Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	dendritic spine	ANKS1B DDN GRIN2B FARP1 SYNE1	4.22e-05	242	34	5	GO:0043197
GeneOntologyCellularComponent	neuron spine	ANKS1B DDN GRIN2B FARP1 SYNE1	4.65e-05	247	34	5	GO:0044309
Domain	C1-set	CD1C NCR3LG1	4.34e-03	54	34	2	PF07654
Domain	IGc1	CD1C NCR3LG1	4.66e-03	56	34	2	SM00407
Domain	Ig_C1-set	CD1C NCR3LG1	4.99e-03	58	34	2	IPR003597
Domain	RhoGEF	FGD4 FARP1	6.80e-03	68	34	2	SM00325
Domain	DH_2	FGD4 FARP1	7.19e-03	70	34	2	PS50010
Domain	RhoGEF	FGD4 FARP1	7.19e-03	70	34	2	PF00621
Domain	HEAT_REPEAT	ECPAS TANGO6	7.19e-03	70	34	2	PS50077
Domain	DH-domain	FGD4 FARP1	7.39e-03	71	34	2	IPR000219
Domain	-	FGD4 FARP1	7.39e-03	71	34	2	1.20.900.10
Pathway	REACTOME_TRNA_MODIFICATION_IN_THE_MITOCHONDRION	PUS1 PRORP	1.17e-04	9	26	2	M27610
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	ANKS1B DDN GRIN2B FARP1 SYNE1	4.41e-06	251	34	5	27507650
Pubmed	ANKS1B Gene Product AIDA-1 Controls Hippocampal Synaptic Transmission by Regulating GluN2B Subunit Localization.	ANKS1B GRIN2B	5.56e-06	4	34	2	26085624
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	ANKS1B DDN GRIN2B FARP1 SYNE1 KDM1A ETF1	3.42e-05	963	34	7	28671696
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	PUS1 TMEM192 TXNDC16 PRORP ECPAS PRPF8 KDM1A	3.67e-05	974	34	7	28675297
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	ECPAS PRPF8 GTF3C4 KDM1A	6.23e-05	220	34	4	35785414
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	BPIFB1 ECPAS PRPF8 SYNE1 KDM1A TANGO6	8.15e-05	754	34	6	35906200
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TXNDC16 PRORP MON1B WNK1 TANGO6	1.11e-04	493	34	5	15368895
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	ECPAS PRPF8 GTF3C4 KDM1A ETF1	1.15e-04	497	34	5	36774506
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	MYOCD ECPAS PRPF8 SYNE1 GTF3C4 ETF1	1.18e-04	807	34	6	30575818
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	PRORP ECPAS WNK1	1.45e-04	104	34	3	9205841
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	ANKS1B DDN GRIN2B SYNE1	1.60e-04	281	34	4	28706196
Pubmed	Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress.	PUS1 ECPAS RIOK2 ETF1	2.72e-04	323	34	4	24797263
Pubmed	A protein interaction landscape of breast cancer.	BPIFB1 ECPAS GTF3C4 ETF1 RPAP2	3.56e-04	634	34	5	34591612
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	ANKS1B PPP2R2C GRIN2B FGD4 FARP1 SYNE1 ETF1	3.98e-04	1431	34	7	37142655
Pubmed	Charting the landscape of tandem BRCT domain-mediated protein interactions.	PUS1 GTF3C4 KDM1A ETF1 RPAP2	4.58e-04	670	34	5	22990118
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	PPP2R2C PRORP AADAT ECPAS CFAP69 FARP1 RPAP2	5.06e-04	1489	34	7	28611215
Pubmed	Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.	ECPAS PRPF8 KDM1A RPAP2	5.53e-04	390	34	4	17643375
Pubmed	A molecular profile of a hematopoietic stem cell niche.	MON1B FGD4	7.07e-04	40	34	2	12226475
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	ECPAS GTF3C4 KDM1A TANGO6	7.17e-04	418	34	4	34709266
