Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcesscell-cell adhesion via plasma-membrane adhesion molecules

MAG DCHS2 HMCN1 DSG1 PCDH15 MDGA1 WNK1 CDH15

1.80e-05313758GO:0098742
DomainRFX1_trans_act

RFX2 RFX3

4.39e-053722IPR007668
DomainRFX1_trans_act

RFX2 RFX3

4.39e-053722PF04589
DomainCadherin

KIAA0319 DCHS2 DSG1 PCDH15 CDH15

9.23e-05118725IPR002126
Domain-

RBM27 RBM26

1.45e-0457221.20.1390.10
DomainPWI

RBM27 RBM26

1.45e-045722PF01480
DomainPWI_dom

RBM27 RBM26

1.45e-045722IPR002483
DomainZnF_U1

TUT7 CIZ1 ZNF407

1.87e-0429723SM00451
DomainZnf_U1

TUT7 CIZ1 ZNF407

1.87e-0429723IPR003604
DomainMYB_LIKE

TRERF1 BDP1 EP400

4.21e-0438723PS50090
DomainRFX_DNA_binding

RFX2 RFX3

5.18e-049722PF02257
DomainDNA-bd_RFX

RFX2 RFX3

5.18e-049722IPR003150
DomainRFX_DBD

RFX2 RFX3

5.18e-049722PS51526
DomainCadherin_CS

DCHS2 DSG1 PCDH15 CDH15

8.32e-04109724IPR020894
DomainSANT

TRERF1 BDP1 EP400

9.45e-0450723SM00717
DomainCADHERIN_1

DCHS2 DSG1 PCDH15 CDH15

9.52e-04113724PS00232
DomainCadherin

DCHS2 DSG1 PCDH15 CDH15

9.52e-04113724PF00028
DomainCADHERIN_2

DCHS2 DSG1 PCDH15 CDH15

9.84e-04114724PS50268
Domain-

DCHS2 DSG1 PCDH15 CDH15

9.84e-041147242.60.40.60
DomainCA

DCHS2 DSG1 PCDH15 CDH15

1.02e-03115724SM00112
DomainCadherin-like

DCHS2 DSG1 PCDH15 CDH15

1.05e-03116724IPR015919
DomainSANT/Myb

TRERF1 BDP1 EP400

1.06e-0352723IPR001005
DomainEPHD

KMT2A KDM4B

3.22e-0322722PS51805
DomainPkinase

NRBP1 GUCY2C WEE1 AAK1 SIK3 WNK1

3.49e-03381726PF00069
DomainCadherin_cytoplasmic-dom

DSG1 CDH15

4.15e-0325722IPR000233
DomainCadherin_C

DSG1 CDH15

4.15e-0325722PF01049
DomaincEGF

HMCN1 LTBP3

4.49e-0326722IPR026823
DomaincEGF

HMCN1 LTBP3

4.49e-0326722PF12662
DomainHECT

UBR5 HUWE1

4.83e-0327722PF00632
DomainHECTc

UBR5 HUWE1

4.83e-0327722SM00119
DomainHECT_dom

UBR5 HUWE1

4.83e-0327722IPR000569
DomainHECT

UBR5 HUWE1

4.83e-0327722PS50237
DomainCatenin_binding_dom

DSG1 CDH15

5.56e-0329722IPR027397
Domain-

DSG1 CDH15

5.56e-03297224.10.900.10
DomainIg_I-set

MAG HMCN1 DCC MDGA1

6.23e-03190724IPR013098
DomainI-set

MAG HMCN1 DCC MDGA1

6.23e-03190724PF07679
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

TRERF1 PHC3 EP400 WEE1 FNBP4 AAK1 ZBTB40 KMT2A ACIN1 ELF1 HUWE1 EMSY GATAD2B USP19 KDM4B SPICE1

9.72e-12774761615302935
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

TRERF1 SP2 GTF2A1 TSC22D1 TUT7 RBM26 CIZ1 ACIN1 ELF1 MGA RFX2 RFX3 GATAD2B KDM4B

2.17e-09808761420412781
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

KPNA5 EP400 UBR5 LIN54 RBM26 ZBTB40 QRICH1 HUWE1 MGA RFX2 RFX3 EMSY GATAD2B

4.12e-08857761325609649
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

EP400 UBR5 RBM27 WEE1 TUT7 NUP210 FNBP4 NKTR HUWE1 CAPRIN1

4.30e-08440761034244565
Pubmed

MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.

