Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	mannosyltransferase activity	DPY19L2 DPY19L1 DPY19L2P2	5.21e-05	28	52	3	GO:0000030
GeneOntologyMolecularFunction	transcription coregulator binding	PER3 PER2 PAX6 RUNX3	4.83e-04	140	52	4	GO:0001221
GeneOntologyMolecularFunction	transcription corepressor binding	PER3 PER2 RUNX3	4.89e-04	59	52	3	GO:0001222
GeneOntologyBiologicalProcess	peptidyl-tryptophan modification	DPY19L2 DPY19L1 DPY19L2P2	3.01e-07	6	52	3	GO:0018211
GeneOntologyBiologicalProcess	protein C-linked glycosylation via tryptophan	DPY19L2 DPY19L1 DPY19L2P2	3.01e-07	6	52	3	GO:0018317
GeneOntologyBiologicalProcess	protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan	DPY19L2 DPY19L1 DPY19L2P2	3.01e-07	6	52	3	GO:0018406
GeneOntologyBiologicalProcess	protein C-linked glycosylation	DPY19L2 DPY19L1 DPY19L2P2	3.01e-07	6	52	3	GO:0018103
GeneOntologyBiologicalProcess	protein mannosylation	DPY19L2 DPY19L1 DPY19L2P2	3.34e-05	25	52	3	GO:0035268
GeneOntologyBiologicalProcess	mannosylation	DPY19L2 DPY19L1 DPY19L2P2	3.77e-05	26	52	3	GO:0097502
GeneOntologyBiologicalProcess	circadian regulation of gene expression	NCOR1 PER3 PER2 ZFHX3	3.82e-05	75	52	4	GO:0032922
GeneOntologyCellularComponent	nuclear inner membrane	DPY19L2 DPY19L1 DPY19L2P2 MAJIN	1.40e-05	59	52	4	GO:0005637
GeneOntologyCellularComponent	transcription regulator complex	HOXA11 NCOR1 PER2 ZFHX3 PAX6 RUNX3 PRDM16 BSX	1.04e-04	596	52	8	GO:0005667
MousePheno	shortened circadian behavior period	NCOR1 PER3 PER2 ZFHX3	8.21e-07	26	40	4	MP:0020470
MousePheno	abnormal circadian behavior period	NCOR1 PER3 PER2 ZFHX3	3.17e-06	36	40	4	MP:0020468
MousePheno	abnormal sperm individualization	DPY19L2 DPY19L2P2	4.77e-05	4	40	2	MP:0031372
MousePheno	submandibular gland hypoplasia	PAX6 PRDM16	7.94e-05	5	40	2	MP:0009522
MousePheno	abnormal circadian behavior	NCOR1 PER3 PER2 ZFHX3	9.40e-05	84	40	4	MP:0020467
MousePheno	decreased submandibular gland size	PAX6 PRDM16	2.21e-04	8	40	2	MP:0009520
MousePheno	abnormal rhythmic behavior	NCOR1 PER3 PER2 ZFHX3 ABCA7	2.74e-04	204	40	5	MP:0021121
MousePheno	abnormal sperm principal piece morphology	DPY19L2 TMEM232 DPY19L2P2	2.83e-04	45	40	3	MP:0009836
MousePheno	arrhythmic circadian behavior persistence	PER2 ZFHX3	2.84e-04	9	40	2	MP:0020472
MousePheno	abnormal face development	FGFR1 PAX6	2.84e-04	9	40	2	MP:0030313
Domain	-	HOXA11 NCOR1 NKX2-4 ZFHX3 POGZ PAX6 BSX	9.74e-06	283	50	7	1.10.10.60
Domain	Period_C	PER3 PER2	2.10e-05	3	50	2	PF12114
Domain	Period_circadian-like_C	PER3 PER2	2.10e-05	3	50	2	IPR022728
Domain	Homeodomain-like	HOXA11 NCOR1 NKX2-4 ZFHX3 POGZ PAX6 BSX	2.73e-05	332	50	7	IPR009057
Domain	Dpy19	DPY19L2 DPY19L1	4.20e-05	4	50	2	PF10034
Domain	Dpy-19/Dpy-19-like	DPY19L2 DPY19L1	4.20e-05	4	50	2	IPR018732
Domain	Homeobox_CS	HOXA11 NKX2-4 ZFHX3 PAX6 BSX	1.37e-04	186	50	5	IPR017970
Domain	Homeobox	HOXA11 NKX2-4 ZFHX3 PAX6 BSX	3.96e-04	234	50	5	PF00046
Domain	HOMEOBOX_1	HOXA11 NKX2-4 ZFHX3 PAX6 BSX	4.12e-04	236	50	5	PS00027
Domain	HOX	HOXA11 NKX2-4 ZFHX3 PAX6 BSX	4.20e-04	237	50	5	SM00389
Domain	Homeobox_dom	HOXA11 NKX2-4 ZFHX3 PAX6 BSX	4.36e-04	239	50	5	IPR001356
Domain	HOMEOBOX_2	HOXA11 NKX2-4 ZFHX3 PAX6 BSX	4.36e-04	239	50	5	PS50071
Domain	ABC_A	ABCA4 ABCA7	4.56e-04	12	50	2	IPR026082
Domain	PAS_fold_3	PER3 PER2	1.71e-03	23	50	2	IPR013655
Domain	PAS_3	PER3 PER2	1.71e-03	23	50	2	PF08447
Domain	Homeobox_metazoa	HOXA11 NKX2-4 BSX	1.80e-03	90	50	3	IPR020479
Domain	PAS-assoc_C	PER3 PER2	1.87e-03	24	50	2	IPR000700
Domain	PAC	PER3 PER2	2.19e-03	26	50	2	SM00086
Domain	PAC	PER3 PER2	2.19e-03	26	50	2	PS50113
Domain	PAC	PER3 PER2	2.19e-03	26	50	2	IPR001610
Domain	PAS	PER3 PER2	3.31e-03	32	50	2	SM00091
Domain	PAS	PER3 PER2	3.73e-03	34	50	2	IPR000014
Domain	PAS	PER3 PER2	3.73e-03	34	50	2	PS50112
Domain	ABC_transporter_CS	ABCA4 ABCA7	5.65e-03	42	50	2	IPR017871
Domain	-	AGO4 NYNRIN	7.03e-03	47	50	2	3.30.420.10
