Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	volume-sensitive anion channel activity	LRRC8A LRRC8B	4.55e-05	9	23	2	GO:0005225
GeneOntologyBiologicalProcess	cyclic-GMP-AMP transmembrane import across plasma membrane	LRRC8A LRRC8B	3.03e-05	8	22	2	GO:0140361
GeneOntologyBiologicalProcess	guanine nucleotide transmembrane transport	LRRC8A LRRC8B	4.86e-05	10	22	2	GO:1903790
GeneOntologyBiologicalProcess	cyclic nucleotide transport	LRRC8A LRRC8B	5.94e-05	11	22	2	GO:0070729
GeneOntologyBiologicalProcess	guanine nucleotide transport	LRRC8A LRRC8B	5.94e-05	11	22	2	GO:0001408
GeneOntologyBiologicalProcess	leukocyte differentiation	LRRC8A SMARCD2 DICER1 FZD5 OPA1 GNAS	1.36e-04	789	22	6	GO:0002521
GeneOntologyBiologicalProcess	regulation of neuron differentiation	IMPACT DICER1 OPA1 DDX6	1.40e-04	255	22	4	GO:0045664
GeneOntologyBiologicalProcess	lymphocyte differentiation	LRRC8A SMARCD2 DICER1 FZD5 OPA1	2.14e-04	537	22	5	GO:0030098
GeneOntologyBiologicalProcess	aspartate transmembrane transport	LRRC8A LRRC8B	2.48e-04	22	22	2	GO:0015810
GeneOntologyBiologicalProcess	intestinal epithelial cell development	DICER1 FZD5	2.96e-04	24	22	2	GO:0060576
GeneOntologyBiologicalProcess	post-embryonic development	DICER1 FZD5 GNAS	3.85e-04	135	22	3	GO:0009791
GeneOntologyBiologicalProcess	myoblast differentiation	LRRC8A SMARCD2 DICER1	3.94e-04	136	22	3	GO:0045445
GeneOntologyBiologicalProcess	C4-dicarboxylate transport	LRRC8A LRRC8B	4.33e-04	29	22	2	GO:0015740
GeneOntologyBiologicalProcess	mononuclear cell differentiation	LRRC8A SMARCD2 DICER1 FZD5 OPA1	4.81e-04	640	22	5	GO:1903131
GeneOntologyBiologicalProcess	nucleotide transmembrane transport	LRRC8A LRRC8B	4.96e-04	31	22	2	GO:1901679
GeneOntologyBiologicalProcess	intestinal epithelial cell differentiation	DICER1 FZD5	5.97e-04	34	22	2	GO:0060575
GeneOntologyBiologicalProcess	embryonic hindlimb morphogenesis	DICER1 GNAS	6.33e-04	35	22	2	GO:0035116
GeneOntologyBiologicalProcess	T cell differentiation	SMARCD2 DICER1 FZD5 OPA1	6.50e-04	382	22	4	GO:0030217
Domain	LRRC8_Pannexin-like	LRRC8A LRRC8B	1.32e-05	5	22	2	IPR021040
Domain	Pannexin_like	LRRC8A LRRC8B	1.32e-05	5	22	2	PF12534
Domain	DEAD	DICER1 DDX6	3.31e-03	73	22	2	PF00270
Domain	DEAD/DEAH_box_helicase_dom	DICER1 DDX6	3.31e-03	73	22	2	IPR011545
Domain	ZF_RING_1	ANKIB1 VPS18 PCGF1	4.63e-03	291	22	3	PS00518
Domain	ZF_RING_2	ANKIB1 VPS18 PCGF1	4.95e-03	298	22	3	PS50089
Domain	Znf_RING	ANKIB1 VPS18 PCGF1	6.34e-03	326	22	3	IPR001841
Domain	Helicase_C	DICER1 DDX6	6.97e-03	107	22	2	PF00271
Domain	HELICc	DICER1 DDX6	6.97e-03	107	22	2	SM00490
Domain	Helicase_C	DICER1 DDX6	7.10e-03	108	22	2	IPR001650
Domain	HELICASE_CTER	DICER1 DDX6	7.22e-03	109	22	2	PS51194
Domain	HELICASE_ATP_BIND_1	DICER1 DDX6	7.22e-03	109	22	2	PS51192
Domain	DEXDc	DICER1 DDX6	7.22e-03	109	22	2	SM00487
Domain	Helicase_ATP-bd	DICER1 DDX6	7.35e-03	110	22	2	IPR014001
Domain	-	DICER1 OPA1 DDX6 GNAS	1.04e-02	746	22	4	3.40.50.300
Domain	P-loop_NTPase	DICER1 OPA1 DDX6 GNAS	1.61e-02	848	22	4	IPR027417
Domain	LRR_8	LRRC8A LRRC8B	1.71e-02	171	22	2	PF13855
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	PPIL4 SMARCD2 DICER1 OPA1 VPS18 DDX6 GNAS MCM10	1.35e-06	1335	23	8	29229926
Pubmed	Selective transport of neurotransmitters and modulators by distinct volume-regulated LRRC8 anion channels.	LRRC8A LRRC8B	2.51e-06	4	23	2	28193731