GTF2A1 EP400 RBM27 LIN54 KMT2A ELF1 MGA EMSY GATAD2B

5.73e-0833976930415952
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

PHC3 CSN2 LIN54 CIZ1 ZBTB40 KMT2A ELF1 MGA EMSY GATAD2B KDM4B

8.73e-08608761136089195
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

TRERF1 EP400 RBM27 LIN54 RBM26 KMT2A MGA EMSY

1.34e-0726876833640491
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

NRBP1 UBR5 WEE1 RBM26 SREBF2 ZBTB40 KMT2A NKTR QRICH1 MAML2 WNK1 MGA CAPRIN1 EMSY USP19

1.56e-071327761532694731
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

EP400 RBM27 FNBP4 AAK1 IPO13 MAML2 CEP126 SIK3 INPP5F KDM4B

2.37e-07529761014621295
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

KIAA0319 DOCK4 FRAS1 EP400 UBR5 AVL9 ACIN1 R3HDM2 USP19

2.69e-0740776912693553
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

EP400 RBM27 RBM26 FNBP4 CIZ1 KMT2A ACIN1 HUWE1 MGA EMSY

3.32e-07549761038280479
Pubmed

Human transcription factor protein interaction networks.

TRERF1 SP2 PHC3 ARHGAP32 EP400 RBM27 LIN54 ZBTB40 KMT2A ELF1 R3HDM2 MGA CAPRIN1 EMSY GATAD2B

4.01e-071429761535140242
Pubmed

Identification of proximal SUMO-dependent interactors using SUMO-ID.

SP2 EP400 LIN54 AAK1 QRICH1 MGA CAPRIN1 EMSY GATAD2B

5.56e-0744476934795231
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

TRERF1 EP400 UBR5 RBM27 LIN54 RBM26 ZBTB40 KMT2A ELF1 QRICH1 CAPRIN1 EMSY GATAD2B

7.34e-071103761334189442
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

GTF2A1 PHC3 EP400 DSG1 RBM27 RBM26 AAK1 CIZ1 KMT2A ACIN1 WNK1 EMSY

8.40e-07934761233916271
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

PHC3 EP400 RBM27 LIN54 RBM26 FNBP4 CIZ1 KMT2A ACIN1 MGA EMSY GATAD2B

1.05e-06954761236373674
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

KIAA0319 TRERF1 ARHGAP32 UBR5 AAK1 HUWE1 SIK3 MGA CAPRIN1 EMSY GATAD2B SPICE1

1.16e-06963761228671696
Pubmed

A human MAP kinase interactome.

GTF2A1 ARHGAP32 TSC22D1 CSN2 SREBF2 NKTR SIK3 WNK1 MGA

1.17e-0648676920936779
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

NRBP1 RBM27 RBM26 AAK1 ACIN1 ELF1 HUWE1 WNK1 GATAD2B

1.56e-0650376916964243
Pubmed

G-protein pathway suppressor 2 (GPS2) interacts with the regulatory factor X4 variant 3 (RFX4_v3) and functions as a transcriptional co-activator.

ARHGAP32 RFX2 RFX3

1.63e-061176318218630
Pubmed

Identification and functional characterization of transcriptional activators in human cells.

NRBP1 SP2 PHC3 EP400 CIZ1 MGA GATAD2B KDM4B

2.62e-0639876835016035
Pubmed

Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.

GTF2A1 EP400 RBM27 RBM26 ACIN1 MGA EMSY

2.97e-0628376730585729
Pubmed

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.

DSG1 UBR5 RBM27 MGA GATAD2B SPICE1

3.25e-0618476632908313
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

SP2 PHC3 EP400 RBM27 LIN54 FNBP4 CIZ1 KMT2A ACIN1 NKTR MGA EMSY GATAD2B

4.26e-061294761330804502
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

TRERF1 PHC3 ARHGAP32 EP400 WEE1 MAML2 WNK1 MGA

4.63e-0643076835044719
Pubmed

UBR5 is a novel regulator of WNK1 stability.

UBR5 WNK1

4.71e-06276235442829
Pubmed

First case of B ALL with KMT2A-MAML2 rearrangement: a case report.

KMT2A MAML2

4.71e-06276228535805
Pubmed

A family of RS domain proteins with novel subcellular localization and trafficking.

RBM27 RBM26

4.71e-06276215741184
Pubmed

KMT2A-MAML2 rearrangement emerged and regressed during neuroblastoma therapy without leukemia after 12.8-year follow-up.

KMT2A MAML2

4.71e-06276234550633
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

DOCK4 BDP1 EP400 UBR5 WEE1 LIN54 HUWE1 WNK1 EMSY

5.53e-0658876938580884
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

PHC3 EP400 DSG1 RBM27 AVL9 TUT7 RBM26 FNBP4 AAK1 KMT2A ACIN1 NKTR CAPRIN1

7.93e-061371761336244648
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

EP400 NUP210 RBM26 KMT2A ACIN1 EMSY GATAD2B

1.00e-0534176732971831
Pubmed

BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.

EP400 RBM27 LIN54 KMT2A MGA

1.17e-0513476525452129
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SP2 ARHGAP32 TSC22D1 NUP210 ZNF407 WNK1 MGA GATAD2B

1.25e-0549376815368895
Pubmed

Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element.

RFX2 RFX3

1.41e-05376215024578
Pubmed

An improved Flp deleter mouse in C57Bl/6 based on Flpo recombinase.