Domain	ABC_TRANSPORTER_2	ABCA4 ABCA7	7.32e-03	48	50	2	PS50893
Domain	ABC_tran	ABCA4 ABCA7	7.32e-03	48	50	2	PF00005
Domain	ABC_TRANSPORTER_1	ABCA4 ABCA7	7.62e-03	49	50	2	PS00211
Domain	ABC_transporter-like	ABCA4 ABCA7	7.93e-03	50	50	2	IPR003439
Domain	Cadherin_N	PCDHGA6 PCDH18	1.31e-02	65	50	2	IPR013164
Domain	Cadherin_2	PCDHGA6 PCDH18	1.31e-02	65	50	2	PF08266
Pathway	REACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION	ZFHX3 RUNX3	6.98e-05	6	31	2	MM15534
Pathway	REACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION	ZFHX3 RUNX3	9.76e-05	7	31	2	M27807
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	NCOR1 BNC2 PER3 NKX2-4 ZFHX3 POGZ PAX6 RUNX3 PRDM16 ZNF367	3.43e-07	808	53	10	20412781
Pubmed	Dopamine adjusts the circadian gene expression of Per2 and Per3 in human dermal fibroblasts from ADHD patients.	PER3 PER2	2.28e-06	2	53	2	34275001
Pubmed	Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to the nucleus with runt domain transcription factor 3 (RUNX3) in response to TGF-beta signal transduction.	ZFHX3 RUNX3	2.28e-06	2	53	2	20599712
Pubmed	Possible Association of PER2/PER3 Variable Number Tandem Repeat Polymorphism Variants with Susceptibility and Clinical Characteristics in Pancreatic Cancer.	PER3 PER2	2.28e-06	2	53	2	33393850
Pubmed	Absence of Dpy19l2, a new inner nuclear membrane protein, causes globozoospermia in mice by preventing the anchoring of the acrosome to the nucleus.	DPY19L2 DPY19L2P2	2.28e-06	2	53	2	22764053
Pubmed	A novel association of two non-synonymous polymorphisms in PER2 and PER3 genes with specific diurnal preference subscales.	PER3 PER2	2.28e-06	2	53	2	23969301
Pubmed	Variants in the circadian clock genes PER2 and PER3 associate with familial sleep phase disorders.	PER3 PER2	2.28e-06	2	53	2	38695651
Pubmed	Zfhx3-mediated genetic ablation of the SCN abolishes light entrainable circadian activity while sparing food anticipatory activity.	PER2 ZFHX3	2.28e-06	2	53	2	34632336
Pubmed	Dpy19l2-deficient globozoospermic sperm display altered genome packaging and DNA damage that compromises the initiation of embryo development.	DPY19L2 DPY19L2P2	2.28e-06	2	53	2	25354700
Pubmed	Subcellular localization of phospholipase Cζ in human sperm and its absence in DPY19L2-deficient sperm are consistent with its role in oocyte activation.	DPY19L2 DPY19L2P2	2.28e-06	2	53	2	25354701
Pubmed	Distinct functions of Period2 and Period3 in the mouse circadian system revealed by in vitro analysis.	PER3 PER2	2.28e-06	2	53	2	20072700
Pubmed	Dpy19l1, a multi-transmembrane protein, regulates the radial migration of glutamatergic neurons in the developing cerebral cortex.	DPY19L2 DPY19L1 DPY19L2P2	3.74e-06	20	53	3	22028030
Pubmed	Expression profiles of PERIOD1, 2, and 3 in peripheral blood mononuclear cells from older subjects.	PER3 PER2	6.83e-06	3	53	2	19013183
Pubmed	Dynamics of Sun5 localization during spermatogenesis in wild type and Dpy19l2 knock-out mice indicates that Sun5 is not involved in acrosome attachment to the nuclear envelope.	DPY19L2 DPY19L2P2	6.83e-06	3	53	2	25775128
Pubmed	A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light.	PER3 PER2	6.83e-06	3	53	2	9428527
Pubmed	Low-Salt Diet and Circadian Dysfunction Synergize to Induce Angiotensin II-Dependent Hypertension in Mice.	PER3 PER2	6.83e-06	3	53	2	26781276
Pubmed	Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei.	PER3 PER2	6.83e-06	3	53	2	9427249
Pubmed	Association between polymorphisms in period genes and bone density in postmenopausal Korean women.	PER3 PER2	6.83e-06	3	53	2	24678593
Pubmed	For whom the circadian clock ticks? Investigation of PERIOD and CLOCK gene variants in bipolar disorder.	PER3 PER2	6.83e-06	3	53	2	34112033
Pubmed	Photic entrainment of period mutant mice is predicted from their phase response curves.	PER3 PER2	6.83e-06	3	53	2	20826680
