Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	regulation of sperm capacitation	TCP11X1 TCP11 TCP11X2	7.84e-06	7	127	3	GO:1902490
GeneOntologyCellularComponent	HOPS complex	VPS39 VPS33A HOOK2	8.32e-05	14	131	3	GO:0030897
Domain	ARM-type_fold	DCAF1 CAND1 TOGARAM2 FRYL PPP6R1 IPO4 TRRAP MROH6 AP1G1 PKP3 EIF4G2 PUM3 USP35 AGBL1	7.86e-08	339	127	14	IPR016024
Domain	ARM-like	DCAF1 CAND1 TOGARAM2 FRYL IPO4 TRRAP MROH6 AP1G1 PKP3 PUM3 USP35 AGBL1	3.21e-07	270	127	12	IPR011989
Domain	-	DCAF1 CAND1 TOGARAM2 FRYL IPO4 TRRAP MROH6 AP1G1 PKP3 PUM3	2.86e-06	222	127	10	1.25.10.10
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	DENND4A DHX37 PARG OBSL1 PPP6R1 DDX55 ECT2 TYK2 TAOK3 DST AP1G1 TUBGCP3 TNFAIP2 HOOK2 ZBTB11 LRRC41	3.92e-09	650	132	16	38777146
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	DCAF1 CAND1 UGGT1 OBSL1 EVPL SAMHD1 PPP6R1 IPO4 TYK2 THEM6 GTF2I PKP3 NUP210 CCAR2 HOOK2 SNTA1	9.61e-07	974	132	16	28675297
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	MYCBP2 DHX37 UGGT1 FRYL IPO4 TRRAP GTF2I DST MDN1 NUP210 CCAR2 PUM3 ZBTB11	1.34e-06	653	132	13	22586326
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	DENND4A MYCBP2 SAMHD1 ECT2 RYR1 DST TUBGCP3 EIF4G2 PUM3 MYOM2 HOOK2	3.33e-06	497	132	11	23414517
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	DCAF1 CAND1 DSG1 MYCBP2 DHX37 ZNF185 IPO4 ECT2 TRRAP ORC1 GTF2I DST MDN1 AP1G1 TUBGCP3 EIF4G2 CCAR2 PUM3	3.84e-06	1353	132	18	29467282
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	MYCBP2 VPS39 DHX37 UGGT1 CEP290 COQ8B MDN1 CEP250 IMP4 NUP210 TUBGCP3 PUM3 LRRC41	6.38e-06	754	132	13	33060197
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	CAND1 MYCBP2 DHX37 SAMHD1 DDX55 ECT2 TRRAP MDN1 PRPF4 IMP4 CCAR2 PUM3 ZBTB11	6.85e-06	759	132	13	35915203
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	CAND1 DSG1 MYCBP2 UGGT1 CEP290 OBSL1 TRRAP DST MDN1 SACS PRPF4 PKP3 NUP210 CCAR2 PUM3	8.53e-06	1024	132	15	24711643
Pubmed	Clathrin-dependent mechanisms modulate the subcellular distribution of class C Vps/HOPS tether subunits in polarized and nonpolarized cells.	VPS39 VPS33A AP1G1	1.15e-05	12	132	3	21411634
Pubmed	ACTH receptor, CYP11A1, CYP17 and CYP21A2 genes are expressed in skin.	CYP17A1 CYP21A2	1.43e-05	2	132	2	8675607
Pubmed	Epoxidation activities of human cytochromes P450c17 and P450c21.	CYP17A1 CYP21A2	1.43e-05	2	132	2	25386927
Pubmed	Interaction of FAM5C with UDP-glucose:glycoprotein glucosyltransferase 1 (UGGT1): Implication of N-glycosylation in FAM5C secretion.	BRINP3 UGGT1	1.43e-05	2	132	2	28351617
Pubmed	Is the unique benzodiazepine structure interacting with CYP enzymes to affect steroid synthesis in vitro?	CYP17A1 CYP21A2	1.43e-05	2	132	2	32991989
Pubmed	Determinants of lentiviral Vpx-CRL4 E3 ligase-mediated SAMHD1 degradation in the substrate adaptor protein DCAF1.	DCAF1 SAMHD1	1.43e-05	2	132	2	31003777
Pubmed	A novel DCAF1-binding motif required for Vpx-mediated degradation of nuclear SAMHD1 and Vpr-induced G2 arrest.	DCAF1 SAMHD1	1.43e-05	2	132	2	22776683
