Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontransmembrane transporter binding

AKAP6 STX1A CTNNB1 SLC5A3

2.01e-04172344GO:0044325
GeneOntologyBiologicalProcessregulation of nucleus organization

NFE2L1 SYNE1

2.48e-062332GO:1903353
GeneOntologyBiologicalProcesscellular response to organic cyclic compound

AKAP6 SAFB2 PRKD1 TAF1 CTNNB1 DTNBP1 NFE2L1 RYR2

3.80e-06605338GO:0071407
GeneOntologyBiologicalProcessprotein polyubiquitination

DCAF15 TAF1 CTNNB1 SASH1 NFE2L1 CDC16

5.79e-06289336GO:0000209
GeneOntologyBiologicalProcessendomembrane system organization

PRKD1 EMC7 STX1A DTNBP1 CHMP2A SYNE1 NBEAL2 CHMP2B

8.21e-06672338GO:0010256
GeneOntologyBiologicalProcessregulation of protein autoubiquitination

TAF1 SASH1

3.71e-056332GO:1902498
GeneOntologyBiologicalProcessprotein modification by small protein conjugation

DCAF15 STX1A TAF1 CTNNB1 SASH1 NFE2L1 KLHL18 CDC16

6.32e-05893338GO:0032446
GeneOntologyBiologicalProcessESCRT III complex disassembly

CHMP2A CHMP2B

1.11e-0410332GO:1904903
GeneOntologyBiologicalProcessESCRT complex disassembly

CHMP2A CHMP2B

1.11e-0410332GO:1904896
GeneOntologyBiologicalProcessregulation of odontoblast differentiation

CTNNB1 NFE2L1

1.35e-0411332GO:1901329
GeneOntologyBiologicalProcessprotein modification by small protein conjugation or removal

DCAF15 STX1A TAF1 CTNNB1 SASH1 NFE2L1 KLHL18 CDC16

1.48e-041009338GO:0070647
GeneOntologyBiologicalProcessnucleus organization

CHMP2A NFE2L1 SYNE1 CHMP2B

1.51e-04170334GO:0006997
GeneOntologyBiologicalProcessvesicle fusion with vacuole

CHMP2A CHMP2B

1.91e-0413332GO:0051469
GeneOntologyBiologicalProcessmultivesicular body-lysosome fusion

CHMP2A CHMP2B

1.91e-0413332GO:0061763
GeneOntologyBiologicalProcessresponse to organic cyclic compound

AKAP6 SAFB2 PRKD1 TAF1 CTNNB1 DTNBP1 NFE2L1 RYR2

1.93e-041048338GO:0014070
GeneOntologyBiologicalProcessvacuole fusion

CHMP2A CHMP2B

2.23e-0414332GO:0097576
GeneOntologyBiologicalProcessviral budding from plasma membrane

CHMP2A CHMP2B

2.23e-0414332GO:0046761
GeneOntologyBiologicalProcesscellular response to epinephrine stimulus

AKAP6 RYR2

2.23e-0414332GO:0071872
GeneOntologyBiologicalProcesspost-translational protein modification

DCAF15 STX1A TAF1 CTNNB1 SASH1 NFE2L1 KLHL18 CDC16

2.28e-041074338GO:0043687
GeneOntologyBiologicalProcesspositive regulation of transport

AKAP6 NADK PRKD1 STX1A DTNBP1 CHMP2A SYNE1 RYR2

2.38e-041081338GO:0051050
GeneOntologyBiologicalProcessprotein ubiquitination

DCAF15 TAF1 CTNNB1 SASH1 NFE2L1 KLHL18 CDC16

2.47e-04811337GO:0016567
GeneOntologyBiologicalProcessnon-lytic viral release

CHMP2A CHMP2B

2.57e-0415332GO:0046753
GeneOntologyBiologicalProcessregulation of cell cycle process

TAF1 CTNNB1 CHMP2A NFE2L1 KLHL18 CDC16 CHMP2B

3.17e-04845337GO:0010564
GeneOntologyBiologicalProcessresponse to epinephrine

AKAP6 RYR2

3.33e-0417332GO:0071871
GeneOntologyBiologicalProcesslysosomal membrane organization

CHMP2A CHMP2B

3.74e-0418332GO:0097212
GeneOntologyBiologicalProcessendosome to lysosome transport via multivesicular body sorting pathway

CHMP2A CHMP2B

4.17e-0419332GO:0032510
GeneOntologyBiologicalProcessglial cell fate commitment

CTNNB1 NFE2L1

4.17e-0419332GO:0021781
GeneOntologyBiologicalProcessmidbody abscission

CHMP2A CHMP2B

4.17e-0419332GO:0061952
GeneOntologyBiologicalProcessodontoblast differentiation

CTNNB1 NFE2L1

4.17e-0419332GO:0071895
GeneOntologyBiologicalProcesspositive regulation of secretion by cell

NADK PRKD1 STX1A DTNBP1 CHMP2A

4.25e-04404335GO:1903532
GeneOntologyBiologicalProcessvesicle organization

STX1A DTNBP1 CHMP2A NBEAL2 CHMP2B

4.80e-04415335GO:0016050
GeneOntologyBiologicalProcessregulation of release of sequestered calcium ion into cytosol

AKAP6 PRKD1 RYR2

5.12e-0498333GO:0051279
GeneOntologyBiologicalProcesspositive regulation of secretion

NADK PRKD1 STX1A DTNBP1 CHMP2A

5.95e-04435335GO:0051047
GeneOntologyBiologicalProcesslate endosome to lysosome transport

CHMP2A CHMP2B

6.15e-0423332GO:1902774
GeneOntologyBiologicalProcessviral budding via host ESCRT complex

CHMP2A CHMP2B

6.15e-0423332GO:0039702
GeneOntologyBiologicalProcessregulation of mitotic spindle assembly

CHMP2A CHMP2B

6.70e-0424332GO:1901673
GeneOntologyBiologicalProcesspositive regulation of neurotransmitter secretion

STX1A DTNBP1

7.28e-0425332GO:0001956
GeneOntologyBiologicalProcessregulation of striated muscle contraction

AKAP6 PRKD1 RYR2

7.36e-04111333GO:0006942
GeneOntologyBiologicalProcessmaintenance of location in cell

AKAP6 PRKD1 SYNE1 RYR2

7.46e-04259334GO:0051651
GeneOntologyBiologicalProcessorganelle localization

STX1A CTNNB1 DTNBP1 CHMP2A SYNE1 CHMP2B

7.74e-04703336GO:0051640
GeneOntologyBiologicalProcessviral budding

CHMP2A CHMP2B

7.88e-0426332GO:0046755
GeneOntologyBiologicalProcessnuclear membrane reassembly

CHMP2A CHMP2B

7.88e-0426332GO:0031468
GeneOntologyBiologicalProcessresponse to muscle stretch

CTNNB1 RYR2

9.14e-0428332GO:0035994
GeneOntologyBiologicalProcessregulation of organelle assembly

EVI5 CHMP2A SYNE1 CHMP2B

9.98e-04280334GO:1902115
GeneOntologyBiologicalProcessregulation of organelle organization

EVI5 PRKD1 CTNNB1 CHMP2A NFE2L1 SYNE1 CDC16 CHMP2B

1.01e-031342338GO:0033043
GeneOntologyBiologicalProcessviral release from host cell

CHMP2A CHMP2B

1.05e-0330332GO:0019076
GeneOntologyBiologicalProcessexit from host cell

CHMP2A CHMP2B

1.05e-0330332GO:0035891
GeneOntologyBiologicalProcesscellular response to nitrogen compound

AKAP6 PRKD1 TAF1 CTNNB1 DTNBP1 RYR2

1.10e-03752336GO:1901699
GeneOntologyBiologicalProcesscellular response to alcohol

PRKD1 CTNNB1 NFE2L1

1.16e-03130333GO:0097306
GeneOntologyBiologicalProcesspositive regulation of neurotransmitter transport

STX1A DTNBP1

1.19e-0332332GO:0051590
GeneOntologyBiologicalProcessmitotic cytokinetic process

CHMP2A CHMP2B

1.27e-0333332GO:1902410
GeneOntologyBiologicalProcessmultivesicular body assembly

