Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	Kazal_2	SLCO1C1 FSTL5 C6	1.99e-04	36	59	3	PF07648
Domain	Plexin_cytopl	PLXNA1 PLXNA2	3.48e-04	9	59	2	PF08337
Domain	Plexin_cytoplasmic_RasGAP_dom	PLXNA1 PLXNA2	3.48e-04	9	59	2	IPR013548
Domain	Plexin	PLXNA1 PLXNA2	3.48e-04	9	59	2	IPR031148
Domain	KAZAL	SLCO1C1 FSTL5 C6	4.13e-04	46	59	3	SM00280
Domain	MAC_perforin	ASTN1 C6	4.34e-04	10	59	2	IPR001862
Domain	LDLRA_1	C6 ALK SORL1	4.68e-04	48	59	3	PS01209
Domain	LDLRA_2	C6 ALK SORL1	4.98e-04	49	59	3	PS50068
Domain	LDrepeatLR_classA_rpt	C6 ALK SORL1	4.98e-04	49	59	3	IPR002172
Domain	LDLa	C6 ALK SORL1	4.98e-04	49	59	3	SM00192
Domain	KAZAL_2	SLCO1C1 FSTL5 C6	5.28e-04	50	59	3	PS51465
Domain	Kazal_dom	SLCO1C1 FSTL5 C6	5.60e-04	51	59	3	IPR002350
Domain	MACPF	ASTN1 C6	6.34e-04	12	59	2	SM00457
Domain	MACPF	ASTN1 C6	6.34e-04	12	59	2	IPR020864
Domain	EGF-like_dom	HGFAC ASTN1 C6 TECTA SORL1	1.13e-03	249	59	5	IPR000742
Domain	Kringle	HGFAC KREMEN1	1.29e-03	17	59	2	IPR000001
Domain	Kringle_CS	HGFAC KREMEN1	1.29e-03	17	59	2	IPR018056
Domain	KRINGLE_2	HGFAC KREMEN1	1.29e-03	17	59	2	PS50070
Domain	Kringle	HGFAC KREMEN1	1.29e-03	17	59	2	PF00051
Domain	KRINGLE_1	HGFAC KREMEN1	1.29e-03	17	59	2	PS00021
Domain	KR	HGFAC KREMEN1	1.29e-03	17	59	2	SM00130
Domain	IPT	PLXNA1 PLXNA2	3.27e-03	27	59	2	SM00429
Domain	TIG	PLXNA1 PLXNA2	4.30e-03	31	59	2	PF01833
Domain	Sema	PLXNA1 PLXNA2	4.30e-03	31	59	2	SM00630
Domain	Semap_dom	PLXNA1 PLXNA2	4.30e-03	31	59	2	IPR001627
Domain	Sema	PLXNA1 PLXNA2	4.30e-03	31	59	2	PF01403
Domain	SEMA	PLXNA1 PLXNA2	4.30e-03	31	59	2	PS51004
Domain	Ig_E-set	ARRB1 PLXNA1 PLXNA2	4.35e-03	104	59	3	IPR014756
Domain	PSI	PLXNA1 PLXNA2	4.58e-03	32	59	2	PF01437
Domain	IPT	PLXNA1 PLXNA2	4.58e-03	32	59	2	IPR002909
Domain	Kringle-like	HGFAC KREMEN1	4.58e-03	32	59	2	IPR013806
Domain	Plexin_repeat	PLXNA1 PLXNA2	4.58e-03	32	59	2	IPR002165
Domain	EGF_3	HGFAC ASTN1 C6 SORL1	6.47e-03	235	59	4	PS50026
Domain	EGF	HGFAC ASTN1 TECTA SORL1	6.47e-03	235	59	4	SM00181
Domain	LDLR_class-A_CS	C6 SORL1	7.08e-03	40	59	2	IPR023415
Domain	PSI	PLXNA1 PLXNA2	8.52e-03	44	59	2	IPR016201
Domain	Ldl_recept_a	C6 SORL1	8.90e-03	45	59	2	PF00057
Domain	PSI	PLXNA1 PLXNA2	9.29e-03	46	59	2	SM00423
Domain	-	ALK SORL1	9.29e-03	46	59	2	4.10.400.10
Domain	EGF-like_CS	HGFAC ASTN1 C6 SORL1	9.30e-03	261	59	4	IPR013032
Pubmed	The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease.	GAD1 SLCO1C1 SLC6A19 CDH11 SLC27A2 SORL1	2.67e-06	212	64	6	19521566
Pubmed	Plexin/neuropilin complexes mediate repulsion by the axonal guidance signal semaphorin 3A.	PLXNA1 PLXNA2	3.33e-06	2	64	2	10781943
Pubmed	PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling.	ADCY10 PDE2A	3.33e-06	2	64	2	28463107
Pubmed	TAK1 represses transcription of the human telomerase reverse transcriptase gene.	MAP3K7 TERT	3.33e-06	2	64	2	17325661
Pubmed	PlexinA1 deficiency in BALB/cAJ mice leads to excessive self-grooming and reduced prepulse inhibition.	GAD1 PLXNA1	3.33e-06	2	64	2	33163687
Pubmed	Structural Basis for Plexin Activation and Regulation.	PLXNA1 PLXNA2	9.99e-06	3	64	2	27397516
Pubmed	Identification of plexin family molecules in mice.	PLXNA1 PLXNA2	9.99e-06	3	64	2	8806646
Pubmed	Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins.	ARRB1 CHRM1	9.99e-06	3	64	2	17272726
