Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-25 ERVK-9	4.48e-10	37	51	6	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-25 ERVK-9	5.31e-10	38	51	6	GO:0070001
GeneOntologyMolecularFunction	RNA-directed DNA polymerase activity	ERVK-6 ERVK-8 TEP1	5.60e-06	14	51	3	GO:0003964
GeneOntologyMolecularFunction	endopeptidase activity	ERVK-6 ADAM15 ERVK-8 ERVK-19 ERVK-21 ERVK-25 ERVK-9	1.05e-04	430	51	7	GO:0004175
GeneOntologyMolecularFunction	RNA endonuclease activity, producing 5'-phosphomonoesters	ERVK-6 ERVK-8 ELAC2	1.15e-04	37	51	3	GO:0016891
GeneOntologyMolecularFunction	DNA polymerase activity	ERVK-6 ERVK-8 TEP1	1.24e-04	38	51	3	GO:0034061
GeneOntologyMolecularFunction	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	ERVK-6 ERVK-8 ELAC2	2.21e-04	46	51	3	GO:0016893
GeneOntologyMolecularFunction	RNA-DNA hybrid ribonuclease activity	ERVK-6 ERVK-8	3.47e-04	11	51	2	GO:0004523
GeneOntologyMolecularFunction	structural molecule activity	ERVK-6 MXRA5 ANK1 ERVK-8 ERVK-19 ERVK-21 ERVK-25 ERVK-9 RPL15	3.79e-04	891	51	9	GO:0005198
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	ERVK-6 BPTF ERVK-8 TEP1 DHX30	5.37e-04	262	51	5	GO:0140097
GeneOntologyMolecularFunction	RNA endonuclease activity	ERVK-6 ERVK-8 ELAC2	1.08e-03	79	51	3	GO:0004521
GeneOntologyMolecularFunction	peptidase activity	ERVK-6 ADAM15 ERVK-8 ERVK-19 ERVK-21 ERVK-25 ERVK-9	1.30e-03	654	51	7	GO:0008233
GeneOntologyMolecularFunction	RNA stem-loop binding	ERVK-6 ERVK-8	1.30e-03	21	51	2	GO:0035613
GeneOntologyMolecularFunction	cytoskeletal anchor activity	ANK1 GAS2L2	1.70e-03	24	51	2	GO:0008093
GeneOntologyMolecularFunction	histone modifying activity	HDAC9 SETD1A BAZ1A RIOX1	2.76e-03	229	51	4	GO:0140993
GeneOntologyMolecularFunction	nuclease activity	ERVK-6 EXD3 ERVK-8 ELAC2	2.85e-03	231	51	4	GO:0004518
GeneOntologyBiologicalProcess	cell-cell fusion	ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9 EHD2	5.63e-08	85	50	6	GO:0140253
GeneOntologyBiologicalProcess	syncytium formation by plasma membrane fusion	ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9 EHD2	5.63e-08	85	50	6	GO:0000768
GeneOntologyBiologicalProcess	syncytium formation	ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9 EHD2	7.42e-08	89	50	6	GO:0006949
GeneOntologyBiologicalProcess	RNA-templated DNA biosynthetic process	ERVK-6 ERVK-8 TNKS1BP1 TEP1	4.88e-05	83	50	4	GO:0006278
Domain	DDT	BPTF BAZ1A	3.10e-05	4	43	2	PF02791
Domain	DDT	BPTF BAZ1A	5.15e-05	5	43	2	SM00571
Domain	WSD	BPTF BAZ1A	5.15e-05	5	43	2	PF15613
