Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	steroid hormone binding	ATP1A1 ATP1A2 ATP1A3	9.41e-07	7	61	3	GO:1990239
GeneOntologyMolecularFunction	ATPase-coupled transmembrane transporter activity	ABCA1 ATP6V0A4 ATP1A1 ATP1A2 ATP1A3 ABCB1	1.00e-06	109	61	6	GO:0042626
GeneOntologyMolecularFunction	P-type sodium transporter activity	ATP1A1 ATP1A2 ATP1A3	3.21e-06	10	61	3	GO:0008554
GeneOntologyMolecularFunction	P-type sodium:potassium-exchanging transporter activity	ATP1A1 ATP1A2 ATP1A3	3.21e-06	10	61	3	GO:0005391
GeneOntologyMolecularFunction	P-type transmembrane transporter activity	ATP6V0A4 ATP1A1 ATP1A2 ATP1A3	4.31e-06	36	61	4	GO:0140358
GeneOntologyMolecularFunction	P-type ion transporter activity	ATP6V0A4 ATP1A1 ATP1A2 ATP1A3	4.31e-06	36	61	4	GO:0015662
GeneOntologyMolecularFunction	P-type potassium transmembrane transporter activity	ATP1A1 ATP1A2 ATP1A3	4.40e-06	11	61	3	GO:0008556
GeneOntologyMolecularFunction	phosphatidylinositol 3-kinase binding	DAB2IP JAK2 IRS1 ATP1A1	8.90e-06	43	61	4	GO:0043548
GeneOntologyMolecularFunction	primary active transmembrane transporter activity	ABCA1 ATP6V0A4 ATP1A1 ATP1A2 ATP1A3 ABCB1	1.71e-05	178	61	6	GO:0015399
GeneOntologyMolecularFunction	ATPase-coupled monoatomic cation transmembrane transporter activity	ATP6V0A4 ATP1A1 ATP1A2 ATP1A3	3.85e-05	62	61	4	GO:0019829
GeneOntologyMolecularFunction	sphingolipid floppase activity	ABCA1 ABCB1	5.49e-05	4	61	2	GO:0046623
GeneOntologyMolecularFunction	ATP hydrolysis activity	ABCA1 NLRP10 IGHMBP2 ATP1A1 ATP1A2 ATP1A3 POLQ ABCB1	5.61e-05	441	61	8	GO:0016887
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	SLC6A1 CACNG6 TRPM5 PKD1L1 ATP1A1 MAGT1 ATP1A2 ATP1A3	8.13e-05	465	61	8	GO:0046873
GeneOntologyMolecularFunction	ATP-dependent activity	ABCA1 NLRP10 IGHMBP2 ATP6V0A4 ATP1A1 ATP1A2 ATP1A3 POLQ ABCB1	9.65e-05	614	61	9	GO:0140657
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	SLC6A1 CACNG6 TRPM5 PKD1L1 ATP6V0A4 ATP1A1 MAGT1 ATP1A2 ATP1A3	1.13e-04	627	61	9	GO:0022890
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	SLC6A1 CACNG6 TRPM5 PKD1L1 ATP6V0A4 ATP1A1 MAGT1 ATP1A2 ATP1A3	1.74e-04	664	61	9	GO:0008324
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SLC6A1 TRPM5 ATP1A1 ATP1A2 ATP1A3	1.75e-04	171	61	5	GO:0015081
GeneOntologyMolecularFunction	phosphatidylcholine floppase activity	ABCA1 ABCB1	2.54e-04	8	61	2	GO:0090554
GeneOntologyMolecularFunction	phosphatidylinositol-3-phosphate binding	DAB2IP PLA2G4A PARD3	4.25e-04	48	61	3	GO:0032266
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	SLC6A1 CACNG6 TRPM5 PKD1L1 ATP6V0A4 ATP1A1 MAGT1 ATP1A2 ATP1A3	4.61e-04	758	61	9	GO:0015318
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC6A1 ABCA1 ATP6V0A4 ATP1A1 ATP1A2 ATP1A3 ABCB1	6.08e-04	477	61	7	GO:0022804
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	SLC6A1 CACNG6 TRPM5 PKD1L1 ATP6V0A4 ATP1A1 MAGT1 ATP1A2 ATP1A3	6.39e-04	793	61	9	GO:0015075
GeneOntologyMolecularFunction	steroid binding	ABCA1 ATP1A1 ATP1A2 ATP1A3	7.32e-04	133	61	4	GO:0005496
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC6A1 ABCA1 CACNG6 TRPM5 PKD1L1 ATP6V0A4 ATP1A1 MAGT1 ATP1A2 ATP1A3 ABCB1	8.00e-04	1180	61	11	GO:0022857
GeneOntologyMolecularFunction	potassium ion binding	ATP1A1 ATP1A2	8.16e-04	14	61	2	GO:0030955
GeneOntologyMolecularFunction	D1 dopamine receptor binding	PTPN11 ATP1A3	8.16e-04	14	61	2	GO:0031748
GeneOntologyMolecularFunction	sodium ion binding	ATP1A1 ATP1A2	8.16e-04	14	61	2	GO:0031402
GeneOntologyMolecularFunction	insulin receptor substrate binding	JAK2 PTPN11	9.40e-04	15	61	2	GO:0043560
GeneOntologyMolecularFunction	floppase activity	ABCA1 ABCB1	1.07e-03	16	61	2	GO:0140328
GeneOntologyMolecularFunction	mitogen-activated protein kinase kinase binding	DAB2IP ACE	1.52e-03	19	61	2	GO:0031434
GeneOntologyMolecularFunction	transporter activity	SLC6A1 ABCA1 CACNG6 TRPM5 PKD1L1 ATP6V0A4 ATP1A1 MAGT1 ATP1A2 ATP1A3 ABCB1	1.64e-03	1289	61	11	GO:0005215
GeneOntologyMolecularFunction	phosphatidylcholine transporter activity	ABCA1 ABCB1	1.68e-03	20	61	2	GO:0008525
GeneOntologyMolecularFunction	sphingolipid transporter activity	ABCA1 ABCB1	1.68e-03	20	61	2	GO:0046624
GeneOntologyMolecularFunction	potassium ion transmembrane transporter activity	TRPM5 ATP1A1 ATP1A2 ATP1A3	1.70e-03	167	61	4	GO:0015079
GeneOntologyMolecularFunction	peptide hormone receptor binding	JAK2 PTPN11	1.86e-03	21	61	2	GO:0051428
GeneOntologyMolecularFunction	ankyrin binding	SPTB ATP1A1	2.23e-03	23	61	2	GO:0030506
GeneOntologyMolecularFunction	active monoatomic ion transmembrane transporter activity	SLC6A1 ATP6V0A4 ATP1A1 ATP1A2 ATP1A3	2.25e-03	301	61	5	GO:0022853
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	ABCA1 NLRP10 IGHMBP2 ATP1A1 ATP1A2 ATP1A3 POLQ ABCB1	2.37e-03	775	61	8	GO:0017111
GeneOntologyMolecularFunction	dopamine receptor binding	PTPN11 ATP1A3	2.85e-03	26	61	2	GO:0050780
GeneOntologyMolecularFunction	alkali metal ion binding	ATP1A1 ATP1A2	2.85e-03	26	61	2	GO:0031420
GeneOntologyMolecularFunction	ATPase-coupled intramembrane lipid transporter activity	ABCA1 ABCB1	3.30e-03	28	61	2	GO:0140326
GeneOntologyMolecularFunction	insulin receptor binding	PTPN11 IRS1	3.78e-03	30	61	2	GO:0005158
GeneOntologyMolecularFunction	pyrophosphatase activity	ABCA1 NLRP10 IGHMBP2 ATP1A1 ATP1A2 ATP1A3 POLQ ABCB1	3.85e-03	839	61	8	GO:0016462
GeneOntologyMolecularFunction	hormone binding	ATP1A1 ATP1A2 ATP1A3	3.86e-03	103	61	3	GO:0042562
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	ABCA1 NLRP10 IGHMBP2 ATP1A1 ATP1A2 ATP1A3 POLQ ABCB1	3.88e-03	840	61	8	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	ABCA1 NLRP10 IGHMBP2 ATP1A1 ATP1A2 ATP1A3 POLQ ABCB1	3.88e-03	840	61	8	GO:0016818
GeneOntologyMolecularFunction	hormone receptor binding	JAK2 PTPN11	4.84e-03	34	61	2	GO:0051427
GeneOntologyMolecularFunction	phosphatidylinositol-4-phosphate binding	DAB2IP PLA2G4A	5.41e-03	36	61	2	GO:0070273
GeneOntologyMolecularFunction	calcium channel activity	CACNG6 TRPM5 PKD1L1	7.22e-03	129	61	3	GO:0005262
GeneOntologyMolecularFunction	signaling adaptor activity	DAB2IP PTPN11 IRS1	7.22e-03	129	61	3	GO:0035591
GeneOntologyMolecularFunction	14-3-3 protein binding	DAB2IP TBC1D22A	7.31e-03	42	61	2	GO:0071889
GeneOntologyBiologicalProcess	response to glycoside	ATP1A1 ATP1A2 ATP1A3	2.45e-07	5	61	3	GO:1903416
GeneOntologyBiologicalProcess	establishment or maintenance of transmembrane electrochemical gradient	ATP1A1 ATP1A2 ATP1A3	3.99e-06	11	61	3	GO:0010248
GeneOntologyBiologicalProcess	export across plasma membrane	ABCA1 ATP1A1 ATP1A2 ATP1A3 ABCB1	7.32e-06	91	61	5	GO:0140115
GeneOntologyBiologicalProcess	intracellular potassium ion homeostasis	ATP1A1 ATP1A2 ATP1A3	1.62e-05	17	61	3	GO:0030007
GeneOntologyBiologicalProcess	sodium ion export across plasma membrane	ATP1A1 ATP1A2 ATP1A3	1.62e-05	17	61	3	GO:0036376
GeneOntologyBiologicalProcess	cell communication by electrical coupling involved in cardiac conduction	ATP1A1 ATP1A2 ATP1A3	6.10e-05	26	61	3	GO:0086064
GeneOntologyBiologicalProcess	sphingolipid translocation	ABCA1 ABCB1	8.55e-05	5	61	2	GO:0099039
GeneOntologyBiologicalProcess	intracellular sodium ion homeostasis	ATP1A1 ATP1A2 ATP1A3	9.44e-05	30	61	3	GO:0006883
GeneOntologyBiologicalProcess	export from cell	JAK2 ABCA1 PTPN11 MAOB PLA2G4A IRS1 ATP1A1 ATP1A2 ATP1A3 GRM8 ALOX5 ABCB1	1.20e-04	1153	61	12	GO:0140352
GeneOntologyBiologicalProcess	corpus callosum development	DMXL2 SZT2 CORO1C	1.26e-04	33	61	3	GO:0022038
GeneOntologyBiologicalProcess	cell communication by electrical coupling	ATP1A1 ATP1A2 ATP1A3	1.51e-04	35	61	3	GO:0010644
GeneOntologyBiologicalProcess	central nervous system development	DAB2IP SOX12 DMXL2 BRINP3 PTPN11 MAOB SZT2 CORO1C IGHMBP2 ATP1A2 ATP1A3 ABCB1	1.71e-04	1197	61	12	GO:0007417
GeneOntologyBiologicalProcess	potassium ion homeostasis	ATP1A1 ATP1A2 ATP1A3	1.78e-04	37	61	3	GO:0055075
GeneOntologyBiologicalProcess	cardiac conduction	ATP1A1 ATP1A2 ATP1A3 ACE	2.20e-04	100	61	4	GO:0061337
GeneOntologyBiologicalProcess	chemical homeostasis	DMXL2 ABCA1 PTPN11 FRRS1 ATP6V0A4 PLA2G4A IRS1 ATP1A1 ATP1A2 ATP1A3 ACE ALOX5	2.53e-04	1249	61	12	GO:0048878