Pubmed	A20 and ABIN-3 possibly promote regression of trehalose 6,6'-dimycolate (TDM)-induced granuloma by interacting with an NF-kappa B signaling protein, TAK-1.	TNIP3 MAP3K7	9.99e-06	3	64	2	22173278
Pubmed	Fyn-dependent phosphorylation of PlexinA1 and PlexinA2 at conserved tyrosines is essential for zebrafish eye development.	PLXNA1 PLXNA2	9.99e-06	3	64	2	29091353
Pubmed	Repulsive and attractive semaphorins cooperate to direct the navigation of cardiac neural crest cells.	PLXNA1 PLXNA2	9.99e-06	3	64	2	18625214
Pubmed	Plexins promote Hedgehog signaling through their cytoplasmic GAP activity.	PLXNA1 PLXNA2	9.99e-06	3	64	2	36169302
Pubmed	Differential expression of plexin-A subfamily members in the mouse nervous system.	PLXNA1 PLXNA2	9.99e-06	3	64	2	11241833
Pubmed	EML4-ALK induces cellular senescence in mortal normal human cells and promotes anchorage-independent growth in hTERT-transduced normal human cells.	TERT ALK	9.99e-06	3	64	2	33761896
Pubmed	Clinical utility of TERT promoter mutations and ALK rearrangement in thyroid cancer patients with a high prevalence of the BRAF V600E mutation.	TERT ALK	9.99e-06	3	64	2	26857243
Pubmed	Chromosome assignment of four plexin A genes (Plxna1, Plxna2, Plxna3, Plxna4) in mouse, rat, Syrian hamster and Chinese hamster.	PLXNA1 PLXNA2	2.00e-05	4	64	2	11306810
Pubmed	The cellular senescence of leukemia-initiating cells from acute lymphoblastic leukemia is postponed by β-Arrestin1 binding with P300-Sp1 to regulate hTERT transcription.	ARRB1 TERT	2.00e-05	4	64	2	28425985
Pubmed	PlexinA polymorphisms mediate the developmental trajectory of human corpus callosum microstructure.	PLXNA1 PLXNA2	2.00e-05	4	64	2	25518740
Pubmed	Determination of cell adhesion sites of neuropilin-1.	PLXNA1 PLXNA2	2.00e-05	4	64	2	10725340
Pubmed	A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor.	PLXNA1 PLXNA2	2.00e-05	4	64	2	8570614
Pubmed	Semaphorin 5A inhibits synaptogenesis in early postnatal- and adult-born hippocampal dentate granule cells.	PLXNA1 PLXNA2	3.32e-05	5	64	2	25313870
Pubmed	Lack of molecular-anatomical evidence for GABAergic influence on axon initial segment of cerebellar Purkinje cells by the pinceau formation.	GAD1 BSN	3.32e-05	5	64	2	22764252
Pubmed	TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation.	TNIP3 MAP3K7	4.98e-05	6	64	2	32268115
Pubmed	ACE2 interaction with cytoplasmic PDZ protein enhances SARS-CoV-2 invasion.	ARRB1 SLC6A19	4.98e-05	6	64	2	34189428
Pubmed	Expression and function of semaphorin 3A and its receptors in human monocyte-derived macrophages.	PLXNA1 PLXNA2	4.98e-05	6	64	2	19480842
Pubmed	Semaphorin-6A controls guidance of corticospinal tract axons at multiple choice points.	PLXNA1 PLXNA2	6.96e-05	7	64	2	19063725
Pubmed	Increased proximal bifurcation of CA1 pyramidal apical dendrites in sema3A mutant mice.	PLXNA1 PLXNA2	6.96e-05	7	64	2	19655386
Pubmed	Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors.	PLXNA1 PLXNA2	6.96e-05	7	64	2	10520994
Pubmed	The expression of plexins during mouse embryogenesis.	PLXNA1 PLXNA2	9.27e-05	8	64	2	15661641
Pubmed	Integration of opposing semaphorin guidance cues in cortical axons.	PLXNA1 PLXNA2	9.27e-05	8	64	2	22368082
Pubmed	PlexinA2 and semaphorin signaling during cardiac neural crest development.	PLXNA1 PLXNA2	1.19e-04	9	64	2	11688557
Pubmed	The role of neuropilins in cell signalling.	PLXNA1 PLXNA2	1.19e-04	9	64	2	19909241