Pubmed	Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock.	PER3 PER2	6.83e-06	3	53	2	11395012
Pubmed	mPeriod2 Brdm1 and other single Period mutant mice have normal food anticipatory activity.	PER3 PER2	6.83e-06	3	53	2	29138421
Pubmed	A time memory engram embedded in a light-entrainable circadian clock.	PER3 PER2	6.83e-06	3	53	2	37951213
Pubmed	Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK/BMAL1 activity.	PER3 PER2	6.83e-06	3	53	2	12032351
Pubmed	Sex difference in daily rhythms of clock gene expression in the aged human cerebral cortex.	PER3 PER2	6.83e-06	3	53	2	23606611
Pubmed	Connecting the dots: potential of data integration to identify regulatory SNPs in late-onset Alzheimer's disease GWAS findings.	CLU ABCA7	6.83e-06	3	53	2	24743338
Pubmed	Deregulated expression of the PER1, PER2 and PER3 genes in breast cancers.	PER3 PER2	6.83e-06	3	53	2	15790588
Pubmed	Unwinding the differences of the mammalian PERIOD clock proteins from crystal structure to cellular function.	PER3 PER2	6.83e-06	3	53	2	22331899
Pubmed	Aberrant expression of Per1, Per2 and Per3 and their prognostic relevance in non-small cell lung cancer.	PER3 PER2	6.83e-06	3	53	2	25550826
Pubmed	Inter-individual differences in habitual sleep timing and entrained phase of endogenous circadian rhythms of BMAL1, PER2 and PER3 mRNA in human leukocytes.	PER3 PER2	6.83e-06	3	53	2	18517031
Pubmed	A light-independent oscillatory gene mPer3 in mouse SCN and OVLT.	PER3 PER2	6.83e-06	3	53	2	9707434
Pubmed	Duplication and relocation of the functional DPY19L2 gene within low copy repeats.	DPY19L2 DPY19L2P2	6.83e-06	3	53	2	16526957
Pubmed	Intracellular calcium mobilization induces period genes via MAP kinase pathways in NIH3T3 cells.	PER3 PER2	6.83e-06	3	53	2	11959112
Pubmed	Comparing expression levels of PERIOD genes PER1, PER2 and PER3 in chronic insomnia patients and medical staff working in the night shift.	PER3 PER2	6.83e-06	3	53	2	32805476
Pubmed	Sleep rhythmicity and homeostasis in mice with targeted disruption of mPeriod genes.	PER3 PER2	6.83e-06	3	53	2	15031135
Pubmed	The Circadian Clock Regulates Adipogenesis by a Per3 Crosstalk Pathway to Klf15.	PER3 PER2	6.83e-06	3	53	2	29186676
Pubmed	Nuclear export of mammalian PERIOD proteins.	PER3 PER2	6.83e-06	3	53	2	11591712
Pubmed	Period determination in the food-entrainable and methamphetamine-sensitive circadian oscillator(s).	PER3 PER2	6.83e-06	3	53	2	22891330
Pubmed	The role of phosphorylation and degradation of hPER protein oscillation in normal human fibroblasts.	PER3 PER2	6.83e-06	3	53	2	14712925
Pubmed	Differential phospholipid substrates and directional transport by ATP-binding cassette proteins ABCA1, ABCA7, and ABCA4 and disease-causing mutants.	ABCA4 ABCA7	6.83e-06	3	53	2	24097981
Pubmed	Molecular analysis of avian circadian clock genes.	PER3 PER2	6.83e-06	3	53	2	10891604
Pubmed	Period Family of Clock Genes as Novel Predictors of Survival in Human Cancer: A Systematic Review and Meta-Analysis.	PER3 PER2	6.83e-06	3	53	2	32849922
Pubmed	Circadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway.	PER3 PER2	6.83e-06	3	53	2	29269828
Pubmed	PER2 rs2304672, CLOCK rs1801260, and PER3 rs57875989 polymorphisms are not associated with juvenile myoclonic epilepsy.	PER3 PER2	6.83e-06	3	53	2	24892753
Pubmed	The complex relationship between the light-entrainable and methamphetamine-sensitive circadian oscillators: evidence from behavioral studies of Period-mutant mice.	PER3 PER2	6.83e-06	3	53	2	23869717
Pubmed	An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome.	PER3 PER2	1.36e-05	4	53	2	11232563
Pubmed	Molecular analysis of mammalian timeless.	PER3 PER2	1.36e-05	4	53	2	9856466
Pubmed	The T-type Ca2+ Channel Cav3.2 Regulates Differentiation of Neural Progenitor Cells during Cortical Development via Caspase-3.	CACNA1H PAX6	1.36e-05	4	53	2	30677486