GTF2A1 KMT2A

1.41e-05376220506501
Pubmed

Drosophila regulatory factor X is necessary for ciliated sensory neuron differentiation.

RFX2 RFX3

1.41e-05376212403718
Pubmed

The human ZC3H3 and RBM26/27 proteins are critical for PAXT-mediated nuclear RNA decay.

RBM27 RBM26

1.41e-05376231950173
Pubmed

RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins.

RFX2 RFX3

1.41e-0537628289803
Pubmed

Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains.

RFX2 RFX3

1.41e-05376210330134
Pubmed

Ciliogenic RFX transcription factors regulate FGF1 gene promoter.

RFX2 RFX3

1.41e-05376222415835
Pubmed

Interplay of RFX transcription factors 1, 2 and 3 in motile ciliogenesis.

RFX2 RFX3

1.41e-05376232725242
Pubmed

Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells.

PCDH15 CDH15

1.41e-05376217805295
Pubmed

Characterization of MRFAP1 turnover and interactions downstream of the NEDD8 pathway.

EP400 UBR5 HUWE1

1.72e-052376322038470
Pubmed

P300 Interacted With N-Myc and Regulated Its Protein Stability via Altering Its Post-Translational Modifications in Neuroblastoma.

EP400 UBR5 HUWE1

2.23e-052576336708875
Pubmed

The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.

UBR5 RBM27 TUT7 RBM26 AAK1 HUWE1 MGA GATAD2B

2.63e-0554776837267103
Pubmed

Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members.

RFX2 RFX3

2.82e-05476211682486
Pubmed

Differential expression of Rfx1-4 during mouse spermatogenesis.

RFX2 RFX3

2.82e-05476219596083
Pubmed

Taspase1 orchestrates fetal liver hematopoietic stem cell and vertebrae fates by cleaving TFIIA.

GTF2A1 KMT2A

2.82e-05476234156981
Pubmed

The cell proliferation antigen Ki-67 organises heterochromatin.

FRAS1 EP400 ACIN1 QRICH1 MGA RFX3 CAPRIN1

3.27e-0541076726949251
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

TRERF1 PHC3 UBR5 LIN54 HUWE1 INPP5F MGA

3.69e-0541876734709266
Pubmed

The functional interactome landscape of the human histone deacetylase family.

TRERF1 UBR5 ACIN1 HUWE1 EMSY GATAD2B

4.20e-0528976623752268
Pubmed

Activity-Based Probes for HECT E3 Ubiquitin Ligases.

UBR5 HUWE1

4.69e-05576228425671
Pubmed

Analysis of dyslexia candidate genes in the Raine cohort representing the general Australian population.

KIAA0319 MRPL19

4.69e-05576220846247
Pubmed

Fatty Acid Synthase-Suppressor Screening Identifies Sorting Nexin 8 as a Therapeutic Target for NAFLD.

DYNC2I2 SNX8

7.03e-05676234231239
Pubmed

Cleavage of TFIIA by Taspase1 activates TRF2-specified mammalian male germ cell programs.

GTF2A1 KMT2A

7.03e-05676224176642
Pubmed

Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

UBR5 NUP210 USP19 KDM4B

7.04e-0510076410048485
Pubmed

Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

FNBP4 R3HDM2 SIK3 INPP5F

7.61e-0510276410231032
Pubmed

ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease.

NRBP1 TSC22D1 AAK1 WNK1 CAPRIN1

8.32e-0520276533601422
Pubmed

Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.

EP400 RBM27 CIZ1 KMT2A HUWE1 WNK1 KDM4B SPICE1

8.34e-0564576825281560
Pubmed

SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.

TRERF1 DSG1 UBR5 ACIN1 SIK3 CAPRIN1 GATAD2B SPICE1

9.27e-0565576835819319
Pubmed

RFX2 is essential in the ciliated organ of asymmetry and an RFX2 transgene identifies a population of ciliated cells sufficient for fluid flow.

RFX2 RFX3

9.83e-05776222233545
Pubmed

TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation.

UBR5 LIN54 R3HDM2 MGA

9.84e-0510976433554859
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

DOCK4 ARHGAP32 DYNC2I2 UBR5 TUT7 AAK1 SIK3 MGA EMSY

1.01e-0485376928718761
Pubmed

Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes.

EP400 KMT2A ACIN1

1.08e-044276335705031
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

DOCK4 ARHGAP32 WEE1 AAK1 KMT2A SIK3 INPP5F WNK1 SPICE1

1.08e-0486176936931259
Pubmed

Interaction network of human early embryonic transcription factors.

TRERF1 EP400 LIN54 KMT2A MGA EMSY

1.22e-0435176638297188
Pubmed

USP7 Regulates Cytokinesis through FBXO38 and KIF20B.

EP400 UBR5 WEE1 ZBTB40

1.25e-0411676430804394
Pubmed

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.

KPNA5 EP400 RBM26 MGA EMSY

1.29e-0422276537071664
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

UBR5 ZBTB40 SIK3 WNK1 KDM4B

1.38e-0422576512168954
Pubmed

Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.

