Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nucleocytoplasmic carrier activity	HIKESHI NUP214 IPO4	6.55e-05	32	49	3	GO:0140142
HumanPheno	Orbital cyst	PAX1 PAX2	2.54e-05	4	11	2	HP:0001144
Domain	PAX	PAX1 PAX2	2.11e-04	9	46	2	SM00351
Domain	PAX	PAX1 PAX2	2.11e-04	9	46	2	PF00292
Domain	Paired_dom	PAX1 PAX2	2.11e-04	9	46	2	IPR001523
Domain	PAIRED_2	PAX1 PAX2	2.11e-04	9	46	2	PS51057
Domain	PAIRED_1	PAX1 PAX2	2.11e-04	9	46	2	PS00034
Domain	ZnF_UBP	USP44 USP49	3.22e-04	11	46	2	SM00290
Domain	zf-UBP	USP44 USP49	5.30e-04	14	46	2	PF02148
Domain	ZF_UBP	USP44 USP49	5.30e-04	14	46	2	PS50271
Domain	Znf_UBP	USP44 USP49	5.30e-04	14	46	2	IPR001607
Domain	HEAT_type_2	IPO4 GCN1	7.88e-04	17	46	2	IPR021133
Domain	-	FOXD2 PAX1 PAX2 LARP1B	2.01e-03	218	46	4	1.10.10.10
Domain	WHTH_DNA-bd_dom	FOXD2 PAX1 PAX2 LARP1B	2.93e-03	242	46	4	IPR011991
Domain	GDS_CDC24_CS	ARHGEF5 ARHGEF12	4.15e-03	39	46	2	IPR001331
Domain	HEAT	IPO4 GCN1	6.23e-03	48	46	2	PF02985
Domain	VWA	COL28A1 ITIH5	8.40e-03	56	46	2	PF00092
Domain	HEAT	IPO4 GCN1	8.99e-03	58	46	2	IPR000357
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	USP44 USP49 YOD1 SAFB SARS2 TTC28 MTHFD1L ANKRD28 NUP214 IPO4 ALDH3A2 GCN1 SF3A2	9.09e-10	1005	49	13	19615732
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	SARS2 TTC28 MTHFD1L ANKRD28 NUP214 IPO4 TRIM27 CDC42EP1	1.95e-06	606	49	8	36538041
Pubmed	Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit.	CLCN7 TTC28 ARHGEF12 ANKRD28 IPO4 ALDH3A2 GCN1	3.07e-06	449	49	7	31732153
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	ZNF326 MRPL16 ARHGEF5 ARHGEF12 ANKRD28 NUP214 TRIM27 GCN1 SF3A2	4.68e-06	916	49	9	32203420
Pubmed	Murine developmental control genes.	PAX1 PAX2	5.83e-06	3	49	2	1974085
Pubmed	Pax genes and organogenesis.	PAX1 PAX2	1.16e-05	4	49	2	9297966
Pubmed	The oncogenic potential of Pax genes.	PAX1 PAX2	1.94e-05	5	49	2	8099544
Pubmed	Optical coherence tomography-guided Brillouin microscopy highlights regional tissue stiffness differences during anterior neural tube closure in the Mthfd1l murine mutant.	SOX10 MTHFD1L	1.94e-05	5	49	2	38682273
Pubmed	Mouse Mesenchyme forkhead 2 (Mf2): expression, DNA binding and induction by sonic hedgehog during somitogenesis.	FOXD2 PAX1	1.94e-05	5	49	2	9510020
Pubmed	C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways.	MTHFD1L IPO4 GCN1 SF3A2	2.45e-05	119	49	4	35776542
Pubmed	Molecular genetics of the Pax gene family.	PAX1 PAX2	2.91e-05	6	49	2	1485966
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	TTC28 ANKRD28 ALDH3A2 TRIM27 TRIM37 CDC42EP1	3.77e-05	446	49	6	24255178
Pubmed	The hairy ears (Eh) mutation is closely associated with a chromosomal rearrangement in mouse chromosome 15.	SOX10 PAX1	4.07e-05	7	49	2	2272507
Pubmed	Essential role of the TFIID subunit TAF4 in murine embryogenesis and embryonic stem cell differentiation.	SOX10 PAX2 TAF1L	4.92e-05	50	49	3	27026076
Pubmed	A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.	ARHGEF5 ARHGEF12 NUP214 TRIM27 GCN1	4.98e-05	284	49	5	29459677