Domain	WHIM1	BPTF BAZ1A	5.15e-05	5	43	2	PF15612
Domain	DDT_dom	BPTF BAZ1A	5.15e-05	5	43	2	IPR018501
Domain	WHIM1_dom	BPTF BAZ1A	5.15e-05	5	43	2	IPR028942
Domain	WHIM2_dom	BPTF BAZ1A	5.15e-05	5	43	2	IPR028941
Domain	DDT	BPTF BAZ1A	7.72e-05	6	43	2	PS50827
Domain	PHD	BPTF BAZ1A RAI1	1.12e-03	89	43	3	SM00249
Domain	Znf_PHD	BPTF BAZ1A RAI1	1.20e-03	91	43	3	IPR001965
Domain	ZF_PHD_2	BPTF BAZ1A RAI1	1.36e-03	95	43	3	PS50016
Domain	ZF_PHD_1	BPTF BAZ1A RAI1	1.40e-03	96	43	3	PS01359
Domain	Bromodomain_CS	BPTF BAZ1A	1.62e-03	26	43	2	IPR018359
Domain	BROMODOMAIN_1	BPTF BAZ1A	3.28e-03	37	43	2	PS00633
Domain	Bromodomain	BPTF BAZ1A	3.45e-03	38	43	2	PF00439
Domain	BROMODOMAIN_2	BPTF BAZ1A	4.01e-03	41	43	2	PS50014
Domain	BROMO	BPTF BAZ1A	4.20e-03	42	43	2	SM00297
Domain	Bromodomain	BPTF BAZ1A	4.20e-03	42	43	2	IPR001487
Domain	-	BPTF BAZ1A	4.20e-03	42	43	2	1.20.920.10
Domain	Zinc_finger_PHD-type_CS	BPTF BAZ1A	9.82e-03	65	43	2	IPR019786
Domain	RNaseH-like_dom	ERVK-6 EXD3	1.10e-02	69	43	2	IPR012337
Pubmed	Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.	ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9	6.45e-12	12	55	5	14557543
Pubmed	A revised nomenclature for transcribed human endogenous retroviral loci.	ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-25 ERVK-9	8.64e-09	94	55	6	21542922
Pubmed	Quantitation of HERV-K env gene expression and splicing in human breast cancer.	ERVK-6 ERVK-19 ERVK-21	3.73e-08	5	55	3	12629516
Pubmed	Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.	ERVK-6 ERVK-19 ERVK-9	7.46e-08	6	55	3	15063128
Pubmed	Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.	ERVK-6 ERVK-19 ERVK-21	4.46e-07	10	55	3	12970426
Pubmed	Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.	ERVK-6 ERVK-19	2.46e-06	2	55	2	9060628
Pubmed	Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.	ERVK-6 ERVK-19	2.46e-06	2	55	2	9460924
Pubmed	Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.	ERVK-21 ERVK-25 ERVK-9	3.00e-06	18	55	3	18664271
Pubmed	Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.	ERVK-6 ERVK-19	7.36e-06	3	55	2	10516026
Pubmed	Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.	ERVK-6 ERVK-9	7.36e-06	3	55	2	9971820
Pubmed	Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.	ERVK-6 ERVK-19	1.47e-05	4	55	2	7983737
Pubmed	Setd1a and NURF mediate chromatin dynamics and gene regulation during erythroid lineage commitment and differentiation.	BPTF SETD1A	2.45e-05	5	55	2	27141965
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SETD1A ZNF48 PLEKHO2 TNKS1BP1 TEP1 ELAC2 ADCY7 RAI1 DHX30	5.46e-05	1105	55	9	35748872