Pubmed	Renal Deletion of LRRC8/VRAC Channels Induces Proximal Tubulopathy.	LRRC8A LRRC8B	4.18e-06	5	23	2	35777784
Pubmed	LRRC8 involved in B cell development belongs to a novel family of leucine-rich repeat proteins.	LRRC8A LRRC8B	4.18e-06	5	23	2	15094057
Pubmed	Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC.	LRRC8A LRRC8B	4.18e-06	5	23	2	24790029
Pubmed	Aldo-keto reductase 1b7, a novel marker for renin cells, is regulated by cyclic AMP signaling.	DICER1 AKR1B10	8.77e-06	7	23	2	26180185
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	DICER1 VPS18 GNAS MCM10	1.82e-05	242	23	4	34011540
Pubmed	Transcription is required for establishment of germline methylation marks at imprinted genes.	IMPACT GNAS	1.88e-05	10	23	2	19136628
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	PPIL4 LRRC8A SMARCD2 DICER1 DDX6 AKR1B10 GNAS	2.05e-05	1371	23	7	36244648
Pubmed	Genomic imprinting in Dicer1-hypomorphic mice.	IMPACT DICER1	2.29e-05	11	23	2	16575173
Pubmed	Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity.	LRRC8A LRRC8B	2.75e-05	12	23	2	32277911
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	PPIL4 SMARCD2 DICER1 MYOF DDX6	9.50e-05	724	23	5	36232890
Pubmed	ZFP57 dictates allelic expression switch of target imprinted genes.	IMPACT GNAS	1.24e-04	25	23	2	33500348
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	PPIL4 LRRC8A SMARCD2 MYOF DDX6 GNAS	1.31e-04	1257	23	6	36526897
Pubmed	Cytoplasmic aggregation of DDX1 in developing embryos: Early embryonic lethality associated with Ddx1 knockout.	DICER1 DDX6	1.68e-04	29	23	2	31330130
Pubmed	An Approach to Spatiotemporally Resolve Protein Interaction Networks in Living Cells.	MYOF GNAS	2.05e-04	32	23	2	28388416
Pubmed	The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase.	SEC14L4 VPS18 DDX6 GNAS	2.07e-04	453	23	4	27113764
Pubmed	Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.	SMARCD2 VPS18 DDX6 GNAS	2.14e-04	457	23	4	32968282
Pubmed	Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.	DICER1 OPA1 VPS18 PCGF1	3.37e-04	515	23	4	31617661
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	DDX6 GNAS SSUH2 DEPDC7	5.34e-04	582	23	4	20467437
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	ANKIB1 LRRC8A DICER1 MYOF VPS18	5.57e-04	1061	23	5	33845483
GeneFamily	Volume regulated anion channel subunits	LRRC8A LRRC8B	5.56e-06	5	14	2	1158
Disease	Sex Cord-Stromal Tumor	DICER1 GNAS	4.36e-07	2	20	2	C0206724
Disease	Pituitary Adenoma	DICER1 GNAS	1.57e-05	9	20	2	C0032000
Disease	Malignant Neoplasms	DICER1 AKR1B10 GNAS	8.61e-05	128	20	3	C0006826

Protein segments in the cluster

Peptide	Gene	Start	Entry
QYYAYVTERQKVHCL	DDX6	311	P26196
IDAGYRHIDCAYVYQ	AKR1B10	36	O60218
GYYRCTRYEVIQHVE	ANKIB1	561	Q9P2G1
DAGYIYCQRIDQRDY	DEPDC7	446	Q96QD5
SYHYNTITDCYQRLE	DICER1	1691	Q9UPY3
EELGFFQYYRERCHQ	GOLGA8F;	271	Q08AF8
YYNYCLIHNVQRDFI	PPIL4	36	Q8WUA2
LDRHQYNYVDAVCYE	LRRC8A	101	Q8IWT6
LRDCEYCQYHVQAQY	MCM10	406	Q7L590
THNIYAYRIYCEDKQ	IMPACT	216	Q9P2X3
DLHRQQYSYIDAVCY	LRRC8B	96	Q6P9F7
QYEVDYRHFHRTYEV	KCNJ14	341	Q9UNX9
YYYQRHFVDSELECN	OPA1	861	O60313
ASIVVACYLYEQHYR	FZD5	461	Q13467
EELGFFQYYRERCHQ	GOLGA8DP	271	Q0D2H9
KSYYLCEQVRLQYEH	SEC14L4	266	Q9UDX3
YCHVRETERDENTYY	MAP3K19	671	Q56UN5
HYYRYDEQLNLCLER	PCGF1	161	Q9BSM1
YERSNEYQLIDCAQY	GNAS	806	Q5JWF2
RHYRYEIVCSEYQEN	TMEM150C	216	B9EJG8
DGHEREYINCNRYFR	SMARCD2	346	Q92925
DHQVYAVDYPERYCC	SSUH2	356	Q9Y2M2
YERVVAYHCQHEAYE	VPS18	566	Q9P253
CNFDRVYIYHLRCYV	MYOF	1131	Q9NZM1