Pubmed	Retinoic acid receptors exhibit cell-autonomous functions in cranial neural crest cells.	SOX10 PAX1	5.42e-05	8	49	2	19777591
Pubmed	Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion.	SDE2 SARS2 TCP11L1 CIR1 TRIM27 SF3A2 CDC42EP1	5.55e-05	704	49	7	32994395
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	LLGL1 TTC28 ARHGEF12 NUP214 ALDH3A2 GCN1 CDC42EP1	5.75e-05	708	49	7	39231216
Pubmed	Pax genes in development.	PAX1 PAX2	6.96e-05	9	49	2	7883790
Pubmed	ZRANB1 Is an EZH2 Deubiquitinase and a Potential Therapeutic Target in Breast Cancer.	USP44 USP49	6.96e-05	9	49	2	29669287
Pubmed	Pax genes and their role in organogenesis.	PAX1 PAX2	6.96e-05	9	49	2	10197584
Pubmed	Chromosomal localization of seven PAX genes and cloning of a novel family member, PAX-9.	PAX1 PAX2	6.96e-05	9	49	2	7981748
Pubmed	Spatiotemporal expression of Zic genes during vertebrate inner ear development.	SOX10 PAX2	8.69e-05	10	49	2	23606270
Pubmed	Differential deletion of GDNF in the auditory system leads to altered sound responsiveness.	SOX10 PAX2	8.69e-05	10	49	2	31663646
Pubmed	Loss of Gbx2 results in neural crest cell patterning and pharyngeal arch artery defects in the mouse embryo.	SOX10 PAX1	8.69e-05	10	49	2	15996652
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	ZNF326 TTC28 ANKRD28 IPO4 GCN1 TASOR2 CDC42EP1	1.03e-04	777	49	7	35844135
Pubmed	Pax3 Hypomorphs Reveal Hidden Pax7 Functional Genetic Compensation in Utero.	PAX1 PAX2	1.06e-04	11	49	2	35645295
Pubmed	Mitochondrial retention of Opa1 is required for mouse embryogenesis.	SOX10 PAX1	1.06e-04	11	49	2	20652258
Pubmed	Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.	ARHGEF5 IPO4 ALDH3A2 GCN1	1.31e-04	183	49	4	23956138
Pubmed	Collagen XXVIII is a distinctive component of the peripheral nervous system nodes of ranvier and surrounds nonmyelinating glial cells.	SOX10 COL28A1	1.50e-04	13	49	2	20830809
Pubmed	A physical map of the mouse shaker-2 region contains many of the genes commonly deleted in Smith-Magenis syndrome (del17p11.2p11.2).	LLGL1 ALDH3A2	1.50e-04	13	49	2	10049592
Pubmed	Tbx1 is required for proper neural crest migration and to stabilize spatial patterns during middle and inner ear development.	SOX10 PAX2	1.50e-04	13	49	2	15652707
Pubmed	Early ear neuronal development, but not olfactory or lens development, can proceed without SOX2.	SOX10 PAX2	1.50e-04	13	49	2	31526806
Pubmed	Dual embryonic origin of the mammalian otic vesicle forming the inner ear.	SOX10 PAX2	1.75e-04	14	49	2	22110056
Pubmed	Fibroblast growth factor signalling and regional specification of the pharyngeal ectoderm.	SOX10 PAX1	1.75e-04	14	49	2	16172976
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	ZNF326 MRPL16 TCP11L1 NUP214 ALDH3A2 GCN1 SF3A2 TASOR2	1.94e-04	1155	49	8	20360068
Pubmed	Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function.	PAX1 PAX2	2.02e-04	15	49	2	8837770
Pubmed	Mouse Nr2f1 haploinsufficiency unveils new pathological mechanisms of a human optic atrophy syndrome.	SOX10 PAX2	2.02e-04	15	49	2	31318166
Pubmed	Abnormal cerebellar development and Purkinje cell defects in Lgl1-Pax2 conditional knockout mice.	LLGL1 PAX2	2.02e-04	15	49	2	25050931