Pubmed	A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells.	PRORP PRPF8 ETF1 TANGO6	7.23e-04	419	34	4	28700943
Pubmed	Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates.	WNK1 KDM1A	7.43e-04	41	34	2	15561718
Pubmed	Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.	GRIN2B FARP1	8.17e-04	43	34	2	21116278
GeneFamily	C1-set domain containing	CD1C NCR3LG1	7.01e-04	42	17	2	591
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	FGD4 FARP1	1.72e-03	66	17	2	722
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	WNK1 FARP1	1.23e-02	181	17	2	694
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	FGD4 FARP1	1.57e-02	206	17	2	682
GeneFamily	WD repeat domain containing	PPP2R2C WDR49	2.47e-02	262	17	2	362
Disease	amino acid measurement	TXNDC16 UNC13C GRIN2B AADAT FARP1 SYNE1	9.39e-05	678	33	6	EFO_0005134
Disease	schizophrenia (biomarker_via_orthology)	GRIN2B KDM1A	1.26e-04	15	33	2	DOID:5419 (biomarker_via_orthology)
Disease	visuospatial function measurement	GRIN2B FARP1	3.88e-04	26	33	2	EFO_0803533
Disease	bipolar disorder (is_implicated_in)	GRIN2B SYNE1	4.83e-04	29	33	2	DOID:3312 (is_implicated_in)
Disease	bipolar I disorder	ANKS1B WDR49 SYNE1	5.25e-04	141	33	3	EFO_0009963
Disease	health literacy measurement	PPP2R2C FGD4	1.61e-03	53	33	2	EFO_0010104
Disease	smooth surface dental caries	TXNDC16 FARP1	2.20e-03	62	33	2	EFO_0006339
Disease	nucleotide measurement	ANKS1B UNC13C	3.03e-03	73	33	2	EFO_0010513
Disease	thyroxine measurement	TRIM71 AADAT	3.90e-03	83	33	2	EFO_0005130
Disease	age at menarche	DDN UNC13C ECPAS HELQ	4.19e-03	594	33	4	EFO_0004703
Disease	beta-amyloid 1-42 measurement	GRIN2B ETF1	4.28e-03	87	33	2	EFO_0004670
Disease	Uterine leiomyoma	MYOCD SYNE1	4.67e-03	91	33	2	HP_0000131

Protein segments in the cluster

Peptide	Gene	Start	Entry
LEIEEKINKIKWLPQ	PPP2R2C	86	Q9Y2T4
LWIKVKGINDVKELI	AADAT	356	Q8N5Z0
LVNTVLKHIIWLKVI	BPIFB1	76	Q8TDL5
EKRQKWSIVVKILIA	C17orf78	176	Q8N4C9
LWVQKSKLLVIEVKT	DDN	26	O94850
AILVVTKLLRWVKKE	MON1B	501	Q7L1V2
LKKIWEVELINVLKI	ANKS1B	916	Q7Z6G8
ELLWKVEKIRQVKAK	TRIM71	381	Q2Q1W2
VLLIVLIPWKKICNK	NCR3LG1	276	Q68D85
IELLLKKLEESKQWE	ECPAS	1791	Q5VYK3
ELKQKWLKVILLAVT	FGD4	726	Q96M96
LVEKQKVINELTWKL	MYOCD	521	Q8IZQ8
WKKIVKTQEELKELL	KDM1A	431	O60341
VPLVILIVLVLWFKK	CD1C	311	P29017
ITVWLDLLKPIVKQI	FARP1	91	Q9Y4F1
QKVLLKEKSLWEITV	HELQ	786	Q8TDG4
LLENQLVEKLWVLKV	CFAP69	206	A5D8W1
PVKVIEKKLAIWEQL	DHRS9	216	Q9BPW9
LELILKWIEKAKVLA	SYNE1	5536	Q8NF91
VSLKVWLIDDILEKI	PUS1	156	Q9Y606
WREALLLLEDIKKVI	PRORP	226	O15091
WIKVEVQLKDLILAD	PRPF8	1976	Q6P2Q9
KVQTVIILGKVILWI	TMEM192	91	Q8IY95
IIEENLVLWLKKLEA	TXNDC16	711	Q9P2K2
ICEKTVLKRVLKELW	UNC13C	1906	Q8NB66
VLKRVLKELWKLVLN	UNC13C	1911	Q8NB66
LKELWKLVLNKIEKQ	UNC13C	1916	Q8NB66
LLKVLKETLIEWKTE	RPAP2	366	Q8IXW5
QILILKKKILVTGWE	WDR49	241	Q8IV35
QEILLWILGKLERKK	TANGO6	501	Q9C0B7
KSVVFIVLLILQWKK	STIMATE	166	Q86TL2
QVDLIDLVRWKILKD	GTF3C4	536	Q9UKN8
KVLRELVKHKLIAWE	RIOK2	51	Q9BVS4
EKIAIKLWLRIEDIK	WNK1	496	Q9H4A3
NVEIWKIKKLIKSLE	ETF1	11	P62495
KLVIILLNKERKWER	GRIN2B	361	Q13224