Pubmed	Exploration of CYP21A2 and CYP17A1 polymorphisms and preeclampsia risk among Chinese Han population: a large-scale case-control study based on 5021 subjects.	CYP17A1 CYP21A2	1.43e-05	2	132	2	32977860
Pubmed	Role of multifunctional transcription factor TFII-I and putative tumour suppressor DBC1 in cell cycle and DNA double strand damage repair.	GTF2I CCAR2	1.43e-05	2	132	2	24231951
Pubmed	Minor activities and transition state properties of the human steroid hydroxylases cytochromes P450c17 and P450c21, from reactions observed with deuterium-labeled substrates.	CYP17A1 CYP21A2	1.43e-05	2	132	2	22873692
Pubmed	Synthesis of halogenated pregnanes, mechanistic probes of steroid hydroxylases CYP17A1 and CYP21A2.	CYP17A1 CYP21A2	1.43e-05	2	132	2	22001566
Pubmed	Hox2 Genes Are Required for Tonotopic Map Precision and Sound Discrimination in the Mouse Auditory Brainstem.	HOXA2 HOXB2	1.43e-05	2	132	2	28052248
Pubmed	Role of microsomal steroid hydroxylases in Δ7-steroid biosynthesis.	CYP17A1 CYP21A2	1.43e-05	2	132	2	23586722
Pubmed	The double face of the histone variant H3.3.	H3Y1 H3Y2	1.43e-05	2	132	2	21263457
Pubmed	The enantiomer of progesterone (ent-progesterone) is a competitive inhibitor of human cytochromes P450c17 and P450c21.	CYP17A1 CYP21A2	1.43e-05	2	132	2	12464252
Pubmed	A novel nonsense mutation in CEP290 induces exon skipping and leads to a relatively mild retinal phenotype.	CEP290 MERTK	1.43e-05	2	132	2	20130272
Pubmed	Identification and characterization of two novel primate-specific histone H3 variants, H3.X and H3.Y.	H3Y1 H3Y2	1.43e-05	2	132	2	20819935
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	CAND1 MYCBP2 UGGT1 COQ8B OBSL1 PPP6R1 IPO4 THEM6 MDN1 NUP210 LRRC41	2.12e-05	606	132	11	36538041
Pubmed	The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.	DSG1 DHX37 SAMHD1 IPO4 ECT2 MDN1 SACS EIF4G2 CCAR2	2.35e-05	400	132	9	35013556
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	DSG1 DHX37 UGGT1 ZNF185 EVPL IPO4 DDX55 ECT2 IKBIP GTF2I DST PRPF4 PKP3 IMP4 NUP210 PUM3	2.37e-05	1257	132	16	36526897
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	DENND4A CAND1 DSG1 DHX37 UGGT1 MISP3 SAMHD1 IPO4 DDX55 GTF2I MDN1 AP1G1 PRPF4 NUP210 EIF4G2 CCAR2 PUM3	2.94e-05	1425	132	17	30948266
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	CAND1 SAMHD1 IPO4 GTF2I MDN1 AP1G1 PRPF4 NUP210 TUBGCP3 EIF4G2 CCAR2	3.39e-05	638	132	11	33239621
Pubmed	Defining the membrane proteome of NK cells.	MYO1G CAND1 MYCBP2 CEP290 IPO4 DDX55 IKBIP GTF2I MDN1 AP1G1 NUP210 TUBGCP3 EIF4G2 TAP2 LRRC41	3.92e-05	1168	132	15	19946888
Pubmed	Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	CAND1 MYCBP2 MCF2L2 FRYL NUP210	4.12e-05	100	132	5	10048485
Pubmed	Association of GTF2I, NFKB1, and TYK2 Regional Polymorphisms With Systemic Sclerosis in a Chinese Han Population.	TYK2 GTF2I	4.28e-05	3	132	2	34248934
Pubmed	Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome.	ORC1 CDT1	4.28e-05	3	132	2	21358631