Pubmed	Plexin A3 and plexin A4 convey semaphorin signals during facial nerve development.	PLXNA1 PLXNA2	1.49e-04	10	64	2	18804103
Pubmed	Maternal thyroid hormone is required for parvalbumin neurone development in the anterior hypothalamic area.	GAD1 SLCO1C1	1.49e-04	10	64	2	29377458
Pubmed	Class 3 semaphorins negatively regulate dermal lymphatic network formation.	PLXNA1 PLXNA2	1.81e-04	11	64	2	26319580
Pubmed	Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population.	GAD1 BSN PLXNA2	2.08e-04	62	64	3	19367581
Pubmed	Functional loss of semaphorin 3C and/or semaphorin 3D and their epistatic interaction with ret are critical to Hirschsprung disease liability.	PLXNA1 PLXNA2	2.17e-04	12	64	2	25839327
Pubmed	PLXNA1 and PLXNA3 cooperate to pattern the nasal axons that guide gonadotropin-releasing hormone neurons.	PLXNA1 PLXNA2	2.17e-04	12	64	2	31690636
Pubmed	On and off retinal circuit assembly by divergent molecular mechanisms.	PLXNA1 PLXNA2	2.17e-04	12	64	2	24179230
Pubmed	Deletion of Sema3a or plexinA1/plexinA3 causes defects in sensory afferent projections of statoacoustic ganglion neurons.	PLXNA1 PLXNA2	2.17e-04	12	64	2	23991118
Pubmed	Qki5 safeguards spinal motor neuron function by defining the motor neuron-specific transcriptome via pre-mRNA processing.	GAD1 MAP3K7	2.17e-04	12	64	2	39226364
Pubmed	Transcriptome profiling reveals expression signatures of cranial neural crest cells arising from different axial levels.	PLXNA1 PLXNA2	2.17e-04	12	64	2	28407732
Pubmed	Transmembrane semaphorin signalling controls laminar stratification in the mammalian retina.	PLXNA1 PLXNA2	2.17e-04	12	64	2	21270798
Pubmed	Analysis of Cdh22 expression and function in the developing mouse brain.	GAD1 CDH11	2.57e-04	13	64	2	21761482
Pubmed	Functional assembly of accessory optic system circuitry critical for compensatory eye movements.	PLXNA1 PLXNA2	2.57e-04	13	64	2	25959730
Pubmed	Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.	PLXNA1 PLXNA2	2.57e-04	13	64	2	10520995
Pubmed	Differential gene expression in migrating cortical interneurons during mouse forebrain development.	GAD1 ASTN1	2.57e-04	13	64	2	20151419
Pubmed	Plexin signaling via off-track and rho family GTPases.	PLXNA1 PLXNA2	2.57e-04	13	64	2	11604131
Pubmed	Thyroid Hormone Transporter Deficiency in Mice Impacts Multiple Stages of GABAergic Interneuron Development.	GAD1 SLCO1C1	2.57e-04	13	64	2	34339499
Pubmed	Semaphorin3A, Neuropilin-1, and PlexinA1 are required for lymphatic valve formation.	PLXNA1 PLXNA2	2.57e-04	13	64	2	22723296
Pubmed	Co-duplication of olfactory receptor and MHC class I genes in the mouse major histocompatibility complex.	OR12D1 OR14J1	2.57e-04	13	64	2	14506126
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	TBC1D5 MAP3K7 ZNF281 ALG1 ZUP1 SLC27A2	2.58e-04	481	64	6	28190767
Pubmed	A midline switch of receptor processing regulates commissural axon guidance in vertebrates.	PLXNA1 PLXNA2	2.99e-04	14	64	2	20159958
Pubmed	Altered proliferative ability of neuronal progenitors in PlexinA1 mutant mice.	GAD1 PLXNA1	2.99e-04	14	64	2	25975775
Pubmed	Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.	KREMEN1 SLC6A19 TERT	3.37e-04	73	64	3	25086665
Pubmed	Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis.	LRRC34 TERT	3.45e-04	15	64	2	23583980