DYNC2I2 UBR5 AAK1 MGA PAGE5

1.41e-0422676531452512
Pubmed

Genome-scale RNAi screen for host factors required for HIV replication.

NRBP1 GTF2A1 UBR5 AAK1 NKTR WNK1

1.42e-0436176618976975
Pubmed

An improved smaller biotin ligase for BioID proximity labeling.

LIN54 RBM26 CCDC168 EMSY

1.57e-0412376426912792
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

SP2 GTF2A1 TUT7 SREBF2 KMT2A ELF1 QRICH1 KDM4B

1.60e-0470976822988430
Pubmed

A census of human transcription factors: function, expression and evolution.

TRERF1 SP2 TSC22D1 SREBF2 KMT2A ELF1 MGA RFX2 RFX3

1.61e-0490876919274049
Pubmed

Auditory cortex interneuron development requires cadherins operating hair-cell mechanoelectrical transduction.

PCDH15 CDH15

1.68e-04976228705869
Pubmed

The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development.

LIN54 MGA GATAD2B

1.94e-045176322770845
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

KIAA0319 ARHGAP32 EP400 FNBP4

1.94e-0413076412421765
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

POLR3B EP400 TUT7 RBM26 HUWE1 WNK1 MGA GATAD2B

2.00e-0473376834672954
Pubmed

Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.

ARHGAP32 DSG1 CIZ1 MRPL19 HUWE1 MGA CAPRIN1

2.05e-0455176734728620
Pubmed

The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.

TRERF1 EP400 UBR5 RBM27 PCDH15 HUWE1

2.34e-0439676626687479
Pubmed

USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1.

DSG1 USP19

2.56e-041176219015242
Pubmed

The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.

DYNC2I2 EP400 LIN54 ACIN1 HUWE1 MGA GATAD2B

2.89e-0458376729844126
Pubmed

Global phosphoproteome of HT-29 human colon adenocarcinoma cells.

UBR5 AAK1 ACIN1

2.99e-045976316083285
Pubmed

A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.

EP400 MGA EMSY GATAD2B

3.02e-0414676423892456
Pubmed

Identification of E-box factor TFE3 as a functional partner for the E2F3 transcription factor.

WNK1 MGA

3.07e-041276212748276
Pubmed

NRBP1-Containing CRL2/CRL4A Regulates Amyloid β Production by Targeting BRI2 and BRI3 for Degradation.

NRBP1 TSC22D1

3.07e-041276232160551
Pubmed

Functional proteomics mapping of a human signaling pathway.

UBR5 FNBP4 LTBP3 QRICH1 HUWE1 MGA GATAD2B

3.13e-0459176715231748
Pubmed

The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes.

EP400 KMT2A

3.62e-041376216510874
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

POLR3B EP400 UBR5 RBM27 RBM26 KMT2A ACIN1 QRICH1 GATAD2B

3.64e-04101476932416067
Pubmed

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.

KPNA5 ARHGAP32 CLEC4F R3HDM2 QRICH1 WNK1 CCDC33

3.72e-0460876716713569
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

NRBP1 GTF2A1 FRAS1 UBR5 NUP210 FNBP4 CIZ1 MRPL19 SIK3 CAPRIN1 SPICE1

3.75e-041487761133957083
Pubmed

The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.

TRERF1 SP2 PHC3 EP400 UBR5

3.91e-0428276523667531
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

MFAP2 EP400 DSG1 UBR5 NUP210 CIZ1 ACIN1 HUWE1 MGA

3.91e-04102476924711643
Pubmed

PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells.

EP400 MGA EMSY

3.97e-046576322496869
Pubmed

K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains.

UBR5 HUWE1 GATAD2B

3.97e-046576329378950
Pubmed

Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.

WEE1 KMT2A ACIN1 HUWE1

3.98e-0415776430686591
Pubmed

A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening.

SREBF2 ELF1

4.22e-041476210976766
Pubmed

The ubiquitin ligase TRIM25 targets ERG for degradation in prostate cancer.

UBR5 HUWE1

4.22e-041476227626314
Pubmed

Genetic interaction mapping in mammalian cells using CRISPR interference.