Pubmed	HIV/simian immunodeficiency virus (SIV) accessory virulence factor Vpx loads the host cell restriction factor SAMHD1 onto the E3 ubiquitin ligase complex CRL4DCAF1.	DCAF1 SAMHD1	4.28e-05	3	132	2	22362772
Pubmed	SPR-Based study of affinity of cytochrome P450s / redox partners interactions modulated by steroidal substrates.	CYP17A1 CYP21A2	4.28e-05	3	132	2	30468857
Pubmed	Inhibition of Vpx-Mediated SAMHD1 and Vpr-Mediated Host Helicase Transcription Factor Degradation by Selective Disruption of Viral CRL4 (DCAF1) E3 Ubiquitin Ligase Assembly.	DCAF1 SAMHD1	4.28e-05	3	132	2	28202763
Pubmed	RBX1 (RING box protein 1) E3 ubiquitin ligase is required for genomic integrity by modulating DNA replication licensing proteins.	ORC1 CDT1	4.28e-05	3	132	2	21115485
Pubmed	Identification of Lmo1 as part of a Hox-dependent regulatory network for hindbrain patterning.	HOXA2 HOXB2	4.28e-05	3	132	2	17676642
Pubmed	Structural basis of lentiviral subversion of a cellular protein degradation pathway.	DCAF1 SAMHD1	4.28e-05	3	132	2	24336198
Pubmed	Meier-Gorlin syndrome genotype-phenotype studies: 35 individuals with pre-replication complex gene mutations and 10 without molecular diagnosis.	ORC1 CDT1	4.28e-05	3	132	2	22333897
Pubmed	Stabilization of SAMHD1 by NONO is crucial for Ara-C resistance in AML.	DCAF1 SAMHD1	4.28e-05	3	132	2	35803902
Pubmed	Functional polymorphisms in the CYP3A4, CYP3A5, and CYP21A2 genes in the risk for hypertension in pregnancy.	CYP3A5 CYP21A2	4.28e-05	3	132	2	20617557
Pubmed	Chromatin remodeling factor CECR2 forms tissue-specific complexes with CCAR2 and LUZP1.	CECR2 CCAR2	4.28e-05	3	132	2	34197713
Pubmed	DUX4-Induced Histone Variants H3.X and H3.Y Mark DUX4 Target Genes for Expression.	H3Y1 H3Y2	4.28e-05	3	132	2	31722199
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	DCAF1 DENND4A MYCBP2 CEP290 OBSL1 IPO4 ECT2 IKBIP THEM6 GTF2I PRPF4 CCAR2 TMEM102 MAST3 INVS CHST3	4.30e-05	1321	132	16	27173435
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	MYCBP2 VPS39 DDX55 TRRAP GTF2I IMP4 NUP210 PUM3 ZBTB11	4.93e-05	440	132	9	34244565
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	CAND1 CECR2 CEP290 OBSL1 TRRAP IKBIP NUP210 CCAR2 CDT1	8.02e-05	469	132	9	27634302
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MYCBP2 VPS39 TMEM94 FRYL PPP6R1 TRRAP ABCA7 RYR1 TYK2 ORC1 DST MDN1 MROH6 TNFAIP2	8.31e-05	1105	132	14	35748872
Pubmed	Cardiac defects and altered ryanodine receptor function in mice lacking FKBP12.	RYR1 SNTA1	8.54e-05	4	132	2	9461216
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	DCAF1 CECR2 COQ8B OBSL1 PPP6R1 TRRAP ZC3H3 ABCA7 SLC4A1 TYK2 PRPF4 TUBGCP3 AGBL1 LRRC41	9.22e-05	1116	132	14	31753913
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	DHX37 EVPL DDX55 TRRAP THEM6 GTF2I MDN1 PRPF4 IMP4 NUP210 TUBGCP3 PUM3	9.75e-05	847	132	12	35850772
Pubmed	The TIP60 Complex Is a Conserved Coactivator of HIF1A.	SAMHD1 TRRAP GTF2I NUP210 CCAR2	9.81e-05	120	132	5	27320910
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	DCAF1 DSG1 DHX37 IPO4 ECT2 ORC1 GTF2I MDN1 IMP4 PWWP3A CCAR2 PUM3 ZBTB11	1.05e-04	989	132	13	36424410