Pubmed	The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.	PHC3 SMARCA5	3.93e-04	16	64	2	12167701
Pubmed	Allocation of paraventricular and supraoptic neurons requires Sim1 function: a role for a Sim1 downstream gene PlexinC1.	PLXNA1 PLXNA2	3.93e-04	16	64	2	17356169
Pubmed	Optic chiasm presentation of Semaphorin6D in the context of Plexin-A1 and Nr-CAM promotes retinal axon midline crossing.	PLXNA1 PLXNA2	3.93e-04	16	64	2	22632726
Pubmed	Expression of the semaphorins Sema 3D and Sema 3F in the developing parathyroid and thymus.	PLXNA1 PLXNA2	3.93e-04	16	64	2	18489001
Pubmed	Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections.	PLXNA1 PLXNA2	4.45e-04	17	64	2	11683995
Pubmed	Semaphorin signaling facilitates cleft formation in the developing salivary gland.	PLXNA1 PLXNA2	4.45e-04	17	64	2	17626059
Pubmed	Neuronal 3',3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in Allan-Herndon-Dudley syndrome.	GAD1 SLCO1C1	4.45e-04	17	64	2	19641107
Pubmed	PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development.	PLXNA1 PLXNA2	5.59e-04	19	64	2	15239958
Pubmed	Robo1 regulates semaphorin signaling to guide the migration of cortical interneurons through the ventral forebrain.	GAD1 PLXNA1	5.59e-04	19	64	2	21508241
Pubmed	Phosphoproteome analysis of the human mitotic spindle.	PHC3 SMARCA5 TERT ALK	6.18e-04	210	64	4	16565220
Pubmed	Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons.	GAD1 SORL1	6.20e-04	20	64	2	12130536
Pubmed	A dual-strategy expression screen for candidate connectivity labels in the developing thalamus.	PLXNA1 CDH11 PLXNA2	6.43e-04	91	64	3	28558017
Pubmed	Class 5 transmembrane semaphorins control selective Mammalian retinal lamination and function.	PLXNA1 PLXNA2	6.84e-04	21	64	2	21835343
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	SMARCA5 ZNF280D TERT PLXNA1 PLXNA2 ZMYM5 ZUP1	7.00e-04	808	64	7	20412781
Pubmed	Genes expressed in Atoh1 neuronal lineages arising from the r1/isthmus rhombic lip.	PDE2A PLXNA1 PLXNA2	7.29e-04	95	64	3	21440680
Pubmed	Zic deficiency in the cortical marginal zone and meninges results in cortical lamination defects resembling those in type II lissencephaly.	GAD1 SORL1	7.52e-04	22	64	2	18448648
Pubmed	Zic2-dependent axon midline avoidance controls the formation of major ipsilateral tracts in the CNS.	PLXNA1 PLXNA2	8.23e-04	23	64	2	24360543
Pubmed	A semaphorin code defines subpopulations of spinal motor neurons during mouse development.	PLXNA1 PLXNA2	8.96e-04	24	64	2	15869472
Pubmed	A radial axis defined by semaphorin-to-neuropilin signaling controls pancreatic islet morphogenesis.	PLXNA1 PLXNA2	8.96e-04	24	64	2	28893946
Pubmed	Genome-wide association study identifies multiple loci associated with bladder cancer risk.	LRRC34 TERT	1.05e-03	26	64	2	24163127
Pubmed	The structural role of radial glial endfeet in confining spinal motor neuron somata is controlled by the Reelin and Notch pathways.	PLXNA1 PLXNA2	1.05e-03	26	64	2	23988635
Pubmed	Slit and Semaphorin signaling governed by Islet transcription factors positions motor neuron somata within the neural tube.	PLXNA1 PLXNA2	1.14e-03	27	64	2	25843547
Pubmed	Phrenic-specific transcriptional programs shape respiratory motor output.	GAD1 CDH11	1.14e-03	27	64	2	31944180
Pubmed	Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.	ZFHX2 ALK PLXNA1 PLXNA2	1.20e-03	251	64	4	29031500