Pubmed	Lack of Association between Genetic Polymorphism of Circadian Genes (PER2, PER3, CLOCK and OX2R) with Late Onset Depression and Alzheimer's Disease in a Sample of a Brazilian Population (Circadian Genes, Late-Onset Depression and Alzheimer's Disease).	PER3 PER2	1.36e-05	4	53	2	27335043
Pubmed	Endotoxin Disrupts Circadian Rhythms in Macrophages via Reactive Oxygen Species.	PER3 PER2	1.36e-05	4	53	2	27168152
Pubmed	Functional consequences of a CKIdelta mutation causing familial advanced sleep phase syndrome.	PER3 PER2	1.36e-05	4	53	2	15800623
Pubmed	Regulation of clock genes.	PER3 PER2	1.36e-05	4	53	2	10487202
Pubmed	Cloning and characterization of rat casein kinase 1epsilon.	PER3 PER2	1.36e-05	4	53	2	10899319
Pubmed	Tissue-intrinsic dysfunction of circadian clock confers transplant arteriosclerosis.	PER3 PER2	1.36e-05	4	53	2	21969583
Pubmed	Prdm16 is crucial for progression of the multipolar phase during neural differentiation of the developing neocortex.	PAX6 PRDM16	1.36e-05	4	53	2	27993981
Pubmed	The circadian clock protein Period 1 regulates expression of the renal epithelial sodium channel in mice.	PER3 PER2	1.36e-05	4	53	2	19587447
Pubmed	Expression of basic helix-loop-helix/PAS genes in the mouse suprachiasmatic nucleus.	PER3 PER2	1.36e-05	4	53	2	10077321
Pubmed	Visualizing and Quantifying Intracellular Behavior and Abundance of the Core Circadian Clock Protein PERIOD2.	PER3 PER2	1.36e-05	4	53	2	27374340
Pubmed	Relationship between APOE, PER2, PER3 and OX2R Genetic Variants and Neuropsychiatric Symptoms in Patients with Alzheimer's Disease.	PER3 PER2	1.36e-05	4	53	2	36901420
Pubmed	Comparison of β-adrenergic and glucocorticoid signaling on clock gene and osteoblast-related gene expressions in human osteoblast.	PER3 PER2	1.36e-05	4	53	2	22217103
Pubmed	The ins and outs of circadian timekeeping.	PER3 PER2	1.36e-05	4	53	2	10508692
Pubmed	Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription.	PER3 PER2	2.27e-05	5	53	2	9856465
Pubmed	EZH2 Mediates epigenetic silencing of neuroblastoma suppressor genes CASZ1, CLU, RUNX3, and NGFR.	CLU RUNX3	2.27e-05	5	53	2	22068036
Pubmed	Disturbance of circadian gene expression in hepatocellular carcinoma.	PER3 PER2	2.27e-05	5	53	2	18444243
Pubmed	FAM209 associates with DPY19L2, and is required for sperm acrosome biogenesis and fertility in mice.	DPY19L2 DPY19L2P2	2.27e-05	5	53	2	34471926
Pubmed	Intercellular coupling confers robustness against mutations in the SCN circadian clock network.	PER3 PER2	2.27e-05	5	53	2	17482552
Pubmed	Control of intracellular dynamics of mammalian period proteins by casein kinase I epsilon (CKIepsilon) and CKIdelta in cultured cells.	PER3 PER2	2.27e-05	5	53	2	11865049
Pubmed	Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice.	PER3 PER2	2.27e-05	5	53	2	12843397
Pubmed	Dimerization and nuclear entry of mPER proteins in mammalian cells.	PER3 PER2	2.27e-05	5	53	2	10837028
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	HOXA11 NKX2-4 PDK3 ZFHX3 POGZ PAX6 RUNX3	2.84e-05	583	53	7	29844126
Pubmed	A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock.	PER3 PER2	3.40e-05	6	53	2	9989497
Pubmed	Molecular bases for circadian clocks.	PER3 PER2	3.40e-05	6	53	2	9988221
Pubmed	Macromolecular Assemblies of the Mammalian Circadian Clock.	PER3 PER2	3.40e-05	6	53	2	28886335
Pubmed	Rhythmic diurnal gene expression in human adipose tissue from individuals who are lean, overweight, and type 2 diabetic.	PER3 PER2	3.40e-05	6	53	2	21411511
Pubmed	Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8.	ABCA4 ABCA7	3.40e-05	6	53	2	12111378
Pubmed	The role of polymorphisms in circadian pathway genes in breast tumorigenesis.	PER3 PER2	3.40e-05	6	53	2	20978934
Pubmed	Phosphorylation of clock protein PER1 regulates its circadian degradation in normal human fibroblasts.	PER3 PER2	3.40e-05	6	53	2	14750904