CHMP2A CHMP2B

1.27e-0333332GO:0036258
GeneOntologyBiologicalProcessregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

AKAP6 RYR2

1.27e-0333332GO:0010880
GeneOntologyBiologicalProcessplasma membrane repair

CHMP2A CHMP2B

1.35e-0334332GO:0001778
GeneOntologyBiologicalProcessmultivesicular body organization

CHMP2A CHMP2B

1.35e-0334332GO:0036257
GeneOntologyBiologicalProcessregulation of spindle assembly

CHMP2A CHMP2B

1.35e-0334332GO:0090169
GeneOntologyBiologicalProcessvirion assembly

CHMP2A CHMP2B

1.43e-0335332GO:0019068
GeneOntologyBiologicalProcessvesicle fusion

STX1A CHMP2A CHMP2B

1.50e-03142333GO:0006906
GeneOntologyBiologicalProcesspositive regulation of mesenchymal cell proliferation

CTNNB1 SYNE1

1.51e-0336332GO:0002053
GeneOntologyBiologicalProcesspositive regulation of molecular function

AKAP6 EVI5 PRKD1 TAF1 CTNNB1 SASH1 RYR2 SLC5A3

1.52e-031430338GO:0044093
GeneOntologyBiologicalProcessmitotic nuclear division

CHMP2A NFE2L1 CDC16 CHMP2B

1.56e-03316334GO:0140014
GeneOntologyBiologicalProcessorganelle membrane fusion

STX1A CHMP2A CHMP2B

1.56e-03144333GO:0090174
GeneOntologyBiologicalProcessubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

CHMP2A CHMP2B

1.60e-0337332GO:0043162
GeneOntologyBiologicalProcessrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum

AKAP6 RYR2

1.60e-0337332GO:0014808
GeneOntologyBiologicalProcessrelease of sequestered calcium ion into cytosol

AKAP6 PRKD1 RYR2

1.62e-03146333GO:0051209
GeneOntologyBiologicalProcessproteolysis involved in protein catabolic process

TAF1 CTNNB1 CHMP2A NFE2L1 CDC16 CHMP2B

1.63e-03812336GO:0051603
GeneOntologyBiologicalProcessestablishment of organelle localization

CTNNB1 DTNBP1 CHMP2A SYNE1 CHMP2B

1.64e-03546335GO:0051656
GeneOntologyBiologicalProcessvesicle-mediated transport in synapse

STX1A CTNNB1 DTNBP1 SYNE1

1.65e-03321334GO:0099003
GeneOntologyBiologicalProcessnegative regulation of sequestering of calcium ion

AKAP6 PRKD1 RYR2

1.65e-03147333GO:0051283
GeneOntologyBiologicalProcesscellular response to oxygen-containing compound

AKAP6 NADK PRKD1 TAF1 CTNNB1 DTNBP1 SASH1 NFE2L1

1.66e-031450338GO:1901701
GeneOntologyBiologicalProcessregulation of calcium ion transport

AKAP6 PRKD1 CTNNB1 RYR2

1.69e-03323334GO:0051924
GeneOntologyBiologicalProcessregulation of sequestering of calcium ion

AKAP6 PRKD1 RYR2

1.72e-03149333GO:0051282
GeneOntologyBiologicalProcesscardiac muscle tissue development

AKAP6 CTNNB1 SYNE1 RYR2

1.77e-03327334GO:0048738
GeneOntologyBiologicalProcesslate endosome to vacuole transport

CHMP2A CHMP2B

1.77e-0339332GO:0045324
GeneOntologyBiologicalProcesspositive regulation of calcium ion transmembrane transporter activity

AKAP6 RYR2

1.77e-0339332GO:1901021
GeneOntologyBiologicalProcessrelease of sequestered calcium ion into cytosol by endoplasmic reticulum

AKAP6 RYR2

1.77e-0339332GO:1903514
GeneOntologyBiologicalProcesssequestering of calcium ion

AKAP6 PRKD1 RYR2

1.85e-03153333GO:0051208
GeneOntologyBiologicalProcessendosome transport via multivesicular body sorting pathway

CHMP2A CHMP2B

2.15e-0343332GO:0032509
GeneOntologyBiologicalProcessregulation of cardiac muscle cell contraction

AKAP6 RYR2

2.15e-0343332GO:0086004
GeneOntologyBiologicalProcessmuscle structure development

AKAP6 PRKD1 CTNNB1 DTNBP1 SYNE1 RYR2

2.15e-03858336GO:0061061
GeneOntologyBiologicalProcessstriated muscle tissue development

AKAP6 CTNNB1 SYNE1 RYR2

2.24e-03349334GO:0014706
GeneOntologyBiologicalProcessregulation of mitotic spindle organization

CHMP2A CHMP2B

2.25e-0344332GO:0060236
GeneOntologyBiologicalProcesssarcoplasmic reticulum calcium ion transport

AKAP6 RYR2

2.25e-0344332GO:0070296
GeneOntologyBiologicalProcesscentrosome cycle

CTNNB1 CHMP2A CHMP2B

2.26e-03164333GO:0007098
GeneOntologyBiologicalProcessresponse to purine-containing compound

AKAP6 TAF1 RYR2

2.34e-03166333GO:0014074
GeneOntologyBiologicalProcessregulation of mesenchymal cell proliferation

CTNNB1 SYNE1

2.35e-0345332GO:0010464
GeneOntologyBiologicalProcessregulation of cellular component biogenesis

EVI5 PRKD1 STX1A CTNNB1 CHMP2A SYNE1 CHMP2B

2.37e-031189337GO:0044087
GeneOntologyCellularComponentnuclear envelope

AKAP6 STX1A CTNNB1 CHMP2A SYNE1 RYR2 CHMP2B

1.79e-05560327GO:0005635
GeneOntologyCellularComponentmembrane protein complex

AKAP6 EMC7 STX1A EVC2 CTNNB1 CHMP2A SYNE1 RYR2 CHMP2B SLC5A3

5.19e-0514983210GO:0098796
GeneOntologyCellularComponentautophagosome membrane

PRKD1 CHMP2A CHMP2B

9.01e-0557323GO:0000421
GeneOntologyCellularComponentjunctional sarcoplasmic reticulum membrane

AKAP6 RYR2

1.01e-0410322GO:0014701
GeneOntologyCellularComponentamphisome membrane

CHMP2A CHMP2B

1.75e-0413322GO:1904930
GeneOntologyCellularComponentESCRT III complex

CHMP2A CHMP2B

2.04e-0414322GO:0000815
GeneOntologyCellularComponentamphisome

CHMP2A CHMP2B

2.35e-0415322GO:0044753
GeneOntologyCellularComponentsupramolecular fiber

PRKD1 KIF3C CTNNB1 CHMP2A SYNE1 RYR2 CHMP2B CEP57L1

3.12e-041179328GO:0099512
GeneOntologyCellularComponentsupramolecular polymer

PRKD1 KIF3C CTNNB1 CHMP2A SYNE1 RYR2 CHMP2B CEP57L1

3.27e-041187328GO:0099081
GeneOntologyCellularComponentmidbody

DTNBP1 CHMP2A SYNE1 CHMP2B

3.53e-04222324GO:0030496
GeneOntologyCellularComponentcation channel complex

AKAP6 STX1A RYR2 SLC5A3

4.37e-04235324GO:0034703
GeneOntologyCellularComponentkinetochore microtubule

CHMP2A CHMP2B

5.14e-0422322GO:0005828
GeneOntologyCellularComponentsarcomere

PRKD1 CTNNB1 SYNE1 RYR2

5.44e-04249324GO:0030017
GeneOntologyCellularComponentspindle

EVI5 CTNNB1 CHMP2A CDC16 CHMP2B

6.93e-04471325GO:0005819
GeneOntologyCellularComponentsarcoplasm

AKAP6 DTNBP1 RYR2

6.98e-04114323GO:0016528
GeneOntologyCellularComponentmyofibril

PRKD1 CTNNB1 SYNE1 RYR2

7.67e-04273324GO:0030016
GeneOntologyCellularComponentautophagosome

PRKD1 CHMP2A CHMP2B

7.91e-04119323GO:0005776
GeneOntologyCellularComponentcontractile muscle fiber

PRKD1 CTNNB1 SYNE1 RYR2

9.61e-04290324GO:0043292
GeneOntologyCellularComponentmultivesicular body membrane

