gland.	LHB CGB7 CLDN2	1.95e-05	43	42	3	34737342
Pubmed	Effect of Soluble Adenylyl Cyclase (ADCY10) Inhibitors on the LH-Stimulated cAMP Synthesis in Mltc-1 Leydig Cell Line.	LHB CGB7	2.13e-05	6	42	2	33924969
Pubmed	The beta subunit of human chorionic gonadotropin is encoded by multiple genes.	CGB7 CGB3	2.13e-05	6	42	2	6194155
Pubmed	Development of a methodology for and assessment of pulsatile luteinizing hormone secretion in juvenile and adult male mice.	LHB CGB7	2.13e-05	6	42	2	24092638
Pubmed	Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition.	LHB CGB7	2.13e-05	6	42	2	14871891
Pubmed	Identification of the transcriptionally active genes of the chorionic gonadotropin beta gene cluster in vivo.	CGB7 CGB3	2.13e-05	6	42	2	1371113
Pubmed	AMP-activated protein kinase is a key intermediary in GnRH-stimulated LHβ gene transcription.	LHB CGB7	2.13e-05	6	42	2	23518923
Pubmed	Free fatty acids induce Lhb mRNA but suppress Fshb mRNA in pituitary LβT2 gonadotropes and diet-induced obesity reduces FSH levels in male mice and disrupts the proestrous LH/FSH surge in female mice.	LHB CGB7	2.13e-05	6	42	2	23525221
Pubmed	Maximal activity of the luteinizing hormone beta-subunit gene requires beta-catenin.	LHB CGB7	2.13e-05	6	42	2	17244763
Pubmed	The human genome contains seven genes for the beta-subunit of chorionic gonadotropin but only one gene for the beta-subunit of luteinizing hormone.	CGB7 CGB3	2.13e-05	6	42	2	6319099
Pubmed	The role of amino acid neurotransmitters in the regulation of pituitary gonadotropin release in fish.	LHB CGB7	2.13e-05	6	42	2	10949077
Pubmed	Secretoneurin stimulates the production and release of luteinizing hormone in mouse L{beta}T2 gonadotropin cells.	LHB CGB7	2.13e-05	6	42	2	21521715
Pubmed	Dependence of uterine cyclooxygenase2 expression on luteinizing hormone signaling.	LHB CGB7	2.13e-05	6	42	2	15814897
Pubmed	Prolactin regulation of gonadotropin-releasing hormone neurons to suppress luteinizing hormone secretion in mice.	LHB CGB7	2.13e-05	6	42	2	17569755
Pubmed	Functional analysis of LHbeta knockout mice.	LHB CGB7	2.13e-05	6	42	2	17350160
Interaction	CXCL9 interactions	IFNGR2 LRRC25 CD33 CLDN2	1.62e-05	79	39	4	int:CXCL9
Interaction	DEFA1 interactions	C1QB CTSF PLXNB2 PLXNA1	4.11e-05	100	39	4	int:DEFA1
Interaction	TRH interactions	LCN2 TRH	5.45e-05	6	39	2	int:TRH
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	LHB SIGLEC14 CGB7 SIGLEC5 SIGLEC8 CD33 SIGLEC6 CGB3	1.09e-05	1192	42	8	chr19q13
Cytoband	19q13.32	LHB CGB7 CGB3	4.41e-05	74	42	3	19q13.32
Cytoband	19q13.3	SIGLEC5 CD33 SIGLEC6	6.00e-05	82	42	3	19q13.3
Cytoband	15q15.3	STRC STRCP1	2.42e-04	25	42	2	15q15.3
Cytoband	19p13.11	CPAMD8 LRRC25	2.06e-03	73	42	2	19p13.11
Cytoband	11q13	FGF3 CTSF	5.27e-03	118	42	2	11q13
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	PODNL1 CPAMD8 LRRC25 S1PR4	5.98e-03	797	42	4	chr19p13
Cytoband	Ensembl 112 genes in cytogenetic band chr15q15	STRC STRCP1	8.06e-03	147	42	2	chr15q15
Cytoband	Ensembl 112 genes in cytogenetic band chr11q13	FGF3 CTSF ZDHHC24	8.29e-03	454	42	3	chr11q13
GeneFamily	CD molecules\|C2-set domain containing\|Sialic acid binding Ig like lectins	SIGLEC14 SIGLEC5 SIGLEC8 CD33 SIGLEC6	7.07e-10	28	29	5	745
GeneFamily	Adenosine receptors\|V-set domain containing	SIGLEC14 SIGLEC5 SIGLEC8 CD33 SIGLEC6	5.58e-06	163	29	5	590
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	SIGLEC5 FCRL3 ART4 ALK CD33 SIGLEC6	3.20e-05	394	29	6	471
GeneFamily	Plexins	PLXNB2 PLXNA1	8.88e-05	9	29	2	683
GeneFamily	Endogenous ligands	LHB BMP8B TRH CGB3	5.28e-04	237	29	4	542
Coexpression	NABA_MATRISOME_ASSOCIATED	MST1 FGF3 C1QB CPAMD8 BMP8B CTSF CPN2 INSL6 PLXNB2 PLOD1 PLXNA1	1.89e-08	751	42	11	M5885
Coexpression	NABA_MATRISOME	MST1 FGF3 C1QB PODNL1 CPAMD8 BMP8B CTSF CPN2 INSL6 PLXNB2 PLOD1 PLXNA1	4.53e-08	1026	42	12	M5889