GeneOntologyBiologicalProcess	cellular response to lipid	DAB2IP JAK2 BRINP3 ABCA1 IRS1 ATP1A1 ATP1A2 ATP1A3 ACE	3.31e-04	748	61	9	GO:0071396
GeneOntologyBiologicalProcess	sodium ion transmembrane transport	SLC6A1 TRPM5 ATP1A1 ATP1A2 ATP1A3	3.74e-04	208	61	5	GO:0035725
GeneOntologyBiologicalProcess	amino acid neurotransmitter reuptake	SLC6A1 ATP1A2	3.81e-04	10	61	2	GO:0051933
GeneOntologyBiologicalProcess	response to lipid	DAB2IP SLC6A1 JAK2 BRINP3 ABCA1 MAOB IRS1 ATP1A1 ATP1A2 ATP1A3 ACE	4.13e-04	1126	61	11	GO:0033993
GeneOntologyBiologicalProcess	telencephalon development	DAB2IP DMXL2 SZT2 CORO1C ATP1A2 ATP1A3	4.38e-04	332	61	6	GO:0021537
GeneOntologyBiologicalProcess	potassium ion import across plasma membrane	ATP1A1 ATP1A2 ATP1A3	4.63e-04	51	61	3	GO:1990573
GeneOntologyBiologicalProcess	sodium ion homeostasis	ATP1A1 ATP1A2 ATP1A3	4.63e-04	51	61	3	GO:0055078
GeneOntologyCellularComponent	plasma membrane raft	JAK2 PTPN11 CORO1C IRS1 ATP1A1 ATP1A2	3.27e-06	147	58	6	GO:0044853
GeneOntologyCellularComponent	sodium:potassium-exchanging ATPase complex	ATP1A1 ATP1A2 ATP1A3	4.38e-06	12	58	3	GO:0005890
GeneOntologyCellularComponent	somatodendritic compartment	DAB2IP SLC6A1 TANC2 BRINP3 TRPM5 MAOB IGHMBP2 CPEB3 ATP1A2 ATP1A3 PARD3 GRM8 ALOX5 PDE11A	4.80e-06	1228	58	14	GO:0036477
GeneOntologyCellularComponent	cation-transporting ATPase complex	ATP6V0A4 ATP1A1 ATP1A2 ATP1A3	1.03e-05	49	58	4	GO:0090533
GeneOntologyCellularComponent	caveola	JAK2 CORO1C IRS1 ATP1A1 ATP1A2	1.41e-05	111	58	5	GO:0005901
GeneOntologyCellularComponent	sarcolemma	CACNG6 CORO1C ATP1A1 ATP1A2 ATP1A3 ALOX5	1.42e-05	190	58	6	GO:0042383
GeneOntologyCellularComponent	neuronal cell body	DAB2IP SLC6A1 BRINP3 TRPM5 MAOB IGHMBP2 ATP1A2 ATP1A3 PARD3 GRM8 PDE11A	1.58e-05	835	58	11	GO:0043025
GeneOntologyCellularComponent	ATPase dependent transmembrane transport complex	ATP6V0A4 ATP1A1 ATP1A2 ATP1A3	1.64e-05	55	58	4	GO:0098533
GeneOntologyCellularComponent	cell body	DAB2IP SLC6A1 BRINP3 TRPM5 MAOB IGHMBP2 ATP1A2 ATP1A3 PARD3 GRM8 PDE11A	4.21e-05	929	58	11	GO:0044297
GeneOntologyCellularComponent	photoreceptor inner segment membrane	ATP1A1 ATP1A3	4.52e-05	4	58	2	GO:0060342
GeneOntologyCellularComponent	membrane raft	JAK2 ABCA1 PTPN11 CORO1C IRS1 ATP1A1 ATP1A2	6.20e-05	362	58	7	GO:0045121
GeneOntologyCellularComponent	membrane microdomain	JAK2 ABCA1 PTPN11 CORO1C IRS1 ATP1A1 ATP1A2	6.42e-05	364	58	7	GO:0098857
GeneOntologyCellularComponent	GATOR2 complex	SZT2 WDR24	4.91e-04	12	58	2	GO:0061700
GeneOntologyCellularComponent	dendrite	DAB2IP TANC2 BRINP3 TRPM5 MAOB CPEB3 ATP1A2 ATP1A3 ALOX5	5.54e-04	858	58	9	GO:0030425
GeneOntologyCellularComponent	dendritic tree	DAB2IP TANC2 BRINP3 TRPM5 MAOB CPEB3 ATP1A2 ATP1A3 ALOX5	5.64e-04	860	58	9	GO:0097447
GeneOntologyCellularComponent	transmembrane transporter complex	CACNG6 TRPM5 PKD1L1 ATP6V0A4 ATP1A1 ATP1A2 ATP1A3	5.88e-04	523	58	7	GO:1902495
GeneOntologyCellularComponent	membrane protein complex	JAK2 CACNG6 TRPM5 CORO1C PKD1L1 ATP6V0A4 IRS1 ATP1A1 MAGT1 ATP1A2 ATP1A3 SEC31B	7.13e-04	1498	58	12	GO:0098796
GeneOntologyCellularComponent	transporter complex	CACNG6 TRPM5 PKD1L1 ATP6V0A4 ATP1A1 ATP1A2 ATP1A3	7.91e-04	550	58	7	GO:1990351
GeneOntologyCellularComponent	Seh1-associated complex	SZT2 WDR24	8.86e-04	16	58	2	GO:0035859
GeneOntologyCellularComponent	T-tubule	CACNG6 ATP1A1 ATP1A2	1.38e-03	79	58	3	GO:0030315
GeneOntologyCellularComponent	myelin sheath	ATP1A1 ATP1A2 ATP1A3 PARD3	3.09e-03	217	58	4	GO:0043209
HumanPheno	Episodic quadriplegia	ATP1A2 ATP1A3	2.31e-05	2	25	2	HP:0200072
Domain	P-type_ATPase_IIC	ATP1A1 ATP1A2 ATP1A3	6.26e-07	6	60	3	IPR005775
Domain	-	ATP1A1 ATP1A2 ATP1A3	1.71e-05	16	60	3	1.20.1110.10
Domain	ATPase_P-typ_TM_dom	ATP1A1 ATP1A2 ATP1A3	1.71e-05	16	60	3	IPR023298
Domain	ATPase_P-typ_cation-transptr_C	ATP1A1 ATP1A2 ATP1A3	2.08e-05	17	60	3	IPR006068
Domain	Cation_ATPase_C	ATP1A1 ATP1A2 ATP1A3	2.08e-05	17	60	3	PF00689
Domain	Cation_ATPase_N	ATP1A1 ATP1A2 ATP1A3	2.49e-05	18	60	3	PF00690
Domain	Cation_ATPase_N	ATP1A1 ATP1A2 ATP1A3	2.49e-05	18	60	3	SM00831
Domain	ATPase_P-typ_cation-transptr_N	ATP1A1 ATP1A2 ATP1A3	2.94e-05	19	60	3	IPR004014
Domain	NUT	NUTM2F NUTM2G	1.01e-04	5	60	2	IPR024310
Domain	NUT_N	NUTM2F NUTM2G	1.01e-04	5	60	2	IPR024309
Domain	NUT	NUTM2F NUTM2G	1.01e-04	5	60	2	PF12881
Domain	-	ATP1A1 ATP1A2 ATP1A3	1.46e-04	32	60	3	3.40.1110.10
Domain	-	ATP1A1 ATP1A2 ATP1A3	1.46e-04	32	60	3	2.70.150.10
Domain	ATPase_P-typ_cyto_domN	ATP1A1 ATP1A2 ATP1A3	1.92e-04	35	60	3	IPR023299
Domain	P_typ_ATPase	ATP1A1 ATP1A2 ATP1A3	2.09e-04	36	60	3	IPR001757
Domain	ATPase_P-typ_P_site	ATP1A1 ATP1A2 ATP1A3	2.09e-04	36	60	3	IPR018303
Domain	ATPASE_E1_E2	ATP1A1 ATP1A2 ATP1A3	2.09e-04	36	60	3	PS00154
Domain	ATPase_P-typ_transduc_dom_A	ATP1A1 ATP1A2 ATP1A3	2.27e-04	37	60	3	IPR008250
Domain	E1-E2_ATPase	ATP1A1 ATP1A2 ATP1A3	2.27e-04	37	60	3	PF00122
Domain	LH2	PKD1L1 ALOX5	1.50e-03	18	60	2	SM00308
Domain	PLAT	PKD1L1 ALOX5	2.05e-03	21	60	2	PS50095
Domain	-	PKD1L1 ALOX5	2.05e-03	21	60	2	2.60.60.20
Domain	PLAT	PKD1L1 ALOX5	2.05e-03	21	60	2	PF01477
Domain	PLAT/LH2_dom	PKD1L1 ALOX5	2.05e-03	21	60	2	IPR001024
Domain	HAD-like_dom	ATP1A1 ATP1A2 ATP1A3	2.10e-03	79	60	3	IPR023214
Domain	ABC_transporter_CS	ABCA1 ABCB1	8.05e-03	42	60	2	IPR017871
Domain	WD40	DMXL2 CORO1C SEC31B WDR24	9.60e-03	259	60	4	PF00400
Domain	-	EXD2 POLQ	1.00e-02	47	60	2	3.30.420.10
Domain	ABC_tran	ABCA1 ABCB1	1.04e-02	48	60	2	PF00005
Domain	ABC_TRANSPORTER_2	ABCA1 ABCB1	1.04e-02	48	60	2	PS50893
Domain	WD40	DMXL2 CORO1C SEC31B WDR24	1.08e-02	268	60	4	SM00320
Domain	ABC_TRANSPORTER_1	ABCA1 ABCB1	1.08e-02	49	60	2	PS00211
Domain	AAA+_ATPase	ABCA1 IGHMBP2 ABCB1	1.11e-02	144	60	3	IPR003593
Domain	AAA	ABCA1 IGHMBP2 ABCB1	1.11e-02	144	60	3	SM00382
Domain	ABC_transporter-like	ABCA1 ABCB1	1.13e-02	50	60	2	IPR003439
Domain	WD40_repeat	DMXL2 CORO1C SEC31B WDR24	1.13e-02	272	60	4	IPR001680
Domain	WD_REPEATS_1	DMXL2 CORO1C SEC31B WDR24	1.22e-02	278	60	4	PS00678
Domain	WD_REPEATS_2	DMXL2 CORO1C SEC31B WDR24	1.23e-02	279	60	4	PS50082
Domain	WD_REPEATS_REGION	DMXL2 CORO1C SEC31B WDR24	1.23e-02	279	60	4	PS50294
Pathway	REACTOME_SIGNALING_BY_LEPTIN	JAK2 PTPN11 IRS1	4.93e-06	11	45	3	M27195
Pathway	KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION	IRS1 ATP1A1 ATP1A2 ATP1A3	9.28e-06	42	45	4	M16473
Pathway	KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION	ATP1A1 ATP1A2 ATP1A3	5.15e-05	23	45	3	M4361
Pathway	WP_IL5_SIGNALING_PATHWAY	JAK2 PTPN11 PLA2G4A ALOX5	6.36e-05	68	45	4	MM15930
Pathway	WP_UROTENSINIIMEDIATED_SIGNALING	JAK2 ABCA1 PTPN11 ALOX5	6.73e-05	69	45	4	M48052
Pathway	KEGG_CARDIAC_MUSCLE_CONTRACTION	CACNG6 ATP1A1 ATP1A2 ATP1A3	1.14e-04	79	45	4	M17673
Pathway	REACTOME_ION_CHANNEL_TRANSPORT	TRPM5 ATP6V0A4 ATP1A1 ATP1A2 ATP1A3	2.34e-04	176	45	5	MM15718
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	SLC6A1 ABCA1 TRPM5 ATP6V0A4 ATP1A1 MAGT1 ATP1A2 ATP1A3 ABCB1	2.52e-04	681	45	9	MM14985
Pathway	REACTOME_MAPK1_ERK2_ACTIVATION	JAK2 PTPN11	2.76e-04	8	45	2	MM14507
Pathway	REACTOME_ION_CHANNEL_TRANSPORT	TRPM5 ATP6V0A4 ATP1A1 ATP1A2 ATP1A3	2.80e-04	183	45	5	M997
Pathway	REACTOME_CARDIAC_CONDUCTION	CACNG6 ATP1A1 ATP1A2 ATP1A3	3.18e-04	103	45	4	MM15196
Pathway	REACTOME_MAPK3_ERK1_ACTIVATION	JAK2 PTPN11	3.54e-04	9	45	2	MM14474
Pathway	REACTOME_INTERLEUKIN_6_SIGNALING	JAK2 PTPN11	3.54e-04	9	45	2	MM14470
Pathway	REACTOME_MAPK1_ERK2_ACTIVATION	JAK2 PTPN11	3.54e-04	9	45	2	M26918
Pathway	REACTOME_MAPK3_ERK1_ACTIVATION	JAK2 PTPN11	4.41e-04	10	45	2	M26896
Pathway	WP_EICOSANOID_LIPID_SYNTHESIS_MAP	PLA2G4A ALOX5	4.41e-04	10	45	2	MM15916
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	SLC6A1 ABCA1 TRPM5 ATP6V0A4 ATP1A1 MAGT1 ATP1A2 ATP1A3 ABCB1	4.47e-04	736	45	9	M27287
Pathway	REACTOME_INTERLEUKIN_6_SIGNALING	JAK2 PTPN11	5.38e-04	11	45	2	M1014
Pathway	WP_IL4_SIGNALING	JAK2 PTPN11 IRS1	6.73e-04	54	45	3	M39720
Pathway	REACTOME_ION_HOMEOSTASIS	ATP1A1 ATP1A2 ATP1A3	6.73e-04	54	45	3	M27460
Pathway	REACTOME_ION_HOMEOSTASIS	ATP1A1 ATP1A2 ATP1A3	6.73e-04	54	45	3	MM15202
Pathway	REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES	ATP1A1 ATP1A2 ATP1A3	7.10e-04	55	45	3	M971
Pathway	REACTOME_CARDIAC_CONDUCTION	CACNG6 ATP1A1 ATP1A2 ATP1A3	7.68e-04	130	45	4	M27454