Pubmed	Characterization of the Gbx1-/- mouse mutant: a requirement for Gbx1 in normal locomotion and sensorimotor circuit development.	SOX10 PAX2	2.02e-04	15	49	2	23418536
Pubmed	Pax: a murine multigene family of paired box-containing genes.	PAX1 PAX2	2.02e-04	15	49	2	1685142
Pubmed	Synergy between Hoxa1 and Hoxb1: the relationship between arch patterning and the generation of cranial neural crest.	SOX10 PAX1	2.02e-04	15	49	2	11532923
Pubmed	LINC00941 promotes pancreatic cancer malignancy by interacting with ANXA2 and suppressing NEDD4L-mediated degradation of ANXA2.	SAFB TRIM27	2.02e-04	15	49	2	35977942
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	SARS2 LLGL1 CLCN7 MTHFD1L ANKRD28 IPO4 ALDH3A2 TRIM27 CDC42EP1	2.04e-04	1487	49	9	33957083
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	TTC28 ARHGEF12 ANKRD28 LARP1B	2.17e-04	209	49	4	36779422
Pubmed	A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export.	CLCN7 MTHFD1L ALDH3A2 TRIM27 GCN1	2.25e-04	392	49	5	33144569
Pubmed	Alx1 Deficient Mice Recapitulate Craniofacial Phenotype and Reveal Developmental Basis of ALX1-Related Frontonasal Dysplasia.	SOX10 PAX2	2.30e-04	16	49	2	35127681
Pubmed	Origins of oligodendrocytes in the cerebellum, whose development is controlled by the transcription factor, Sox9.	SOX10 PAX2	2.30e-04	16	49	2	26940020
Pubmed	Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D.	FOXD2 USP44	2.61e-04	17	49	2	22041458
Pubmed	The Mediator Subunit, Med23 Is Required for Embryonic Survival and Regulation of Canonical WNT Signaling During Cranial Ganglia Development.	SOX10 PAX2	2.93e-04	18	49	2	33192541
Pubmed	TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity.	TRIM27 TRIM37	2.93e-04	18	49	2	23077300
Pubmed	N-myc controls proliferation, morphogenesis, and patterning of the inner ear.	SOX10 PAX2	2.93e-04	18	49	2	21562282
Pubmed	Involvement of retinol dehydrogenase 10 in embryonic patterning and rescue of its loss of function by maternal retinaldehyde treatment.	PAX1 PAX2	2.93e-04	18	49	2	21930923
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	MTHFD1L ANKRD28 NUP214 IPO4 GCN1 TASOR2	3.01e-04	653	49	6	22586326
Pubmed	Bcl11a is required for neuronal morphogenesis and sensory circuit formation in dorsal spinal cord development.	SOX10 PAX2	3.27e-04	19	49	2	22491945
Pubmed	Gdf11 facilitates temporal progression of neurogenesis in the developing spinal cord.	SOX10 PAX2	3.27e-04	19	49	2	21248112
Pubmed	A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.	TTC28 MTHFD1L PAX2 NUP214 IPO4	3.48e-04	431	49	5	33660365
Pubmed	MicroRNAs are essential for the developmental switch from neurogenesis to gliogenesis in the developing spinal cord.	SOX10 PAX2	3.64e-04	20	49	2	20554876
Pubmed	FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues.	PAX1 PAX2	3.64e-04	20	49	2	15105374
Pubmed	Sox9 is required for invagination of the otic placode in mice.	SOX10 PAX2	3.64e-04	20	49	2	18377888
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	ZNF326 MTHFD1L ANKRD28 NUP214 IPO4 ALDH3A2 GCN1	4.07e-04	974	49	7	28675297