PHC3 EP400 KMT2A

4.74e-046976328481362
InteractionNFYC interactions

SP2 EP400 CSN2 LIN54 SREBF2 KMT2A ELF1 MGA EMSY

2.18e-08177769int:NFYC
InteractionFOXJ2 interactions

UBR5 LIN54 QRICH1 RFX2 RFX3 EMSY GATAD2B

2.28e-0881767int:FOXJ2
InteractionFHL2 interactions

SP2 PHC3 EP400 RBM27 CSN2 SREBF2 ELF1 QRICH1 WNK1 RFX3 EMSY GATAD2B

2.80e-083967612int:FHL2
InteractionNUP43 interactions

PHC3 EP400 DSG1 UBR5 LIN54 RBM26 CIZ1 KMT2A ACIN1 ELF1 NKTR CCDC168 MGA EMSY

7.69e-086257614int:NUP43
InteractionFEV interactions

SP2 PHC3 EP400 LIN54 KMT2A ELF1 MGA EMSY

9.68e-07203768int:FEV
InteractionELF2 interactions

EP400 LIN54 ZBTB40 KMT2A ELF1 MGA EMSY

2.03e-06156767int:ELF2
InteractionNFIX interactions

EP400 LIN54 ZBTB40 KMT2A ELF1 QRICH1 MGA EMSY

2.24e-06227768int:NFIX
InteractionSIRT6 interactions

EP400 UBR5 RBM27 WEE1 TUT7 NUP210 FNBP4 NKTR QRICH1 HUWE1 CAPRIN1 GATAD2B

3.79e-066287612int:SIRT6
InteractionSNRNP40 interactions

PHC3 EP400 DSG1 UBR5 CIZ1 KMT2A ACIN1 ELF1 NKTR QRICH1 MGA EMSY

4.38e-066377612int:SNRNP40
InteractionELF1 interactions

EP400 LIN54 KMT2A ELF1 MGA EMSY

8.10e-06126766int:ELF1
InteractionKLF3 interactions

EP400 LIN54 KMT2A ELF1 MGA EMSY GATAD2B

2.44e-05228767int:KLF3
InteractionDYNLT1 interactions

NRBP1 DYNC2I2 LIN54 AAK1 CIZ1 KMT2A EMSY

3.47e-05241767int:DYNLT1
InteractionASF1A interactions

BDP1 EP400 LIN54 KMT2A MGA EMSY GATAD2B

4.28e-05249767int:ASF1A
InteractionNUP50 interactions

KPNA5 GTF2A1 TSC22D1 RBM27 RBM26 FNBP4 IPO13 KMT2A

4.29e-05341768int:NUP50
InteractionASH2L interactions

BDP1 UBR5 KMT2A ELF1 MGA EMSY KDM4B

6.34e-05265767int:ASH2L
InteractionPOU5F1 interactions

EP400 UBR5 RBM27 PCDH15 ACIN1 HUWE1 MGA RFX2 EMSY GATAD2B

6.61e-055847610int:POU5F1
InteractionELF4 interactions

SP2 EP400 LIN54 MGA EMSY

7.42e-05115765int:ELF4
InteractionCSNK2A2 interactions

GTF2A1 PHC3 POLR3B EP400 WEE1 KMT2A NKTR HUWE1 MGA EMSY GATAD2B

7.56e-057187611int:CSNK2A2
InteractionAR interactions

TRERF1 EP400 UBR5 RBM27 LIN54 RBM26 KMT2A ACIN1 HUWE1 DCC MGA EMSY GATAD2B

7.85e-059927613int:AR
InteractionELK3 interactions

SP2 EP400 LIN54 MGA EMSY

9.07e-05120765int:ELK3
InteractionPOLR1G interactions

PHC3 POLR3B EP400 LIN54 CIZ1 KMT2A HUWE1 MGA GATAD2B

9.13e-05489769int:POLR1G
InteractionKIAA0319 interactions

KIAA0319 HUWE1

1.39e-045762int:KIAA0319
InteractionCEBPA interactions

TRERF1 EP400 UBR5 RBM27 LIN54 RBM26 ZBTB40 KMT2A ACIN1 ELF1 QRICH1 CAPRIN1 EMSY GATAD2B

2.04e-0412457614int:CEBPA
InteractionYWHAG interactions

DOCK4 NRBP1 ARHGAP32 WEE1 AAK1 KMT2A ACIN1 R3HDM2 NKTR HUWE1 SIK3 INPP5F WNK1 SPICE1

2.09e-0412487614int:YWHAG
InteractionTERF2IP interactions

PHC3 EP400 RBM27 LIN54 CIZ1 KMT2A MGA EMSY GATAD2B

2.27e-04552769int:TERF2IP
InteractionL3MBTL2 interactions

LIN54 CIZ1 ELF1 MGA GATAD2B CCDC33

2.38e-04231766int:L3MBTL2
InteractionNAA40 interactions

GTF2A1 PHC3 EP400 DSG1 RBM27 RBM26 AAK1 CIZ1 KMT2A ACIN1 WNK1 EMSY

2.80e-049787612int:NAA40
InteractionH2BC8 interactions

PHC3 EP400 LIN54 CIZ1 KMT2A ELF1 MGA GATAD2B KDM4B

3.10e-04576769int:H2BC8
GeneFamilyRegulatory factor X family

RFX2 RFX3

1.99e-0484921153
GeneFamilyGATA zinc finger domain containing|Myb/SANT domain containing