Pathway	PID_SHP2_PATHWAY	JAK2 PTPN11 IRS1	7.88e-04	57	45	3	M100
Pathway	WP_PROXIMAL_TUBULE_TRANSPORT	ATP6V0A4 ATP1A1 ABCB1	7.88e-04	57	45	3	M39812
Pathway	REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES	ATP1A1 ATP1A2 ATP1A3	7.88e-04	57	45	3	MM15643
Pathway	PID_IL5_PATHWAY	JAK2 PTPN11	8.85e-04	14	45	2	M135
Pathway	REACTOME_REGULATION_OF_IFNG_SIGNALING	JAK2 PTPN11	8.85e-04	14	45	2	M942
Pathway	REACTOME_PROLACTIN_RECEPTOR_SIGNALING	JAK2 PTPN11	1.02e-03	15	45	2	M552
Pathway	WP_ONCOSTATIN_M_SIGNALING	JAK2 PTPN11 IRS1	1.16e-03	65	45	3	M39562
Pathway	WP_AGERAGE_PATHWAY	JAK2 PLA2G4A IRS1	1.21e-03	66	45	3	M39420
Pathway	KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY	JAK2 PTPN11 IRS1	1.26e-03	67	45	3	M10462
Pathway	REACTOME_PLATELET_SENSITIZATION_BY_LDL	PTPN11 PLA2G4A	1.31e-03	17	45	2	MM15096
Pathway	WP_LEPTININSULIN_SIGNALING_OVERLAP	JAK2 IRS1	1.31e-03	17	45	2	M39517
Pathway	REACTOME_PLATELET_SENSITIZATION_BY_LDL	PTPN11 PLA2G4A	1.31e-03	17	45	2	M919
Pathway	REACTOME_POTENTIAL_THERAPEUTICS_FOR_SARS	JAK2 ATP1A1 ATP1A2 ATP1A3	1.44e-03	154	45	4	M39007
Pathway	PID_AVB3_INTEGRIN_PATHWAY	PTPN11 COL15A1 IRS1	1.68e-03	74	45	3	M160
Pathway	REACTOME_PLATELET_HOMEOSTASIS	PTPN11 PLA2G4A PDE11A	1.82e-03	76	45	3	MM15051
Pathway	WP_LEPTIN_SIGNALING	JAK2 PTPN11 IRS1	1.82e-03	76	45	3	M39491
Pathway	WP_PROLACTIN_SIGNALING	JAK2 PTPN11 IRS1	1.82e-03	76	45	3	M39601
Pathway	BIOCARTA_EICOSANOID_PATHWAY	PLA2G4A ALOX5	1.83e-03	20	45	2	MM1529
Pathway	REACTOME_INTERLEUKIN_20_FAMILY_SIGNALING	JAK2 PTPN11	1.83e-03	20	45	2	MM15496
Pathway	WP_LEPTININSULIN_SIGNALING_OVERLAP	JAK2 IRS1	1.83e-03	20	45	2	MM15867
Pathway	WP_LIPID_METABOLISM_IN_SENESCENT_CELLS	PLA2G4A ALOX5	1.83e-03	20	45	2	M45542
Pathway	REACTOME_MUSCLE_CONTRACTION	CACNG6 ATP1A1 ATP1A2 ATP1A3	1.86e-03	165	45	4	MM15026
Pathway	BIOCARTA_IGF1_PATHWAY	PTPN11 IRS1	2.01e-03	21	45	2	M2623
Pathway	BIOCARTA_IL6_PATHWAY	JAK2 PTPN11	2.01e-03	21	45	2	M5489
Pathway	BIOCARTA_INSULIN_PATHWAY	PTPN11 IRS1	2.01e-03	21	45	2	M765
Pathway	REACTOME_INTERLEUKIN_6_FAMILY_SIGNALING	JAK2 PTPN11	2.21e-03	22	45	2	MM15319
Pathway	BIOCARTA_IGF1_PATHWAY	PTPN11 IRS1	2.21e-03	22	45	2	MM1409
Pathway	BIOCARTA_IL6_PATHWAY	JAK2 PTPN11	2.21e-03	22	45	2	MM1415
Pathway	REACTOME_SIGNALING_BY_CSF3_G_CSF	JAK2 PTPN11	2.21e-03	22	45	2	MM15675
Pathway	REACTOME_RAF_INDEPENDENT_MAPK1_3_ACTIVATION	JAK2 PTPN11	2.21e-03	22	45	2	MM14506
Pathway	BIOCARTA_EICOSANOID_PATHWAY	PLA2G4A ALOX5	2.21e-03	22	45	2	M22003
Pathway	REACTOME_SIGNALING_BY_INSULIN_RECEPTOR	PTPN11 ATP6V0A4 IRS1	2.26e-03	82	45	3	M1021
Pathway	REACTOME_RAF_INDEPENDENT_MAPK1_3_ACTIVATION	JAK2 PTPN11	2.42e-03	23	45	2	M26917
Pathway	WP_EICOSANOID_SYNTHESIS	PLA2G4A ALOX5	2.42e-03	23	45	2	M39382
Pathway	REACTOME_PLATELET_HOMEOSTASIS	PTPN11 PLA2G4A PDE11A	2.59e-03	86	45	3	M916
Pathway	REACTOME_INTERLEUKIN_6_FAMILY_SIGNALING	JAK2 PTPN11	2.63e-03	24	45	2	M27604
Pathway	BIOCARTA_INSULIN_PATHWAY	PTPN11 IRS1	2.63e-03	24	45	2	MM1425
Pathway	REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING	JAK2 IRS1	2.63e-03	24	45	2	M519
Pathway	WP_IL2_SIGNALING_PATHWAY	JAK2 PTPN11 IRS1	2.67e-03	87	45	3	MM15915
Pathway	REACTOME_INTERLEUKIN_20_FAMILY_SIGNALING	JAK2 PTPN11	3.08e-03	26	45	2	M27750
Pathway	WP_EPO_RECEPTOR_SIGNALING	JAK2 IRS1	3.08e-03	26	45	2	M39687
Pathway	PID_IL3_PATHWAY	JAK2 PTPN11	3.08e-03	26	45	2	M182
Pathway	WP_EPO_RECEPTOR_SIGNALING	JAK2 IRS1	3.08e-03	26	45	2	MM15896
Pathway	BIOCARTA_GH_PATHWAY	JAK2 IRS1	3.32e-03	27	45	2	M9043
Pathway	REACTOME_SARS_COV_INFECTIONS	JAK2 PTPN11 ATP1A1 MAGT1 ATP1A2 ATP1A3	3.63e-03	471	45	6	M39009
Pathway	REACTOME_MAPK_FAMILY_SIGNALING_CASCADES	DAB2IP JAK2 PTPN11 SPTB IRS1	3.72e-03	327	45	5	M27565
Pathway	PID_IGF1_PATHWAY	PTPN11 IRS1	3.83e-03	29	45	2	M125
Pathway	REACTOME_MUSCLE_CONTRACTION	CACNG6 ATP1A1 ATP1A2 ATP1A3	3.92e-03	203	45	4	M5485
Pathway	REACTOME_SIGNALING_BY_CSF3_G_CSF	JAK2 PTPN11	4.09e-03	30	45	2	M41825
Pathway	WP_NUCLEAR_RECEPTORS_IN_LIPID_METABOLISM_AND_TOXICITY	ABCA1 ABCB1	4.09e-03	30	45	2	MM15866
Pubmed	Three differentially expressed Na,K-ATPase alpha subunit isoforms: structural and functional implications.	ATP1A1 ATP1A2 ATP1A3	5.13e-09	3	61	3	2822726
Pubmed	Differential expression of Na+/K+-ATPase alpha-subunits in mouse hippocampal interneurones and pyramidal cells.	ATP1A1 ATP1A2 ATP1A3	5.13e-09	3	61	3	17947306
Pubmed	Knockout of sodium pump α3 subunit gene (Atp1a3-/-) results in perinatal seizure and defective respiratory rhythm generation.	ATP1A1 ATP1A2 ATP1A3	5.13e-09	3	61	3	28465228
Pubmed	Na,K-ATPase and the role of alpha isoforms in behavior.	ATP1A1 ATP1A2 ATP1A3	5.13e-09	3	61	3	18044013
Pubmed	Na+/K+-ATPase α isoform deficiency results in distinct spreading depolarization phenotypes.	ATP1A1 ATP1A2 ATP1A3	5.13e-09	3	61	3	30819023
Pubmed	Association between sodium- and potassium-activated adenosine triphosphatase alpha isoforms and bipolar disorders.	ATP1A1 ATP1A2 ATP1A3	5.13e-09	3	61	3	19058785
Pubmed	Developmental cell-specific regulation of Na(+)-K(+)-ATPase alpha 1-, alpha 2-, and alpha 3-isoform gene expression.	ATP1A1 ATP1A2 ATP1A3	5.13e-09	3	61	3	8203495
Pubmed	Glutamate-system defects behind psychiatric manifestations in a familial hemiplegic migraine type 2 disease-mutation mouse model.	ATP1A1 ATP1A2 ATP1A3	5.13e-09	3	61	3	26911348
Pubmed	Cardiac glycosides induced toxicity in human cells expressing α1-, α2-, or α3-isoforms of Na-K-ATPase.	ATP1A1 ATP1A2 ATP1A3	5.13e-09	3	61	3	25994790
Pubmed	Increased susceptibility to cortical spreading depression in the mouse model of familial hemiplegic migraine type 2.	ATP1A1 ATP1A2 ATP1A3	2.05e-08	4	61	3	21731499
Pubmed	The Na,K-ATPase alpha 2 isoform is expressed in neurons, and its absence disrupts neuronal activity in newborn mice.	ATP1A1 ATP1A2 ATP1A3	2.05e-08	4	61	3	12458206
Pubmed	Preactivation of AMPK by metformin may ameliorate the epithelial cell damage caused by renal ischemia.	ATP1A1 ATP1A2 ATP1A3	2.05e-08	4	61	3	21849490
Pubmed	Muscle Na+-K+-ATPase activity and isoform adaptations to intense interval exercise and training in well-trained athletes.	ATP1A1 ATP1A2 ATP1A3	2.05e-08	4	61	3	17446412
Pubmed	Isoform specificity of cardiac glycosides binding to human Na+,K+-ATPase alpha1beta1, alpha2beta1 and alpha3beta1.	ATP1A1 ATP1A2 ATP1A3	2.05e-08	4	61	3	19751721
Pubmed	Agrin regulation of alpha3 sodium-potassium ATPase activity modulates cardiac myocyte contraction.	ATP1A1 ATP1A2 ATP1A3	2.05e-08	4	61	3	19376779
Pubmed	Deficiency in Na,K-ATPase alpha isoform genes alters spatial learning, motor activity, and anxiety in mice.	ATP1A1 ATP1A2 ATP1A3	2.05e-08	4	61	3	17234593
Pubmed	Multiple genes encode the human Na+,K+-ATPase catalytic subunit.	ATP1A1 ATP1A2 ATP1A3	5.12e-08	5	61	3	3035563
Pubmed	The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit.	ATP1A1 ATP1A2 ATP1A3	1.02e-07	6	61	3	3036582
Pubmed	Transport and pharmacological properties of nine different human Na, K-ATPase isozymes.	ATP1A1 ATP1A2 ATP1A3	1.02e-07	6	61	3	10636900
Pubmed	Differential involvement of Na(+),K(+)-ATPase isozymes in preimplantation development of the mouse.	ATP1A1 ATP1A2 ATP1A3	1.79e-07	7	61	3	10837135
Pubmed	Molecular genetics of Na,K-ATPase.	ATP1A1 ATP1A2 ATP1A3	1.79e-07	7	61	3	2158121
Pubmed	Expression and distribution of Na, K-ATPase isoforms in the human uterus.	ATP1A1 ATP1A2 ATP1A3	1.79e-07	7	61	3	20065300
Pubmed	Dysfunction of ouabain-induced cardiac contractility in mice with heart-specific ablation of Na,K-ATPase beta1-subunit.	ATP1A1 ATP1A2 ATP1A3	2.86e-07	8	61	3	19683723
Pubmed	Genes encoding alpha and beta subunits of Na,K-ATPase are located on three different chromosomes in the mouse.	ATP1A1 ATP1A2 ATP1A3	2.86e-07	8	61	3	2885848
Pubmed	Enhanced inhibitory neurotransmission in the cerebellar cortex of Atp1a3-deficient heterozygous mice.	ATP1A1 ATP1A2 ATP1A3	2.86e-07	8	61	3	23652595
Pubmed	The Na(+)-K(+)-ATPase alpha2-subunit isoform modulates contractility in the perinatal mouse diaphragm.	ATP1A1 ATP1A2 ATP1A3	4.28e-07	9	61	3	15253893
Pubmed	Retinal pigment epithelial integrity is compromised in the developing albino mouse retina.	ATP1A1 ATP1A2 ATP1A3	1.12e-06	12	61	3	27097562