Coexpression	NABA_MATRISOME_ASSOCIATED	MST1 FGF3 C1QB BMP8B CTSF CPN2 INSL6 PLXNB2 PLOD1 PLXNA1	1.92e-07	738	42	10	MM17058
Coexpression	NABA_MATRISOME	MST1 FGF3 C1QB PODNL1 BMP8B CTSF CPN2 INSL6 PLXNB2 PLOD1 PLXNA1	3.69e-07	1008	42	11	MM17056
Coexpression	DESCARTES_FETAL_ADRENAL_MYELOID_CELLS	SIGLEC14 C1QB SIGLEC5 LRRC25 SIGLEC8 CD33	4.84e-07	185	42	6	M40148
Coexpression	DESCARTES_FETAL_PANCREAS_MYELOID_CELLS	SIGLEC14 C1QB SIGLEC5 LRRC25 PTCRA CD33	2.05e-06	237	42	6	M40264
Coexpression	HOEK_NK_CELL_2011_2012_TIV_3D_VS_0DY_ADULT_3D_DN	SCARF1 IFNGR2 SIGLEC14 LRRC25 PLXNB2 CD33	3.34e-06	258	42	6	M41144
Coexpression	DESCARTES_FETAL_LUNG_MYELOID_CELLS	SIGLEC14 C1QB SIGLEC5 LRRC25 CD33	9.47e-06	178	42	5	M40244
Coexpression	DESCARTES_MAIN_FETAL_MYELOID_CELLS	C1QB SIGLEC5 LRRC25 CD33	1.84e-05	98	42	4	M40071
Coexpression	DESCARTES_FETAL_KIDNEY_MYELOID_CELLS	C1QB SIGLEC5 LRRC25 CD33 SIGLEC6	2.52e-05	218	42	5	M40221
Coexpression	DESCARTES_FETAL_INTESTINE_MYELOID_CELLS	SIGLEC14 C1QB SIGLEC5 PTCRA CD33	3.25e-05	230	42	5	M40210
Coexpression	KORKOLA_CHORIOCARCINOMA	LHB CGB3	5.24e-05	7	42	2	M11690
Coexpression	DESCARTES_FETAL_CEREBELLUM_MICROGLIA	SIGLEC14 C1QB SIGLEC5 LRRC25 PTCRA SIGLEC8 CD33	7.22e-05	652	42	7	M40157
Coexpression	NABA_MATRISOME_PRIMARY_METASTATIC_COLORECTAL_TUMOR	C1QB PLXNB2 PLOD1	1.17e-04	59	42	3	M47989
Coexpression	HOWARD_NK_CELL_INACT_MONOV_INFLUENZA_A_INDONESIA_05_2005_H5N1_AGE_18_49YO_28DY_DN	IFNGR2 SIGLEC5 CD33	1.35e-04	62	42	3	M40989
Coexpression	CHEN_METABOLIC_SYNDROM_NETWORK	SIGLEC14 C1QB SIGLEC5 BMP8B LRCOL1 LRRC25 ART4 PLXNB2 SIGLEC6	1.96e-04	1316	42	9	MM1052
Coexpression	GSE11057_CD4_EFF_MEM_VS_PBMC_DN	IFNGR2 SIGLEC5 PLXNB2 PLOD1	2.61e-04	194	42	4	M3114
Coexpression	GSE21063_WT_VS_NFATC1_KO_3H_ANTI_IGM_STIM_BCELL_UP	SCARF1 LHB MST1 MZB1	2.88e-04	199	42	4	M8263
Coexpression	GSE29618_PRE_VS_DAY7_POST_TIV_FLU_VACCINE_PDC_UP	LHB CPN2 LCN2 PLOD1	2.93e-04	200	42	4	M5003
Coexpression	GSE5589_IL6_KO_VS_IL10_KO_LPS_STIM_MACROPHAGE_45MIN_UP	C1QB PLXNB2 PLOD1 CD33	2.93e-04	200	42	4	M6653
Coexpression	GSE43863_DAY6_EFF_VS_DAY150_MEM_LY6C_INT_CXCR5POS_CD4_TCELL_DN	IFNGR2 CTSF MZB1 S1PR4	2.93e-04	200	42	4	M9733
Coexpression	DESCARTES_FETAL_LIVER_MYELOID_CELLS	SIGLEC14 C1QB SIGLEC5 LRRC25	3.53e-04	210	42	4	M40229
Coexpression	RASHI_NFKB1_TARGETS	IFNGR2 LCN2	3.77e-04	18	42	2	M1171
Coexpression	DARWICHE_PAPILLOMA_PROGRESSION_RISK	SIGLEC14 SIGLEC5 SIGLEC6	4.35e-04	92	42	3	MM503
Coexpression	ZENG_GU_ICB_CONTROL_METAGENE_25_PRECICTIVE_ICB_RESPONSE	C1QB LRRC25 CD33 S1PR4	4.58e-04	225	42	4	MM17079
Coexpression	RASHI_NFKB1_TARGETS	IFNGR2 LCN2	4.68e-04	20	42	2	MM1114
CoexpressionAtlas	spleen	SCARF1 SIGLEC14 SIGLEC5 FCRL3 LRRC25 PTCRA ART4 CD33 S1PR4	5.67e-09	315	40	9	spleen
CoexpressionAtlas	Myeloid Cells, MF.Microglia.CNS, CD45low CD11b+ F4/80+, Brain, avg-3	C1QB CTSF LRRC25 PLXNB2 PLOD1 CD33	1.04e-04	406	40	6	GSM854326_500
CoexpressionAtlas	Myeloid Cells, MF.Thio5.II+480int.PC, CD115+ MHC II+ F480lo SiglecF- CD11c+, Peritoneal Cavity, avg-3	C1QB LRRC25 PLXNB2 PLOD1 PLXNA1 CD33	1.48e-04	433	40	6	GSM605856_500
CoexpressionAtlas	Myeloid Cells, MF.Thio5.II-480int.PC, CD115+ MHCII- F480int SiglecF- CD11c+, Peritoneal Cavity, avg-3	C1QB LRRC25 PLXNB2 PLOD1 PLXNA1 CD33	1.56e-04	437	40	6	GSM605865_500
CoexpressionAtlas	Myeloid Cells, MF.Thio5.II-480hi.PC, CD115+ MHC II- F480hi Siglec F-, Peritoneal Cavity, avg-3	C1QB LRRC25 PLXNB2 PLOD1 PLXNA1 CD33	1.64e-04	441	40	6	GSM605862_500
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macro_CHIT1\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	IFNGR2 SIGLEC14 C1QB LRRC25 PTCRA SIGLEC8	3.10e-08	198	42	6	243109377d62d20c69e9d1fedc252156e90cda1e
ToppCell	Tracheal-10x3prime_v2-Immune_Myeloid-Macrophage_other\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	SIGLEC14 C1QB LRRC25 PTCRA SIGLEC8 CD33	3.29e-08	200	42	6	3cfb28299a55fc1c150262a7333c59a48ae65ad1