Pubmed	Fgf receptor signaling plays a role in lens induction.	FGFR1 PAX6	3.40e-05	6	53	2	11714669
Pubmed	Gyrification of the cerebral cortex requires FGF signaling in the mammalian brain.	FGFR1 PAX6	3.40e-05	6	53	2	29132503
Pubmed	Matrix metalloproteinase 2 and 9 dysfunction underlie vascular stiffness in circadian clock mutant mice.	PER3 PER2	3.40e-05	6	53	2	20829506
Pubmed	Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes.	POGZ PAX6	3.40e-05	6	53	2	32103003
Pubmed	Transcription factors Runx1 to 3 are expressed in the lacrimal gland epithelium and are involved in regulation of gland morphogenesis and regeneration.	PAX6 RUNX3	3.40e-05	6	53	2	23532528
Pubmed	mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop.	PER3 PER2	3.40e-05	6	53	2	10428031
Pubmed	Analysis of the molecular pathophysiology of sleep disorders relevant to a disturbed biological clock.	PER3 PER2	4.76e-05	7	53	2	23546644
Pubmed	HDAC3 Is a Master Regulator of mTEC Development.	FOXN1 NCOR1	6.34e-05	8	53	2	27068467
Pubmed	Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock.	PER3 PER2	8.15e-05	9	53	2	14701732
Pubmed	Decapping Enzyme NUDT12 Partners with BLMH for Cytoplasmic Surveillance of NAD-Capped RNAs.	PER3 PER2	8.15e-05	9	53	2	31875550
Pubmed	FGF Signaling Directs the Cell Fate Switch from Neurons to Astrocytes in the Developing Mouse Cerebral Cortex.	FGFR1 PAX6	8.15e-05	9	53	2	31175212
Pubmed	Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder.	PER3 PER2	1.02e-04	10	53	2	16528748
Pubmed	Developmental dynamics of two bipotent thymic epithelial progenitor types.	FOXN1 FGFR1	1.02e-04	10	53	2	35614226
Pubmed	Importin alpha/beta mediates nuclear transport of a mammalian circadian clock component, mCRY2, together with mPER2, through a bipartite nuclear localization signal.	PER3 PER2	1.02e-04	10	53	2	15689618
Pubmed	Testing the circadian gene hypothesis in prostate cancer: a population-based case-control study.	PER3 PER2	1.02e-04	10	53	2	19934327
Pubmed	Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.	CLU ABCA7	1.24e-04	11	53	2	21460841
Pubmed	The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis.	PER2 ZFHX3	1.24e-04	11	53	2	26232227
Pubmed	A mouse model for embryonal tumors with multilayered rosettes uncovers the therapeutic potential of Sonic-hedgehog inhibitors.	FOXN1 PAX6	1.24e-04	11	53	2	28892064
Pubmed	Fibroblast growth factor receptor 1 (Fgfr1) is not essential for lens fiber differentiation in mice.	FGFR1 PAX6	1.24e-04	11	53	2	16446698
Pubmed	Oxidative stress regulates progenitor behavior and cortical neurogenesis.	PAX6 PRDM16	1.24e-04	11	53	2	32041791
Pubmed	Patterning of the basal telencephalon and hypothalamus is essential for guidance of cortical projections.	NKX2-4 PAX6	1.49e-04	12	53	2	11830575
Pubmed	Brain-specific deletion of histone variant H2A.z results in cortical neurogenesis defects and neurodevelopmental disorder.	NKX2-4 PAX6	1.49e-04	12	53	2	29294103
Pubmed	Hoxa11 and Hoxd11 regulate chondrocyte differentiation upstream of Runx2 and Shox2 in mice.	HOXA11 RUNX3	1.49e-04	12	53	2	22916278
Cytoband	11p13	C11orf91 PAX6	1.93e-03	56	53	2	11p13
Cytoband	Ensembl 112 genes in cytogenetic band chr11p13	C11orf91 PAX6	2.60e-03	65	53	2	chr11p13
GeneFamily	ATP binding cassette subfamily A	ABCA4 ABCA7	2.90e-04	14	33	2	805
GeneFamily	Olfactory receptors, family 4	OR4C11 OR4C13 OR4B1	1.66e-03	129	33	3	151
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZFHX3 DENND2B PCDH18 BEGAIN PDZD2	1.88e-06	175	52	5	fa16c6ba08dc0cc22e8cf049db0577811d080df6
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	BNC2 ABCA4 MKLN1 FGFR1 PDZD2	2.61e-06	187	52	5	c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	BNC2 ABCA4 MKLN1 FGFR1 PDZD2	2.68e-06	188	52	5	af740fa78542438fdff627ea1f74f4eee43316be
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZFHX3 DENND2B PCDH18 BEGAIN PDZD2	2.97e-06	192	52	5	430ef714bf2544d32f3fd96a55af010f79aa9be0