Pubmed	ATG5 is required for B cell polarization and presentation of particulate antigens.	SAFB SARS2 MRPL16 CIR1 TRIM27 GCN1	4.39e-04	701	49	6	30196744
Pubmed	SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function.	SOX10 PAX2	4.41e-04	22	49	2	17084361
Pubmed	Sox9 is critical for suppression of neurogenesis but not initiation of gliogenesis in the cerebellum.	SOX10 PAX2	4.41e-04	22	49	2	25888505
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	ZNF326 SAFB MRPL16 MTHFD1L NUP214 IPO4 GCN1 SF3A2	4.71e-04	1318	49	8	30463901
Pubmed	Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases.	USP44 USP49	4.83e-04	23	49	2	14715245
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	TTC28 ANKRD28 NUP214 GCN1 TASOR2	5.11e-04	469	49	5	27634302
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	ZNF326 SAFB LLGL1 MTHFD1L ANKRD28 NUP214 IPO4 GCN1	5.60e-04	1353	49	8	29467282
Pubmed	Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing.	ZNF326 SAFB SF3A2	5.66e-04	114	49	3	31553912
Pubmed	Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis.	PAX1 PAX2	5.71e-04	25	49	2	17035289
Pubmed	Olig1 function is required to repress dlx1/2 and interneuron production in Mammalian brain.	SOX10 PAX2	6.18e-04	26	49	2	24507192
Pubmed	Apurinic endonuclease-1 preserves neural genome integrity to maintain homeostasis and thermoregulation and prevent brain tumors.	SOX10 PAX2	6.18e-04	26	49	2	30538199
Pubmed	Mass spectrometry-based proteomic analysis of FSCN1-interacting proteins in laryngeal squamous cell carcinoma cells.	SAFB IPO4 GCN1	6.57e-04	120	49	3	31298480
Pubmed	Domain-specific control of neurogenesis achieved through patterned regulation of Notch ligand expression.	SOX10 PAX2	6.67e-04	27	49	2	20081190
Pubmed	Functional interactions between ubiquitin E2 enzymes and TRIM proteins.	TRIM27 TRIM37	6.67e-04	27	49	2	21143188
Pubmed	Penetrance of craniofacial anomalies in mouse models of Smith-Magenis syndrome is modified by genomic sequence surrounding Rai1: not all null alleles are alike.	LLGL1 ALDH3A2	6.67e-04	27	49	2	17273973
Pubmed	An FGF3-BMP Signaling Axis Regulates Caudal Neural Tube Closure, Neural Crest Specification and Anterior-Posterior Axis Extension.	SOX10 PAX1	6.67e-04	27	49	2	27144312
Pubmed	The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics.	CLCN7 ARHGEF12 ANKRD28	7.40e-04	125	49	3	29467281
Pubmed	Retinaldehyde dehydrogenase 2 (RALDH2)-mediated retinoic acid synthesis regulates early mouse embryonic forebrain development by controlling FGF and sonic hedgehog signaling.	SOX10 PAX2	8.25e-04	30	49	2	16368932
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	ZNF326 SAFB SARS2 LARP1B GCN1 SF3A2	9.16e-04	807	49	6	22681889
Pubmed	OTUD6A Is an Aurora Kinase A-Specific Deubiquitinase.	USP44 YOD1	9.39e-04	32	49	2	33669244
Pubmed	Ubiquitin-specific peptidase 2a (USP2a) deubiquitinates and stabilizes β-catenin.	USP49 YOD1	9.98e-04	33	49	2	30323974
Pubmed	KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and lysosome-mediated degradation.	SARS2 NUP214	9.98e-04	33	49	2	25582440