Pubmed	Chromosomal assignments of 17 structural genes and 11 related DNA fragments in rats (Rattus norvegicus) by Southern blot analysis of rat x mouse somatic cell hybrid clones.	ATP1A1 ATP1A2 ATP1A3	1.84e-06	14	61	3	1572638
Pubmed	Decreased expression of both the alpha1- and alpha2-subunits of the Na-K-ATPase reduces maximal alveolar epithelial fluid clearance.	ATP1A1 ATP1A2	3.03e-06	2	61	2	15781423
Pubmed	Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1.	PTPN11 IRS1	3.03e-06	2	61	2	7513703
Pubmed	The COOH-terminal tyrosine phosphorylation sites on IRS-1 bind SHP-2 and negatively regulate insulin signaling.	PTPN11 IRS1	3.03e-06	2	61	2	9756938
Pubmed	Association of the ACE I/D gene polymorphisms with JAK2V617F-positive polycythemia vera and essential thrombocythemia.	JAK2 ACE	3.03e-06	2	61	2	25955555
Pubmed	Arachidonic acid metabolism regulates Escherichia coli penetration of the blood-brain barrier.	PLA2G4A ALOX5	3.03e-06	2	61	2	20696828
Pubmed	Molecular cloning of the mouse ouabain-resistance gene.	ATP1A1 ATP1A2	3.03e-06	2	61	2	6324196
Pubmed	Energy-sensitive regulation of Na+/K+-ATPase by Janus kinase 2.	JAK2 ATP1A1	3.03e-06	2	61	2	24304834
Pubmed	Malaria in pregnancy regulates P-glycoprotein (P-gp/Abcb1a) and ABCA1 efflux transporters in the Mouse Visceral Yolk Sac.	ABCA1 ABCB1	3.03e-06	2	61	2	32779889
Pubmed	Hypoxia inhibits JAK2V617F activation via suppression of SHP-2 function in myeloproliferative neoplasm cells.	JAK2 PTPN11	3.03e-06	2	61	2	24860972
Pubmed	The alpha(1)- and alpha(2)-isoforms of Na-K-ATPase play different roles in skeletal muscle contractility.	ATP1A1 ATP1A2	3.03e-06	2	61	2	11507009
Pubmed	The structure of the Na+,K+-ATPase and mapping of isoform differences and disease-related mutations.	ATP1A2 ATP1A3	3.03e-06	2	61	2	18957371
Pubmed	All human Na(+)-K(+)-ATPase alpha-subunit isoforms have a similar affinity for cardiac glycosides.	ATP1A1 ATP1A3	3.03e-06	2	61	2	11546672
Pubmed	Properties and expression of Na+/K+-ATPase α-subunit isoforms in the brain of the swamp eel, Monopterus albus, which has unusually high brain ammonia tolerance.	ATP1A1 ATP1A3	3.03e-06	2	61	2	24391932
Pubmed	Na+/K+ ATPase α1 and α3 isoforms are differentially expressed in α- and γ-motoneurons.	ATP1A1 ATP1A3	3.03e-06	2	61	2	23761886
Pubmed	Ion pumps in polarized cells: sorting and regulation of the Na+, K+- and H+, K+-ATPases.	ATP1A1 ATP1A2	3.03e-06	2	61	2	11404365
Pubmed	Mice expressing ouabain-sensitive α1-Na,K-ATPase have increased susceptibility to pressure overload-induced cardiac hypertrophy.	ATP1A1 ATP1A2	3.03e-06	2	61	2	20952666
Pubmed	The family of human Na+,K+-ATPase genes. A partial nucleotide sequence related to the alpha-subunit.	ATP1A1 ATP1A3	3.03e-06	2	61	2	3030810
Pubmed	ABCA1/ABCB1 Ratio Determines Chemo- and Immune-Sensitivity in Human Osteosarcoma.	ABCA1 ABCB1	3.03e-06	2	61	2	32155954
Pubmed	Expression of alpha isoforms of the Na,K-ATPase in human heart.	ATP1A1 ATP1A2	3.03e-06	2	61	2	8391840
Pubmed	Syp associates with gp130 and Janus kinase 2 in response to interleukin-11 in 3T3-L1 mouse preadipocytes.	JAK2 PTPN11	3.03e-06	2	61	2	7559603
Pubmed	Immunohistochemical analyses of alpha1 and alpha3 Na+/K+-ATPase subunit expression in medulloblastomas.	ATP1A1 ATP1A3	3.03e-06	2	61	2	21498719
Pubmed	ABC proteins protect the human body and maintain optimal health.	ABCA1 ABCB1	3.03e-06	2	61	2	21389634
Pubmed	Marinobufagenin enhances cardiac contractility in mice with ouabain-sensitive alpha1 Na+-K+-ATPase.	ATP1A1 ATP1A2	3.03e-06	2	61	2	19376809
Pubmed	A real-time PCR method to genotype mutant mouse models with altered affinity for cardiotonic steroids on the Na,K-ATPase.	ATP1A1 ATP1A2	3.03e-06	2	61	2	35446892
Pubmed	The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp.	PTPN11 IRS1	3.03e-06	2	61	2	8505282
Pubmed	New molecular determinants controlling the accessibility of ouabain to its binding site in human Na,K-ATPase alpha isoforms.	ATP1A1 ATP1A2	3.03e-06	2	61	2	14742675
Pubmed	ATP1A2- and ATP1A3-associated early profound epileptic encephalopathy and polymicrogyria.	ATP1A2 ATP1A3	3.03e-06	2	61	2	33880529
Pubmed	DOCA-salt hypertension does not require the ouabain-sensitive binding site of the α2 Na,K-ATPase.	ATP1A1 ATP1A2	3.03e-06	2	61	2	22258333
Pubmed	Na(+)/K)+)-ATPase α2-isoform preferentially modulates Ca2(+) transients and sarcoplasmic reticulum Ca2(+) release in cardiac myocytes.	ATP1A1 ATP1A2	3.03e-06	2	61	2	22739122
Pubmed	Identification of a specific role for the Na,K-ATPase alpha 2 isoform as a regulator of calcium in the heart.	ATP1A1 ATP1A2	3.03e-06	2	61	2	10360172
Pubmed	ABCA1 Is Coordinated with ABCB1 in the Arsenic-Resistance of Human Cells.	ABCA1 ABCB1	3.03e-06	2	61	2	29951962
Pubmed	Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation.	PTPN11 IRS1	3.03e-06	2	61	2	7935386
Pubmed	Association of ACE and MDR1 Gene Polymorphisms with Steroid Resistance in Children with Idiopathic Nephrotic Syndrome.	ACE ABCB1	3.03e-06	2	61	2	26154535
Pubmed	Association of the ATP-binding cassette transporter A1 R230C variant with early-onset type 2 diabetes in a Mexican population.	ABCA1 ABCB1	3.03e-06	2	61	2	18003760
Pubmed	Ouabain-Sensitive alpha1 Na,K-ATPase enhances natriuretic response to saline load.	ATP1A1 ATP1A2	3.03e-06	2	61	2	18667729
Pubmed	Renovascular hypertension using a modified two-kidney, one-clip approach in mice is not dependent on the α1 or α2 Na-K-ATPase ouabain-binding site.	ATP1A1 ATP1A2	3.03e-06	2	61	2	21632957
Pubmed	Relationship between intracellular Na+ concentration and reduced Na+ affinity in Na+,K+-ATPase mutants causing neurological disease.	ATP1A2 ATP1A3	3.03e-06	2	61	2	24356962
Pubmed	PGC-1α4 Interacts with REST to Upregulate Neuronal Genes and Augment Energy Consumption in Developing Cardiomyocytes.	ATP1A1 ATP1A2 ATP1A3	3.43e-06	17	61	3	36230906
Pubmed	RNG105 deficiency impairs the dendritic localization of mRNAs for Na+/K+ ATPase subunit isoforms and leads to the degeneration of neuronal networks.	ATP1A1 ATP1A2 ATP1A3	4.88e-06	19	61	3	20861386
Pubmed	Shp2 is required for protein kinase C-dependent phosphorylation of serine 307 in insulin receptor substrate-1.	PTPN11 IRS1	9.07e-06	3	61	2	16055440
Pubmed	Targeted transgenic expression of beta(2)-adrenergic receptors to type II cells increases alveolar fluid clearance.	ATP1A1 ATP1A2	9.07e-06	3	61	2	11557593
Pubmed	Extracellular galectin-3 programs multidrug resistance through Na+/K+-ATPase and P-glycoprotein signaling.	ATP1A1 ABCB1	9.07e-06	3	61	2	26158764
Pubmed	Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation.	JAK2 IRS1	9.07e-06	3	61	2	11208867
Pubmed	Shp2 promotes metastasis of prostate cancer by attenuating the PAR3/PAR6/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition.	PTPN11 PARD3	9.07e-06	3	61	2	26050620
Pubmed	In situ localization of sodium-potassium ATPase mRNA in developing mouse lung epithelium.	ATP1A1 ATP1A2	9.07e-06	3	61	2	7573462
Pubmed	Identification of a VxP Targeting Signal in the Flagellar Na+ /K+ -ATPase.	ATP1A1 ATP1A3	9.07e-06	3	61	2	26373354
Pubmed	ABCA1 mutants reveal an interdependency between lipid export function, apoA-I binding activity, and Janus kinase 2 activation.	JAK2 ABCA1	9.07e-06	3	61	2	18776170
Pubmed	Adapter function of protein-tyrosine phosphatase 1D in insulin receptor/insulin receptor substrate-1 interaction.	PTPN11 IRS1	9.07e-06	3	61	2	7493946
Pubmed	Na,K-ATPase subunit isoforms in human reticulocytes: evidence from reverse transcription-PCR for the presence of alpha1, alpha3, beta2, beta3, and gamma.	ATP1A1 ATP1A2	9.07e-06	3	61	2	9159180
Pubmed	Translationally controlled tumor protein interacts with the third cytoplasmic domain of Na,K-ATPase alpha subunit and inhibits the pump activity in HeLa cells.	ATP1A1 ATP1A2	9.07e-06	3	61	2	15383549
Pubmed	Acquisition of JAK2, PTPN11, and RAS mutations during disease progression in primary myelodysplastic syndrome.	JAK2 PTPN11	9.07e-06	3	61	2	16598312
Pubmed	Roles of the complex formation of SHPS-1 with SHP-2 in insulin-stimulated mitogen-activated protein kinase activation.	PTPN11 IRS1	9.07e-06	3	61	2	9535915