ToppCell	PND07-28-samps-Lymphocyte-B_cell-B_cell_2\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	ARHGAP15 CACNA1H RUNX3 KMO	1.99e-05	137	52	4	2544d1256f11da6e3bad24a871b2253e0ab20d01
ToppCell	PND07-28-samps-Lymphocyte-B_cell\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	ARHGAP15 CACNA1H RUNX3 KMO	1.99e-05	137	52	4	874e2eaa7846a2832f46b77c726d79f220a4a1cd
ToppCell	LPS-IL1RA+antiTNF-Myeloid-Dendritic_cells-Monocytes-Macrophages\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PLB1 ARHGAP15 RUNX3 KMO	2.55e-05	146	52	4	b76110b159acd27a2c8d6a9f98336608ace1ec12
ToppCell	facs-Brain_Myeloid-Cerebellum-3m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP15 FGFR1 RUNX3 KMO	3.56e-05	159	52	4	323cb4a2416d2e6bff0a3f225d2edeae9ab7dc76
ToppCell	nucseq-Immune-Hematopoietic-Granulocytic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	BNC2 ARHGAP15 CACNA1H BEGAIN	4.12e-05	165	52	4	37615622c736e43260c38016e7c9e565ac97a3e8
ToppCell	nucseq-Immune-Hematopoietic-Granulocytic-Mast/Basophil\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	BNC2 ARHGAP15 CACNA1H BEGAIN	4.12e-05	165	52	4	640bb71e74a61df2fcb01ceeabe4c493ef836b21
ToppCell	nucseq-Immune-Hematopoietic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	BNC2 ARHGAP15 CACNA1H BEGAIN	4.12e-05	165	52	4	f3df74b5763130c71c0a482a3a23f6b22acc2892
ToppCell	Control-Mast_cells\|Control / group, cell type (main and fine annotations)	BNC2 ARHGAP15 CACNA1H BEGAIN	4.52e-05	169	52	4	fdb9abca1d0f4fdc32dd8ac6231651ef34aa5afb
ToppCell	Control-Mast_cells-Mast_cells\|Control / group, cell type (main and fine annotations)	BNC2 ARHGAP15 CACNA1H BEGAIN	4.62e-05	170	52	4	c80f6d29096c372da95a8407f402349ff1bb7018
ToppCell	droplet-Lung-1m-Hematologic-myeloid-myeloid_dendritic_cell-myeloid_dendritic_type_1\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DPY19L1 FGFR1 RUNX3 KMO	4.73e-05	171	52	4	38a05b5ec8ef8f09a2399994c6b4b9a707918ec1
ToppCell	droplet-Fat-Scat-21m-Endothelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCDHGA6 PRDM16 DENND2B PDZD2	4.95e-05	173	52	4	f13124b4cf2ac1dc2895f90f5487d6ac681b0ba4
ToppCell	3'_v3-blood-Mast-Mast_cell_granulo-myelo\|blood / Manually curated celltypes from each tissue	DPY19L2 CLU KMO ZNF367	5.29e-05	176	52	4	d421b6b8e13894dbcf29548c0a6516c3dee8f9b1
ToppCell	COVID-19-Heart-Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	ARHGAP15 ZFHX3 CACNA1H PDZD2	6.29e-05	184	52	4	21790cdfa3b4036ad413fd44b94e31563116f25f
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZFHX3 CACNA1H PCDH18 PDZD2	6.29e-05	184	52	4	327ff3ac8d2fecdd5d242bdc34f0dfdb1c59a68b
ToppCell	COPD-Myeloid-Mast\|COPD / Disease state, Lineage and Cell class	BNC2 DPY19L1 CLU CACNA1H	6.56e-05	186	52	4	def6f0f284acc2154738574c8c5d3d2a5ef1f208
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABCA4 MKLN1 FGFR1 PDZD2	6.56e-05	186	52	4	f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZFHX3 PCDH18 BEGAIN PDZD2	7.12e-05	190	52	4	106862ef44fcaa0971c3ba0147d13eb08015ca77
ToppCell	COPD-Myeloid-Mast\|Myeloid / Disease state, Lineage and Cell class	BNC2 DPY19L1 CLU CACNA1H	7.12e-05	190	52	4	379dbac19110b76079a7a53209569e060a852acb
ToppCell	droplet-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CLU NYNRIN FGFR1 PRDM16	7.12e-05	190	52	4	3cf464664d6aa22b212e60b70885953887e92483
ToppCell	droplet-Pancreas-Endocrine\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCOR1 UBR4 PAX6 PRRC2B	7.41e-05	192	52	4	0dfd1e9896c34aee0f842f8de5d0e3af62a15f68
ToppCell	droplet-Pancreas-Endocrine-21m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCOR1 UBR4 PAX6 PRRC2B	7.72e-05	194	52	4	3a3ecedcdc7691cf21775818b598208fcb980c29
ToppCell	IPF-Stromal-Pericyte\|Stromal / Disease state, Lineage and Cell class	DPY19L2 ARHGAP15 CACNA1H PDZD2	7.72e-05	194	52	4	3892b188f424ffb80f3c75a1b6709a21c1e1601d