ToppCell	droplet-Thymus-nan-24m-Myeloid-Macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH PLXNB2 CD33	6.19e-07	174	42	5	44c21521991ad4789783d73d5aa4993a22876886
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l9\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PODNL1 PTCRA INSL6 CLDN2 S1PR4	6.73e-07	177	42	5	44c38e572a9e9678c2dbb3e8b4748e7e28d404b7
ToppCell	droplet-Spleen-SPLEEN-30m-Myeloid-macrophage\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH PLXNB2 PLXNA1	6.92e-07	178	42	5	6c1b5087581ca8cea976d89ea6f34088c8fc3668
ToppCell	5'-Adult-Appendix-Hematopoietic-Myeloid\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	C1QB LRRC25 SIGLEC8 CD33 SIGLEC6	7.52e-07	181	42	5	79102845baee5af583eec24e9f91dfec46ab7de3
ToppCell	PCW_05-06-Hematologic_Myeloid-Hem_Myeloid_dendritic-im_migrating_dendritic_(5)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	SIGLEC14 C1QB LRRC25 PTCRA CD33	8.60e-07	186	42	5	73185d48c874e18dd2e2eeea67c32d3182ea88a5
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I-C\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LHB C1QB PTCRA SIGLEC8 CD33	9.55e-07	190	42	5	259085b9731902ca0956233afafe1db6fc98e851
ToppCell	VE-naiveBc-\|VE / Condition, Cell_class and T cell subcluster	IFNGR2 SIGLEC14 FCRL3 MZB1 TAS1R3	1.01e-06	192	42	5	bca2aec4811627225fccd92abe2f3b1ba729c9ce
ToppCell	VE-naiveBc\|VE / Condition, Cell_class and T cell subcluster	IFNGR2 SIGLEC14 FCRL3 MZB1 TAS1R3	1.01e-06	192	42	5	87cdda9a170f6f2fa56d0ed1d3fd2f93bfe09aa1
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c6-VCAN\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	IFNGR2 SIGLEC5 LRRC25 PLXNB2 CD33	1.03e-06	193	42	5	52f5b0fbb8ca706206c65e7edbb1ddbd380aebae
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c4-CD14-CD16\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	IFNGR2 C1QB SIGLEC5 LRRC25 CD33	1.08e-06	195	42	5	3a30479857fc2805df92655c9599389559b1995d
ToppCell	11.5-Airway-Immune-Hematopoietic,_Macrophage\|Airway / Age, Tissue, Lineage and Cell class	SIGLEC14 C1QB SIGLEC5 LRRC25 CD33	1.11e-06	196	42	5	f73573b5d9c735f2a2c718472b7d12b10f2a3718
ToppCell	3'-GW_trimst-1-LargeIntestine-Hematopoietic\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SIGLEC14 C1QB LRRC25 MZB1 CD33	1.11e-06	196	42	5	5dbe38aef369811d981c0109829563ac66dcc684
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Myeloid-Monocytic-Classical_Monocyte-Mono_c2-CD14-HLA-DPB1\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	IFNGR2 SIGLEC14 LRRC25 PLXNB2 CD33	1.14e-06	197	42	5	321ccd20b0bb03c99a00452ac3c637ee3aa73ecf
ToppCell	Tracheal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macro_interstitial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	SIGLEC14 C1QB SIGLEC5 LRRC25 PTCRA	1.14e-06	197	42	5	780ab4a9f1dbf1f58b70a716ba2949c4f51b9295
ToppCell	Monocytes\|World / Immune cells in Kidney/Urine in Lupus Nephritis	IFNGR2 C1QB LRRC25 PLXNB2 CD33	1.17e-06	198	42	5	8beccf03c9ec9cd02a96107a9d7ca9a6764c6a61
ToppCell	Caecum-(6)_Macrophage-(61)_LYVE1_Macrophage\|Caecum / shred on region, Cell_type, and subtype	SIGLEC14 C1QB LRRC25 ART4 CD33	1.17e-06	198	42	5	e684c3934c163aef4d284b69435832d2c9614f2a
ToppCell	Caecum-Macrophage-LYVE1_Macrophage\|Caecum / Region, Cell class and subclass	SIGLEC14 C1QB LRRC25 ART4 CD33	1.17e-06	198	42	5	a92c0cacb775aca6bbb302bd9e22c081a112a44d
ToppCell	Tracheal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macro_CHIT1\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	C1QB LRRC25 PTCRA SIGLEC8 CD33	1.20e-06	199	42	5	368e2bafae00ce8e9c6ea480f81b78f96b680acd
ToppCell	Tracheal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macrophage_intravascular\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	SIGLEC14 C1QB LRRC25 SIGLEC8 CD33	1.23e-06	200	42	5	c210b98a75ab5d899d7278bc9b577f76a0b3970c