Pubmed	Association of common JAK2 variants with body fat, insulin sensitivity and lipid profile.	JAK2 ABCA1	9.07e-06	3	61	2	18239666
Pubmed	High glucose levels induce inhibition of Na,K-ATPase via stimulation of aldose reductase, formation of microtubules and formation of an acetylated tubulin/Na,K-ATPase complex.	ATP1A1 ATP1A2	9.07e-06	3	61	2	22565168
Pubmed	Glycoprotein nonmetastatic melanoma protein B extracellular fragment shows neuroprotective effects and activates the PI3K/Akt and MEK/ERK pathways via the Na+/K+-ATPase.	ATP1A1 ATP1A3	9.07e-06	3	61	2	26988030
Pubmed	Isoform specificity of the Na/K-ATPase association and regulation by phospholemman.	ATP1A1 ATP1A2	9.07e-06	3	61	2	19638348
Pubmed	Simultaneously reduced NKCC1 and Na,K-ATPase expression in murine cochlear lateral wall contribute to conservation of endocochlear potential following a sensorineural hearing loss.	ATP1A1 ATP1A2	9.07e-06	3	61	2	21094218
Pubmed	Tyrosine 425 within the activated erythropoietin receptor binds Syp, reduces the erythropoietin required for Syp tyrosine phosphorylation, and promotes mitogenesis.	JAK2 PTPN11	9.07e-06	3	61	2	8639815
Pubmed	Effect of resistance training on Na,K pump and Na+/H+ exchange protein densities in muscle from control and patients with type 2 diabetes.	ATP1A1 ATP1A2	9.07e-06	3	61	2	14685860
Pubmed	Glycoprotein nonmetastatic melanoma protein B (GPNMB) promotes the progression of brain glioblastoma via Na+/K+-ATPase.	ATP1A1 ATP1A3	9.07e-06	3	61	2	27836549
Pubmed	The cross-talk between angiotensin and insulin differentially affects phosphatidylinositol 3-kinase- and mitogen-activated protein kinase-mediated signaling in rat heart: implications for insulin resistance.	JAK2 IRS1	9.07e-06	3	61	2	12960006
Pubmed	Relation between ABCB1 overexpression and COX2 and ALOX5 genes in human erythroleukemia cell lines.	ALOX5 ABCB1	9.07e-06	3	61	2	33975019
Pubmed	Function of prokaryotic and eukaryotic ABC proteins in lipid transport.	ABCA1 ABCB1	9.07e-06	3	61	2	15749056
Pubmed	SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter.	ABCA1 PARD3	9.07e-06	3	61	2	18484747
Pubmed	Decreased content of ascorbic acid (vitamin C) in the brain of knockout mouse models of Na+,K+-ATPase-related neurologic disorders.	ATP1A2 ATP1A3	9.07e-06	3	61	2	33544780
Pubmed	Purification of the human alpha2 Isoform of Na,K-ATPase expressed in Pichia pastoris. Stabilization by lipids and FXYD1.	ATP1A1 ATP1A2	9.07e-06	3	61	2	18052210
Pubmed	SHPTP2 serves adapter protein linking between Janus kinase 2 and insulin receptor substrates.	JAK2 PTPN11	9.07e-06	3	61	2	8912646
Pubmed	Na(+) pump alpha 2-isoform specifically couples to contractility in vascular smooth muscle: evidence from gene-targeted neonatal mice.	ATP1A1 ATP1A2	9.07e-06	3	61	2	14627611
Pubmed	The alpha 1 isoform of Na,K-ATPase regulates cardiac contractility and functionally interacts and co-localizes with the Na/Ca exchanger in heart.	ATP1A1 ATP1A2	9.07e-06	3	61	2	15485817
Pubmed	The highly conserved cardiac glycoside binding site of Na,K-ATPase plays a role in blood pressure regulation.	ATP1A1 ATP1A2	9.07e-06	3	61	2	16243970
Pubmed	Interleukin-27 inhibits foam cell formation by promoting macrophage ABCA1 expression through JAK2/STAT3 pathway.	JAK2 ABCA1	1.81e-05	4	61	2	25194807
Pubmed	Molecular characterization of specific interactions between SHP-2 phosphatase and JAK tyrosine kinases.	JAK2 PTPN11	1.81e-05	4	61	2	8995399
Interaction	ATP1A2 interactions	ATP6V0A4 ATP1A1 ATP1A2 ATP1A3	1.03e-05	45	61	4	int:ATP1A2
Cytoband	17q23.3	TANC2 ACE	7.38e-04	30	61	2	17q23.3
Cytoband	3p25.3	SLC6A1 TTLL3	1.66e-03	45	61	2	3p25.3
GeneFamily	ATPase Na+/K+ transporting subunits	ATP1A1 ATP1A2 ATP1A3	5.72e-07	7	47	3	1208
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TANC2 DMXL2 COL15A1 TRPM5 SPTB ATP1A2 ALOX5	4.36e-09	175	61	7	f24b664b9056b5976bf2222e8013f15c09e049ad
ToppCell	facs-Large_Intestine-Distal-24m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DMXL2 COL15A1 TRPM5 SPTB ATP1A2 ALOX5	1.38e-07	173	61	6	f0eb48c1283bdde313bb75f6ffc0d2626922d24b
ToppCell	facs-Large_Intestine-Proximal-24m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DMXL2 COL15A1 TRPM5 ATP1A2 ALOX5	3.64e-06	170	61	5	c638dfde9ce30190abbe0caea1c3eb874af09857
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DMXL2 COL15A1 TRPM5 SPTB ALOX5	3.64e-06	170	61	5	17bd7fd25a2657cb536ad47e294332920f759e95
ToppCell	facs-Large_Intestine-Proximal-18m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TANC2 DMXL2 COL15A1 TRPM5 ALOX5	4.56e-06	178	61	5	09a215a0d6e98e4bb920cabda12af08ff4de3c98
ToppCell	E16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TANC2 UBE2E2 MAOB TBC1D22A WDR24	4.94e-06	181	61	5	f6629fa71bb94405f523f63a9264cacf6d15c5f4
ToppCell	10x5'-bone_marrow-Mast-Mast_cell_lympho\|bone_marrow / Manually curated celltypes from each tissue	TTLL3 CPEB3 PLA2G4A ZNF223 ALOX5	4.94e-06	181	61	5	56fa77ae31f3b7de6e441a439c33a11353b6573a
ToppCell	Control-Myeloid\|Control / Disease state, Lineage and Cell class	DMXL2 ABCA1 UBE2E2 CORO1C ALOX5	7.10e-06	195	61	5	46ce2e403ca5d757e5ba17349b6c7ce5cde1f195
ToppCell	Bronchial-10x5prime-Immune_Myeloid-Macrophage_other-Macrophage_intravascular\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DMXL2 ABCA1 CORO1C ACE ALOX5	8.02e-06	200	61	5	ea039de8bd8b325845ce361f84e600c6dad922ed
ToppCell	343B-Myeloid-Macrophage-SPP1+_Macrophage_3\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	PTPN11 TAS2R14 CORO1C ATP1A2	4.56e-05	144	61	4	5e948d4cb913ccd8f82262a1b4d20967aadab3ab
ToppCell	PBMC-Mild-Hematopoietic-Platelet-Platelet-plt_0\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MAOB SPTB IRS1 PARD3	7.73e-05	165	61	4	6799a6580c667738995cceb31cbf1c7fbdc4ff84
ToppCell	PBMC-Mild-Hematopoietic-Platelet-Platelet-plt_0\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MAOB SPTB IRS1 PARD3	7.73e-05	165	61	4	8329d780f244bc31344443b29e5a00529a016662
ToppCell	droplet-Lung-LUNG-1m-Myeloid-dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	JAK2 NLRP10 MAP3K15 GPR162	8.10e-05	167	61	4	e30e7ac8ea4399dc3c1d94fc6b857afc80a7a671
ToppCell	5'-Adult-SmallIntestine-Epithelial-Tuft-related-Tuft\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TANC2 TRPM5 PLA2G4A ALOX5	8.29e-05	168	61	4	8072d0496b7b730c4601009eaa69ec5366d26d73
ToppCell	droplet-Spleen-SPLEEN-30m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP1A3 PARD3 GRM8 GPR162	9.08e-05	172	61	4	30916a902c151907745756d14327e24adc34afef
ToppCell	10x5'-GI_large-bowel-Mast\|GI_large-bowel / Manually curated celltypes from each tissue	ABCA1 MAOB SPTB ALOX5	1.04e-04	178	61	4	d10ed2543c96e1a2373f847e0b82144771e26d07
ToppCell	10x5'-GI_large-bowel-Mast-Mast_cells\|GI_large-bowel / Manually curated celltypes from each tissue	ABCA1 MAOB SPTB ALOX5	1.04e-04	178	61	4	8fc5f735afa25ae43c2acb1c710ade6e9e093e3c
ToppCell	facs-Marrow-B-cells-3m-Myeloid-monocyte_+_promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A1 BRINP3 TRPM5 ATP1A2	1.08e-04	180	61	4	c54af6fb11484dacd3efa1f10a487376ff820a5e
ToppCell	facs-Marrow-B-cells-3m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A1 BRINP3 TRPM5 ATP1A2	1.08e-04	180	61	4	07ac979b21be2425294d9818c48b5a1e6f014c19
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BRINP3 ATP6V0A4 MAP3K15 ABCB1	1.11e-04	181	61	4	aa233b652921848af2257cc3687a7a09c3acfb67
ToppCell	PBMC-Control-Myeloid-Neutrophil-immature_Neutrophil\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TANC2 DMXL2 TMEM131L POLQ	1.18e-04	184	61	4	a8c6028d745aaa6ee7842259238694cb50ce0526
ToppCell	PBMC-Control-Myeloid-Neutrophil-immature_Neutrophil-Neu_4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TANC2 DMXL2 TMEM131L POLQ	1.18e-04	184	61	4	081d045f3bc98a36f342de7d50f39c9a888dd7eb
ToppCell	Control-Myeloid_G-immature_Neutrophil\|Control / Disease group, lineage and cell class	TANC2 DMXL2 TMEM131L POLQ	1.18e-04	184	61	4	45f873236f7e90fb78c8e291d3b5b92d121acec9
ToppCell	PBMC-Control-Myeloid-Neutrophil-immature_Neutrophil\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	TANC2 DMXL2 TMEM131L POLQ	1.18e-04	184	61	4	84c20730cd92b9aaa50077d7b625e37e7f9e91d2