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCOR1 UBR4 PAX6 PRRC2B	7.72e-05	194	52	4	0b023de48ed8a550d169bbe954881eb04bf4f981
ToppCell	10x3'2.3-week_14-16-Mesenchymal_osteo-stroma-osteoblast\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	CLU FGFR1 PCDH18 PDZD2	8.03e-05	196	52	4	760885dc608c82768fe0decd63ed9fda8315f453
ToppCell	Non-neuronal-Non-dividing-Radial_Glia-tRG\|World / Primary Cells by Cluster	CLU PAX6 PRDM16 DENND2B	8.19e-05	197	52	4	61749ccafeb938c310cff1de5ff924a1c794325a
ToppCell	Non-neuronal-Non-dividing-Radial_Glia-tRG-25\|World / Primary Cells by Cluster	CLU PAX6 PRDM16 DENND2B	8.19e-05	197	52	4	9d4ffa3680f92c91d0a081f9a8ec5ebfec6bdcf6
ToppCell	Non-neuronal-Dividing-Radial_Glia-vRG-20\|World / Primary Cells by Cluster	CLU PAX6 PRDM16 DENND2B	8.35e-05	198	52	4	bce0bc1e3f2257e0f42a1fa6e5b57cf71e4514ba
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	BNC2 CLU ZFHX3 FGFR1	8.51e-05	199	52	4	abd6117f8a3d7e798d8471c16d97b34aaf50fc9c
ToppCell	Parenchymal-10x5prime-Stromal-Peri/Epineurial_-NAF_epineurial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	BNC2 TMEM232 NYNRIN PDZD2	8.68e-05	200	52	4	36de49593cf6ff1c9229fcceb150c1d68658a360
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Radial_glial\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	CLU FGFR1 PAX6 DENND2B	8.68e-05	200	52	4	ed4a41cb6782541d8fc928aaa12cf03bc1c630a2
Drug	Rapamycin; Up 200; 0.1uM; HL60; HT_HG-U133A	HOXA11 PER3 UBR4 MARCHF6 ZFHX3 DENND2B BEGAIN	3.59e-07	197	53	7	2667_UP
Drug	Cloxacillin sodium salt [642-78-4]; Up 200; 8.8uM; PC3; HT_HG-U133A	PER3 CLU PDK3 ZFHX3 FGFR1 RUNX3	6.00e-06	195	53	6	2126_UP
Drug	Vitexin [3681-93-4]; Down 200; 9.2uM; PC3; HT_HG-U133A	FAM120C BTD NYNRIN POGZ KMO PDZD2	6.36e-06	197	53	6	4588_DN
Drug	sodium bisulfite	PSMB4 CACNA1H FGFR1 RUNX3 PRDM16	2.93e-05	154	53	5	CID000024437
Drug	lomustine; Down 200; 100uM; PC3; HT_HG-U133A	BNC2 PER2 PAX6 ABCA7 DENND2B	6.16e-05	180	53	5	7094_DN
Drug	AC1MQ5W8	CACNA1H PAX6	7.93e-05	6	53	2	CID003396482
Drug	Ald1.1-H_000455; Up 200; 10uM; PC3; HT_HG-U133A	PER2 FAM120C FGFR1 POGZ KMO	8.16e-05	191	53	5	7547_UP
Drug	DNA-PK Inhibitor III; Up 200; 1uM; PC3; HT_HG-U133A	CLU FAM120C FGFR1 RUNX3 ABCA7	8.36e-05	192	53	5	7548_UP
Drug	Primaquine diphosphate [63-45-6]; Down 200; 8.8uM; PC3; HT_HG-U133A	HOXA11 PDK3 ABCA7 KMO PRRC2B	8.78e-05	194	53	5	4263_DN
Drug	Meclofenamic acid sodium salt monohydrate [6385-02-0]; Down 200; 11.8uM; MCF7; HT_HG-U133A	FAM120C NYNRIN CACNA1H ABCA7 BEGAIN	9.22e-05	196	53	5	2291_DN
Drug	Idoxuridine [54-42-2]; Up 200; 11.2uM; MCF7; HT_HG-U133A	ADGB PER3 NYNRIN ABCA7 DENND2B	9.22e-05	196	53	5	4785_UP
Drug	Methylprednisolone, 6-alpha [83-43-2]; Up 200; 10.6uM; PC3; HT_HG-U133A	HOXA11 AGO4 PER3 RUNX3 KMO	9.22e-05	196	53	5	7137_UP
Drug	Vinpocetine [42971-09-5]; Up 200; 11.4uM; MCF7; HT_HG-U133A	ADGB PER2 CACNA1H RUNX3 KMO	9.44e-05	197	53	5	3174_UP
Drug	Tolbutamide [64-77-7]; Down 200; 14.8uM; MCF7; HT_HG-U133A	PER2 FAM120C CACNA1H FGFR1 DENND2B	9.44e-05	197	53	5	3886_DN
Drug	Harmalol hydrochloride dihydrate [6028-07-5]; Up 200; 14.6uM; MCF7; HT_HG-U133A	BTD NYNRIN FGFR1 RUNX3 KMO	9.44e-05	197	53	5	5495_UP
Drug	Hydroxytacrine maleate (R,S) [118909-22-1]; Up 200; 12.2uM; MCF7; HT_HG-U133A	BTD MARCHF6 CACNA1H ABCA7 PRRC2B	9.44e-05	197	53	5	3292_UP
Drug	Praziquantel [55268-74-1]; Down 200; 12.8uM; PC3; HT_HG-U133A	CLU PDK3 BTD POGZ PRRC2B	9.44e-05	197	53	5	5874_DN
Drug	Dipyrone [5907-38-0]; Up 200; 12uM; MCF7; HT_HG-U133A	HOXA11 AGO4 NYNRIN FGFR1 PDZD2	9.67e-05	198	53	5	3929_UP
Drug	ICI182,780; Down 200; 1uM; PC3; HT_HG-U133A	BTD MKLN1 FGFR1 PAX6 ABCA7	9.67e-05	198	53	5	7096_DN
Drug	Isradipine [75695-93-1]; Up 200; 10.8uM; MCF7; HT_HG-U133A	ARHGAP15 CACNA1H FGFR1 BEGAIN PDZD2	9.67e-05	198	53	5	6508_UP
