Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	epithelial cell morphogenesis	COL18A1 SIPA1 JMJD1C PALLD	5.06e-06	49	48	4	GO:0003382
GeneOntologyBiologicalProcess	epithelial cell development	COL18A1 TJP2 SIPA1 ADAMTSL4 JMJD1C PALLD	3.61e-05	269	48	6	GO:0002064
Domain	ADAM_spacer1	ADAMTS5 ADAMTSL4	1.45e-03	23	46	2	IPR010294
Domain	ADAM_spacer1	ADAMTS5 ADAMTSL4	1.45e-03	23	46	2	PF05986
Domain	Kinesin-like_fam	KIF26A KIF1C	5.03e-03	43	46	2	IPR027640
Domain	KINESIN_MOTOR_1	KIF26A KIF1C	5.26e-03	44	46	2	PS00411
Domain	-	KIF26A KIF1C	5.26e-03	44	46	2	3.40.850.10
Domain	Kinesin_motor_dom	KIF26A KIF1C	5.26e-03	44	46	2	IPR001752
Domain	Kinesin	KIF26A KIF1C	5.26e-03	44	46	2	PF00225
Domain	KISc	KIF26A KIF1C	5.26e-03	44	46	2	SM00129
Domain	KINESIN_MOTOR_2	KIF26A KIF1C	5.26e-03	44	46	2	PS50067
Domain	TSP_1	ADAMTS5 ADAMTSL4	1.05e-02	63	46	2	PF00090
Domain	TSP1	ADAMTS5 ADAMTSL4	1.12e-02	65	46	2	SM00209
Domain	TSP1_rpt	ADAMTS5 ADAMTSL4	1.12e-02	65	46	2	IPR000884
Domain	TSP1	ADAMTS5 ADAMTSL4	1.12e-02	65	46	2	PS50092
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	GTSE1 DNAJB6 TJP2 PAN3 CAMSAP1 PALLD USP6NL CRTC2 KIF1C	4.01e-06	861	51	9	36931259
Pubmed	Modulation of the transactivation function and stability of Krüppel-like zinc finger protein Gli-similar 3 (Glis3) by Suppressor of Fused.	GLI1 GLIS3	6.32e-06	3	51	2	21543335
Pubmed	Human telomerase reverse transcriptase (hTERT) synergistic with Sp1 upregulate Gli1 expression and increase gastric cancer invasion and metastasis.	GLI1 TERT	6.32e-06	3	51	2	34601664
Pubmed	Telomere dysfunction drives aberrant hematopoietic differentiation and myelodysplastic syndrome.	SRSF2 TERT	6.32e-06	3	51	2	25965571
Pubmed	Functional analysis of the zinc finger and activation domains of Glis3 and mutant Glis3(NDH1).	GLI1 GLIS3	6.32e-06	3	51	2	18263616
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	ERBB3 TJP2 BUD13 CAMSAP1 JMJD1C PALLD	1.46e-05	361	51	6	26167880
Pubmed	Kruppel-like factor 5 controls villus formation and initiation of cytodifferentiation in the embryonic intestinal epithelium.	GLI1 EPS8L3 GRHL3	2.23e-05	37	51	3	23266329
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	GTSE1 NFKBIL1 GLIS3 CAMSAP1 NYAP1 CRTC2	3.88e-05	430	51	6	35044719
Pubmed	Structure, chromosomal localization, and expression analysis of the mouse inhibin/activin beta C (Inhbc) gene.	ERBB3 GLI1	4.41e-05	7	51	2	8838799
Pubmed	Gcm1, a mammalian homolog of Drosophila glial cells missing.	ERBB3 GLI1	5.87e-05	8	51	2	8814290
Pubmed	Altered neural cell fates and medulloblastoma in mouse patched mutants.	ERBB3 GLI1	7.54e-05	9	51	2	9262482
Pubmed	Proviral integrations at the Evi5 locus disrupt a novel 90 kDa protein with homology to the Tre2 oncogene and cell-cycle regulatory proteins.	ERBB3 GLI1	7.54e-05	9	51	2	9070650
Pubmed	Regulation of Chondrocyte Survival in Mouse Articular Cartilage by p63.	ADAMTS5 BBC3	7.54e-05	9	51	2	27792866
Pubmed	CD spectra show the relational style between Zic-, Gli-, Glis-zinc finger protein and DNA.	GLI1 GLIS3	9.42e-05	10	51	2	18298960
Pubmed	Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning.	RAB34 GLI1	1.15e-04	11	51	2	17442700