Pubmed	Expression of Robo/Slit and Semaphorin/Plexin/Neuropilin family members in the developing hypothalamic paraventricular and supraoptic nuclei.	PLXNA1 PLXNA2	1.22e-03	28	64	2	18617019
Pubmed	Genetic risk profiling and prediction of disease course in Crohn's disease patients.	GPC5 BSN	1.22e-03	28	64	2	19422935
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	SAMD9 TBC1D5 METTL16 CNOT4 ALG1 SORL1	1.25e-03	650	64	6	38777146
Pubmed	A three-stage genome-wide association study of general cognitive ability: hunting the small effects.	MAP3K7 ZNF281	1.31e-03	29	64	2	20306291
Pubmed	Identification of molecules preferentially expressed beneath the marginal zone in the developing cerebral cortex.	HS6ST2 SORL1	1.40e-03	30	64	2	18055048
Pubmed	Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development.	MON2 VPS13C	1.50e-03	31	64	2	25838543
Pubmed	Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers.	PHC3 SMARCA5 ZNF280D	1.57e-03	124	64	3	20850016
Pubmed	Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women.	FSTL5 GPC5	1.70e-03	33	64	2	20966902
Pubmed	Genetical genomic determinants of alcohol consumption in rats and humans.	GAD1 NPY5R CHRM1	1.80e-03	130	64	3	19874574
Pubmed	SLX4IP acts with SLX4 and XPF-ERCC1 to promote interstrand crosslink repair.	PDE2A SORL1	1.80e-03	34	64	2	31495888
Cytoband	3q26.2	PHC3 LRRC34	6.57e-04	27	64	2	3q26.2
Cytoband	5p15.33	SLC6A19 TERT	9.24e-04	32	64	2	5p15.33
Cytoband	22q12.1	KREMEN1 PITPNB	9.24e-04	32	64	2	22q12.1
Cytoband	Ensembl 112 genes in cytogenetic band chr15q21	TRIM69 ZNF280D SLC27A2	1.98e-03	177	64	3	chr15q21
GeneFamily	Plexins	PLXNA1 PLXNA2	2.35e-04	9	47	2	683
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Gpc3_Slc18a3\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	GAD1 NPY5R HS6ST2 FSTL5 TECTA	3.48e-06	163	63	5	ec9a20cfe0d69430f9c68cddd1ab0e4a3e4554b8
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Degenerative_Distal_Convoluted_Tubule_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GAD1 ABCA5 HS6ST2 GPC5 SORL1	5.20e-06	177	63	5	dc846d0feb94d4c289553cc3ac9dac81d10409cb
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-Neuronal-Interneuron\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	HGFAC GAD1 TNIP3 ALK	2.98e-05	125	63	4	eafc39072467e209c9fe3a4fa41cb09507a42e82
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	GAD1 NPY5R FSTL5 TECTA	4.51e-05	139	63	4	408bc31aa5e1c2b379f79198fe8b5411f8d7bd08
ToppCell	PND01-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal-Deuterosomal_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRRC34 TEX50 HS6ST2 SPACA3	6.23e-05	151	63	4	633ed52dd3b4cf1e87432cf0a1ca187d7b204e83
ToppCell	PND01-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRRC34 TEX50 HS6ST2 SPACA3	6.23e-05	151	63	4	e335dad89e0a44cdd302b9653154ba5d1ee5fe1a
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Degenerative_Distal_Convoluted_Tubule_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CKMT2 ABCA5 HS6ST2 GPC5	6.55e-05	153	63	4	98670bbce4a770af244f033cdd2d54db57200ca8
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	HDAC9 GAD1 NPY5R ALK	7.61e-05	159	63	4	7f29f9dcf25ffa1822b137c571e9ac16defc6292
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	FSTL5 DGKB GPC5 ALK	7.61e-05	159	63	4	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	Frontal_cortex-Neuronal-Inhibitory\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	GAD1 FSTL5 ALK SLC27A2	9.63e-05	169	63	4	78eb70dd916724e476eabccf18fb7fcec4210308