TRERF1 BDP1 EP400

3.98e-0453493532
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

MAG HMCN1 DCC MDGA1

9.40e-04161494593
GeneFamilyCadherin related

DCHS2 PCDH15

9.53e-041749224
GeneFamilyArmadillo repeat containing|Importins

KPNA5 IPO13

1.07e-0318492596
GeneFamilyZinc fingers CCCH-type

RBM27 RBM26

4.04e-033549273
CoexpressionGSE14908_RESTING_VS_HDM_STIM_CD4_TCELL_ATOPIC_PATIENT_DN

SP2 NUP210 PCDH15 QRICH1 EMSY GATAD2B SPICE1

1.90e-06200767M7075
CoexpressionGSE21033_1H_VS_12H_POLYIC_STIM_DC_DN

FNBP4 ELF1 R3HDM2 NKTR HUWE1 WNK1

3.49e-06141766M7720
CoexpressionBUSSLINGER_GASTRIC_IMMUNE_CELLS

TRERF1 BDP1 PHC3 EP400 UBR5 RBM27 NUP210 RBM26 FNBP4 AAK1 KMT2A ELF1 HUWE1 SIK3 WNK1 GATAD2B

4.72e-0614927616M40023
CoexpressionGSE13738_RESTING_VS_BYSTANDER_ACTIVATED_CD4_TCELL_UP

ARHGAP32 TSC22D1 RBM27 TUT7 RBM26 MAML2

2.16e-05194766M3321
CoexpressionGSE11057_NAIVE_CD4_VS_PBMC_CD4_TCELL_UP

FNBP4 ZBTB40 ZNF407 LTBP3 QRICH1 MAML2

2.43e-05198766M3108
CoexpressionGSE26727_WT_VS_KLF2_KO_LPS_STIM_MACROPHAGE_UP

NUP210 CIZ1 ACIN1 HERC2P3 USP19 SPICE1

2.50e-05199766M8301
CoexpressionGSE14413_UNSTIM_VS_IFNB_STIM_NIH3T3_CELLS_UP

TRERF1 SP2 NUP210 CIZ1 GATAD2B

5.70e-05141765M466
CoexpressionAtlasDevelopingGonad_e16.5_ovary_emap-9563_k-means-cluster#1_top-relative-expression-ranked_1000

MORC1 MFAP2 HMCN1 RBM26 FNBP4 ACIN1 MGA

3.68e-06182757gudmap_developingGonad_e16.5_ovary_1000_k1
CoexpressionAtlasDevelopingGonad_e18.5_ovary_emap-12283_k-means-cluster#4_top-relative-expression-ranked_1000

MORC1 MFAP2 HMCN1 RBM26 ACIN1 MGA

2.18e-05160756gudmap_developingGonad_e18.5_ovary_1000_k4
ToppCellfacs-Marrow-KLS-3m-Hematologic-hematopoietic_stem_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP32 TSC22D1 WEE1 LTBP3 MDGA1 CAPRIN1

8.69e-07189766533685a921a65d84107d8d33c43b4fffde019143
ToppCellfacs-Marrow-KLS-3m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP32 TSC22D1 WEE1 LTBP3 MDGA1 CAPRIN1

8.69e-07189766dca56ab02bf0505f9a352ff907edaef30906d854
ToppCellfacs-Marrow-KLS-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP32 TSC22D1 WEE1 LTBP3 MDGA1 CAPRIN1

8.96e-07190766a513c1e7df62c28128c932a68b252ee8f0255172
ToppCellfacs-Marrow-KLS-3m-Hematologic-MPP_Fraction_B_+_C|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP32 TSC22D1 WEE1 LTBP3 MDGA1 CAPRIN1

9.53e-0719276603dcd9405d3d76fc7455066ba5d83c09cd17072d
ToppCellhuman_hepatoblastoma|World / Sample and Cell Type and Tumor Cluster (all cells)

BDP1 FRAS1 UBR5 NKTR WNK1 RFX3

9.82e-07193766e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCellControl-Fibroblasts-Alveolar_FB|Control / group, cell type (main and fine annotations)

DOCK4 FRAS1 HMCN1 PCDH15 DCC

1.71e-0518776592d468dde81125d51daf7abd4703741abe1ab91c
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

KMT2A ZNF407 NKTR HUWE1 SIK3

1.75e-05188765ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DOCK4 FRAS1 HMCN1 PCDH15 DCC

1.80e-05189765203c80030df08ae112f9ae4043709f455d87ce89
ToppCell(5)_Fibroblasts-(5)_Fibroblast-C_(Myofibroblast)|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)

DOCK4 MFAP2 TSC22D1 FRAS1 HMCN1

1.85e-0519076571e112dfb8c3190fe0286b45a046ea789eb6a8db
ToppCellhuman_hepatoblastoma-Tumor_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

BDP1 FRAS1 UBR5 NKTR WNK1

1.94e-05192765916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

AAK1 KMT2A NKTR MAML2 SIK3

1.94e-0519276547646d7e4990be85072987f92bf18d52f8da752e
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