CHMP2A CHMP2B

9.61e-0430322GO:0032585
GeneOntologyCellularComponentESCRT complex

CHMP2A CHMP2B

1.09e-0332322GO:0036452
GeneOntologyCellularComponentZ disc

PRKD1 CTNNB1 RYR2

1.57e-03151323GO:0030018
GeneOntologyCellularComponentSchaffer collateral - CA1 synapse

STX1A CTNNB1 DTNBP1

1.69e-03155323GO:0098685
GeneOntologyCellularComponentnuclear membrane

AKAP6 STX1A CTNNB1 SYNE1

1.90e-03349324GO:0031965
GeneOntologyCellularComponentI band

PRKD1 CTNNB1 RYR2

2.06e-03166323GO:0031674
GeneOntologyCellularComponentsarcoplasmic reticulum membrane

AKAP6 RYR2

2.16e-0345322GO:0033017
GeneOntologyCellularComponentmonoatomic ion channel complex

AKAP6 STX1A RYR2 SLC5A3

2.54e-03378324GO:0034702
GeneOntologyCellularComponentsarcolemma

AKAP6 DTNBP1 RYR2

3.02e-03190323GO:0042383
GeneOntologyCellularComponentpostsynaptic membrane

STX1A CTNNB1 DTNBP1 SYNE1

3.25e-03405324GO:0045211
GeneOntologyCellularComponentnuclear outer membrane-endoplasmic reticulum membrane network

AKAP6 EMC7 FMO3 DTNBP1 NFE2L1 SYNE1 RYR2

3.38e-031327327GO:0042175
GeneOntologyCellularComponentnuclear protein-containing complex

SMU1 TAF1 CTNNB1 CHMP2A SYNE1 CDC16 CHMP2B

4.15e-031377327GO:0140513
GeneOntologyCellularComponentpostsynaptic density

STX1A CTNNB1 DTNBP1 CHMP2B

4.77e-03451324GO:0014069
GeneOntologyCellularComponentintercalated disc

AKAP6 CTNNB1

4.86e-0368322GO:0014704
GeneOntologyCellularComponentorganelle envelope

AKAP6 STX1A CTNNB1 CHMP2A SYNE1 RYR2 CHMP2B

5.21e-031435327GO:0031967
GeneOntologyCellularComponentcalcium channel complex

AKAP6 RYR2

5.58e-0373322GO:0034704
GeneOntologyCellularComponentasymmetric synapse

STX1A CTNNB1 DTNBP1 CHMP2B

5.80e-03477324GO:0032279
GeneOntologyCellularComponentpostsynaptic specialization

STX1A CTNNB1 DTNBP1 CHMP2B

6.98e-03503324GO:0099572
GeneOntologyCellularComponentspindle microtubule

CHMP2A CHMP2B

7.66e-0386322GO:0005876
GeneOntologyCellularComponentneuron to neuron synapse

STX1A CTNNB1 DTNBP1 CHMP2B

8.00e-03523324GO:0098984
GeneOntologyCellularComponenttransmembrane transporter complex

AKAP6 STX1A RYR2 SLC5A3

8.00e-03523324GO:1902495
GeneOntologyCellularComponentsarcoplasmic reticulum

AKAP6 RYR2

8.01e-0388322GO:0016529
GeneOntologyCellularComponentmultivesicular body

CHMP2A CHMP2B

8.01e-0388322GO:0005771
GeneOntologyCellularComponentmicrotubule

KIF3C CHMP2A CHMP2B CEP57L1

8.53e-03533324GO:0005874
GeneOntologyCellularComponentvoltage-gated potassium channel complex

STX1A SLC5A3

8.54e-0391322GO:0008076
GeneOntologyCellularComponentcell-cell contact zone

AKAP6 CTNNB1

9.09e-0394322GO:0044291
GeneOntologyCellularComponenttransporter complex

AKAP6 STX1A RYR2 SLC5A3

9.51e-03550324GO:1990351
GeneOntologyCellularComponentnuclear pore

CHMP2A CHMP2B

1.04e-02101322GO:0005643
GeneOntologyCellularComponentsynaptic vesicle

STX1A KIF3C DTNBP1

1.07e-02300323GO:0008021
GeneOntologyCellularComponentpotassium channel complex

STX1A SLC5A3

1.10e-02104322GO:0034705
GeneOntologyCellularComponentsynaptic membrane

STX1A CTNNB1 DTNBP1 SYNE1

1.16e-02583324GO:0097060
GeneOntologyCellularComponentmicrotubule organizing center

TSGA10 EVI5 CTNNB1 CDC16 CEP57L1

1.22e-02919325GO:0005815
GeneOntologyCellularComponentneuron projection cytoplasm

KIF3C DTNBP1

1.23e-02110322GO:0120111
GeneOntologyCellularComponentcaveola

AKAP6 CTNNB1

1.25e-02111322GO:0005901
GeneOntologyCellularComponentendoplasmic reticulum membrane

AKAP6 EMC7 FMO3 DTNBP1 NFE2L1 RYR2

1.25e-021293326GO:0005789
GeneOntologyCellularComponentexocytic vesicle

STX1A KIF3C DTNBP1

1.27e-02320323GO:0070382
GeneOntologyCellularComponentendoplasmic reticulum subcompartment

AKAP6 EMC7 FMO3 DTNBP1 NFE2L1 RYR2

1.28e-021299326GO:0098827
GeneOntologyCellularComponentendosome membrane

RHOBTB1 DTNBP1 CHMP2A CHMP2B

1.29e-02602324GO:0010008
GeneOntologyCellularComponentperinuclear region of cytoplasm

AKAP6 PRKD1 CTNNB1 SYNE1 SLC5A3

1.30e-02934325GO:0048471
GeneOntologyCellularComponentcytoplasmic vesicle membrane

STX1A RHOBTB1 DTNBP1 CHMP2A NBEAL2 CHMP2B

1.32e-021307326GO:0030659
DomainSnf7_fam

CHMP2A CHMP2B

1.98e-0412332IPR005024
DomainSnf7

CHMP2A CHMP2B

1.98e-0412332PF03357
DomainSpectrin/alpha-actinin

AKAP6 SYNE1

1.45e-0332332IPR018159
DomainSPEC

AKAP6 SYNE1

1.45e-0332332SM00150
Pubmed

Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.

AKAP6 KIF3C DTNBP1 SYNE1 CEP57L1

3.63e-0715134517043677
Pubmed

The ESCRT-III isoforms CHMP2A and CHMP2B display different effects on membranes upon polymerization.

CHMP2A CHMP2B

9.28e-07234233832485
Pubmed

Phosphorylation-dependent regulation of ryanodine receptors: a novel role for leucine/isoleucine zippers.

AKAP6 RYR2

9.28e-07234211352932
Pubmed

Mutated in colorectal cancer, a putative tumor suppressor for serrated colorectal cancer, selectively represses beta-catenin-dependent transcription.

MCC CTNNB1

9.28e-07234218591935
Pubmed

Beta-catenin mediates alteration in cell proliferation, motility and invasion of prostate cancer cells by differential expression of E-cadherin and protein kinase D1.

PRKD1 CTNNB1

2.78e-06334217979146
Pubmed

Frequent inactivation of MCC/CTNNBIP1 and overexpression of phospho-beta-catenin(Y654) are associated with breast carcinoma: Clinical and prognostic significance.

MCC CTNNB1

2.78e-06334227208794
Pubmed

Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

RHOBTB1 SASH1 KLHL18 SYNE1

2.91e-061013449872452
Pubmed

ESCRT-III subunits Snf7-1 and Snf7-2 differentially regulate transmembrane cargos in hESC-derived human neurons.

CHMP2A CHMP2B

5.56e-06434221975012
Pubmed

ESCRT-III CHMP2A and CHMP3 form variable helical polymers in vitro and act synergistically during HIV-1 budding.