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	HDAC9 GAD1 NPY5R FSTL5	1.03e-04	172	63	4	7e1a7700a4c2b1d100da1d6e475e73498ebb605a
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GAD1 VPS13C ZFHX2 BSN	1.08e-04	174	63	4	f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Ptprt_Pkp2\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	GAD1 NPY5R HS6ST2 FSTL5	1.13e-04	176	63	4	05ec715439f2eb1696f5d8855da0dd1dd70effd0
ToppCell	390C-Lymphocytic-ILC-ILC-1\|390C / Donor, Lineage, Cell class and subclass (all cells)	TNIP3 DTX2 PLXNA2 SLC27A2	1.20e-04	179	63	4	e7045e27f0eb88f552b31c04b56d78e5ccd7a36c
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC GAD1 FSTL5 ALK	1.25e-04	181	63	4	03a303cd2f366f09c18b118bbba6f5e3f95ad56c
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CKMT2 GAD1 ABCA5 GPC5	1.28e-04	182	63	4	5f513bbb7125956eb528e3120de3fd776770a7c3
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FSTL5 TECTA CDH11 PLXNA2	1.28e-04	182	63	4	05c167158815bf25d509df59ab386e1990712765
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A GPC5 CHRM1 PLXNA2	1.31e-04	183	63	4	dc19857b66dcadbf7c87de91f7b1f4e8ef2857ed
ToppCell	PCW_05-06-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	KREMEN1 FSTL5 GPC5 SLC27A2	1.31e-04	183	63	4	c5b10571599dc26476170b54b53f09c23e6b3117
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A GPC5 CHRM1 PLXNA2	1.31e-04	183	63	4	4759560e5b4f4e5a00e5f933e3451a27c7c4aefe
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_VIP_PRSS8\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC GAD1 FSTL5 C6	1.39e-04	186	63	4	fef543f188edb0d1704d9c6ace366a0f8017bf53
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	VPS13C DGKB ASTN1 CDH11	1.39e-04	186	63	4	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC GAD1 FSTL5 ALK	1.42e-04	187	63	4	d2ffb2f34f07b0dd5d3cb3ee0275f46ebecf4146
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GAD1 ABCA5 HS6ST2 GPC5	1.45e-04	188	63	4	eec3d353e51358db4c7621265ee0fdd4298e5b0e
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC GAD1 FSTL5 ALK	1.45e-04	188	63	4	433a25fe52914e07e7ba695881f9bcca2d9467ff
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GAD1 ABCA5 HS6ST2 GPC5	1.45e-04	188	63	4	bc089cd73d283ed7d2ecbb3936673b4edc89f666
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	KREMEN1 FSTL5 GPC5 SORL1	1.48e-04	189	63	4	7659c7bbd58ee959a159294fb8d17317bbcc5681
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GAD1 ABCA5 HS6ST2 GPC5	1.48e-04	189	63	4	f51cdc9a47371cab8ed9ae63a6f14da07ede446c
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GAD1 ABCA5 HS6ST2 GPC5	1.48e-04	189	63	4	977a813e5d7a5a561c1fced2bbf21c20056b88d8
ToppCell	pdx-Tumor_cells-T8\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	ABCA5 GPC5 C6 SLC27A2	1.51e-04	190	63	4	b05db0de9b6ae01dd30074453f7de44f7397631e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GAD1 ABCA5 HS6ST2 GPC5	1.51e-04	190	63	4	b94df372bc08de11585b2467dba8c8fffff5cd92
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GAD1 ABCA5 HS6ST2 GPC5	1.51e-04	190	63	4	e252e925600e6457fa6e362a55217f4cffa75cdb
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC GAD1 FSTL5 ALK	1.54e-04	191	63	4	7b386512284dfaa0e95358b28ee82632ee965e64