ToppCell	severe-unassigned\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	MST1 LCN2 GRM2 TAS1R3	6.43e-06	128	42	4	bef9cf0078fa8498d63f0723f1fa4a3c92405e10
ToppCell	frontal_cortex-Non-neuronal-macrophage-Macrophage-PVM_Mrc1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	C1QB LRRC25 TRH CD33	1.14e-05	148	42	4	d3ea907f8f408e9bb97ed223a3089e403e35f911
ToppCell	E16.5-samps-Myeloid-Fetal_macrophage\|E16.5-samps / Age Group, Lineage, Cell class and subclass	C1QB LRRC25 TRH CD33	1.30e-05	153	42	4	e9567966fe4426176e2f2dc0be4832c769c9903a
ToppCell	primary_visual_cortex-Non-neuronal-macrophage-Macrophage-Microglia_Siglech\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	C1QB LRRC25 TRH CD33	1.37e-05	155	42	4	f59ca572556c17c606604da1b0331710d4751e54
ToppCell	primary_visual_cortex-Non-neuronal-macrophage-Macrophage\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	C1QB LRRC25 TRH CD33	1.40e-05	156	42	4	4b6b59a1638a7218a9ed9bd702c04d9f51dbc7aa
ToppCell	primary_visual_cortex-Non-neuronal-macrophage\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	C1QB LRRC25 TRH CD33	1.40e-05	156	42	4	60a8a8584d3c80c4ceb433cb820de914e33e3500
ToppCell	facs-Lung-Endomucin-24m-Myeloid-Neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SIGLEC5 LRRC25 LCN2 CD33	1.48e-05	158	42	4	0ed844ab625351a46b74edddf082279ed1bae5c6
ToppCell	droplet-Spleen-nan-24m-Myeloid-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 LCN2 CD33	1.48e-05	158	42	4	e1a8dba5a88bc3ce112829c5ecb112cbbee5b078
ToppCell	facs-Lung-Endomucin-24m-Myeloid-neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SIGLEC5 LRRC25 LCN2 CD33	1.48e-05	158	42	4	b3a810314e253b4fd0f578e759c36fdd21722934
ToppCell	droplet-Spleen-nan-24m-Myeloid\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 LCN2 CD33	1.48e-05	158	42	4	72e4f8ae137a7dddee0dc6236532e0711065e6af
ToppCell	droplet-Kidney-nan-3m-Myeloid-nan\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB SIGLEC5 LRRC25 TRH	1.51e-05	159	42	4	bea6e96ba40ebfc1e38687bfa1c61fe227c5a84d
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZDHHC24 LCN2 MZB1 S1PR4	1.55e-05	160	42	4	1cb6f42b68c9e41e8edae0de8f0d8371c4620b04
ToppCell	frontal_cortex-Non-neuronal-macrophage-Macrophage-Microglia_Siglech\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	C1QB LRRC25 TRH CD33	1.55e-05	160	42	4	c3f2f362e5d0602bb997e8367b4c9a8fe88e4ea8
ToppCell	PCW_05-06-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_myeloid_progenitor1_(6)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	C1QB BMP8B LRRC25 CD33	1.55e-05	160	42	4	7f1b58641ba149d20420fafad34ba78a65a2c701
ToppCell	facs-Liver-Liver_non-hepato/SCs\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZDHHC24 LCN2 MZB1 S1PR4	1.55e-05	160	42	4	ebefde92db400cbe68d9ce31545a0308e0afbde1
ToppCell	droplet-Fat-Mat-18m-Myeloid-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH CD33	1.59e-05	161	42	4	8c62ae3fcf304db0f71633e328ceba81a70f03c4
ToppCell	facs-MAT-Fat-24m-Myeloid-myeloid_cell\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 LCN2 CD33	1.59e-05	161	42	4	65888250b8c1da6a8f9b5376e086a3769a1cbbd8
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_macrophage-im_macrophage_(16)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	C1QB LRRC25 PTCRA CD33	1.63e-05	162	42	4	2b47fd256490d0c2d9ad5950aa26410aeb6ec995
ToppCell	facs-Heart-LV-24m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 PTCRA CD33	1.63e-05	162	42	4	5dfdb4e227e5d7d72dbe8fe032791fddb0be064d
ToppCell	facs-Heart-LV-24m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 PTCRA CD33	1.63e-05	162	42	4	7f26135b884144473bbccaf3881c8cf2ba4fa05a
ToppCell	facs-MAT-Fat-3m-Myeloid-myeloid_cell\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH CD33	1.67e-05	163	42	4	5fc836444bc156c8248abee001b0ecbe43f980c9
ToppCell	frontal_cortex-Non-neuronal-macrophage\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	C1QB LRRC25 TRH CD33	1.67e-05	163	42	4	b89f586b444f90047c8ce407f53847fd1ee7cca3