CHMP2A CHMP2B

5.56e-06434223051622
Pubmed

MCC inhibits beta-catenin transcriptional activity by sequestering DBC1 in the cytoplasm.

MCC CTNNB1

5.56e-06434224824780
Pubmed

Phospholipase Cε hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy.

AKAP6 RYR2

1.39e-05634223540699
Pubmed

ESCRT-III recognition by VPS4 ATPases.

CHMP2A CHMP2B

1.39e-05634217928862
Pubmed

LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.

TSGA10 SYNE1 CDC16 RYR2

2.18e-0516834430631154
Pubmed

Ab initio protein modelling reveals novel human MIT domains.

CHMP2A CHMP2B

2.59e-05834219302785
Pubmed

CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins.

CHMP2A CHMP2B

2.59e-05834211559748
Pubmed

Expression analysis of mouse Rhobtb3 using a LacZ reporter and preliminary characterization of a knockout strain.

CTNNB1 RHOBTB1

2.59e-05834224923387
Pubmed

ESCRT requirements for EIAV budding.

CHMP2A CHMP2B

2.59e-05834224107264
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

SMU1 MCC NADK PRKD1 KIF3C CTNNB1 DTNBP1 CDC16

3.19e-05132134827173435
Pubmed

Comprehensive analysis of the human ESCRT-III-MIT domain interactome reveals new cofactors for cytokinetic abscission.

CHMP2A CHMP2B

5.07e-051134236107470
Pubmed

Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease.

CHMP2A CHMP2B

5.07e-051134217984323
Pubmed

Phosphoproteome analysis of the human mitotic spindle.

EVI5 CHMP2A CDC16 CHMP2B

5.20e-0521034416565220
Pubmed

Structure of cellular ESCRT-III spirals and their relationship to HIV budding.

CHMP2A CHMP2B

6.08e-051234224878737
Pubmed

PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.

AKAP6 RYR2

6.08e-051234210830164
Pubmed

ESCRT machinery is required for plasma membrane repair.

CHMP2A CHMP2B

7.19e-051334224482116
Pubmed

The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor.

CHMP2A CHMP2B

7.19e-051334216554368
Pubmed

Secretory protein trafficking and organelle dynamics in living cells.

DTNBP1 CHMP2A CHMP2B

7.98e-058534311031247
Pubmed

ESCRT-III controls nuclear envelope reformation.

CHMP2A CHMP2B

8.38e-051434226040713
Pubmed

AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding.

CHMP2A CHMP2B

9.66e-051534214505569
Pubmed

Membrane scission by the ESCRT-III complex.

CHMP2A CHMP2B

9.66e-051534219234443
Pubmed

Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing.

CHMP2A CHMP2B

9.66e-051534226040712
Pubmed

Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a conserved VSL region in Vta1.

CHMP2A CHMP2B

9.66e-051534216505166
Pubmed

Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance.

CHMP2A CHMP2B

9.66e-051534220616062
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

AKAP6 TAF1 DTNBP1 NFE2L1 SYNE1

1.15e-0449734523414517
Pubmed

The protein network of HIV budding.

CHMP2A CHMP2B

1.41e-041834214505570
Pubmed

The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth.

STX1A DTNBP1

1.41e-041834219546860
Pubmed

Progenitor death drives retinal dysplasia and neuronal degeneration in a mouse model of ATRIP-Seckel syndrome.

STX1A CTNNB1

1.41e-041834232994318
Pubmed

Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins.

CHMP2A CHMP2B

1.41e-041834214519844
Pubmed

Differential Expression of NF2 in Neuroepithelial Compartments Is Necessary for Mammalian Eye Development.

STX1A CTNNB1

2.12e-042234229249622
Pubmed

Function of atypical protein kinase C lambda in differentiating photoreceptors is required for proper lamination of mouse retina.

STX1A CTNNB1

2.32e-042334216267237
Pubmed

Loss of connectin novex-3 leads to heart dysfunction associated with impaired cardiomyocyte proliferation and abnormal nuclear mechanics.

SYNE1 RYR2

2.74e-042534238877142
Pubmed

Screening the proteins that interact with calpain in a human heart cDNA library using a yeast two-hybrid system.

NFE2L1 SYNE1

2.74e-042534212358155
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

SAFB2 MCC PRKD1 CTNNB1 CABIN1 SYNE1

3.07e-0496334628671696
Pubmed

Mapping the interactome of HPV E6 and E7 oncoproteins with the ubiquitin-proteasome system.

DCAF15 KLHL18 CDC16

3.34e-0413834328786561
Pubmed

Membrane budding and scission by the ESCRT machinery: it's all in the neck.

CHMP2A CHMP2B

3.70e-042934220588296
Pubmed

Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated Proteins and Cellular Homeostasis.

CTNNB1 NFE2L1

4.24e-043134226222436
Pubmed

ESCRT-dependent control of craniofacial morphogenesis with concomitant perturbation of NOTCH signaling.

CHMP2A CHMP2B

4.24e-043134237573008
Pubmed

Lynch Syndrome

MCC CTNNB1

4.81e-043334220301390
Pubmed

DNA Damage Regulates Translation through β-TRCP Targeting of CReP.

ZNF395 CTNNB1

5.41e-043534226091241
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

AKAP6 SAFB2 NADK RHBDL2 NFE2L1 CEP57L1

5.76e-04108434611544199
Pubmed

Proteome-wide analysis of phospho-regulated PDZ domain interactions.

MCC EVI5

7.79e-044234230126976
Pubmed

Mapping the Genetic Landscape of Human Cells.

EMC7 TAF1 CHMP2A CDC16

9.51e-0445134430033366
InteractionAKAP6 interactions

AKAP6 DTNBP1 RYR2

2.68e-0617333int:AKAP6
InteractionDISC1 interactions

AKAP6 TSGA10 PRKD1 KIF3C SYNE1 CDC16 CEP57L1

4.99e-06429337int:DISC1
InteractionUSP54 interactions

DCAF15 CTNNB1 CHMP2A CDC16 CHMP2B

2.29e-05212335int:USP54
InteractionCOPS2 interactions

PRKD1 CTNNB1 RHOBTB1 KLHL18 CDC16

5.86e-05258335int:COPS2
InteractionZNF490 interactions

TSGA10 STX1A DTNBP1

7.44e-0550333int:ZNF490
InteractionLAD1 interactions

PRKD1 CTNNB1 KLHL18

9.37e-0554333int:LAD1
GeneFamilyCharged multivesicular body proteins|ESCRT-III

CHMP2A CHMP2B

3.84e-0572521118
GeneFamilyCharged multivesicular body proteins|ESCRT-III associated factors

CHMP2A CHMP2B

1.00e-0411252482
GeneFamilyBasic leucine zipper proteins|BTB domain containing

RHOBTB1 KLHL18

1.46e-02134252861
ToppCellcellseq2-Epithelial-Epithelial_Neuro-Secretory-Ionocyte|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TSGA10 RHBDL2 FMO3

2.44e-041603439049707a4487f2337a17976ceb5fbd8815ab9e1d
ToppCellcellseq2-Epithelial-Epithelial_Neuro-Secretory|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TSGA10 RHBDL2 FMO3

2.44e-041603430eb50b3c494e1b65d40104b3b5411b57bb72b959
ToppCellcellseq2-Epithelial-Epithelial_Neuro-Secretory-Ionocyte-Ionocyte|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TSGA10 RHBDL2 FMO3

2.44e-04160343f2cfec54cf48a655f473b830be7d141c54b521ff
ToppCellfacs-Marrow-Granulocytes-18m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SAFB2 MCC STX1A

2.76e-04167343528493896aebe7d03d4b6ad2341b12927859e2e4
ToppCellfacs-Marrow-Granulocytes-18m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SAFB2 MCC STX1A

2.76e-04167343a82e85caf79395baa48380786d9df32a86dfd1ce
ToppCellPND10-Immune-Immune_Myeloid-Granulocytic-Basophil-Basophil_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KLHL18 SYNE1 NBEAL2