Pubmed	Combined genetic-pharmacologic inactivation of tightly linked ADAMTS proteases in temporally specific windows uncovers distinct roles for versican proteolysis and glypican-6 in cardiac development.	GLI1 ADAMTS5	1.15e-04	11	51	2	38750698
Pubmed	Disruption of murine Adamtsl4 results in zonular fiber detachment from the lens and in retinal pigment epithelium dedifferentiation.	COL18A1 ADAMTSL4	1.38e-04	12	51	2	26405179
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	GTSE1 CAMSAP1 JMJD1C PALLD	1.56e-04	184	51	4	32908313
Pubmed	A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells.	SRSF2 GLI1 TJP2	1.72e-04	73	51	3	22094256
Pubmed	Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors.	PSMF1 KCNA3 GTSE1 MCM9 CAMSAP1	1.81e-04	359	51	5	35559673
Pubmed	SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.	DNAJB6 TJP2 BUD13 CIT USP6NL	2.30e-04	378	51	5	34315543
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	GTSE1 DNAJB6 TJP2 PAN3 CAMSAP1 ELL KIF1C	2.36e-04	853	51	7	28718761
Pubmed	Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1/2 activation, and to attenuate trabecular cardiomyocyte proliferation.	ERBB3 ADAMTS5	2.83e-04	17	51	2	22183742
Pubmed	Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ANKRD6 CIT PALLD	4.60e-04	102	51	3	10231032
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	RAB34 GLI1 GLIS3 JMJD1C CRTC2	5.47e-04	457	51	5	32344865
Pubmed	Kruppel-like factor 5 is required for formation and differentiation of the bladder urothelium.	GLI1 GRHL3	5.70e-04	24	51	2	21803035
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	KCNA3 DNAJB6 CAMSAP1 JMJD1C PALLD USP6NL	5.76e-04	708	51	6	39231216
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	CPEB4 CAMSAP1 JMJD1C USP6NL	6.04e-04	263	51	4	34702444
Pubmed	GLIS3 expression in the thyroid gland in relation to TSH signaling and regulation of gene expression.	COL18A1 GLIS3	6.70e-04	26	51	2	38281222
Pubmed	A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response.	TJP2 CIT PALLD	7.04e-04	118	51	3	30979931
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	SRSF2 PRICKLE3 GTSE1 DNAJB6 TJP2 PAN3 CRTC2	7.61e-04	1038	51	7	26673895
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CPEB4 ANKRD6 JMJD1C PALLD KIF1C	7.70e-04	493	51	5	15368895
Pubmed	Primary cilia and Gli3 activity regulate cerebral cortical size.	GLI1 TJP2	8.35e-04	29	51	2	21976438
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	SRSF2 GTSE1 TJP2 PALLD KIF1C	8.43e-04	503	51	5	16964243
Pubmed	Interactome Analysis Reveals a Novel Role for RAD6 in the Regulation of Proteasome Activity and Localization in Response to DNA Damage.	PSMF1 NFKBIL1 TJP2	9.53e-04	131	51	3	28031328
Pubmed	Embryonic forebrain transcriptome of mice with polyalanine expansion mutations in the ARX homeobox gene.	KCNA3 GABBR2	9.54e-04	31	51	2	27798109
Pubmed	Voltage-gated potassium channel genes are clustered in paralogous regions of the mouse genome.	KCNA3 GLI1	9.54e-04	31	51	2	8034307
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	PRICKLE3 ZNF764 GLIS3 TERT RCOR2 ZNF646	1.14e-03	808	51	6	20412781
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	CPEB4 NFKBIL1 DNAJB6 BUD13 SIPA1 RCOR2 ZNF646	1.16e-03	1116	51	7	31753913