DOCK4 HMCN1 PCDH15 MAML2 DCC

1.99e-051937659f69edc97b868d23998abc98928a2e89a885ef8a
ToppCellsevere-low-quality_cells|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

KPNA5 FRAS1 AAK1 NKTR RFX3

1.99e-051937659337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCelldroplet-Limb_Muscle-MUSCLE|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BDP1 MFAP2 TSC22D1 WEE1 TUT7

2.04e-05194765e3d63874111d1e8da3977329426e4dcf68d6de87
ToppCellsevere-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

FRAS1 AAK1 KMT2A NKTR RFX3

2.20e-0519776557ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCellParenchymal-NucSeq|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations

DOCK4 ARHGAP32 ZNF407 MAML2 SIK3

2.25e-051987651996373bdccc55aac347d349bd22f6aad6d0c668
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

BDP1 PHC3 AAK1 ZNF407 NKTR

2.30e-05199765f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

ARHGAP32 UBR5 ZNF407 MAML2 SIK3

2.30e-0519976594b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma-3|TCGA-Brain / Sample_Type by Project: Shred V9

UBR5 PCDH15 ZBTB40 CCDC168

8.41e-051357643351e8b9e417397c5fa9f856184ff24ce1a27242
Diseaseobsolete_red blood cell distribution width

MAG EP400 RBM27 AVL9 LIN54 TUT7 NUP210 ZBTB40 ZNF407 R3HDM2 SIK3 WNK1 CDH15

2.37e-0513477313EFO_0005192
DiseaseMalignant neoplasm of breast

TRERF1 KPNA5 GTF2A1 SREBF2 MRPL19 SIK3 WNK1 RFX2 FSCB EMSY

3.04e-0410747310C0006142
Diseasechenodeoxycholate measurement

HMCN1 DCC

6.21e-0415732EFO_0010471
Diseaseeosinophilic esophagitis

DSG1 DCC FSCB EMSY

7.26e-04163734EFO_0004232
Diseaseinsomnia measurement

UBR5 PCDH15 KMT2A DCC MDGA1 KDM4B

8.07e-04443736EFO_0007876
DiseaseFEV/FEC ratio

MFAP2 DCHS2 FRAS1 HMCN1 TUT7 R3HDM2 LTBP3 MAML2 DCC MGA

8.61e-0412287310EFO_0004713
DiseaseIGF-1 measurement

PHC3 LIN54 SREBF2 R3HDM2 KDM4B CCDC33

1.33e-03488736EFO_0004627
Diseaseulcerative colitis

NUP210 ZBTB40 MAML2 EMSY CDH15

1.46e-03335735EFO_0000729
Diseasered blood cell density measurement

EP400 UBR5 LIN54 ZBTB40 R3HDM2 MAML2 SIK3 WNK1

1.47e-03880738EFO_0007978
DiseaseAntiglaucoma preparations and miotics use measurement

FNBP4 KMT2A

1.89e-0326732EFO_0009944
Diseaseunipolar depression, depressive symptom measurement