3.01e-04172343c05af6e559f6af0fb15cefa03ffa1413e98a1a4a
ToppCellPND10-Immune-Immune_Myeloid-Granulocytic-Basophil|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KLHL18 SYNE1 NBEAL2

3.01e-04172343953b05f776348cff784e79c93df65841939d880f
ToppCellnormal_Lung-T/NK_cells-Exhausted_Tfh|normal_Lung / Location, Cell class and cell subclass

KIF3C RYR2 SLC5A3

3.06e-04173343e8ead6c51c41dbd43c717ba9d1a7a0ab39c79330
ToppCellnormal_Lung-T/NK_cells-Exhausted_Tfh|T/NK_cells / Location, Cell class and cell subclass

KIF3C RYR2 SLC5A3

3.11e-04174343e324320b52c904496e26fcecfa179b3431729ec0
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NADK FMO3 CCDC183

3.11e-041743433f0a5ce074675d57d479fa069385a1b3071e884e
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c05-ZNF683|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

SYNE1 NBEAL2 SLC5A3

3.22e-041763435914e7635474e7cf24d446bdb1423bc0807ee9c6
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-early_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF3C RHOBTB1 SASH1

3.22e-0417634388ca2f83d8301633232735f39b0683efe49d0b86
ToppCellASK452-Endothelial-Lymphatic|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq

PRKD1 KIF3C KLHL18

3.22e-04176343b4d280ecc07701d526f50d44c45ea91b3eeb00b1
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-early_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF3C RHOBTB1 SASH1

3.22e-041763437292e014b8f697f0c2e9f47c48333de95cb44a69
ToppCellCOVID-19-kidney-Stressed_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

MCC CTNNB1 SASH1

3.38e-04179343754f69bac7a1d5137f5141f6193285ccbfe361cb
ToppCellControl-Classical_Monocyte-cMono_4|Control / Disease condition and Cell class

STX1A CTNNB1 SLC5A3

3.50e-04181343f3e1d8fe5cf1eba19e51c3680a55306cae687fe9
ToppCellCOVID-19-Heart-CM_4|COVID-19 / Disease (COVID-19 only), tissue and cell type

AKAP6 RHBDL2 RYR2

3.61e-041833432902b6e8aa9a6f62bc1a792c971ab7f651a8e676
ToppCelldroplet-Kidney-nan-21m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NFE2L1 RYR2 SLC5A3

3.79e-041863438eafd4bea692f7ef33de27dd53f9d1fe67deaad8
ToppCelltumor_Lymph_Node_/_Brain-Fibroblasts-Undetermined|Fibroblasts / Location, Cell class and cell subclass

NADK CDC16 CEP57L1

3.79e-04186343403ac98f72a42721f84fbd7826f251a88ae534a2
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PRKD1 SASH1 SYNE1

3.79e-04186343f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

AKAP6 SYNE1 RYR2

3.79e-041863434780af76237d7af2abbe2d8d5530cdf53e3ed0b7
ToppCellCOVID-19-Fibroblasts-Airway_smooth_muscle|COVID-19 / group, cell type (main and fine annotations)

AKAP6 PRKD1 RYR2

3.85e-04187343464a0c3b92b778911b5f9cd73642e09e3472063a
ToppCellAdult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)|Adult / Lineage, Cell type, age group and donor

MCC SASH1 SYNE1

3.91e-04188343e5cad03f4a64147fe8174e7f614cf45233ffb9b7
ToppCellLA-13._Vascular_Smooth_Muscle|LA / Chamber and Cluster_Paper

AKAP6 PRKD1 RYR2

3.91e-0418834334e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCellfacs-Skin-nan-18m-Epithelial-Basal_IFE|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCC RHOBTB1 SYNE1

3.97e-041893436c71e81373cb7822de23c193a6350b6df9f567bc
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary-CAP2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MCC SASH1 SYNE1

3.97e-04189343b6b4da51bc7f2c13a2f940540fdc61027d084835
ToppCellChildren_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

MCC SASH1 SYNE1

4.03e-041903430a351609a72fd638c84b2435782e312ee6a33aac
ToppCellChildren_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

MCC SASH1 SYNE1

4.03e-041903430e9847d7f49b2236b8a191e1a7df37556351ba9e
ToppCellChildren_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)|Children_(3_yrs) / Lineage, Cell type, age group and donor

MCC SASH1 SYNE1

4.09e-04191343f229abf69a1217194f74b0502486907e07dba989
ToppCellLPS-IL1RA-Endothelial-Endothelial-Activated_Alv_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MCC RHOBTB1 SASH1

4.22e-04193343a3636c35ed25aabe2f1aba016c9fe125327bbfaf
ToppCellIPF-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

AKAP6 TSGA10 SYNE1

4.22e-04193343ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCellControl-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

PRKD1 FMO3 RYR2

4.22e-041933435896242f713ae5fd1a4ebb63827f15d7279dced2
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-10|TCGA-Colorectal / Sample_Type by Project: Shred V9

MCC PRKD1 EVC2

4.22e-04193343194e7fa00a50cc4e026987b715323d125d79594e
ToppCell(06)_Krt4/13+-(2)_48hpi|(06)_Krt4/13+ / shred by cell type and Timepoint

RHOBTB1 CHMP2B

4.25e-04403421e42cd186ee06ac9345e16ede649a72c15bdf2f8
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

AKAP6 TSGA10 SYNE1

4.28e-041943434a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCellLPS-antiTNF-Stromal_mesenchymal|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PRKD1 SYNE1 RYR2

4.28e-041943436e13549f697f7478b34fe71f7dd9d63c5d3db22e
ToppCellControl-Stromal-Myofibroblast|Control / Disease state, Lineage and Cell class

PRKD1 FMO3 RYR2

4.35e-04195343ffcf76cd72e43d8cf1058a49c76e0956065038bc
ToppCell5'-Adult-Appendix|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FMO3 SASH1 SYNE1

4.41e-04196343a579211ef14f348d0c5a290553150222dfbf1515
ToppCelldroplet-Kidney-nan-3m|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTNNB1 NFE2L1 SLC5A3

4.41e-04196343b880c9665d42c76ea1971d4e49d7ecf72fcfafb6
ToppCellCOVID-19-lung-Capillary_Aerocytes|lung / Disease (COVID-19 only), tissue and cell type

MCC SASH1 SYNE1

4.41e-041963434ac4073380d939a73cec7413e9f3f5ef616d2924
ToppCellCOVID-19-Heart-Mito_CM|COVID-19 / Disease (COVID-19 only), tissue and cell type

AKAP6 NFE2L1 RYR2

4.48e-0419734344e49943d62bfe622b40ad0460093d31540544df
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

AKAP6 TSGA10 SYNE1

4.48e-0419734374a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCelldistal-Epithelial-Ionocyte|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PRKD1 STX1A RHBDL2

4.48e-0419734311a5d2db2561d045756980ead61e1211c7dda100
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

AKAP6 SYNE1 RYR2

4.48e-04197343ac4f53acb2f8a428b0f2fab3c30a34e095a1bed7
ToppCelldistal-Epithelial-Ionocyte-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PRKD1 STX1A RHBDL2

4.48e-041973437a2cd970fe0866057999e40d15367b2b3324ae59
ToppCell3'-Adult-Distal_Rectal-Epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RHBDL2 CTNNB1 SLC5A3

4.54e-04198343ceede961ad9af6a3159db7efaa5087bf38aafc2d
ToppCellBronchial-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_systemic_arterial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

AKAP6 RHBDL2 RYR2

4.54e-04198343f261a37dd07976548b897af86df1d1a0dc069889
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

AKAP6 SYNE1 RYR2

4.54e-0419834322e766df1276c5b14aa0d83f434f47140ebb98ea
ToppCell3'-Adult-Distal_Rectal|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RHBDL2 CTNNB1 SLC5A3

4.54e-041983437ad7726fc405806b1d7824f58548073ea5e0c70b
ToppCell3'-Adult-Distal_Rectal-Epithelial-epithelial_progenitor_cell-TA|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RHBDL2 CTNNB1 SLC5A3