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	BCL9L BPTF SETD1A BAZ1A TNKS1BP1 ZNF831	9.65e-05	469	55	6	27634302
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	MXRA5 ANK1 TRIM9 ZFR2 ROR1 ZNF831 RAI1	1.55e-04	736	55	7	29676528
Pubmed	Interaction network of human early embryonic transcription factors.	BCL9L BPTF SETD1A BAZ1A RAI1	2.34e-04	351	55	5	38297188
Pubmed	Chromatin boundaries require functional collaboration between the hSET1 and NURF complexes.	BPTF SETD1A	3.29e-04	17	55	2	21653943
Pubmed	USF1 recruits histone modification complexes and is critical for maintenance of a chromatin barrier.	BPTF SETD1A	3.70e-04	18	55	2	17846119
Pubmed	Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios.	PARD3 TEP1	4.13e-04	19	55	2	14671302
Pubmed	The treasury of the commons: making use of public gene expression resources to better characterize the molecular diversity of inhibitory interneurons in the cerebellar cortex.	SBK1 VGF TRIM9	5.12e-04	98	55	3	19554387
Pubmed	F-box protein FBXL16 binds PP2A-B55α and regulates differentiation of embryonic stem cells along the FLK1+ lineage.	RPL15 DHX30	6.08e-04	23	55	2	24390425
Pubmed	The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.	TNKS1BP1 ELAC2 RPL15 EHD2	1.28e-03	298	55	4	30737378
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SETD1A CAMKK2 TRIM9 TNKS1BP1 RAI1	1.49e-03	529	55	5	14621295
Disease	platelet-to-lymphocyte ratio	HDAC9 ANK1 TNKS1BP1 ZNF831 RAI1	2.75e-04	363	47	5	EFO_0008446
Disease	Schizophrenia	HDAC9 SETD1A AHI1-DT CAMKK2 ERVK-8 ADCY7 RAI1	4.65e-04	883	47	7	C0036341
Disease	Ischemic stroke, factor VII measurement	HDAC9 PARD3	9.81e-04	29	47	2	EFO_0004619, HP_0002140
Disease	loneliness measurement	HDAC9 BPTF EXD3	1.03e-03	124	47	3	EFO_0007865
Disease	autoimmune thyroid disease	AHI1-DT GPR25 ADCY7	1.07e-03	126	47	3	EFO_0006812
Disease	Ovarian Mucinous Adenocarcinoma	SBK1 ROR1	1.12e-03	31	47	2	C1335167
Disease	Polynesian Bronchiectasis	GAS2L2 CCNO	1.43e-03	35	47	2	C4317124
Disease	Ciliary Dyskinesia, Primary, 1, With Or Without Situs Inversus	GAS2L2 CCNO	1.43e-03	35	47	2	C4551906
Disease	Kartagener Syndrome	GAS2L2 CCNO	1.43e-03	35	47	2	C0022521
Disease	systemic lupus erythematosus	SBK1 AHI1-DT TMC2 ADAM15 ZNF831 RAB44	1.61e-03	799	47	6	MONDO_0007915
Disease	brain measurement, neuroimaging measurement	HDAC9 BPTF ROR1 PARD3 ELAC2	1.78e-03	550	47	5	EFO_0004346, EFO_0004464
Disease	disorder of pharynx	CARMIL2 GAS2L2	2.46e-03	46	47	2	MONDO_0020592
Disease	pneumonia	BCL9L EXD3	2.56e-03	47	47	2	EFO_0003106