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	DCAF1 VPS33A PPP6R1 IPO4 MDN1 PRPF4 CCAR2	1.06e-04	282	132	7	23667531
Pubmed	TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN.	DSG1 MYCBP2 ULK3 GTF2I CEP250 HOOK2 CCDC180 AGBL1	1.11e-04	382	132	8	37249651
Pubmed	Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.	DCAF1 CAND1 MYCBP2 VPS39 UGGT1 CEP250 PUM3	1.14e-04	285	132	7	32838362
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ZNF821 RELN CAND1 MYCBP2 VPS39 CEP290 MCF2L2 OBSL1 P4HTM DST SACS EIF4G2 MERTK ZBTB11 SNTA1	1.14e-04	1285	132	15	35914814
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	CAND1 UGGT1 COQ8B SAMHD1 PPP6R1 IPO4 THEM6 GTF2I DST MDN1 NUP210 EIF4G2 CCAR2 PUM3 HOOK2 TAP2	1.18e-04	1440	132	16	30833792
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	CEP290 COQ8B EVPL SAMHD1 PPP6R1 ECT2 RYR1 DST MDN1 RDH16 ZBTB11	1.21e-04	736	132	11	29676528
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	CAND1 VPS39 FRYL PPP6R1 MDN1	1.38e-04	129	132	5	23022380
Pubmed	ALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQ.	DSG1 MYCBP2 SAMHD1 IPO4 GTF2I MDN1 PRPF4 EIF4G2 CCAR2 CDT1	1.42e-04	624	132	10	33729478
Pubmed	Gene expression profiling of preplate neurons destined for the subplate: genes involved in transcription, axon extension, neurotransmitter regulation, steroid hormone signaling, and neuronal survival.	RELN RYR1	1.42e-04	5	132	2	19398467
Pubmed	Mutations in the pre-replication complex cause Meier-Gorlin syndrome.	ORC1 CDT1	1.42e-04	5	132	2	21358632
Pubmed	Cyclin L2 is a critical HIV dependency factor in macrophages that controls SAMHD1 abundance.	DCAF1 SAMHD1	1.42e-04	5	132	2	25532805
Pubmed	Induced chromosome deletions cause hypersociability and other features of Williams-Beuren syndrome in mice.	GTF2I TRIM50	1.42e-04	5	132	2	20049703
Pubmed	HIV-2 and SIVmac accessory virulence factor Vpx down-regulates SAMHD1 enzyme catalysis prior to proteasome-dependent degradation.	DCAF1 SAMHD1	1.42e-04	5	132	2	23677995
Pubmed	The CYP3A4*1B variant is related to the onset of puberty, a known risk factor for the development of breast cancer.	CYP3A5 CYP17A1	1.42e-04	5	132	2	12692107
Pubmed	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.	MYCBP2 VPS39 COQ8B MDN1 CEP250 NUP210 TUBGCP3	1.49e-04	298	132	7	32353859
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	REC8 CAND1 ZSWIM3 CYP3A5 VPS39 ICE2 SLC34A3 DDX55 TRRAP GTF2I IMP4 PUM3 SSH2 LRRC41 CAPN15	1.62e-04	1327	132	15	32694731
Pubmed	A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.	OBSL1 ULK3 PRPF4 EIF4G2 CCAR2 VPS37D CAPN15	1.62e-04	302	132	7	30561431
Pubmed	DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases.	DCAF1 CAND1 CDT1	1.63e-04	28	132	3	17079684
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	MYCBP2 DHX37 VPS33A TRRAP DST LRRC41	1.65e-04	212	132	6	33853758
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	DCAF1 DSG1 UGGT1 CEP290 OBSL1 GTF2I PRPF4 CEP250 TUBGCP3 HOOK2	1.71e-04	639	132	10	23443559