4.54e-041983431fbec311f2c987ca90a023a5989128c05aa12d5c
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

AKAP6 SYNE1 RYR2

4.54e-04198343c12e7511628db819a52959bb68580e27c00c2e41
ToppCell3'-Adult-Distal_Rectal-Epithelial-epithelial_progenitor_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RHBDL2 CTNNB1 SLC5A3

4.54e-041983434f26a60e99f42343e5af7221723e108a1a1b7827
ToppCell5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KIF3C SASH1 SYNE1

4.54e-0419834399d6a64f3410dae3019161feef20a8f06081a24b
ToppCellHematolymphoid-Endothelial-NOSTRIN---|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

PRKD1 SASH1 SYNE1

4.68e-0420034368fce28690246895fd33354b30960ebcc31aa4cc
ToppCellHematolymphoid-Endothelial-NOSTRIN|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

PRKD1 SASH1 SYNE1

4.68e-04200343032df80aa5c40991e1c1e80f9d8da106e6aeaee2
ToppCellControl_saline-Mesenchymal_myocytic-Pericyte-Pericyte_3|Control_saline / Treatment groups by lineage, cell group, cell type

AKAP6 SYNE1 RYR2

4.68e-04200343b0866b497aa71d06cef25f9a335fa584e95fa7e0
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Pericyte-Pericyte_3|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

AKAP6 SYNE1 RYR2

4.68e-04200343c06426f877919bdd267ea2fd7e7973c6619832ae
ToppCellLPS_only-Mesenchymal_myocytic-Pericyte|LPS_only / Treatment groups by lineage, cell group, cell type

AKAP6 SYNE1 RYR2

4.68e-042003438c8ef2b19ab5b1bfc0fae6c38a330f464f28e86f
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Pericyte-Pericyte_3|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

AKAP6 SYNE1 RYR2

4.68e-042003439169a9ec8e9ab95d90a64c5a19ac666a5cf82313
ToppCellHematolymphoid-Endothelial-NOSTRIN-|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

PRKD1 SASH1 SYNE1

4.68e-04200343376b19ab5a7cd2c85f726d8ba41337d4525863e5
ToppCellLPS_only-Mesenchymal_myocytic|LPS_only / Treatment groups by lineage, cell group, cell type

AKAP6 SYNE1 RYR2

4.68e-042003438bc9923f82bfb836e2f524204c92050edeae8ca5
ToppCellHematolymphoid-Endothelial-NOSTRIN----L2-6|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

PRKD1 SASH1 SYNE1

4.68e-04200343878bbbe32e3602723aa14ef32877ab2453b8c6e5
ToppCellHematolymphoid-Endothelial|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

PRKD1 SASH1 SYNE1

4.68e-042003437136936d05ab344a560cf159684c881063b5430d
ToppCellHematolymphoid-Endothelial-NOSTRIN--|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

PRKD1 SASH1 SYNE1

4.68e-042003437fa54370221ed61bac0e09e6bcf1f3dff202a846
ToppCellLPS_only-Mesenchymal_myocytic-Pericyte-Pericyte_3|LPS_only / Treatment groups by lineage, cell group, cell type

AKAP6 SYNE1 RYR2

4.68e-042003437c62678cf408aaaf98d6df0fb27814d2007c4521
DrugOxalamine citrate salt [1949-20-8]; Down 200; 9.2uM; MCF7; HT_HG-U133A

TSGA10 SAFB2 EVI5 DCAF15 KIF3C CABIN1 RYR2

1.16e-081913474969_DN
DrugStreptomycin sulfate [3810-74-0]; Down 200; 2.8uM; MCF7; HT_HG-U133A

SAFB2 MCC NADK KIF3C SASH1 CABIN1

4.27e-071973463195_DN
DrugDizocilpine maleate [77086-22-7]; Up 200; 11.8uM; HL60; HG-U133A

AKAP6 NADK EVI5 NFE2L1 KLHL18 NBEAL2

4.53e-071993461386_UP
DrugAC1ND2OB

SAFB2 PRKD1 TAF1 FMO3 CTNNB1 CHMP2A

2.40e-06265346CID004568637
DrugPHA-00851261E [724719-49-7]; Down 200; 10uM; PC3; HT_HG-U133A

NADK DCAF15 STX1A CABIN1 NBEAL2

9.23e-061923454330_DN
DrugEthynodiol diacetate [297-76-7]; Down 200; 10.4uM; MCF7; HT_HG-U133A

TSGA10 MCC STX1A TAF1 SASH1

9.47e-061933455024_DN
DrugMecamylamine hydrochloride [826-39-1]; Down 200; 19.6uM; MCF7; HT_HG-U133A

STX1A TAF1 CABIN1 NBEAL2 RYR2

9.95e-061953453525_DN
DrugAmodiaquin dihydrochloride dihydrate [6398-98-7]; Down 200; 8.6uM; MCF7; HT_HG-U133A

EVI5 STX1A KIF3C TAF1 SASH1

1.05e-051973453186_DN
DrugNaftifine hydrochloride [65473-14-5]; Down 200; 12.4uM; PC3; HT_HG-U133A

EVI5 KIF3C TAF1 SASH1 NBEAL2

1.05e-051973457273_DN
DrugRifampicin [13292-46-1]; Down 200; 4.8uM; MCF7; HT_HG-U133A

SAFB2 DCAF15 ZNF395 SASH1 CABIN1

1.07e-051983452847_DN
Drugtriphenylethylene

SAFB2 PRKD1 TAF1

4.42e-0546343CID000006025
DrugN-desmethyl-tamoxifen-hydrochloride

SAFB2 PRKD1 FMO3

6.40e-0552343CID000035887
Druglithium chromate

PRKD1 CTNNB1 DTNBP1 CHMP2A SYNE1

7.33e-05296345CID000026627
Druglithium aluminum hydride

PRKD1 CTNNB1 CABIN1 CHMP2A SYNE1

1.06e-04320345CID000028112
Drug4-nonylphenol

SAFB2 PRKD1 CABIN1

1.19e-0464343CID000001752
Drug2-phenylindole

SAFB2 TAF1

1.67e-0413342CID000013698
Drugoxazolidine

TAF1 SYNE1

1.67e-0413342CID000536683
DrugPromethazine hydrochloride [58-33-3]; Down 200; 12.4uM; PC3; HT_HG-U133A

SAFB2 MCC DCAF15 SLC5A3

1.76e-041893446717_DN
DrugEstradiol-17 beta [50-28-2]; Down 200; 14.6uM; PC3; HT_HG-U133A

MCC DCAF15 TAF1 SLC5A3

1.79e-041903446718_DN
DrugNiclosamide [50-65-7]; Down 200; 12.2uM; PC3; HT_HG-U133A

SAFB2 DCAF15 TAF1 RYR2

1.86e-041923444018_DN
DrugClenbuterol hydrochloride [21898-19-1]; Down 200; 12.8uM; PC3; HT_HG-U133A

MCC EVI5 KIF3C RHOBTB1

1.90e-041933444671_DN
DrugDantrolene sodium salt [14663-23-1]; Down 200; 11.8uM; PC3; HT_HG-U133A

NADK DCAF15 KLHL18 SLC5A3

1.90e-041933444343_DN
DrugBiperiden hydrochloride [1235-82-1]; Down 200; 11.4uM; MCF7; HT_HG-U133A

TSGA10 MCC STX1A TAF1

1.94e-041943443321_DN
DrugDirithromycin [62013-04-1]; Down 200; 4.8uM; MCF7; HT_HG-U133A

SAFB2 DCAF15 CABIN1 NBEAL2

1.94e-041943447446_DN
DrugAlthiazide [5588-16-9]; Down 200; 10.4uM; HL60; HT_HG-U133A

NADK EVI5 DCAF15 CDC16

1.94e-041943442527_DN
DrugSkimmianine [83-95-4]; Down 200; 15.4uM; HL60; HT_HG-U133A

NADK EVI5 RHOBTB1 CDC16

1.94e-041943442504_DN
DrugMethoxy-6-harmalan [3589-73-9]; Down 200; 18.6uM; MCF7; HT_HG-U133A