ToppCell	droplet-Kidney-nan-18m-Endothelial-kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY10 GAD1 TRIM69 PDE2A	1.57e-04	192	63	4	144503af50274eaed5cf6effa892c640eab28663
ToppCell	droplet-Kidney-nan-18m-Endothelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY10 GAD1 TRIM69 PDE2A	1.57e-04	192	63	4	c96736bb3a6bb052678b1b078f7823063ca69e6d
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GAD1 FSTL5 ALK PLXNA1	1.57e-04	192	63	4	63d1b3efe93e5ff939278ebe40bacb38218ea09b
ToppCell	wk_08-11-Epithelial-PNS-KCNIP4+_neuron\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	HDAC9 PDE2A CHRM1 ALK	1.57e-04	192	63	4	53642c88891f4e4e14b1740c5ced759b7d8b3572
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GAD1 FSTL5 ALK PLXNA1	1.57e-04	192	63	4	342842378c20267c5044bdd622515e8b9f895623
ToppCell	facs-Thymus-nan-3m-Lymphocytic-DN_to_DP_transition_(most_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KREMEN1 ZNF280D VPS13C SLC6A19	1.60e-04	193	63	4	a6a864644e1b80b7417ea0a27281e79068a3fd3d
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GAD1 ABCA5 HS6ST2 FSTL5	1.67e-04	195	63	4	a38d9dc6192aea673d96fda6b25e81223fda3abf
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW12-Neuronal-GABAergic_neurons\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	HGFAC GAD1 TNIP3 ALK	1.67e-04	195	63	4	efdea22118d5be46c5abfe8e3fbe39503390665d
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron-Neuron\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GAD1 FSTL5 BSN CHRM1	1.84e-04	200	63	4	2f481e2fd248c02a5aa2e0248c16808df142fed2
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GAD1 FSTL5 BSN CHRM1	1.84e-04	200	63	4	dc674124475edf83908b51a4e1454bc2dc4f06fa
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron-Neuron-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GAD1 FSTL5 BSN CHRM1	1.84e-04	200	63	4	bd4b9f6b37f4a3c960c4149cf0cfd2caf3327d2d
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-NMBR-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	HGFAC GAD1 FSTL5 ALK	1.84e-04	200	63	4	d416a7be1a4e6232fb58a9687774da24821f1fdd
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	HGFAC GAD1 FSTL5 ALK	1.84e-04	200	63	4	d0167f96314be78b6d867bbcc6e4396071d931b8
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-NMBR\|Neuronal / cells hierarchy compared to all cells using T-Statistic	HGFAC GAD1 FSTL5 ALK	1.84e-04	200	63	4	862db57d043bdf3cb059fbfc8b29bc1eafdf64ec
ToppCell	Neuronal-Inhibitory-iA\|Neuronal / cells hierarchy compared to all cells using T-Statistic	HGFAC GAD1 FSTL5 ALK	1.84e-04	200	63	4	5ef4a3dc18a44292184a59ced916183c0699b01e
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-NMBR--L1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	HGFAC GAD1 FSTL5 ALK	1.84e-04	200	63	4	a91345f268f13170c27309333603eb82400c9947
Drug	Melatonin [73-31-4]; Up 200; 17.2uM; PC3; HT_HG-U133A	HGFAC GAD1 SAMD9 TBC1D5 METTL16 ALK	1.25e-05	195	60	6	6293_UP
Drug	PF-00875133-00 [351322-64-0]; Down 200; 10uM; PC3; HT_HG-U133A	HDAC9 GAD1 PHC3 ZFHX2 METTL16 CNOT4	1.28e-05	196	60	6	5928_DN
Drug	Zuclopenthixol hydrochloride [633-59-0]; Down 200; 9.2uM; HL60; HT_HG-U133A	PHC3 METTL16 TERT PLXNA1 CNOT4 SLC27A2	1.28e-05	196	60	6	2936_DN
Disease	systemic lupus erythematosus, chronic lymphocytic leukemia	LRRC34 TERT	5.87e-05	6	59	2	EFO_0000095, MONDO_0007915