Pubmed	CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells.	BBC3 CRTC2	1.22e-03	35	51	2	23716698
Pubmed	Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens.	ERBB3 GLI1	1.29e-03	36	51	2	9344654
Pubmed	All kinesin superfamily protein, KIF, genes in mouse and human.	KIF26A KIF1C	1.36e-03	37	51	2	11416179
Pubmed	Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.	ERBB3 GLIS3	1.36e-03	37	51	2	19430480
Pubmed	Lysine acetylation targets protein complexes and co-regulates major cellular functions.	SRSF2 KIF1C	1.43e-03	38	51	2	19608861
Cytoband	1p13.3	KCNA3 EPS8L3	2.71e-03	69	51	2	1p13.3
GeneFamily	Kinesins\|Pleckstrin homology domain containing	KIF26A KIF1C	2.81e-03	46	31	2	622
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF142 GLI1 ZNF764 GLIS3 ZNF646	7.02e-03	718	31	5	28
ToppCell	AT1-AT2_cells-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	COL18A1 EPS8L3 ADAMTS5 GRHL3 GABBR2 NYAP1	5.85e-08	180	51	6	3c7b2033821f9e34e2924bd8655f566edcbcc7d3
Disease	complex cortical dysplasia with other brain malformations (is_implicated_in)	KIF26A CAMSAP1	1.68e-05	4	50	2	DOID:0090131 (is_implicated_in)
Disease	erythrocyte measurement	ZNF142 CPEB4 BUD13 ELL	9.45e-04	257	50	4	EFO_0005047
Disease	triacylglycerol 54:3 measurement	BUD13 GABBR2	1.27e-03	31	50	2	EFO_0010421

Protein segments in the cluster

Peptide	Gene	Start	Entry
NRRRRHSPPHPPRPS	ERBB3	1201	P21860
SPRRARHDTPDPSPL	BUD13	151	Q9BRD0
PPHKLRRLPPTSARH	SLC4A3	91	P48751
STHLPPRLEPPRAHD	ELL	381	P55199
APRTRPAPLRHHPRA	ADAMTSL4	241	Q6UY14
EPPGHPHPLAQRRRS	ADAMTS5	56	Q9UNA0
HPAARCLPLRPHRPT	BBC3	86	Q96PG8
PHLRPFPASSHPRTP	CAMSAP1	1131	Q5T5Y3
RHHPRHSYPRSPPAD	CCER1	151	Q8TC90
GPSHPREPSTPHRYR	CIT	1946	O14578
RHRCSSPPPPHEFRA	ANKRD6	376	Q9Y2G4
RPALAAPRHSARPGP	RCOR2	491	Q8IZ40
SHIPVRPSSAEPHRP	JMJD1C	921	Q15652
LRPARPTSPPAHSHR	COL18A1	1561	P39060
PRPLPRHTSAREPSA	EPS8L3	206	Q8TE67
PARRPPSPRRSHHPR	KIF1C	1016	O43896
SLLRSPPPPSARHRA	KCNA3	6	P22001
PPHLRPFHPRTVALD	KIF26A	751	Q9ULI4
ASHRAAAPPRLLPPL	GLI1	981	P08151
PPPLHRACARHDAPA	NFKBIL1	66	Q9UBC1
TRAPGPPHSAHALPR	GTSE1	181	Q9NYZ3
SPRSPSGHPHVRRPR	PALLD	1101	Q8WX93
RSPPPRAPSRRRHHH	PRICKLE3	501	O43900
PHTSPAPRRRSHTPN	PAN3	351	Q58A45
KPPRPASLLRHAPHC	DNAJB6	261	O75190
ETSLLHPRLSRHPPP	GRHL3	566	Q8TE85
PGASPHHRRVPLSPL	CRTC2	421	Q53ET0
RFAPSAPSPHHISPR	GLIS3	611	Q8NEA6
APSPHHISPRRVPAP	GLIS3	616	Q8NEA6
APHSAPLRPPRELHA	C19orf73	31	Q9NVV2
PTASPRHRHVPPSFR	GABBR2	921	O75899
RSPASPHPPPFTHRN	CPEB4	251	Q17RY0
VDPLRIPPHHPHTSR	PSMF1	166	Q92530
QPHALPPHAHRRPAS	NYAP1	291	Q6ZVC0
PPHAHRRPASALPSR	NYAP1	296	Q6ZVC0
PPPHLEPNRSTSRKH	MCM9	716	Q9NXL9
RDPPPAHRAHPRHPR	MTCH1	41	Q9NZJ7
AHRAHPRHPRPAAQP	MTCH1	46	Q9NZJ7
PDSHHSRRGPPPRRY	SRSF2	96	Q01130
PPKSPTRDTPHAAHR	NKPD1	546	Q17RQ9
RPPTPASPRARAHSH	SIPA1	61	Q96FS4
SRPARPAPLSHPTAR	SHISA8	331	B8ZZ34
PPPAHRHRRRGSPTR	SPEM1	106	Q8N4L4
SPRHALYPPSPRKHA	USP6NL	576	Q92738
SREHPHSRSPSPEPR	TJP2	286	Q9UDY2
LPPSRHPSRRGPRRH	TYMSOS	86	Q8TAI1
THAPEGRRRHRPPRP	ZNF646	96	O15015
KPTTPPENRPRHFHS	ERVH48-1	141	M5A8F1
RRHPTAAPARGPRPH	ZNF142	1156	P52746
FSHRFPSPLAPRRSP	RNASEK	21	Q6P5S7
CSRPHRAPSPAAPSR	WWC2-AS2	21	Q96NR7
ATQARPPPHASGPRR	TERT	181	O14746
RQHHAGPPSTSRPPR	TERT	301	O14746
SSGPLQARPRPRPHS	nan	231	Q6ZQT7
HRGRPSLCAHPPVPR	ZNF764	156	Q96H86
PPRHLRLPGAPDRHR	RAB34	181	P0DI83