ToppCell	PBMC-Control-Myeloid-Neutrophil-immature_Neutrophil-Neu_4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TANC2 DMXL2 TMEM131L POLQ	1.18e-04	184	61	4	d31d4116d1d196633784863781fa45673607a421
ToppCell	Control-Neu_4\|World / 5 Neutrophil clusters in COVID-19 patients	TANC2 DMXL2 TMEM131L MGA	1.18e-04	184	61	4	ce7f044956613118ee2e9fb6af2455c3166cb414
ToppCell	droplet-Lung-18m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TANC2 DMXL2 ABCA1 ALOX5	1.20e-04	185	61	4	4bee178ede12f56ba5f5bec44a03dc2a62c50137
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	DMXL2 TMEM131L POLQ GINS1	1.23e-04	186	61	4	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	Tuft\|World / Class top	TRPM5 SPTB ATP1A2 ALOX5	1.23e-04	186	61	4	f4d83f15ab7b49c0920a322cd832413ece7c9948
ToppCell	Tuft-tuft-2\|World / Class top	TRPM5 SPTB ATP1A2 ALOX5	1.25e-04	187	61	4	4ec6eee866619dfe13c84f5d2e812bb380d37139
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	BRINP3 COL15A1 CORO1C IRS1	1.28e-04	188	61	4	4d1e5f85342ae550086609d7680e32730b78b5d2
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC6A1 JAK2 TMEM131L ATP1A2	1.31e-04	189	61	4	127ad2ba3e794df8cce2eee3e4171bccb5aad51b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC6A1 JAK2 TMEM131L ATP1A2	1.31e-04	189	61	4	2cfb4d12f75678d1619f4743838a0e954bd57761
ToppCell	COPD-Myeloid-Macrophage_Alveolar\|COPD / Disease state, Lineage and Cell class	TANC2 UBE2E2 CORO1C ALOX5	1.33e-04	190	61	4	006e31606d637033bc81333816ee332773d36b08
ToppCell	droplet-Heart-nan-24m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL15A1 MAOB ATP1A2 ACE	1.36e-04	191	61	4	1f660ea2841324d13f63e01f1789e606c2843fc4
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA1 TRPM5 MAOB PARD3	1.39e-04	192	61	4	5b7093d5af5ae7b0e6d3a464cc56272440ecedad
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC6A1 JAK2 TMEM131L ATP1A2	1.39e-04	192	61	4	bfab13793e54de2550ee171397f7ece0625cdb4a
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC6A1 IRS1 ATP1A3 PARD3	1.39e-04	192	61	4	025fac36b862f9ca7f96fb4a1946c44ba7cbc382
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC6A1 JAK2 TMEM131L ATP1A2	1.39e-04	192	61	4	b54b0d5b88139905521c8d5d58332e89c08d589c
ToppCell	droplet-Heart-nan-24m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL15A1 MAOB ATP1A2 ACE	1.41e-04	193	61	4	0ca0439dfdcb2361ca8d1015fb874a5b5c635d31
ToppCell	droplet-Kidney-nan-21m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAOB ATP6V0A4 ATP1A1 GPR162	1.41e-04	193	61	4	b397c14ac1e34c6be3f25d4417d200bc518d3048
ToppCell	droplet-Heart-nan-24m-Mesenchymal-fibroblast\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL15A1 MAOB ATP1A2 ACE	1.41e-04	193	61	4	d08919db9601941569b9a143dad4d8e6f56a4389
ToppCell	droplet-Kidney-nan-21m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAOB ATP6V0A4 ATP1A1 GPR162	1.41e-04	193	61	4	241a60d1f0d5832638fb3e1e4b7afa7387ea3c75
ToppCell	IPF-Myeloid-Macrophage_Alveolar\|World / Disease state, Lineage and Cell class	TANC2 UBE2E2 CORO1C ALOX5	1.41e-04	193	61	4	03a43b6d235fd47488a6a61efc311a34b232c0f4
ToppCell	(07)_Brush\|World / shred by cell type and Timepoint	TRPM5 SPTB ATP1A2 ALOX5	1.41e-04	193	61	4	9af9d22a130ff97a9c37142a65e841b056d08640
ToppCell	facs-Heart-RA-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL15A1 MAOB PLA2G4A ATP1A2	1.44e-04	194	61	4	48063c9fe3e12aeff0707acada1baa2f8621f093
ToppCell	facs-Heart-RA-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL15A1 MAOB PLA2G4A ATP1A2	1.44e-04	194	61	4	4f31d2cf7eb37b45fefc4da5b41aac0bfdd847b3
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC6A1 JAK2 TMEM131L ATP1A2	1.44e-04	194	61	4	5c3b2b05d1e4f146551fe4c920263d8e6ca34de3
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC6A1 JAK2 TMEM131L ATP1A2	1.44e-04	194	61	4	ab9cad697f9209d2889bc02b43b502dfeb2ebfef
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC6A1 COL15A1 TMEM131L ATP1A2	1.44e-04	194	61	4	ebb038f94f49f5c655578d1b018676e10c6b7e3c
ToppCell	wk_20-22-Mesenchymal-Myofibro_&_SMC-Late_airway_SMC\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	BRINP3 MAOB IRS1 ATP1A2	1.47e-04	195	61	4	4dba732c8d8ecf0ed9ece1814dc4060402199ed9
ToppCell	Children_(3_yrs)-Immune-alveolar_macrophage_(MARCO_positive)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DMXL2 ABCA1 CORO1C ALOX5	1.47e-04	195	61	4	9d649ac7d2af313481069c95349efc0c68449e2b
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)\|Adult / Lineage, Cell type, age group and donor	DMXL2 ABCA1 CORO1C ALOX5	1.47e-04	195	61	4	55e25f702af19146a161861cfd15f40bbda1dc35
ToppCell	Bronchial-NucSeq\|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations	TANC2 TBC1D22A RFX7 PARD3	1.50e-04	196	61	4	ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCell	droplet-Heart-HEART-1m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL15A1 IRS1 ATP1A2 ACE	1.50e-04	196	61	4	59b5b5a0c123d0423abd19c312514849004b903b
ToppCell	droplet-Heart-HEART-1m-Mesenchymal-fibroblast\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL15A1 IRS1 ATP1A2 ACE	1.53e-04	197	61	4	b16add329bb35a558287ede51353010dde5bc029
ToppCell	droplet-Heart-HEART\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TANC2 COL15A1 IRS1 ATP1A2	1.53e-04	197	61	4	9654472f1d4c9a6caadf1ff61a84902d171e9eb4
ToppCell	droplet-Heart-HEART-1m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TANC2 COL15A1 IRS1 ATP1A2	1.53e-04	197	61	4	1ec3c05a5d4163df2cf0d168e28a3f1d35364da2
ToppCell	distal-3-mesenchymal-Fibromyocyte\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	BRINP3 COL15A1 IRS1 ATP1A2	1.56e-04	198	61	4	dc93886439a378a0c71e99acb8081bfb6b6d467b
ToppCell	Lung_Parenchyma-Control-Myeloid-Mast_cell\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	MAOB SDR42E2 SPTB ABCB1	1.56e-04	198	61	4	0af55f2b859e4626e23e2733bf9ae2ace4547079
ToppCell	Tracheal-10x3prime_v2-Epithelial-Epi_airway_neuro-secretory-Ionocyte_n_Brush\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ATP6V0A4 IRS1 ZNF223 PDE11A	1.56e-04	198	61	4	62059185afdf66126a6fbc899ce611c47e7a0feb
ToppCell	Lung_Parenchyma-Control-Myeloid-Mast_cell-Mast_cells-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MAOB SDR42E2 SPTB ABCB1	1.56e-04	198	61	4	f75800b4f3cf0d493226db8db7c949caade0ff90
ToppCell	Parenchyma_Control_(B.)-Immune-TX-Mast_cells\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	MAOB SDR42E2 SPTB ABCB1	1.56e-04	198	61	4	45089e0adf2c00f4b0bccd701f4daebf25858006
ToppCell	distal-mesenchymal-Fibromyocyte-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	BRINP3 COL15A1 IRS1 ATP1A2	1.56e-04	198	61	4	9d1d95e7703cfc70a8ad427e400c340dbd205db8
ToppCell	Lung_Parenchyma-Control-Myeloid-Mast_cell-Mast_cells\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	MAOB SDR42E2 SPTB ABCB1	1.56e-04	198	61	4	4163220f4ccb825a8399298cfac8411eb2acc9a2
ToppCell	distal-mesenchymal-Fibromyocyte\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	BRINP3 COL15A1 IRS1 ATP1A2	1.56e-04	198	61	4	fbfac1d10e4224990a094cc84b74bbc206881423
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	TBC1D22A CPEB3 RFX7 PARD3	1.59e-04	199	61	4	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DMXL2 SZT2 ALOX5 NUTM2G	1.59e-04	199	61	4	379bbd9cecf466b902411c54d74bd9885285b1ba
ToppCell	Bronchial-10x5prime-Immune_Myeloid-Macrophage_alveolar-Macro_alv_dividing\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CORO1C POLQ GINS1 ALOX5	1.59e-04	199	61	4	e1190b1c2d21fed313bb58e24d0e6365de6e6599
ToppCell	Hematolymphoid-Endothelial-NOSTRIN\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SLC6A1 ATP1A2 PARD3 ABCB1	1.62e-04	200	61	4	032df80aa5c40991e1c1e80f9d8da106e6aeaee2
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Macroglial\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	SLC6A1 POMT1 MAGT1 ATP1A2	1.62e-04	200	61	4	3a954d9d542e52c9b181f0850a09b1bff0a0c82d
ToppCell	Control-Control-Myeloid-immature_Neutrophil\|Control / Disease, condition lineage and cell class	TANC2 DMXL2 CSE1L POLQ	1.62e-04	200	61	4	118321ac443feb42aee171baccfc4610f00a8822
ToppCell	Hematolymphoid-Endothelial-NOSTRIN---\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SLC6A1 ATP1A2 PARD3 ABCB1	1.62e-04	200	61	4	68fce28690246895fd33354b30960ebcc31aa4cc