KIF3C TAF1 SASH1 CABIN1

1.98e-041953445455_DN
DrugAmiodarone hydrochloride [19774-82-4]; Down 200; 5.8uM; MCF7; HT_HG-U133A

NADK EVI5 NBEAL2 RYR2

1.98e-041953445618_DN
DrugPyrimethamine [58-14-0]; Down 200; 16uM; MCF7; HT_HG-U133A

TSGA10 NADK DCAF15 CABIN1

2.02e-041963444779_DN
Drug(-)-Eseroline fumarate salt [104015-29-4]; Down 200; 12uM; MCF7; HT_HG-U133A

SAFB2 DCAF15 TAF1 NBEAL2

2.02e-041963447027_DN
DrugPerhexiline maleate [6724-53-4]; Down 200; 10.2uM; PC3; HT_HG-U133A

SAFB2 MCC DCAF15 CABIN1

2.02e-041963445081_DN
Drugpioglitazone HCl; Down 200; 10uM; MCF7; HT_HG-U133A

NADK KIF3C TAF1 SASH1

2.02e-041963446898_DN
DrugSulindac [38194-50-2]; Down 200; 11.2uM; MCF7; HT_HG-U133A

DCAF15 SASH1 CABIN1 RYR2

2.02e-041963445528_DN
Drugbeta- Belladonnine dichloroethylate [191355-47-2]; Down 200; 6uM; MCF7; HT_HG-U133A

TSGA10 SAFB2 EVI5 DCAF15

2.02e-041963444984_DN
DrugAlclometasone dipropionate [667634-13-2]; Up 200; 7.6uM; MCF7; HT_HG-U133A

TSGA10 SAFB2 NADK TAF1

2.02e-041963446229_UP
DrugMeclocycline sulfosalicylate [73816-42-9]; Up 200; 5.8uM; MCF7; HT_HG-U133A

SAFB2 NADK STX1A TAF1

2.02e-041963443277_UP
DrugBetonicine [515-25-3]; Down 200; 25.2uM; MCF7; HT_HG-U133A

EVI5 STX1A KIF3C SYNE1

2.06e-041973444767_DN
DrugZaprinast [37762-06-4]; Up 200; 14.8uM; MCF7; HT_HG-U133A

SAFB2 NADK EVI5 TAF1

2.06e-041973445349_UP
DrugFuraltadone hydrochloride [3759-92-0]; Down 200; 11uM; HL60; HT_HG-U133A

EVI5 STX1A KIF3C RYR2

2.06e-041973442554_DN
DrugPhenindione [83-12-5]; Up 200; 18uM; HL60; HG-U133A

MCC EVI5 DCAF15 KLHL18

2.06e-041973441718_UP
DrugDiethylcarbamazine citrate [1642-54-2]; Down 200; 10.2uM; MCF7; HT_HG-U133A

SAFB2 MCC CABIN1 RYR2

2.06e-041973447425_DN
DrugHydrocotarnine hydrobromide [5985-00-2]; Down 200; 13.2uM; MCF7; HT_HG-U133A

SAFB2 NADK EVI5 STX1A

2.06e-041973442765_DN
DrugE)-4-hydroxytamoxifen

SAFB2 PRKD1 TAF1 CHMP2A

2.06e-04197344CID000063062
DrugCiprofibrate [52214-84-3]; Down 200; 13.8uM; MCF7; HT_HG-U133A

KIF3C SASH1 CABIN1 NBEAL2

2.06e-041973446218_DN
DrugAjmaline [4360-12-7]; Down 200; 12.2uM; MCF7; HT_HG-U133A

SAFB2 NADK STX1A TAF1

2.06e-041973442899_DN
DrugProcaine hydrochloride [51-05-8]; Up 200; 14.6uM; PC3; HT_HG-U133A

MCC NADK TAF1 NBEAL2

2.06e-041973441796_UP
DrugSulmazole [73384-60-8]; Down 200; 14uM; PC3; HT_HG-U133A

SAFB2 DCAF15 CABIN1 SYNE1

2.06e-041973444009_DN
DrugDeoxycorticosterone [64-85-7]; Down 200; 12.2uM; PC3; HT_HG-U133A

NADK EVI5 DCAF15 TAF1

2.06e-041973446758_DN
DrugCarcinine [56897-53-1]; Up 200; 22uM; MCF7; HT_HG-U133A

SAFB2 EVI5 TAF1 RYR2

2.06e-041973443242_UP
DrugBenzocaine [94-09-7]; Down 200; 24.2uM; MCF7; HT_HG-U133A

SAFB2 NADK SYNE1 RYR2

2.06e-041973442822_DN
Drug3-alpha-Hydroxy-5-beta-androstan-17-one [53-42-9]; Down 200; 13.8uM; MCF7; HT_HG-U133A

TSGA10 SAFB2 EVI5 SYNE1

2.06e-041973444764_DN
DrugMeclofenamic acid sodium salt monohydrate [6385-02-0]; Down 200; 11.8uM; MCF7; HT_HG-U133A

SAFB2 STX1A TAF1 CABIN1

2.06e-041973447038_DN
DrugLorglumide sodium salt [97964-56-2]; Down 200; 8.4uM; MCF7; HT_HG-U133A

SAFB2 MCC KIF3C SASH1

2.06e-041973446456_DN
DrugChlorphensin carbamate [886-74-8]; Down 200; 16.2uM; MCF7; HT_HG-U133A

SAFB2 NADK DCAF15 SASH1

2.06e-041973447472_DN
DrugAmiloride hydrochloride dihydrate [17440-83-4]; Down 200; 13.2uM; PC3; HT_HG-U133A

MCC EVI5 DCAF15 RYR2

2.10e-041983443990_DN
DrugMorantel tartrate [26155-31-7]; Up 200; 10.8uM; PC3; HT_HG-U133A

MCC NADK KIF3C CABIN1

2.10e-041983441798_UP
DrugOxymetazoline hydrochloride [2315-02-8]; Up 200; 13.4uM; HL60; HG-U133A

MCC DCAF15 KLHL18 NBEAL2

2.10e-041983441431_UP
DrugZidovudine, AZT [30516-87-1]; Up 200; 15uM; HL60; HG-U133A

NADK EVI5 DCAF15 SASH1

2.10e-041983441595_UP
DrugMethimazole [60-56-0]; Down 200; 35uM; MCF7; HT_HG-U133A

MCC NADK CABIN1 SLC5A3

2.10e-041983443898_DN
DrugCefotiam hydrochloride; Down 200; 7.2uM; HL60; HT_HG-U133A

SAFB2 MCC EVI5 STX1A

2.10e-041983442458_DN
DrugAjmalicine hydrochloride [4373-34-6]; Up 200; 10.2uM; HL60; HG-U133A

AKAP6 MCC NADK KLHL18

2.10e-041983441748_UP
DrugNitrendipine [39562-70-4]; Down 200; 11uM; MCF7; HT_HG-U133A

SAFB2 EVI5 DCAF15 RYR2

2.10e-041983445405_DN
DrugEtofenamate [30544-47-9]; Up 200; 10.8uM; MCF7; HT_HG-U133A

SAFB2 NADK EVI5 KIF3C

2.10e-041983447327_UP
DrugPrednicarbate [73771-04-7]; Down 200; 8.2uM; MCF7; HT_HG-U133A

SAFB2 MCC STX1A TAF1

2.10e-041983443542_DN
DrugReserpinic acid hydrochloride; Down 200; 9.2uM; PC3; HT_HG-U133A

MCC DCAF15 KIF3C CABIN1

2.10e-041983446603_DN
DrugBemegride [64-65-3]; Down 200; 25.8uM; PC3; HT_HG-U133A

MCC PRKD1 CABIN1 SYNE1

2.10e-041983446668_DN
DrugDexamethasone acetate [1177-87-3]; Down 200; 9.2uM; MCF7; HT_HG-U133A

NADK RHOBTB1 CABIN1 NBEAL2

2.10e-041983446271_DN
DrugProparacaine hydrochloride [5875-06-9]; Down 200; 12uM; MCF7; HT_HG-U133A