ToppCell	frontal_cortex-Non-neuronal-macrophage-Macrophage\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	C1QB LRRC25 TRH CD33	1.67e-05	163	42	4	cbe9b4c4b2e42e9f92a57ed66758af93434db5bb
ToppCell	droplet-Kidney-nan-21m-Myeloid-CD45____macrophage\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH CD33	1.71e-05	164	42	4	d4cdcd61e8c28b3fb912cef8837cc1a49678a729
ToppCell	droplet-Limb_Muscle-nan-18m-Myeloid-macrophage\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH CD33	1.71e-05	164	42	4	8d089844896e84935eab705ebe54f125c4b6d9ca
ToppCell	droplet-Limb_Muscle-nan-18m-Myeloid\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH CD33	1.71e-05	164	42	4	17fb1421476ba44999b1165f2576514f74c1f882
ToppCell	droplet-Kidney-nan-21m-Myeloid-macrophage\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH CD33	1.75e-05	165	42	4	9852a4cb680af39c92c7d2d5e5fa8dc04e6602aa
ToppCell	PND28-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	C1QB CTSF TRH CD33	1.75e-05	165	42	4	47e716ce8dc283d406352c1909e09362fcb9e3a3
ToppCell	facs-Diaphragm-Limb_Muscle-3m-Myeloid\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH CD33	1.75e-05	165	42	4	518ee34c18065100a2f2c6e407d3a7866b908593
ToppCell	facs-Diaphragm-Limb_Muscle-3m-Myeloid-nan\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH CD33	1.75e-05	165	42	4	becb8f726b84509ec29c75b530a3fe757651301d
ToppCell	droplet-Kidney-nan-21m-Myeloid\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH CD33	1.75e-05	165	42	4	c629ed33ff14834c32cc1a91116fb079f7aaa94d
ToppCell	PND28-Immune-Immune_Myeloid-Monocytic-Macrophage-IM\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	C1QB CTSF TRH CD33	1.75e-05	165	42	4	fe2135fdacf3807eb4b5ea5e790febfb8cd54335
ToppCell	facs-Diaphragm-Limb_Muscle-3m-Myeloid-macrophage\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH CD33	1.75e-05	165	42	4	ae8dd9c00f96590f27ed21cd6314f4577e00e312
ToppCell	facs-Heart-RA-24m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 LCN2 MZB1	1.75e-05	165	42	4	995f1524965a4314938f27165166f0aaff9dea02
ToppCell	droplet-Limb_Muscle-nan-3m-Myeloid\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH CD33	1.79e-05	166	42	4	cd22d4222bc748942ed570a8978cb015e3b55388
ToppCell	Immune_cells\|World / Lineage and Cell class	LCN2 MZB1 CD33 S1PR4	1.79e-05	166	42	4	f20b58528749ee88fba3ccdaf3f3fa0d06cb9a91
ToppCell	droplet-Limb_Muscle-nan-3m-Myeloid-macrophage\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH CD33	1.79e-05	166	42	4	5f6031420bffb1813fe4989021f9f3a54a7243b0
ToppCell	droplet-Tongue-TONGUE-1m-Myeloid-Langerhans_cell\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH CD33	1.84e-05	167	42	4	e85d97f8b0127663a3295db2b22b8488c0148455
ToppCell	droplet-Tongue-TONGUE-1m-Myeloid\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH CD33	1.84e-05	167	42	4	ac21c7112b592e30473e693a2bbee81ff0bb0160
ToppCell	facs-Kidney-nan-3m-Myeloid-macrophage\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH CD33	1.84e-05	167	42	4	991a93e1075d562b7391f0689b2f62c1351d48d1
ToppCell	droplet-Limb_Muscle-nan-3m-Myeloid-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH CD33	1.84e-05	167	42	4	e984278c209cc52dbb752686db772e713afab33d
ToppCell	facs-Kidney-nan-3m-Myeloid\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH CD33	1.84e-05	167	42	4	f22d1471c785b30d096ec5cdc68974e850ed7de0
ToppCell	facs-Kidney-nan-3m-Myeloid-macrophage\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH CD33	1.84e-05	167	42	4	934905aeaafbc215ec8f6a7903498b0e258b9220
ToppCell	droplet-Tongue-TONGUE-1m-Myeloid-Langerhans_cell\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH CD33	1.84e-05	167	42	4	a54e200789db14f41c9fc8d21cd7fa7cedde77ad