KMT2A DCC

1.89e-0326732EFO_0003761, EFO_0007006

Protein segments in the cluster

PeptideGeneStartEntry
SGQEVATPPVPQLQV

ACIN1

676

Q9UKV3
QPQVVEAQTQLQIPV

EP400

616

Q96L91
GDIVQPVLNPEPNTV

ACOT7L

131

Q6ZUV0
PTSIPEVQQENIINP

BDP1

2251

A6H8Y1
IQAPTQVPVVVSPRN

ELF1

421

P32519
PVVPAQQPRVRQQAL

AMELY

101

Q99218
VNEPLANNPNPIVVI

CCDC33

391

Q8N5R6
ANNPNPIVVIARVVP

CCDC33

396

Q8N5R6
APAQEPAIQAPVRQQ

AAK1

586

Q2M2I8
RLAQPNQVPVQPEAT

CAPRIN1

416

Q14444
NQVPVQPEATQVPLV

CAPRIN1

421

Q14444
NPPIDQVIQKPGVVQ

KPNA5

116

O15131
QVPVGSDSQNVVQPP

R3HDM2

611

Q9Y2K5
QPLVQQPILPVVKQS

RBM26

621

Q5T8P6
VIQTEPPVPVSINSN

RBM27

536

Q9P2N5
PQLTVHQPTEQPIQV

QRICH1

121

Q2TAL8
PTPPTVENQQRLQAE

GUCY2C

1011

P25092
QPQPQFIPVDEITVT

MORC1

566

Q86VD1
PREAQVQLNVQFPPE

MDGA1

526

Q8NFP4
QRINSAPQQIEVFPP

NUP210

1066

Q8TEM1
TQPELQVPGPVENLQ

DCC

521

P43146
QVIQEPQLSLQPEPV

PAQR7

16

Q86WK9
IPIAFQQTNRPVPVV

FRAS1

3641

Q86XX4
PLATAPNVQQIQVPG

LIN54

341

Q6MZP7
DIVNTPNIVVPPEVV

MAG

136

P20916
RPENAAQIPVATPQV

MGA

1736

Q8IWI9
SVQDVEIPPNIPSVQ

FSCB

111

Q5H9T9
QVQTEAPVPVSVQPP

DYNC2I2

86

Q96EX3
HPQEVQRTVPQPVQS

C9orf131

846

Q5VYM1
VVIPAPIQQVVTGQS

KDM4B

66

O94953
PVVQNAASIVQPSPA

GATAD2B

201

Q8WXI9
EQPPVVGQVQAATNI

ARHGAP32

1316

A7KAX9
PNQQVVGTEERIPIP

HUWE1

751

Q7Z6Z7
TLPPPQTVAVNLQVQ

PHC3

561

Q8NDX5
QTVAVNLQVQPPAPV

PHC3

566

Q8NDX5
TVIPQIPPDNANIIE

DSG1

611

Q02413
VSEPPPVIQVPNNVT

HMCN1

516

Q96RW7
PVIQVPNNVTVTPGE

HMCN1

521

Q96RW7
RPQQPQQEEVTSPVV

NRBP1

411

Q9UHY1
PPLQGQAVVNIQVIP

DCHS2

1381

Q6V1P9
QRAVAPPNQLTPAVQ

MAML2

1011

Q8IZL2
NPIIVTPPIQAIDQD

PCDH15

296

Q96QU1
TPPIQAIDQDRNIQP

PCDH15

301

Q96QU1
ENQVNEQSAPLPVPV

DOCK4

1866

Q8N1I0
IQVSQCQPVTPENPQ

CEP126

816

Q9P2H0
TVQPQANTGQVVLIP

AVL9

371

Q8NBF6
QQVVPYPQRAVPVQA

CSN2

181

P05814
QISAEVQAPPPVVNV

LTBP3

216

Q9NS15
LQVPVSPTVPIQNQK

KMT2A

3031

Q03164
VAVLPEVQVTQNPAN

KMT2A

3611

Q03164
QLPTLMAQPPQTVVQ

EMSY

1031

Q7Z589
PQQLQPAEPIQREET

CCDC168

1866

Q8NDH2
PQQAQALGVPITPVN

FAM186A

1641

A6NE01
QKSPPEPEIINQVQQ

INPP5F

1101

Q9Y2H2
QPPQQREQPLNVTVC

CDH15

566

P55291
PQGPNPVVVVLQQVF

IPO13

671

O94829
SQQQVQQEVIPAPTP

MFAP2

66

P55001
QPVGPVIVQQPTEEK

PAGE5

41

Q96GU1
PQAIEPQAIVQQVPA

SNX8

36

Q9Y5X2
QEAVQEVPRVVQNPP

FNBP4

76

Q8N3X1
VVQPVVAENIPVIPL

NKTR

596

P30414
QVPQQVQPVQHVYPA

RFX2

56

P48378
VPTQVVQQVPVQQQV

RFX3

26

P48380
PQVQLINPENQIVEP

SIK3

426

Q9Y2K2
PAQSQQVTIQVQEPV

SIK3

801

Q9Y2K2
TTVIPVAQPQGIQLP

TSC22D1

681

Q15714
VAQPQGIQLPVQPTA

TSC22D1

686

Q15714
AVQQPSTQVPPSVIQ

TSC22D1

741

Q15714
GIQPVPLQTITNENP

HERC2P3

486

Q9BVR0
QGPIVVNQDPITQSI

SPICE1

141

Q8N0Z3
QQQTRPVPKPVQAVI

CLEC4F

61

Q8N1N0
EAEPLKQVQPQVQPQ

CIZ1

396

Q9ULV3
PVVQEPNQKVPVNEL

MRPL19

206

P49406
GVQAPVIQQVLAPLP

GTF2A1

196

P52655
EVQQRPQVPSVPISK

USP19

776

O94966
DVRQTPQVNINPFTP

WEE1

226

P30291
AVVQQVQVVPPKAEQ

SP2

296

Q02086
VQVVPPKAEQQQVVQ

SP2

301

Q02086
VAAPQVQQVPVLVQP

SREBF2

231

Q12772
VQQVPVLVQPQIIKT

SREBF2

236

Q12772
TQIPLEGSNVPQQPQ

POLR3B

836

Q9NW08
PAPPPEQVQQVIIFQ

ZNF407

1856

Q9C0G0
IQGEPQIPVATQPSV

WNK1

801

Q9H4A3
QVPSIPPLVQPVANV

WNK1

1596

Q9H4A3
LQQRNPPVIPVLQEI

TUT7

1181

Q5VYS8
ELIPNGVNIPVTPQN

UBR5

2616

O95071
VIQTPEPVAPTEQVI

ZBTB40

1176

Q9NUA8
LQPAQEVTTVQLQPV

ZNF628

856

Q5EBL2
QEIQTQPQQIRPSQP

TRERF1

286

Q96PN7
AVVTVIVQPENNRPP

KIAA0319

611

Q5VV43