Disease	Primary Ciliary Dyskinesia	GAS2L2 CCNO	2.56e-03	47	47	2	C4551720
Disease	systemic lupus erythematosus, COVID-19	ADAM15 ZFP57	3.88e-03	58	47	2	MONDO_0007915, MONDO_0100096
Disease	mosquito bite reaction size measurement	SBK1 FOXQ1 ADAM15	4.70e-03	212	47	3	EFO_0008378

Protein segments in the cluster

Peptide	Gene	Start	Entry
PPRRRRHRNRAPLTH	ERVK-25	11	P61579
PPRRRRHRNRAPLTH	ERVK-19	11	O71037
PPRRRRHRNRAPLTH	ERVK-8	11	Q902F8
PPRRRRHRNRAPLTH	ERVK-9	11	Q9UKH3
KSRRPRLRRKQPLHP	CCNO	31	P22674
KPPEHPLGQRHIRRR	ADAM15	191	Q13444
CLPLRPHRPTRRHRR	BBC3	91	Q96PG8
LRHPTRARPRPRRQH	CARMIL2	1016	Q6F5E8
RARPRPRRQHHHRPP	CARMIL2	1021	Q6F5E8
PRRRKFHRPIGLRIP	ANK1	1136	P16157
LPRRLVPPSKRRHKG	EHD2	526	Q9NZN4
RPPHVGRARRNSLRI	GPR25	231	O00155
HGDRCVPRSRRRPRP	AHI1-DT	126	P0C7V0
GRRPKSVPQRHRRTP	ADCY7	516	P51828
RAQHRQRQCKLPPPR	DHX30	11	Q7L2E3
RRKPRVHRPRSPILE	BPTF	206	Q12830
PANRRRGRPPKRIHI	BAZ1A	271	Q9NRL2
PVPRGKSLRSRRVHR	RAI1	991	Q7Z5J4
PPRRRRHRNRAPLTH	HERVK_113	11	P61574
PPRRRRHRNRAPLTH	ERVK-19	11	P61572
PPRRRRHRNRAPLTH	ERVK-21	11	P61571
PPRRRRHRNRAPLTH	ERVK-6	11	Q69383
PPRRRRHRNRAPLTH	ERVK-9	11	P61573
PHRLRRRKPLPSKRV	RAB44	116	Q7Z6P3
CRRRLIPHPRRLSPV	CDRT15	26	Q96T59
KRLRHRGRAVQRPLP	GP6	296	Q9HCN6
LRKPPAVGRNRRHHR	NUS1	56	Q96E22
VPRLRPRHRHPQDPR	HRES1	36	P13985
PPRRRRHRNRAPLTH	ERVK-25	11	P61570
PPRRRRHRNRAPLTH	ERVK-6	11	Q69384
RPRRDHRPEKQPSRI	GAS2L2	781	Q8NHY3
NKTRLPHPRRREAPG	BCL9L	6	Q86UU0
PPRRRRHRNRAPLTH	ERVK-21	11	P61565
LKEARQRRQPPGHRP	CAMKK2	531	Q96RR4
PPRRRRHRNRAPLTH	HERVK_113	11	Q902F9
ERHRREQQLPPLRGK	HDAC9	116	Q9UKV0
LRRRPSHRARKPPGD	SBK1	321	Q52WX2
RRRKRLSHRAPVPAP	FOXQ1	211	Q9C009
GRPHPRVPQALVRRL	HS3ST6	306	Q96QI5
IPFHRPRPRIIRGRG	PARD3	906	Q8TEW0
ARRPIAQRHPLRPAR	SYT8	366	Q8NBV8
RPRTLQPPSALRRRH	VGF	551	O15240
ERRRAVRLPHGRPLP	GPR150	146	Q8NGU9
APRLPHPAARARRRA	PRR34	81	Q9NV39
PKRKRRPQDGPREHQ	SETD1A	1476	O15047
LRRGRPKRRRKPQPH	RIOX1	11	Q9H6W3
PWQKPTSPRRLHRRR	CSNK1G2-AS1	26	Q8NCQ2
TSPRRLHRRRPRGQP	CSNK1G2-AS1	31	Q8NCQ2
QHPRPRRTKGPGLRK	LINC00477	141	Q96M19
MHRPRRRGTRPPLLA	ROR1	1	Q01973
KHLRTHRGERARPPP	ZNF48	496	Q96MX3
QKLRRGVAPRQPRIP	UNC93B1	516	Q9H1C4
LPPRHRLGARFRKRQ	ZFR2	901	Q9UPR6
PPRIHTPRRRGLREK	ZFP57	421	Q9NU63
PARRERPRKDPLRHL	ELAC2	26	Q9BQ52
NPRKHRAKRHPRRPP	TEP1	381	Q99973
LHRAPRPTRPDKARR	RPL15	36	P61313
NLGRKRGHRAPVIRP	TNKS1BP1	1576	Q9C0C2
PPRRRRHRNRAPLTH	ERVK-8	11	P61575
KHRLVPPAQGRVSRR	TRIM9	206	Q9C026
RGGQRRRPPTRVHLK	PLEKHO2	146	Q8TD55
PGSPRRKQTGRRRHR	TMC2	66	Q8TDI7
RRRSRHPPALEGLKP	ZNF831	1316	Q5JPB2
PNGRRRLRPNKFRHR	MXRA5	1151	Q9NR99
RHRERPGARKPPGLQ	EXD3	586	Q8N9H8