ToppCell	PCW_07-8.5-Immune_Lymphocytic-Immune_Lymphocytic_B-im_B_cell_(15)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	BMP8B MZB1 CD33 S1PR4	1.88e-05	168	42	4	2ec53f91de3bff8a106430a78b81ee6870f0c55e
ToppCell	facs-Heart-RV-3m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH CD33	1.88e-05	168	42	4	8ee57814c7e9d45444f48b6b269c4d535bc4d5e1
ToppCell	droplet-Lung-21m-Hematologic-myeloid-interstitial_macrophage-interstitial_macrophage_l12\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C1QB LRRC25 TRH CD33	1.88e-05	168	42	4	aaafa7243c44e6852d92e3445335fc4a1018f416
ToppCell	facs-Heart-RV-3m-Myeloid\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH CD33	1.88e-05	168	42	4	c1a5f4f4d32a1f8583048db709a7037cc9357ad8
ToppCell	facs-Heart-RV-3m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH CD33	1.88e-05	168	42	4	a405f0de70293f68b4e000c1fc8a9ad33d56539a
ToppCell	droplet-Lung-21m-Hematologic-myeloid-interstitial_macrophage\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C1QB LRRC25 TRH CD33	1.88e-05	168	42	4	06787d4f08ddf052127404a0ea6a85e1b048e206
ToppCell	BAL-Mild-Lymphocyte-B\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FCRL3 MZB1 TAS1R3 SIGLEC6	1.92e-05	169	42	4	307571e57c3bfdf15f0fe1a8b36585e8e4f8a207
ToppCell	facs-Trachea-24m-Hematologic-myeloid-tracheal_macrophage-macrophage_of_tracheal_l12\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C1QB LRRC25 TRH CD33	1.92e-05	169	42	4	8180aeda13c511260d0542a94156059d558848a7
ToppCell	facs-Trachea-3m-Hematologic-myeloid-tracheal_macrophage-macrophage_of_tracheal_l12\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C1QB LRRC25 TRH CD33	1.97e-05	170	42	4	f524b73d65941ebef7671c46df4362a3f15d24fc
ToppCell	droplet-Trachea-3m-Hematologic-myeloid-granulocyte-granulocyte_l12-45\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C1QB LRRC25 TRH CD33	1.97e-05	170	42	4	e028e22ad051c2628248b212b5d28b891e0ee782
ToppCell	facs-Trachea-18m-Hematologic-myeloid-tracheal_macrophage-macrophage_of_tracheal_l12\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C1QB LRRC25 TRH CD33	2.01e-05	171	42	4	26755e43d94e934106fc19ab929e4d34c17d6cba
ToppCell	droplet-Heart-4Chambers-18m-Hematologic-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH CD33	2.01e-05	171	42	4	4935a95d11ac997d183fab32cbaad837bf0a512b
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-Monocytes\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SIGLEC14 SIGLEC5 LRRC25 S1PR4	2.06e-05	172	42	4	cf46810dd1072b6f2171e5d9530351ddc79a055b
ToppCell	3'-GW_trimst-2-SmallIntestine-Hematopoietic-B_cells-Immature_B\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SIGLEC14 FCRL3 MZB1 S1PR4	2.06e-05	172	42	4	0bcb960c5ab0d3cbbdf6235b6f28327ea60ba3e3
ToppCell	droplet-Heart-4Chambers-18m-Hematologic-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH CD33	2.06e-05	172	42	4	19ccac3d88382b8b2379d14525b2204c7407cb3b
ToppCell	facs-Trachea-nan-24m-Myeloid-macrophage\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH MZB1	2.06e-05	172	42	4	40b4313dd6081d0a48fc3d0a5cb8ead4d646aae0
ToppCell	facs-Trachea-18m-Hematologic-myeloid\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C1QB LRRC25 TRH CD33	2.06e-05	172	42	4	c260680f5455fce133b7b4158b4197fc76115779
ToppCell	E16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	C1QB LRRC25 TRH CD33	2.06e-05	172	42	4	714172f31abd0d25261df6115ec6a9df491fa14b
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Myeloid-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH CD33	2.11e-05	173	42	4	a664dbd7fb55b1c4309fa5f9425bc83924dac545
ToppCell	facs-Brain_Myeloid-Cerebellum-24m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FGF3 LCN2 INSL6 ART4	2.11e-05	173	42	4	ef862e1d626bbc33191b433f483addff7f75ba16
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Myeloid-macrophage\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH CD33	2.11e-05	173	42	4	054f64462b648ba6b4b28b48c716dc01b2ddd790