Disease	Mental Depression	HDAC9 GAD1 SLCO1C1 DGKB ALK	1.56e-04	254	59	5	C0011570
Disease	Alcoholic Intoxication, Chronic	GAD1 NPY5R ASTN1 ALK CDH11	2.00e-04	268	59	5	C0001973
Disease	survival time, Sepsis	SAMD9 GPC5	2.56e-04	12	59	2	EFO_0000714, HP_0100806
Disease	Depressive disorder	HDAC9 GAD1 SLCO1C1 DGKB ALK	2.83e-04	289	59	5	C0011581
Disease	nucleotide measurement	IL36G ALK PLXNA2	4.28e-04	73	59	3	EFO_0010513
Disease	attempted suicide	ABCA5 FSTL5 MAP3K7 CDH11	4.50e-04	178	59	4	EFO_0004321
Disease	Unipolar Depression	HDAC9 GAD1 ARRB1 TERT	1.81e-03	259	59	4	C0041696
Disease	insomnia measurement	HDAC9 PDE2A METTL16 CHRM1 SORL1	1.92e-03	443	59	5	EFO_0007876
Disease	Brain Tumor, Primary	DTX2 ALK	1.99e-03	33	59	2	C0750974
Disease	Primary malignant neoplasm of brain	DTX2 ALK	1.99e-03	33	59	2	C0750979
Disease	Recurrent Brain Neoplasm	DTX2 ALK	1.99e-03	33	59	2	C0750977
Disease	Neoplasms, Intracranial	DTX2 ALK	1.99e-03	33	59	2	C1527390
Disease	Benign neoplasm of brain, unspecified	DTX2 ALK	1.99e-03	33	59	2	C0496899

Protein segments in the cluster

Peptide	Gene	Start	Entry
YCCPDMINNFLGLAK	ZNF280D	261	Q6N043
DSLKCMGYCPQINPL	ABCA5	1371	Q8WWZ7
DMFGCCLPVCAVNFK	ALG1	381	Q9BT22
GFPYRECQLTNKMDC	ACTR8	326	Q9H981
DAGMPIQGQPCFCKY	AGO3	481	Q9H9G7
FGMACLICNRKEDYP	ADCY10	471	Q96PN6
ICLFNTAQYKCPVAM	ARRB1	241	P49407
DDPTLYNILMFCGCI	ASTN1	681	O14525
CIAYSDLIQMGCLKP	LRRC34	396	Q8IZ02
LLCLLAMYCNGNKDG	DTX2	451	Q86UW9
AMYCNGNKDGSLQCP	DTX2	456	Q86UW9
ALLKMQYCPHCQGLA	GPC5	251	P78333
SQLACCDMVYKLPFG	BSN	1896	Q9UPA5
GCNQMCAGYLFQPDK	GAD1	426	Q99259
CAGEPLFMLYCAIKQ	PLXNA1	1456	Q9UIW2
KECAGEPLFMLYCAI	PLXNA2	1451	O75051
FCDVPQMLKLACSYE	OR14J1	176	Q9UGF5
NYKIDCPTLARFCLM	PDE2A	631	O00408
KLYGACLNPVCLVME	MAP3K7	91	O43318
LLCLLAMYCNGNKGP	PMS2P11	36	Q13670
CMCNPPFFANQLEAK	METTL16	181	Q86W50
IPACQMPGNLGCYKD	KREMEN1	111	Q96MU8
PCAKDAYMLFQDLCQ	MON2	211	Q7Z3U7
DISPNMLCAGYFDCK	HGFAC	576	Q04756
ELLKCEFCGKMGYAN	PHC3	781	Q8NDX5
LANSPDCPQMCAYKL	PITPNB	181	P48739
MIQDGPFGSCENKYC	FSTL5	56	Q8N475
PMYFFLGNLSCLDIC	OR12D1	56	P0DN82
YCMFQLECCVKGNPA	DEFB134	51	Q4QY38
YLGIQNPEMCLYCEK	IL36G	76	Q9NZH8
PQCFKGGNQLYCVKM	C6	886	P13671
MKENYCLQAALVCLG	CDH11	1	P55287
HFNKPAYCNLCLNML	DGKB	251	Q9Y6T7
AYCNLCLNMLIGVGK	DGKB	256	Q9Y6T7
STINPMCYALCNKAF	CHRM1	411	P11229
SGCPLKEFMDCPYNL	HS6ST2	371	Q96MM7
CYVLMPFKLALCGLA	DCST2	231	Q5T1A1
AYDPLMLKHQCVCGN	HDAC9	636	Q9UKV0
VCRMYCSDLLNPNLK	SPACA3	161	Q8IXA5
NNCMAECLTPAIYAK	CKMT2	61	P17540
DNKAQYMLTCLGFCV	SLC6A19	36	Q695T7
LMCDCPQGYQLKNNT	SORL1	1056	Q92673
CAFYQDLKGMENILC	SAMD9	561	Q5K651
KLGCAMACLNYNIRA	SLC27A2	126	O14975
MSCCLNPILYGFLNN	NPY5R	416	Q15761
FCQECNNMLYPKEDK	POLR2I	16	P36954
DESQMCRKLPVGFYC	ALK	466	Q9UM73
CSYFLKNMQCPKPDC	CNOT4	196	O95628
CLKLTDMKGFFQPCY	TECTA	1691	O75443
CKMLCQYNNCTFNPV	TRIM69	81	Q86WT6
VAKPPGMCCYFAQDL	ZNF724	71	A8MTY0
YLCRQCKMAFDGEAP	ZFHX2	2451	Q9C0A1
LEKQLKQMYCPPCNC	TNIP3	256	Q96KP6
EHYNMCQVGCFLKTP	MINDY4	651	Q4G0A6
LMSLPDVCQLFKCYD	RFX8	211	Q6ZV50
CQKDNGCPQMFLYFL	SLCO1C1	541	Q9NYB5
NCICIKFDPMGKYFA	THOC3	226	Q96J01
PFGCDQCSMKFIQKY	ZNF281	316	Q9Y2X9
SYGCVKCPANNMEYL	VPS13C	2836	Q709C8
PYLLDKLCCDFANMD	TEX50	56	A0A1B0GTY4
DAYNDCLKGMLIPCI	ZUP1	376	Q96AP4
FNKYRLANGLIMNCC	ZMYM5	366	Q9UJ78
QGQLNDLDAMCKYCA	TBC1D5	596	Q92609
MQLRKCCNHPYLFDG	SMARCA5	451	O60264
LCSLCYGDMENKLFA	TERT	841	O14746
LMPFINKAGCECLNE	TXNL1	126	O43396