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	ZNF326 MTHFD1L ARHGEF12 IPO4 ALDH3A2 TRIM27 TAF1L SF3A2	1.08e-03	1497	49	8	31527615
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	LLGL1 ARHGEF12 NUP214 GCN1 CDC42EP1	1.18e-03	565	49	5	25468996
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	ZNF326 KCNQ5 TTC28 ARHGEF5 LARP1B CDC42EP1	1.28e-03	861	49	6	36931259
GeneFamily	Paired boxes	PAX1 PAX2	1.30e-04	9	35	2	675
GeneFamily	Ubiquitin specific peptidases	USP44 USP49	5.25e-03	56	35	2	366
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGEF5 ARHGEF12	7.23e-03	66	35	2	722
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	TRIM27 TRIM37	1.45e-02	95	35	2	59
Disease	cup-to-disc ratio measurement	FOXD2 TTC28 MTHFD1L HNRNPA1L3 CDC42EP1	6.57e-04	430	48	5	EFO_0006939
Disease	cataract	KCNQ5 TTC28 METRNL	1.58e-03	141	48	3	MONDO_0005129
Disease	breast cancer, ovarian carcinoma	TTC28 ARHGEF5	1.66e-03	37	48	2	EFO_0001075, MONDO_0007254
Disease	optic disc area measurement	HNRNPA1L3 CDC42EP1	2.45e-03	45	48	2	EFO_0006937
Disease	DNA methylation	BPIFB3 DPP10 MTHFD1L COL28A1 HNRNPA1L3	4.16e-03	656	48	5	GO_0006306
Disease	proliferative diabetic retinopathy	DPP10 KCNQ5	4.46e-03	61	48	2	EFO_0009322
Disease	optic disc size measurement	KCNQ5 HNRNPA1L3 CDC42EP1	4.54e-03	205	48	3	EFO_0004832

Protein segments in the cluster

Peptide	Gene	Start	Entry
HQGHRMGDGTPGRPK	ERVPABLB-1	21	P60509
HTKVGMHCSGPLGGL	BPIFB3	116	P59826
LGHKMHVLDLGGGFP	AZIN2	226	Q96A70
RGGHMNSGGHAKTRP	ARHGEF5	866	Q12774
SGADTAKRGIHGMFP	ANKRD28	361	O15084
GVGSSGMGAYHGKHS	ALDH3A2	401	P51648
GGGVMGSLKTHHGIC	AADACL3	121	Q5VUY0
ALKMHGGGPSVTAGV	MTHFD1L	746	Q6UB35
MTVPVKQGGRGEFHH	DPP10	386	Q8N608
STHEMGHGGPEAAVR	EFCC1	241	Q9HA90
YHSGEGHMPFRTGTG	ARHGEF12	1306	Q9NZN5
MKGGNFEGRSSGPHG	HNRNPA1L3	231	A0A2R8Y4L2
MFGPAKGRHFGVHPA	YOD1	1	Q5VVQ6
SGGHFIIFSGGMPRA	LLGL1	301	Q15334
GTPGPHKMEHGGRVV	LRIG1	916	Q96JA1
RDGKVYIHHMSPTGG	ITIH5	356	Q86UX2
SDERHGHGPSGKPML	GABRQ	506	Q9UN88
MPRHHAGGEEGGAAG	KCNQ5	1	Q9NR82
GLAVGKEGPMIHSGS	CLCN7	241	P51798
AKSHLVHGSSPGVMG	NUP214	1036	P35658
GMGFLMRHHIETGGG	GCN1	2531	Q92616
GVRPGHGDFLFTGHM	METRNL	261	Q641Q3
MHGLGHVFGPGSLSL	ASIC3	26	Q9UHC3
KADPFSAMHPGHGGV	PAX2	6	Q02962
KMGSHPGVPGTAGHV	PAX1	266	P15863
GLKSGEGSQHPFGAM	HIKESHI	86	Q53FT3
TMGHGLPGQKGEHGE	COL28A1	726	Q2UY09
GLSPMHHAGFKTFGI	B3GNT4	316	Q9C0J1
PLGDFRHTMHVGRGG	CDC42EP1	41	Q00587
TSGMGFHAPKIGSNG	SDE2	241	Q6IQ49
FGMGVLAEHGGHPAQ	IPO4	921	Q8TEX9
HPGGDRTGTHMSRAK	LARP1B	461	Q659C4
SFSIDHIMGHGGGGA	FOXD2	411	O60548
VGHRMGGGKGAIDHY	MRPL16	136	Q9NX20
HHFTKVEMFGVTGPG	SARS2	346	Q9NP81
KHALPVGGMAAGSGD	TCP11L1	281	Q9NUJ3
PMSGIDGFSGHVGNH	TRIM27	491	P14373
GGMHGGHTFKPLAEI	TRIM37	121	O94972
AHSGEGPMSKFARGS	TAF1L	1056	Q8IZX4
MDFQHRPGGKTGSGG	SF3A2	1	Q15428
GGERSMSGHSGPGHM	SAFB	851	Q15424
GEKMYREHPGGTHTK	CIR1	431	Q86X95
RSMGEGGKPHIDFGN	SOX10	261	P56693
SAVVMHHGKGFGSGH	USP49	601	Q70CQ1
HMVSEGGPRGTFHKG	ZNF469	3626	Q96JG9
GGLMHSSGPVGRHRQ	TTC28	1406	Q96AY4
PDFGGKQMGLHGLHL	TASOR2	141	Q5VWN6
LSAVVMHHGKGFGSG	USP44	621	Q9H0E7
GRGRGHMGDFGSIHR	ZNF326	201	Q5BKZ1