ToppCell	facs-Trachea-nan-3m-Myeloid-nan\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH CD33	2.11e-05	173	42	4	e4eb2ac2cee16bfa8eabc938f8030ee161c972c5
ToppCell	facs-Trachea-nan-3m-Myeloid\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH CD33	2.11e-05	173	42	4	371515471459307a3b2adce735263b4aac828956
ToppCell	facs-Trachea-nan-3m-Myeloid-macrophage\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH CD33	2.11e-05	173	42	4	4e9b6c71030ae0d63d54e7255e4a10b25970fcc4
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Myeloid\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH CD33	2.11e-05	173	42	4	9a8fec9a08bb61456a4ea43ae1316bd3e197a773
ToppCell	facs-Heart-LA-3m-Myeloid\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH CD33	2.16e-05	174	42	4	30c083fe4711735e83dccfd00fcd746ae673d353
ToppCell	facs-Heart-LV-3m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH CD33	2.16e-05	174	42	4	54166a0faf748cccb6406c2c268e1e6e21caf6d0
ToppCell	facs-Heart-LA-3m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH CD33	2.16e-05	174	42	4	46d19c1144fff19be682b7ba59d4c3e014f79e15
ToppCell	facs-Heart-LA-3m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH CD33	2.16e-05	174	42	4	1802a52552256d1e25d8b328ba62dcfe41671900
ToppCell	E16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	C1QB LRRC25 TRH CD33	2.16e-05	174	42	4	0a8fa44604be19fbac722ebc6d1cd72b71be7022
ToppCell	facs-Trachea-3m-Hematologic-myeloid-tracheal_macrophage\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C1QB LRRC25 TRH CD33	2.16e-05	174	42	4	d67fc8e30cc67fff8f7fdeaccb409d12ca0992c1
ToppCell	facs-Heart-LV-3m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH CD33	2.16e-05	174	42	4	dc8a238ec1d954bec0f8eb67c04a61734c96f5b5
ToppCell	facs-Trachea-24m-Hematologic-myeloid\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C1QB LRRC25 TRH CD33	2.16e-05	174	42	4	2f25fba5225f4687df4396645e94565a640b5583
ToppCell	facs-Heart-LV-3m-Myeloid\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QB LRRC25 TRH CD33	2.21e-05	175	42	4	5d106ef542b97f97aeb19179e3f72963ead1e82a
ToppCell	PND07-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	C1QB LRRC25 TRH CD33	2.21e-05	175	42	4	d983e80eeb11f341c564ea684e2b0b585a90ae58
Computational	Peptide hormones.	LHB TRH CGB3	1.26e-05	28	18	3	MODULE_382
Computational	Genes in the cancer module 55.	MST1 C1QB CPN2 LCN2 GRM2 CD33 S1PR4	2.42e-04	832	18	7	MODULE_55
Computational	Heart, liver, kidney and pancreas metabolic and xenobiotic response genes.	MST1 C1QB CPN2 LCN2 GRM2 CD33 S1PR4	2.47e-04	835	18	7	MODULE_88
Computational	Secreted signaling molecules.	LHB TRH CGB3	1.83e-03	149	18	3	MODULE_92
Computational	Liver genes - metabolism and xenobiotics.	MST1 C1QB CTSF CPN2 S1PR4	1.88e-03	563	18	5	MODULE_23
Drug	AC1L8TUU	LHB PTCRA ART4 S1PR4	9.07e-06	75	40	4	CID000432637
Drug	baclofen	LHB TRH GRM2 ART4 PLOD1	2.04e-05	191	40	5	CID000002284
Drug	Fluorometholone [426-13-1]; Up 200; 10.6uM; HL60; HT_HG-U133A	TRH PTCRA MZB1 SIGLEC8 ALK	2.15e-05	193	40	5	2509_UP
Drug	Dubinidine [22964-77-8]; Up 200; 14.6uM; PC3; HT_HG-U133A	FGF3 PODNL1 CPN2 GRM2 CD33	2.20e-05	194	40	5	5774_UP
Drug	Methylergometrine maleate [113-42-8]; Up 200; 8.8uM; PC3; HT_HG-U133A	CTSF CPN2 GRM2 PTCRA SIGLEC6	2.31e-05	196	40	5	6704_UP
Drug	Bupivacaine hydrochloride [18010-40-7]; Up 200; 12.4uM; PC3; HT_HG-U133A	FGF3 PODNL1 CTSF CD33 SIGLEC6	2.31e-05	196	40	5	5112_UP
Drug	Phthalylsulfathiazole [85-73-4]; Up 200; 10uM; MCF7; HT_HG-U133A	FGF3 C1QB CPN2 TRH PTCRA	2.37e-05	197	40	5	5249_UP
Drug	Molindone hydrochloride [15622-65-8]; Up 200; 12.8uM; HL60; HT_HG-U133A	SCARF1 RDH5 CTSF PTCRA SIGLEC8	2.43e-05	198	40	5	2917_UP
Drug	Novobiocin sodium salt [1476-53-5]; Up 200; 6.4uM; HL60; HT_HG-U133A	CPN2 PTCRA ART4 MZB1 ALK	2.49e-05	199	40	5	2990_UP
Drug	Turpentine	LHB MST1 CGB3	3.74e-05	37	40	3	ctd:D014425