Drug	Etidronic acid, disodium salt [7414-83-7]; Up 200; 16uM; MCF7; HT_HG-U133A	NYNRIN MARCHF6 PAX6 PRDM16 ABCA7	9.67e-05	198	53	5	3325_UP
Drug	Ergocryptine-alpha [511-09-1]; Down 200; 7uM; PC3; HT_HG-U133A	PDK3 FGFR1 ABCA7 DENND2B KMO	9.90e-05	199	53	5	4552_DN
Drug	Tetrahydroalstonine [6474-90-4]; Up 200; 11.4uM; PC3; HT_HG-U133A	HOXA11 PER3 PER2 MARCHF6 FGFR1	9.90e-05	199	53	5	5728_UP
Drug	Metoclopramide monohydrochloride [7232-21-5]; Up 200; 11.8uM; MCF7; HT_HG-U133A	HOXA11 AGO4 ABCA7 KMO PDZD2	9.90e-05	199	53	5	3625_UP
Drug	Pentylenetetrazole [54-95-5]; Up 200; 29uM; PC3; HT_HG-U133A	PDK3 BTD ZFHX3 FGFR1 RUNX3	9.90e-05	199	53	5	2092_UP
Drug	mono-(2-ethylhexyl)phthalate	NCOR1 PLB1 ABCA4 PER3 PER2 DPY19L1 ABCA7 KMO	1.31e-04	658	53	8	ctd:C016599
Drug	Antirobe	CLU PDK3 DENND2B	1.47e-04	44	53	3	CID000002786
Disease	Advanced Sleep-Phase Syndrome, Familial	PER3 PER2	8.78e-06	3	51	2	C1858496
Disease	advanced sleep phase syndrome (is_implicated_in)	PER3 PER2	1.75e-05	4	51	2	DOID:0050628 (is_implicated_in)
Disease	Eczema	BNC2 ARHGAP15 FGFR1 RUNX3 PRDM16	1.96e-04	310	51	5	HP_0000964
Disease	Giant Cell Glioblastoma	NCOR1 FGFR1 RUNX3	4.20e-04	84	51	3	C0334588
Disease	Eczema, allergic rhinitis	BNC2 ARHGAP15 RUNX3 PRDM16	5.24e-04	215	51	4	EFO_0005854, HP_0000964
Disease	heart failure, diabetes mellitus, stroke, atrial fibrillation, mortality, coronary artery disease, cancer	ZFHX3 BSX	5.46e-04	20	51	2	EFO_0000275, EFO_0000400, EFO_0000712, EFO_0001645, EFO_0003144, EFO_0004352, MONDO_0004992
Disease	inflammatory bowel disease (implicated_via_orthology)	RUNX3 PDZD2	8.57e-04	25	51	2	DOID:0050589 (implicated_via_orthology)
Disease	allergic disease	PLB1 ARHGAP15 FGFR1 RUNX3	1.03e-03	258	51	4	MONDO_0005271
Disease	Myeloid Leukemia, Chronic	PER3 PER2	1.15e-03	29	51	2	C0023473
Disease	D dimer measurement	ABCA4 OR4B1	1.24e-03	30	51	2	EFO_0004507
Disease	caudate nucleus volume	ZFHX3 PRDM16	1.24e-03	30	51	2	EFO_0004830

Protein segments in the cluster

Peptide	Gene	Start	Entry
MPETRYLFPITTSFT	ATP6V1FNB	121	A0A1B0GUX0
YFPEQPSSSRLYVPM	ABHD13	66	Q7L211
PMMYPASFLFDVPST	ABCA4	1776	P78363
TMSPYPAETFRFPAS	BEGAIN	371	Q9BUH8
LEISSPFLNYRMTPF	ADGB	506	Q8N7X0
PFLNYRMTPFTIPTE	ADGB	511	Q8N7X0
PFYRSLLTPGEMVSP	BNC2	571	Q6ZN30
PYFLTTSGMPVPALF	BSX	81	Q3C1V8
SMRYTPVGRSFFSPP	AGO4	161	Q9HCK5
VYPFMRSLMESPFPA	DENND2B	826	P78524
TPLMYPASFFFSVPS	ABCA7	1631	Q8IZY2
FYRIPSTPDSFMDPA	PSMB4	21	P28070
LPSPSSDYRSNMFIP	PCDH18	936	Q9HCL0
ALTNTYSALPPMPSF	PAX6	321	P26367
AAPSSRFPLMEVYDP	PCDHGA6	146	Q9Y5G7
PDPRYSSISRFMGPS	NKX2-4	141	Q9H2Z4
MSLKPFTYPFPETRF	MAJIN	1	Q3KP22
APVMAFMLPSYSFPS	PER2	901	O15055
FPYLDTFMTVFLPDP	PER3	841	P56645
PRPATRTYSMPAQFS	PDZD2	2216	O15018
MWTPPLRESFSYPFL	DPY19L1	206	Q2PZI1
FTPIYSPDMPSRLPI	MARCHF6	61	O60337
PSFLPQTPSSRPMTY	HOXA11	31	P31270
PCIFIYTRPPTTFPM	OR4C11	251	Q6IEV9
TITASPSLRSPMYFF	OR4C13	46	Q8NGP0
VMWTPPLRESFSYPF	DPY19L2	291	Q6NUT2
PSTFIPLYTMVTFSR	KMO	391	O15229
MPLDQYSPSFPDTRS	FGFR1	771	P11362
ERMFLSFPTTKTYFP	HBA1;	31	P69905
PMVPSLYPVSLYSRA	FAM120C	916	Q9NX05
TRTSIYPFLDFMPSP	BTD	121	P43251
SLPNDSYMFRPVVPA	CACNA1H	1926	O95180
VMWTPPLRESFSYPF	DPY19L2P2	101	Q6ZN68
MPRFFQVLPPFSDLS	NYNRIN	1291	Q9P2P1
ISVFYTMLPPTFNPI	OR14A16	271	Q8NHC5
PAIFLYMRPSSTFTE	OR4B1	251	Q8NGF8
PTLTESRFPDPRMHY	RUNX3	256	Q13761
FDTLVNFFPDSMTPP	MKLN1	711	Q9UL63
LYSAFMELEPTPPTA	FOXN1	616	O15353
APLTSSMDPLPVFLY	POGZ	716	Q7Z3K3
AKPSPFFMDPIYSRV	PRDM16	856	Q9HAZ2
SSRSMFIPYREGPIP	PRR23B	181	Q6ZRT6
ITFPPRPYNSASMSP	NCOR1	1686	O75376
KMFFRELPEPLFPYS	ARHGAP15	356	Q53QZ3
EFYLAPEPFSMPSLL	RNF217	226	Q8TC41
SDIIRYFSPSVPMPV	PLB1	111	Q6P1J6
FNYMYSTAPRPSLEP	PDK3	301	Q15120
VRSLMPFSPYEPLNF	CLU	226	P10909
PYPFTPFMTVSNDLP	C11orf53	181	Q8IXP5
PTMSQRSAPPLYFPS	C11orf91	11	Q3C1V1
PSVSEIPMFPYPDFF	TMEM232	571	C9JQI7
MDPRITPTRTPVDFY	PRRC2B	681	Q5JSZ5
MDQYVSTAPPRFPIA	SMIM21	1	Q3B7S5
LIPTSPGFSDFMVYP	ZNF367	56	Q7RTV3
YFTRSPPSLHMSLFP	VN1R3	246	Q9BXE9
SSPPDMSPFFLRQYV	UBR4	3131	Q5T4S7
PNFTMEKFLDPSRPY	ZFHX3	1531	Q15911