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CAND1 MYCBP2 FRYL ZSWIM1 TRRAP TYK2 PARP10 GTF2I NACC2 PKP3 NUP210 ZFHX2 HOOK2 MME LRRC41 INVS	1.72e-04	1489	132	16	28611215
Pubmed	Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.	MYCBP2 TRRAP MDN1 SACS	2.06e-04	76	132	4	27542412
Pubmed	Localization of antigens associated with adherens junctions, desmosomes, and hemidesmosomes during murine molar morphogenesis.	DSG1 DST	2.12e-04	6	132	2	9615388
Pubmed	Expression of Cyp21a1 and Cyp11b1 in the fetal mouse testis.	CYP17A1 CYP21A2	2.12e-04	6	132	2	17890294
Pubmed	Degree of predicted minor histocompatibility antigen mismatch correlates with poorer clinical outcomes in nonmyeloablative allogeneic hematopoietic cell transplantation.	MYO1G PUM3	2.12e-04	6	132	2	20353833
Pubmed	A homeotic transformation is generated in the rostral branchial region of the head by disruption of Hoxa-2, which acts as a selector gene.	HOXA2 HOXB2	2.12e-04	6	132	2	7903601
Pubmed	HIV: Ringside views.	DCAF1 SAMHD1	2.12e-04	6	132	2	24402277
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	VPS39 VPS33A FRYL GTF2I USP35	2.53e-04	147	132	5	29576527
Pubmed	Proteomic profiling of the human cytomegalovirus UL35 gene products reveals a role for UL35 in the DNA repair response.	DCAF1 IPO4	2.97e-04	7	132	2	22072767
Pubmed	Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve.	HOXA2 HOXB2	2.97e-04	7	132	2	8898234
Pubmed	Hoxa1 and Krox-20 synergize to control the development of rhombomere 3.	HOXA2 HOXB2	2.97e-04	7	132	2	9806922
Pubmed	Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1 and colorectal cancer risk.	CYP3A5 CYP17A1	2.97e-04	7	132	2	17615053
Pubmed	Novel effects of chromosome Y on cardiac regulation, chromatin remodeling, and neonatal programming in male mice.	CYP17A1 KDM5D	2.97e-04	7	132	2	24105479
Pubmed	Analysis of mRNA expression for steroidogenic enzymes in the remaining adrenal cortices attached to adrenocortical adenomas.	CYP17A1 CYP21A2	2.97e-04	7	132	2	18505908
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	CAND1 DSG1 MYCBP2 DHX37 UGGT1 VPS33A SAMHD1 IPO4 ECT2 GTF2I MDN1 NUP210 CCAR2 LRRC41	3.13e-04	1257	132	14	37317656
Pubmed	Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.	MYO1G SAMHD1 TAOK3 MDN1 CEP250 NUP210 PUM3	3.33e-04	340	132	7	29478914
Pubmed	SPE-39 family proteins interact with the HOPS complex and function in lysosomal delivery.	VPS39 VPS33A	3.94e-04	8	132	2	19109425
Pubmed	Cell-matrix interactions and cell-cell junctions during epithelial histo-morphogenesis in the developing mouse incisor.	DSG1 DST	3.94e-04	8	132	2	11669375
Pubmed	Identification of a novel population of adrenal-like cells in the mammalian testis.	CYP17A1 CYP21A2	3.94e-04	8	132	2	16949566
Pubmed	A Conserved Role for Girdin in Basal Body Positioning and Ciliogenesis.	CEP290 CEP250	3.94e-04	8	132	2	27623382
Pubmed	Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes.	VPS39 VPS33A	3.94e-04	8	132	2	25783203
Pubmed	Structural basis of Vps33A recruitment to the human HOPS complex by Vps16.	VPS39 VPS33A	3.94e-04	8	132	2	23901104