ToppCell	Hematolymphoid-Endothelial-NOSTRIN-\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SLC6A1 ATP1A2 PARD3 ABCB1	1.62e-04	200	61	4	376b19ab5a7cd2c85f726d8ba41337d4525863e5
ToppCell	Hematolymphoid-Endothelial-NOSTRIN--\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SLC6A1 ATP1A2 PARD3 ABCB1	1.62e-04	200	61	4	7fa54370221ed61bac0e09e6bcf1f3dff202a846
ToppCell	Hematolymphoid-Endothelial-NOSTRIN----L2-6\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SLC6A1 ATP1A2 PARD3 ABCB1	1.62e-04	200	61	4	878bbbe32e3602723aa14ef32877ab2453b8c6e5
ToppCell	Hematolymphoid-Endothelial\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SLC6A1 ATP1A2 PARD3 ABCB1	1.62e-04	200	61	4	7136936d05ab344a560cf159684c881063b5430d
ToppCell	Bronchial-10x5prime-Immune_Myeloid-Macrophage_other\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DMXL2 ABCA1 CORO1C ALOX5	1.62e-04	200	61	4	2d2835f97e0ff4f99d384f18e10876575f6bdefd
ToppCell	Entopeduncular-Macroglia-POLYDENDROCYTE-P1-P1_1-Tnr\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	ADAT3 TRPM5 ALOX5	1.68e-04	78	61	3	1ddbb2247450a8b1c159f524dee15bf688748955
ToppCell	Entopeduncular-Macroglia-POLYDENDROCYTE-P1-P1_1-Tnr-Polydendrocyte.Tnr.Ctps_(Ctps)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	ADAT3 TRPM5 ALOX5	1.68e-04	78	61	3	2b0973122052bb26153f066e7b87c26f8a319698
ToppCell	Substantia_nigra-Macroglia-POLYDENDROCYTE-P1-P1_2-Tnr\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	TRPM5 PKD1L1 ALOX5	1.81e-04	80	61	3	0d02b242164d27f38f70ed77b106612fc7a3abca
ToppCell	Substantia_nigra-Macroglia-POLYDENDROCYTE-P1-P1_2\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	TRPM5 PKD1L1 ALOX5	1.81e-04	80	61	3	313344cf7309bc17ca131b92a91b24489df577e2
ToppCell	Substantia_nigra-Macroglia-POLYDENDROCYTE-P1-P1_2-Tnr-Polydendrocyte.Tnr.Tmem2_(Tmem2)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	TRPM5 PKD1L1 ALOX5	1.81e-04	80	61	3	b95e4456adb7f7d42825351f010376c10bb35380
Drug	22,23-dihydrobufalin	ATP1A1 ATP1A2 ATP1A3	1.82e-07	5	61	3	CID000195392
Drug	thevetin A	ATP1A1 ATP1A2 ATP1A3	1.82e-07	5	61	3	CID000441873
Drug	3-acetylstrophanthin	ATP1A1 ATP1A2 ATP1A3	1.82e-07	5	61	3	CID003082282
Drug	ETH157	ATP1A1 ATP1A2 ATP1A3	3.64e-07	6	61	3	CID000563154
Drug	dihydrodigitoxigenin	ATP1A1 ATP1A2 ATP1A3	6.36e-07	7	61	3	CID000107549
Drug	Digocin	ATP1A1 ATP1A2 ATP1A3 ACE ABCB1	1.24e-06	70	61	5	CID000003062
Drug	ouabagenin	ATP1A1 ATP1A2 ATP1A3	2.97e-06	11	61	3	CID000010497
Drug	A-32686	ATP1A1 ATP1A2 ATP1A3	5.13e-06	13	61	3	CID000004951
Drug	verapamil	ABCA1 CACNG6 ATP1A1 ATP1A2 ATP1A3 ACE GINS1 ALOX5 ABCB1	5.91e-06	490	61	9	CID000002520
Drug	Digoxin	ATP1A1 ATP1A2 ATP1A3 ABCB1	6.99e-06	46	61	4	ctd:D004077
Drug	NSC-84513	ATP1A1 ATP1A3 ABCB1	8.14e-06	15	61	3	CID000256927
Drug	HDMA	ATP1A1 ATP1A2 ATP1A3	1.21e-05	17	61	3	CID000131092
Drug	amyl nitrite	ATP1A1 ATP1A2 ATP1A3 ACE	1.24e-05	53	61	4	CID000008053
Drug	CP-690334-01 [459212-38-5]; Down 200; 10uM; MCF7; HT_HG-U133A	TANC2 JAK2 SOX12 PTPN11 CSE1L TBC1D22A	1.29e-05	193	61	6	3906_DN
Drug	AC1L1F3Q	ATP1A1 ATP1A2 ATP1A3	1.45e-05	18	61	3	CID000003068
Drug	acetylstrophanthidin	ATP1A1 ATP1A2 ATP1A3	1.45e-05	18	61	3	CID000006062
Drug	NSC 234205	ATP1A1 ATP1A2 ATP1A3	1.45e-05	18	61	3	CID000010104
Drug	Terbutaline hemisulfate [23031-32-5]; Up 200; 7.2uM; MCF7; HT_HG-U133A	JAK2 ABCA1 IGHMBP2 SPTB GRM8 ALOX5	1.54e-05	199	61	6	3202_UP
Drug	Ouabain	ATP1A1 ATP1A2 ATP1A3 ACE ABCB1	1.69e-05	119	61	5	ctd:D010042
Drug	oxovanadium	ATP6V0A4 ATP1A1 ATP1A3 ALOX5 ABCB1	1.76e-05	120	61	5	CID000024411
Drug	Cymarigenen	ATP1A1 ATP1A2 ATP1A3	2.02e-05	20	61	3	CID000005303
Drug	efonidipine	ABCA1 ABCB1	2.11e-05	3	61	2	ctd:C066425
Drug	AC1NST54	ATP1A1 ATP1A2 ATP1A3	2.35e-05	21	61	3	CID005315525
Drug	cardenolide	ATP1A1 ATP1A2 ATP1A3	3.12e-05	23	61	3	CID000016142
Drug	AS701	ATP1A2 ATP1A3	4.22e-05	4	61	2	CID000133528
Drug	Aldosterone	JAK2 ATP1A1 ACE ABCB1	6.03e-05	79	61	4	ctd:D000450
Drug	AC1L9LNU	JAK2 PTPN11 IRS1 GPR162	6.33e-05	80	61	4	CID000448157
Drug	trimethaphan	ATP1A1 ATP1A2 ATP1A3 ACE	6.65e-05	81	61	4	CID000023576
Drug	cholesterol phosphate	ACE ALOX5	7.02e-05	5	61	2	CID000134573
Drug	ETH615	ALOX5 ABCB1	7.02e-05	5	61	2	CID000131627
Drug	Losartan	ATP1A1 ATP1A2 ATP1A3 ACE ALOX5	8.06e-05	165	61	5	ctd:D019808
Drug	poly(vinylidene fluoride	ATP1A2 ATP1A3 ACE GPR162	9.60e-05	89	61	4	CID000006369
Drug	2,4-dinitrophenol	ATP1A1 ATP1A2 ATP1A3 ABCB1	1.00e-04	90	61	4	CID000001493
Drug	irinotecan HCl; Down 200; 100uM; MCF7; HT_HG-U133A	TANC2 JAK2 BRINP3 PARD3 DOP1A	1.04e-04	174	61	5	7530_DN
Drug	pyrazoline	MAOB ALOX5	1.05e-04	6	61	2	CID000066962
Drug	sodium; lithium	ATP1A1 ATP1A3 ACE	1.23e-04	36	61	3	CID012725854
Drug	GW8510; Down 200; 10uM; MCF7; HT_HG-U133A	JAK2 BRINP3 TMEM131L IRS1 MGA	1.31e-04	183	61	5	7062_DN
Drug	isethionate	SLC6A1 ATP1A1 ATP1A3	1.44e-04	38	61	3	CID000007866
Drug	AC1Q6A8A	ABCA1 ALOX5	1.47e-04	7	61	2	CID000160255
Drug	rishitin	ABCA1 ALOX5	1.47e-04	7	61	2	CID000108064
Drug	dihydropyrone	ATP1A2 ATP1A3	1.47e-04	7	61	2	CID000010760
Drug	N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine	ATP1A2 ATP1A3	1.47e-04	7	61	2	ctd:C481648
Drug	valinomycin	ATP1A2 ATP1A3 ABCB1	1.56e-04	39	61	3	CID000005649
Drug	orthovanadate	JAK2 ABCA1 PTPN11 IRS1 ATP1A1 ATP1A3 ABCB1	1.59e-04	435	61	7	CID000061672
Drug	aluminum chloride	ATP1A1 ATP1A2 ATP1A3 ALOX5	1.63e-04	102	61	4	ctd:C010845
Drug	Monensin sodium salt [22373-78-0]; Up 200; 5.8uM; HL60; HT_HG-U133A	COL15A1 SPTB ATP1A2 ATP1A3 PARD3	1.64e-04	192	61	5	2580_UP
Drug	tridigitoxoside	ATP1A1 ATP1A3 ABCB1	1.68e-04	40	61	3	CID000003061
Drug	tetrabenazine	MAOB ATP1A3 ABCB1	1.68e-04	40	61	3	CID000006018
Drug	Skimmianine [83-95-4]; Up 200; 15.4uM; HL60; HT_HG-U133A	SLC6A1 SPTB ATP1A3 ABCB1 PDE11A	1.72e-04	194	61	5	2504_UP
Drug	Labetalol hydrochloride [32780-64-6]; Up 200; 11uM; PC3; HT_HG-U133A	ABCA1 ATP1A3 ACE GRM8 ALOX5	1.81e-04	196	61	5	4473_UP
Drug	CID6432277	ATP1A1 ATP1A2 ATP1A3	1.81e-04	41	61	3	CID006432277
Drug	Niacin [59-67-6]; Down 200; 32.4uM; HL60; HT_HG-U133A	DMXL2 ABCA1 CSE1L GRM8 DOP1A	1.85e-04	197	61	5	3043_DN
Drug	Ticarcillin sodium [4697-14-7]; Down 200; 9.4uM; MCF7; HT_HG-U133A	SOX12 TBC1D22A IGHMBP2 AZI2 PARD3	1.85e-04	197	61	5	7185_DN
Drug	Sulfasalazine [599-79-1]; Up 200; 10uM; MCF7; HT_HG-U133A	DMXL2 ABCA1 TBC1D22A IGHMBP2 ATP6V0A4	1.90e-04	198	61	5	5446_UP
Drug	Oxybutynin chloride [1508-65-2]; Up 200; 10.2uM; PC3; HT_HG-U133A	JAK2 CSE1L SZT2 TMEM131L ACE	1.90e-04	198	61	5	7126_UP
Drug	Riluzole hydrochloride; Up 200; 14.8uM; MCF7; HT_HG-U133A	JAK2 TBC1D22A IGHMBP2 ATP6V0A4 GRM8	1.90e-04	198	61	5	4689_UP
Drug	Mephentermine hemisulfate [1212-72-2]; Up 200; 9.4uM; HL60; HT_HG-U133A	TANC2 SZT2 TBC1D22A ACE ALOX5	1.94e-04	199	61	5	2563_UP
Drug	Ofloxacin [82419-36-1]; Up 200; 11uM; MCF7; HT_HG-U133A	IGHMBP2 SPTB ATP1A2 GRM8 ALOX5	1.94e-04	199	61	5	2302_UP
Drug	Lysergol [602-85-7]; Down 200; 15.8uM; HL60; HT_HG-U133A	TBC1D22A EXD2 IGHMBP2 ZNF223 RFX7	1.94e-04	199	61	5	1325_DN
Drug	Orlistat; Down 200; 10uM; PC3; HT_HG-U133A	TANC2 TBC1D22A SPTB ALOX5 DOP1A	1.94e-04	199	61	5	6420_DN
Drug	1,2,3,6-Tgg	ACE GPR162	1.96e-04	8	61	2	CID000073178
Drug	11-keto-beta-boswellic acid	ALOX5 ABCB1	1.96e-04	8	61	2	CID006918114
Drug	thiopyrylium	ALOX5 ABCB1	1.96e-04	8	61	2	CID011344401
Drug	glutaconyl-CoA	ATP1A2 ATP1A3	1.96e-04	8	61	2	CID009543049
Drug	tiagabine	SLC6A1 ABCB1	1.96e-04	8	61	2	ctd:C059205
Drug	Epiandrosterone [481-29-8]; Down 200; 13.8uM; PC3; HT_HG-U133A	ABCA1 CSE1L TBC1D22A TMEM131L ACE	1.99e-04	200	61	5	4626_DN
Drug	lithium aluminum hydride	SLC6A1 MAOB ATP6V0A4 ATP1A2 ATP1A3 ACE	2.13e-04	320	61	6	CID000028112
Drug	choline	SLC6A1 ABCA1 PLA2G4A ATP1A1 ATP1A2 ATP1A3	2.13e-04	320	61	6	CID000000305
Drug	AC1MBZB6	ATP1A1 ATP1A3	2.51e-04	9	61	2	CID002733620
Drug	AC1L1JI6	ACE ABCB1	2.51e-04	9	61	2	CID000005051
Drug	YM-26734	PLA2G4A ALOX5	2.51e-04	9	61	2	CID009853400
Drug	phenidone	ATP1A2 ATP1A3 ALOX5	2.56e-04	46	61	3	CID000007090
Drug	Sodium Chloride	PLA2G4A ACE ALOX5 ABCB1	2.67e-04	116	61	4	ctd:D012965
Drug	BMS-181162	PLA2G4A ALOX5	3.13e-04	10	61	2	CID006438744
Drug	gomisin A	ALOX5 ABCB1	3.13e-04	10	61	2	CID000068781
Drug	B669	PLA2G4A ABCB1	3.13e-04	10	61	2	CID000155807