NADK KIF3C TAF1 RYR2

2.10e-041983445433_DN
DrugSuprofen [40828-46-4]; Down 200; 15.4uM; PC3; HT_HG-U133A

DCAF15 CABIN1 SYNE1 RYR2

2.10e-041983444005_DN
DrugBambuterol hydrochloride [81732-46-9]; Down 200; 10uM; PC3; HT_HG-U133A

STX1A KIF3C SASH1 RYR2

2.10e-041983445885_DN
DrugMethiothepin maleate [19728-88-2]; Down 200; 8.4uM; MCF7; HT_HG-U133A

SAFB2 MCC NADK RYR2

2.10e-041983443231_DN
DrugRicinine [524-40-3]; Up 200; 24.4uM; MCF7; HT_HG-U133A

AKAP6 TSGA10 SAFB2 SASH1

2.10e-041983446206_UP
DrugMetaproterenol sulfate, orciprenaline sulfate [5874-97-5]; Down 200; 7.6uM; MCF7; HT_HG-U133A

SAFB2 DCAF15 SASH1 NBEAL2

2.14e-041993444831_DN
Drugbeta- Belladonnine dichloroethylate [191355-47-2]; Down 200; 6uM; MCF7; HT_HG-U133A

DCAF15 STX1A SASH1 SYNE1

2.14e-041993442819_DN
DrugChenodiol [474-25-9]; Down 200; 10.2uM; MCF7; HT_HG-U133A

SAFB2 NADK SASH1 CABIN1

2.14e-041993447433_DN
DrugBenzamil hydrochloride [2898-76-2]; Down 200; 11.2uM; PC3; HT_HG-U133A

NADK DCAF15 CABIN1 RYR2

2.14e-041993444294_DN
DrugProbucol [23288-49-5]; Down 200; 7.8uM; MCF7; HT_HG-U133A

SAFB2 KIF3C NBEAL2 RYR2

2.14e-041993443223_DN
DrugNalidixic acid sodium salt hydrate; Down 200; 14.6uM; MCF7; HT_HG-U133A

SAFB2 EVI5 STX1A CABIN1

2.14e-041993444691_DN
Drugestradiol, USP; Down 200; 0.01uM; MCF7; HT_HG-U133A

SAFB2 KIF3C SASH1 CABIN1

2.14e-041993447000_DN
DrugAdiphenine hydrochloride [50-42-0]; Down 200; 11.4uM; PC3; HT_HG-U133A

SAFB2 NADK SASH1 NBEAL2

2.14e-041993447279_DN
DrugAtropine sulfate monohydrate [5908-99-6]; Up 200; 5.8uM; HL60; HG-U133A

MCC NADK DCAF15 KIF3C

2.14e-041993441768_UP
Drug4-hydroxytestosterone

SAFB2 CTNNB1 CHMP2A

2.14e-0478343CID000160615
DrugPheniramine maleate [132-20-7]; Up 200; 11.2uM; MCF7; HT_HG-U133A

TSGA10 STX1A CABIN1 SLC5A3

2.18e-042003441492_UP
DrugFluoxetine hydrochloride [59333-67-4]; Down 200; 11.6uM; HL60; HT_HG-U133A

SAFB2 STX1A KIF3C RHOBTB1

2.18e-042003442453_DN
DrugMoxisylyte hydrochoride [964-52-3]; Up 200; 12.6uM; HL60; HT_HG-U133A

KIF3C RHOBTB1 KLHL18 CHMP2B

2.18e-042003441846_UP
Drugcannon

DTNBP1 CHMP2A CHMP2B

2.67e-0484343CID003050747
Drug3-(1H-pyrrole-2-carboxylate

AKAP6 PRKD1 CABIN1 RYR2

3.89e-04233344CID000005114
DrugBT-B

TSGA10 PRKD1 CTNNB1 RHOBTB1

4.56e-04243344CID000081462
Diseaseurate measurement, bone density

AKAP6 MCC RHOBTB1 DTNBP1 CABIN1 SYNE1

4.74e-05619326EFO_0003923, EFO_0004531
DiseaseColorectal Carcinoma

AKAP6 MCC PRKD1 EVC2 CTNNB1 SYNE1

9.49e-05702326C0009402
DiseasePolyposis, Adenomatous Intestinal

MCC FMO3

1.35e-0416322C2713442
DiseaseFamilial Intestinal Polyposis

MCC FMO3

1.35e-0416322C2713443
DiseaseAdenomatous Polyposis Coli

MCC FMO3

1.53e-0417322C0032580
DiseaseAdenocarcinoma of large intestine

MCC TAF1 CTNNB1

1.55e-0496323C1319315
DiseaseColorectal cancer

MCC CTNNB1

3.93e-0427322cv:C0346629
DiseaseCOLORECTAL CANCER

MCC CTNNB1

3.93e-0427322114500
DiseaseNeoplasm of the large intestine

MCC CTNNB1

3.93e-0427322cv:C0009404
DiseaseMyopia

AKAP6 STX1A CTNNB1 RYR2

7.69e-04385324HP_0000545
DiseaseSalivary Gland Neoplasms

PRKD1 CTNNB1

1.19e-0347322C0036095
DiseaseIntellectual Disability

AKAP6 MCC TAF1 SYNE1

1.34e-03447324C3714756
DiseaseMetastatic melanoma

PRKD1 TAF1

1.57e-0354322C0278883

Protein segments in the cluster

PeptideGeneStartEntry
HMAANMLNKEMMETL

ANKRD61

206

A6NGH8
RQAEIMDMKEEMMND

CHMP2A

131

O43633
MDMKEEMMNDAIDDA

CHMP2A

136

O43633
ENMKMEMTEEMINDT

CHMP2B

131

Q9UQN3
DLMSIMEMQAMEVNT

NFE2L1

316

Q14494
MATQADLMELDMAME

CTNNB1

1

P35222
LMDDMEEAMVQDAEM

PRKD1

356

Q15139
SMEDMMNDINEKMEK

FMO3

401

P31513
MQQEMMLRDEETMEL

KIF3C

556

O14782
MEMEQEKMTMNKELS

NADK

1

O95544
QMNQAELMQLDMEGM

EVI5

361

O60447
MEVNVDMLEQMDLMD

DTNBP1

231

Q96EV8
MENQYQREMMAMEEA

EVC2

466

Q86UK5
EIEMNESDMMLETSM

CDC16

601

Q13042
LDLENAVLMQELMAM

MCC

611

P23508
AVLMQELMAMKEEMA

MCC

616

P23508
MMECKQDEIVMQGMD

KLHL18

71

O94889
MMLMSLSCMELQLDQ

CABIN1

541

Q9Y6J0
DMKIMSQDAMMITDE

CCDC183

206

Q5T5S1
LLMAMQDELDQMSME

CEP57L1

326

Q8IYX8
SDPDMRREMEQSMNM

EMC7

186

Q9NPA0
LMDLQKDMVVMLLSM

RYR2

3971

Q92736
LMNMMMMSDENHRDI

DCAF15

166

Q66K64
DLEMESMNLNMGREM

RHBDL2

6

Q9NX52
PMDMEAQLMDCQNML

SYNE1

6116

Q8NF91
QENTRMDMENEESMM

TAF1

1766

P21675
AMDMNVLMSAQLLME

NBEAL2

991

Q6ZNJ1
LMMAVMIAALMSDLD

SLC5A3

366

P53794
EMFDLRMMVENIMNK

RHOBTB1

441

O94844
IDMESLVMDSHDLMM

AKAP6

976

Q13023
AQDNFMMMDDAVLCM

SMU1

256

Q2TAY7
ELHDMFMDMAMLVES

STX1A

211

Q16623
FMDMAMLVESQGEMI

STX1A

216

Q16623
DAVEMDEMMAAMVLT

ZNF395

161

Q9H8N7
EITMSDEERIQLMMM

SASH1

181

O94885
MEASLENLQNMGMMD

SAFB2

116

Q14151
ENLQNMGMMDMSVLD

SAFB2

121

Q14151
MGMMDMSVLDETEVA

SAFB2

126

Q14151
DERMEQMSNMTLMKE

TSGA10

156

Q9BZW7