Pubmed	Roles of Hoxa1 and Hoxa2 in patterning the early hindbrain of the mouse.	HOXA2 HOXB2	3.94e-04	8	132	2	10662633
Pubmed	Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains.	IPO4 IMP4	3.94e-04	8	132	2	11823430
Pubmed	The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17.	VPS39 VPS33A	3.94e-04	8	132	2	24554770
Pubmed	A WD-repeat protein stabilizes ORC binding to chromatin.	ORC1 CDT1	3.94e-04	8	132	2	20932478
Interaction	LGALS3BP interactions	CAND1 MYCBP2 UGGT1 CEP290 OBSL1 SAMHD1 ZC3H3 TYK2 PRPF4 CEP250 TUBGCP3	1.86e-06	286	126	11	int:LGALS3BP
Interaction	EMG1 interactions	ICE2 CEP290 OBSL1 IPO4 ECT2 TRRAP EIF4G2	7.04e-06	113	126	7	int:EMG1
Interaction	LTB4R2 interactions	TMEM94 OBSL1 GPR146 P4HTM IMP4	1.35e-05	49	126	5	int:LTB4R2
GeneFamily	EF-hand domain containing\|Plakins	EVPL DST	6.29e-04	8	87	2	939
GeneFamily	Zinc fingers SWIM-type\|Mitogen-activated protein kinase kinase kinases	ZSWIM3 ZSWIM1	8.06e-04	9	87	2	90
CoexpressionAtlas	PP_MEG_top-relative-expression-ranked_2500_k-means-cluster#2	DENND4A CYP17A1 PPM1M CMPK2 ABCA7 STPG3 GPR146 ULK3 PARP10 TAOK3 ACSM3 C16orf86 NUP210 TMEM102 ZBTB11 TAP2	1.44e-05	769	127	16	PP_MEG_2500_K2
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN MYCBP2 UGGT1 FRYL KDM5D ZC3H3 DST	1.92e-06	195	132	7	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN MYCBP2 UGGT1 FRYL KDM5D ZC3H3 DST	1.92e-06	195	132	7	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	Control-Epithelial_alveolar-AT_2-Differentiating_AT1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BRINP3 CECR2 PRSS22 SLC4A1 ZFHX2 SLC30A10	7.48e-06	157	132	6	4766f7d545bf2d775390589460677519cb92f4d5
ToppCell	droplet-Lung-immune-endo-depleted-3m-Lymphocytic-Zbtb32+_B\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VPS39 DHX37 CECR2 ECT2 MDN1 TUBGCP3	8.63e-06	161	132	6	249c2b97cc25de5053f5048ee354615df49b2081
ToppCell	droplet-Heart-nan-24m-Hematologic-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1G B4GALNT1 RYR1 SLC4A1 PKP3 NUP210	8.63e-06	161	132	6	7e60001637ef0f6fc67ef8a36ab80ebb25b0b0ab
ToppCell	facs-Marrow-T_cells-18m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALNT16 ACSM3 C16orf86 TRIM50 SLC30A10 CHST3	8.94e-06	162	132	6	22f1abd20f43bc7e7fc46969da9962faf70ae5d2
ToppCell	facs-Marrow-T_cells-18m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALNT16 ACSM3 C16orf86 TRIM50 SLC30A10 CHST3	8.94e-06	162	132	6	966df4558140c3d541999ab553f201ae76a1c401
ToppCell	Calu_3-infected\|Calu_3 / Cell line, Condition and Strain	CMPK2 SAMHD1 PARP10 DST TNFAIP2 TAP2	1.79e-05	183	132	6	8f7f5000645f24f20a8d7700c4df1f8953a1780b
Disease	Disorder of endocrine system	CYP17A1 CYP21A2	1.79e-04	5	126	2	cv:C0014130
Disease	Congenital adrenal hyperplasia	CYP17A1 CYP21A2	1.79e-04	5	126	2	cv:C0001627
Disease	congenital adrenal hyperplasia (is_implicated_in)	CYP17A1 CYP21A2	2.68e-04	6	126	2	DOID:0050811 (is_implicated_in)
Disease	EAR, PATELLA, SHORT STATURE SYNDROME	ORC1 CDT1	3.75e-04	7	126	2	C1868684
Disease	Congenital adrenal hyperplasia	CYP17A1 CYP21A2	6.39e-04	9	126	2	C0001627