Drug	AC1L5KHX	IRS1 ALOX5	3.13e-04	10	61	2	CID000276752
Drug	zaprinast	ACE PDE11A	3.13e-04	10	61	2	ctd:C011145
Disease	familial hemiplegic migraine (implicated_via_orthology)	ATP1A1 ATP1A2 ATP1A3	2.25e-07	7	56	3	DOID:0060178 (implicated_via_orthology)
Disease	nervous system disease (implicated_via_orthology)	ATP1A1 ATP1A2 ATP1A3	1.41e-06	12	56	3	DOID:863 (implicated_via_orthology)
Disease	ALTERNATING HEMIPLEGIA OF CHILDHOOD 1	ATP1A2 ATP1A3	3.54e-06	2	56	2	C3549447
Disease	alternating hemiplegia of childhood (is_implicated_in)	ATP1A2 ATP1A3	3.54e-06	2	56	2	DOID:0050635 (is_implicated_in)
Disease	end stage renal disease (implicated_via_orthology)	IRS1 ACE ABCB1	7.21e-06	20	56	3	DOID:783 (implicated_via_orthology)
Disease	stomach cancer (is_implicated_in)	DAB2IP JAK2 PTPN11 ACE	1.09e-05	72	56	4	DOID:10534 (is_implicated_in)
Disease	epilepsy (implicated_via_orthology)	ATP1A1 ATP1A2 ATP1A3 GRM8 ABCB1	1.47e-05	163	56	5	DOID:1826 (implicated_via_orthology)
Disease	Prostatic Neoplasms	DAB2IP JAK2 COL15A1 IRS1 PARD3 ACE MGA ALOX5	2.03e-05	616	56	8	C0033578
Disease	Malignant neoplasm of prostate	DAB2IP JAK2 COL15A1 IRS1 PARD3 ACE MGA ALOX5	2.03e-05	616	56	8	C0376358
Disease	Alternating hemiplegia of childhood	ATP1A2 ATP1A3	2.12e-05	4	56	2	C0338488
Disease	lung carcinoma (is_marker_for)	JAK2 ACE	3.52e-05	5	56	2	DOID:3905 (is_marker_for)
Disease	coronary artery disease (is_implicated_in)	BRINP3 ABCA1 IRS1 ACE	3.98e-05	100	56	4	DOID:3393 (is_implicated_in)
Disease	Liver carcinoma	COL15A1 UBE2E2 CPEB3 IRS1 ACE GINS1 ABCB1	4.75e-05	507	56	7	C2239176
Disease	BMI-adjusted waist-hip ratio, forced expiratory volume	PTPN11 UQCC1	5.28e-05	6	56	2	EFO_0004314, EFO_0007788
Disease	response to vitamin	SLC6A1 GPR162	9.83e-05	8	56	2	GO_0033273
Disease	obstructive sleep apnea (biomarker_via_orthology)	ACE ABCB1	9.83e-05	8	56	2	DOID:0050848 (biomarker_via_orthology)
Disease	cholestasis (biomarker_via_orthology)	MAOB ACE ABCB1	1.12e-04	49	56	3	DOID:13580 (biomarker_via_orthology)
Disease	developmental disorder of mental health (implicated_via_orthology)	DAB2IP TANC2 PARD3	1.12e-04	49	56	3	DOID:0060037 (implicated_via_orthology)
Disease	angiotensin-converting enzyme measurement	TANC2 ACE	1.26e-04	9	56	2	EFO_0006515
Disease	familial Mediterranean fever (is_implicated_in)	ACE ABCB1	1.26e-04	9	56	2	DOID:2987 (is_implicated_in)
Disease	epilepsy (is_implicated_in)	ATP1A3 ABCB1	1.26e-04	9	56	2	DOID:1826 (is_implicated_in)
Disease	Depressive disorder	SLC6A1 MAOB ATP1A3 ACE ABCB1	2.21e-04	289	56	5	C0011581
Disease	hyperhomocysteinemia (biomarker_via_orthology)	ATP1A1 ATP1A2	2.31e-04	12	56	2	DOID:9279 (biomarker_via_orthology)
Disease	Hematologic Neoplasms	JAK2 ABCB1	2.31e-04	12	56	2	C0376545
Disease	leukemia (is_implicated_in)	JAK2 ACE	2.72e-04	13	56	2	DOID:1240 (is_implicated_in)
Disease	Bipolar Disorder	MAOB PLA2G4A ATP1A1 ATP1A2 ATP1A3 ACE	2.83e-04	477	56	6	C0005586
Disease	type 2 diabetes mellitus (is_implicated_in)	ABCA1 IRS1 ACE ABCB1	3.16e-04	171	56	4	DOID:9352 (is_implicated_in)
Disease	ulcerative colitis (is_implicated_in)	JAK2 ABCB1	4.72e-04	17	56	2	DOID:8577 (is_implicated_in)
Disease	portal hypertension (implicated_via_orthology)	JAK2 ALOX5	5.93e-04	19	56	2	DOID:10762 (implicated_via_orthology)
Disease	ankylosing spondylitis (is_implicated_in)	JAK2 ACE	5.93e-04	19	56	2	DOID:7147 (is_implicated_in)
Disease	epilepsy (biomarker_via_orthology)	SLC6A1 ABCB1	7.26e-04	21	56	2	DOID:1826 (biomarker_via_orthology)
Disease	Neurodevelopmental Disorders	SLC6A1 TANC2 PTPN11	7.44e-04	93	56	3	C1535926
Disease	reticulocyte count	ABCA1 PTPN11 CORO1C SPTB TMEM131L UQCC1 IRS1 ALOX5	7.57e-04	1045	56	8	EFO_0007986
Disease	Myocardial Infarction	DAB2IP ATP1A1 ACE	7.92e-04	95	56	3	C0027051
Disease	Coronary heart disease	IRS1 ACE	9.51e-04	24	56	2	C0010068
Disease	nephrotic syndrome (implicated_via_orthology)	ACE ALOX5	9.51e-04	24	56	2	DOID:1184 (implicated_via_orthology)
Disease	BMI-adjusted waist-hip ratio, sex interaction measurement, age at assessment	ABCA1 UQCC1 RFX7	1.06e-03	105	56	3	EFO_0007788, EFO_0008007, EFO_0008343
Disease	hepatocellular carcinoma (biomarker_via_orthology)	JAK2 ABCA1 ABCB1	1.15e-03	108	56	3	DOID:684 (biomarker_via_orthology)
Disease	Major Depressive Disorder	MAOB ACE ABCB1 PDE11A	1.18e-03	243	56	4	C1269683
Disease	Epilepsy	SLC6A1 TANC2 ABCB1	1.18e-03	109	56	3	C0014544
Disease	acute kidney failure (implicated_via_orthology)	ACE ALOX5	1.20e-03	27	56	2	DOID:3021 (implicated_via_orthology)
Disease	Schizophrenia	SLC6A1 ABCA1 MAOB PLA2G4A ACE GRM8 ABCB1	1.36e-03	883	56	7	C0036341
Disease	Mental Depression	SLC6A1 MAOB ATP1A3 ABCB1	1.39e-03	254	56	4	C0011570
Disease	Amyotrophic Lateral Sclerosis With Dementia	SLC6A1 PLA2G4A	1.39e-03	29	56	2	C0393554
Disease	Myeloid Leukemia, Chronic	JAK2 ALOX5	1.39e-03	29	56	2	C0023473
Disease	Carcinoma, Granular Cell	PTPN11 ACE ALOX5	1.41e-03	116	56	3	C0205644
Disease	Adenocarcinoma, Tubular	PTPN11 ACE ALOX5	1.41e-03	116	56	3	C0205645
Disease	Adenocarcinoma, Oxyphilic	PTPN11 ACE ALOX5	1.41e-03	116	56	3	C0205642
Disease	Carcinoma, Cribriform	PTPN11 ACE ALOX5	1.41e-03	116	56	3	C0205643
Disease	Adenocarcinoma, Basal Cell	PTPN11 ACE ALOX5	1.41e-03	116	56	3	C0205641
Disease	Adenocarcinoma	PTPN11 ACE ALOX5	1.41e-03	116	56	3	C0001418
Disease	Crohn's disease (is_implicated_in)	JAK2 ABCB1	1.49e-03	30	56	2	DOID:8778 (is_implicated_in)
Disease	Unipolar Depression	MAOB ACE ABCB1 PDE11A	1.49e-03	259	56	4	C0041696
Disease	Autistic Disorder	MAOB PLA2G4A ACE GRM8	1.53e-03	261	56	4	C0004352
Disease	Amyotrophic Lateral Sclerosis, Guam Form	SLC6A1 PLA2G4A	1.59e-03	31	56	2	C0543859
Disease	temporal lobe epilepsy (biomarker_via_orthology)	SLC6A1 ABCB1	1.59e-03	31	56	2	DOID:3328 (biomarker_via_orthology)
Disease	fear of minor pain measurement	TBC1D22A CPEB3	1.59e-03	31	56	2	EFO_0008340
Disease	Alcoholic Intoxication, Chronic	SLC6A1 MAOB ACE GRM8	1.69e-03	268	56	4	C0001973
Disease	hypertension (implicated_via_orthology)	ATP1A1 ACE ALOX5	1.87e-03	128	56	3	DOID:10763 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
SDNMQHAYWELKREM	AZI2	216	Q9H6S1
AAMQSHMERAVWAAR	ADAT3	171	Q96EY9
IMHLWTMDSNFQRRY	BRINP3	341	Q76B58
TMLQQGWNATHMFRV	ACE	311	P12821
ELFSMRSWSDMRQEV	ABCA1	271	O95477
RSWSDMRQEVMFLTN	ABCA1	276	O95477
DMHSDMIYNVSWNRN	CORO1C	171	Q9ULV4
FQMDASCVNHWRAIM	DOP1A	2121	Q5JWR5
MTTFFSHNFNEDRWR	DMXL2	1691	Q8TDJ6
MMWSNFFLQEENRRR	CACNG6	1	Q9BXT2
YHNMFALMSETERIW	JAK2	81	O60674
MVFRSMLRQDVSWFD	ABCB1	791	P08183
TYLDHNNFWRTMDDM	MAOB	111	P27338
FMNQFLEHEWTNMQR	DAB2IP	576	Q5VWQ8
FVLAMTSGQMWNHIR	MAGT1	226	Q9H0U3
NNSMWNEFYHRSTEM	MGA	81	Q8IWI9
FTVASLSYHRMWMVR	GPR162	106	Q16538
QMESMKHNRTWDLEF	NLRP10	551	Q86W26
LTQNRMTVAHMWFDN	ATP1A1	381	P05023
MQLESRWRQHFLDSM	EXD2	576	Q9NVH0
WRHAFNVCQLMFAML	PDE11A	666	Q9HCR9
MEWRSSMEKNEHFLQ	LRRC31	66	Q6UY01
FWRMVFQENSRVIVM	PTPN11	341	Q06124
FWMQVDDSVVAQNMH	IRS1	236	P35568
FYWILTMMQRTHSQE	GRM8	21	O00222
SFMARFSELQWRMLA	POMT1	541	Q9Y6A1
QNRMTVAHMWFDNQI	ATP1A2	381	P50993
MSFADIMWRNHFAGR	CPEB3	376	Q8NE35
GEAAWFQVHRMLMFT	FRRS1	406	Q6ZNA5
MITVFSNRLGWHNME	POLQ	761	O75417
LTQNRMTVAHMWFDN	ATP1A3	371	P13637
LFMFRFGDHKARMNW	SDR42E2	231	A6NKP2
VMTHRWNRFAMIVQG	COL15A1	156	P39059
RAFMDLTLMASWNQR	PKD1L1	2596	Q8TDX9
QHMFRQAMRTPIIWF	PARD3	341	Q8TEW0
YQSDNQASWIHRMIM	PLA2G4A	456	P47712
HWMFAMDNIIRRAVQ	MAP3K15	1111	Q6ZN16
AMREWQHTSNFDRMI	NUTM2D	311	Q5VT03
MREWQHTSNFDRMIF	NUTM2F	261	A1L443
MREWQHTSNFDRMIF	NUTM2G	261	Q5VZR2
MFRMLTNIWTVINHF	TAS2R14	81	Q9NYV8
VFARVAQRWMEFMVQ	SZT2	2521	Q5T011
TSAVVEFWERNMHQM	SLC6A1	186	P30531
LLHRWFGTDMQMINF	TMEM131L	636	A2VDJ0
INRFMHMFQSSWNDF	ALOX5	191	P09917
RDMTRMFVHPSFREW	TANC2	756	Q9HCD6
YSVMGRSWEVQHMRQ	SEC31B	331	Q9NQW1
FEDNMETWMNNFHTL	CSE1L	231	P55060
TFHFLREEKFWMMDI	ZNF223	56	Q9UK11
VLQNRHEMATYFWAM	TRPM5	526	Q9NZQ8
YMTNRAEHDRMARQW	UBE2E2	181	Q96LR5
QYRMHQAIMRWASDT	IGHMBP2	441	P38935
AFMVWSQHERRKIMD	SOX12	46	O15370
HDRNPETWHMNFRMF	ZSCAN5B	36	A6NJL1
ETWHMNFRMFSCPEE	ZSCAN5B	41	A6NJL1
MSSSRAQQMHAFSWI	RFX7	1	Q2KHR2
FRFFSMARDLLSWME	SPTB	1906	P11277
MWSSQRFQAHLQEMG	TTLL3	401	Q9Y4R7
VHFMWEDVQQRGRVM	UQCC1	176	Q9NVA1
QFAFRWMNNLLMREV	TBC1D22A	416	Q8WUA7
MFRNGTWNTHVMEES	ATP6V0A4	486	Q9HBG4
SMMVDHNIYVWDVRR	WDR24	271	Q96S15
ALRFHMAAEEMEWFN	GINS1	101	Q14691