Drug	maleic acid	LCN2 CLDN2	4.49e-05	6	40	2	ctd:C030272
Drug	isoguvacine	UTS2R TRH PLOD1	6.77e-05	45	40	3	CID000003765
Drug	Factrel	LHB CGB7 TRH PLOD1 CGB3	6.83e-05	246	40	5	CID000036523
Drug	polysialoganglioside	SIGLEC5 SIGLEC8 CD33	9.30e-05	50	40	3	CID006450319
Disease	sialic acid-binding Ig-like lectin 6 measurement	SIGLEC5 SIGLEC8 SIGLEC6	1.49e-07	8	42	3	EFO_0008285
Disease	sialic acid-binding Ig-like lectin 14 measurement	SIGLEC14 SIGLEC5 SIGLEC6	5.85e-07	12	42	3	EFO_0008284
Disease	autosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)	STRC STRCP1	1.98e-06	2	42	2	DOID:0110471 (implicated_via_orthology)
Disease	lutropin subunit beta measurement	LHB CGB3	5.93e-06	3	42	2	EFO_0801773
Disease	cathepsin F measurement	CTSF ZDHHC24	7.08e-05	9	42	2	EFO_0022038
Disease	luteinizing hormone measurement	LHB CGB3	7.08e-05	9	42	2	EFO_0007002
Disease	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 measurement	SIGLEC14 SIGLEC5	8.84e-05	10	42	2	EFO_0801544
Disease	human Chorionic Gonadotropin measurement	LHB CGB3	1.53e-04	13	42	2	EFO_0008156
Disease	Hypothermia, natural	LHB TRH	1.78e-04	14	42	2	C0020672
Disease	Hypogonadotropic hypogonadism	LHB CGB3	2.05e-04	15	42	2	C0271623
Disease	Primary hypogonadism	LHB CGB3	2.05e-04	15	42	2	C0948896
Disease	Hypogonadism, Isolated Hypogonadotropic	LHB CGB3	2.05e-04	15	42	2	C3489396
Disease	Hypogonadism	LHB CGB3	2.34e-04	16	42	2	C0020619
Disease	Tachycardia	LHB TRH	2.98e-04	18	42	2	C0039231
Disease	Tachyarrhythmia	LHB TRH	2.98e-04	18	42	2	C0080203
Disease	Alcoholic Intoxication, Chronic	LHB TRH GRM2 ALK	5.68e-04	268	42	4	C0001973
Disease	Bradycardia	LHB TRH	6.29e-04	26	42	2	C0428977
Disease	Malignant neoplasm of breast	MST1 FGF3 C1QB UTS2R FCRL3 PLOD1 ALK	7.34e-04	1074	42	7	C0006142
Disease	thioredoxin domain-containing protein 12 measurement	MST1 GRM2	1.42e-03	39	42	2	EFO_0008298
Disease	rheumatoid arthritis, anti-citrullinated protein antibody seropositivity, rheumatoid factor seropositivity measurement	IFNGR2 FCRL3 SIGLEC6	1.83e-03	170	42	3	EFO_0000685, EFO_0007791, EFO_0007837
Disease	selective IgA deficiency disease	CPAMD8 FCRL3	1.97e-03	46	42	2	EFO_1001929
Disease	severe acute respiratory syndrome (is_marker_for)	LHB C1QB	2.05e-03	47	42	2	DOID:2945 (is_marker_for)
Disease	Male sterility	LHB TAS1R3	2.14e-03	48	42	2	C0917731
Disease	Male infertility	LHB TAS1R3	2.14e-03	48	42	2	C0021364
Disease	Subfertility, Male	LHB TAS1R3	2.14e-03	48	42	2	C0848676

Protein segments in the cluster

Peptide	Gene	Start	Entry
MLPGAWLLWTSLLLL	CPN2	1	P22792
MGSLLALLALLLLWG	GRM2	1	Q14416
MAGPGWTLLLLLLLL	LRCOL1	1	A6NCL2
MAGTWLLLLLALGCP	PTCRA	1	Q6ISU1
MGGTLAWTLLLPLLL	LRRC25	1	Q8N386
GLLLLLLLSMGGAWA	LHB	6	P01229
MPLLLLLPLLWAGAL	CD33	1	P20138
MGLIWLLLLSLLEPG	FGF3	1	P11487
GLLLLLLLSMGGTWA	CGB7	6	P0DN87
LLLLLLLLLLLPGMW	PLXNA1	11	Q9UIW2
LLLLLLPGMWAEAGL	PLXNA1	16	Q9UIW2
MALQLWALTLLGLLG	PLXNB2	1	O15031
MRPLLLLALLGWLLL	PLOD1	1	Q02809
MPLGLLWLGLALLGA	LCN2	1	P80188
LAMWPSLLLLLLLPG	PODNL1	6	Q6PEZ8
GLLLLLLLSMGGTWA	CGB3	6	P0DN86
MSGALLWPLLPLLLL	CPAMD8	1	Q8IZJ3
MAPWLQLLSLLGLLP	CTSF	1	Q9UBX1
PWGSIPVLMLLLLLG	C1QB	6	P02746
MLLWLLLLILTPGRE	FCRL3	1	Q96P31
MEPGPALAWLLLLSL	LYPD6	1	Q86Y78
MRPTLLWSLLLLLGV	IFNGR2	1	P38484
LGLLGTLVAMLLPSW	CLDN2	16	P57739
MGWLPLLLLLTQCLG	MST1	1	P26927
MTALPGPLWLLGLAL	BMP8B	1	P34820
IGLCWLLAALLGMLP	S1PR4	166	O95977
LLAALLGMLPLLGWN	S1PR4	171	O95977
MPRLLRLSLLWLGLL	INSL6	1	Q9Y581
MLPLLLLPLLWGGSL	SIGLEC5	1	O15389
EMLPLLLPLLWAGAL	SIGLEC6	11	O43699
MLLLLLLLPLLWGTK	SIGLEC8	1	Q9NYZ4
MWLPLLLGALLWAVL	RDH5	1	Q92781
MALSLWPLLLLLLLL	STRC	1	Q7RTU9
MGLGLLLPLLLLWTR	SCARF1	1	Q14162
MGAIGLLWLLPLLLS	ALK	1	Q9UM73
MLGPAVLGLSLWALL	TAS1R3	1	Q7RTX0
MRAALWTLGLGPLLL	SCART1	1	Q4G0T1
LLLLPWLMLLTGRVS	ZDHHC24	176	Q6UX98
LGTWLLALLLTLPVM	UTS2R	171	Q9UKP6
MPGPWLLLALALTLN	TRH	1	P20396
MALSLWPLLLLLLLL	STRCP1	1	A6NGW2
MLPLLLLPLLWGGSL	SIGLEC14	1	Q08ET2
TMRIWLLGGLLPFLL	ART4	21	Q93070
MRLSLPLLLLLLGAW	MZB1	1	Q8WU39