Disease	ciliopathy (implicated_via_orthology)	CEP290 TOGARAM2 INVS	6.69e-04	40	126	3	DOID:0060340 (implicated_via_orthology)
Disease	Congenital small ears	HOXA2 ORC1 CDT1	7.20e-04	41	126	3	C0152423
Disease	Paranoia	ICE2 TYK2	9.70e-04	11	126	2	C1456784
Disease	peanut allergy measurement, parental genotype effect measurement	RYR1 PWWP3A	9.70e-04	11	126	2	EFO_0005939, EFO_0007017
Disease	Renal dysplasia and retinal aplasia (disorder)	CEP290 INVS	1.16e-03	12	126	2	C0403553
Disease	Thrombosis	CYP3A5 ADAMTS13 MERTK	1.21e-03	49	126	3	C0040053
Disease	lymphocyte measurement	MYO1G ABCA7 NUP210 CDT1	1.62e-03	117	126	4	EFO_0803546
Disease	Opioid use measurement	NLRP7 MYOM2	1.83e-03	15	126	2	EFO_0009937
Disease	obsolete_red blood cell distribution width	CYP21A2 PSMB11 SAMHD1 ECT2 ABCA7 SLC4A1 PARP10 TAOK3 GTF2I NUP210 CDT1 HOOK2 SLC30A10 MAST3	1.87e-03	1347	126	14	EFO_0005192
Disease	Sjogren syndrome	RELN GTF2I NACC2	2.18e-03	60	126	3	EFO_0000699
Disease	rheumatoid arthritis, COVID-19	FRYL TYK2 TAP2	2.62e-03	64	126	3	EFO_0000685, MONDO_0100096
Disease	Chronic myeloproliferative disorder	ORC1 CDT1	2.95e-03	19	126	2	C1292778
Disease	hippuric acid measurement	FRMD1 KIF25	2.95e-03	19	126	2	EFO_0010496
Disease	venous thromboembolism	RELN MCF2L2 TOGARAM2 ADAMTS13 ZC3H3 FRMD1 AGBL1	3.68e-03	460	126	7	EFO_0004286
Disease	Seckel syndrome	ORC1 CDT1	3.95e-03	22	126	2	C0265202
Disease	Leber Congenital Amaurosis	CEP290 MERTK	3.95e-03	22	126	2	C0339527

Protein segments in the cluster

Peptide	Gene	Start	Entry
ELRRRLTPLQLEIQR	CCAR2	891	Q8N163
IRLLGRRPTLQQITE	BRINP3	111	Q76B58
APLETLRLERKAQRL	C16orf86	176	Q6ZW13
ALLSLVPVQRELLRR	SLC4A1	331	P02730
RLERLVDVLERTPLD	B4GALNT1	366	Q00973
NETLRLFPVAIRLER	CYP3A5	361	P20815
LLLRKLPFQRLVREI	H3Y2	61	P0DPK5
TQRSLRAELELPAIR	FCRL4	336	Q96PJ5
LERLPELARVLRSVF	CDT1	451	Q9H211
ELRIQIRRFEELLPQ	CCDC180	1441	Q9P1Z9
QDLPLRTRVEILHRL	CECR2	106	Q9BXF3
ALTEDRLPRLEEIRI	ADAMTS13	631	Q76LX8
ALRSLVELRALLQRP	ABCA7	196	Q8IZY2
RIRIFEDIRRLIQPS	AGBL1	556	Q96MI9
RSEQLREDRTIPLIV	GALNT16	46	Q8N428
RVLRLTRLSPEIVEL	P4HTM	296	Q9NXG6
IFLPFLNIEIRDLRR	DENND4A	1486	Q7Z401
RELPEVSRRELDLLI	REC8	211	O95072
RQSLVELLIRPVQRL	ECT2	586	Q9H8V3
RLRRALEENRLIPTE	IMP4	31	Q96G21
LLVILVTVLQRRRPA	SLC34A3	526	Q8N130
EVRRRELLESISPAL	PUM3	476	Q15397
ILDVRDVQGTRLLRL	CAPN15	721	O75808
SDPFLQVRILRLLRI	AP1G1	241	O43747
RPRQLRVLRPLEDVT	OBSL1	1536	O75147
RPAEVRLLILENILL	NUP210	231	Q8TEM1
QVEVLLLRAVRIRAP	NUP210	1161	Q8TEM1
LILRAVFRLPSQDVR	OR52E4	221	Q8NGH9
LVAIVLRRLRELQLQ	DCAF1	171	Q9Y4B6
INELDLQVGRVRLLR	MDN1	621	Q9NU22
VSRLRNLRPDDVFII	MGAT3	301	Q09327
RLQLEKLLESLPDVR	MERTK	851	Q12866
LERIVERLRQPPSIS	DST	6061	Q03001
EILPAELRETLLRLQ	HOOK2	451	Q96ED9
RSRRPRLETILALLV	KDM5D	1236	Q9BY66
RLERSIQFSERVLPI	PRSS22	146	Q9GZN4
LAFVIPILEILLRRE	DDX55	61	Q8NHQ9
SAVLQRLDRLVEPLR	CAND1	1136	Q86VP6
RLPLLNATIAEVLRL	CYP21A2	341	P08686
EPLARLELFVVLTRL	CYP21A2	431	P08686
DLSPRRRIIRDLLET	MCF2L2	616	Q86YR7
AFRKLPQLRELVLRD	EPYC	186	Q99645
LLLRKLPFQRLVREI	H3Y1	61	P0DPK2
EIRFLINPELIISRL	PARG	756	Q86W56
RQILSRPERLLFILD	NLRP1	396	Q9C000
QLLQLRTQRPLERLE	EVPL	941	Q92817
RDILRVQLVRIFELL	FRYL	976	O94915
ERLARILLQEIPIRS	FBXO39	296	Q8N4B4
SVARLIRQEERLPID	MME	251	P08473
EILRRLDVRLLEVSP	TUBGCP3	616	Q96CW5
RPTARLLREEVILER	MROH6	391	A6NGR9
ELRLRELREGQLPSV	PSMB11	111	A5LHX3
ERFPEQRQVLILLLL	PCDHB15	6	Q9Y5E8
PARIRFLLQDTVELR	EIF4G2	291	P78344
DLERPLELRVRVLDI	DSG1	136	Q02413
LTLRIGRLVTDLLQR	IKBIP	301	Q70UQ0
REARTVPLDTRNIRL	RELN	1491	P78509
PRRVEIAALLDLTER	HOXB2	171	P14652
LLLVEPSRNDLLLRV	ORC1	831	Q13415
VLVLLPSREQLRLAV	FRMD1	56	Q8N878
LILLLTVSPEERLQR	CMPK2	371	Q5EBM0
LLLVRCSVQRIETRP	ICE2	741	Q659A1
LSRDKVINELRLRLP	CEP290	1496	O15078
VINELRLRLPATAER	CEP290	1501	O15078
LLLEATIREVLRLRP	CYP17A1	351	P05093
LPEVAARLAIERINR	GUCY2F	71	P51841
LDSLEPRLQRELERL	CEP250	2141	Q9BV73
ETARRIQDLIPVLLR	COQ8B	461	Q96D53
QDLITRLLRQSPLDR	MAST3	611	O60307
RPLKDRINLVLSREL	DHFR2	66	Q86XF0
EVERLLPTRQRVSLF	CASP10	101	Q92851
AEALRLLRPEQVLKR	EME2	61	A4GXA9
ALVLLSRVRREDTPL	GPR146	206	Q96CH1
IPRLERILLAKERIR	GTF2I	416	P78347
ARLQPRTESLLRALV	DHX37	1096	Q8IY37
ELIRLRIPSLVILDD	SACS	816	Q9NZJ4
LRIRAILRSLVPLED	RYR1	2451	P21817
LEQLLRELLLPDTER	IPO4	6	Q8TEX9
RELLLPDTERIRRAT	IPO4	11	Q8TEX9
RLLQRCERRPVEQVL	PARP10	871	Q53GL7
IDLLPVELRLQIIQR	INVS	891	Q9Y283
PRRVEIAALLDLTER	HOXA2	171	O43364
RIRFILDVLLPEAII	PWWP3A	651	Q2TAK8
QLPEALLLQRRRVTV	SNTA1	76	Q13424
REALRQIPLERIIVE	TATDN2	691	Q93075
LLQPRVRDLLAEQRF	THEM6	36	Q8WUY1
ETIRDPVQLLRGILR	TCP11X1	181	B4DZS4
ETIRDPVQLLRGILR	TCP11X2	86	Q5H9J9
RLELCDPTQRLRVAL	SLC22A17	176	Q8WUG5
LLVRIIDTPQFQRLR	SAMHD1	131	Q9Y3Z3
LLRRLEEPRTGQELT	TOGARAM2	371	Q6ZUX3
ILELTRAIVRALPLL	LRRC41	536	Q15345
RAIVRALPLLRVLSI	LRRC41	541	Q15345
VIDVTLSLLPLVRRA	RDH16	141	O75452
PAERRERLRNILSVV	PRPF4	126	O43172
RVDVRLPRQDALVLE	RNF215	61	Q9Y6U7
RELDISQLLLRPVIV	RNF215	166	Q9Y6U7
FVRRDRPLRVLIDLI	TAOK3	276	Q9H2K8
AIARALVRDPRVLIL	TAP2	616	Q03519
ALLVTTRPRALRDLQ	NLRP7	296	Q8WX94
LVIVVLPVRNSLRRE	MYCBP2	1666	O75592
IIPRVAEELFRLILE	KIF25	96	Q9UIL4
RVRLLRELSERLELV	SVEP1	71	Q4LDE5
SLQRGDRVILILPRV	ACSM3	116	Q53FZ2
RLDLRVIQLVRDPRA	CHST3	291	Q7LGC8
LEQERILNPLLDRVR	PKP3	651	Q9Y446
LPRQNRLRIEIEEAL	TCP11	126	Q8WWU5
IFVEAVLRLARPERI	SLC30A10	96	Q6XR72
LLRDQVLGVLRRPLE	TNFAIP2	131	Q03169
ILRRQIRLLQGLIDD	ZC3H3	6	Q8IXZ2
ELEVVLQPERRRDLI	ZBTB11	61	O95625
LLREPVHVEVRLLQR	ZP1	431	P60852
RDKRLRTTILPEQLE	ZFHX2	1856	Q9C0A1
GRELVELRVRPVLNL	MISP3	31	Q96FF7
FILLRPEDNIRLAVR	SSH2	81	Q76I76
RLFRVLETPVIDNIR	TMEM94	241	Q12767
ELVLIPLRQRLEERQ	SPEF1	101	Q9Y4P9
IQRFLPRELQIVRTL	TSSK3	51	Q96PN8
LRELLLEQRPLITAD	STPG3	86	Q8N7X2
SRAILVRRDEIRPLS	PPM1M	236	Q96MI6
LVRRVLEAARQPLER	USP35	21	Q9P2H5
RRLLLFDLIPVVSVA	TMEM102	311	Q8N9M5
LQDEPKLDRIVRLSR	VPS37D	31	Q86XT2
LLRLLTCVERPQLRQ	PPP6R1	166	Q9UPN7
RAILQEIFPAARILL	ZSWIM3	291	Q96MP5
PLEVRLQRLERERTA	ZNF821	266	O75541
ILFVPRRSLLCEQRL	VPS33A	111	Q96AX1
LERPVERLLLTSLQS	ZSWIM1	186	Q9BR11
LPNVSLARVIEALRL	TRIM50	66	Q86XT4
REERVLQLLRLLNPC	TRRAP	3541	Q9Y4A5
EIVRLQILTPRAGLR	ZNF185	281	O15231
VTREAQRLAPLLLVL	UGGT1	996	Q9NYU2
LLQRLLERDPSRRIS	ULK3	246	Q6PHR2
VLRLTELLERGERLP	TYK2	1121	P29597
EPRLLVQSIELQRPR	VPS39	271	Q96JC1
TLEQSRARLIPIIVL	MYO1G	701	B0I1T2
VLIRRDLVALPASLI	NACC2	311	Q96BF6
FEERISRAPEILVRL	MYOM2	146	P54296